EP4512470A3 - Methods of treating heart failure with cardiac sarcomere activators - Google Patents

Methods of treating heart failure with cardiac sarcomere activators Download PDF

Info

Publication number
EP4512470A3
EP4512470A3 EP24209435.7A EP24209435A EP4512470A3 EP 4512470 A3 EP4512470 A3 EP 4512470A3 EP 24209435 A EP24209435 A EP 24209435A EP 4512470 A3 EP4512470 A3 EP 4512470A3
Authority
EP
European Patent Office
Prior art keywords
methods
heart failure
activators
treating heart
cardiac sarcomere
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
EP24209435.7A
Other languages
German (de)
English (en)
French (fr)
Other versions
EP4512470A2 (en
Inventor
Narimon HONARPOUR
Fady MALIK
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Amgen Inc
Cytokinetics Inc
Original Assignee
Amgen Inc
Cytokinetics Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Amgen Inc, Cytokinetics Inc filed Critical Amgen Inc
Publication of EP4512470A2 publication Critical patent/EP4512470A2/en
Publication of EP4512470A3 publication Critical patent/EP4512470A3/en
Pending legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/496—Non-condensed piperazines containing further heterocyclic rings, e.g. rifampin, thiothixene or sparfloxacin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0053—Mouth and digestive tract, i.e. intraoral and peroral administration
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure

Landscapes

  • Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Cardiology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Epidemiology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Hospice & Palliative Care (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Nutrition Science (AREA)
  • Physiology (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
EP24209435.7A 2017-06-30 2018-06-29 Methods of treating heart failure with cardiac sarcomere activators Pending EP4512470A3 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201762527983P 2017-06-30 2017-06-30
PCT/US2018/040181 WO2019006235A1 (en) 2017-06-30 2018-06-29 METHODS OF TREATING CARDIAC INSUFFICIENCY WITH CARDIAC SARCOMER ACTIVATORS
EP18745732.0A EP3645002B1 (en) 2017-06-30 2018-06-29 Methods of treating heart failure with cardiac sarcomere activators

Related Parent Applications (1)

Application Number Title Priority Date Filing Date
EP18745732.0A Division EP3645002B1 (en) 2017-06-30 2018-06-29 Methods of treating heart failure with cardiac sarcomere activators

Publications (2)

Publication Number Publication Date
EP4512470A2 EP4512470A2 (en) 2025-02-26
EP4512470A3 true EP4512470A3 (en) 2025-04-23

Family

ID=63013097

Family Applications (2)

Application Number Title Priority Date Filing Date
EP24209435.7A Pending EP4512470A3 (en) 2017-06-30 2018-06-29 Methods of treating heart failure with cardiac sarcomere activators
EP18745732.0A Active EP3645002B1 (en) 2017-06-30 2018-06-29 Methods of treating heart failure with cardiac sarcomere activators

Family Applications After (1)

Application Number Title Priority Date Filing Date
EP18745732.0A Active EP3645002B1 (en) 2017-06-30 2018-06-29 Methods of treating heart failure with cardiac sarcomere activators

Country Status (22)

Country Link
US (4) US11576910B2 (pl)
EP (2) EP4512470A3 (pl)
JP (3) JP2020526483A (pl)
CN (1) CN110996953A (pl)
AU (2) AU2018290983B2 (pl)
BR (1) BR112019028046A2 (pl)
CA (1) CA3068588A1 (pl)
DK (1) DK3645002T3 (pl)
ES (1) ES3008457T3 (pl)
FI (1) FI3645002T3 (pl)
HR (1) HRP20241729T1 (pl)
HU (1) HUE069805T2 (pl)
LT (1) LT3645002T (pl)
MA (1) MA49508B1 (pl)
MD (1) MD3645002T2 (pl)
MX (2) MX2020000190A (pl)
PL (1) PL3645002T3 (pl)
PT (1) PT3645002T (pl)
RS (1) RS66581B1 (pl)
SI (1) SI3645002T1 (pl)
SM (1) SMT202500067T1 (pl)
WO (1) WO2019006235A1 (pl)

Families Citing this family (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EA031185B1 (ru) 2013-03-14 2018-11-30 Эмджен Инк. Гетероциклические соединения и способы их применения
PL3645002T3 (pl) * 2017-06-30 2025-03-24 Amgen Inc. Sposoby leczenia niewydolności serca za pomocą aktywatorów sarkomerów serca
SI3645518T1 (sl) 2017-06-30 2021-11-30 Amgen Inc. Sinteza omekamtiv mekarbila
PL3594199T3 (pl) 2018-07-09 2020-11-16 F.I.S.- Fabbrica Italiana Sintetici S.P.A. Krystaliczny 2-fluoro-3-nitrotoluen i sposób jego wytwarzania
US11465969B2 (en) 2018-08-17 2022-10-11 Cytokinetics, Inc. Salts and crystal forms of omecamtiv mecarbil
WO2020236736A1 (en) * 2019-05-19 2020-11-26 MyoKardia, Inc. Treatment of systolic dysfunction and heart failure with reduced ejection fraction with the compound(r)-4-(1-((3-(difluoromethyl)-1-methyl-1h-pyrazol-4-yl)sulfonyl)-1-fluoroethyl)-n-(isoxazol-3-yl)piperidine-1-carboxamide
US20230090391A1 (en) * 2020-02-10 2023-03-23 Amgen Inc. Omecamtiv mecarbil tablet
WO2021257456A1 (en) * 2020-06-15 2021-12-23 MyoKardia, Inc. Treatment of atrial dysfunction
KR20230107282A (ko) * 2020-11-12 2023-07-14 암젠 인크 오메캄티브 메카빌을 투여하여 심부전을 치료하는 방법
CN116710139A (zh) * 2020-11-12 2023-09-05 安进股份有限公司 通过施用奥美卡替莫卡必尔治疗心力衰竭的方法
BR112023018095A2 (pt) 2021-03-10 2023-12-12 Amgen Inc Processos para sintetizar 2-fluoro-3-nitrotolueno, 1-(bromometil)-2-fluoro-3-nitrobenzeno e para preparar omecamtiv mecarbil ou um sal do mesmo, um hidrato do mesmo ou um hidrato de sal do mesmo
WO2023164452A2 (en) * 2022-02-22 2023-08-31 Yale University Methods of treating, ameliorating, or preventing heart failure, and methods of promoting heart muscle growth
EP4594307A1 (en) 2022-09-26 2025-08-06 Edgewise Therapeutics, Inc. 1,4-dihydroquinazolinone compounds and uses thereof
WO2024081611A1 (en) * 2022-10-11 2024-04-18 Cytokinetics, Incorporated Methods for treating heart failure by administering cardiac sarcomere activators
AU2024248193A1 (en) 2023-03-27 2025-10-09 Edgewise Therapeutics, Inc. Quinolinone amide compounds and uses thereof
US11986474B1 (en) 2023-06-27 2024-05-21 Cytokinetics, Incorporated Methods for treating heart failure by administering cardiac sarcomere activators

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2014152236A1 (en) * 2013-03-14 2014-09-25 Amgen Inc. Heterocyclic compounds and their uses
WO2016210240A1 (en) * 2015-06-26 2016-12-29 Amgen Inc. Combination therapy of cardiac myosin activator and sinus node if current inhibitor

Family Cites Families (33)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4450150A (en) 1973-05-17 1984-05-22 Arthur D. Little, Inc. Biodegradable, implantable drug delivery depots, and method for preparing and using the same
CA2320193A1 (en) 1998-02-10 1999-08-19 Welfide Corporation Controlled release preparation
GB2344287A (en) 1998-12-03 2000-06-07 Ferring Bv Controlled release pharmaceutical formulation
WO2004033036A2 (en) 2002-10-04 2004-04-22 Microchips, Inc. Medical device for controlled drug delivery and cardiac monitoring and/or stimulation
PL216049B1 (pl) 2004-06-17 2014-02-28 Cytokinetics Inc Pochodne mocznika, kompozycje zawierajace pochodne mocznika oraz zastosowanie pochodnych mocznika do wytwarzania leku do leczenia niewydolnosci serca
US20070161617A1 (en) 2005-12-15 2007-07-12 Morgan Bradley P Certain chemical entities, compositions and methods
MX2008014418A (es) 2006-05-15 2008-11-27 Wisconsin Alumni Res Found Administracion pulmonar de la 1 alfa, 25-dihidroxivitamina d3 y co-administracion de la homona paratiroidea o calcitonina.
FR2902092B1 (fr) 2006-06-07 2008-09-05 Sapelem Soc Par Actions Simpli Appareil de manutention de charge
CN101657190B (zh) 2007-04-19 2013-09-11 东亚制药株式会社 一种适用于对葡萄糖控制肽进行控释的可生物降解的微球组合物及其制剂
EP2968180B1 (en) * 2013-03-14 2019-04-24 Amgen Inc. Heterocyclic compounds and their uses
EP3250557B1 (en) 2015-01-29 2024-11-20 Signal Pharmaceuticals, LLC Isotopologues of 2-(tert-butylamino)-4-((1r,3r,4r)-3-hydroxy-4-methylcyclohexylamino)-pyrimidine-5-carboxamide
WO2018144968A1 (en) 2017-02-06 2018-08-09 Acceleron Pharma Inc. Compositions and methods for treating heart failure
SI3645518T1 (sl) 2017-06-30 2021-11-30 Amgen Inc. Sinteza omekamtiv mekarbila
PL3645002T3 (pl) 2017-06-30 2025-03-24 Amgen Inc. Sposoby leczenia niewydolności serca za pomocą aktywatorów sarkomerów serca
PL3594199T3 (pl) 2018-07-09 2020-11-16 F.I.S.- Fabbrica Italiana Sintetici S.P.A. Krystaliczny 2-fluoro-3-nitrotoluen i sposób jego wytwarzania
EP3820851A1 (en) 2018-07-12 2021-05-19 Assia Chemical Industries Ltd Solid state forms of omecamtiv mecarbil & omecamtiv mecarbil dihcl
EP3599243B1 (en) 2018-07-26 2023-04-12 CVIE Therapeutics Limited 17beta-heterocyclyl-digitalis like compounds for the treatment of heart failure
US11465969B2 (en) 2018-08-17 2022-10-11 Cytokinetics, Inc. Salts and crystal forms of omecamtiv mecarbil
WO2020131574A1 (en) 2018-12-18 2020-06-25 Amgen Inc. Method of reducing aromatic nitro compounds
JP7560134B2 (ja) 2019-03-05 2024-10-02 ウインドトゥリー・セラピューティクス・インコーポレイテッド 急性心不全（ａｈｆ）の治療のためのイスタロキシム含有静脈用製剤
WO2021053189A1 (en) 2019-09-19 2021-03-25 Synthon B.V. Salts of omecamtiv mecarbil and solid forms thereof
WO2021053175A1 (en) 2019-09-19 2021-03-25 Synthon B.V. Salts of omecamtiv mecarbil and solid forms thereof
WO2021070124A1 (en) 2019-10-09 2021-04-15 Dr. Reddy’S Laboratories Limited Alternate processes for the preparation of omecamtiv mecarbil
WO2021070123A1 (en) 2019-10-09 2021-04-15 Dr. Reddy’S Laboratories Limited Solid forms of omecamtiv mecarbil dihydrochloride and processes thereof
BR112022008641A2 (pt) 2019-11-10 2022-09-13 Myokardia Inc Métodos de tratamento com modulador de miosina
GB201918853D0 (en) 2019-12-19 2020-02-05 Lund Lars H Methods of treatment
CN114929671B (zh) 2020-01-03 2024-04-16 苏州科睿思制药有限公司 化合物i二盐酸盐的共晶及其制备方法和用途
US20230090391A1 (en) 2020-02-10 2023-03-23 Amgen Inc. Omecamtiv mecarbil tablet
KR20230107282A (ko) 2020-11-12 2023-07-14 암젠 인크 오메캄티브 메카빌을 투여하여 심부전을 치료하는 방법
BR112023018095A2 (pt) 2021-03-10 2023-12-12 Amgen Inc Processos para sintetizar 2-fluoro-3-nitrotolueno, 1-(bromometil)-2-fluoro-3-nitrobenzeno e para preparar omecamtiv mecarbil ou um sal do mesmo, um hidrato do mesmo ou um hidrato de sal do mesmo
WO2023205291A2 (en) 2022-04-21 2023-10-26 The Board Of Regents Of The University Of Oklahoma Targeting myocardial tissue for delivery of therapeutic and imaging agents
WO2024081611A1 (en) 2022-10-11 2024-04-18 Cytokinetics, Incorporated Methods for treating heart failure by administering cardiac sarcomere activators
US11986474B1 (en) * 2023-06-27 2024-05-21 Cytokinetics, Incorporated Methods for treating heart failure by administering cardiac sarcomere activators

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2014152236A1 (en) * 2013-03-14 2014-09-25 Amgen Inc. Heterocyclic compounds and their uses
WO2016210240A1 (en) * 2015-06-26 2016-12-29 Amgen Inc. Combination therapy of cardiac myosin activator and sinus node if current inhibitor

Non-Patent Citations (3)

* Cited by examiner, † Cited by third party
Title
LICETTE CY LIU ET AL: "Omecamtiv mecarbil: a new cardiac myosin activator for the treatment of heart failure", EXPERT OPINION ON INVESTIGATIONAL DRUGS, vol. 25, no. 1, 19 December 2015 (2015-12-19), UK, pages 117 - 127, XP055507545, ISSN: 1354-3784, DOI: 10.1517/13543784.2016.1123248 *
TEERLINK JOHN R ET AL: "Acute Treatment With Omecamtiv Mecarbil to Increase Contractility in Acute Heart Failure The ATOMIC-AHF Study", JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY, ELSEVIER, NEW YORK, NY, US, vol. 67, no. 12, 21 March 2016 (2016-03-21), pages 1444 - 1455, XP029469242, ISSN: 0735-1097, DOI: 10.1016/J.JACC.2016.01.031 *
TEERLINK JOHN R ET AL: "Chronic Oral Study of Myosin Activation to Increase Contractility in Heart Failure (COSMIC-HF): a phase 2, pharmacokinetic, randomised, placebo-controlled trial", LANCET, ELSEVIER, AMSTERDAM, NL, vol. 388, no. 10062, 1 December 2016 (2016-12-01), pages 2895 - 2903, XP029843020, ISSN: 0140-6736, DOI: 10.1016/S0140-6736(16)32049-9 *

Also Published As

Publication number Publication date
US11576910B2 (en) 2023-02-14
US20230355615A1 (en) 2023-11-09
US20250255862A1 (en) 2025-08-14
AU2018290983B2 (en) 2023-11-23
RS66581B1 (sr) 2025-04-30
MX2022015115A (es) 2023-01-18
DK3645002T3 (da) 2024-12-16
HUE069805T2 (hu) 2025-04-28
PT3645002T (pt) 2025-01-24
MX2020000190A (es) 2020-07-22
WO2019006235A1 (en) 2019-01-03
US20230149394A1 (en) 2023-05-18
AU2024200991A1 (en) 2024-03-07
MA49508A (fr) 2020-05-06
AU2018290983A1 (en) 2020-01-23
BR112019028046A2 (pt) 2020-07-07
MA49508B1 (fr) 2024-12-31
FI3645002T3 (fi) 2025-01-29
SMT202500067T1 (it) 2025-03-12
EP3645002A1 (en) 2020-05-06
MD3645002T2 (ro) 2025-04-30
CN110996953A (zh) 2020-04-10
PL3645002T3 (pl) 2025-03-24
JP2023088944A (ja) 2023-06-27
US11931358B2 (en) 2024-03-19
EP4512470A2 (en) 2025-02-26
SI3645002T1 (sl) 2025-03-31
EP3645002B1 (en) 2024-10-30
LT3645002T (lt) 2025-02-10
JP2020526483A (ja) 2020-08-31
CA3068588A1 (en) 2019-01-03
ES3008457T3 (en) 2025-03-24
US12295952B2 (en) 2025-05-13
JP2025165979A (ja) 2025-11-05
AU2024200991B2 (en) 2025-04-10
US20200155547A1 (en) 2020-05-21
HRP20241729T1 (hr) 2025-03-14

Similar Documents

Publication Publication Date Title
EP4512470A3 (en) Methods of treating heart failure with cardiac sarcomere activators
EP3346915A4 (en) Systems, devices, components and methods for detecting the locations of sources of cardiac rhythm disorders in a patient's heart
EP2905951A3 (en) Synchronizing between image sequences of the heart acquired at different heartbeat rates
EP4344677A3 (en) Cinching of dilated heart muscle
CA2837341C (en) Method of determining vasoreactivity using inhaled nitric oxide
WO2016033197A3 (en) Medical device with triggered blanking period
WO2018217710A8 (en) Micro-nanobubble solutions for tissue preservation and generation thereof
WO2015191886A3 (en) Systems and methods for treating cardiac arrhythmias
MX390722B (es) Tratamiento de resistencia a diureticos.
WO2015106295A3 (en) Enolase 1 (eno1) compositions and uses thereof
TN2016000083A1 (en) Methods and tools relating to the administration of contrast medium
EA201592058A1 (ru) Применение ландиолола гидрохлорида в длительном лечении тахиаритмии
EP4252847A3 (en) Regimens and methods of treating multiple sclerosis using ofatumumab
MX2017011124A (es) Sistema medico modular para el monitoreo de pacientes y suministro de terapia electrica.
EP4487909A3 (en) Therapeutic uses of glucokinase activators in combination with insulin or insulin analogs
PH12015502037B1 (en) Activating adiponectin by casein hydrolysate
IL291412A (en) Androstane derivatives with activity as pure or mostly pure serca2a agonists for the treatment of heart failure
WO2009154758A3 (en) Cardiac rhythm management system with hemodynamic tolerability analyzer
Mount et al. Tissue-engineered cardiovascular grafts and novel applications of tissue engineering by self-assembly (tesa™)
SG10201903656RA (en) Pharmaceutical composition comprising a beta blocker and an angiotensin converting enzyme inhibitor
SG10201809418VA (en) New administration routes of insulin, insulin analogs or derivatives of insulin
ATE510585T1 (de) Aktive implantierbare medizinische herzvorrichtung mit antitachykarder vorhofstimulierung und antibradykarder ventrikelstimulierung
UA104808U (uk) Спосіб попередження спайкоутворення після оперативних втручань в гінекології
Reynolds Cardiac resynchronization for heart failure: Its time has come
UA90503U (uk) Спосіб лікування хронічної серцевої недостатності

Legal Events

Date Code Title Description
PUAI Public reference made under article 153(3) epc to a published international application that has entered the european phase

Free format text: ORIGINAL CODE: 0009012

STAA Information on the status of an ep patent application or granted ep patent

Free format text: STATUS: THE APPLICATION HAS BEEN PUBLISHED

AC Divisional application: reference to earlier application

Ref document number: 3645002

Country of ref document: EP

Kind code of ref document: P

AK Designated contracting states

Kind code of ref document: A2

Designated state(s): AL AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LI LT LU LV MC MK MT NL NO PL PT RO RS SE SI SK SM TR

REG Reference to a national code

Ref country code: DE

Ref legal event code: R079

Free format text: PREVIOUS MAIN CLASS: A61P0009040000

Ipc: A61K0031496000

PUAL Search report despatched

Free format text: ORIGINAL CODE: 0009013

AK Designated contracting states

Kind code of ref document: A3

Designated state(s): AL AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LI LT LU LV MC MK MT NL NO PL PT RO RS SE SI SK SM TR

RIC1 Information provided on ipc code assigned before grant

Ipc: A61P 9/04 20060101ALI20250320BHEP

Ipc: A61K 31/496 20060101AFI20250320BHEP

REG Reference to a national code

Ref country code: HK

Ref legal event code: DE

Ref document number: 40122094

Country of ref document: HK

STAA Information on the status of an ep patent application or granted ep patent

Free format text: STATUS: REQUEST FOR EXAMINATION WAS MADE

17P Request for examination filed

Effective date: 20251021