EP4339619A1 - Dispositif d'analyse automatique - Google Patents

Dispositif d'analyse automatique Download PDF

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Publication number
EP4339619A1
EP4339619A1 EP22807138.7A EP22807138A EP4339619A1 EP 4339619 A1 EP4339619 A1 EP 4339619A1 EP 22807138 A EP22807138 A EP 22807138A EP 4339619 A1 EP4339619 A1 EP 4339619A1
Authority
EP
European Patent Office
Prior art keywords
reaction container
reaction
disposal unit
lifting mechanism
automatic analyzer
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
EP22807138.7A
Other languages
German (de)
English (en)
Inventor
Sumiaki Matsuo
Shinya Matsuoka
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Hitachi High Tech Corp
Original Assignee
Hitachi High Tech Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hitachi High Tech Corp filed Critical Hitachi High Tech Corp
Publication of EP4339619A1 publication Critical patent/EP4339619A1/fr
Pending legal-status Critical Current

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Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N35/00—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor
    • G01N35/02—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor using a plurality of sample containers moved by a conveyor system past one or more treatment or analysis stations
    • G01N35/04—Details of the conveyor system
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N35/00—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N35/00—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor
    • G01N35/02—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor using a plurality of sample containers moved by a conveyor system past one or more treatment or analysis stations
    • G01N35/025—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor using a plurality of sample containers moved by a conveyor system past one or more treatment or analysis stations having a carousel or turntable for reaction cells or cuvettes
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N35/00—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor
    • G01N35/10—Devices for transferring samples or any liquids to, in, or from, the analysis apparatus, e.g. suction devices, injection devices
    • G01N35/1002—Reagent dispensers
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N35/00—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor
    • G01N35/02—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor using a plurality of sample containers moved by a conveyor system past one or more treatment or analysis stations
    • G01N35/04—Details of the conveyor system
    • G01N2035/0439—Rotary sample carriers, i.e. carousels
    • G01N2035/0443—Rotary sample carriers, i.e. carousels for reagents
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N35/00—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor
    • G01N35/02—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor using a plurality of sample containers moved by a conveyor system past one or more treatment or analysis stations
    • G01N35/04—Details of the conveyor system
    • G01N2035/046—General conveyor features
    • G01N2035/0465—Loading or unloading the conveyor

Definitions

  • the present invention relates to an automatic analyzer for conducting qualitative/quantitative analysis on a component of a biological sample such as blood and urine.
  • Patent Literature 1 discloses an automatic analyzer that includes: a reaction container disposal unit into which reaction containers after undergoing measurement are disposed of; a reaction container transfer mechanism that transfers the reaction containers from a reaction container holding unit to the reaction container disposal unit to dispose of the reaction containers into the reaction container disposal unit; and a control unit, in which the control unit controls operation of the reaction container transfer mechanism such that the reaction containers are not continuously disposed of in a predetermined position in the reaction container disposal unit.
  • Patent Literature 1 WO2017/047240
  • an automatic analyzer As apparatus for analyzing a target component contained in a sample, an automatic analyzer is widely known which measures the amount of light of transmitted light or scattered light of a single wavelength or a plurality of wavelengths obtained by applying light from a light source to a reaction liquid which is a mixture of a reagent and a sample to be analyzed.
  • the automatic analyzers include: apparatus for biochemical analysis used in qualitative, quantitative analysis on a target component in a biological sample such as in the area of biochemical test or hematological test and the like; apparatus for blood clotting analysis for measuring a clotting function of blood as a sample; and the like.
  • reaction containers in which reaction occurs between a sample and a reagent are sometimes disposed of after one use in order to prevent the effect on the analysis results due to unintended mixing between samples.
  • the used containers are required to be collected and discarded.
  • reaction containers are stacked on a specific place in the disposal unit.
  • a disposal hole is often designed to be smaller than an opening of the disposal unit in order to ensure a larger space in the apparatus design surface. Because of this, there is a trend for the reaction containers to be unevenly stacked directly below the disposal hole.
  • reaction containers are unevenly stacked within the disposal unit
  • the stacked reaction containers are likely to slip out of the disposal unit.
  • due to a residue of a sample remaining in the reaction container if an operator gathers the reaction containers, this may cause risks of causing secondary infection, and the like. Further, uneven stacking may incur a risk of blocking the disposal hole.
  • Patent Literature 1 as technologies for preventing the reaction containers and/or the like from being stacked in such a specific place, the technologies to displace the discarding position, provide a plurality of disposal holes, and the like are disclosed. However, it has been determined that due to apparatus layout constraints, there are room for further reduction in component count and more space savings.
  • an automatic analyzer includes: a plurality of reaction containers each configured to hold a reaction liquid; a reaction container tray lifting mechanism configured to convey a reaction container tray that holds the reaction containers before use; and a reaction container disposal unit to which the used reaction container is to be disposed of.
  • the reaction container disposal unit include a coupling portion configured to be able to contact the reaction container tray lifting mechanism and configured to convert an operation of the reaction container tray lifting mechanism into an exciting force exerted on the reaction container disposal unit.
  • stacking of the used reaction containers is able to be inhibited more easily than conventional analyzers, while the space savings may be maintained.
  • Fig. 1 is a plan view of the,automatic analyzer including a reagent disk (hereinafter sometimes referred to as a "reagent container holder” or a “drum”).
  • a reagent disk hereinafter sometimes referred to as a "reagent container holder” or a "drum”
  • up, down, left, right, front and rear directions are based on the up, down, left, right, front and rear directions shown in Fig. 1 .
  • a plurality of reagent containers (hereinafter sometimes referred to as “reagent containers”, “reagent bottles” or simply “bottles”) is placed along the inside of the outer peripheral wall of a cylindrical reagent disk 2 which is supported rotatably about the vertical axis, and the automatic analyzer 1 has a function to use a dispensing pipette-to aspirate a predetermined amount of predetermined reagent from each reagent bottle 3, and then to supply the aspirated reagent into a biological sample, such as blood and urine, dispensed into a reaction container, for analysis.
  • a biological sample such as blood and urine
  • a sample 5a to be analyzed is moved within the automatic analyzer 1 by a sample conveying mechanism 5, such as a conveyor belt, a rack handler or the like, and is conveyed to and dispensed by a sample dispensing mechanism 6 that includes a dispensing pipette for dispensing samples.
  • a sample conveying mechanism 5 such as a conveyor belt, a rack handler or the like
  • a sample dispensing mechanism 6 that includes a dispensing pipette for dispensing samples.
  • a plurality of reaction containers is placed on a reaction container tray 7, which then is supplied into the automatic analyzer 1.
  • the automatic analyzer 1 includes reaction container tray lifting mechanisms 21A, 21B that are mounted within a drawer 21 which is supported to be able to move horizontally from a closed position to a full open position via a front surface opening 20 formed in the front surface, a reaction container tray 7 (referred also to as a "holding member") or a plurality of reaction container trays 7 being able to be placed in the drawer 21.
  • a reaction container tray 7 (referred also to as a "holding member") or a plurality of reaction container trays 7 being able to be placed in the drawer 21.
  • the drawer 21 is pushed rearward to be closed, whereby the reaction container tray 7 may be supplied to the automatic analyzer 1 via the front surface opening 20.
  • the reaction container tray 7 supplied to the automatic analyzer 1 is exposed through the upper surface opening 10 toward a reaction container transfer mechanism 8.
  • a reaction container disposal unit 26 which will be described later is also placed.
  • the reaction container 14 is grasped one by one from the reaction container tray 7 by the reaction container transfer mechanism 8, and then is lifted up to move to an incubator 9 (referred sometimes to as a "culture disk").
  • the reaction container transfer mechanism 8 is configured to be able to move in directions of an X axis (left-right directions), of a Y axis (front-rear directions) and of a Z axis (up-down directions), and is configured to be movable, as its moving range, in a range above a reaction container disposal opening 12, a reaction liquid stirring mechanism 13, the reaction container tray 7 and part of the incubator 9.
  • the disk-shaped incubator 9 axially supported rotatably around a vertical central axis is configured to lock a plurality of reaction containers 14 on the circumference near the outer periphery, so that rotating the incubator 9 may move each of the reaction containers 14 to a predetermined position.
  • the sample dispensing mechanism 6 moves to an area above a sample to aspirate the sample, and then moves to an area above a reaction container 14 on the incubator 9 to discharge the sample into the reaction container 14. After that, the sample dispensing mechanism 6 cleans a nozzle of the dispensing pipette using a not-shown cleaning mechanism. If a replaceable tip, rather than the nozzle, is used, the tip may be replaced by a not-shown replacing mechanism.
  • a reagent disk 2 is formed in a cylindrical shape axially supported rotatably around a vertical central axis and also the inside thereof is hollowed out.
  • the reagent disk 2 has slots formed therein to hold a plurality of reagent bottles 3 in a radial fashion along an outer peripheral wall of the inner hollow. Rotating the reagent disk 2 causes each reagent bottle 3 to move to a predetermined position on the circumference. It is noted that some of the reagent bottles 3 contain a reagent including many magnetic particles for agitation. For controlling to maintain the reagent bottles 3 at constant temperature, the reagent disk 2 may have a thermal insulation function..
  • the reagent dispensing pipette 15 is configured movably such that it can move to a predetermined position after aspirating a reagent from the reagent bottle 3. Initially, after moving to an area above a predetermined type of reagent on the reagent disk 2 and then aspirating a predetermined amount of reagent, the reagent dispensing pipette 15 moves an area above a predetermined reaction container 14 on the incubator 9 and then discharges the reagent into the reaction container 14.
  • a reagent stirring mechanism 16 is placed above the reagent disk 2, a reagent stirring mechanism 16 is placed.
  • a magnetic particle stirring arm also called a "stirrer" which is ratable around a vertical axis .
  • the magnetic particle stirring arm moves to an area above the reagent bottle 3 containing the reagent with magnetic particles to be stirred.
  • a paddle-shaped or helical-shaped magnetic particle stirring mechanism mounted at a lower end of the magnetic particle stirring arm is moved down into the reagent, and the magnetic particle stirring mechanism is rotated in order to stir the magnetic particle solution.
  • the magnetic particle stirring arm stirs the magnetic particles immediately before the reagent is dispensed.
  • the magnetic particle stirring arm moves upward to above the reagent bottle 3, and then moves to an area above the cleaning mechanism 17 containing a cleaning fluid, and then moves downward into the cleaning fluid. Then, the magnetic particle stirring mechanism is rotated to remove the magnetic particles adhering to the stirring mechanism.
  • reaction liquid is formed.
  • the reaction liquid is aspirated from the reaction container 14 through the reaction liquid aspiration nozzle 18, and further supplied to the detection mechanism 19.
  • the detection mechanism 19 analyzes the reaction liquid.
  • reaction container 14 holding the analyzed reaction liquid is moved to an area above the reaction container disposal opening 12 by the reaction container transfer mechanism 8, and the reaction container 14 is disposed of through the reaction container disposal opening 12 in a reaction container disposal unit 26 ( Fig. 2 and the like).
  • the series of operations of the analyzer is controlled by a control unit 200.
  • the automatic analyzer is capable of analyzing a plurality of samples for a plurality of analysis items with efficiency by a combination or repetition of the above-described operations.
  • the automatic analyzer is not limited to taking a form of a single analysis module configuration as illustrated in Fig. 1 , and the automatic analyzer may be configured to connect two or more of analysis module (s) capable of measuring various same or different analysis items and/or pretreatment module(s) for conducting pretreatment through a convey apparatus(es) .
  • Fig. 2 is a diagram schematically showing a cross section (part of Section A-A' in Fig. 1 ) including the reaction container disposal unit in the automatic analyzer according to the first embodiment.
  • Fig. 3 is a diagram schematically showing the reaction container tray lifting mechanism and the reaction container disposal unit.
  • Fig. 4 is a top view showing a structure of a coupling portion on the reaction container disposal unit side.
  • Fig. 5 is a side view showing a structure of the coupling portion.
  • reaction container trays 7 loaded with unused reaction containers 14 are set in positions (reaction container standby portion 11) accessible by the reaction container transfer mechanism 8.
  • the reaction container transfer mechanism 8 removes the used reaction container tray 7 from the reaction container standby portion 11 by the lifting operation of the reaction container tray lifting mechanism 21B, and a reaction container tray 7 loaded with new unused reaction containers 14 is transferred to the reaction container standby portion 11 by the lifting operation of the reaction container tray lifting mechanism 21A and a reaction container tray moving mechanism which is not shown.
  • the reaction container disposal unit 26 has an opening formed in an upper portion thereof, and is configured to be mountable on a reaction container disposal unit holding member 25 that is placed directly below the reaction container disposal opening 12 illustrated in Fig. 1 .
  • reaction container disposal unit holding members 25 are arranged side by side, so that two reaction container disposal units 26 can be held within the analyzer.
  • the reaction container disposal units 26 are placed adjacent to the reaction container tray lifting mechanism 21B across the wall 23.
  • Two slits 24 are formed in the wall 23.
  • reaction container transfer mechanism 8 disposes of the reaction containers 14 in the same place at all times, the reaction containers 14 will be stacked in a fixed place within the reaction container disposal unit 26.
  • an L-shaped coupling member on disposal unit side 29 is arranged within each reaction container disposal unit holding member 25.
  • a protruding portion 30 protruding to be inserted into the slit 24 of the wall 23 as illustrated in Fig. 4 .
  • the protruding portion 30 has a portion protruding across the wall 23 toward the reaction container tray lifting mechanism 21B side, and in the portion, a connection member 31 and a protruding portion 32 are placed.
  • the reaction container tray lifting mechanism 21B is mounted with a coupling member on lifting mechanism side 27 that has projection portions 28 each placed on the protruding portion 32 side and in a position interfering with the protruding portion 32 of the coupling member on disposal unit side 29. Stated another way, the protruding portion 32 protrudes on the operation path of the reaction container tray lifting mechanism 21B.
  • the coupling member on disposal unit side 29 is configured to be able to contact the coupling member on lifting mechanism side 27 of the reaction container tray lifting mechanism 21B, which corresponding to a coupling member that converts an operation of the reaction container tray lifting mechanism 21B into an exciting force exerted on the reaction container disposal unit 26.
  • the projection portion 28 of the coupling member on lifting mechanism side 27 interferes with the protruding portion 32 as illustrated in Fig. 5 , so that the protruding portion 32 is rocked vertically and laterally.
  • the coupling member on disposal unit side 29 is also vibrated vertically and laterally via the protruding portion 32, the connection member 31 and the protruding portion 30 . That is, the coupling portion converts the lifting operation of the reaction container tray lifting mechanism 21B into the exciting force exerted on the reaction container disposal unit 26.
  • reaction container disposal unit 26 Since the reaction container disposal unit 26 is placed on the L-shaped coupling member on disposal unit side 29 as described above, upon vertical and lateral vibrations of the coupling member on disposal unit side 29, the reaction container disposal unit 26 also concurrently vibrates vertically and laterally. Because of this, even if the used reaction containers 14 are stacked unevenly in a certain place in the reaction container disposal unit 26, a pile of stacked used reaction containers 14 is deformed to be flat during the vibrations, so that the used reaction containers 14 become flat within the reaction container disposal unit 26.
  • reaction container tray lifting mechanism 21B Since the reaction container tray lifting mechanism 21B is driven by a dedicated motor, other than lifting up and down for collecting the used reaction container trays 7, the reaction container tray lifting mechanism 21B may be lifted up and down on a standalone basis for exciting the reaction container disposal unit 26. For the standalone operation, the reaction container tray lifting mechanism 21B is desirably lifted up and down without any effect on analysis.
  • the aforementioned automatic analyzer 1 includes: the plurality of reaction containers 14 each holding the reaction liquid; the reaction container tray lifting mechanism 21B that conveys the reaction container tray 7 holding the reaction containers 14 before use; and the reaction container disposal unit 26 to which the used reaction container 14 is to be disposed of.
  • the reaction container disposal unit 26 has a coupling portion that is configured to be able to contact the reaction container tray lifting mechanism 21B and converts an operation of the reaction container tray lifting mechanism 21B into an exciting force exerted on the reaction container disposal unit 26.
  • the stack unevenly piled in association with the operation of the reaction container tray lifting mechanism 21B may be flattened, so that unevenly stacking the reaction containers 14 may be more easily inhibited than conventional techniques. Also, by virtue of preventing uneven stacking in association with the operation of the reaction container tray lifting mechanism 21B, a required number of additional configurations is few, and the apparatus layout constraints may be minimized.
  • the coupling portion includes the protruding portion 32 that protrudes on the operation path of the reaction container tray lifting mechanism 21B. This may easily achieve a structure facilitating conversion from the operation of the reaction container tray lifting mechanism 21B to the exciting force.
  • reaction container tray lifting mechanism 21B is placed adjacent to the reaction container disposal unit 26, and the coupling portion converts the lifting operation of the reaction container tray lifting mechanism 21B into the exciting force exerted on the reaction container disposal unit 26. Thereby, the structure of the coupling portion may be minimized in size.
  • FIG. 6 is a top view showing a structure of a coupling portion on the reaction container disposal unit side in the automatic analyzer according to the second embodiment.
  • Fig. 7 is a side view showing the structure of the coupling portion.
  • the automatic analyzer according to the embodiment is identical in structure, operation with the first embodiment other than differs in the structure of the coupling portion from the first embodiment, and details thereof are omitted.
  • a coupling member on disposal unit side 29A in the automatic analyzer according to the embodiment is arranged within the reaction container disposal unit holding member 25, but a protruding portion 30A is placed to protrude toward the slit 24. Further, a gear 31A is placed on a portion of the protruding portion 30A protruding across the wall 23 to the reaction container tray lifting mechanism 21B side.
  • the reaction container tray lifting mechanism 21B is attached with a coupling member on lifting mechanism side 27A in a position interfering with the gear 31A of the protruding portion 30A of the coupling member on disposal unit side 29A. Stated another way, the protruding portion 30A protrudes on the operation path of the reaction container tray lifting mechanism 21B.
  • the coupling member on lifting mechanism side 27A interferes with the gear 31A as illustrated in Fig. 7 , so that the protruding portion 30A is rocked vertically and laterally via the gear 31A.
  • the coupling member on disposal unit side 29A also vibrates vertically and laterally, and concurrently the reaction container disposal unit 26 also vibrates vertically and laterally.
  • a part of the configuration of one embodiment can be substituted for a configuration of another embodiment, and a configuration of one embodiment can be added to a configuration of another embodiment. Further, for a portion of the configuration of each embodiment, addition, deletion and substitution of another configuration may be made.

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  • Chemical & Material Sciences (AREA)
  • Physics & Mathematics (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Analytical Chemistry (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • General Physics & Mathematics (AREA)
  • Immunology (AREA)
  • Pathology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Automatic Analysis And Handling Materials Therefor (AREA)
EP22807138.7A 2021-05-10 2022-03-10 Dispositif d'analyse automatique Pending EP4339619A1 (fr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP2021079967 2021-05-10
PCT/JP2022/010485 WO2022239431A1 (fr) 2021-05-10 2022-03-10 Dispositif d'analyse automatique

Publications (1)

Publication Number Publication Date
EP4339619A1 true EP4339619A1 (fr) 2024-03-20

Family

ID=84029143

Family Applications (1)

Application Number Title Priority Date Filing Date
EP22807138.7A Pending EP4339619A1 (fr) 2021-05-10 2022-03-10 Dispositif d'analyse automatique

Country Status (5)

Country Link
US (1) US20240192242A1 (fr)
EP (1) EP4339619A1 (fr)
JP (1) JP7490893B2 (fr)
CN (1) CN117203531A (fr)
WO (1) WO2022239431A1 (fr)

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH03170062A (ja) * 1989-11-28 1991-07-23 Seiko Instr Inc 自動化学処理装置
JPH09127127A (ja) * 1995-10-31 1997-05-16 Hitachi Ltd 使い捨てチップの回収装置
JP5467954B2 (ja) * 2010-07-12 2014-04-09 日立アロカメディカル株式会社 ノズルチップ検出装置
CN108027380B (zh) 2015-09-17 2020-10-09 株式会社日立高新技术 自动分析装置
DE212018000219U1 (de) * 2017-05-12 2020-01-09 Thermo Fisher Scientific Oy System zum Entsorgen einer Reihe von Aufnahmebehältern

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Publication number Publication date
US20240192242A1 (en) 2024-06-13
JPWO2022239431A1 (fr) 2022-11-17
CN117203531A (zh) 2023-12-08
JP7490893B2 (ja) 2024-05-27
WO2022239431A1 (fr) 2022-11-17

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