EP3972681A1 - Dispositif d'injection de substances dans la peau - Google Patents

Dispositif d'injection de substances dans la peau

Info

Publication number
EP3972681A1
EP3972681A1 EP20732733.9A EP20732733A EP3972681A1 EP 3972681 A1 EP3972681 A1 EP 3972681A1 EP 20732733 A EP20732733 A EP 20732733A EP 3972681 A1 EP3972681 A1 EP 3972681A1
Authority
EP
European Patent Office
Prior art keywords
skin
injection needle
negative pressure
substance
epidermis
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Withdrawn
Application number
EP20732733.9A
Other languages
German (de)
English (en)
Inventor
René LA FONTAINE
Robert Wilhelm SCHMIDT
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Individual
Original Assignee
Individual
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Individual filed Critical Individual
Publication of EP3972681A1 publication Critical patent/EP3972681A1/fr
Withdrawn legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M37/00—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin
    • A61M37/0076—Tattooing apparatus
    • A61M37/0084—Tattooing apparatus with incorporated liquid feeding device
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/42—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests having means for desensitising skin, for protruding skin to facilitate piercing, or for locating point where body is to be pierced
    • A61M5/425—Protruding skin to facilitate piercing, e.g. vacuum cylinders, vein immobilising means

Definitions

  • the present invention relates to a device for injecting substances into the skin, especially under the epidermis.
  • the human skin is divided into three layers, the epidermis or
  • Epidermis Epidermis, the dermis or dermis and the subcutis or subcutaneous tissue.
  • the epidermis is characterized by continuous renewal, with dead skin cells falling off the surface and new skin cells being replicated in the lower area.
  • permanent pigmentation cannot occur in the epidermis.
  • the blood vessels run in the subcutis so that substances introduced there are transported away comparatively quickly. Consequently, tattoos and permanent make-up should be applied to the dermis in order to achieve the desired durability.
  • the active ingredients are conventionally injected using needles.
  • the variance in the puncture depth is just as disadvantageous here.
  • the active ingredients are only dosed imprecisely in large-area treatments.
  • Treatment is often painful and takes a long time.
  • the aim is to inject the substances under the epidermis in a skin-friendly and sterile manner, without the risk of contamination.
  • the device according to the invention comprises an injection needle and a
  • Vacuum generator that sucks in the skin and applies it to an inwardly curved system from which the injection needle protrudes.
  • the penetration depth is thus determined by the length with which the injection needle protrudes from the surface of the system, regardless of the nature of the skin and other influencing variables.
  • the system has an inwardly curved surface so that the
  • Injection needle does not protrude over the edge and the edge of the system can rest on the skin.
  • the injection needle can comprise one, two, three or even more cannulas.
  • the cannula (s) is (are) expediently connected to a substance chamber which contains a supply of the substance to be injected, preferably via a metering device.
  • a piezo element, with which the volume of the substance chamber can be changed, is preferred as the metering device.
  • the negative pressure generator is designed such that it can provide a negative pressure in the range from 100 to 800 mbar, preferably from 100 to 400 mbar.
  • the negative pressure can expediently be regulated, so that the skin is safely sucked in and applied to the system without an unnecessarily high negative pressure having to be generated.
  • the skin is tightened by about 0.5 mm, with an opening of 2.8 mm and a negative pressure of 700 mbar about 0.75 mm.
  • a motor-driven piston is provided as the vacuum generator, the vacuum being able to be regulated via the stroke of the piston.
  • a vacuum pump preferably with a vacuum container.
  • the vacuum generator is formed by a valve which can either release a vacuum supply channel or open an atmospheric pressure equalization via a ventilation channel.
  • the device according to the invention usually comprises a handpiece in which the injection needle and the system are located within a housing are arranged.
  • the vacuum generator and / or the substance chamber, if necessary with a metering valve, can also be contained in the handpiece.
  • a vacuum pump or an electric drive for a piston as a vacuum generator are expediently housed in a separate housing so that the handpiece does not become too heavy or too large.
  • a disposable plastic applicator which is usually packaged sterile until it is used, is preferred as the injection needle.
  • Embodiment a new applicator is used for each treatment.
  • the system is preferably designed as an integral part of the applicator.
  • the disposable applicator with a housing part that the
  • Vacuum generator includes, are coupled to the handpiece by connecting elements. Suitable are e.g. Thread or detent, the seal is usually made by O-rings.
  • the injection needle is also possible to configure only the injection needle as a disposable item. This is then fixed in the handpiece after removal from the usual sterile packaging, e.g. screwed in.
  • the system forms part of the handpiece. Because it has a smooth surface, it is easy to clean and sterilize.
  • the handpiece can be made in two parts, so that the front part can be easily cleaned and sterilized.
  • the substance to be injected can be any liquid known per se and intended for injection under the skin, e.g. about tattoo inks, permanent make-up, cosmetic ingredients and pharmaceuticals.
  • the device according to the invention is a considerable advance, particularly for tattooing, since a uniform penetration depth is achieved regardless of a locally different resistance of the skin to piercing. This prevents a painful piercing that is too deep. But at the same time also ensures reliable injection of the ink into the dermis. Active dosing makes the image sharper and more permanent, as the intended amount of paint is applied. The same applies to permanent make-up.
  • hyaluronic acid for wrinkle treatment and caffeine should be considered.
  • caffeine for cosmetic active ingredients, for example, hyaluronic acid for wrinkle treatment and caffeine should be considered.
  • pharmaceuticals e.g.
  • the inventive method for tattooing, applying permanent make-up or injecting cosmetic active ingredients provides that a device according to the invention is guided over the skin in such a way that the edge of the system, e.g. the opening of the disposable applicator that touches the skin area to be treated.
  • the shape of the system is designed in such a way that when the negative pressure is generated, the upper layers of skin are sucked in and applied to the surface of the system.
  • the epidermis is penetrated by the injection needle protruding from the system with a defined penetration depth. Once this process is complete, the substance is injected.
  • this is done by activating a piezo element which reduces the volume of the substance chamber. This results in an increase in pressure and a defined amount of substance is transported precisely under the epidermis through the injection needle.
  • the activation of the piezo element can be repeated several times within a fraction of a second when the injection needle has penetrated.
  • Piezo element can also determine the extent of the change in volume in the substance chamber. This enables precise dosing of the substance.
  • the device can then be moved and placed again.
  • the entire process is repeated until the intended area has been treated.
  • the entire process can take place several times within a second and thus enables the applicator to move in contact with and parallel to the skin surface.
  • the repetition frequency of the entire process is determined by the set pulsating vacuum and, if necessary, the set
  • the amplitude and the frequency of the negative pressure and the overpressure in the reservoir can be set independently of one another, and thus the dosage of the substance can be precisely defined.
  • the penetration depth can be determined via the shape of the system or an adjustment of the length with which the injection needle protrudes from the surface of the system.
  • the definability of the two parameters penetration depth and dosage enables a better treatment result with less substance consumption and less damage to the skin.
  • the invention also relates to all combinations of preferred
  • Figure 1 shows a preferred embodiment of a device according to the invention in section
  • FIGS. 2a-2g show the device from FIG. 1 in different stages of the process
  • FIG. 3 shows an alternative embodiment of the device
  • FIGS. 4a-4c show a further alternative embodiment of the device.
  • the device in FIG. 1 comprises a piston 1 driven by an electric motor as a vacuum generator which is arranged in a housing 2. If the piston 1 is in a deflected position, as shown in FIG. 1, then there is a negative pressure in region 3. The negative pressure acts on the system 5 via the connection 4 sealed with an O-ring. As a result, the sludge 6 is sucked in and applied to the system 5.
  • the disposable applicator 7 with the injection needle 8 is also coupled to the housing 2 via a connection 9 sealed with an O-ring.
  • a piezo element 10 is connected to the substance chamber 11 and is used to dose the substance 12 to be injected, of which an additional supply is contained in a storage container 13 within the housing 2.
  • the piezo element 10 is actuated and thus the volume of the substance chamber 11 scaled down.
  • substance 12 is pressed through the cannula (s) of injection needle 8 into the dermis. This can be repeated several times.
  • the negative pressure is released by moving the piston 1 back. Due to its elasticity, the skin 6 detaches itself from the system 5 and the injection needle 8. The device can now be repositioned.
  • FIGS. 2a to 2g The sequence of the method is illustrated in FIGS. 2a to 2g with the aid of the device shown in FIG.
  • the handpiece is first positioned at the desired location, with no negative pressure prevailing.
  • negative pressure is generated by moving the piston 1 in the area 3, so that the skin 6, as shown in FIG. 2c, rests against the system 5 when the maximum deflection of the piston 1 is reached.
  • the needle 8 pierces the skin 6.
  • FIG. 2 d the piezo element 10 has been actuated, as a result of which it reduces the volume of the substance chamber 11 and opens the way to the needle 8. Substance 12 is thus injected into skin 6 through needle 8.
  • the piezo element has returned to its currentless form, while the path to the needle 8 is closed and 11 substance 12 is sucked out of the reservoir 13 by the volume increase of the substance chamber.
  • the steps in Figures 2d and 2e are repeated if desired until the required amount
  • FIG. 3 shows an alternative device in which a continuous negative pressure is generated by a vacuum pump. Identical parts are denoted by the same reference numerals as in FIG. In the design in FIG. 3, a two-part housing 2, 2 'is used, which has power lines 14 and the upper part of which has a supply line 15 for the negative pressure generated by a vacuum pump (not shown).
  • the housing parts 2 and 2 ' are detachably connected by means of a click connection 16, the sealing takes place via O-ring seals 9.
  • a foreign matter filter 17 is installed at the upper end of the area with negative pressure in the lower housing part 2' to protect against contamination and germs.
  • the negative pressure is controlled here with the aid of a piezo element 18 which actuates a valve 19 which opens or closes a ventilation channel 20.
  • Substance chamber 11 with the aid of a piezo element 10 and the injection needle 8.
  • the storage container 13 can be filled with substance via the refilling point 21.
  • Disposable needles 8 are generally used in this design.
  • the entire housing part 2 ' can be provided as a disposable item.
  • the structure and mode of operation remain in principle similar to the previous variants.
  • the substances are injected without valves.
  • the slack is sucked in by a vacuum system.
  • the substance is dosed by piezo elements 10.
  • An electrical voltage causes the piezo elements 10 to expand vertically.
  • the level of voltage determines the extent of expansion.
  • the frequency of the voltage (change between a positive and negative voltage) determines the

Landscapes

  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Dermatology (AREA)
  • Medical Informatics (AREA)
  • Anesthesiology (AREA)
  • Virology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Hematology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Infusion, Injection, And Reservoir Apparatuses (AREA)

Abstract

L'invention concerne un dispositif pour injecter des substances (12) sous l'épiderme d'une peau (6), comprenant un générateur de dépression (1), une aiguille d'injection (8) fixe et une butée (5) contre laquelle la peau (6) est aspirée et appliquée par la dépression générée. La butée (5) est courbée vers l'intérieur, de sorte qu'un rebord est formé, et l'aiguille d'injection (8) fait saillie de la surface incurvée vers l'intérieur de la butée (5), mais ne dépasse pas au-dessus du rebord. L'invention concerne également un procédé d'injection d'encre de tatouage, de maquillage permanent ou de principes actifs cosmétiques sous l'épiderme d'une peau (6) au moyen du dispositif, comprenant les étapes suivantes : application du dispositif sur la peau (6) ; génération d'une dépression avec le générateur de dépression (1) de sorte que la peau (6) soit appliquée contre la butée (5), l'épiderme étant transpercé par l'aiguille d'injection (8) ; injection de la substance (12) sous l'épiderme ; annulation de la dépression.
EP20732733.9A 2019-05-21 2020-05-19 Dispositif d'injection de substances dans la peau Withdrawn EP3972681A1 (fr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE102019113571.0A DE102019113571A1 (de) 2019-05-21 2019-05-21 Vorrichtung zum Injizieren von Stoffen in die Haut
PCT/EP2020/063937 WO2020234284A1 (fr) 2019-05-21 2020-05-19 Dispositif d'injection de substances dans la peau

Publications (1)

Publication Number Publication Date
EP3972681A1 true EP3972681A1 (fr) 2022-03-30

Family

ID=71094261

Family Applications (1)

Application Number Title Priority Date Filing Date
EP20732733.9A Withdrawn EP3972681A1 (fr) 2019-05-21 2020-05-19 Dispositif d'injection de substances dans la peau

Country Status (3)

Country Link
EP (1) EP3972681A1 (fr)
DE (1) DE102019113571A1 (fr)
WO (1) WO2020234284A1 (fr)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN114247047B (zh) * 2021-12-17 2023-05-23 广东工业大学 一种基于压电驱动柔顺机构的微创皮肤着色装置
DE102022110101A1 (de) 2022-04-22 2023-10-26 Ionto Health & Beauty Gmbh Hautbehandlungsgerät für die kosmetische Behandlung der menschlichen Gesichtshaut mittels Micro-Needling
CN115154880A (zh) * 2022-06-24 2022-10-11 济南国科医工科技发展有限公司 一种无回液水光针负压结构
CN116139366A (zh) * 2022-12-07 2023-05-23 华熙生物科技股份有限公司 一种水光注射针

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6896666B2 (en) * 2002-11-08 2005-05-24 Kochamba Family Trust Cutaneous injection delivery under suction
AU2004251699A1 (en) * 2003-06-04 2005-01-06 Georgia Tech Research Corporation Drilling microneedle device
US20070270745A1 (en) * 2006-05-18 2007-11-22 Camran Nezhat Vacuum actuated tissue lifting device
PL2682146T3 (pl) * 2012-07-05 2017-04-28 Mt Derm Gmbh Przyrząd ręczny do tatuowania lub nanoszenia makijażu permanentnego oraz moduł igłowy z regulowaną głębokością wkłuwania
US10695509B2 (en) * 2015-11-28 2020-06-30 Biopreme Medical Technologies Inc. Negative pressure injection device

Also Published As

Publication number Publication date
WO2020234284A1 (fr) 2020-11-26
DE102019113571A1 (de) 2020-11-26

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