EP3964292A1 - Geschlossene einheit zur verarbeitung biologischer proben und verwendungen davon - Google Patents

Geschlossene einheit zur verarbeitung biologischer proben und verwendungen davon Download PDF

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Publication number
EP3964292A1
EP3964292A1 EP20305989.4A EP20305989A EP3964292A1 EP 3964292 A1 EP3964292 A1 EP 3964292A1 EP 20305989 A EP20305989 A EP 20305989A EP 3964292 A1 EP3964292 A1 EP 3964292A1
Authority
EP
European Patent Office
Prior art keywords
reaction tube
support
biological sample
guide means
housing
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
EP20305989.4A
Other languages
English (en)
French (fr)
Inventor
Clarence Deffaud
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Interhealth
Original Assignee
Interhealth
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Interhealth filed Critical Interhealth
Priority to EP20305989.4A priority Critical patent/EP3964292A1/de
Publication of EP3964292A1 publication Critical patent/EP3964292A1/de
Pending legal-status Critical Current

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Classifications

    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
    • B01L3/50—Containers for the purpose of retaining a material to be analysed, e.g. test tubes
    • B01L3/508—Containers for the purpose of retaining a material to be analysed, e.g. test tubes rigid containers not provided for above
    • B01L3/5085—Containers for the purpose of retaining a material to be analysed, e.g. test tubes rigid containers not provided for above for multiple samples, e.g. microtitration plates
    • B01L3/50853—Containers for the purpose of retaining a material to be analysed, e.g. test tubes rigid containers not provided for above for multiple samples, e.g. microtitration plates with covers or lids
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
    • B01L3/50—Containers for the purpose of retaining a material to be analysed, e.g. test tubes
    • B01L3/508—Containers for the purpose of retaining a material to be analysed, e.g. test tubes rigid containers not provided for above
    • B01L3/5085—Containers for the purpose of retaining a material to be analysed, e.g. test tubes rigid containers not provided for above for multiple samples, e.g. microtitration plates
    • B01L3/50855—Containers for the purpose of retaining a material to be analysed, e.g. test tubes rigid containers not provided for above for multiple samples, e.g. microtitration plates using modular assemblies of strips or of individual wells
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
    • B01L3/52—Containers specially adapted for storing or dispensing a reagent
    • B01L3/523—Containers specially adapted for storing or dispensing a reagent with means for closing or opening
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2200/00—Solutions for specific problems relating to chemical or physical laboratory apparatus
    • B01L2200/02—Adapting objects or devices to another
    • B01L2200/025—Align devices or objects to ensure defined positions relative to each other
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2200/00—Solutions for specific problems relating to chemical or physical laboratory apparatus
    • B01L2200/10—Integrating sample preparation and analysis in single entity, e.g. lab-on-a-chip concept
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2200/00—Solutions for specific problems relating to chemical or physical laboratory apparatus
    • B01L2200/14—Process control and prevention of errors
    • B01L2200/141—Preventing contamination, tampering
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2200/00—Solutions for specific problems relating to chemical or physical laboratory apparatus
    • B01L2200/16—Reagents, handling or storing thereof
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00—Additional constructional details
    • B01L2300/04—Closures and closing means
    • B01L2300/041—Connecting closures to device or container
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00—Additional constructional details
    • B01L2300/04—Closures and closing means
    • B01L2300/041—Connecting closures to device or container
    • B01L2300/042—Caps; Plugs
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00—Additional constructional details
    • B01L2300/04—Closures and closing means
    • B01L2300/041—Connecting closures to device or container
    • B01L2300/045—Connecting closures to device or container whereby the whole cover is slidable
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00—Additional constructional details
    • B01L2300/04—Closures and closing means
    • B01L2300/046—Function or devices integrated in the closure
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00—Additional constructional details
    • B01L2300/06—Auxiliary integrated devices, integrated components
    • B01L2300/0609—Holders integrated in container to position an object
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00—Additional constructional details
    • B01L2300/08—Geometry, shape and general structure
    • B01L2300/0809—Geometry, shape and general structure rectangular shaped
    • B01L2300/0825—Test strips
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2400/00—Moving or stopping fluids
    • B01L2400/06—Valves, specific forms thereof
    • B01L2400/0633—Valves, specific forms thereof with moving parts
    • B01L2400/0644—Valves, specific forms thereof with moving parts rotary valves
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
    • B01L3/56—Labware specially adapted for transferring fluids
    • B01L3/563—Joints or fittings ; Separable fluid transfer means to transfer fluids between at least two containers, e.g. connectors
    • B01L3/5635—Joints or fittings ; Separable fluid transfer means to transfer fluids between at least two containers, e.g. connectors connecting two containers face to face, e.g. comprising a filter

Definitions

  • the invention relates to a totally enclosed unit for biological sample processing, such as nucleic acid detection using nucleic acid thin-layer chromatography (test strip) technique, and to a method implementing biological sample processing in a totally enclosed detection unit.
  • Nucleic acid testing has been increasingly developed in the field of screening and diagnosis of infectious diseases and genetic disorders.
  • Nucleic acid testing assays comprises three main steps, consisting of extraction of nucleic acid, genome amplification, and amplicon detection.
  • Polymerase Chain Reaction (PCR) is a highly efficient technique for in vitro amplification of specific nucleic acid fragments by using the principle of denaturation and renaturation of nucleic acid in the presence of in vitro polymerases. For example, PCR detection of various pathogens has become one of the most important means for diagnosis of infectious diseases.
  • LAMP Loop-mediated isothermal amplification
  • the enclosed unit of the present invention comprising several (e.g. two or more) housings for receiving each a reaction tube containing a biological sample to process, the displacement of the guide means allowing to pull the protruding plugs of each reaction tubes placed in the housings of the support and to fall a corresponding reagent into each reaction tube. Accordingly, several biological sample processing may be carried out simultaneously.
  • the enclosed unit further comprises a protective cap mounted rotatably on the support, said protective cap comprising at least one chamber for receiving the reagent, and the guide means are fixed within an inner volume of said protective cap, said guide means comprising at least one set of holes comprising a first hole for receiving a protruding plug of a reaction tube placed in the housing of the support and a second hole for a reagent.
  • the support further comprises at least one housing for a protruding plug that closes an opened end of the chamber, the second hole of at least one set of holes on the guide means receiving and pulling out said protruding plug.
  • the support comprises a top part with at least one chamber for receiving a reagent and a base part with at least one housing for receiving a reaction tube, at least one chamber for the reagent being disposed substantially above at least one housing for a reaction tube, and the guide means extend transversally between the top part and the base part of the support, said guide means being mounted slidably with respect to said top part and base part of the support.
  • the inventors have developed a totally enclosed unit, wherein at least one biological sample to process can be brought into communication with a reagent without potentially contaminant manipulations.
  • a reagent refers to a substance, compound or product to be added to the biological sample to test if a reaction occurs, e.g. by revealing the presence of a target compound.
  • the reagents may be used in a chemical reaction to detect, measure or make other substances.
  • the reagent is a chromogenic reagent that reacts with specific chemical groups in the biological sample with the formation of a colored compound in situ.
  • the reagent is preferably in lyophilized or solid form.
  • the reagent may be a test strip, i.e. a band, piece or strip of paper or other material used for biological testing.
  • the enclosed unit of the present invention in use, is advantageously sealed from the external environment.
  • processing a biological sample may be carried out with low risk of contamination from the environment or to the environment.
  • the enclosed unit of the present invention may be used for processing any biological sample, particularly liquid sample such as saliva, blood, urine, cell suspension, etc.
  • the enclosed unit of the present invention is dedicated to be used for on-site nucleic acid testing.
  • a liquid sample is processed by a number of steps to amplify the nucleic acid, after which the processed sample is tested for the presence of a target nucleic acid by use of a test strip (i.e. reagent).
  • a test strip i.e. reagent
  • the guide means are movable relative to the housing receiving the reaction tube.
  • the displacement of the guide means allows the opening of the reaction tube and the reagent to be in overlapping relationship with the opened reaction tube.
  • the reagent is introduced in the reaction tube under influence of gravity.
  • the reagent In the position where the reagent is not in overlapping relationship with the opened reaction tube, the reagent is maintained within its chamber by a barrier, which is removed or displaced when the guide means are displaced. Gravity can act on the reagent when the barrier is displaced and the guide means are held in an appropriate position with respect to the reaction tube. Thereby, the reagent falls within the reaction tube and contacts the biological sample.
  • the reagent is a test strip.
  • the test strip is maintained substantially vertically with respect of the support and the reaction tube.
  • the test strip is housed in a similarly-dimensioned chamber in the protective cap or the top part of the support. If need be, retention means are provided in the chamber or on the guide means to maintain the test strip vertically.
  • the guide means are movable in translation with respect to the support. In another embodiment, the guide means are movable in rotation with respect to the support.
  • the guide means comprise access means which can open into or be aligned with the opened reaction tube for providing access of the reagent to the reaction tube.
  • the unit comprises sealing means for sealing the entire unit from the external environment.
  • sealing means may help prevent contamination of the sample during processing.
  • the inner volume of the support is sealed from the external environment, i.e. the unit provides a closed system and the sample cannot escape from the unit.
  • Such closed unit helps eliminate contamination from external sources, and at the same time protects the external environment from contamination with the processed biological sample. This is particularly important when processing involves the amplification of nucleic acid.
  • the sealing means may comprise any suitable means for sealing the support from the external environment while still allowing reagent to access to the reaction tube. Sealing may be achieved by the abutment of the guide means with respect to the support. In particular, the displacement of the guide means with respect to the support from an opened position to a closed position isolates an inner volume of the support from external environment.
  • the wall of the chamber receiving the test strip may be substantially transparent so that the result of the analysis can be seen without any need to open the unit.
  • the enclosed unit comprises several housings for receiving several reaction tubes
  • the guide means comprise several sets of holes, which can each open into or be aligned with a reaction tube for providing access of a reagent to said reaction tube.
  • the invention further provides a kit comprising an enclosed unit as exposed above and one or more reagents, particularly one or more test strips.
  • FIG. 1A A first embodiment is illustrated by figures 1A, 1B , 2A, 2B and 3A, 3B , wherein same references are used to designate same elements.
  • an enclosed unit 1 for biological sample processing comprises a support 2 comprising a housing 5 for receiving a reaction tube 3.
  • the housing 5 is formed integrally within the support 2.
  • the reaction tube 3 may be closed by a protruding plug 4.
  • the enclosed unit 1 further comprises a protective cap 6, mounted rotatably on the support 2.
  • the protective cap 6 comprises a chamber 7 for receiving a test strip 8 (i.e. reagent).
  • the chamber 7 has an opening 14 at an end, or extremity, of said chamber located outside the protective cap 6. Accordingly, the test strip 8 may be loaded in the chamber 7 at any time, by said opening 14, which is advantageously closable by a plug 9.
  • the extremity of the chamber 7 located outside the protective cap 6 is closed.
  • the chamber 7 comprises an opposed end 15, located within the protective cap 6, which may be used for loading the test strip 8 in the chamber 7, before to close the unit 2 with the protective cap 6.
  • said opened end 15 is closed by a protruding plug 16 located in a second housing 17 in the support 2.
  • a reaction tube 3 closed by a protruding plug 4 is placed in the housing 5 of the support 2.
  • the protective cap 6 is placed above the support 2.
  • the support 2 and the protective cap 6 are circular and rotatably engageable with each other.
  • the protective cap 6 is moved in a circular path with respect of the support 2.
  • the mating between the support 2 and the protective cap 6 is a locking mate that cannot be broken once made. This may ensure a secure containment of the contents of the unit during processing.
  • Guide means 10 are fixed within an inner volume of the protective cap 5. As illustrated figures 3A and 3B , the guide means 10 comprise or consist in a disk 11 comprising a first hole 12 for receiving and pulling out the protruding plug 4 of the reaction tube 3 and a second hole 13 for receiving and maintaining the test strip 8 substantially vertically with respect to the support 2. The diameter of the first hole 12 is greater than the diameter of the protruding plug 4.
  • first hole 12 In a first position ( Figures 1A ? 2A and 3A), the first hole 12 is in overlapping relationship with the reaction tube 3 and the protruding plug 4 of the reaction tube 3 is engaged through said first hole 12.
  • the second hole 13 is above a flate surface of the support ( figure 1A ) or above the second housing 17 of the support 2 ( figure 2A ) so that the protruding plug 16 located within the second housing 17 is engaged through said second hole 13.
  • the first hole 12 and the second hole 13 are diametrically opposed on the disk 11, so that a rotation of 180° must be performed to move the first and second holes 12, 13 to place the second hole 13 in overlapping relationship with the reaction tube 3 ( figures 1B and 2B ).
  • the holes 12, 13 may be arranged differently on the disk 11, e.g. separated of 90°, so that alternative rotations may be performed to position the second hole 13 in overlapping relationship with the reaction tube 3, e.g. a rotation of 90°.
  • the unit 1 may comprises several housings for reaction tubes and the guide means may comprise several sets of holes, in order to carry out several biological sample analysis simultaneously. The position of the sets of holes on the guide means may be adapted easily to the number of sets of holes and reaction tubes.
  • the rotation of the protective cap 6 simultaneously seals the protective cap 6 on the support 2, in order to isolate the inner volume of the support from external environment.
  • the rotation of the protective cap 6 results in a corresponding rotation of the guide means 10, which leads to the tearing of the protruding plug 4 of the reaction tube 3, and optionally of the protruding plug 16 of the chamber 7 ( figures 2A and 2B ).
  • the reaction tube 3 lays opened and the second hole 13 becomes aligned with the opened reaction tube 3, so that the test strip 8 falls by the action of gravity within the reaction tube 3.
  • the protruding plug 4 of the reaction tube 3, and optionally of the protruding plug 16 of the chamber 7 is/are displaced at the diametral opposite of the guide means 10.
  • retention means on the chamber 7 of the protective cap 6 and/or on the guide means 10, may help to maintain the test strip 8 substantially vertically with respect to the support 2 and the reaction tube 3.
  • the test strip 8 is advantageously maintained vertically during all the processing, to optimize the sample analysis and results visualization.
  • the unit may be a non-reusable, one-shot disposable unit.
  • the unit may comprise sealing means that irrevocably close the protective cap on the support and isolate the inner volume from the external environment.
  • the unit may be a reusable unit, which may be provided with several test strips to be used for successive analysis.
  • This enclosed unit 1 may be used for implementing a method for processing a biological sample while preventing cross-contamination.
  • this method comprises the steps:
  • test strip 8 may be placed in the chamber 7 before or after the closure of the support 2 with the protective cap 6.
  • FIG. 4A A second embodiment is illustrated by figures 4A, 4B and 5A, 5B .
  • an enclosed unit 20 for biological sample processing comprises a support 21 comprising a top part 22 and a base part 23.
  • the top part 22 comprises a chamber 24 for receiving a test strip 25 (i.e. reagent).
  • a test strip 25 i.e. reagent
  • the dimensions of the chamber 24 are similar to the dimensions of the test strip 25 so that the test strip is maintained substantially vertically in the chamber 24 with respect to the support 21 and a reaction tube 27.
  • the base part 23 comprises a housing 26 for receiving a reaction tube 27, closed by a protruding plug 28.
  • the support 23 has an access port for introduction of the reaction tube 27 within the housing 26 (not represented).
  • the reaction tube is translated to the housing in the support. This allows to introduce the reaction tube to the housing without the need for opening the unit.
  • the access port is protected by a seal, to ensure that the unit is free of contamination prior to introduction of the sample.
  • Guide means 29 extend transversally between the top part 22 and the base part 23 of the support 21, said guide means 29 being mounted slidably with respect to said top part 22 and base part 23 of the support 21.
  • the guide means 29 comprise or consist in a push-rod which comprises successively a first hole 30 for receiving and pulling out the protruding plug of a reaction tube and a second hole 31 for receiving the reagent ( Figures 5A and 5B ).
  • the first hole 30 is opened onto one extremity of the push-rod (i.e. it leads up to one extremity of the push-rod) to form a clamp able to receive and pull out the protruding plug of the reaction tube.
  • the first hole 30 extends from a first end 34 of the push rod 29, in a longitudinal direction with respect to a longitudinal axis A.
  • the second hole 31 extends in a transversal direction with respect to the longitudinal axis A ( figures 5A and 5B ).
  • the reaction tube 27, closed by the protruding plug 29 is first engaged in the housing 26.
  • the test strip 25 is loaded in the chamber 24 when the push rod 29 is engaged in a first position ( figure 4A ), wherein an upper part 32 of the push rod 29 closes the communication between an opening 33 of the chamber and the base part 23.
  • the opening 33 of the chamber is in overlapping relationship with the housing 26 and the reaction tube 27.
  • the test strip 25 is maintained in the chamber 24 by way of the upper part 32 of the push-rod 29.
  • the push-rod 29 is pushed in translation within the support 21.
  • This translation brings the first hole 30 in contact with the protruding plug 28 and a further translation allows to snatch the protruding plug 28 from the reaction tube 27.
  • the translation is performed until the second hole 31 is in overlapping relationship with the opening 33 of the chamber 24.
  • test strip 25 can fall by the action of gravity through the second hole 31 within the reaction tube 27 ( figure 4B ).
  • the dimensions of the second hole 31 are substantially similar to the dimensions of the opening 33 of the chamber 24.
  • the test strip 25 is maintained substantially vertically during all the processing, to optimize the sample analysis and result visualization.
  • the unit 20 may comprises several housings for reaction tubes and the guide means may comprise several sets of holes, in order to carry out several biological sample analysis simultaneously.
  • the position of the sets of holes on the guide means may be adapted easily to the number of sets of holes and reaction tubes.
  • This enclosed unit 20 may be used for implementing a method for processing a biological sample while preventing cross-contamination.
  • this method comprises the steps of:
EP20305989.4A 2020-09-07 2020-09-07 Geschlossene einheit zur verarbeitung biologischer proben und verwendungen davon Pending EP3964292A1 (de)

Priority Applications (1)

Application Number Priority Date Filing Date Title
EP20305989.4A EP3964292A1 (de) 2020-09-07 2020-09-07 Geschlossene einheit zur verarbeitung biologischer proben und verwendungen davon

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
EP20305989.4A EP3964292A1 (de) 2020-09-07 2020-09-07 Geschlossene einheit zur verarbeitung biologischer proben und verwendungen davon

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EP3964292A1 true EP3964292A1 (de) 2022-03-09

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Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
LU102921B1 (en) * 2022-03-25 2023-09-26 Stratec Se Consumable for sample processing in automated analyser

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4978502A (en) * 1987-01-05 1990-12-18 Dole Associates, Inc. Immunoassay or diagnostic device and method of manufacture
US20150346105A1 (en) * 2012-12-03 2015-12-03 The Secretary Of State For Environment, Food And Rural Affairs Device and apparatus
US20160033543A1 (en) * 2013-03-15 2016-02-04 Philip Stankus Apparatus and method for automated sample preparation and adaptor for use in the apparatus

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4978502A (en) * 1987-01-05 1990-12-18 Dole Associates, Inc. Immunoassay or diagnostic device and method of manufacture
US20150346105A1 (en) * 2012-12-03 2015-12-03 The Secretary Of State For Environment, Food And Rural Affairs Device and apparatus
US20160033543A1 (en) * 2013-03-15 2016-02-04 Philip Stankus Apparatus and method for automated sample preparation and adaptor for use in the apparatus

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
LU102921B1 (en) * 2022-03-25 2023-09-26 Stratec Se Consumable for sample processing in automated analyser
EP4249117A1 (de) 2022-03-25 2023-09-27 Stratec SE Verbrauchsmaterial zur probenverarbeitung in einem automatisierten analysegerät

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Designated state(s): AL AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LI LT LU LV MC MK MT NL NO PL PT RO RS SE SI SK SM TR