EP4126180A2 - Élément de support pour micro-aiguilles et dispositif à réseau de micro-aiguilles - Google Patents

Élément de support pour micro-aiguilles et dispositif à réseau de micro-aiguilles

Info

Publication number
EP4126180A2
EP4126180A2 EP21713349.5A EP21713349A EP4126180A2 EP 4126180 A2 EP4126180 A2 EP 4126180A2 EP 21713349 A EP21713349 A EP 21713349A EP 4126180 A2 EP4126180 A2 EP 4126180A2
Authority
EP
European Patent Office
Prior art keywords
microneedles
microneedle array
carrier element
microneedle
forming
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
EP21713349.5A
Other languages
German (de)
English (en)
Inventor
Andreas Henning
Sebastian SCHERR
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
LTS Lohmann Therapie Systeme AG
Original Assignee
LTS Lohmann Therapie Systeme AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by LTS Lohmann Therapie Systeme AG filed Critical LTS Lohmann Therapie Systeme AG
Publication of EP4126180A2 publication Critical patent/EP4126180A2/fr
Pending legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M37/00—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin
    • A61M37/0015—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin by using microneedles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M37/00—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin
    • A61M37/0015—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin by using microneedles
    • A61M2037/0023—Drug applicators using microneedles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M37/00—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin
    • A61M37/0015—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin by using microneedles
    • A61M2037/0046—Solid microneedles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M37/00—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin
    • A61M37/0015—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin by using microneedles
    • A61M2037/0053—Methods for producing microneedles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M2209/00—Ancillary equipment
    • A61M2209/06—Packaging for specific medical equipment
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M2209/00—Ancillary equipment
    • A61M2209/08—Supports for equipment

Definitions

  • the invention relates to a carrier element for microneedles for forming a microneedle array or a microneedle array device.
  • the invention also relates to a microneedle array device.
  • Microneedles are used to deliver active ingredients directly into the skin, also known as trans dermal administration.
  • the microneedles are of such a length that they only penetrate into the outer layers of the skin, but preferably not to reach nerves and blood vessels and thus leave them unharmed. Nevertheless, microneedles create small holes in the upper layers of the skin, which significantly increases the absorption of active ingredients compared to a purely external application of active ingredients to the skin.
  • Microneedle arrays which have a multiplicity of microneedles, for example attached to a carrier surface, can be used for short-term administration or for long-term application.
  • a preferred option for the release of active ingredient from the microneedles into the skin consists in that areas of the microneedles or the entire microneedle that contain active substance dissolve or detach and are thus absorbed by the body through the skin.
  • the microneedles are in particular, at least partially, made of water-soluble substances or materials.
  • the microneedles it is also possible for the microneedles to have pores or cavities or to be designed as hollow needles in order to enable active ingredient to be released to the skin in this way.
  • microneedles can in themselves also be free of active ingredients.
  • the active ingredient can be applied externally to the outside of the microneedles or only after the microneedles have been removed from the skin can an active substance-containing substance be applied to the corresponding area of the skin in order to administer such active substances by using microneedles.
  • Microneedles can be made of ceramic, metal or polymer, among other things. It is preferred that one or more active ingredient components are added to these materials and such a formulation of the microneedles results.
  • a common method for producing microneedles consists of casting the microneedles or entire microneedle arrays, for example by means of a mold such as matrices made of silicone.
  • a mold such as matrices made of silicone.
  • a first liquid or formulation provided with an active ingredient is dosed onto the die so that the depressions forming the microneedles are partially filled with the first liquid.
  • a second liquid which usually does not contain any active substance, is dosed onto the die so that, on the one hand, the depressions are completely filled and a closed cover layer that connects the needles is produced.
  • the problem here is that the two liquids mix because the second liquid must at least partially dissolve the first liquid or the first liquid must not yet be completely dry in order to connect the two Ensure liquids.
  • migration of the active substance into the second or a back layer can occur, so that the availability of the active substance is reduced.
  • a long drying process is required.
  • the microneedle array is usually placed on the skin and the needles are applied to the back of the microneedle array by applying even pressure. With such a manual application, it is extremely difficult to exert an even and uniform force on all needles.
  • microneedle arrays are also known for applying microneedle arrays.
  • the microneedle array must first be arranged on the applicator with the aid of an adhesive film. This is also difficult and can damage individual needles.
  • microneedle arrays have to be packaged individually, usually sterile. This is usually done with the help of a blister, i.e. a particularly transparent packaging film. In order to meet the sterile requirements, it is necessary that the blister is welded or sealed. A seal on an adhesive layer is associated with a lot of effort. In particular, not all adhesives are suitable for this.
  • a carrier element for microneedles for forming a microneedle array is known.
  • Such a carrier element has a plate-shaped base element.
  • Receiving elements are provided on a front side of the base element.
  • the front of the base element is the side that points in the direction of the microneedles.
  • the receiving elements are frustoconical and have a front side on which the conical microneedle is then arranged.
  • the carrier element is arranged on the die in such a way that the frustoconical receiving elements protrude into the depressions and a connection is made between a front side of the receiving elements and the material forming the microneedles.
  • the object of the invention is to create a carrier element by means of which a better connection with the microneedles can be realized.
  • Another object of the invention, independent of this object, is to provide an improved microneedle array device.
  • the object is achieved by a carrier element with the features of claim 1 or a microneedle device with the features of claim 12.
  • the carrier element according to the invention for microneedles for forming a microneedle array has a plate-shaped base element.
  • Receiving elements are provided on a front side of the base element.
  • the recording elements are used to connect, in particular, to a respective microneedle of the microneedle array.
  • the front side of the base element is thus that side which points in the direction of the microneedles when the carrier element is connected to microneedles.
  • a connecting element is provided on each of the receiving elements.
  • Such a connecting element is provided in particular on the front side of the receiving elements, but can also be provided on a side surface of the receiving elements or both a side surface and on the front side of the receiving elements.
  • connection elements are designed according to the invention in such a way that they have an undercut in the longitudinal direction.
  • the longitudinal direction is the center line or Symmetrieli never of the individual receiving elements and microneedles.
  • the longitudinal direction is the demolding direction, ie that direction or axis in which the carrier element is demolded from a die together with the microneedles. Due to the undercut according to the invention in the longitudinal direction, the material of the microneedles engages around or engages behind the receiving elements or a connecting element provided on the receiving elements, at least partially. A significantly better connection is realized by such an undercut. Since it is preferred that the receiving elements of the carrier element are inserted into the recesses of the die as long as the liquid previously dosed into the recesses has not yet hardened, or at least not completely hardened, the liquid easily reaches the corresponding undercut areas.
  • the connecting elements can be lugs, or the connecting elements can have lugs, whereby it is of course possible for a carrier element to have different connecting elements and / or combinations of different connecting elements on different receiving elements.
  • these extend in the longitudinal direction and form an undercut in the preferred embodiment. This is achieved in particular in that the cross section of the lugs tapers in the longitudinal direction; ie starting from the microneedle, the extension tapers in the direction of the front side of the base element, ie in particular in the longitudinal direction.
  • the approaches preferably have a groove for cross-sectional tapering. This can be circumferential and thus in particular be designed in the shape of a ring. In a side view, it is therefore particularly preferred that the attachments are mushroom-shaped.
  • the approaches thus have a cylindrical web with in particular special round or polygonal cross-section. This is connected to a thickening, such as a head.
  • the connecting elements are designed as depressions, transverse bores or the like in the receiving elements. Even the provision of depressions, transverse bores or the like, which at least partially do not extend in the longitudinal direction, leads to the formation of an undercut. During production, the at least still viscous material in the microneedles penetrates into these depressions, cross holes or the like. After curing, a reliable, in particular form-fitting, connection is made through the undercut.
  • connecting elements provided as depressions, transverse bores or the like can of course be combined with the connecting elements described above, in particular designed as approaches.
  • the connecting elements are at least partially or completely designed as channels that extend into the receiving element.
  • the channels are arranged in such a way that they at least partially do not extend in the longitudinal direction or have an angle of ⁇ 0 ° to the longitudinal direction.
  • the cross section of the channels widens in the longitudinal direction to form an undercut. Starting from the front side of the receiving elements, such channels thus preferably extend in the direction of the front side of the base element and have at least one in this direction Cross-sectional expansion on. As a result, an undercut is realized by the material of the microneedles penetrating into the channel.
  • the channel or another recess in the receiving element preferably has a volume which is greater than the volume of the liquid which is usually to be taken up during the manufacture, from which the microneedle is manufactured. This makes it possible to absorb excess material and establish a secure connection. If necessary, the channel can extend as far as the rear of the base element, so that even an escape of liquid would be possible.
  • the support element is at least partially made of a material that absorbs solvent.
  • the material is thus suitable for taking up the solvent present in the liquid forming the microneedle. This is advantageous because it is then possible to insert the carrier element into the recesses of the die when the material forming the needle is still in a very liquid state, since the material forming the needles will harden due to the absorption of solvent by the carrier element .
  • the receiving elements of the carrier elements have such a material.
  • the carrier element can be received in a simple manner by an applicator.
  • the holder can be, for example, a substantially cylindrical, pin-shaped approach. This can have a circumferential groove in order to interact, for example, with a latching connection on the applicator.
  • connection surface is an adhesive surface.
  • a packaging element such as in particular a packaging film such as a blister, can be provided on the adhesive surface. This makes it possible in a simple manner to pack the microneedles, in particular sterile. Because of the connection between the packaging element and the carrier element, easy removal is possible. In particular, when removing, the risk of damaging the microneedles is significantly reduced.
  • the edge area is preferably formed around the edge, in particular in the shape of a frame.
  • the invention further relates to a microneedle array with a carrier element, where the carrier element is designed and advantageously developed as described above. At least on some of the receiving elements, in particular on each receiving element, a microneedle is provided or is arranged. This invention thus relates to a microneedle array produced with the aid of the carrier element described above.
  • the invention also relates to a microneedle array device.
  • One of the type of device has a carrier element which has at least one plate-shaped base element and provided on a front side of the base element Has receiving elements for connection to a respective microneedle of the microneedle array.
  • the connecting elements described above in particular in a preferred development, do not have to be provided, it being particularly preferred according to the invention that such connecting elements are provided, in particular in the preferred embodiments described above.
  • microneedles are connected to the receiving elements.
  • a packaging element is provided by means of which the microneedles are packaged in a sterile manner, in particular.
  • the packaging element is, as described above with reference to the Trä gerelements, preferably arranged on an edge region of the respectivelyele element.
  • the connection is preferably made via a connection surface provided on the front side and / or the rear side of the base element of the carrier element.
  • the packaging element can also be designed in such a way that it has a recess.
  • the recess serves to receive the carrier element, the recess being closed in a preferred embodiment at least on one side, in particular with a packaging film.
  • the film is preferably designed in such a way that it can be peeled off.
  • a packaging film or the like is preferably arranged on the side on which the microneedles are arranged. After removing the packaging film, it is thus possible in a simple manner to push the carrier element out of the recess and to apply the needles, in particular directly.
  • a packaging film can also be provided on the opposite side, ie in the area of the rear side of the carrier element. This is particularly advantageous when the carrier element has a holder for connection to an applicator.
  • a packaging film in particular also peelable, can then be removed, and the applicator can then be connected to the holder immediately afterwards. It is then possible to use the applicator in FIG In the direction of the applicator. If a corresponding foil is provided on both sides, it is also possible to remove the foil provided on the side of the micro needles and to move the Trä gerelement in this direction with the help of the applicator and to apply the microneedles directly.
  • the carrier element of the microneedle device is preferably, as explained above, advantageously developed.
  • a die with a large number, in particular conical, depressions is used.
  • the depressions are used to form the microneedles.
  • a liquid in particular provided with an active ingredient, is dosed into the recesses of the die.
  • the depressions are only partially filled.
  • a carrier element according to the invention is inserted into the recesses of the die in such a way that the receiving elements protrude into the recesses and the liquid is connected to the receiving elements due to the connecting elements connected to the receiving elements. This is done in particular in such a way that the liquid connects to the connecting elements in such a way that these are partially enclosed or grasped behind. An undercut is thus formed.
  • Figure 1 is a schematic perspective view of a first Aussch approximately form of a carrier element from below
  • Figure 2 is a schematic sectional view of the support element shown in Figure 1 along the line II-II,
  • Figure 3 is a schematic sectional view of a die
  • Figure 4 is a schematic sectional view of the support element shown in Figures 1 and 2 in connection with the die shown in Figure 3,
  • Figure 5 is a schematic perspective view of a second embodiment of a carrier element from below
  • Figure 6 is a schematic sectional view of the support element shown in Figure 5 along the line VI-VI,
  • Figure 7 is a schematic sectional view of the support element shown in Figures 5 and 6 in connection with the die shown in Figure 3,
  • Figure 8 is a schematic sectional view of the in Figures 5 and 6 according to an alternative embodiment
  • Figure 9 is a schematic side view of a further embodiment of the carrier element.
  • FIG. 10 shows a first preferred embodiment of a microneedle array device based on the carrier element shown in FIG. 9
  • FIG. 11 shows a second preferred embodiment of a microneedle array device based on the carrier element shown in FIG. 9 and
  • FIG. 10 shows a first preferred embodiment of a microneedle array device based on the carrier element shown in FIG. 9
  • FIG. 11 shows a second preferred embodiment of a microneedle array device based on the carrier element shown in FIG. 9
  • FIG. 10 shows a first preferred embodiment of a microneedle array device based on the carrier element shown in FIG. 9
  • FIG. 11 shows a second preferred embodiment of a microneedle array device based on the carrier element shown in FIG. 9 and
  • FIG. 10 shows a first preferred embodiment of a microneedle array device based on the carrier element shown in FIG. 9
  • FIG. 11 shows a second preferred embodiment of a microneedle array device based on the carrier element shown in FIG. 9 and FIG. 10
  • FIG. 12 shows a third preferred embodiment of a microneedle array device based on the carrier element shown in FIG. 12
  • a first embodiment of a carrier element (FIGS. 1 and 2) has a plate-shaped base element 10. On a front side 12 of the Basisele element 10, a plurality of frustoconical receiving elements 14 is arranged on. In the illustrated embodiment, only 9 such receiving elements are shown for reasons of clarity.
  • Each receiving element 14 has a connecting element 16 in the illustrated embodiment.
  • the connecting element 16 is designed as a channel which extends from a front side 18 of the receiving elements to a rear side 20 of the base elements.
  • the latter In a first part 24 of the channel 16 extending in the longitudinal direction 22, the latter has a smaller diameter than in a second section 26. Due to the different cross sections in the areas 24 and 26 of the channel 16, an undercut is formed.
  • a die 28 (FIG. 3) is used to produce the microneedle array.
  • the die 28 has a multiplicity of conical depressions 30.
  • the arrangement and number of the conical depressions 30 corresponds to the arrangement and the number of the receiving elements 14.
  • the depressions 30 are partially filled with a liquid 32.
  • the dosing of the liquid 32 which contains an active ingredient, takes place in such a way that the depressions 30 are only partially filled.
  • the carrier element is placed on an upper side 34 of the die 32 in such a way that the front side 12 of the base element 10 rests on the upper side 34 (in FIG. 4).
  • the receiving elements 14 are arranged in the depressions 30, the liquid 32 penetrating into the channel 16, in particular into the first channel section 24. Part of the liquid also penetrates into the channel section 26, so that (as can be seen from FIG. 4) an undercut takes place.
  • the carrier element is demolded in the longitudinal direction or in the demolding direction 22, it is thus ensured that the areas 22 of the liquid which form the microneedles remain firmly connected to the receiving elements 14 due to the undercut.
  • connecting elements 36 are seen as connecting elements on the front sides 18 of the receiving elements 14.
  • the connecting elements 36 are designed as lugs which are mushroom-shaped in cross section.
  • the lugs 36 thus have an in particular annular groove 38 in the longitudinal or in the demolding direction 22.
  • the groove 38 forms an undercut opposite a head-shaped element 40 of the lugs 36.
  • FIG. 7 shows an alternative embodiment to the embodiment shown in FIGS.
  • the connecting elements are formed identically. The only difference is that the receiving elements 14 have a longer shaft 42, so that the front side 12 of the base element 10 is at a distance from the upper side 34 of the die 28. In this way, 28 needles of different lengths can be produced in a simple manner using the same die.
  • FIG. 9 shows a further development of the second embodiment shown in FIGS.
  • a holder 34 is provided on the rear side 20 of the base element 10.
  • the Hal sion 44 is circular cylindrical and has an annular groove 46 on. Via the holder 44, it is possible to connect the carrier element to an applicator. For example, a latching connection which latches into the groove 46 can be used for reliable fixing.
  • the holder 44 could of course also be arranged on the rear side of the first embodiment shown in FIGS.
  • FIGS. 10 to 12 show different embodiments of a microneedle array device on the basis of the carrier element with holder 44 shown in FIG.
  • connection surface 50 is provided on the front side 12 of the base element 10 in an edge region 48.
  • the connecting surface 50 is in particular an adhesive surface.
  • the connection surface 50 is provided circumferentially on the front side 12 of the base element 10 and thus surrounds the receiving elements 14 in the shape of a frame.
  • a packaging film 52 provided on the adhesive surface 50, it is possible in a simple manner to Array, ie in particular the area that comes into contact with the patient, to be packaged in a sterile manner.
  • FIG. 1 An alternative packaging option is shown in FIG.
  • the corresponding packaging element 54 again in particular designed as a film, is guided around the edge region of the base element 10 in this exemplary embodiment.
  • the connecting layer 50 is again provided on the rear side 20 in the edge region 48.
  • This connecting layer is also designed in particular in the shape of a frame and encloses the entire base element 10.
  • the carrier element together with the needles 32 formed by the liquid, is arranged in an additional packaging 46.
  • the additional packaging 56 has a recess or opening 58 in which, in particular, the base element 10 of the support element is arranged.
  • the recess on the side of the microneedles 32 is closed by a packaging film 60 which is attached to the outside of the additional pack via adhesive surfaces 50.
  • a further packaging film 62 is provided opposite, which in turn has an adhesive surface 50 on an outside of the additional packaging 56.
  • the additional packaging shown in FIG. 12 provides protection for the entire carrier element including the holder 40 arranged on the rear side 20 of the base element 10.
  • the carrier element itself can be held in the opening 58 of the additional packaging 56 by latching hooks (not shown) or the like. This makes it possible to keep the carrier element in a defined position in a simple manner until, for example, a force is applied via the holder 44 by an applicator.
  • a semicircular groove having a cross section can be provided be. This makes it possible to mount the entire additional packaging 56 in an applicator or to take it up with an applicator. For application, it is then only necessary to remove the packaging film 60.

Landscapes

  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Medical Informatics (AREA)
  • Anesthesiology (AREA)
  • Biomedical Technology (AREA)
  • Dermatology (AREA)
  • Hematology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Media Introduction/Drainage Providing Device (AREA)
  • Knitting Machines (AREA)

Abstract

L'invention concerne un élément de support pour micro-aiguilles servant à former un réseau de micro-aiguilles, cet élément de support comprenant un élément de base (10) en forme de plaque. Des éléments de réception (14) destinés à être reliés à une micro-aiguille (32) respective du réseau de micro-aiguilles sont placés sur une face avant (12) de l'élément de base (10). En outre, des éléments de liaison (16, 36) sont prévus en particulier sur la face avant (18) des éléments de réception (14). Ces éléments de liaison (16, 36) sont conçus de telle sorte qu'ils présentent dans la direction longitudinale (22) un dégagement de sorte que les aiguilles (32) sont reliées de manière fiable aux éléments de réception (14).
EP21713349.5A 2020-04-02 2021-03-16 Élément de support pour micro-aiguilles et dispositif à réseau de micro-aiguilles Pending EP4126180A2 (fr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE102020109157.5A DE102020109157A1 (de) 2020-04-02 2020-04-02 Trägerelement für Mikronadeln sowie Mikronadelarray-Einrichtung
PCT/EP2021/056687 WO2021197836A2 (fr) 2020-04-02 2021-03-16 Élément de support pour micro-aiguilles et dispositif à réseau de micro-aiguilles

Publications (1)

Publication Number Publication Date
EP4126180A2 true EP4126180A2 (fr) 2023-02-08

Family

ID=75111577

Family Applications (1)

Application Number Title Priority Date Filing Date
EP21713349.5A Pending EP4126180A2 (fr) 2020-04-02 2021-03-16 Élément de support pour micro-aiguilles et dispositif à réseau de micro-aiguilles

Country Status (8)

Country Link
US (1) US20230146417A1 (fr)
EP (1) EP4126180A2 (fr)
JP (1) JP2023519222A (fr)
CN (1) CN115209940B (fr)
BR (1) BR112022016665A2 (fr)
CA (1) CA3173523A1 (fr)
DE (1) DE102020109157A1 (fr)
WO (1) WO2021197836A2 (fr)

Family Cites Families (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU2012211391A1 (en) * 2005-06-27 2012-08-23 3M Innovative Properties Company Microneedle cartridge assembly and method of applying
WO2008008558A1 (fr) * 2006-07-11 2008-01-17 Infotonics Technology Center, Inc. Système de test d'allergie peu invasif pourvu d'enrobages d'allergènes
US8821446B2 (en) 2007-01-22 2014-09-02 Corium International, Inc. Applicators for microneedles
JP5473996B2 (ja) * 2010-09-09 2014-04-16 株式会社バイオセレンタック 経皮吸収製剤包装投与器具
EP2654582B1 (fr) 2010-12-22 2017-05-31 Valeritas, Inc. Applicateur de timbre à micro-aiguilles
US10105524B2 (en) * 2012-12-27 2018-10-23 3M Innovative Properties Company Article with hollow microneedles and method of making
EP3028735A4 (fr) * 2013-07-30 2017-04-12 Asti Corporation Réseau de microaiguilles et procédé de fabrication de réseau de microaiguilles
JP5931110B2 (ja) * 2014-03-26 2016-06-08 日本写真印刷株式会社 錐体状突起シートの梱包体の製造方法
CN104056346B (zh) * 2014-06-16 2017-04-26 游学秋 异平面微针阵列及其制作方法
JP2016067723A (ja) * 2014-09-30 2016-05-09 日本写真印刷株式会社 経皮投与用貼付剤の製造方法及び経皮投与用貼付剤
JP6717203B2 (ja) * 2015-01-16 2020-07-01 凸版印刷株式会社 経皮投与デバイス収容体
KR20170044049A (ko) * 2015-10-14 2017-04-24 주식회사 주빅 겔형 고분자 물질을 이용한 마이크로구조체 및 이의 제조방법
CN108601932A (zh) * 2016-01-28 2018-09-28 株式会社理光 微针阵列和微针片
KR101796684B1 (ko) 2016-05-19 2017-11-10 건국대학교 산학협력단 케라틴 8 인산화 억제제를 포함하는 황반변성 예방 또는 치료용 약학 조성물 및 황반변성 치료제의 스크리닝 방법
CN109152914B (zh) * 2016-05-31 2021-06-22 日写株式会社 微针阵列及其制造方法
US20190350840A1 (en) * 2016-12-26 2019-11-21 Hisamitsu Pharmaceutical Co., Inc. Microneedle device
US20210060322A1 (en) 2018-01-09 2021-03-04 Evonik Corporation Wearable device with microneedle array delivery system
CN110478612B (zh) * 2019-07-15 2020-10-27 北京化工大学 尖端溶解法制备气泡式空心给药微针的方法

Also Published As

Publication number Publication date
CN115209940B (zh) 2024-01-30
JP2023519222A (ja) 2023-05-10
US20230146417A1 (en) 2023-05-11
WO2021197836A2 (fr) 2021-10-07
WO2021197836A3 (fr) 2022-01-13
CN115209940A (zh) 2022-10-18
DE102020109157A1 (de) 2021-10-07
CA3173523A1 (fr) 2021-10-07
BR112022016665A2 (pt) 2022-10-11

Similar Documents

Publication Publication Date Title
JP2010502267A (ja) マイクロニードルおよびマイクロニードルの製造方法
DE102008052749A1 (de) Nadel, Nadelanordnung, Spritzgussform und Verfahren zum Herstellen
EP3911402A1 (fr) Applicateur
WO2021197836A2 (fr) Élément de support pour micro-aiguilles et dispositif à réseau de micro-aiguilles
EP3209224A1 (fr) Bande alvéolaire
EP4106855A1 (fr) Réseau de micro-aiguilles, corps de façonnage pour fabriquer un réseau de micro-aiguilles et procédé pour fabriquer un réseau de micro-aiguilles
EP3893985A2 (fr) Procédé et dispositif de fabrication de micro-aiguilles
EP3911404A1 (fr) Applicateur
EP3013315B1 (fr) Dispositif doté d'un système thérapeutique transdermique, d'une aide au positionnement et d'une aide à la pénétration
EP4132632A1 (fr) Dispositif et procédé de fabrication d'un patch présentant plusieurs microstructures
WO2021165141A1 (fr) Élément de moulage pour la réalisation de microstructures
EP4221805A1 (fr) Procédé de production d'un élément de moule destiné à la production de micro réseaux et élément de moule
EP3108147B1 (fr) Dispositif servant à l'introduction d'une matière de fixation dans une ouverture
EP3911403A1 (fr) Cavité de réception de puce à adn
EP4017696A1 (fr) Dispositif et procédé de fabrication de microstructures
DE102021112136A1 (de) Verfahren und Vorrichtung zur Herstellung von Mikronadelelementen, sowie Mikronadelelement
EP4288262A1 (fr) Procédé de production d'un élément de moule permettant la production de microréseaux, et élément de moule
EP4277776A1 (fr) Procédé et système de production de microstructures
WO2021053079A2 (fr) Micro-aiguille et procédé de réalisation d'une micro-aiguille
WO2021204557A1 (fr) Dispositif de fabrication de microréseaux et procédé de fabrication d'un microréseau
WO2024156462A1 (fr) Dispositif d'application pour micro-aiguilles, système d'application de micro-aiguilles et procédé de production d'un système d'application de micro-aiguilles

Legal Events

Date Code Title Description
STAA Information on the status of an ep patent application or granted ep patent

Free format text: STATUS: UNKNOWN

STAA Information on the status of an ep patent application or granted ep patent

Free format text: STATUS: THE INTERNATIONAL PUBLICATION HAS BEEN MADE

PUAI Public reference made under article 153(3) epc to a published international application that has entered the european phase

Free format text: ORIGINAL CODE: 0009012

STAA Information on the status of an ep patent application or granted ep patent

Free format text: STATUS: REQUEST FOR EXAMINATION WAS MADE

17P Request for examination filed

Effective date: 20221102

AK Designated contracting states

Kind code of ref document: A2

Designated state(s): AL AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LI LT LU LV MC MK MT NL NO PL PT RO RS SE SI SK SM TR

REG Reference to a national code

Ref country code: HK

Ref legal event code: DE

Ref document number: 40081458

Country of ref document: HK

DAV Request for validation of the european patent (deleted)
DAX Request for extension of the european patent (deleted)