ES2001075A6 - Un procedimiento para la preparacion de nuevos compuestos di-t-butilfenolicos. - Google Patents

Un procedimiento para la preparacion de nuevos compuestos di-t-butilfenolicos.

Info

Publication number
ES2001075A6
ES2001075A6 ES8600951A ES8600951A ES2001075A6 ES 2001075 A6 ES2001075 A6 ES 2001075A6 ES 8600951 A ES8600951 A ES 8600951A ES 8600951 A ES8600951 A ES 8600951A ES 2001075 A6 ES2001075 A6 ES 2001075A6
Authority
ES
Spain
Prior art keywords
butylphenol compounds
butylphenols
arthritis
mammals
stroke
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES8600951A
Other languages
English (en)
Inventor
Jill Ann Panetta
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Eli Lilly and Co
Original Assignee
Eli Lilly and Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Eli Lilly and Co filed Critical Eli Lilly and Co
Publication of ES2001075A6 publication Critical patent/ES2001075A6/es
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
    • C07D277/02—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings
    • C07D277/20—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
    • C07D277/02—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings
    • C07D277/08—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
    • C07D277/12—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D277/14—Oxygen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
    • C07D277/02—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings
    • C07D277/08—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
    • C07D277/12—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D277/16—Sulfur atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
    • C07D277/02—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings
    • C07D277/20—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D277/32—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D277/34—Oxygen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
    • C07D277/02—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings
    • C07D277/20—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D277/32—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D277/36—Sulfur atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D327/00—Heterocyclic compounds containing rings having oxygen and sulfur atoms as the only ring hetero atoms
    • C07D327/02—Heterocyclic compounds containing rings having oxygen and sulfur atoms as the only ring hetero atoms one oxygen atom and one sulfur atom
    • C07D327/04—Five-membered rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Rheumatology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Public Health (AREA)
  • Pain & Pain Management (AREA)
  • Immunology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Thiazole And Isothizaole Compounds (AREA)
  • Heterocyclic Compounds Containing Sulfur Atoms (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

Abstract

SE DESCRIBE UN PROCEDIMIENTO PARA LA PREPARACION DE NUEVOS COMPUESTOS DI-T-BUTILFENOLICOS, DE FORMULA I: CUYAS DEFINICIONES SE MENCIONAN EN LA DESCRIPCION POR REACCION DE UN COMPUESTO DE FORMULA CON UN COMPUESTO DE FORMULA: LOS COMPUESTOS EN LOS QUE Q ES O PUEDEN SER PREPARADOS POR LA REACCION DE UN COMPUESTO DE FORMULA CON ACIDO FORMICO O CON DISULFURO DE CARBONO. LOS COMPUESTOS DE FORMULA I ASI OBTENIDOS, SON UTILES PARA EL TRATAMIENTO DE LA INFLAMACION Y LA ARTRITIS EN MAMIFEROS.
ES8600951A 1985-08-09 1986-08-08 Un procedimiento para la preparacion de nuevos compuestos di-t-butilfenolicos. Expired ES2001075A6 (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US76416085A 1985-08-09 1985-08-09
US86948886A 1986-06-02 1986-06-02

Publications (1)

Publication Number Publication Date
ES2001075A6 true ES2001075A6 (es) 1988-04-16

Family

ID=27117408

Family Applications (1)

Application Number Title Priority Date Filing Date
ES8600951A Expired ES2001075A6 (es) 1985-08-09 1986-08-08 Un procedimiento para la preparacion de nuevos compuestos di-t-butilfenolicos.

Country Status (24)

Country Link
EP (1) EP0211670B1 (es)
JP (1) JPH0625182B2 (es)
KR (1) KR870000889B1 (es)
CN (1) CN1014891B (es)
AR (1) AR243173A1 (es)
AU (1) AU590312B2 (es)
CA (1) CA1285572C (es)
CY (1) CY1619A (es)
DE (1) DE3670951D1 (es)
DK (1) DK169324B1 (es)
ES (1) ES2001075A6 (es)
GR (1) GR862081B (es)
HK (1) HK94791A (es)
HU (1) HU196192B (es)
IE (1) IE58718B1 (es)
IL (1) IL79648A (es)
LV (1) LV10866B (es)
MX (1) MX9203108A (es)
MY (1) MY102365A (es)
NZ (1) NZ217126A (es)
PH (1) PH24517A (es)
PT (1) PT83152B (es)
SG (1) SG80391G (es)
SU (1) SU1516012A3 (es)

Families Citing this family (29)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB8512163D0 (en) * 1985-05-14 1985-06-19 Fujisawa Pharmaceutical Co Oxothiazolidine compound
US5691367A (en) * 1985-08-09 1997-11-25 Eli Lilly And Company Aryl-substituted rhodanine derivatives
US5356917A (en) * 1985-08-09 1994-10-18 Eli Lilly And Company Aryl-substituted rhodanine derivatives
US4897406A (en) * 1987-11-13 1990-01-30 Nisshin Flour Milling Co., Ltd. Rhodanine derivatives and pharmaceutical compositions
US5208250A (en) * 1988-05-25 1993-05-04 Warner-Lambert Company Known and selected novel arylmethylenyl derivatives of thiazolidinones, imidazolidinones and oxazolidinones useful as antiallergy agents and anti-inflammatory agents
IE940525L (en) * 1988-05-25 1989-11-25 Warner Lambert Co Known and selected novel arylmethylenyl derivatives of¹thiazolidinones, imidazolidinones and oxazolidinones useful¹as antiallergy agents and antiinflammatory agents
US5306822A (en) * 1988-05-25 1994-04-26 Warner-Lambert Company Arylmethylenyl derivatives of oxazolidinone
FI93954C (fi) * 1988-11-29 1995-06-26 Warner Lambert Co Menetelmä lääkeaineina käyttökelpoisten 3,5-di-tert-butyyli-4-hydroksifenyylisubstituoitujen 1,2,4- ja 1,3,4-tiadiatsolien sekä oksadiatsolien ja triatsolien valmistamiseksi
ZA902520B (en) * 1989-04-07 1991-12-24 Lilly Co Eli Aryl-substituted rhodanine derivatives
IL96654A (en) * 1989-12-21 1995-06-29 Lilly Co Eli Sutral derivatives containing hydroxybenzyl and sulfur-converted, and pharmaceutical preparations containing them
US5216002A (en) * 1989-12-21 1993-06-01 Eli Lilly And Company Method of treating inflammatory bowel disease
US5143928A (en) * 1990-03-27 1992-09-01 Warner-Lambert Company 3,5-di-tertiarybutyl-4-hydroxyphenylmethylene derivatives of 2-substituted thiazolidinones, oxazolidinones, and imidazolidinones as antiinflammatory agents
DE69123738T2 (de) * 1990-04-27 1997-07-03 Orion-Yhtymae Oy, Espoo Pharmakologisch aktive catecholderivate
ATE157355T1 (de) * 1991-01-21 1997-09-15 Shionogi & Co 3-benzyliden-1-carbamoyl-2-pyrrolidon-analoga
US5158966A (en) * 1991-02-22 1992-10-27 The University Of Colorado Foundation, Inc. Method of treating type i diabetes
US5143929A (en) * 1991-05-09 1992-09-01 Warner-Lambert Company 2-substituted thiazolidinone, oxazolidinone, and imidazolidinone derivatives of fenamates as antiinflammatory agents
NZ248573A (en) * 1992-09-10 1996-02-27 Lilly Co Eli 5-arylmethyl (and methylidene) thiazolidin-4-one derivatives; their preparation and pharmaceutical compositions
DK0595546T3 (da) * 1992-10-28 1996-04-15 Shionogi & Co Benzylidenderivater
ES2152319T3 (es) * 1993-06-23 2001-02-01 Chugai Pharmaceutical Co Ltd Derivado del benceno util contra isquemias.
US6251928B1 (en) * 1994-03-16 2001-06-26 Eli Lilly And Company Treatment of alzheimer's disease employing inhibitors of cathepsin D
US5476865A (en) * 1994-07-06 1995-12-19 Eli Lilly And Company Methods of inhibiting bone loss
JPH10512883A (ja) * 1995-01-23 1998-12-08 イーライ・リリー・アンド・カンパニー 多発性硬化症の治療方法
SI0761657T1 (en) * 1995-09-07 2000-10-31 Eli Lilly And Company Process for preparing benzyl-substituted rhodanine derivatives
PT914122E (pt) * 1996-07-11 2003-12-31 Warner Lambert Co Metodo para o tratamento e prevencao de disturbios neurodegenerativos atraves da administracao de uma tiazolidinona
US6005142A (en) 1996-09-03 1999-12-21 Eli Lilly And Company Process for preparing benzyl-substituted rhodanine derivatives
US6063799A (en) * 1996-09-03 2000-05-16 Eli Lilly And Company Alternate crystal form of Tazofelone
WO2000018748A1 (en) * 1998-09-30 2000-04-06 Roche Diagnostics Gmbh Rhodanine derivatives for the treatment and prevention of metabolic bone disorders
AU2002953533A0 (en) * 2002-12-24 2003-01-16 Arthron Limited Fc receptor modulating compounds and compositions
DE202006018406U1 (de) 2006-12-05 2008-04-10 Seda S.P.A. Verpackung

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE1038050B (de) * 1955-11-17 1958-09-04 Farmaceutici Italia S A Soc Verfahren zur Herstellung von 5-(3', 4'-Dioxybenzyliden)-Derivaten heterocyclischer Verbindungen
JPS5697277A (en) * 1980-01-07 1981-08-05 Takeda Chem Ind Ltd Thiazolidine derivative
JPS5740478A (en) * 1980-08-22 1982-03-06 Ono Pharmaceut Co Ltd Rhodanine derivative, its preparation and aldose reductase inhibitor containing rhodanine derivative
JPS5879944A (ja) * 1981-11-09 1983-05-13 Kanegafuchi Chem Ind Co Ltd ３，５−ジ・タ−シヤリ−・ブチルスチレン誘導体及び抗炎症、鎮痛、解熱剤並びに血小板凝集阻害剤
JPS57130950A (en) * 1981-02-05 1982-08-13 Kanegafuchi Chem Ind Co Ltd 3,5-di-tert-butyl-4-hydroxystyrene derivative and anti- inflammatory, analgesic, antipyretic agent and inhibitor for blood platelet aggregation
US4636516A (en) * 1981-02-19 1987-01-13 Yamanouchi Pharmaceutical Co., Ltd. 3,5-di-tert-butyl-4-hydroxyphenyl-substituted heterocyclic compounds

Also Published As

Publication number Publication date
NZ217126A (en) 1989-01-27
PH24517A (en) 1990-07-18
CN1014891B (zh) 1991-11-27
PT83152A (en) 1986-09-01
LV10866B (en) 1996-04-20
AU590312B2 (en) 1989-11-02
DE3670951D1 (de) 1990-06-13
HK94791A (en) 1991-11-29
MX9203108A (es) 1992-07-01
CA1285572C (en) 1991-07-02
CN86105036A (zh) 1987-02-04
PT83152B (pt) 1989-03-30
DK376986D0 (da) 1986-08-07
HU196192B (en) 1988-10-28
IL79648A0 (en) 1986-11-30
EP0211670B1 (en) 1990-05-09
SU1516012A3 (ru) 1989-10-15
AR243173A1 (es) 1993-07-30
JPH0625182B2 (ja) 1994-04-06
HUT42765A (en) 1987-08-28
LV10866A (lv) 1995-10-20
IL79648A (en) 1991-12-12
CY1619A (en) 1992-07-10
KR870002109A (ko) 1987-03-30
KR870000889B1 (ko) 1987-05-02
EP0211670A2 (en) 1987-02-25
JPS6242977A (ja) 1987-02-24
DK376986A (da) 1987-02-10
DK169324B1 (da) 1994-10-10
EP0211670A3 (en) 1987-05-06
MY102365A (en) 1992-06-17
AU6097286A (en) 1987-02-12
IE58718B1 (en) 1993-11-03
GR862081B (en) 1986-12-24
SG80391G (en) 1991-11-15

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Legal Events

Date Code Title Description
FD1A Patent lapsed

Effective date: 20040809