EP4288262A1 - Procédé de production d'un élément de moule permettant la production de microréseaux, et élément de moule - Google Patents

Procédé de production d'un élément de moule permettant la production de microréseaux, et élément de moule

Info

Publication number
EP4288262A1
EP4288262A1 EP22702399.1A EP22702399A EP4288262A1 EP 4288262 A1 EP4288262 A1 EP 4288262A1 EP 22702399 A EP22702399 A EP 22702399A EP 4288262 A1 EP4288262 A1 EP 4288262A1
Authority
EP
European Patent Office
Prior art keywords
base
auxiliary
base element
auxiliary element
embossing
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
EP22702399.1A
Other languages
German (de)
English (en)
Inventor
Olga GRÜNWALD
Michael Kulik
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
LTS Lohmann Therapie Systeme AG
Original Assignee
LTS Lohmann Therapie Systeme AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by LTS Lohmann Therapie Systeme AG filed Critical LTS Lohmann Therapie Systeme AG
Publication of EP4288262A1 publication Critical patent/EP4288262A1/fr
Pending legal-status Critical Current

Links

Classifications

    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B29—WORKING OF PLASTICS; WORKING OF SUBSTANCES IN A PLASTIC STATE IN GENERAL
    • B29C—SHAPING OR JOINING OF PLASTICS; SHAPING OF MATERIAL IN A PLASTIC STATE, NOT OTHERWISE PROVIDED FOR; AFTER-TREATMENT OF THE SHAPED PRODUCTS, e.g. REPAIRING
    • B29C59/00—Surface shaping of articles, e.g. embossing; Apparatus therefor
    • B29C59/02—Surface shaping of articles, e.g. embossing; Apparatus therefor by mechanical means, e.g. pressing
    • B29C59/026—Surface shaping of articles, e.g. embossing; Apparatus therefor by mechanical means, e.g. pressing of layered or coated substantially flat surfaces
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B26—HAND CUTTING TOOLS; CUTTING; SEVERING
    • B26D—CUTTING; DETAILS COMMON TO MACHINES FOR PERFORATING, PUNCHING, CUTTING-OUT, STAMPING-OUT OR SEVERING
    • B26D3/00—Cutting work characterised by the nature of the cut made; Apparatus therefor
    • B26D3/08—Making a superficial cut in the surface of the work without removal of material, e.g. scoring, incising
    • B26D3/085—On sheet material
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B26—HAND CUTTING TOOLS; CUTTING; SEVERING
    • B26D—CUTTING; DETAILS COMMON TO MACHINES FOR PERFORATING, PUNCHING, CUTTING-OUT, STAMPING-OUT OR SEVERING
    • B26D7/00—Details of apparatus for cutting, cutting-out, stamping-out, punching, perforating, or severing by means other than cutting
    • B26D7/08—Means for treating work or cutting member to facilitate cutting
    • B26D7/10—Means for treating work or cutting member to facilitate cutting by heating
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B26—HAND CUTTING TOOLS; CUTTING; SEVERING
    • B26F—PERFORATING; PUNCHING; CUTTING-OUT; STAMPING-OUT; SEVERING BY MEANS OTHER THAN CUTTING
    • B26F1/00—Perforating; Punching; Cutting-out; Stamping-out; Apparatus therefor
    • B26F1/18—Perforating by slitting, i.e. forming cuts closed at their ends without removal of material
    • B26F1/20—Perforating by slitting, i.e. forming cuts closed at their ends without removal of material with tools carried by a rotating drum or similar support
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B26—HAND CUTTING TOOLS; CUTTING; SEVERING
    • B26F—PERFORATING; PUNCHING; CUTTING-OUT; STAMPING-OUT; SEVERING BY MEANS OTHER THAN CUTTING
    • B26F1/00—Perforating; Punching; Cutting-out; Stamping-out; Apparatus therefor
    • B26F1/38—Cutting-out; Stamping-out
    • B26F1/384—Cutting-out; Stamping-out using rotating drums
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B29—WORKING OF PLASTICS; WORKING OF SUBSTANCES IN A PLASTIC STATE IN GENERAL
    • B29C—SHAPING OR JOINING OF PLASTICS; SHAPING OF MATERIAL IN A PLASTIC STATE, NOT OTHERWISE PROVIDED FOR; AFTER-TREATMENT OF THE SHAPED PRODUCTS, e.g. REPAIRING
    • B29C33/00—Moulds or cores; Details thereof or accessories therefor
    • B29C33/0033—Moulds or cores; Details thereof or accessories therefor constructed for making articles provided with holes
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B29—WORKING OF PLASTICS; WORKING OF SUBSTANCES IN A PLASTIC STATE IN GENERAL
    • B29C—SHAPING OR JOINING OF PLASTICS; SHAPING OF MATERIAL IN A PLASTIC STATE, NOT OTHERWISE PROVIDED FOR; AFTER-TREATMENT OF THE SHAPED PRODUCTS, e.g. REPAIRING
    • B29C33/00—Moulds or cores; Details thereof or accessories therefor
    • B29C33/38—Moulds or cores; Details thereof or accessories therefor characterised by the material or the manufacturing process
    • B29C33/40—Plastics, e.g. foam or rubber
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B29—WORKING OF PLASTICS; WORKING OF SUBSTANCES IN A PLASTIC STATE IN GENERAL
    • B29C—SHAPING OR JOINING OF PLASTICS; SHAPING OF MATERIAL IN A PLASTIC STATE, NOT OTHERWISE PROVIDED FOR; AFTER-TREATMENT OF THE SHAPED PRODUCTS, e.g. REPAIRING
    • B29C33/00—Moulds or cores; Details thereof or accessories therefor
    • B29C33/42—Moulds or cores; Details thereof or accessories therefor characterised by the shape of the moulding surface, e.g. ribs or grooves
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B29—WORKING OF PLASTICS; WORKING OF SUBSTANCES IN A PLASTIC STATE IN GENERAL
    • B29C—SHAPING OR JOINING OF PLASTICS; SHAPING OF MATERIAL IN A PLASTIC STATE, NOT OTHERWISE PROVIDED FOR; AFTER-TREATMENT OF THE SHAPED PRODUCTS, e.g. REPAIRING
    • B29C59/00—Surface shaping of articles, e.g. embossing; Apparatus therefor
    • B29C59/02—Surface shaping of articles, e.g. embossing; Apparatus therefor by mechanical means, e.g. pressing
    • B29C59/04—Surface shaping of articles, e.g. embossing; Apparatus therefor by mechanical means, e.g. pressing using rollers or endless belts
    • B29C59/046—Surface shaping of articles, e.g. embossing; Apparatus therefor by mechanical means, e.g. pressing using rollers or endless belts for layered or coated substantially flat surfaces
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M37/00—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin
    • A61M37/0015—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin by using microneedles
    • A61M2037/0053—Methods for producing microneedles
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B29—WORKING OF PLASTICS; WORKING OF SUBSTANCES IN A PLASTIC STATE IN GENERAL
    • B29C—SHAPING OR JOINING OF PLASTICS; SHAPING OF MATERIAL IN A PLASTIC STATE, NOT OTHERWISE PROVIDED FOR; AFTER-TREATMENT OF THE SHAPED PRODUCTS, e.g. REPAIRING
    • B29C2793/00—Shaping techniques involving a cutting or machining operation
    • B29C2793/0045—Perforating
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B29—WORKING OF PLASTICS; WORKING OF SUBSTANCES IN A PLASTIC STATE IN GENERAL
    • B29C—SHAPING OR JOINING OF PLASTICS; SHAPING OF MATERIAL IN A PLASTIC STATE, NOT OTHERWISE PROVIDED FOR; AFTER-TREATMENT OF THE SHAPED PRODUCTS, e.g. REPAIRING
    • B29C33/00—Moulds or cores; Details thereof or accessories therefor
    • B29C33/38—Moulds or cores; Details thereof or accessories therefor characterised by the material or the manufacturing process
    • B29C33/3842—Manufacturing moulds, e.g. shaping the mould surface by machining
    • B29C33/3857—Manufacturing moulds, e.g. shaping the mould surface by machining by making impressions of one or more parts of models, e.g. shaped articles and including possible subsequent assembly of the parts
    • B29C33/3878—Manufacturing moulds, e.g. shaping the mould surface by machining by making impressions of one or more parts of models, e.g. shaped articles and including possible subsequent assembly of the parts used as masters for making successive impressions

Definitions

  • the invention relates to a method for producing a shaped element for the production of microarrays. Furthermore, the invention relates to a shaped element for the production of microarrays, produced in particular with the method according to the invention.
  • Microarrays have a multiplicity of microneedles, which are usually arranged in or connected to a carrier element, such as in a patch, a plaster or the like. Microarrays have a large number of microneedles, the length of which is dimensioned such that when they are pressed into the skin of a patient, they penetrate the skin only far enough so that nerves and vessels are not touched by the needle tips as far as possible.
  • the needles contain an active substance, for example a drug.
  • the corresponding active substance can be applied to an upper side of the needle or can be arranged in the needles.
  • the needles or parts of the needles are made of a material that dissolves in the patient's skin.
  • Microarrays are produced, for example, with the aid of silicone molds, which have a large number of mold openings designed as depressions, which serve as negative molds.
  • a liquid provided with the active substance is usually applied to the upper side of the silicone matrix. After the liquid has dried, another liquid is applied if necessary.
  • the production of the silicone molds with their indentations is currently carried out, for example, by means of an injection molding process.
  • the object of the invention is to create a method for producing a shaped element for the production of microarrays, which is inexpensive and preferably suitable for the production of large quantities. Furthermore, it is the object of the invention to create a corresponding shaped element.
  • the object is achieved according to the invention by a method according to claim 1 or a shaped element according to claim 8.
  • the method according to the invention for producing a shaped element for the production of microarrays is, in particular, a method for producing an open shaped element, in particular open on both sides, for the production of microarrays.
  • a flat base element is provided.
  • the base member has a first surface and a second surface opposite the first surface.
  • the first surface is in particular the upper side of the base element, while the second surface is in particular the underside of the base element.
  • a further, second step consists in providing a flat auxiliary element on the second surface.
  • the step of providing the auxiliary element takes place before or after providing the base element, although it is particularly preferred that the auxiliary element is provided together with the base element.
  • the base element is penetrated, starting from the first surface, in order to form mold openings in the base element.
  • Penetration means in particular a complete penetration of the base element, so that the base element is completely penetrated.
  • the mold openings formed thereby preferably run from the first surface to the second surface, so that continuous openings are formed.
  • the auxiliary element there is also penetration into the auxiliary element. For example, if the base element is penetrated by a punching tool, the punching tool completely penetrates the base element and also penetrates into the auxiliary element. It is particularly preferred that partial penetration into the auxiliary element takes place. It is hereby preferred that the auxiliary element is not completely penetrated.
  • non-reversible means invasive penetration into the auxiliary element, so that the penetration results in an, in particular permanent, open depression in the auxiliary element.
  • the non-reversible penetration is therefore preferably a reshaping or separating penetration. If the penetration takes place, for example, by means of a punching tool, the base element is penetrated by the punching tool and the punching tool also partially penetrates into the auxiliary element, so that a partial opening occurs here as well.
  • reversible intrusion means, in other words, non-invasive intrusion.
  • the auxiliary element is deformed back at the point of penetration, in particular after it has been pushed out of the auxiliary element. In particular, no opening remains at the point where the auxiliary element has penetrated.
  • the auxiliary element is designed to be deformable and/or elastic, so that a resilience can take place via the elasticity.
  • Another preferred step after penetrating the base element and penetrating the auxiliary element consists in penetrating out of the base element and penetrating out of the auxiliary element.
  • the penetration into the base element and the auxiliary element takes place in particular together, preferably with the same tool. It is particularly preferred that the ejection from the base element and the auxiliary element takes place together. If, for example, penetration and penetration take place by means of a punching tool, penetration occurs when the punching tool is withdrawn. In particular, the mold openings run through the base element and partially into the auxiliary element.
  • the method according to the invention is advantageous compared to an alternative method for producing open structures, in which openings are produced in a laser process downstream of an injection molding process. Such a disadvantageous injection molding and laser process is very complicated and expensive.
  • the method according to the invention is inexpensive and preferably suitable for the production of large quantities the simplified process management and the combination of both processes, the production and opening of the mold openings, realized in one step.
  • the auxiliary element is connected to the base element.
  • the connection between the auxiliary element and the base element is preferably designed to be detachable. It is particularly preferred that the connection is adhesive, in particular releasably adhesive.
  • the planar auxiliary element is connected in particular with a planar side to the second surface of the base element. The detachable connection advantageously means that after the mold openings have been formed, the auxiliary element can be removed from the base element and the base element can thus be used as a mold device.
  • the base element and the auxiliary element are provided by jointly providing a composite element.
  • the composite element has the base element and the auxiliary element. It is particularly preferred that the composite element has a film composite, in particular consists of it.
  • the penetration is by embossing.
  • the embossing takes place here in particular with at least one, preferably a large number of embossing tools having complementary elevations to the mold openings. It is particularly preferred that the penetration takes place by hot embossing.
  • the embossing temperature is preferably 80° - 260° C.
  • the penetration in particular the embossing, takes place in particular continuously or discontinuously.
  • the same embossing tool is used for the penetration as well.
  • the auxiliary element makes it particularly advantageous for the embossing tool to be protected from damage and/or wear during embossing, since it is shielded when it penetrates the auxiliary element and is therefore not connected to other objects or the like. come into contact, which could lead to damage.
  • the penetration it is possible for the penetration to take place by means of drilling and/or milling and/or punching.
  • embossing it is preferred that this is done by means of an embossing roller. If, on the other hand, there is punching, it is preferred that this is done by means of a punching roller. It is also possible, for example, for embossing to take place using an embossing stamp or punching using a punch.
  • a further step takes place in particular: cooling.
  • At least one cooling of the base element preferably takes place.
  • Cooling of the auxiliary element also preferably takes place. Cooling to room temperature preferably takes place.
  • a further step of the method consists in removing the auxiliary element from the base element. Pulling off the auxiliary element from the base element is particularly preferred.
  • the step of removing the auxiliary member from the base member occurs after the penetrating step, but it is particularly preferred that the removing step occurs after cooling.
  • the shaped element according to the invention for the production of microarrays has a flat base element.
  • the base member has a first surface and a second surface opposite the first surface.
  • the first surface is preferably the top, while the second surface is preferably the bottom of the base member.
  • a flat auxiliary element is arranged on the side of the second surface of the base element.
  • the auxiliary element is preferably arranged on the second surface of the base element.
  • the auxiliary element is particularly preferably connected to the second surface of the base element.
  • the mold member has a plurality of mold openings extending from the first surface of the base member through the second surface of the base member. The mold openings thus run completely through the base element. In other words, the base element is thus continuously open on both sides. It is preferred that the mold openings are embossed mold openings. Both Mold openings are in particular negative molds for microarrays to be produced.
  • the mold openings partially extend into the auxiliary element. It is thus preferred that the mold openings run from the first surface of the base element into a part of the auxiliary element. In particular, the mold openings do not extend completely through the auxiliary element.
  • the auxiliary element is connected to the base element.
  • the connection between the auxiliary element and the base element is detachable. It is particularly preferred that the connection between the auxiliary element and the base element is adhesive, preferably detachable-adhesive.
  • the base element and/or the auxiliary element has, in particular, consists of thermoplastic and/or thermoplastic elastomer.
  • the base element and/or the auxiliary element particularly preferably has TPU, PC, APET, PPC and/or PETG, and in particular consists of them.
  • the base element and/or the auxiliary element has a film, in particular consists of it.
  • the film preferably has a thickness of 0.2-2.0 mm, particularly preferably 0.5-1.5 mm. It is particularly preferred that the base element has a film with a thickness of 0.5-1.5 mm and/or the auxiliary element has a film with a thickness of 0.1-2 mm.
  • the mold openings are cylindrical or conical. If, for example, the mold openings are formed by embossing, it is preferable for the embossing tool to have one or more cylindrical or conical elevations that are complementary to the cylindrical or conical mold openings.
  • the mold openings preferably correspond to negative molds of the microarrays to be produced. It is preferred that the base of the cylindrical or conical mold opening is on the first surface of the base member. In particular, the base of the cylindrical or conical mold opening is a circle, an oval, a rectangle or a square. If the mold openings are conical, they can also be truncated cones.
  • the cross section of the mold openings preferably tapers from the top of the base element towards the bottom.
  • the mold openings are preferably symmetrical in the longitudinal direction, in particular rotationally symmetrical, so that the opening provided on the underside is arranged centrally in relation to a base area of the mold opening
  • the auxiliary element in particular the material from which the auxiliary element is made, has a higher hot forming temperature than the base element, in particular than the material from which the base element is made.
  • the auxiliary element preferably has a higher melting temperature than the base element. It is preferred that the auxiliary element has a substantially higher hot forming temperature than the base element.
  • the auxiliary element preferably has a higher elasticity than the base element. In particular, the auxiliary element has a smaller modulus of elasticity than the base element.
  • the auxiliary element can have a porous structure, for example. It is possible that the auxiliary element has one or more of the features described in this paragraph.
  • Each individual mold opening on the first surface preferably has a cross-sectional area of 0.04 mm 2 - 0.16 mm 2 , in particular 0.04 - 0.08 mm 2 .
  • the mold openings themselves preferably have a depth of 600 ⁇ m to 2200 ⁇ m, in particular 600 ⁇ m to 1000 ⁇ m. It is preferred that the mold openings extend through the entire thickness of the base element.
  • the mold openings extend into the auxiliary element with a depth of 10 ⁇ m to 500 ⁇ m, preferably with a depth of 50 ⁇ m to 300 ⁇ m, particularly preferably with a maximum depth of 80 ⁇ m.
  • the base element which is designed in particular as a film, preferably has a thickness of 500 ⁇ m-1.5 mm.
  • the auxiliary element which is designed in particular as a film, preferably has a thickness of 100 ⁇ m ⁇ 2 mm.
  • the mold openings on the second surface of the base member and / or the Openings on the auxiliary element preferably have a cross-sectional area of ⁇ 1200 ⁇ m 2 , in particular ⁇ 100 ⁇ m 2 .
  • the shaped openings on the second surface of the base element and/or the openings on the auxiliary element preferably have a diameter of ⁇ 40 ⁇ m, in particular ⁇ 10 ⁇ m.
  • the preferred composite element which has at least the base element and the auxiliary element and which is designed in particular as a film composite, preferably has a thickness of 600 ⁇ m to 3.5 mm.
  • the auxiliary element can be at least partially detached from the base element, in particular can be pulled off. It is possible for the auxiliary element to be present at least partially detached from the base element, in particular pulled off.
  • the method according to the invention described above can preferably be supplemented by one or more features of the shaped element according to the invention described above.
  • the shaped element according to the invention described above can preferably be supplemented by one or more features of the method according to the invention described above.
  • FIG. 1 shows a schematic side view of a composite element with a base element and an auxiliary element
  • FIG. 2 shows a schematic side view of a composite element together with an embossing roller
  • Fig. 3 shows a schematic side view of an embossed composite element
  • FIG. 4 shows a schematic detailed view of the section from FIG. 3 with a mold opening produced by the method according to the invention
  • FIG. 5 shows a schematic side view of another composite element together with an embossing roller
  • FIG. 6 shows a schematic side view of another composite element together with an embossing roller.
  • the composite element 13 has a base element 10 and an auxiliary element 11 .
  • the base element 10 and the auxiliary element 11 are films, so that the composite element 13 corresponds to a film composite.
  • the base element 10 and the auxiliary element 11 are shown provided, with the provision being shown here by feeding from the left.
  • a second surface side 24 of the base element 10 is adhesively bonded to a first surface 40 to form the composite element 13 .
  • the adhesive connection takes place in particular by means of adhesive, which is arranged, for example, on the first surface 40 of the auxiliary element 11 and/or on the second surface of the base element 10.
  • the adhesive can be an adhesive layer that is connected to the first surface 40 of the auxiliary element and/or to the second surface 24 of the base element 10 .
  • the first surface 16 of the base element 10 is located opposite the second surface 24 of the base element 10.
  • the second surface 42 of the auxiliary element 11 is located opposite the first surface 40 of the auxiliary element 11.
  • the first surface is preferably an upper side and/or or, in the case of the second surface, an underside.
  • a composite element 13 in particular in the form of a film composite is moved from the left (arrow 44) in the direction of arrow 12 in the exemplary embodiment shown in FIG.
  • the composite element 13 shown in FIG. 2 is preferably the composite element 13 from FIG. 1.
  • an embossing roller is preferably provided, which rotates in the direction of an arrow 20, counterclockwise in the exemplary embodiment.
  • a large number of elevations 22 are provided on an outside of the embossing roller 18 .
  • Regularly recurring areas of the outside of the embossing roller are provided with elevations 22 .
  • elevations 22 it is possible for elevations 22 to be distributed regularly over the entire outside of the embossing roller 18 .
  • the cross section of the elevations 22 shown corresponds to the cross section of the mold openings 14 .
  • the mold openings 14 shown here extend completely through the base element 10 and continue further into a part of the auxiliary element 11 .
  • the part of the mold opening 14 that extends through the base element 10 corresponds to a base mold opening 15, which is preferably used later as a matrix used to produce the microarrays.
  • the part of the mold opening 14 in the auxiliary element 11 represents an auxiliary opening 17 in this case.
  • the elevations 22 are, in particular, configured in the shape of a pyramid and have a cross-section that is preferably square or round.
  • FIG. 3 shows an exemplary embodiment of a shaped element 100 according to the invention, which was preferably produced using an embodiment of the method according to the invention. It is preferred that the shaped element 100 from FIG. 3 is the shaped element 100 from FIG. 2 . The shaped element 100 is fed in from the left in the direction of the arrow 12 .
  • the shaped element 100 has areas 102 , 102 ′ with embossed shaped openings 14 and region 104 without embossed shaped openings 14 .
  • the auxiliary element 11' is removed, in particular pulled off, from the base element 10' in the direction of the arrow 108.
  • the base element 10' which is continued in the direction of the arrow 106, thus has the base mold openings 15 on, while the removed auxiliary element 11 'has the auxiliary depressions 17.
  • the base element 10' with base mold openings 15 and the auxiliary element 11' removed therefrom with auxiliary depressions 17 form the mold element 10'.
  • the shaped element 100 shown thus corresponds to a first exemplary embodiment of a shaped element according to the invention, for example a shaped element with a partially removed auxiliary element 11'.
  • the molded element 100' also shown corresponds to a second exemplary embodiment of a molded element to be produced, for example a molded element with a connected auxiliary element 11.
  • the molded element 100" also shown corresponds to a third exemplary embodiment of a molded element to be produced, for example a molded element with the auxiliary element 11' completely removed these different versions of the shaped element in particular to different states and/or areas of a shaped element to be produced according to the invention.
  • the embodiment from Fig. 5 essentially corresponds to that from Fig. 2.
  • the auxiliary element 11 in Fig. 6 has a high elasticity and/or a high embossing temperature, so that after the penetration of the elevations 22 into the auxiliary element 11, no auxiliary depressions 17 (see FIG. 2) remain in the auxiliary element 11, but the auxiliary element 11 preferably returns to its original shape.
  • the mold openings 14 according to the exemplary embodiment from FIG Base mold openings 15.

Landscapes

  • Engineering & Computer Science (AREA)
  • Mechanical Engineering (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Forests & Forestry (AREA)
  • Manufacturing & Machinery (AREA)
  • Physics & Mathematics (AREA)
  • Optics & Photonics (AREA)
  • Moulds For Moulding Plastics Or The Like (AREA)
  • Shaping Of Tube Ends By Bending Or Straightening (AREA)

Abstract

La présente invention concerne un procédé de production d'un élément de moule (100) permettant la production de microréseaux, comprenant les étapes consistant : (i) à fournir un élément de base (10) plat qui présente une première surface (16) et une seconde surface (24) reposant opposée à la première surface (16), (ii) à fournir un élément auxiliaire (11) plat sur la seconde surface (24), (iii) à percer l'élément de base (10) en commençant depuis la première surface (40) afin de former des ouvertures de moule (14), et (iv) à percer, de manière réversible ou non réversible, l'élément auxiliaire (11) à l'issue du perçage de l'élément de base (10). L'invention concerne additionnellement un élément de moule (100) pour produire des microréseaux, comprenant un élément de base (10) plat qui présente une première surface (16) et une seconde surface (24) reposant opposée à la première surface (16), un élément auxiliaire (11) plat qui est disposé sur la seconde surface (16), et de multiples ouvertures de moule (14) qui s'étendent depuis la première surface (16) de l'élément de base (10) vers la seconde surface de l'élément de base (10).
EP22702399.1A 2021-02-04 2022-01-13 Procédé de production d'un élément de moule permettant la production de microréseaux, et élément de moule Pending EP4288262A1 (fr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE102021102555.9A DE102021102555A1 (de) 2021-02-04 2021-02-04 Verfahren zur Herstellung eines Formelements für die Herstellung von Mikroarrays sowie Formelement
PCT/EP2022/050670 WO2022167191A1 (fr) 2021-02-04 2022-01-13 Procédé de production d'un élément de moule permettant la production de microréseaux, et élément de moule

Publications (1)

Publication Number Publication Date
EP4288262A1 true EP4288262A1 (fr) 2023-12-13

Family

ID=80225933

Family Applications (1)

Application Number Title Priority Date Filing Date
EP22702399.1A Pending EP4288262A1 (fr) 2021-02-04 2022-01-13 Procédé de production d'un élément de moule permettant la production de microréseaux, et élément de moule

Country Status (7)

Country Link
US (1) US20240083078A1 (fr)
EP (1) EP4288262A1 (fr)
JP (1) JP2024506881A (fr)
CN (1) CN116802036A (fr)
CA (1) CA3206954A1 (fr)
DE (1) DE102021102555A1 (fr)
WO (1) WO2022167191A1 (fr)

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3634016A1 (de) 1986-04-17 1987-10-29 Lohmann Gmbh & Co Kg Flaechenfoermiges therapeutisches system, verfahren zu seiner herstellung und seine verwendung
SE508040C2 (sv) * 1994-11-09 1998-08-17 Moelnlycke Ab Yttre skikt för en absorberande artikel samt metodför dess tillverkning
EP1740256A4 (fr) * 2003-11-10 2011-06-29 Agency Science Tech & Res Micro-aiguilles et fabrication de micro-aiguilles
WO2005087305A1 (fr) * 2004-03-12 2005-09-22 Agency For Science, Technology And Research Procedes et moules s'utilisant dans la fabrication de micro-aiguilles a orifice lateral
JP5152935B2 (ja) 2010-04-28 2013-02-27 株式会社日本製鋼所 貫通孔を有する微細構造成形体の製造方法及び微細構造成形体素材

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US20240083078A1 (en) 2024-03-14
CA3206954A1 (fr) 2022-08-11
CN116802036A (zh) 2023-09-22

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