TWI882956B - 一種誘導或改善間質幹細胞傷口癒合特性的方法 - Google Patents

一種誘導或改善間質幹細胞傷口癒合特性的方法 Download PDF

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TWI882956B
TWI882956B TW108112754A TW108112754A TWI882956B TW I882956 B TWI882956 B TW I882956B TW 108112754 A TW108112754 A TW 108112754A TW 108112754 A TW108112754 A TW 108112754A TW I882956 B TWI882956 B TW I882956B
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mesenchymal stem
stem cell
cell population
umbilical cord
medium
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TW108112754A
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TW202012618A (zh
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東森 樊
蓋文 陳
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新加坡商細胞研究私人有限公司
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    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/06—Animal cells or tissues; Human cells or tissues
    • C12N5/0602—Vertebrate cells
    • C12N5/0652—Cells of skeletal and connective tissues; Mesenchyme
    • C12N5/0662—Stem cells
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
    • A61K35/28—Bone marrow; Haematopoietic stem cells; Mesenchymal stem cells of any origin, e.g. adipose-derived stem cells
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/02—Drugs for dermatological disorders for treating wounds, ulcers, burns, scars, keloids, or the like
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    • C12N5/0602—Vertebrate cells
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    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/06—Animal cells or tissues; Human cells or tissues
    • C12N5/0602—Vertebrate cells
    • C12N5/0652—Cells of skeletal and connective tissues; Mesenchyme
    • C12N5/0662—Stem cells
    • C12N5/0665—Blood-borne mesenchymal stem cells, e.g. from umbilical cord blood
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    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/06—Animal cells or tissues; Human cells or tissues
    • C12N5/0602—Vertebrate cells
    • C12N5/0652—Cells of skeletal and connective tissues; Mesenchyme
    • C12N5/0662—Stem cells
    • C12N5/0667—Adipose-derived stem cells [ADSC]; Adipose stromal stem cells
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    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/06—Animal cells or tissues; Human cells or tissues
    • C12N5/0602—Vertebrate cells
    • C12N5/0652—Cells of skeletal and connective tissues; Mesenchyme
    • C12N5/0662—Stem cells
    • C12N5/0668—Mesenchymal stem cells from other natural sources
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    • C12N2501/00—Active agents used in cell culture processes, e.g. differentation
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    • C12N2501/00—Active agents used in cell culture processes, e.g. differentation
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    • C12N2501/395—Thyroid hormones
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    • C12N2509/00—Methods for the dissociation of cells, e.g. specific use of enzymes
    • C12N2509/10—Mechanical dissociation

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  • Wood Science & Technology (AREA)
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  • Animal Behavior & Ethology (AREA)
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  • Dermatology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Peptides Or Proteins (AREA)
TW108112754A 2018-04-12 2019-04-11 一種誘導或改善間質幹細胞傷口癒合特性的方法 TWI882956B (zh)

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US201862656531P 2018-04-12 2018-04-12
US62/656,531 2018-04-12

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TW202012618A TW202012618A (zh) 2020-04-01
TWI882956B true TWI882956B (zh) 2025-05-11

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EP (1) EP3775163A4 (https=)
JP (2) JP7541730B2 (https=)
KR (1) KR20200143399A (https=)
CN (2) CN120608017A (https=)
AU (1) AU2019250653B2 (https=)
BR (1) BR112020020092A2 (https=)
CA (1) CA3095490A1 (https=)
PH (1) PH12020551658A1 (https=)
SG (1) SG11202009687PA (https=)
TW (1) TWI882956B (https=)
WO (1) WO2019199234A1 (https=)
ZA (1) ZA202005967B (https=)

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AU2020362379A1 (en) 2019-10-08 2022-04-07 Cellresearch Corporation Pte. Ltd. A method of assessing wound healing potency of a mesenchymal stem population and related methods of selecting mesenchymal stem cells and identifying tissue as starting material for producing a mesenchymal stem cell population
WO2021071430A1 (en) * 2019-10-08 2021-04-15 Cellresearch Corporation Pte. Ltd. A mesenchymal stem cell storing or transport formulation and methods of making and using the same
WO2021257073A1 (en) * 2020-06-17 2021-12-23 Joy Kong Method for producing mesenchymal stem cells from neonatal stem cells
WO2022004938A1 (ko) * 2020-06-30 2022-01-06 주식회사 미래셀바이오 유사 중간엽 줄기세포의 제조방법
CN114196626A (zh) * 2022-02-16 2022-03-18 北京国卫生物科技有限公司 脐带间充质干细胞及其分离培养扩增方法
WO2024107102A1 (en) * 2022-11-17 2024-05-23 Cellresearch Corporation Pte. Ltd. Use of conditioned medium derived from cultivation of mesenchymal stem cells of the umbilical cord for inducing, stimulating and promoting hair growth and regeneration
WO2024123237A1 (en) * 2022-12-09 2024-06-13 Cellresearch Corporation Pte. Ltd. Use of conditioned medium of cord lining mesenchymal stem cells for healing and/or preventing the formation and/or recurrence of a wound or a damaged skin area

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JP2024069365A (ja) 2024-05-21
JP2021526125A (ja) 2021-09-30
SG11202009687PA (en) 2020-10-29
CN120608017A (zh) 2025-09-09
ZA202005967B (en) 2021-08-25
JP7541730B2 (ja) 2024-08-29
EP3775163A4 (en) 2022-03-09
AU2019250653A1 (en) 2020-10-15
PH12020551658A1 (en) 2021-07-26
EP3775163A1 (en) 2021-02-17
KR20200143399A (ko) 2020-12-23
TW202012618A (zh) 2020-04-01
CN112262211B (zh) 2025-05-09
BR112020020092A2 (pt) 2021-02-17
CN112262211A (zh) 2021-01-22
AU2019250653B2 (en) 2025-06-19
CA3095490A1 (en) 2019-10-17
WO2019199234A1 (en) 2019-10-17

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