ES2001855A6 - Un procedimiento para la preparacion de un compuesto de oxindol farmaceuticamente activo - Google Patents

Un procedimiento para la preparacion de un compuesto de oxindol farmaceuticamente activo

Info

Publication number
ES2001855A6
ES2001855A6 ES8600191A ES8600191A ES2001855A6 ES 2001855 A6 ES2001855 A6 ES 2001855A6 ES 8600191 A ES8600191 A ES 8600191A ES 8600191 A ES8600191 A ES 8600191A ES 2001855 A6 ES2001855 A6 ES 2001855A6
Authority
ES
Spain
Prior art keywords
antiinflammatory
analgesic agents
carboxamines
substituted oxindole
substituted
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES8600191A
Other languages
English (en)
Inventor
Saul Bernard Kadin
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Pfizer Inc
Original Assignee
Pfizer Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from US06/825,017 external-priority patent/US4678802A/en
Application filed by Pfizer Inc filed Critical Pfizer Inc
Publication of ES2001855A6 publication Critical patent/ES2001855A6/es
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04—Indoles; Hydrogenated indoles
    • C07D209/30—Indoles; Hydrogenated indoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to carbon atoms of the hetero ring
    • C07D209/42—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
    • C07D409/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pain & Pain Management (AREA)
  • Public Health (AREA)
  • Rheumatology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Indole Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)

Abstract

UN PROCEDIMIENTO PARA LA PREPARACION DE UN COMPUESTO DE OXINDOL FARMACEUTICAMENTE ACTIVO DE FORMULA (I), DONDE X ES H, F, CL, BR, ALQUILO C1-4, ALQUILTIO C1-4, ALCOXI C1-4, CICLOALQUILO C3-6, NITRO, TRIFLUORMETILO, ACILO C2-4, BENZOILO O TENOILO; Y ES H, F, CL, BR, ALQUILO, ALCOXI O ALQUILTIO C1-4; SI X E Y SE CONSIDERAN CONJUNTAMENTE SON 4,5-, 5,6-, O 6,7-METILENDIOXI; A ES NHR2, R3 O NHCOR3; R1 Y R2 SON CADA UNO H, ALQUILO C1-6, CICLOALQUILO C3-7, HETEROCICLO OPCIONALMENTE METILADO, O UN GRUPO FENILO OPCIONALMENTE SUSTITUIDO; Y R3 ES ALQUILO C1-4 O FENILO. EL PROCEDIMIENTO COMPRENDE LA REACCION DE UN OXINDOL (II) CON UN ISOCIANATO R1NCO, OPCIONALMENTE EN PRESENCIA DE UN DISOLVENTE APROTICO POLAR Y DE UNA BASE. LOS COMPUESTOS (I) OBTENIDOS SON UTILES COMO AGENTES ANTI-INFLAMATORIOS Y ANALGESICOS EN MAMIFEROS.
ES8600191A 1985-07-09 1986-07-08 Un procedimiento para la preparacion de un compuesto de oxindol farmaceuticamente activo Expired ES2001855A6 (es)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US75320085A 1985-07-09 1985-07-09
US82129686A 1986-01-22 1986-01-22
US06/825,017 US4678802A (en) 1985-07-09 1986-01-31 1-acylcarbamoyloxindole-3-carboxamides as antiinflammatory agents

Publications (1)

Publication Number Publication Date
ES2001855A6 true ES2001855A6 (es) 1988-07-01

Family

ID=27419443

Family Applications (2)

Application Number Title Priority Date Filing Date
ES8600191A Expired ES2001855A6 (es) 1985-07-09 1986-07-08 Un procedimiento para la preparacion de un compuesto de oxindol farmaceuticamente activo
ES8703589A Expired ES2009227A6 (es) 1985-07-09 1987-12-15 Un procedimiento para la preparacion de un compuesto de oxindol farmaceuticamente activo.

Family Applications After (1)

Application Number Title Priority Date Filing Date
ES8703589A Expired ES2009227A6 (es) 1985-07-09 1987-12-15 Un procedimiento para la preparacion de un compuesto de oxindol farmaceuticamente activo.

Country Status (19)

Country Link
EP (1) EP0208510B1 (es)
JP (1) JPH0610193B2 (es)
CN (1) CN86105309A (es)
AT (1) ATE67185T1 (es)
AU (1) AU566065B2 (es)
CA (1) CA1286663C (es)
DE (1) DE3681358D1 (es)
DK (1) DK324286A (es)
ES (2) ES2001855A6 (es)
FI (1) FI862882A (es)
GR (1) GR861760B (es)
HU (2) HUT41386A (es)
IE (1) IE58566B1 (es)
IL (1) IL79356A (es)
NO (1) NO862750L (es)
NZ (1) NZ216788A (es)
PH (1) PH22641A (es)
PT (1) PT82931B (es)
YU (2) YU45346B (es)

Families Citing this family (28)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IE68593B1 (en) 1989-12-06 1996-06-26 Sanofi Sa Heterocyclic substituted acylaminothiazoles their preparation and pharmaceutical compositions containing them
FR2655344B1 (fr) * 1989-12-06 1992-04-03 Sanofi Sa Derives heterocycliques d'acylaminothiazoles, leur preparation et compositions pharmaceutiques en contenant.
WO1991009598A1 (en) * 1990-01-05 1991-07-11 Pfizer Inc. Azaoxindole derivatives
FR2677356B1 (fr) * 1991-06-05 1995-03-17 Sanofi Sa Derives heterocycliques d'acylamino-2 thiazoles-5 substitues, leur preparation et compositions pharmaceutiques en contenant.
JPH08288983A (ja) * 1995-04-17 1996-11-01 Tokyo Tsuuki:Kk リンガ回路
US6329416B1 (en) 1999-05-04 2001-12-11 American Home Products Corporation Combination regimens using 3,3-substituted indoline derivatives
US6444668B1 (en) 1999-05-04 2002-09-03 Wyeth Combination regimens using progesterone receptor modulators
US6369056B1 (en) 1999-05-04 2002-04-09 American Home Products Corporation Cyclic urea and cyclic amide derivatives
US6417214B1 (en) 1999-05-04 2002-07-09 Wyeth 3,3-substituted indoline derivatives
US6380178B1 (en) 1999-05-04 2002-04-30 American Home Products Corporation Cyclic regimens using cyclocarbamate and cyclic amide derivatives
US6358947B1 (en) 1999-05-04 2002-03-19 American Home Products Corporation Tetracyclic progesterone receptor modulator compounds and methods
US6399593B1 (en) 1999-05-04 2002-06-04 Wyeth Cyclic regimens using cyclic urea and cyclic amide derivatives
US6355648B1 (en) 1999-05-04 2002-03-12 American Home Products Corporation Thio-oxindole derivatives
US6407101B1 (en) 1999-05-04 2002-06-18 American Home Products Corporation Cyanopyrroles
US6339098B1 (en) 1999-05-04 2002-01-15 American Home Products Corporation 2,1-benzisothiazoline 2,2-dioxides
US6391907B1 (en) 1999-05-04 2002-05-21 American Home Products Corporation Indoline derivatives
US6423699B1 (en) 1999-05-04 2002-07-23 American Home Products Corporation Combination therapies using benzimidazolones
US6380235B1 (en) 1999-05-04 2002-04-30 American Home Products Corporation Benzimidazolones and analogues
US6358948B1 (en) 1999-05-04 2002-03-19 American Home Products Corporation Quinazolinone and benzoxazine derivatives as progesterone receptor modulators
US6306851B1 (en) 1999-05-04 2001-10-23 American Home Products Corporation Cyclocarbamate and cyclic amide derivatives
US6462032B1 (en) 1999-05-04 2002-10-08 Wyeth Cyclic regimens utilizing indoline derivatives
US6498154B1 (en) 1999-05-04 2002-12-24 Wyeth Cyclic regimens using quinazolinone and benzoxazine derivatives
US6509334B1 (en) 1999-05-04 2003-01-21 American Home Products Corporation Cyclocarbamate derivatives as progesterone receptor modulators
US6319912B1 (en) 1999-05-04 2001-11-20 American Home Products Corporation Cyclic regimens using 2,1-benzisothiazoline 2,2-dioxides
UA73119C2 (en) 2000-04-19 2005-06-15 American Home Products Corpoir Derivatives of cyclic thiocarbamates, pharmaceutical composition including noted derivatives of cyclic thiocarbamates and active ingredients of medicines as modulators of progesterone receptors
US6900335B2 (en) 2000-07-19 2005-05-31 Ube Industries, Ltd. Process for producing 5-fluorooxindole and for producing intermediates therefor
EP1370527A1 (en) 2001-03-06 2003-12-17 AstraZeneca AB Indolone derivatives having vascular-damaging activity
JP4770826B2 (ja) * 2007-11-22 2011-09-14 大日本印刷株式会社 ２−オキシインドール誘導体の製造法

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3749731A (en) 1971-07-08 1973-07-31 Warner Lambert Co 2-oxo-n-(2-thiazolyl)-3-indoline-carboxamide
US3882236A (en) 1973-12-26 1975-05-06 Lilly Co Eli Pharmaceutical compositions containing substituted 2-oxo-indolines and the use thereof to treat anxiety and tension
US4556672A (en) * 1984-03-19 1985-12-03 Pfizer Inc. 3-Substituted 2-oxindole-1-carboxamides as analgesic and anti-inflammatory agents
US4690943A (en) * 1984-09-19 1987-09-01 Pfizer Inc. Analgesic and antiinflammatory 1,3-diacyl-2-oxindole compounds

Also Published As

Publication number Publication date
AU5984786A (en) 1987-04-09
ATE67185T1 (de) 1991-09-15
IE861833L (en) 1987-01-09
EP0208510B1 (en) 1991-09-11
PT82931B (pt) 1989-01-30
ES2009227A6 (es) 1989-09-16
IL79356A0 (en) 1986-10-31
JPS6226269A (ja) 1987-02-04
YU114487A (en) 1988-02-29
DE3681358D1 (de) 1991-10-17
NO862750D0 (no) 1986-07-08
YU45346B (en) 1992-05-28
CA1286663C (en) 1991-07-23
FI862882A0 (fi) 1986-07-08
NZ216788A (en) 1988-10-28
DK324286D0 (da) 1986-07-08
EP0208510A2 (en) 1987-01-14
PT82931A (en) 1986-08-01
HUT41386A (en) 1987-04-28
IE58566B1 (en) 1993-10-06
GR861760B (en) 1986-11-10
HU198015A (en) 1989-07-28
NO862750L (no) 1987-01-12
EP0208510A3 (en) 1988-03-02
JPH0610193B2 (ja) 1994-02-09
FI862882A (fi) 1987-01-10
CN86105309A (zh) 1987-01-14
IL79356A (en) 1990-03-19
AU566065B2 (en) 1987-10-08
YU120386A (en) 1988-02-29
PH22641A (en) 1988-10-28
DK324286A (da) 1987-01-10

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