EP4201481A4 - Ultraschall- und mikroblasengestütztes ballonkathetersystem und gefässdilatationsverfahren damit - Google Patents

Ultraschall- und mikroblasengestütztes ballonkathetersystem und gefässdilatationsverfahren damit Download PDF

Info

Publication number
EP4201481A4
EP4201481A4 EP21860366.0A EP21860366A EP4201481A4 EP 4201481 A4 EP4201481 A4 EP 4201481A4 EP 21860366 A EP21860366 A EP 21860366A EP 4201481 A4 EP4201481 A4 EP 4201481A4
Authority
EP
European Patent Office
Prior art keywords
microbubble
ultrasound
same
balloon catheter
catheter system
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
EP21860366.0A
Other languages
English (en)
French (fr)
Other versions
EP4201481A1 (de
Inventor
Chih-Kuang Yeh
Chieh-Yu Tsai
Jen-Kuang Lee
Chun-Yen Lai
Zong-Han Hsieh
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Tsinghua University
Original Assignee
Tsinghua University
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Tsinghua University filed Critical Tsinghua University
Publication of EP4201481A1 publication Critical patent/EP4201481A1/de
Publication of EP4201481A4 publication Critical patent/EP4201481A4/de
Pending legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B17/00—Surgical instruments, devices or methods
    • A61B17/22—Implements for squeezing-off ulcers or the like on inner organs of the body; Implements for scraping-out cavities of body organs, e.g. bones; for invasive removal or destruction of calculus using mechanical vibrations; for removing obstructions in blood vessels, not otherwise provided for
    • A61B17/22004—Implements for squeezing-off ulcers or the like on inner organs of the body; Implements for scraping-out cavities of body organs, e.g. bones; for invasive removal or destruction of calculus using mechanical vibrations; for removing obstructions in blood vessels, not otherwise provided for using mechanical vibrations, e.g. ultrasonic shock waves
    • A61B17/22012—Implements for squeezing-off ulcers or the like on inner organs of the body; Implements for scraping-out cavities of body organs, e.g. bones; for invasive removal or destruction of calculus using mechanical vibrations; for removing obstructions in blood vessels, not otherwise provided for using mechanical vibrations, e.g. ultrasonic shock waves in direct contact with, or very close to, the obstruction or concrement
    • A61B17/2202—Implements for squeezing-off ulcers or the like on inner organs of the body; Implements for scraping-out cavities of body organs, e.g. bones; for invasive removal or destruction of calculus using mechanical vibrations; for removing obstructions in blood vessels, not otherwise provided for using mechanical vibrations, e.g. ultrasonic shock waves in direct contact with, or very close to, the obstruction or concrement the ultrasound transducer being inside patient's body at the distal end of the catheter
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B17/00—Surgical instruments, devices or methods
    • A61B17/22—Implements for squeezing-off ulcers or the like on inner organs of the body; Implements for scraping-out cavities of body organs, e.g. bones; for invasive removal or destruction of calculus using mechanical vibrations; for removing obstructions in blood vessels, not otherwise provided for
    • A61B17/22004—Implements for squeezing-off ulcers or the like on inner organs of the body; Implements for scraping-out cavities of body organs, e.g. bones; for invasive removal or destruction of calculus using mechanical vibrations; for removing obstructions in blood vessels, not otherwise provided for using mechanical vibrations, e.g. ultrasonic shock waves
    • A61B17/22012—Implements for squeezing-off ulcers or the like on inner organs of the body; Implements for scraping-out cavities of body organs, e.g. bones; for invasive removal or destruction of calculus using mechanical vibrations; for removing obstructions in blood vessels, not otherwise provided for using mechanical vibrations, e.g. ultrasonic shock waves in direct contact with, or very close to, the obstruction or concrement
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K41/00—Medicinal preparations obtained by treating materials with wave energy or particle radiation ; Therapies using these preparations
    • A61K41/0028—Disruption, e.g. by heat or ultrasounds, sonophysical or sonochemical activation, e.g. thermosensitive or heat-sensitive liposomes, disruption of calculi with a medicinal preparation and ultrasounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B17/00—Surgical instruments, devices or methods
    • A61B17/22—Implements for squeezing-off ulcers or the like on inner organs of the body; Implements for scraping-out cavities of body organs, e.g. bones; for invasive removal or destruction of calculus using mechanical vibrations; for removing obstructions in blood vessels, not otherwise provided for
    • A61B17/22004—Implements for squeezing-off ulcers or the like on inner organs of the body; Implements for scraping-out cavities of body organs, e.g. bones; for invasive removal or destruction of calculus using mechanical vibrations; for removing obstructions in blood vessels, not otherwise provided for using mechanical vibrations, e.g. ultrasonic shock waves
    • A61B2017/22005—Effects, e.g. on tissue
    • A61B2017/22007—Cavitation or pseudocavitation, i.e. creation of gas bubbles generating a secondary shock wave when collapsing
    • A61B2017/22008—Cavitation or pseudocavitation, i.e. creation of gas bubbles generating a secondary shock wave when collapsing used or promoted
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B17/00—Surgical instruments, devices or methods
    • A61B17/22—Implements for squeezing-off ulcers or the like on inner organs of the body; Implements for scraping-out cavities of body organs, e.g. bones; for invasive removal or destruction of calculus using mechanical vibrations; for removing obstructions in blood vessels, not otherwise provided for
    • A61B2017/22051—Implements for squeezing-off ulcers or the like on inner organs of the body; Implements for scraping-out cavities of body organs, e.g. bones; for invasive removal or destruction of calculus using mechanical vibrations; for removing obstructions in blood vessels, not otherwise provided for with an inflatable part, e.g. balloon, for positioning, blocking, or immobilisation
    • A61B2017/22062—Implements for squeezing-off ulcers or the like on inner organs of the body; Implements for scraping-out cavities of body organs, e.g. bones; for invasive removal or destruction of calculus using mechanical vibrations; for removing obstructions in blood vessels, not otherwise provided for with an inflatable part, e.g. balloon, for positioning, blocking, or immobilisation to be filled with liquid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B17/00—Surgical instruments, devices or methods
    • A61B17/22—Implements for squeezing-off ulcers or the like on inner organs of the body; Implements for scraping-out cavities of body organs, e.g. bones; for invasive removal or destruction of calculus using mechanical vibrations; for removing obstructions in blood vessels, not otherwise provided for
    • A61B2017/22051—Implements for squeezing-off ulcers or the like on inner organs of the body; Implements for scraping-out cavities of body organs, e.g. bones; for invasive removal or destruction of calculus using mechanical vibrations; for removing obstructions in blood vessels, not otherwise provided for with an inflatable part, e.g. balloon, for positioning, blocking, or immobilisation
    • A61B2017/22065—Functions of balloons
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B17/00—Surgical instruments, devices or methods
    • A61B17/22—Implements for squeezing-off ulcers or the like on inner organs of the body; Implements for scraping-out cavities of body organs, e.g. bones; for invasive removal or destruction of calculus using mechanical vibrations; for removing obstructions in blood vessels, not otherwise provided for
    • A61B2017/22082—Implements for squeezing-off ulcers or the like on inner organs of the body; Implements for scraping-out cavities of body organs, e.g. bones; for invasive removal or destruction of calculus using mechanical vibrations; for removing obstructions in blood vessels, not otherwise provided for after introduction of a substance
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B17/00—Surgical instruments, devices or methods
    • A61B17/22—Implements for squeezing-off ulcers or the like on inner organs of the body; Implements for scraping-out cavities of body organs, e.g. bones; for invasive removal or destruction of calculus using mechanical vibrations; for removing obstructions in blood vessels, not otherwise provided for
    • A61B2017/22082—Implements for squeezing-off ulcers or the like on inner organs of the body; Implements for scraping-out cavities of body organs, e.g. bones; for invasive removal or destruction of calculus using mechanical vibrations; for removing obstructions in blood vessels, not otherwise provided for after introduction of a substance
    • A61B2017/22088—Implements for squeezing-off ulcers or the like on inner organs of the body; Implements for scraping-out cavities of body organs, e.g. bones; for invasive removal or destruction of calculus using mechanical vibrations; for removing obstructions in blood vessels, not otherwise provided for after introduction of a substance ultrasound absorbing, drug activated by ultrasound
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B17/00—Surgical instruments, devices or methods
    • A61B17/22—Implements for squeezing-off ulcers or the like on inner organs of the body; Implements for scraping-out cavities of body organs, e.g. bones; for invasive removal or destruction of calculus using mechanical vibrations; for removing obstructions in blood vessels, not otherwise provided for
    • A61B2017/22082—Implements for squeezing-off ulcers or the like on inner organs of the body; Implements for scraping-out cavities of body organs, e.g. bones; for invasive removal or destruction of calculus using mechanical vibrations; for removing obstructions in blood vessels, not otherwise provided for after introduction of a substance
    • A61B2017/22089—Gas-bubbles

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Surgery (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Medical Informatics (AREA)
  • Molecular Biology (AREA)
  • Biomedical Technology (AREA)
  • Vascular Medicine (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Mechanical Engineering (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Surgical Instruments (AREA)
EP21860366.0A 2020-08-24 2021-08-24 Ultraschall- und mikroblasengestütztes ballonkathetersystem und gefässdilatationsverfahren damit Pending EP4201481A4 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US202063069190P 2020-08-24 2020-08-24
PCT/CN2021/114261 WO2022042531A1 (zh) 2020-08-24 2021-08-24 超声波搭配微气泡辅助的气球导管系统及其血管扩张方法

Publications (2)

Publication Number Publication Date
EP4201481A1 EP4201481A1 (de) 2023-06-28
EP4201481A4 true EP4201481A4 (de) 2024-12-18

Family

ID=80269103

Family Applications (1)

Application Number Title Priority Date Filing Date
EP21860366.0A Pending EP4201481A4 (de) 2020-08-24 2021-08-24 Ultraschall- und mikroblasengestütztes ballonkathetersystem und gefässdilatationsverfahren damit

Country Status (5)

Country Link
US (1) US12023055B2 (de)
EP (1) EP4201481A4 (de)
CN (1) CN116056759A (de)
TW (1) TWI810633B (de)
WO (1) WO2022042531A1 (de)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN116942246A (zh) * 2022-04-13 2023-10-27 深圳高性能医疗器械国家研究院有限公司 用于血管成形术的爆裂波发生方法及爆裂波发生系统
CN114886504A (zh) * 2022-05-30 2022-08-12 苏州润迈德医疗科技有限公司 一种可成像的冲击波碎石球囊导管及其使用方法
WO2024075048A1 (en) * 2022-10-04 2024-04-11 Otsuka Medical Devices Co., Ltd. Devices, methods and systems for renal denervation
TWI866877B (zh) * 2023-08-17 2024-12-11 國立清華大學 超音波球囊導管
CN121772877A (zh) * 2023-08-17 2026-03-31 叶秩光 导管用超声波侦测辅助系统及其方法
TWI884114B (zh) * 2024-11-28 2025-05-11 財團法人金屬工業研究發展中心 超音波深度探測裝置

Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20120209116A1 (en) * 2009-07-21 2012-08-16 Hossack John A Systems and Methods for Ultrasound Imaging and Insonation of Microbubbles
US20130023897A1 (en) * 2009-10-06 2013-01-24 Michael P Wallace Devices and Methods for Endovascular Therapies
WO2013119662A1 (en) * 2012-02-06 2013-08-15 Cornell University Catheter based system and method for thrombus removal using time reversal acoustics
US20140039358A1 (en) * 2012-08-03 2014-02-06 Muffin Incorporated Weeping balloon catheter with ultrasound element
US20160375235A1 (en) * 2015-06-25 2016-12-29 Cardiovascular Systems, Inc. Devices, systems and methods for enhancing intraluminal drug delivery and uptake

Family Cites Families (38)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4841977A (en) * 1987-05-26 1989-06-27 Inter Therapy, Inc. Ultra-thin acoustic transducer and balloon catheter using same in imaging array subassembly
DE69432148T2 (de) * 1993-07-01 2003-10-16 Boston Scientific Ltd., St. Michael Katheter zur bilddarstellung, zur anzeige elektrischer signale und zur ablation
ATE246920T1 (de) * 1994-10-03 2003-08-15 Infectio Recherche Inc Liposomenzubereitungen zur behandlung von viruserkrankungen
US20040019318A1 (en) * 2001-11-07 2004-01-29 Wilson Richard R. Ultrasound assembly for use with a catheter
US20070010702A1 (en) * 2003-04-08 2007-01-11 Xingwu Wang Medical device with low magnetic susceptibility
CN1298400C (zh) 2003-09-01 2007-02-07 吴巍 超声微泡造影剂用于形成毛细血管栓塞的医疗装置
US20080177180A1 (en) 2004-08-17 2008-07-24 Technion Research & Development Ultrasonic Image-Guided Tissue-Damaging Procedure
US20060241524A1 (en) 2005-03-11 2006-10-26 Qi Yu Intravascular ultrasound catheter device and method for ablating atheroma
US7591996B2 (en) 2005-08-17 2009-09-22 University Of Washington Ultrasound target vessel occlusion using microbubbles
US7942850B2 (en) * 2006-10-13 2011-05-17 Endocross Ltd. Balloons and balloon catheter systems for treating vascular occlusions
EP2200652B1 (de) * 2007-09-27 2018-03-21 Children's Medical Center Corporation Mikrobläschen und sauerstoffabgabe-verfahren
WO2009059449A1 (en) 2007-11-05 2009-05-14 Celsion Corporation Novel thermosensitive liposomes containing therapeutic agents
JP4734448B2 (ja) * 2009-12-04 2011-07-27 株式会社日立製作所 超音波治療装置
WO2011094379A1 (en) * 2010-01-28 2011-08-04 Cook Medical Technologies Llc Apparatus and method for destruction of vascular thrombus
US8740835B2 (en) * 2010-02-17 2014-06-03 Ekos Corporation Treatment of vascular occlusions using ultrasonic energy and microbubbles
CN102475682B (zh) 2010-11-30 2013-03-13 沈阳药科大学 小檗碱脂质体及其制备方法
WO2012162664A1 (en) * 2011-05-26 2012-11-29 The Trustees Of Columbia University In The City Of New York Systems and methods for opening of a tissue barrier in primates
US20130331738A1 (en) * 2012-06-11 2013-12-12 Board Of Trustees University Of Arkansas Compositions and methods for potentiating sonothrombolysis
US9610380B2 (en) * 2014-06-26 2017-04-04 DePuy Synthes Products, Inc. Vertebral body augmentation systems comprising microbubbles
US11478618B2 (en) 2015-03-26 2022-10-25 Vensica Medical Ltd. Ultrasonic urinary bladder drug delivery
AU2017213791B2 (en) 2016-02-01 2023-10-19 Trust Biosonics Inc. Lipid microbubbles and process of making thereof
CN205548629U (zh) 2016-03-24 2016-09-07 广州军区广州总医院 一种超声微泡空化溶栓系统
TW201740884A (zh) * 2016-05-23 2017-12-01 佳世達科技股份有限公司 超音波導管及醫療系統
CN105852911B (zh) * 2016-05-26 2019-11-29 苏州佳世达电通有限公司 超音波导管及医疗系统
US10232161B2 (en) * 2016-09-13 2019-03-19 National Tsing Hua University Ultrasonic device for transversely manipulating drug delivery carriers and method using the same
US10945634B2 (en) * 2016-09-22 2021-03-16 Walter Kusumoto Modular electrophysiology mapping system and method
EP3565484B1 (de) 2017-01-05 2024-04-03 Contraline, Inc. Zusammensetzungen zur implantation und umkehrung von auf stimuli reagierenden implantaten
US10856893B2 (en) * 2017-04-21 2020-12-08 Boston Scientific Scimed, Inc. Lithotripsy angioplasty devices and methods
EP3638021B1 (de) * 2017-06-14 2025-01-22 University of Louisville Research Foundation Verfahren zur konservierung von zellen
CN111886002A (zh) * 2018-03-20 2020-11-03 百奥医福股份有限公司 一种包括用于递送药物的超声响应性微泡的脂质体的制备方法以及使用该方法的脂质体
CN110548140B (zh) 2018-06-01 2022-03-15 叶秩光 带氧微气泡用于制备诱导病变组织血管正常化套组的用途
TWI720319B (zh) * 2018-06-12 2021-03-01 國立清華大學 超音波感應蛋白質以及利用超音波刺激細胞的方法
US11793863B2 (en) * 2019-04-26 2023-10-24 University of Pittsburgh—of the Commonwealth System of Higher Education Functionalized microbubble embodiments for ultrasound-mediated treatment and methods of making and using the same
CN110237256A (zh) 2019-07-22 2019-09-17 重庆医科大学 一种载n2o微泡及其制备方法与应用
CN110811762A (zh) 2019-08-08 2020-02-21 谱创医疗科技(上海)有限公司 冲击波增强型药物输送导管
US20220401574A1 (en) * 2019-11-15 2022-12-22 University Of Pittsburgh - Of The Commonwealth System Of Higher Education Cardioprotective microbubble-liposomal drug complexes
US11672599B2 (en) * 2020-03-09 2023-06-13 Bolt Medical, Inc. Acoustic performance monitoring system and method within intravascular lithotripsy device
CN111568500A (zh) 2020-05-26 2020-08-25 王志玉 一种用于心血管狭窄病变的血管再通系统

Patent Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20120209116A1 (en) * 2009-07-21 2012-08-16 Hossack John A Systems and Methods for Ultrasound Imaging and Insonation of Microbubbles
US20130023897A1 (en) * 2009-10-06 2013-01-24 Michael P Wallace Devices and Methods for Endovascular Therapies
WO2013119662A1 (en) * 2012-02-06 2013-08-15 Cornell University Catheter based system and method for thrombus removal using time reversal acoustics
US20140039358A1 (en) * 2012-08-03 2014-02-06 Muffin Incorporated Weeping balloon catheter with ultrasound element
US20160375235A1 (en) * 2015-06-25 2016-12-29 Cardiovascular Systems, Inc. Devices, systems and methods for enhancing intraluminal drug delivery and uptake

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
See also references of WO2022042531A1 *

Also Published As

Publication number Publication date
US20220054155A1 (en) 2022-02-24
WO2022042531A1 (zh) 2022-03-03
US12023055B2 (en) 2024-07-02
EP4201481A1 (de) 2023-06-28
CN116056759A (zh) 2023-05-02
TW202207876A (zh) 2022-03-01
TWI810633B (zh) 2023-08-01

Similar Documents

Publication Publication Date Title
DE602004029155D1 (de) Dilatations- und stentablagesystem
MX2022004539A (es) Cateteres centrales insertables rapidamente y sus metodos.
DE60216271D1 (de) Vorrichtungen zum schutz vor emboli
US6689119B1 (en) Self-aligning medical device
BR112022007103A2 (pt) Cateteres centrais de inserção rápida e métodos dos mesmos
ATE392864T1 (de) Mit einer rauhen oberfläche versehener stent und sein herstellungsverfahren
DE69827806D1 (de) Ballonkatheter
CN1334747A (zh) 治疗劲动脉狭窄的血管内膜炎系统及该系统的导液管
DE502007004507D1 (de) Vorrichtung zur verringerung oder entfernung von stenosen
MX2023006600A (es) Dilatacion pasiva en los sistemas de insercion de cateteres.
WO2007041542A3 (en) Systems and methods for analysis and treatment of a body lumen
WO2005028015A3 (en) Methods and apparatus for localized and semi-localized drug delivery
DE60235176D1 (de) Nachgiebige ballons
ATE543533T1 (de) Vorrichtung zur behandlung von sinusitis
ATE406187T1 (de) Katheteranordnung zur arzneimittelabgabe mit aufblasbarem ballon
DE60309745D1 (de) Schnellwechseldilatationskatheter für nicht vaskuläre anwendungen
ATE427131T1 (de) Kathetersystem und verfahren zum íffnen von okklusionen der blutgefasse
WO2005046757A3 (en) Catheter balloon systems and methods
CN1662182A (zh) 吸引导管
WO2008001242A3 (en) Phototherapy device
EP3932287A4 (de) Mla-oct-bildgebungskatheter, mla-oct-bildgebungssystem und mla-oct-bildgebungsverfahren
EP4299035A4 (de) Einführkatheter, implantateinführungssystem und arbeitsverfahren
EP4129388A4 (de) Ballonkatheter und ballonkathetersystem
EP4346976A4 (de) Harnkathetersystem und verfahren zur selbstkatheterisierung und urinextraktion
ATE516783T1 (de) Abgabe einer gekühlten flüssigkeit an stellen im körperinneren

Legal Events

Date Code Title Description
STAA Information on the status of an ep patent application or granted ep patent

Free format text: STATUS: THE INTERNATIONAL PUBLICATION HAS BEEN MADE

PUAI Public reference made under article 153(3) epc to a published international application that has entered the european phase

Free format text: ORIGINAL CODE: 0009012

STAA Information on the status of an ep patent application or granted ep patent

Free format text: STATUS: REQUEST FOR EXAMINATION WAS MADE

17P Request for examination filed

Effective date: 20230316

AK Designated contracting states

Kind code of ref document: A1

Designated state(s): AL AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LI LT LU LV MC MK MT NL NO PL PT RO RS SE SI SK SM TR

DAV Request for validation of the european patent (deleted)
DAX Request for extension of the european patent (deleted)
REG Reference to a national code

Ref country code: DE

Ref legal event code: R079

Free format text: PREVIOUS MAIN CLASS: A61N0007000000

Ipc: A61B0017220000

RIC1 Information provided on ipc code assigned before grant

Ipc: A61K 41/00 20200101ALI20240822BHEP

Ipc: A61B 17/22 20060101AFI20240822BHEP

A4 Supplementary search report drawn up and despatched

Effective date: 20241118

RIC1 Information provided on ipc code assigned before grant

Ipc: A61K 41/00 20200101ALI20241112BHEP

Ipc: A61B 17/22 20060101AFI20241112BHEP