EP3854787A1 - Composé promédicament à base d'édaravone et son utilisation pharmaceutique dans le traitement ou le soulagement d'une maladie neurodégénérative ou d'une maladie des motoneurones - Google Patents
Composé promédicament à base d'édaravone et son utilisation pharmaceutique dans le traitement ou le soulagement d'une maladie neurodégénérative ou d'une maladie des motoneurones Download PDFInfo
- Publication number
- EP3854787A1 EP3854787A1 EP19861613.8A EP19861613A EP3854787A1 EP 3854787 A1 EP3854787 A1 EP 3854787A1 EP 19861613 A EP19861613 A EP 19861613A EP 3854787 A1 EP3854787 A1 EP 3854787A1
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- Prior art keywords
- carboxylate
- phenyl
- methyl
- pyrazol
- piperazine
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- 0 CC(C=C(C=*c1ccccc1)OC(*(CC1)CC*1C([C@@](*)CCNC)=O)=O)=* Chemical compound CC(C=C(C=*c1ccccc1)OC(*(CC1)CC*1C([C@@](*)CCNC)=O)=O)=* 0.000 description 2
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
- C07D231/02—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings
- C07D231/10—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
- C07D231/14—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D231/18—One oxygen or sulfur atom
- C07D231/20—One oxygen atom attached in position 3 or 5
- C07D231/22—One oxygen atom attached in position 3 or 5 with aryl radicals attached to ring nitrogen atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
- C07D231/02—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings
- C07D231/10—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
- C07D231/14—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D231/18—One oxygen or sulfur atom
- C07D231/20—One oxygen atom attached in position 3 or 5
Definitions
- the present invention relates to a novel prodrug of edaravone which is known to be useful in the treatment or improvement of neurodegenerative and motor neuron diseases such as Lou Gehrig's disease, or a pharmaceutically acceptable salt thereof.
- the present invention also relates to a pharmaceutical composition comprising such a novel prodrug or a pharmaceutically acceptable salt thereof as an active ingredient.
- the present invention also relates to a medical use using such a prodrug or a pharmaceutically acceptable salt thereof.
- edaravone is a drug that was newly approved as a treatment for Lou Gehrig's disease in the United States in 2017, and its effect has been proven, such as improving the revised ALS functional rating scale (ALSFRS-R) in clinical trials and dramatically reducing the level of 3-nitrotyrosine in cerebrospinal fluid (CSF).
- ALSFRS-R revised ALS functional rating scale
- CSF cerebrospinal fluid
- Alzheimer's disease shows the accumulation of amyloid- ⁇ and pathological characteristics resulting therefrom.
- Edaravone is reported to inhibit the deposition of amyloid-beta and thereby oxidative damage and inhibit disease progression.
- Parkinson's disease shows a lack of dopamine substances in the basal ganglia, which is the motor nerve center.
- edaravone was administered to a chronic rotenone rat model, a chronic Parkinson disease-induced animal, a muscle stiffness phenomenon (catalepsy), the regression of dopamine neurons and so on have been greatly improved. This was proven to be a result of the remarkable reduction of the oxygen species occurring in the midbrain by edaravone. ( PLoS One, 2011, 6 (6), e20677 )
- Edaravone is currently commercialized as an intravenous infusion (IV infusion), and is generally administered to patients at a repeat cycle of 60 mg each time on a 28-day basis.
- IV infusion intravenous infusion
- edaravone was administered for 10 days out of 14 days, and then it goes through a 14-day rest period.
- it is a very cumbersome process to visit the hospital for each administration and receive an injection for an hour.
- Pgp P-glycoprotein
- Chinese Patent Publication No. 102190622 proposes prodrugs having a specific structure, which is a piperazine derivative linked to the edaravone structure with a carbamate functional group. These compounds were administered orally or injected into an animal model to measure their antioxidant effect.
- the above publication does not disclose the pharmacokinetic aspects of the in vivo administration of the compounds, and the publication also does not disclose or hint the blood concentration of edaravone generated from the prodrug.
- the prodrugs disclosed in the Chinese patent were much insufficient to improve the bioavailability of edaravone, and therefore, the present inventors determined that a drug with more remarkably improved absorption and bioavailability was needed.
- the problem to be solved by the present invention is to provide a prodrug of edaravone with improved absorption rate, bioavailability, etc., a pharmaceutical composition comprising such a prodrug, and a medical use of such a prodrug for treating or improving neurodegenerative and/or motor neuron diseases.
- the present disclosure provides a compound represented by the following Chemical Formula 1 or a pharmaceutically acceptable salt thereof.
- Chemical Formula 1 a compound represented by the following Chemical Formula 1 or a pharmaceutically acceptable salt thereof.
- the present inventors confirmed a very excellent effect in terms of absorption rate and bioavailability of the compound or a pharmaceutically acceptable salt thereof, and in addition to such bioavailability aspects, the present inventors confirmed excellent physical properties or characteristics of the compound or a pharmaceutically acceptable salt thereof as a prodrug, thereby the present invention was completed.
- the compounds are 3-methyl-1-phenyl-1H-pyrazol-5-yl 4-acetylpiperazine-1-carboxylate; (S)-3-methyl-1-phenyl-1H-pyrazol-5-yl 4-acetyl-2-methylpiperazine-1-carboxylate; (R)-3-methyl-1-phenyl-1H-pyrazol-5-yl 4-acetyl-2-methylpiperazine-1-carboxylate; 3-methyl-1-phenyl-1H-pyrazol-5-yl 4-(cyclohexanecarbonyl)piperazine-1-carboxylate; 3-methyl-1-phenyl-1H-pyrazol-5-yl 4-benzoylpiperazine-1-carboxylate; 3-methyl-1-phenyl-1H-pyrazol-5-yl 4-(2-aminoacetyl)piperazine-1-carboxylate; (S)-3-methyl-1-phenyl-1H-pyrazol-5-yl 4-acetylpiperazine-1-car
- C x -C y means the number of carbon atoms is from x to y.
- (C 1 -C 3 )alkyl means an alkyl which carbon number is any integer of from 1 to 3.
- alkyl used in the present invention includes both linear and branched types.
- the term "pharmaceutically acceptable salt(s)” refers to a salt prepared from active compounds according to the present disclosure with relatively non-toxic acids or bases, depending on the particular substituents of those compounds.
- acid-added salts can be obtained by contacting the neutral compounds with a sufficient amount of the desired acid and pure or inert solvent.
- Suitable pharmaceutically acceptable acid addition salts include salts derived from non-toxic organic acids including, but are not limited to, acetic acid, propionic acid, isobutyl acid, oxalic acid, maleic acid, malonic acid, benzoic acid, succinic acid, suberic acid, fumaric acid, mandelic acid, phthalic acid, benzenesulfonic acid, p-tolylsulfonic acid, citric acid, tartaric acid, methanesulfonic acid, and the like, and non-toxic inorganic acids including, but are not limited to, hydrochloric acid, hydrobromic acid, nitric acid, carbonic acid, monohydrogencarbonic acid, phosphoric acid, monohydrogenphosphric acid, dihydrogenphosphoric acid, sulfuric acid, monohydrogensulfuric acid, hydrogen iodide, phosphorous acid and the like.
- non-toxic organic acids including, but are not limited to, acetic acid, propionic acid, is
- salts include a salt of amino acid such as arginate or its analogues, and it also includes analogues of organic acid such as glucuronic or galacturonic acid.
- analogues of organic acid such as glucuronic or galacturonic acid.
- salts are disclosed in well-known literature on the art, for example, Remington's Pharmaceutical Sciences, 18th eds., Mack Publishing, Easton PA (1990 ) or Remington : The Science and Practice of Pharmacy, 19th eds, are disclosed in Mack Publishing, Easton PA (1995 ).
- the phrase "compound(s) of this/the invention” includes any compound(s) of Chemical Formula 1, as well as clathrates, hydrates, solvates, or polymorphs thereof. And, even if the term “compound(s) of the invention” does not mention its pharmaceutically acceptable sat, the term includes salts thereof.
- the compounds of this disclosure include stereo-chemically pure compounds, e.g., those substantially free (e.g., greater than 85% ee, greater than 90% ee, greater than 95% ee, greater than 97% ee, or greater than 99% ee) of other stereoisomers.
- the compounds of Chemical Formula 1 according to the present disclosure or salts thereof are tautomeric isomers and/or stereoisomers (e.g., geometrical isomers and conformational isomers), such isolated isomers and their mixtures also are included in the scope of this disclosure. If the compounds of the present disclosure or salts thereof have an asymmetric carbon in their structures, their active optical isomers and their racemic mixtures also are included in the scope of this disclosure.
- polymorph refers to solid crystalline forms of a compound of this disclosure or complex thereof. Different polymorphs of the same compound can exhibit different physical, chemical and/or spectroscopic properties. Different physical properties include, but are not limited to stability (e.g., to heat or light), compressibility and density (important in formulation and product manufacturing), and dissolution rates (which can affect bioavailability).
- Differences in stability can result from changes in chemical reactivity (e.g., differential oxidation, such that a dosage form discolors more rapidly when comprised of one polymorph than when comprised of another polymorph) or mechanical characteristics (e.g., tablets crumble on storage as a kinetically favored polymorph converts to thermodynamically more stable polymorph) or both (e.g., tablets of one polymorph are more susceptible to breakdown at high humidity).
- chemical reactivity e.g., differential oxidation, such that a dosage form discolors more rapidly when comprised of one polymorph than when comprised of another polymorph
- mechanical characteristics e.g., tablets crumble on storage as a kinetically favored polymorph converts to thermodynamically more stable polymorph
- both e.g., tablets of one polymorph are more susceptible to breakdown at high humidity.
- Different physical properties of polymorphs can affect their processing. For example, one polymorph might be more likely to form solvates or might be more difficult to filter or wash free of impurities than another
- solvate means a compound or its salt according to this disclosure that further includes a stoichiometric or non-stoichiometric amount of a solvent bound by non-covalent intermolecular forces.
- Preferred solvents are volatile, non-toxic, and acceptable for administration to humans in trace amounts.
- hydrate means a compound or its salt according to this disclosure that further includes a stoichiometric or non-stoichiometric amount of water bound by non-covalent intermolecular forces.
- clathrate means a compound or its salt in the form of a crystal lattice that contains spaces (e.g., channels) that have a guest molecule (e.g., a solvent or water) trapped within.
- the compound represented by the Chemical Formula 1 of the present invention can be synthesized, for example, by the following route.
- the first substance used is a piperazine compound I substituted with R 1 and R 2 consisting of an alkyl group, and an amide intermediate II can be obtained as a result of reaction with an activated ester compound or a carboxylic acid compound containing an R 3 group.
- the carboxylic acid compound used at this time may include an amino acid in which the amine group is properly protected, and the protecting group is t-butoxycarbonyl (Boc) or fluorenylmethyloxycarbonyl (Fmoc) which is commonly used in amine groups.
- the group-protected carboxybenzyl (Cbz) group can be deprotected by hydrogenation to obtain intermediate III.
- Intermediate III can be activated by treatment with triphosgene and then reacted with edaravone IV to obtain final compound V. Meanwhile, when an amino acid having an amine group protected is used, a deprotection process may be separately performed in the final step.
- the present inventors have devised and manufactured a novel compound with a new structure capable of dramatically increasing the oral absorption rate upon oral administration by modifying the chemical structure of the edaravone compound.
- the blood concentration of the edaravone substance after in vivo oral administration of the novel compound is ultimately directly proportional to the efficacy of the drug for treating or improving various neurodegenerative and/or motor neuron diseases.
- intravenous and oral doses can be proportionally applied by comparing the concentration of edaravone exposed in blood through a metabolic process after oral administration of the prodrug according to the present invention based on the blood concentration of edaravone after intravenous administration.
- the present inventors prepared and evaluated compounds having various chemical structures in order to derive a novel compound with improved oral absorption.
- the absorption of the drug was evaluated by considering the degree of lipophilicity, taking into account that the absorption of the drug is basically performed by passive diffusion.
- the compounds according to the present invention can act as a substrate for amino acid transporters such as PepT1 and LAT1 among transmembrane transporters present in the intestinal membrane. Therefore, while edaravone has low bioavailability due to Pgp release, some of the compounds according to the present invention are considered to have a remarkably increased bioavailability due to active transport by an amino acid transporter.
- the present invention is not limited to this theoretical mechanism.
- the pharmacokinetic evaluation result of the compound of Example 10 below among the compounds of Chemical Formula 1 showed 88.2% of bioavailability when administered orally compared to edaravone administered intravenously. It was also confirmed that its oral bioavailability increased by about 18 times compared to the bioavailability (4.9%) of edaravone administered orally.
- the bioavailability of the compound of Example 15 administered orally was 60.7% compared to the edaravone administered intravenously, and it was a significant increase of 12 times compared to the bioavailability (4.9%) of edaravone administered orally.
- Example 2 compound of Chinese Patent CN 102190622 that is, 4-methyl-1-piperazinformyledaravone (same as the Reference Example 1 compound of this application; 3-methyl-1-phenyl-1H-pyrazol-5-yl 4-methylpiperazine-1-carboxylate) was evaluated and compared in the same manner as the example compounds newly presented in the present invention. As a result, the bioavailability of this compound was 12.0%. Therefore, the compounds of Chemical Formula 1 presented in the present invention, including the compounds of Examples 10 and 15 mentioned above, shows greatly improved oral bioavailability compared to the known substance of CN 102190622 .
- the present invention provides a pharmaceutical composition
- a pharmaceutical composition comprising a therapeutically effective amount of the compound of Chemical Formula 1 or a pharmaceutically acceptable salt thereof according to the present invention, and a pharmaceutically acceptable carrier.
- an "effective amount” means an amount of a compound of the present invention slowing or minimizing neurodegenerative and/or motor neuron disease; or sufficient to provide a therapeutic benefit in the treatment or management of neurodegenerative and/or motor neuron disease.
- a carrier for oral administration or a carrier for parenteral administration may be used.
- Carriers for oral administration may include lactose, starch, cellulose derivatives, magnesium stearate, stearic acid, and the like.
- carriers for parenteral administration may include water, suitable oil, saline, aqueous glucose and glycol, and the like, and may further include stabilizers and preservatives. Suitable stabilizers may be antioxidants such as sodium hydrogen sulfite, sodium sulfite or ascorbic acid. Suitable preservatives may be benzalkonium chloride, methyl- or propyl-paraben and chlorobutanol.
- Other pharmaceutically acceptable carriers may be referred to as those described in the following documents. ( Remington's Pharmaceutical Sciences, 19th ed., Mack Publishing Company, Easton, PA, 1995 )
- the pharmaceutical composition of the present invention can be administered to mammals including humans by any route of administration. It can be administered orally or parenterally. However, the oral route of administration is more preferable in terms of the fact that the compounds of the present invention show excellent oral absorption.
- Parenteral administration methods include, for example, but are not limited thereto, intravenous, intramuscular, intraarterial, intramedullary, intrathecal, intracardiac, transdermal, subcutaneous, intraperitoneal, intranasal, intestinal, topical, sublingual or rectal administration.
- the pharmaceutical composition of the present invention may be prepared in an injectable formulation and administered by a method of lightly pricking the skin with a 30 gauge thin injection needle, or directly applying it to the skin.
- the pharmaceutical composition of the present invention may be formulated as a formulation for oral administration or parenteral administration according to the route of administration as described above.
- the composition of the present invention may be formulated using a method known in the art such as powder, granule, tablet, pill, dragee, capsule, liquid, gel, syrup, slurry, suspension, etc.
- oral preparations can be obtained as a tablet by blending the active ingredient with a solid excipient, pulverizing it, adding a suitable adjuvant, and processing it into a granule mixture.
- excipients include sugars including as lactose, dextrose, sucrose, sorbitol, mannitol, xylitol, erythritol and maltitol; starches including corn starch, wheat starch, rice starch and potato starch; celluloses including cellulose, methyl cellulose, sodium carboxymethylcellulose and hydroxypropylmethylcellulose; gelatin; polyvinylpyrrolidone; and the like.
- cross-linked polyvinylpyrrolidone, agar, alginic acid or sodium alginate may be added as a disintegrant.
- the pharmaceutical composition of the present invention may further comprise an anti-aggregating agent, a lubricant, a wetting agent, a flavoring agent, an emulsifying agent and a preservative.
- a formulation for parenteral administration it can be formulated in the form of injections, creams, lotions, ointments for external use, oils, moisturizers, gels, aerosols, and nasal inhalants by a method known in the art. These formulations are described in Remington's Pharmaceutical Science, 15th Edition, 1975. Mack Publishing Company, Easton, Pennsylvania 18042, Chapter 87: Blaug, Seymour , which is well known for all pharmaceutical chemistry.
- the total dosage of the pharmaceutical composition of the present invention may be administered to a patient as a single dose, and may be administered by a fractionated treatment protocol that is administered for a long time in multiple doses.
- the pharmaceutical composition of the present invention may vary the content of the active ingredient according to the symptoms of the disease.
- the preferred total dose of the composition of the present invention may be about 0.01 ⁇ g to 1,000 mg, most preferably 0.1 ⁇ g to 100 mg per 1 kg of the patient's body weight per day.
- the appropriate effective dosage of the pharmaceutical composition of the present invention can be determined by conventional knowledge in the art based on the route of administration and the number of treatments as well as various factors such as the patient's age, weight, health condition, sex, disease severity, diet, and excretion rate.
- the pharmaceutical composition according to the present invention is not particularly limited to any specific formulation, route of administration, and method of administration as long as it exhibits the effects of the present invention.
- the pharmaceutical composition of the present invention may be administered as an individual therapeutic agent or administered in combination with other therapeutic agents.
- the composition of the present invention and the other therapeutic agents may be administered simultaneously, individually or sequentially.
- the other therapeutic agent may be a substance already known to have an effect of treating or improving neurodegenerative and/or motor neuron diseases.
- the pharmaceutical composition of the present invention is administered in combination with another therapeutic agent, the composition of the present invention and the other therapeutic agent may be separately formulated into separate containers, or may be formulated in combination in the same formulation.
- Compound A and Compound B presented below refer to substances presented as active ingredients for the treatment, improvement or prevention of neurodegenerative and motor neuron diseases in the present invention.
- Composition 1 Composition 1
- Composition 2 Active ingredient Compound A 30
- Compound B 60
- Lactose 20 30
- Compound B 60
- Lactose 20 30
- SLS Sodium lauryl sulfate
- PVP Polyvinyl pyrrolidone
- PVP Polyvinyl pyrrolidone
- Magnesium stearate 3 3 Total weight 65 120
- the present invention also provides a pharmaceutical composition for the treatment or improvement of neurodegenerative or motor neuron diseases, comprising the compound of Chemical Formula 1 or a pharmaceutically acceptable salt thereof according to the present invention as an active ingredient. That is, the present invention provides a medical use of the compound of Chemical Formula 1 or a pharmaceutically acceptable salt thereof according to the present invention for the treatment or improvement of neurodegenerative or motor neuron diseases.
- the present invention provides a method for treating or ameliorating a neurodegenerative or motor neuron disease comprising administering a therapeutically effective amount of a compound of Chemical Formula 1 or a pharmaceutically acceptable salt thereof to a subject in need thereof.
- the neurodegenerative or motor neuron disease is Alzheimer's disease, Parkinson's disease, Huntington's disease, Lou Gehrig's disease, multiple sclerosis, dystonia, spinal muscular atrophy, inflammatory neuropathy, or alcoholic dementia.
- the subject is a human.
- the treatment is preventative treatment.
- the treatment is palliative treatment.
- the treatment is restorative treatment.
- the present invention provides a compound effective in the treatment or amelioration of neurodegenerative or motor neuron diseases, a pharmaceutical composition comprising it as an active ingredient, their medical use, and a therapeutic method comprising administering it to a subject in need of treatment or prevention.
- the compound according to the present invention or a pharmaceutically acceptable salt thereof has various advantages as an active ingredient of a medical product in various aspects such as solubility, and particularly has excellent bioavailability after oral administration.
- reaction solution was cooled to 0 °C or less under an argon gas environment, and then 1.2 equivalents of triphosgene diluted in 15-fold volume of dichloromethane were slowly added dropwise and stirred. After stirring at room temperature for 2 hours, it was washed with saturated brine and the organic layer was separated. After drying over anhydrous magnesium sulfate, it was concentrated under reduced pressure to obtain a yellow oily substance. After 10-fold volume of acetonitrile was added thereto and completely dissolved, 1.0 equivalent of edaravone and 3.0 equivalent of cesium carbonate were added thereto. After stirring at room temperature to confirm the completion of the reaction, the reaction solution was filtered using Celite, and the filtrate was recovered and concentrated under reduced pressure.
- the pharmacokinetic test of the compounds of Examples and Reference Example was carried out as follows. That is, after a single oral administration of the test compound to SD (Sprague-Dawley) rats, the efficacy of the compound of the present invention was verified by tracking the kinetics of the edaravone released into the blood by metabolic processes and comparing it with a standard substance. Specifically, edaravone, a standard substance, was administered intravenously and orally, respectively, and the test compounds were administered orally. Then, the concentration of edaravone in blood was evaluated. The standard substance and the test compounds were each prepared in the same manner and then administered to rats at a dose of 0.1 mmol/kg, and blood was collected at a predetermined time and plasma was separated.
- the pretreatment method 100 ⁇ l of plasma sample was transferred to a tube for centrifugation, 10 ⁇ l of an internal standard solution and 300 ⁇ l of methanol were added, followed by mixing for about 30 seconds. The tube was centrifuged at 3,000 ⁇ g (4 °C) for about 5 minutes, the supernatant was taken and transferred to an LC vial, and then injected into the instrument.
- concentration of an active ingredient, that is, edaravone, in rat plasma was quantified by applying a previously validated analysis method.
- the average AUCt is 9,835 hr ⁇ ng/ml
- the average AUC i is 9,856 hr ⁇ ng/ml
- the average C max is 1,803 ng/ml
- the average T max is 1.00 hour
- the average t 1/2 is 2.51 hours
- the bioavailability was 88.2%.
- the average AUCt was 6,772 hr ⁇ ng/ml
- the average AUC i was 6,795 hr ⁇ ng/ml
- the average C max was 1,696 ng/ml
- the average T max was 0.42 hours
- the average t 1/2 was 2.69 hours
- the bioavailability was 60.7%.
- Example 10 As shown in the results of Table 3, in particular, the oral bioavailability of the compounds of Example 10, Example 19, Example 14, and Example 15 was excellent.
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Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
KR1020180111079A KR102261931B1 (ko) | 2018-09-17 | 2018-09-17 | 에다라본 전구체 약물 화합물 및 이들의 신경퇴행성 또는 운동신경 질환의 치료 또는 개선을 위한 의약 용도 |
PCT/KR2019/011639 WO2020060092A1 (fr) | 2018-09-17 | 2019-09-09 | Composé promédicament à base d'édaravone et son utilisation pharmaceutique dans le traitement ou le soulagement d'une maladie neurodégénérative ou d'une maladie des motoneurones |
Publications (2)
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EP3854787A1 true EP3854787A1 (fr) | 2021-07-28 |
EP3854787A4 EP3854787A4 (fr) | 2022-06-22 |
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EP19861613.8A Withdrawn EP3854787A4 (fr) | 2018-09-17 | 2019-09-09 | Composé promédicament à base d'édaravone et son utilisation pharmaceutique dans le traitement ou le soulagement d'une maladie neurodégénérative ou d'une maladie des motoneurones |
Country Status (6)
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US (1) | US11427547B2 (fr) |
EP (1) | EP3854787A4 (fr) |
JP (1) | JP2022501425A (fr) |
KR (1) | KR102261931B1 (fr) |
CN (1) | CN112714760A (fr) |
WO (1) | WO2020060092A1 (fr) |
Family Cites Families (5)
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CN1525856A (zh) | 2001-05-11 | 2004-09-01 | 三菱制药株式会社 | 含吡唑啉酮衍生物的稳定的高浓度注射剂 |
CN102190622B (zh) | 2010-03-15 | 2015-01-07 | 李勤耕 | 依达拉奉的水溶性衍生物及其制备方法和应用 |
JP6100883B2 (ja) * | 2012-03-19 | 2017-03-22 | アビデ セラピューティクス,インク. | カルバマート化合物、及びその製造並びに使用 |
CN104098512A (zh) * | 2013-04-03 | 2014-10-15 | 江苏先声药物研究有限公司 | 依达拉奉衍生物及其制备方法、检测方法和用途 |
CN108314652A (zh) | 2017-01-18 | 2018-07-24 | 周意 | 依达拉奉衍生物及其用途 |
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2018
- 2018-09-17 KR KR1020180111079A patent/KR102261931B1/ko active IP Right Grant
-
2019
- 2019-09-09 US US17/276,351 patent/US11427547B2/en active Active
- 2019-09-09 CN CN201980060850.1A patent/CN112714760A/zh active Pending
- 2019-09-09 WO PCT/KR2019/011639 patent/WO2020060092A1/fr unknown
- 2019-09-09 JP JP2021539321A patent/JP2022501425A/ja active Pending
- 2019-09-09 EP EP19861613.8A patent/EP3854787A4/fr not_active Withdrawn
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WO2020060092A1 (fr) | 2020-03-26 |
CN112714760A (zh) | 2021-04-27 |
JP2022501425A (ja) | 2022-01-06 |
US11427547B2 (en) | 2022-08-30 |
KR20200031938A (ko) | 2020-03-25 |
US20220033359A1 (en) | 2022-02-03 |
EP3854787A4 (fr) | 2022-06-22 |
KR102261931B1 (ko) | 2021-06-07 |
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