EP3775163A4 - METHOD OF INDUCING OR ENHANCEMENT OF THE WOUND HEALING PROPERTIES OF MESENCHYMAL STEM CELLS - Google Patents

METHOD OF INDUCING OR ENHANCEMENT OF THE WOUND HEALING PROPERTIES OF MESENCHYMAL STEM CELLS Download PDF

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Publication number
EP3775163A4
EP3775163A4 EP19784508.4A EP19784508A EP3775163A4 EP 3775163 A4 EP3775163 A4 EP 3775163A4 EP 19784508 A EP19784508 A EP 19784508A EP 3775163 A4 EP3775163 A4 EP 3775163A4
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EP
European Patent Office
Prior art keywords
mesenchymate
inducing
enhancing
stem cells
healing properties
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
EP19784508.4A
Other languages
German (de)
English (en)
French (fr)
Other versions
EP3775163A1 (en
Inventor
Toan Thang Phan
Gavin TAN
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
CellResearch Corp Pte Ltd
Original Assignee
CellResearch Corp Pte Ltd
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Filing date
Publication date
Application filed by CellResearch Corp Pte Ltd filed Critical CellResearch Corp Pte Ltd
Publication of EP3775163A1 publication Critical patent/EP3775163A1/en
Publication of EP3775163A4 publication Critical patent/EP3775163A4/en
Pending legal-status Critical Current

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    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/06—Animal cells or tissues; Human cells or tissues
    • C12N5/0602—Vertebrate cells
    • C12N5/0652—Cells of skeletal and connective tissues; Mesenchyme
    • C12N5/0662—Stem cells
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
    • A61K35/28—Bone marrow; Haematopoietic stem cells; Mesenchymal stem cells of any origin, e.g. adipose-derived stem cells
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/02—Drugs for dermatological disorders for treating wounds, ulcers, burns, scars, keloids, or the like
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/0068—General culture methods using substrates
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/06—Animal cells or tissues; Human cells or tissues
    • C12N5/0602—Vertebrate cells
    • C12N5/0652—Cells of skeletal and connective tissues; Mesenchyme
    • C12N5/0662—Stem cells
    • C12N5/0663—Bone marrow mesenchymal stem cells (BM-MSC)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/06—Animal cells or tissues; Human cells or tissues
    • C12N5/0602—Vertebrate cells
    • C12N5/0652—Cells of skeletal and connective tissues; Mesenchyme
    • C12N5/0662—Stem cells
    • C12N5/0665—Blood-borne mesenchymal stem cells, e.g. from umbilical cord blood
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/06—Animal cells or tissues; Human cells or tissues
    • C12N5/0602—Vertebrate cells
    • C12N5/0652—Cells of skeletal and connective tissues; Mesenchyme
    • C12N5/0662—Stem cells
    • C12N5/0667—Adipose-derived stem cells [ADSC]; Adipose stromal stem cells
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/06—Animal cells or tissues; Human cells or tissues
    • C12N5/0602—Vertebrate cells
    • C12N5/0652—Cells of skeletal and connective tissues; Mesenchyme
    • C12N5/0662—Stem cells
    • C12N5/0668—Mesenchymal stem cells from other natural sources
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2501/00—Active agents used in cell culture processes, e.g. differentation
    • C12N2501/10—Growth factors
    • C12N2501/11—Epidermal growth factor [EGF]
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2501/00—Active agents used in cell culture processes, e.g. differentation
    • C12N2501/30—Hormones
    • C12N2501/33—Insulin
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2501/00—Active agents used in cell culture processes, e.g. differentation
    • C12N2501/30—Hormones
    • C12N2501/38—Hormones with nuclear receptors
    • C12N2501/395—Thyroid hormones
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2509/00—Methods for the dissociation of cells, e.g. specific use of enzymes
    • C12N2509/10—Mechanical dissociation

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Chemical & Material Sciences (AREA)
  • Zoology (AREA)
  • Organic Chemistry (AREA)
  • Biotechnology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Developmental Biology & Embryology (AREA)
  • Genetics & Genomics (AREA)
  • Wood Science & Technology (AREA)
  • General Health & Medical Sciences (AREA)
  • Cell Biology (AREA)
  • Biochemistry (AREA)
  • General Engineering & Computer Science (AREA)
  • Microbiology (AREA)
  • Rheumatology (AREA)
  • Hematology (AREA)
  • Immunology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Epidemiology (AREA)
  • Virology (AREA)
  • Dermatology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Peptides Or Proteins (AREA)
EP19784508.4A 2018-04-12 2019-04-12 METHOD OF INDUCING OR ENHANCEMENT OF THE WOUND HEALING PROPERTIES OF MESENCHYMAL STEM CELLS Pending EP3775163A4 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201862656531P 2018-04-12 2018-04-12
PCT/SG2019/050204 WO2019199234A1 (en) 2018-04-12 2019-04-12 A method of inducing or improving wound healing properties of mesenchymal stem cells

Publications (2)

Publication Number Publication Date
EP3775163A1 EP3775163A1 (en) 2021-02-17
EP3775163A4 true EP3775163A4 (en) 2022-03-09

Family

ID=68163253

Family Applications (1)

Application Number Title Priority Date Filing Date
EP19784508.4A Pending EP3775163A4 (en) 2018-04-12 2019-04-12 METHOD OF INDUCING OR ENHANCEMENT OF THE WOUND HEALING PROPERTIES OF MESENCHYMAL STEM CELLS

Country Status (12)

Country Link
EP (1) EP3775163A4 (https=)
JP (2) JP7541730B2 (https=)
KR (1) KR20200143399A (https=)
CN (2) CN120608017A (https=)
AU (1) AU2019250653B2 (https=)
BR (1) BR112020020092A2 (https=)
CA (1) CA3095490A1 (https=)
PH (1) PH12020551658A1 (https=)
SG (1) SG11202009687PA (https=)
TW (1) TWI882956B (https=)
WO (1) WO2019199234A1 (https=)
ZA (1) ZA202005967B (https=)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU2020362379A1 (en) 2019-10-08 2022-04-07 Cellresearch Corporation Pte. Ltd. A method of assessing wound healing potency of a mesenchymal stem population and related methods of selecting mesenchymal stem cells and identifying tissue as starting material for producing a mesenchymal stem cell population
WO2021071430A1 (en) * 2019-10-08 2021-04-15 Cellresearch Corporation Pte. Ltd. A mesenchymal stem cell storing or transport formulation and methods of making and using the same
WO2021257073A1 (en) * 2020-06-17 2021-12-23 Joy Kong Method for producing mesenchymal stem cells from neonatal stem cells
WO2022004938A1 (ko) * 2020-06-30 2022-01-06 주식회사 미래셀바이오 유사 중간엽 줄기세포의 제조방법
CN114196626A (zh) * 2022-02-16 2022-03-18 北京国卫生物科技有限公司 脐带间充质干细胞及其分离培养扩增方法
WO2024107102A1 (en) * 2022-11-17 2024-05-23 Cellresearch Corporation Pte. Ltd. Use of conditioned medium derived from cultivation of mesenchymal stem cells of the umbilical cord for inducing, stimulating and promoting hair growth and regeneration
WO2024123237A1 (en) * 2022-12-09 2024-06-13 Cellresearch Corporation Pte. Ltd. Use of conditioned medium of cord lining mesenchymal stem cells for healing and/or preventing the formation and/or recurrence of a wound or a damaged skin area

Citations (4)

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Publication number Priority date Publication date Assignee Title
CN103301154A (zh) * 2013-04-19 2013-09-18 胡祥 脐带间充质干细胞在制备治疗红斑狼疮的制剂中的用途
CN106119191A (zh) * 2016-07-05 2016-11-16 四川华皓生物科技有限公司 一种胎盘绒毛板间充质干细胞及临床化制备方法
CN106377544A (zh) * 2016-09-30 2017-02-08 广州赛莱拉干细胞科技股份有限公司 脐带间充质干细胞上清液在制备治疗口腔溃疡药物中的应用及漱口液和其制备方法
WO2019199230A1 (en) * 2018-04-09 2019-10-17 Cellresearch Corporation Pte. Ltd. A method of transporting mesenchymal stem cells by means of a cell culture medium and a method of administering stem cells to wounds

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EP1288293A1 (en) 2001-08-30 2003-03-05 Norio Sakuragawa Human neural stem cells originated from human amniotic mesenchymal cell layer
WO2004072273A1 (en) 2003-02-11 2004-08-26 Davies John E Progenitor cells from wharton's jelly of human umbilical cord
TWI287010B (en) * 2003-06-12 2007-09-21 Euro Celtique Sa Therapeutic agents useful for treating pain
PL1789534T3 (pl) 2004-08-16 2015-03-31 Cellresearch Corp Pte Ltd Wyodrębnienie komórek macierzystych/progenitorowych z błony owodniowej pępowiny
CN101189341B (zh) * 2005-04-04 2016-10-19 纳幕尔杜邦公司 用于制备抗真菌病原体的植物的多核苷酸和方法
CN103555655B (zh) * 2005-10-21 2018-02-27 细胞研究私人有限公司 自脐带羊膜分离和培养干/祖细胞及其分化的细胞的应用
WO2007121263A2 (en) * 2006-04-14 2007-10-25 Wako Pure Chemical Industries, Ltd Structure for introducing a plurality of solutions, micro fluidic device having said structure and method for introducing solution
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KR101138091B1 (ko) * 2011-08-31 2012-04-24 세원셀론텍(주) 중간엽 줄기세포 기본 배양 배지 조성방법, 중간엽 줄기세포 기본 배양 배지 및 이를 이용하여 배양분화된 세포치료제
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PL3523421T3 (pl) 2016-10-05 2025-06-09 Cellresearch Corporation Pte. Ltd. Sposób izolowania mezenchymalnych komórek macierzystych z błony owodniowej pępowiny przy użyciu podłoża do hodowli komórkowej

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN103301154A (zh) * 2013-04-19 2013-09-18 胡祥 脐带间充质干细胞在制备治疗红斑狼疮的制剂中的用途
CN106119191A (zh) * 2016-07-05 2016-11-16 四川华皓生物科技有限公司 一种胎盘绒毛板间充质干细胞及临床化制备方法
CN106377544A (zh) * 2016-09-30 2017-02-08 广州赛莱拉干细胞科技股份有限公司 脐带间充质干细胞上清液在制备治疗口腔溃疡药物中的应用及漱口液和其制备方法
WO2019199230A1 (en) * 2018-04-09 2019-10-17 Cellresearch Corporation Pte. Ltd. A method of transporting mesenchymal stem cells by means of a cell culture medium and a method of administering stem cells to wounds

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Title
See also references of WO2019199234A1 *

Also Published As

Publication number Publication date
JP2024069365A (ja) 2024-05-21
JP2021526125A (ja) 2021-09-30
SG11202009687PA (en) 2020-10-29
CN120608017A (zh) 2025-09-09
ZA202005967B (en) 2021-08-25
JP7541730B2 (ja) 2024-08-29
AU2019250653A1 (en) 2020-10-15
PH12020551658A1 (en) 2021-07-26
EP3775163A1 (en) 2021-02-17
KR20200143399A (ko) 2020-12-23
TW202012618A (zh) 2020-04-01
TWI882956B (zh) 2025-05-11
CN112262211B (zh) 2025-05-09
BR112020020092A2 (pt) 2021-02-17
CN112262211A (zh) 2021-01-22
AU2019250653B2 (en) 2025-06-19
CA3095490A1 (en) 2019-10-17
WO2019199234A1 (en) 2019-10-17

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