EP4161475A1 - Ökobiologische fett-alkohol-zusammensetzung - Google Patents
Ökobiologische fett-alkohol-zusammensetzungInfo
- Publication number
- EP4161475A1 EP4161475A1 EP20767531.5A EP20767531A EP4161475A1 EP 4161475 A1 EP4161475 A1 EP 4161475A1 EP 20767531 A EP20767531 A EP 20767531A EP 4161475 A1 EP4161475 A1 EP 4161475A1
- Authority
- EP
- European Patent Office
- Prior art keywords
- ecobiological
- lipoalcoholic
- composition according
- advantageously
- topical composition
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
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- 239000006071 cream Substances 0.000 description 1
- SASYSVUEVMOWPL-NXVVXOECSA-N decyl oleate Chemical compound CCCCCCCCCCOC(=O)CCCCCCC\C=C/CCCCCCCC SASYSVUEVMOWPL-NXVVXOECSA-N 0.000 description 1
- 230000018044 dehydration Effects 0.000 description 1
- 238000006297 dehydration reaction Methods 0.000 description 1
- 230000035618 desquamation Effects 0.000 description 1
- 229940100539 dibutyl adipate Drugs 0.000 description 1
- 229940031569 diisopropyl sebacate Drugs 0.000 description 1
- PKPOVTYZGGYDIJ-UHFFFAOYSA-N dioctyl carbonate Chemical compound CCCCCCCCOC(=O)OCCCCCCCC PKPOVTYZGGYDIJ-UHFFFAOYSA-N 0.000 description 1
- XFKBBSZEQRFVSL-UHFFFAOYSA-N dipropan-2-yl decanedioate Chemical compound CC(C)OC(=O)CCCCCCCCC(=O)OC(C)C XFKBBSZEQRFVSL-UHFFFAOYSA-N 0.000 description 1
- DLAHAXOYRFRPFQ-UHFFFAOYSA-N dodecyl benzoate Chemical compound CCCCCCCCCCCCOC(=O)C1=CC=CC=C1 DLAHAXOYRFRPFQ-UHFFFAOYSA-N 0.000 description 1
- XJFGDLJQUJQUEI-UHFFFAOYSA-N dodecyl decanoate dodecyl octanoate Chemical compound CCCCCCCCCCCCOC(=O)CCCCCCC.CCCCCCCCCCCCOC(=O)CCCCCCCCC XJFGDLJQUJQUEI-UHFFFAOYSA-N 0.000 description 1
- 229960003913 econazole Drugs 0.000 description 1
- 235000013399 edible fruits Nutrition 0.000 description 1
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- BLCTWBJQROOONQ-UHFFFAOYSA-N ethenyl prop-2-enoate Chemical compound C=COC(=O)C=C BLCTWBJQROOONQ-UHFFFAOYSA-N 0.000 description 1
- GJQLBGWSDGMZKM-UHFFFAOYSA-N ethylhexyl palmitate Chemical compound CCCCCCCCCCCCCCCC(=O)OC(CC)CCCCC GJQLBGWSDGMZKM-UHFFFAOYSA-N 0.000 description 1
- 238000011156 evaluation Methods 0.000 description 1
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- 230000008020 evaporation Effects 0.000 description 1
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- PMMXXYHTOMKOAZ-UHFFFAOYSA-N hexadecyl 7-methyloctanoate Chemical compound CCCCCCCCCCCCCCCCOC(=O)CCCCCC(C)C PMMXXYHTOMKOAZ-UHFFFAOYSA-N 0.000 description 1
- 229940100463 hexyl laurate Drugs 0.000 description 1
- 230000001939 inductive effect Effects 0.000 description 1
- 239000005550 inflammation mediator Substances 0.000 description 1
- 208000014674 injury Diseases 0.000 description 1
- VKPSKYDESGTTFR-UHFFFAOYSA-N isododecane Natural products CC(C)(C)CC(C)CC(C)(C)C VKPSKYDESGTTFR-UHFFFAOYSA-N 0.000 description 1
- KUVMKLCGXIYSNH-UHFFFAOYSA-N isopentadecane Natural products CCCCCCCCCCCCC(C)C KUVMKLCGXIYSNH-UHFFFAOYSA-N 0.000 description 1
- 230000003902 lesion Effects 0.000 description 1
- 239000006210 lotion Substances 0.000 description 1
- 210000004379 membrane Anatomy 0.000 description 1
- 239000012528 membrane Substances 0.000 description 1
- 230000008384 membrane barrier Effects 0.000 description 1
- 238000000034 method Methods 0.000 description 1
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 description 1
- 230000003020 moisturizing effect Effects 0.000 description 1
- 210000004400 mucous membrane Anatomy 0.000 description 1
- JXTPJDDICSTXJX-UHFFFAOYSA-N n-Triacontane Natural products CCCCCCCCCCCCCCCCCCCCCCCCCCCCCC JXTPJDDICSTXJX-UHFFFAOYSA-N 0.000 description 1
- 230000037125 natural defense Effects 0.000 description 1
- WWZKQHOCKIZLMA-UHFFFAOYSA-N octanoic acid Chemical compound CCCCCCCC(O)=O WWZKQHOCKIZLMA-UHFFFAOYSA-N 0.000 description 1
- 239000012188 paraffin wax Substances 0.000 description 1
- 244000052769 pathogen Species 0.000 description 1
- 230000000149 penetrating effect Effects 0.000 description 1
- 230000035515 penetration Effects 0.000 description 1
- 239000000825 pharmaceutical preparation Substances 0.000 description 1
- 229940127557 pharmaceutical product Drugs 0.000 description 1
- 229920000058 polyacrylate Polymers 0.000 description 1
- 229940048845 polyglyceryl-3 diisostearate Drugs 0.000 description 1
- 229920000036 polyvinylpyrrolidone Polymers 0.000 description 1
- 238000004321 preservation Methods 0.000 description 1
- 230000002265 prevention Effects 0.000 description 1
- 230000008569 process Effects 0.000 description 1
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- 230000001105 regulatory effect Effects 0.000 description 1
- 210000000614 rib Anatomy 0.000 description 1
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- 230000037380 skin damage Effects 0.000 description 1
- 231100000444 skin lesion Toxicity 0.000 description 1
- 206010040882 skin lesion Diseases 0.000 description 1
- FWFUWXVFYKCSQA-UHFFFAOYSA-M sodium;2-methyl-2-(prop-2-enoylamino)propane-1-sulfonate Chemical compound [Na+].[O-]S(=O)(=O)CC(C)(C)NC(=O)C=C FWFUWXVFYKCSQA-UHFFFAOYSA-M 0.000 description 1
- 229940032094 squalane Drugs 0.000 description 1
- 239000000725 suspension Substances 0.000 description 1
- 230000035900 sweating Effects 0.000 description 1
- 230000001225 therapeutic effect Effects 0.000 description 1
- 238000002560 therapeutic procedure Methods 0.000 description 1
- 230000036572 transepidermal water loss Effects 0.000 description 1
- LADGBHLMCUINGV-UHFFFAOYSA-N tricaprin Chemical compound CCCCCCCCCC(=O)OCC(OC(=O)CCCCCCCCC)COC(=O)CCCCCCCCC LADGBHLMCUINGV-UHFFFAOYSA-N 0.000 description 1
- UFTFJSFQGQCHQW-UHFFFAOYSA-N triformin Chemical compound O=COCC(OC=O)COC=O UFTFJSFQGQCHQW-UHFFFAOYSA-N 0.000 description 1
- SCRSFLUHMDMRFP-UHFFFAOYSA-N trimethyl-(methyl-octyl-trimethylsilyloxysilyl)oxysilane Chemical compound CCCCCCCC[Si](C)(O[Si](C)(C)C)O[Si](C)(C)C SCRSFLUHMDMRFP-UHFFFAOYSA-N 0.000 description 1
- SMYKBXMWXCZOLU-UHFFFAOYSA-N tris-decyl benzene-1,2,4-tricarboxylate Chemical compound CCCCCCCCCCOC(=O)C1=CC=C(C(=O)OCCCCCCCCCC)C(C(=O)OCCCCCCCCCC)=C1 SMYKBXMWXCZOLU-UHFFFAOYSA-N 0.000 description 1
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Classifications
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- A61K8/49—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds
- A61K8/4973—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds with oxygen as the only hetero atom
- A61K8/498—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds with oxygen as the only hetero atom having 6-membered rings or their condensed derivatives, e.g. coumarin
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- A61K8/84—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds obtained by reactions otherwise than those involving only carbon-carbon unsaturated bonds
- A61K8/89—Polysiloxanes
- A61K8/891—Polysiloxanes saturated, e.g. dimethicone, phenyl trimethicone, C24-C28 methicone or stearyl dimethicone
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- A61K8/92—Oils, fats or waxes; Derivatives thereof, e.g. hydrogenation products thereof
- A61K8/922—Oils, fats or waxes; Derivatives thereof, e.g. hydrogenation products thereof of vegetable origin
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q17/00—Barrier preparations; Preparations brought into direct contact with the skin for affording protection against external influences, e.g. sunlight, X-rays or other harmful rays, corrosive materials, bacteria or insect stings
- A61Q17/005—Antimicrobial preparations
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- A—HUMAN NECESSITIES
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- A61Q19/10—Washing or bathing preparations
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- A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
- A61K2800/20—Chemical, physico-chemical or functional or structural properties of the composition as a whole
- A61K2800/30—Characterized by the absence of a particular group of ingredients
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- A61K2800/20—Chemical, physico-chemical or functional or structural properties of the composition as a whole
- A61K2800/30—Characterized by the absence of a particular group of ingredients
- A61K2800/33—Free of surfactant
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- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
- Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
- Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change
Definitions
- the invention relates to a new category of ecobiological cosmetic topical products comprising alcohol at a defined dose to be endowed with virucidal, bactericidal and yeasticidal activities and a lipid substrate at a defined dose to preserve and promote the lipid film of the skin, thus making it possible to maintain its properties in terms of its barrier effect and its hydration.
- This combination is particularly well tolerated, including during intensive use (repeated several times a day).
- the invention also relates to the use of this composition for disinfecting the skin and to a method of manufacturing said composition.
- the skin generally contains millions of different microorganisms (bacteria, viruses, yeasts, etc.) present at concentrations exceeding millions or even billions of colony forming units (CFU) per square centimeter (cm 2 ).
- bacteria bacteria, viruses, yeasts, etc.
- CFU colony forming units
- washing and / or disinfecting the skin, in particular the hands is recommended by healthcare professionals.
- hand cleaning is particularly recommended since it is one of the most effective actions to repeat to limit the risk of transmission and / or contamination.
- the hands are cleaned in particular with washing compositions, washing gels or else by friction with hydro-alcoholic solutions or gels.
- biocides are particularly aggressive for the skin and for the skin microbiome, that is to say the community of microorganisms that make up the skin flora. Biocides are therefore the cause of side effects such as intolerance, allergies or skin lesions which have been frequently noted by health professionals; their use is generally limited.
- the skin is the first protective barrier against external aggressions (pathogens, contamination, chemical attacks, etc.). Through its barrier function, the skin plays a protective role against external stress factors and also prevents the evaporation of water. Regularly attacked by these cleansing compositions, the skin can lose its natural defense and protection capacities over time. Repeated multi-daily washes have an undeniable effect on the skin ecosystem by eliminating the lipids which naturally preserve and protect the skin.
- the Applicant has developed a new category of innovative products making it possible, in a single product called an ecobiological lipoalcoholic topical formulation, to obtain the properties of several products without their respective drawbacks.
- This new category of innovative products makes it possible to ensure effective cleaning of the skin, for example effective disinfection of the hands, without having the drawbacks of the products of the prior art.
- the Applicant has developed formulations capable of providing unexpectedly three complementary properties: disinfection, hydration / protection of the skin barrier and very high tolerance.
- the invention relates to a topical lipoalcoholic composition, ecobiological disinfectant virucidal, where appropriate bactericidal and / or levuricidal, by friction and without rinsing, capable of regenerating the skin lipid barrier and perfectly well tolerated by the skin including during repeated daily intensive use, characterized in that it includes:
- Ci-Cs alcohol at least 65% w / w of a Ci-Cs alcohol
- composition of an oily phase comprising at least one component chosen from the list of the following components: vegetable oils, mineral oils, silicone oils, butters, esters, vegetable waxes, mineral waxes, silicone waxes , fatty acids, fatty alcohols with fatty chains greater than 10 carbons.
- the alcohol content must be greater than or equal to 65% by weight of the composition to ensure a virucidal, where appropriate bactericidal and optionally yeasticidal effect.
- the oily phase must be greater than or equal to 10% by weight of the composition to ensure true reconstruction of the lipid film, lower concentrations not making it possible to truly reconstruct the barrier effect of the skin destructured by the. alcohol.
- the Applicant has developed a composition which provides a virucidal effect, where appropriate bactericidal and optionally yeasticidal by friction, regenerating the surface hydrolipidic film, without major intolerance phenomena being observed.
- ecobiological composition denotes a composition which respects the biology of the skin, in particular the lipid or hydrolipid barrier, and is well tolerated by the skin.
- An ecobiological composition according to the invention therefore makes it possible to respect the barrier property of the skin consisting of:
- PIE insensible water loss
- the quality of the barrier function of the skin can be assessed by an in vivo measurement of the insensitive water loss (IEP). Unlike sweating, the insensible loss of water is not visible to the naked eye.
- the quantity of water crossing the stratum corneum (outermost layer of the skin) by this route is evaluated between 300 and 400 ml / d under normal conditions, but can be multiplied by 10 or 20 in the event of irritation or breaking of the barrier effect.
- the IEP is measured using, for example, the TM300 Tewameter (Monaderm), and the results are expressed as a% reduction in the IEP (improvement of the barrier effect) compared to the mean values of the IEP measured after application of a hydroalcoholic solution. commercial standard.
- a PIE greater than or equal to 50% indicates an improvement in the barrier effect.
- the composition according to the invention exhibits a reduction in the IEP of greater than or equal to 50% (Tewameter TM300 (Monaderm) of that measured with a standard commercial hydroalcoholic solution.
- an ecobiological composition provides a tolerance effect with respect to the skin and ensures the prevention / regeneration of the skin lipid barrier.
- lipoalcoholic composition denotes a composition comprising an alcohol phase, an oily phase and optionally water.
- the water concentration is lower than the concentration of oily components and the concentration of alcohol (water ⁇ oily phase and water ⁇ alcohol phase).
- the water represents less than 20% by total weight of the composition according to the invention, advantageously less than 15%, preferably less than 10%.
- composition according to the invention provides a virucidal and / or antimicrobial effect (that is to say a bactericidal and / or yeasticidal effect), advantageously a virucidal, bactericidal and yeasticidal effect, while allowing the preservation and / or the restoration.
- a virucidal and / or antimicrobial effect that is to say a bactericidal and / or yeasticidal effect
- a virucidal, bactericidal and yeasticidal effect advantageously a virucidal, bactericidal and yeasticidal effect, while allowing the preservation and / or the restoration.
- intrinsic properties of the skin that is to say by providing a barrier and tolerance effect.
- the Ci-Cs alcohol is chosen from the list of the following components: ethanol, isopropanol, propanol, butanol, pentanol, hexanol, heptanol, octanol, each being in linear or branched form and their mixtures.
- Ci-Cs alcohol is chosen from the list of the following components: ethanol, isopropanol and their mixture.
- the ecobiological lipoalcoholic composition according to the invention comprises between 65% and 80% w / w of a C1-Cs alcohol, advantageously between 70% and 80% w / w.
- the oily phase of the composition according to the invention comprises at least one vegetable oil chosen from the list of the following components (INCI name): vegetable squalane, hexyl laurate, octododecanol, dibutyl adipate, coco-caprylate / caprate, dicaprylyl carbonate, decyl oleate, dicaprylyl ether, cocoglycerides, 00-18 triglyceride, caprylic / capric triglyceride, prunus oil and prunus kernel oil, ribes seed oil, pongamia seed oil, corylus seed oil, brassica seed oil, butyrospermum helianthus annuus seed oil, olea europaea fruit oil, coco nucifera oil, simmondsia chinensis seed oil, canola oil, cyperus esculentus root oil, limnanthes seed oil, mangifera seed butter
- the oily phase of the composition according to the invention comprises at least one fatty substance chosen from the list of the following components (INCI name): isohexadecane, isododecane, propylheptyl caprylate, cetearyl isononanoate, ethylhexyl hydrostearate, ethylhexyl palmitate , diisopropyl sebacate, butyloctyl salicylate, propylene glycol dicaprylate / dicaprate, tridecyl trimellitate, C12-C15 alkyl benzoate, hydrogenated polydecene, caprylyl methicone, triethylhexanoin, paraffinum liquidum / minerallyicone oil, dipethlenethritylhexyprylate / minerallyicone oil, dipetherythritylhexacaobutylate / minerallyicone oil, dipetherythritylhe
- the oily phase of the composition according to the invention comprises at least one polymer chosen from the list of the following components (INCI name): hydroxypropylcellulose, PVP, Vinyl alcohol / butyl maleate / isobornyl acrylate copolymer, methyl hydroxypropylcellulose, hydroxypropylguar, polyacrylate crosspolymer-6, ammonium acryloyldimethyltaurate / VP copolymer, carbomer, acrylate copolymer, hydroxyethylacrylate / sodium acryloyldimethyl taurate copolymer, acrylamide / sodiumacryloyldimethyl taurate, vinyl acrylate / C10-C30 alkyl crosspolymate and acrylate / crosspolymate mixtures thereof.
- ICI name hydroxypropylcellulose, PVP, Vinyl alcohol / butyl maleate / isobornyl acrylate copolymer, methyl hydroxypropylcellulose, hydroxypropylgu
- the composition according to the invention advantageously the oily phase, comprises at least one natural or chemical molecule having specific properties in virology such as glycerrhizin, baicalin, quercetin, theaflavin, or their respective derivatives. .
- the oily phase of the composition according to the invention can comprise all the combinations of components mentioned above.
- the oily phase according to the invention can comprise at least one vegetable oil and / or at least one fatty substance and / or at least one polymer and / or at least one purified vegetable substance having specific properties in virology. .
- the eco-organic lipoalcoholic composition according to the invention comprises at least 12% by total weight of the composition of the oily phase, advantageously at least 20%.
- composition according to the invention when the composition according to the invention comprises at least 80% w / w of Ci-Cs alcohol, it comprises at least 11% by total weight of the composition of the oily phase.
- composition according to the invention when the composition according to the invention comprises between 75% and strictly less than 80% w / w of Ci-Cs alcohol, it comprises between 10% and 30% by total weight of the composition of the oily phase, advantageously between 20% and 30%.
- composition according to the invention further comprises:
- At least one lipophilic component advantageously a lipophilic component chosen from natural lipophilic constituents of skin tissue, and / or lipophilic biomimetic constituents; and or
- hydrophilic component advantageously a hydrophilic component chosen from natural hydrophilic constituents of skin tissue, and / or hydrophilic biomimetic constituents
- biomimetic component denotes a component which has a structure close to a natural component of the skin and makes it possible to activate the same effectors as said. compound or product of the skin; or which mimics the action of a component naturally present in the skin, in order to produce the same effects.
- the composition according to the invention has a pH of between 5 and 7.5; advantageously between 5.5 and 6.8.
- the ecobiological lipoalcoholic composition according to the invention is a two-phase composition in the form of two immiscible phases each present in continuous form and free of surfactant.
- the ecobiological lipoalcoholic composition according to the invention is in the form of a gel and comprises a gelling agent representing, advantageously, between 0.1% and 5% by total weight of the composition.
- the gelling agent is chosen from the list of the following components (INCI name): Sodium Hyaluronate, Xanthan gum, Cellulose Gum, Sodium Acrylates Copolymer, Algin,
- the ecobiological lipoalcoholic composition according to the invention is in the form of an emulsion.
- the ecobiological lipoalcoholic composition according to the invention does not contain any of the following components:
- essential oils advantageously the essential oils of eucalyptus, tea tree, bay leaf, rosemary, spearmint, pepper, rose, sage, peppermint, camphor tree, mukurossi and soapberry; and
- foaming surfactant type cleaning agents advantageously ammonium lauryl sulfoccinate and lauramidopropyl betaine
- composition according to the invention is incorporated into a wipe or a compress.
- the ecobiological lipoalcoholic composition according to the invention is a composition according to the invention:
- microbiocidal i.e. bactericidal and / or yeasticidal
- virucidal effects i.e. bactericidal and / or yeasticidal
- composition according to the invention is used for disinfecting the skin by eliminating viruses, where appropriate bacteria and optionally yeasts.
- the term “skin” denotes any keratinous substrate on the external surface of the body, including, but not limited to, the hands, the face, the armpits, the hair and the scalp.
- composition according to the invention is used for disinfecting the hands.
- composition according to the invention in that it involves removing bacteria, viruses and yeasts from healthy skin, which is not necessarily prophylactic. since, even in the presence of potentially pathogenic bacteria, viruses and yeasts on their skin, an individual is not necessarily going to develop a pathology.
- the invention relates to a non-therapeutic method of disinfecting the hands consisting of:
- compositions to the hands by friction with a contact time of at least 30 seconds, advantageously at least 60 seconds.
- the invention relates to a process for manufacturing the composition as described above, consisting in: a) mixing the oily components to produce the oily phase; b) adding the Ci-Cs alcohol, preferably ethanol, advantageously absolute ethanol, to the oily phase prepared in step a).
- step a) further comprises the addition:
- step a) further comprises the addition:
- a gelling agent advantageously representing between 0.1% and 5% by total weight of the composition.
- the gelling agent is chosen from the list of the following components (INCI name): Sodium Hyaluronate, Xanthan gum, Cellulose Gum, Sodium Acrylates Copolymer, Algin, Acrylates / Vinyl Isodecanoate Crosspolymer, Sodium Acrylate / Sodium Acryloyldimethyl Taurate Copolymer, Acrylates / C10- Alkyl Acrylate Crosspolymer, Disteardimonium Hectorite, Hydroxyethyl Acrylate / Sodium Acryloyldimethyl Taurate Copolymer, Microcrystalline Cellulose, Sclerotium Gum and mixtures thereof.
- the manufacturing process according to the invention has the advantages of being particularly simple, inexpensive, and usable on an industrial scale.
- Example 1 Two-phase cosmetic compositions according to the invention
- the formulas are tested according to standard NF EN 13727 according to the specific protocol for cleaning products / hygienic friction. Briefly, the formulas to be evaluated are brought into contact with various microorganisms in suspensions after a contact time of 30 and 60 seconds at 20 ° C., at a test concentration of 50 and 80%.
- the minimum test strains evaluated are: Pseudomonas aeruginosa, Staphylococcus aureus, Enterococcus hirae, Echerichia coli K12, Candida albicans DSM1386, Poliovirus 1 sabine strain, Adenovirus type 5, Murine norovirus S99, vaccinia virus strain Ankara ATCC VR-1508.
- the test is validated and noted “+”, if the microorganisms are not all destroyed, the result is noted “+/-”, if the microorganisms are not destroyed under the conditions of the test, the result is noted "-”.
- IWP insensitive water loss
- Tolerance effect During the PIE study above, the evaluation of the skin quality (presence of inflammation, irritation, redness, injuries) of the hands of the volunteers who continued to use the products tested on a daily basis is carried out. by a dermatologist. If redness or intolerance is observed on more than 30% of the hands evaluated, the result is noted “-”, if they are observed on more than 10% of the hands evaluated, the result is noted “+/-”, if they are observed on less than 10% of the hands evaluated, the result is noted "-”.
- Example 1 in particular Examples IB to 1E, are therefore capable of exerting all the expected effects, unlike the hydroalcoholic solutions currently marketed.
- the virucidal effect is obtained from 65% alcohol.
- the barrier effect is obtained with more than 10% lipids. Tolerance varies with the level of lipids provided by the formulation.
- Example 2 in particular Examples 2B to 2E, are therefore capable of exerting all the expected effects, unlike the hydroalcoholic solutions currently marketed.
- the measurements of the bactericidal, virucidal, yeasticidal, barrier and tolerance effects are carried out by following the protocols described in Example 1 of the invention.
- Example 3 in particular Examples 3B to 3E, are therefore capable of exerting all the expected effects, unlike the hydroalcoholic solutions currently marketed.
- the measurements of the bactericidal, virucidal, yeasticidal, barrier and tolerance effects are carried out by following the protocols described in Example 1 of the invention.
- Example 4 in particular Examples 4B to 4F are therefore capable of exerting all the expected effects, unlike the hydroalcoholic solutions currently marketed.
- Example 5 Cosmetic compositions of lipoalcoholic gel type
- the measurements of the bactericidal, virucidal, yeasticidal, barrier and tolerance effects are carried out by following the protocols described in Example 1 of the invention.
- Example 5 The formulations of Example 5 are therefore capable of exerting all the expected effects, unlike the hydroalcoholic solutions commonly marketed.
- Example 6 Cosmetic compositions of lipoalcoholic emulsion type
- the measurements of the bactericidal, virucidal, yeasticidal, barrier and tolerance effects are carried out by following the protocols described in Example 1 of the invention.
- Example 6 The formulations of Example 6 are therefore capable of exerting all the expected effects, unlike the hydroalcoholic solutions currently marketed.
- Example 7 Comparative cosmetic compositions according to the invention The ingredients are identified according to the INCI nomenclature and the percentages are given by weight / weight in tables 13 and 14. T corresponds to a formulation of the composition according to the invention and the formulations 7A to 7N are formulations of the prior art.
- the measurements of the bactericidal, virucidal, yeasticidal, barrier and tolerance effects are carried out by following the protocols described in Example 1 of the invention.
- Example 7 (7A to 7N) are therefore not capable of exerting all the expected effects of the invention, unlike the control T which corresponds to a formulation of the composition according to invention.
- Strong to very strong intolerance problems have been demonstrated after only a few days of multiple daily applications, in particular with the use of essential oils, perfumes, pH adjusters, bactericides, and more. more surprising with emulsifiers derived from silicone and foaming surfactants.
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Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| FR2005970A FR3111073B1 (fr) | 2020-06-08 | 2020-06-08 | Composition lipoalcoolique ecobiologique |
| PCT/EP2020/074563 WO2021249661A1 (fr) | 2020-06-08 | 2020-09-03 | Composition lipoalcoolique ecobiologique |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| EP4161475A1 true EP4161475A1 (de) | 2023-04-12 |
Family
ID=72355989
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| EP20767531.5A Pending EP4161475A1 (de) | 2020-06-08 | 2020-09-03 | Ökobiologische fett-alkohol-zusammensetzung |
Country Status (10)
| Country | Link |
|---|---|
| US (1) | US20240285490A1 (de) |
| EP (1) | EP4161475A1 (de) |
| JP (1) | JP2023529899A (de) |
| KR (1) | KR20230028722A (de) |
| CN (1) | CN115697283A (de) |
| BR (1) | BR112022025027A2 (de) |
| CA (1) | CA3180754A1 (de) |
| FR (1) | FR3111073B1 (de) |
| MX (1) | MX2022015619A (de) |
| WO (1) | WO2021249661A1 (de) |
Family Cites Families (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS5910511A (ja) * | 1982-07-07 | 1984-01-20 | Eisai Co Ltd | 脂溶性物質含有水性液 |
| US8840911B2 (en) * | 2008-03-07 | 2014-09-23 | Kimberly-Clark Worldwide, Inc. | Moisturizing hand sanitizer |
| US9439841B2 (en) * | 2013-06-06 | 2016-09-13 | Ecolab Usa Inc. | Alcohol based sanitizer with improved dermal compatibility and feel |
| CN105362103A (zh) * | 2015-12-19 | 2016-03-02 | 南京巨鲨显示科技有限公司 | 一种速干型手消毒乳液 |
| CA3027872A1 (en) * | 2016-06-20 | 2017-12-28 | Essity Hygiene And Health Aktiebolag | Hand sanitizing composition |
-
2020
- 2020-06-08 FR FR2005970A patent/FR3111073B1/fr active Active
- 2020-09-03 JP JP2022575780A patent/JP2023529899A/ja active Pending
- 2020-09-03 CN CN202080101835.XA patent/CN115697283A/zh active Pending
- 2020-09-03 CA CA3180754A patent/CA3180754A1/fr active Pending
- 2020-09-03 WO PCT/EP2020/074563 patent/WO2021249661A1/fr unknown
- 2020-09-03 EP EP20767531.5A patent/EP4161475A1/de active Pending
- 2020-09-03 US US18/000,863 patent/US20240285490A1/en active Pending
- 2020-09-03 MX MX2022015619A patent/MX2022015619A/es unknown
- 2020-09-03 KR KR1020227043220A patent/KR20230028722A/ko unknown
- 2020-09-03 BR BR112022025027A patent/BR112022025027A2/pt unknown
Also Published As
| Publication number | Publication date |
|---|---|
| FR3111073B1 (fr) | 2023-05-05 |
| WO2021249661A1 (fr) | 2021-12-16 |
| MX2022015619A (es) | 2023-03-21 |
| CN115697283A (zh) | 2023-02-03 |
| FR3111073A1 (fr) | 2021-12-10 |
| BR112022025027A2 (pt) | 2023-02-14 |
| KR20230028722A (ko) | 2023-03-02 |
| JP2023529899A (ja) | 2023-07-12 |
| US20240285490A1 (en) | 2024-08-29 |
| CA3180754A1 (fr) | 2021-12-16 |
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