EP4152300A1 - Système comprenant une seringue et une étiquette adhésive - Google Patents

Système comprenant une seringue et une étiquette adhésive Download PDF

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Publication number
EP4152300A1
EP4152300A1 EP22199776.0A EP22199776A EP4152300A1 EP 4152300 A1 EP4152300 A1 EP 4152300A1 EP 22199776 A EP22199776 A EP 22199776A EP 4152300 A1 EP4152300 A1 EP 4152300A1
Authority
EP
European Patent Office
Prior art keywords
label
adhesive label
syringe
adhesive
closure
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
EP22199776.0A
Other languages
German (de)
English (en)
Inventor
Nadine OETZEL
Stefan Krauss
Kerstin KLINGEN
Andreas Hofenauer
Tanja MESSMER
Robert Unglert
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Schreiner Group GmbH and Co KG
Original Assignee
Schreiner Group GmbH and Co KG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Schreiner Group GmbH and Co KG filed Critical Schreiner Group GmbH and Co KG
Publication of EP4152300A1 publication Critical patent/EP4152300A1/fr
Pending legal-status Critical Current

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Classifications

    • G—PHYSICS
    • G09—EDUCATION; CRYPTOGRAPHY; DISPLAY; ADVERTISING; SEALS
    • G09F—DISPLAYING; ADVERTISING; SIGNS; LABELS OR NAME-PLATES; SEALS
    • G09F3/00—Labels, tag tickets, or similar identification or indication means; Seals; Postage or like stamps
    • G09F3/02—Forms or constructions
    • G09F3/0288—Labels or tickets consisting of more than one part, e.g. with address of sender or other reference on separate section to main label; Multi-copy labels
    • G—PHYSICS
    • G09—EDUCATION; CRYPTOGRAPHY; DISPLAY; ADVERTISING; SEALS
    • G09F—DISPLAYING; ADVERTISING; SIGNS; LABELS OR NAME-PLATES; SEALS
    • G09F3/00—Labels, tag tickets, or similar identification or indication means; Seals; Postage or like stamps
    • G09F3/02—Forms or constructions
    • G09F3/0291—Labels or tickets undergoing a change under particular conditions, e.g. heat, radiation, passage of time
    • G09F3/0292—Labels or tickets undergoing a change under particular conditions, e.g. heat, radiation, passage of time tamper indicating labels
    • G—PHYSICS
    • G09—EDUCATION; CRYPTOGRAPHY; DISPLAY; ADVERTISING; SEALS
    • G09F—DISPLAYING; ADVERTISING; SIGNS; LABELS OR NAME-PLATES; SEALS
    • G09F3/00—Labels, tag tickets, or similar identification or indication means; Seals; Postage or like stamps
    • G09F3/02—Forms or constructions
    • G09F3/03—Forms or constructions of security seals
    • G09F3/0305—Forms or constructions of security seals characterised by the type of seal used
    • G09F3/0341—Forms or constructions of security seals characterised by the type of seal used having label sealing means
    • G—PHYSICS
    • G09—EDUCATION; CRYPTOGRAPHY; DISPLAY; ADVERTISING; SEALS
    • G09F—DISPLAYING; ADVERTISING; SIGNS; LABELS OR NAME-PLATES; SEALS
    • G09F3/00—Labels, tag tickets, or similar identification or indication means; Seals; Postage or like stamps
    • G09F3/08—Fastening or securing by means not forming part of the material of the label itself
    • G09F3/10—Fastening or securing by means not forming part of the material of the label itself by an adhesive layer
    • G—PHYSICS
    • G09—EDUCATION; CRYPTOGRAPHY; DISPLAY; ADVERTISING; SEALS
    • G09F—DISPLAYING; ADVERTISING; SIGNS; LABELS OR NAME-PLATES; SEALS
    • G09F3/00—Labels, tag tickets, or similar identification or indication means; Seals; Postage or like stamps
    • G09F3/02—Forms or constructions
    • G09F2003/0264—Shapes or borders
    • G09F2003/0269—Shapes or borders perforated
    • G—PHYSICS
    • G09—EDUCATION; CRYPTOGRAPHY; DISPLAY; ADVERTISING; SEALS
    • G09F—DISPLAYING; ADVERTISING; SIGNS; LABELS OR NAME-PLATES; SEALS
    • G09F3/00—Labels, tag tickets, or similar identification or indication means; Seals; Postage or like stamps
    • G09F3/02—Forms or constructions
    • G09F2003/0272—Labels for containers
    • G—PHYSICS
    • G09—EDUCATION; CRYPTOGRAPHY; DISPLAY; ADVERTISING; SEALS
    • G09F—DISPLAYING; ADVERTISING; SIGNS; LABELS OR NAME-PLATES; SEALS
    • G09F3/00—Labels, tag tickets, or similar identification or indication means; Seals; Postage or like stamps
    • G09F3/02—Forms or constructions
    • G09F2003/0272—Labels for containers
    • G09F2003/0273—Labels for bottles, flasks

Definitions

  • the present invention relates to a system with a syringe and an adhesive label, which can contribute to a reliable coupling of syringe components as well as to secure protection against manipulation for the syringe in a simple and cost-effective manner.
  • a label can be used in particular for marking or proof of origin in relation to an object to be marked.
  • labels are used when it is necessary to identify the contents of a container. This applies in particular to containers in the pharmaceutical and medical sectors, the contents of which are to be protected against manipulation.
  • an adhesive label for a multi-part vessel with a threaded element and a vessel body has a first, flat label section which is designed to be attached to the threaded element of the vessel.
  • the adhesive label also has a second label section, which adjoins the first label section and has a comb-like structure with a plurality of strip-shaped fixing elements.
  • the second label section with the fixing elements is designed to be attached to the vessel body of the vessel, so that the adhesive label couples the threaded element to the vessel body and counteracts a movement of the threaded element relative to the vessel body.
  • a threaded element can be fixed reliably and cost-effectively to the associated body and it can also contribute to reliable protection against manipulation.
  • the adhesive label is particularly suitable for packaging or containers in the pharmaceutical sector, such as syringes, injection bottles or vials, which usually include a threaded element that is placed or pushed onto the associated container body.
  • the threaded element includes, for example, a section with an internal thread, which forms a kind of thread head that borders on a section that allows it to be placed or pushed onto the vessel body.
  • the threaded member is threaded over its entire outer surface.
  • the threaded section is coupled to a closure which forms a cap of the vessel and securely closes it.
  • the threaded element which is usually formed from a plastic part and provided with a threaded section, is attached to the front of the glass syringe.
  • a plastic threaded element is fastened by mechanical interlocking or gluing to the glass syringe.
  • attachment of the threaded element to syringes is often insufficient.
  • screwing in a syringe needle it can happen that the mechanical or adhesive coupling does not withstand and the threaded element turns with it, especially if the user does not hold the threaded element when screwing in the syringe needle. It can also happen that when using highly viscous formulations, the syringe needle flakes off together with the threaded element.
  • the adhesive label described enables the threaded element to be fixed, in particular in the form of a Luer lock thread in syringes, so that the Luer lock thread is attached sufficiently firmly to the syringe in the application.
  • the adhesive label in particular in coordination with the threaded element, can be designed in such a way that a first-opening indication is provided.
  • the container can be enclosed as if by a second skin, so that the adhesive label also provides a Protective function, such as protection against UV radiation, for a drug located in the vessel.
  • the strip-shaped fixing elements each have a predetermined alignment transversely to the first label section and each enclose a predetermined angle with an adjoining edge of the first label section.
  • one or more of the fixing elements can each enclose an angle of less than 90° or greater than 90° with the adjoining edge of the first label section. Based on a state applied to the vessel, the fixing elements according to such an embodiment enclose the circumference of the vessel body in a spiral manner and reliably counteract an undesired co-rotation of the threaded element when the vessel is opened.
  • some strip-shaped fixing elements enclose an angle of less than 90° with the adjoining edge of the first label section, and further strip-shaped fixing elements enclose an angle greater than 90°.
  • the adhesive label has a comb-like structure with sections that face each other. Based on a state applied to the vessel, the respective fixing elements enclose the circumference of the vessel body in a spiral manner and come to rest on one another in sections.
  • the differently aligned sections of the comb-like structure are preferably formed on the outside at opposite ends of the adhesive label.
  • the adhesive label and the fixing elements are designed so wide or long that an wrap-around label is realized with regard to the container that is to be provided with the adhesive label.
  • the first label section around the threaded element and the second label section around the Vessel body wrapped so that the fixing elements located on the outside intersect and cover sections. In this way, a particularly stable hold of the adhesive label on the container can be set up and a relative movement of the threaded element relative to the container body is reliably counteracted.
  • the first label section is also designed to extend into the area of a closure of the vessel and in particular to be attached to it, so that the adhesive label also couples the closure to the vessel body.
  • the adhesive label can surround the closure more or less without contact and form a kind of sleeve around it or alternatively be connected to it, for example glued.
  • the first label section of the adhesive label is in particular adhesively connected to the threaded element and can also enclose the closure of the vessel in the manner of a sleeve without being adhesively coupled to it or to it.
  • the first label section can thus enclose the closure in relation to its longitudinal axis in a contact-free or non-adhesive manner.
  • An upper part of the first label section then forms a label sleeve that is open at the top with respect to the longitudinal axis.
  • the first label section is then pressed against an outer surface of the closure and separated from a lower part of the first label section and from the second label section by pulling and/or turning and removed from the vessel body together with the closure of the vessel.
  • top and bottom refer to an operational arrangement or use of the adhesive label and the container. This also applies to designations such as "head” and "body”, with the head usually being at the top and the body usually being at the bottom.
  • the closure of the vessel forms, for example, a head of an injection vial or a syringe as an upper part, and comprises, for example, a cap, a lid or a primary closure or a primary cap, which is removed to open the vessel.
  • the vessel body then forms, for example as the lower part, a container of the injection bottle or the syringe for receiving and storing a predetermined content.
  • the first label section of the adhesive label is assigned to the upper component of the vessel and thus to the threaded element and/or the closure and can therefore also be referred to as the upper label section.
  • the second label section of the adhesive label is associated with the lower component of the vessel and remains on the vessel body or the container of the vessel after opening and can therefore also be referred to as the lower label section.
  • a reverse orientation and use of the adhesive label is also possible, in which the fixing elements are attached to the threaded element and this is fixed with respect to relative movements by means of the first label section, which is then placed on the vessel body.
  • the described embodiments of the adhesive label in which the upper label section extends to the closure of the vessel, are particularly suitable for providing proof of opening in addition to the fixed hold of the threaded element and for forming protection against tampering.
  • the closure is removed from the threaded element and, for example, pulled off or torn off from the remainder together with a partial element of the first label section.
  • the part of the adhesive label remaining on the body of the container indicates that the container has been opened.
  • the first label section is preferably formed in such a way that there is only a narrow gap or space between the closure and the surrounding first label section. Manipulation or an attempt to open the label by reaching into the narrow gap from above will tear or crumple the first label section, so that such an operation would leave visible traces.
  • the adhesive label can in particular be designed as a label that can be stuck on, so that it partially or completely covers the threaded element and the vessel body in relation to a circumference.
  • the adhesive label can be designed in particular in such a way that the first and/or the second label section is designed in coordination with a circumference of the threaded element and/or the closure and/or the vessel body of the vessel that is to be provided with the adhesive label, and a predetermined length having.
  • the adhesive label can thus be designed partially or completely as an all-round or over-all-round label.
  • the length of the first label portion is designed as an wraparound portion so that when applied, it completely encloses a circumference of the threaded element and partially covers or overlaps itself, while the second label portion covers only part of the outer surface of the vessel body and does not wrap around it.
  • the length of the second label section is designed as an all-round section, so that when it is applied it completely surrounds the circumference of the container body.
  • the first label section is designed to match a surface structure of the threaded element and/or the closure of the vessel to which the adhesive label is to be applied and has a predetermined punched-out area or recess.
  • a recess can be designed in particular as a punched-out recess complementary to an elevation or one or more projecting areas.
  • nubs or a ring-shaped elevation are provided on the threaded element and/or the closure of the vessel, so that the adhesive label has circular or elongated or ring-shaped recesses adapted to the respective surface structure, which correspond to the surface structure.
  • the adhesive label has an elongated recess in coordination with such an elevation, which forms a substantially ring-shaped recess when applied to the vessel.
  • the adhesive label has at least one holding web, preferably two spaced-apart holding webs or a plurality of holding webs arranged equidistantly, so that the lower, second label section is connected to the upper, first label section.
  • the first label section is designed to match a surface structure of the threaded element and/or the closure and has at least a partial multi-layer structure.
  • the second label section with the comb-like structure can also be adapted to a surface structure and/or a circumference of the vessel body of the vessel to which the adhesive label is to be attached. be formed and have at least a partial multi-layer structure.
  • the adhesive label with several layers can, for example, compensate for different radii or diameters of a cylindrical vessel to which the adhesive label is to be attached. Small differences in diameter between the threaded element and the container body can be overcome with just one layer thanks to the comb structure of the second label section.
  • multiple layers can contribute to proof of opening, so that, for example, a section of an upper layer is cut off in a predetermined manner when the marked vessel is opened and an area of a lower layer underneath is specifically exposed in order to clearly and visibly mark an opening.
  • the exposed section of such a lower layer is marked in color, for example, or has a predetermined lettering such as "used", "open” or "opened".
  • the adhesive label preferably has an adhesive layer which is arranged on an underside of the first and/or the second label section, so that the adhesive label can be arranged on the vessel by means of gluing. In this way, the adhesive label can be applied to the container provided for it in a cost-effective, simple and reliable manner.
  • the adhesive layer can completely or partially cover the underside of the adhesive label.
  • the adhesive layer can be designed in accordance with a material or a surface structure of the threaded element, the closure and/or the vessel.
  • An adhesive of the adhesive layer is specifically selected, for example taking into account a surface roughness of the threaded element, in order to set up a stable hold of the adhesive label on the vessel and a reliable fixation of the threaded element.
  • the adhesive label in particular the first label section, has a severing area with a severing element, so that when the container applied with the adhesive label is opened, the adhesive label can be severed in a predetermined manner along the severing area, so that at least a first partial element of the first label section together with the Closure of the vessel is removable from a second partial element of the first label section and the vessel body of the vessel.
  • the adhesive label can have an adhesive-free surface in the severing area, so that when the applied vessel, a simple and low-resistance severing of the adhesive label along the severing element can be carried out.
  • the severing element can in particular be designed as a perforation and enable predetermined tearing.
  • the adhesive label can have a foil or a foil element in the severing area that has a relatively low tear resistance, so that the foil element and thus the adhesive label can easily be torn and severed.
  • a film element is designed as an acetate film, for example, and does not require a separate perforation or other weakening structure in order to enable easy severing.
  • the adhesive label also has, for example, an adhesive surface in an upper area of the first label section that faces away from the second label section.
  • the adhesive area of the first label section is then glued to a closure of the container and can be removed from the remaining adhesive label and the threaded element or container body when the container is opened with the closure. Thus, no separate segment is left as waste for disposal.
  • the adhesive label extends to a closure of the vessel and the closure or the adhesive label itself comprises a severing area
  • the adhesive label preferably has an area free of adhesive in the severing area. This makes it easier to sever the adhesive label and remove the detachable part of the first label section. The amount of force required to separate the adhesive label is reduced in comparison to a completely adhesive adhesive label, and the opening dynamics of the container applied with the adhesive label are improved.
  • the respective severing area can be formed in an area of the adhesive label, which is assigned to a transition between the closure and the threaded element or the threaded element and the container body in an applied state on the container, in particular in coordination with the container to be applied.
  • the severing area is located, for example, in a lower end area of the closure. A sufficiently strong turning and/or pulling on the closure of the vessel then leads to the adhesive label being severed.
  • the severing area can also be arranged in other areas which allow the adhesive label to be separated when the container is opened.
  • the severing area can be set up, for example, well below the area of the lower end of the closure, so that an upper or outwardly directed layer of the adhesive label tears in a predetermined manner due to an acting tensile and/or twisting force.
  • a severing element for example in the form of a perforation or a tear-off strip, can be provided in the severing area, which allows controlled severing of the adhesive label.
  • the adhesive label can be designed with specified surface properties, for example in the area of the first label section, which allow the container to be opened more easily and the adhesive label to be severed by the user.
  • Such useful surface properties can be realized, for example, with anti-slip coatings, using printed tactile elements or surface microstructuring, which enable the first label section to be gripped more securely.
  • the adhesive label comprises an opening verification element which is integrated in the first label section or coupled to it and which is designed to indicate removal of at least a first partial element of the first label section from the second label section and the vessel body of the vessel.
  • the opening detection element can in particular interact with the previously described severing element in the form of a perforation and clearly indicate a predetermined tearing of the adhesive label.
  • the opening verification element can be realized in the form of a colored surface or a deposited lettering, which is exposed when the container provided with the adhesive label is opened.
  • the adhesive label can include an electronic proof-of-opening element in the form of an RFID transponder, which is coupled to the first label section and which includes a chip and an antenna structure, which is connected to the chip by means of a conductor track.
  • the conductor track extends in particular into the severing area and covers it at least in sections severing element.
  • the adhesive label described helps to prevent the threaded element from turning when the vessel is opened or a syringe needle is attached.
  • the adhesive label can contribute to protection against tampering with respect to the vessel, whereby, for example, the integrity of a medication packaging can be guaranteed or such can be indicated.
  • the adhesive label can indicate an unconscious or unauthorized reuse of the correspondingly labeled container after it has been used. The possibility of tampering with the vessel is thus also counteracted by means of the adhesive label.
  • a further aspect includes the use of an embodiment of the described adhesive label for a vessel that can be divided into several parts for fixing a threaded element on a vessel body of the vessel.
  • a system comprises a multi-part vessel with a threaded element and a vessel body and an adhesive label which is applied to the vessel such that a first label section of the adhesive label is attached to the threaded element and a second label section of the adhesive label is attached to the vessel body , so that the adhesive label couples the threaded element to the vessel body and counteracts movement of the threaded element relative to the vessel body.
  • the adhesive label can be in the form of a full-surface label which is connected to the threaded element and to the vessel body in order to fix it.
  • the adhesive label of the system is preferably designed according to one of the configurations described above.
  • the first, flat label section is attached to the threaded element of the vessel and the strip-shaped fixing elements of the comb-like structure of the second label section are attached to the body of the vessel.
  • the system may further comprise a closure which is coupled to the vessel such that the threaded element is arranged between the vessel body and the closure, in which case the first label portion then extends in particular up to the closure or onto the closure.
  • the adhesive label and the threaded element and/or the closure and/or the container body are designed to be coordinated with one another. This takes into account, among other things, geometries, surface structures and materials of the interacting components.
  • the system has an opening detection element which is coupled to the threaded element and/or the closure and is designed to indicate removal of the closure from the vessel body.
  • an opening detection element of the container can be designed as an alternative or in addition to the previously described opening detection element of the adhesive label.
  • the closure is connected to the threaded element by means of connecting webs, which break open when the vessel is opened and thus provide visible evidence that an opening has taken place.
  • a method for attaching an adhesive label to a multi-part vessel with a threaded element and a vessel body comprises providing the vessel with the threaded element and the vessel body and providing the adhesive label which has a first label section and a second label section adjoining the first label section having.
  • the method further includes attaching the adhesive label to the vessel in such a way that the first label section is attached to the threaded element of the vessel and the second label section is attached to the vessel body of the vessel such that the adhesive label Threaded member couples to the vessel body and counteracts movement of the threaded member relative to the vessel body.
  • the adhesive label is designed in particular in the form of one of the configurations described above, so that the attachment of the adhesive label includes fastening the fixing elements of the comb-like structure to the vessel body of the vessel.
  • the fixing elements are in particular spirally wound around the container body and attached to it in such a way that they form an all-round label based on a circumference of the container body and at least one fixing element partially covers another fixing element.
  • the adhesive label is attached to the vessel in a targeted manner in order to set up a secure and reliable hold for the threaded element and to secure or fix it against undesired twisting relative to the vessel body. Due to the fact that the method relates in particular to an application or attachment of an embodiment of the described adhesive label, the described properties and features of the adhesive label are also disclosed for the method and vice versa. In particular, the described adhesive label also enables a threaded element to be subsequently fixed relative to a threaded body, for example of prefilled syringes.
  • the adhesive label can be easily and inexpensively attached to the vessel and does not require the application of heat, for example, as is the case with a shrink film, which is placed around elements to fasten them and shrunk by applying heat.
  • a shrink film which is placed around elements to fasten them and shrunk by applying heat.
  • there is also a temperature effect on the contents of the container and an associated process section is also required in a packaging line.
  • the adhesive label described does not require the action of temperature and can be provided in the form of a film with pressure-sensitive adhesive which can be applied to the vessel in a simple and reliable manner. A use of shrink films can therefore be saved.
  • the adhesive label described is explained again largely using the example of a vessel of a two-part syringe, which in particular is designed as a glass syringe or Plastic syringe can be realized with an adapting Luer lock thread.
  • the properties and features can also be transferred in relation to other multi-part vessels which have a threaded element which is coupled to an associated vessel body as a separate component.
  • the adhesive label has a special label structure in which the comb-like structure of the second label section is used on the one hand to bridge the different circumferences of the Luer lock thread and the syringe body and on the other hand to reliably absorb force when rotary forces occur.
  • the adhesive label enables simultaneous detection of the syringe casing and the outside of the Luer lock thread and, in various embodiments, also detection of the vascular occlusion if the adhesive label is also intended to indicate first opening, and in this respect can be designed with a relatively high adhesive strength.
  • the outside of the Luer lock thread and optionally also that of the vessel closure are preferably designed in such a way that they are flush with a lateral surface of the syringe body. It is therefore possible to use a full-surface adhesive label, which can be stuck to the syringe body as well as to the Luer lock thread and optionally also to the closure of the vessel.
  • the adhesive label can also be embodied or used as an inscription label which, in addition to fixing the Luer lock thread, can optionally also provide an indication of first opening.
  • the outside of the Luer lock thread and optionally also the outside of the closure have a surface structure which is particularly suitable for adhesion of an adhesive label equipped with pressure-sensitive adhesive.
  • the threaded element and possibly also the closure are designed in particular to match the adhesive label to be attached and vice versa.
  • the threaded element and possibly also the closure have, for example, surface structures with macroscopic and/or microscopic features and/or are made from preselected materials in order to ensure a particularly stable hold of the adhesive label and to set up a reliable fixation of the threaded element relative to the vessel body.
  • the outer sides of the Luer lock thread and/or the closure can be designed with a relatively large area, which is circumferentially the same as the syringe body, in order to provide a correspondingly large adhesive surface for the adhesive label.
  • the surface structure of the outside of the Luer lock thread and/or the closure contains macroscopic bulges which correspond to corresponding punchings in the adhesive label. The bulges on the outside of the Luer lock thread and/or the closure can be inserted through such punch-outs in the adhesive label, which results in mechanical interlocking and contributes to a particularly stable hold.
  • the bulges on the outside of the Luer lock thread and/or the closure can, for example, have regularly or irregularly distributed nubs or alternatively be designed as continuous, outwardly protruding structures which are essentially perpendicular to the longitudinal axis of the syringe or extend obliquely to this.
  • Such bulges can have a size of 0.5 mm to 5 mm, for example.
  • Bulges on the threaded element and/or the closure of a Luer lock system can also have a size in a range from 1 mm to 2 mm. It is therefore useful to provide correspondingly large cutouts in the adhesive label, which are matched to the dimensions of the bulges and are preferably designed to be slightly larger.
  • the area on the outside of the Luer lock thread and/or the closure provided for attaching the adhesive label can be as smooth as possible in order to achieve the best possible adhesion of the adhesive of the adhesive label.
  • plastics with high surface energy at least for the outer area intended for adhesion to the adhesive label which can improve wetting with adhesive.
  • the surface energy of the material represents a measure of how strongly a pressure-sensitive adhesive spreads on the material.
  • plastics with a relatively high surface energy are polycarbonate and polyethylene terephthalate (PET).
  • PET polyethylene terephthalate
  • plastics can be subjected to plasma or corona treatment in order to specifically increase the surface energy.
  • a thread element made of polyethylene provides a relatively low surface energy.
  • Suitable adhesives for low-energy surfaces are, for example, rubber or silicone adhesives.
  • a pressure-sensitive adhesive of the pressure-sensitive label is therefore preferably matched to a material of the threaded element and/or the closure, or vice versa.
  • Adhesives that are particularly flowable are, for example, modified acrylates and synthetic rubber.
  • the closure of the vessel can also be adapted to an adhesive label to be attached.
  • the surface can be divided in two in one area of the closure. A lower part of the closure, which faces the threaded element, is then designed specifically for adhesion of the adhesive label, for example, while the upper part, which faces away from the threaded element, has gripping aids, such as ribbing, for example, which have a preferred feel for opening the provide vessel.
  • the closure prefferably has at least two layers from the outside to the inside, with an outermost layer for the attachment of the adhesive label being designed in a predetermined manner and an innermost layer of the closure meeting the requirements of a primary packaging component.
  • the Luer lock thread or the threaded element and the closure of the vessel can be connected to one another with holding webs. These then serve, for example, as a feature for the first opening display. In such a case, it is sufficient if the adhesive label only reaches as far as a dividing line between the Luer lock thread and the closure or if it is applied accordingly to the vessel, so that the Luer lock thread element is fixed to the syringe body.
  • the adhesive label can reach the closure of the vessel.
  • the adhesive label then has a perforation in the area below the closure, for example, and an adhesive neutralization above the perforation.
  • the adhesive label tears along the perforation so that the upper part can be removed together with the cap.
  • An at least partial double-layered nature of the adhesive label allows a colored area and/or lettering to be exposed by opening and removing the closure and a label segment, as a result of which an initial opening can be indicated even more clearly.
  • a suitable perforation optionally together with a bulge in the adhesive label as a grip tab, makes it possible for the adhesive label below the closure to be destroyed in a rotating manner with the tear-off strip, and the closure together with the upper partial element of the adhesive label, which was arranged above the tear-off strip, can be removed.
  • the Luer lock thread is always at least partially glued to the remaining adhesive label even after the closure has been removed and is thereby connected to the syringe body, so that the Luer lock thread continues to be fixed to the syringe.
  • the adhesive label can also be designed and applied to the vessel in such a way that before the syringe is opened, only the Luer lock thread is caught by the adhesive label and fixed relative to the syringe body.
  • closure and/or the Luer lock thread are not flush with the casing or the outer circumference of the syringe and a diameter of the closure and/or a diameter of the Luer lock thread is larger than a diameter of the syringe body, an existing step in a transition from the closure to the Luer lock thread and/or in a transition from the Luer lock thread to the syringe body can be compensated for by a partial multi-layer nature of the adhesive label.
  • certain differences in diameter can already be overcome by the comb structure.
  • the adhesive label can contain an RFID tag or an RFID transponder, which is connected to a printed conductor track. If this conductor track runs over a dividing line between the closure and the threaded element or the syringe body, it is specifically destroyed when the syringe is opened for the first time. Such an interruption in the conductor track can be detected and read using RFID technology.
  • the RFID transponder can be integrated in the area of the adhesive label in the case of a Luer lock thread and/or closure, which are designed with the same circumference as the syringe body, which is on the Luer Lock thread and / or the closure is glued, so that when reading there is no adverse interaction with the content, which is located in the syringe body.
  • the Figures 1-4 show exemplary embodiments of an adhesive label 10 for a multi-part vessel 30, which can be produced inexpensively and enables a threaded element 31 of the vessel 30 to be reliably fixed relative to a vessel body 32 of the vessel 30.
  • the adhesive label 10 can be used to provide reliable evidence of first opening in relation to the vessel 30 provided with the adhesive label 10 .
  • the adhesive label 10 has a first label section 11 and a second label section 12 adjoining the first label section 11 .
  • the first label section 11 is designed to be attached, in particular glued, to the threaded element 31 in a state applied to the vessel 30 .
  • the second label portion 12 is designed to be attached to the vessel body 32 of the vessel 30 (see Fig figures 5 , 6 and 9 ).
  • the two label sections 11 and 12 of the adhesive label 10 preferably form mutually adjacent parts of a common web of material.
  • the first label section 11 is flat.
  • the second label section 12 has a comb-like structure 13 with a plurality of strip-shaped fixing elements 131, 132, which are designed to be attached to the vessel body 32 of the vessel 30, so that the adhesive label 10, the threaded element 31 with the Vessel body 32 couples and movement of the threaded member 31 relative to the vessel body 32 counteracts.
  • the threaded element 31, which is usually placed and plugged onto the vessel body 32, can be reliably fixed and secured against undesired twisting. It is a finding in connection with the present invention that simply fastening the threaded element 31, for example to the vessel 30 in the form of a syringe, is often not sufficient. It can happen that when a syringe needle is screwed in, a simple mechanical or adhesive coupling between the threaded element 31 and the syringe body 32 may not withstand and the threaded element 31 rotates undesirably, especially if the user does not hold the threaded element 31 when screwing in the syringe needle.
  • the Figures 1 and 2 show an embodiment of the adhesive label 10 each in a schematic view.
  • the second label section 12 has a plurality of fixing elements 131 and 132 which are aligned differently.
  • the second label section 12 has four fixing elements 131 and three fixing elements 132, which are aligned with one another and each have a enclose an angle A1 or A2 with the edge of the first label section 11 facing them.
  • the four fixing elements 131 are aligned essentially parallel to one another.
  • the three fixing elements 132 are also aligned essentially parallel to one another.
  • a different number of fixing elements 131 and 132 can also be formed.
  • the same number of fixing elements 131 and 132 can also be formed on both sides, or the adhesive label 10 has more fixing elements 132 and 131 than fixing elements.
  • the angle A1 is in particular smaller than 90° and the angle A2 is in particular greater than 90°.
  • the fixing elements 131 and 132 are oriented towards one another and overlap on the vessel body 32 in a diamond shape.
  • the adhesive label 10 has a predetermined length L, which is designed in particular to match a circumference of the vessel 30 or the vessel body 32 and/or the threaded element 31 .
  • the adhesive label 10 preferably implements an wrap-around label, so that the length L is greater than the circumference of the threaded element 31 and/or the container body 32.
  • the adhesive label 10 particularly preferably has a length L1 in the section in which the fixing elements 131 are formed, which is designed in such a way that it approximately corresponds to the circumference of the vessel body 32 to which the adhesive label is to be attached.
  • the fixing elements 132 of the comb-like structure 13 come to lie crossed on the fixing elements 131 or vice versa. This counteracts the rotation of the threaded element 31 in a particularly reliable manner.
  • the length L is approximately equal to the circumference of the vessel 30, so that the adhesive label 10 forms a wrap-around label.
  • the length L of the adhesive label 10 can also be smaller than a circumference of the vessel 30, so that the adhesive label 10 covers only a portion of an outer surface of the threaded element 31 and/or the vessel body 32 in relation to the circumference.
  • the fixing elements 131 and 132 can be oriented away from one another, so that, for example, the fixing elements 131 enclose an angle A2 and the fixing elements 132 enclose an angle A1 with the first label section 11 .
  • the adhesive label 10 can be single-layer or multi-layer. In terms of height or width, the adhesive label 10 can cover the vessel 30 partially or completely from the bottom to the top or extend from a base end of the vessel body 32 to a head end of a closure 33 of the vessel 30 (see also figure 5 ). Alternatively, the adhesive label 10 can also extend beyond the height or width of the vessel 30 and can also be attached to the closure 33 of the vessel 30 in addition to an outside.
  • FIGs 3 and 4 show further exemplary embodiments of the adhesive label 10 in a schematic view, in which four fixing elements 131 are provided in each case are arranged essentially in the same orientation.
  • the adhesive label 10 has an adhesive layer 15 which completely or partially covers an underside of the adhesive label 10 .
  • the adhesive layer 15 serves in particular for the simple and reliable attachment of the adhesive label 10 to the threaded element 31 and the vessel body 32.
  • the adhesive label 10 has a continuous adhesive layer 15 and forms a completely adhesive underside.
  • the adhesive label 10 has an area 113 free of adhesive, which is specifically designed to match an area in which a severing element 14 is provided.
  • the severing element 14 can in particular be designed in the form of a perforation, which enables the adhesive label 10 to be severed in a simple and controlled manner.
  • An upper, first partial element 111 of the first label section 11 is glued to the closure 33 of the receptacle 30 before the receptacle 30 is opened, while a second, lower partial element 112 is attached to the threaded element 31 of the receptacle 30 .
  • the area 113 free of adhesive and the severing element 14 are then assigned to a transition area between the closure 33 and the threaded element 31 .
  • the container 30 applied with the adhesive label 10 When the container 30 applied with the adhesive label 10 is opened, it can be severed in a predetermined manner along the severing element 14 so that the first partial element 111 together with the closure 33 can be removed from the second partial element 112 and the container body 32 .
  • a removable partial element 111 can in particular also be used for documentation purposes and can be stuck in a patient file, for example.
  • FIGS. 5 to 6 show various exemplary embodiments of a system 1, which comprises the vessel 30 with the threaded element 31, the vessel body 32 and the closure 33, as well as an embodiment of the adhesive label 10.
  • the closure 33 is coupled to the vessel body 32 in a twist-off or peel-off manner such that the threaded member is disposed between the closure 33 and the vessel body 32 .
  • the container 30 or the closure 33 and the adhesive label 10 are designed to match one another, so that nub-shaped bulges 34 on an outside of the closure 33 are taken into account by means of complementary recesses 16 in the first label section 11 .
  • the recesses or recesses 16 of the adhesive label 10 can be formed by punching out predetermined geometries.
  • the upper section of the vessel 31, 33 can in particular represent a thread of a Luer lock system of a COC/COP syringe. This in figure 5
  • the exemplary embodiment shown represents a possibility for macroscopic interlocking of the adhesive label 10 with the outside of the Luer lock thread 31.
  • the figure 6 shows a further exemplary embodiment of the system 1, in which the vessel 30 or the Luer lock thread 31 and the adhesive label 10 are designed to match one another.
  • the closure 33 or the threaded element 31 has an elongate, annular bead or elevation 35 which is accommodated by a correspondingly elongate recess 16 in the first label section 11 of the adhesive label 10 .
  • the second label section 12 is attached to the vessel body 32 and couples the threaded element 31 to the vessel body 32 such that relative movement of the two components is prevented or at least counteracted.
  • the adhesive label 10 can be designed over the entire surface or preferably, as in the Figures 1 to 4 illustrated, have a comb-like structure 13 which forms the second label section 12 .
  • the figure 7 shows in a schematic sectional representation the vessel 30 with the closure 33 which is coupled by means of a plurality of connecting webs 36 to the exposed or attached threaded element 31 .
  • the threaded element 31 is, for example, mechanically hooked to the vessel body 32 and coupled in a non-positive and/or positive manner, or alternatively or optionally additionally glued to it.
  • the threaded element 31 is secured against undesired twisting relative to the vessel body 32 by means of the adhesive label 10 to be attached.
  • the figure 8 shows a further embodiment of the vessel 30, which has a structure similar to that in figure 7 having.
  • the figure 9 schematically illustrates the system 1, in which the adhesive label 10 on the vessel 30 according to the figures 7 and 8th is attached.
  • the figure 9 also shows an open state of the vessel 30.
  • the closure 33 was removed from the vessel body 32 by turning and/or pulling, and the vessel 30 was thus opened.
  • the connecting webs 36 are broken open by turning and/or pulling off the closure 33 and remain coupled to the closure 33 or to the vessel body 32 as partial segments 361 and 362 of a respective connecting web 36 .
  • the broken connecting webs 36 or the remaining sub-segments 361 and 362 can in particular provide proof of first opening, which clearly indicates that a first opening has already taken place.
  • the adhesive label 10 can only have a severing region apart from the threaded element 31 and itself.
  • the adhesive label 10 can extend to the closure 33 and additionally have a severing area 141 (see Fig. Figures 10 to 12 ).
  • figure 10 1 shows an embodiment of the system 1 with the adhesive label 10, which extends to the closure 33 of the vessel 30 and which has the severing area 141 with the severing element 14 in the form of one or more perforations between the first and second label sections 11 and 12 .
  • the perforation enables the adhesive label 10 to be torn in a controlled and predetermined manner and is introduced into the adhesive label 10 as a specifically designed weakening line.
  • the Figures 11 and 12 show further exemplary embodiments of the system 1, which are based on an embodiment according to FIG figure 10 can be based.
  • the Figures 11 and 12 each illustrate an open state of the vessel 30 in which a first opening that has taken place is indicated by means of an opening detection element 18 of the adhesive label 10 .
  • the adhesive label 10 was severed in a predetermined manner when the container 30 was opened, so that the upper, first partial element 111 of the first label section 11 remains on the closure 33 and the lower, second partial element 112 of the first label section 11 remains on the threaded element 31 of the container 30.
  • the opening verification element 18 provides a clearly recognizable indication in the form of lettering that the vessel 30 is open or that an initial opening has already taken place.
  • the opening detection element 18 can by a at least partial double or multiple layers of the adhesive label 10 may be provided.
  • the first label section 11 has a double-layer design and has the lettering "OPEN" in the severing area 141 on a lower label layer that faces the threaded element 31 .
  • the first partial element 111 of the first label section 11 then extends, for example, to the second partial element 112 or at least to a section of the second partial element 112 and covers the lettering when the container 30 is not open or the adhesive label 10 is not severed, so that the opening detection element 18 cannot yet be seen from the outside.
  • the first label section 11 can be detachable from the second label section 12 so that the first label section 11 covers part of the second label section 12 and there is a double layer in the area of the opening detection element 18 .
  • the first partial element 111 or the first label section 11 is removed together with the closure 33 .
  • the overlapping area between the first and second partial elements 111 and 112 or between the first and second label portions 11 and 12 is separated and the opening detection element 18 is exposed.
  • FIG 12 shows a further embodiment of the adhesive label 10, in which the opening detection element 18 has a first sub-element 181 and a second sub-element 182.
  • the first partial element 181 can be designed as an extended section of the first label section 11 or of the upper, first partial element 111, which covers the second partial element 182 when the vessel 30 is in an unopened state.
  • the adhesive label 10 has a perforation in the area of the opening element 18, for example, which tears in a predetermined manner when the container 30 is opened and the closure 33 is removed. In this way, the second partial element 182 is uncovered, which is designed, for example, as a clearly recognizable colored area.
  • the colored surface of the second partial element 182 serves as a first-opening indication, but the first partial element 181 of the opening verification element 18 protruding from the first partial element 111 of the first label section 11 also forms a recognizable first-opening indication as a label flag.
  • FIG 13 shows an exemplary embodiment of a flowchart of a method for applying or attaching the adhesive label 10 to the multi-part vessel 30.
  • the vessel 30 is provided with the threaded element 31 and the vessel body 32 and optionally with the closure 33.
  • the container 30 can be designed in accordance with the adhesive label 10 to be attached and can provide, for example, a flush surface structure 37 that is useful for reliably adhering the adhesive label 10 (see Fig. figure 10 ).
  • the surface structure 37 on the outside of the threaded element 31 and/or the closure 33 can be roughened in a targeted manner and, due to the roughness, enable advantageous adhesion.
  • the adhesive label 10 is provided with the first and second label sections 11 and 21.
  • the adhesive label 10 can be provided in particular with the adhesive layer 15 and a comb-like structure 13, which enable reliable attachment to the vessel and an undesired rotation of the threaded element 31 counteract relative to the vessel body 32.
  • the adhesive label 10 can also be provided with one or more recesses 16, which allow for a corresponding surface structure 37 with elevations 34 and/or 35.
  • the adhesive label 10 is attached to the vessel 30 in such a way that the first label section 11 is attached to the threaded element 31 and optionally also to the closure 33 of the vessel 30 .
  • step S3 the adhesive label 10 is attached to the vessel 30 in such a way that the second label section 12 is attached to the vessel body 32 of the vessel 30 .
  • Steps S2 and S3 can be carried out sequentially, simultaneously or in reverse order. It is ensured in each case that the adhesive label 10 is applied to the vessel 30 in such a way that it couples the threaded element 31 to the vessel body 32 and counteracts a movement of the threaded element 31 relative to the vessel body 32 .
  • the adhesive label 10 described enables a Luer lock thread of a syringe to be reliably fixed in place in a simple and cost-effective manner, so that the threaded element 31 is counteracted when the vessel 30 is opened or a syringe needle is screwed in.
  • This relates in particular to syringes made of glass or plastic and having a plastic Luer lock thread.
  • the thread is fixed to the syringe, but may not be sufficiently connected to the syringe body to be able to withstand torsional forces.
  • the force can be so great that the simple fixation breaks and causes the Luer-Lock thread to spin.
  • erroneous attachment of the syringe needle to the vessel 30 may also occur.
  • the adhesive label 10 can contribute to a stable and reliable hold of the threaded element 31 on the vessel body 32 .
  • the adhesive label 10 is wrapped, for example, around the syringe body 32 of the syringe 30 and around the Luer lock thread 31 and optionally also around a syringe cap or the closure 33 of the syringe 30 .
  • a selection of a pressure-sensitive adhesive for the adhesive layer 15 can be made in particular in accordance with a microscopic surface finish of the syringe body 32, the Luer lock thread 31 and/or the closure 33.
  • the adhesive label 10 can be used to perform other functions, such as a first-opening indicator (also electronically using an integrated RFID functionality) and protection against UV radiation, the ingress or egress of a solvent, humidity and/or other small molecule substances.
  • a first-opening indicator also electronically using an integrated RFID functionality
  • protection against UV radiation the ingress or egress of a solvent, humidity and/or other small molecule substances.

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  • Engineering & Computer Science (AREA)
  • Physics & Mathematics (AREA)
  • General Physics & Mathematics (AREA)
  • Theoretical Computer Science (AREA)
  • Computer Security & Cryptography (AREA)
  • Closures For Containers (AREA)
  • Medical Preparation Storing Or Oral Administration Devices (AREA)
  • Details Of Rigid Or Semi-Rigid Containers (AREA)
EP22199776.0A 2019-12-18 2020-11-12 Système comprenant une seringue et une étiquette adhésive Pending EP4152300A1 (fr)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
DE102019134927.3A DE102019134927A1 (de) 2019-12-18 2019-12-18 Haftetikett für ein mehrteiliges Gefäß, System und Verfahren zum Applizieren eines Haftetiketts an einem mehrteiligen Gefäß
EP20807690.1A EP4078562A1 (fr) 2019-12-18 2020-11-12 Étiquette adhésive pour récipient à parties multiples, système et procédé d'application d'une étiquette adhésive sur un récipient à parties multiples
PCT/EP2020/081865 WO2021121796A1 (fr) 2019-12-18 2020-11-12 Étiquette adhésive pour récipient à parties multiples, système et procédé d'application d'une étiquette adhésive sur un récipient à parties multiples

Related Parent Applications (1)

Application Number Title Priority Date Filing Date
EP20807690.1A Division EP4078562A1 (fr) 2019-12-18 2020-11-12 Étiquette adhésive pour récipient à parties multiples, système et procédé d'application d'une étiquette adhésive sur un récipient à parties multiples

Publications (1)

Publication Number Publication Date
EP4152300A1 true EP4152300A1 (fr) 2023-03-22

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EP22199776.0A Pending EP4152300A1 (fr) 2019-12-18 2020-11-12 Système comprenant une seringue et une étiquette adhésive
EP20807690.1A Pending EP4078562A1 (fr) 2019-12-18 2020-11-12 Étiquette adhésive pour récipient à parties multiples, système et procédé d'application d'une étiquette adhésive sur un récipient à parties multiples

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EP20807690.1A Pending EP4078562A1 (fr) 2019-12-18 2020-11-12 Étiquette adhésive pour récipient à parties multiples, système et procédé d'application d'une étiquette adhésive sur un récipient à parties multiples

Country Status (4)

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US (3) US20230021381A1 (fr)
EP (2) EP4152300A1 (fr)
DE (1) DE102019134927A1 (fr)
WO (1) WO2021121796A1 (fr)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP4142836A4 (fr) * 2020-11-02 2023-09-27 Becton, Dickinson and Company Incrustations d'identification par radiofréquence (rfid) destinées à être utilisées avec des dispositifs d'injection médicaux

Citations (4)

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US3523623A (en) * 1968-09-20 1970-08-11 Zapata Industries Inc Cover for cut edge projections of twist-off crowns for protecting the fingers of the user
EP1566786A1 (fr) * 2004-02-18 2005-08-24 Schreiner Group GmbH & Co. KG Etiquette et structure de deux corps scellée avec ladite étiquette.
EP2014570A1 (fr) * 2007-06-13 2009-01-14 Baxter International Inc. Système de conditionnement et son procédé d'utilisation
WO2013167701A1 (fr) * 2012-05-09 2013-11-14 Schreiner Group Gmbh & Co. Kg Élément de fermeture pour récipient

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US4540101A (en) * 1983-10-26 1985-09-10 Aluminum Company Of America Container assembly including a tamper-indicating band
CA2556038A1 (fr) * 2004-02-18 2005-09-29 Schreiner Group Gmbh & Co. Kg Etiquette pour sceller le passage entre des sections transversales differant dans le sens axial
JP4960676B2 (ja) * 2006-09-13 2012-06-27 テルモ株式会社 プレフィルドシリンジ
JP5430199B2 (ja) * 2009-03-31 2014-02-26 テルモ株式会社 医療用具

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3523623A (en) * 1968-09-20 1970-08-11 Zapata Industries Inc Cover for cut edge projections of twist-off crowns for protecting the fingers of the user
EP1566786A1 (fr) * 2004-02-18 2005-08-24 Schreiner Group GmbH & Co. KG Etiquette et structure de deux corps scellée avec ladite étiquette.
EP2014570A1 (fr) * 2007-06-13 2009-01-14 Baxter International Inc. Système de conditionnement et son procédé d'utilisation
WO2013167701A1 (fr) * 2012-05-09 2013-11-14 Schreiner Group Gmbh & Co. Kg Élément de fermeture pour récipient

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP4142836A4 (fr) * 2020-11-02 2023-09-27 Becton, Dickinson and Company Incrustations d'identification par radiofréquence (rfid) destinées à être utilisées avec des dispositifs d'injection médicaux

Also Published As

Publication number Publication date
US20230298486A1 (en) 2023-09-21
US20230021381A1 (en) 2023-01-26
DE102019134927A1 (de) 2021-06-24
WO2021121796A1 (fr) 2021-06-24
US20230023532A1 (en) 2023-01-26
EP4078562A1 (fr) 2022-10-26

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