EP3684348A4 - Traitement de maladie avec des esters d'agonistes de rxr sélectifs - Google Patents
Traitement de maladie avec des esters d'agonistes de rxr sélectifs Download PDFInfo
- Publication number
- EP3684348A4 EP3684348A4 EP18859557.3A EP18859557A EP3684348A4 EP 3684348 A4 EP3684348 A4 EP 3684348A4 EP 18859557 A EP18859557 A EP 18859557A EP 3684348 A4 EP3684348 A4 EP 3684348A4
- Authority
- EP
- European Patent Office
- Prior art keywords
- esters
- disease
- treatment
- rxr agonists
- selective rxr
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 239000000556 agonist Substances 0.000 title 1
- 201000010099 disease Diseases 0.000 title 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 title 1
- 150000002148 esters Chemical class 0.000 title 1
Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/21—Esters, e.g. nitroglycerine, selenocyanates
- A61K31/215—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids
- A61K31/216—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids of acids having aromatic rings, e.g. benactizyne, clofibrate
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
- A61K31/19—Carboxylic acids, e.g. valproic acid
- A61K31/195—Carboxylic acids, e.g. valproic acid having an amino group
- A61K31/197—Carboxylic acids, e.g. valproic acid having an amino group the amino and the carboxyl groups being attached to the same acyclic carbon chain, e.g. gamma-aminobutyric acid [GABA], beta-alanine, epsilon-aminocaproic acid or pantothenic acid
- A61K31/198—Alpha-amino acids, e.g. alanine or edetic acid [EDTA]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P21/00—Drugs for disorders of the muscular or neuromuscular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
- A61P25/16—Anti-Parkinson drugs
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0043—Nose
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0053—Mouth and digestive tract, i.e. intraoral and peroral administration
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
- Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
- Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Neurology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Organic Chemistry (AREA)
- Biomedical Technology (AREA)
- Neurosurgery (AREA)
- Epidemiology (AREA)
- Immunology (AREA)
- Emergency Medicine (AREA)
- Psychology (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Physical Education & Sports Medicine (AREA)
- Hospice & Palliative Care (AREA)
- Psychiatry (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US201762560776P | 2017-09-20 | 2017-09-20 | |
PCT/US2018/052031 WO2019060600A1 (fr) | 2017-09-20 | 2018-09-20 | Traitement de maladie avec des esters d'agonistes de rxr sélectifs |
Publications (2)
Publication Number | Publication Date |
---|---|
EP3684348A1 EP3684348A1 (fr) | 2020-07-29 |
EP3684348A4 true EP3684348A4 (fr) | 2021-08-18 |
Family
ID=65719743
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
EP18859557.3A Pending EP3684348A4 (fr) | 2017-09-20 | 2018-09-20 | Traitement de maladie avec des esters d'agonistes de rxr sélectifs |
Country Status (6)
Country | Link |
---|---|
US (3) | US11517549B2 (fr) |
EP (1) | EP3684348A4 (fr) |
AU (1) | AU2018335393A1 (fr) |
CA (1) | CA3076373A1 (fr) |
MX (1) | MX2020003223A (fr) |
WO (1) | WO2019060600A1 (fr) |
Families Citing this family (8)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
ES2690304T3 (es) | 2005-09-30 | 2018-11-20 | Io Therapeutics, Llc | Tratamiento del cáncer con agonistas específicos de RXR |
CN104114171A (zh) | 2011-12-13 | 2014-10-22 | Io治疗公司 | 使用rxr激动剂的自身免疫紊乱的治疗 |
CN108289958A (zh) | 2015-10-31 | 2018-07-17 | Io治疗公司 | 使用rxr激动剂和甲状腺激素的组合治疗神经系统紊乱 |
CN115227825A (zh) | 2016-03-10 | 2022-10-25 | Io治疗公司 | Rxr激动剂和甲状腺激素在制备用于治疗自身免疫疾病的药物中的用途 |
WO2017155578A1 (fr) | 2016-03-10 | 2017-09-14 | Io Therapeutics, Inc. | Traitement de troubles musculaires avec des combinaisons d'agonistes de rxr et d'hormones thyroïdiennes |
US11517549B2 (en) | 2017-09-20 | 2022-12-06 | Io Therapeutics, Inc. | Treatment of disease with esters of selective RXR agonists |
US10966950B2 (en) | 2019-06-11 | 2021-04-06 | Io Therapeutics, Inc. | Use of an RXR agonist in treating HER2+ cancers |
WO2023108012A1 (fr) | 2021-12-07 | 2023-06-15 | Io Therapeutics, Inc. | Utilisation d'un agoniste de rxr et de taxanes dans le traitement de cancers her2+ |
Citations (4)
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WO2017075610A1 (fr) * | 2015-10-31 | 2017-05-04 | Io Therapeutics, Inc. | Traitement de troubles du système nerveux à l'aide de doses d'hormones thyroïdiennes d'agonistes de rxr |
WO2017155578A1 (fr) * | 2016-03-10 | 2017-09-14 | Io Therapeutics, Inc. | Traitement de troubles musculaires avec des combinaisons d'agonistes de rxr et d'hormones thyroïdiennes |
WO2017155577A1 (fr) * | 2016-03-10 | 2017-09-14 | Io Therapeutics, Inc. | Traitement de maladies auto-immunes à l'aide de combinaisons d'agonistes de rxr et d'hormones thyroïdiennes |
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- 2018-09-20 AU AU2018335393A patent/AU2018335393A1/en active Pending
- 2018-09-20 EP EP18859557.3A patent/EP3684348A4/fr active Pending
- 2018-09-20 CA CA3076373A patent/CA3076373A1/fr active Pending
- 2018-09-20 MX MX2020003223A patent/MX2020003223A/es unknown
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2022
- 2022-11-02 US US17/979,670 patent/US20230126763A1/en active Pending
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Also Published As
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US11517549B2 (en) | 2022-12-06 |
US20230129034A1 (en) | 2023-04-27 |
CA3076373A1 (fr) | 2019-03-28 |
MX2020003223A (es) | 2020-09-21 |
US20230126763A1 (en) | 2023-04-27 |
EP3684348A1 (fr) | 2020-07-29 |
US20190083441A1 (en) | 2019-03-21 |
AU2018335393A1 (en) | 2020-04-02 |
WO2019060600A1 (fr) | 2019-03-28 |
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