EP3669981B1 - Druckdichtes vorratsgefäss enthaltend eine flüssigkeit - Google Patents
Druckdichtes vorratsgefäss enthaltend eine flüssigkeit Download PDFInfo
- Publication number
- EP3669981B1 EP3669981B1 EP18215204.1A EP18215204A EP3669981B1 EP 3669981 B1 EP3669981 B1 EP 3669981B1 EP 18215204 A EP18215204 A EP 18215204A EP 3669981 B1 EP3669981 B1 EP 3669981B1
- Authority
- EP
- European Patent Office
- Prior art keywords
- storage vessel
- liquid
- magazine
- main body
- storage
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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Images
Classifications
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- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
- B01L3/52—Containers specially adapted for storing or dispensing a reagent
- B01L3/523—Containers specially adapted for storing or dispensing a reagent with means for closing or opening
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- B—PERFORMING OPERATIONS; TRANSPORTING
- B65—CONVEYING; PACKING; STORING; HANDLING THIN OR FILAMENTARY MATERIAL
- B65D—CONTAINERS FOR STORAGE OR TRANSPORT OF ARTICLES OR MATERIALS, e.g. BAGS, BARRELS, BOTTLES, BOXES, CANS, CARTONS, CRATES, DRUMS, JARS, TANKS, HOPPERS, FORWARDING CONTAINERS; ACCESSORIES, CLOSURES, OR FITTINGS THEREFOR; PACKAGING ELEMENTS; PACKAGES
- B65D79/00—Kinds or details of packages, not otherwise provided for
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- B—PERFORMING OPERATIONS; TRANSPORTING
- B65—CONVEYING; PACKING; STORING; HANDLING THIN OR FILAMENTARY MATERIAL
- B65B—MACHINES, APPARATUS OR DEVICES FOR, OR METHODS OF, PACKAGING ARTICLES OR MATERIALS; UNPACKING
- B65B1/00—Packaging fluent solid material, e.g. powders, granular or loose fibrous material, loose masses of small articles, in individual containers or receptacles, e.g. bags, sacks, boxes, cartons, cans, or jars
- B65B1/04—Methods of, or means for, filling the material into the containers or receptacles
- B65B1/16—Methods of, or means for, filling the material into the containers or receptacles by pneumatic means, e.g. by suction
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- B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
- B01L3/50—Containers for the purpose of retaining a material to be analysed, e.g. test tubes
- B01L3/508—Containers for the purpose of retaining a material to be analysed, e.g. test tubes rigid containers not provided for above
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- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
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- B01L9/06—Test-tube stands; Test-tube holders
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- B—PERFORMING OPERATIONS; TRANSPORTING
- B65—CONVEYING; PACKING; STORING; HANDLING THIN OR FILAMENTARY MATERIAL
- B65D—CONTAINERS FOR STORAGE OR TRANSPORT OF ARTICLES OR MATERIALS, e.g. BAGS, BARRELS, BOTTLES, BOXES, CANS, CARTONS, CRATES, DRUMS, JARS, TANKS, HOPPERS, FORWARDING CONTAINERS; ACCESSORIES, CLOSURES, OR FITTINGS THEREFOR; PACKAGING ELEMENTS; PACKAGES
- B65D81/00—Containers, packaging elements, or packages, for contents presenting particular transport or storage problems, or adapted to be used for non-packaging purposes after removal of contents
- B65D81/18—Containers, packaging elements, or packages, for contents presenting particular transport or storage problems, or adapted to be used for non-packaging purposes after removal of contents providing specific environment for contents, e.g. temperature above or below ambient
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- B01L2300/041—Connecting closures to device or container
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- B01L2400/04—Moving fluids with specific forces or mechanical means
- B01L2400/0475—Moving fluids with specific forces or mechanical means specific mechanical means and fluid pressure
- B01L2400/0487—Moving fluids with specific forces or mechanical means specific mechanical means and fluid pressure fluid pressure, pneumatics
Definitions
- the present invention relates to a pressure-tight storage vessel containing a liquid and also having an elongate base body which is rotationally symmetrical to an axis of symmetry and which forms a rotationally symmetrical cavity at least in sections or at least in part, in which the liquid is essentially or for the most part accommodated.
- the base body is closed off on its underside by a base and also has an opening on its top side, which is closed in a pressure-tight manner by a closure, further having a plurality of reinforcement elements lying on the outside of the base body and extending parallel to the axis of symmetry of the base body, in particular in the longitudinal direction of the base body, and which are arranged rotationally symmetrically about the axis of symmetry of the base body, so that between adjacent reinforcement elements respective Wan exposed from the outside d sections of the base body are formed, and wherein the nature of the exposed wall sections allows a pressure-closing puncture by at least two hollow needles, the nature of the exposed wall sections allows a pressure-closing puncture by at least two hollow needles, the base body on the exposed wall sections for pricking the needles no separating seam and has no sprue residues, the closure of the storage vessel being a film which is attached to the border by means of a melting process, the base body having a recess on the underside of the
- the invention also relates to a method for transferring a liquid from a storage vessel into a reaction vessel, comprising the steps of providing a storage vessel according to the invention, puncturing a first hollow needle, which is connected to a rinsing liquid reservoir, and puncturing a second hollow needle, which is connected to the reaction vessel is, as well as introducing rinsing liquid via the first hollow needle from the rinsing liquid reservoir into the storage vessel while expelling the liquid via the second hollow needle from the storage vessel into the reaction vessel.
- the invention relates to a magazine for storing several storage vessels with at least one storage vessel according to the invention.
- inhomogeneous liquids for example suspensions of beads in an aqueous solution, the density of which is higher than that of water, so that the beads can sink to the bottom. If such an aqueous solution is mixed to homogeneity and then portioned, the proportion of beads in the aqueous phase decreases during portioning until all the beads have sedimented. The number of beads per portion falls accordingly, and portions filled at the beginning of portioning have a higher quantity of beads than those filled later.
- beads of this type easily accumulate on surfaces in the liquid phase, for example underneath the lid of the storage vessel. This also makes it more difficult to remove portions with the same concentration of beads, particularly in the case of automated processes in which the position of the beads within the transport vessel and their complete transfer are not checked visually.
- Beads are used as carriers for reagents in many miniaturized systems.
- the beads in the field of immunodiagnostics, they can be carriers for immobilized antigens to which antibodies to be detected in human samples bind. If such beads are incubated with a liquid sample, the antigen-antibody complex, which is immobilized on the bead, is formed if the antibodies are present. After a washing step, this complex can be purified with suitable reagents, e.g. B. a labeled secondary antibody can be detected.
- suitable reagents e.g. B. a labeled secondary antibody can be detected.
- suitable reagents e.g. B.
- a labeled secondary antibody can be detected.
- the commercially available random access analyzers are based on this principle.
- the beads are usually supplied in aqueous solutions and stored until use.
- the object of the invention is to provide a particularly simple, automated system for quantitative, i. H. to enable or provide the most complete possible transfer of a small volume of liquid from a storage vessel into a reaction vessel.
- the object according to the invention is achieved by the storage vessel according to the invention, the magazine according to the invention with a storage vessel according to the invention and the method according to the invention.
- a pressure-tight storage vessel which contains a liquid and has an elongate base body which is rotationally symmetrical to an axis of symmetry and which at least partially or in sections forms a rotationally symmetrical cavity in which the liquid essentially or for the most part is recorded.
- the cavity is preferably circular-cylindrical or a conical-cylindrical cavity.
- the base body is closed off on its underside by a floor and also has an opening on its upper side, which is closed in a pressure-tight manner by a closure.
- the base body has a plurality of reinforcement elements lying on the outside of the base body, which extend parallel to the axis of symmetry of the base body and which are arranged rotationally symmetrically around the axis of symmetry of the base body, so that respective wall sections of the base body that are exposed from the outside are formed between adjacent reinforcement elements and wherein the nature of the exposed wall sections allows a pressure-closing piercing by at least two hollow needles, wherein the nature of the exposed wall sections allows a pressure-closing piercing by at least two hollow needles, wherein the base body has no separating seam and no sprue residues on the exposed wall sections for piercing the needles, wherein the closure of the storage vessel is a foil, which is attached to the border by means of a melting process, the base body on the underside of the base body having a Has recess, and wherein the base body and the reinforcing elements are made in one piece by means of an injection molding process made of plastic, preferably made of polyethylene, particularly
- the storage vessel is preferably steam-tight, watertight and pressure-tight at an internal pressure of up to 2 bar.
- the nature of the exposed wall sections allows a pressure-closing puncture by at least two hollow needles in such a way that when the hollow needles have been pierced, the puncture points are pressure-tight in such a way that no liquid escapes between the wall sections and the hollow needles when the internal pressure in the capillary is up to 2 bar is present.
- the base body is preferably rotationally symmetrical to the axis of symmetry of the base body in the longitudinal direction.
- the reinforcement elements are in particular arranged rotationally symmetrically to the axis of symmetry of the base body and also point-symmetrically to the center point of the axis of symmetry of the base body.
- the axis of symmetry of the base body preferably extends in the longitudinal direction of the base body.
- the reinforcement elements are stretched longitudinally, preferably in the longitudinal direction of the storage vessel.
- the reinforcement elements are preferably so-called ribs, which rest on the outside of the base body.
- the reinforcement elements are preferably longitudinally stretched ribs with a material thickness which is greater by at least a factor of 2 than a wall thickness or material thickness of the wall sections.
- the reinforcing elements preferably have a length which is at least 70% of the length of the base body.
- the reinforcing elements are preferably arranged rotationally symmetrically to the axis of symmetry based on one or more rotations of the capillary around the axis of symmetry by a specific angle, the specific angle being in particular 360° divided by the number of reinforcing elements.
- the storage vessel is essentially rotationally symmetrical in relation to a rotation of the storage vessel around the axis of symmetry of the storage vessel by a specific angle, which is in particular 360° divided by the number of reinforcing elements.
- the storage vessel is in particular rotationally symmetrical about the axis of symmetry of the storage vessel in the longitudinal direction.
- the reinforcing elements are arranged rotationally symmetrically around the axis of symmetry of the base body in one of the ways described above makes it possible for the storage vessel to be gripped from the outside by one or more gripping elements for the purpose of automated processing, with the storage vessel not only fits into such a gripping system in a single specific position but in a plurality of positions.
- the storage vessel when using four reinforcement elements and thus four different rotational systems about the axis of symmetry of the base body or the axis of symmetry of the storage vessel, it is irrelevant for the purpose of automation which of these four positions the storage vessel occupies.
- a storage vessel according to the invention is provided in an automation step and this storage vessel is to be fed to a gripping system so that the gripping system is then to grip the storage vessel and also hold it, for example for a step of piercing hollow needles, then a previously occurring sorting step or In the course of the automation, no attention is paid to which of the several positions in which the storage container is supplied or presented to the gripper.
- wall sections of the base body that are exposed from the outside are also formed between adjacent reinforcement elements, the desired piercing of the hollow needles into these exposed wall sections can take place, so that the wall sections can be dimensioned with regard to their wall thickness in such a way that the wall thickness or the Wall is easy enough to pierce for the hollow needles.
- the overall mechanical stability of the storage vessel does not have to be brought about solely by dimensioning these wall sections or the wall thickness, but can be ensured by dimensioning the reinforcing elements. The amount of force required to pierce a hollow needle through a wall section can thus be minimized without reducing the overall mechanical stability or robustness of the storage vessel too much. It is then possible to ensure mechanical stability of the storage vessel, in particular with regard to forces occurring during a gripping process by a gripper, by dimensioning the reinforcement elements.
- the reinforcement elements are located on the outside of the base body, it is also possible to provide the cavity for receiving the liquid without forming additional mechanical elements located in the cavity, such as supporting elements running through the cavity. If such a support element were to be provided within the cavity, such a mechanical element would in turn prevent the flushing liquid from flowing through the cavity and thus reduce the effectiveness of expelling the liquid; so residual volumes of the liquid could remain in the storage vessel, which is undesirable.
- the base body and the reinforcement elements of the storage vessel are manufactured in one piece by means of an injection molding process. This has the advantage that a homogeneity of the material can be guaranteed for the stability of the storage vessel.
- the respective exposed wall sections preferably have the same wall thickness. Particularly preferably, the respective exposed wall sections have a respective equal and constant wall thickness in the longitudinal direction of the base body.
- This has the advantage that a mechanical behavior or a force behavior when one or more hollow needles pierce a corresponding wall section is the same for all wall sections, so that a processing step for puncturing a hollow needle into a wall section is independent of a rotation of the storage vessel about the axis of symmetry of the vessel for certain preferred locations.
- Such preferred positions result from those positions which are present as described above, taking into account the corresponding angles.
- the base body and the reinforcement elements of the storage vessel are produced in one piece by means of an injection molding process from plastic, preferably from polyethylene, particularly preferably high-density polyethylene.
- the plastic is a polyethylene
- the wall sections are soft enough to pierce one or more hollow needles without a wall section threatening to break or particles being detached from the wall section and introduced into the liquid . This prevents such particles from getting into the liquid and possibly even clogging those hollow needles through which the rinsing liquid is to be expelled from the storage vessel.
- high-density polyethylene also has the advantage that this plastic is compatible with the requirements of laboratory use for processing biological samples.
- plastic as high-density polyethylene has the particular advantage that such a plastic has a particularly high tear resistance and stability and can therefore be produced and processed in very thin thicknesses. In this way, a particularly thin or small wall thickness of a wall section or wall sections can then be made, so that the wall sections can be pierced even more easily.
- polyethylene has the advantage that this plastic is compatible with the requirements of laboratory use for processing biological samples.
- the base body has no separating seam and no sprue residues on the exposed wall sections for piercing the needles.
- Such seams or residues are common material artifacts of an injection molding process. Due to the fact that such artefacts are not present on the exposed wall sections, a homogeneity of the material of the wall sections and thus also a mechanical stability of these wall sections is realized. Furthermore, it can be ensured in this way that the insertion of hollow needles into the wall sections can take place with an expenditure of force which is not dependent on whether a wall section has a corresponding material artifact from an injection molding process.
- the base is preferably curved from the lowest point of the base towards the inner wall of the base body.
- the base is particularly preferably curved upwards from the lowest point of the base towards the inner wall of the base body.
- the base body preferably has an essentially constant surface roughness on its inside, in particular an average peak-to-valley height of less than 0.8 Rz, particularly preferably less than 0.4 Rz.
- a surface roughness selected in the manner described here improves or facilitates the flow of particles or beads on the inside of the base body, so that particles or beads of the liquid are less likely to remain in the storage vessel.
- the base body has a recess on the underside of the floor.
- This has the advantage that in this recess there is a position or a location at which material can be sprayed on in an injection molding process or can be introduced into an injection molding tool. If a material artifact then occurs in this recess, such as a sprue residue, then this material artifact does not protrude beyond the underside of the base, but rather remains in the recess.
- the wall thickness of the exposed wall sections is preferably more than 0.15 mm, preferably more than 0.2 mm. By choosing the wall thickness in the manner described here, a minimum stability of the wall sections for the piercing of the needles is achieved guaranteed.
- the wall thickness of the reinforcement elements is preferably at least 0.5 mm, more preferably at least 0.8 mm, most preferably at least 1 mm.
- the respective wall sections preferably have the same wall width between two reinforcing elements delimiting a respective wall section.
- the storage vessel has on its upper side a border surrounding the opening of the base body, which is spaced apart from an outer edge of the opening by a distance.
- the spacing is preferably at least 0.01 mm, particularly preferably 0.05 mm.
- the border is preferably at least 0.2 mm high.
- the closure of the storage vessel is a film which is applied or fastened to the border by means of a melting process.
- the border has the advantage that it can serve as a base for the film, although it is possible for the shape of the edge to change when the film melts. If the edge becomes too wide during the melting process, this can lead to the edge widening in the direction of the axis of symmetry of the storage vessel and expanding in this direction over the outer edge of the opening of the base body, which can form a so-called undercut, which forming the overhanging material of the rim and overlying the foil over the outer edge of the opening. In such an undercut, volumes of liquid, but also particles or beads of the liquid, can then be held back during the flushing process.
- the fact that the outer edge is preferably at a distance from the opening ensures that such an undercut does not form even during a melting process.
- the liquid is preferably an inhomogeneous liquid phase, preferably an aqueous solution comprising beads.
- the liquid is a homogeneous liquid phase, preferably comprising a biological or chemical agent in aqueous solution or liquid sample, more preferably a blood sample, most preferably serum.
- the reinforcing elements preferably have a material thickness which is at least twice as great as the wall thickness of the exposed wall sections. This ensures a minimum mechanical stability of the storage vessel.
- the storage elements preferably have a material thickness which is at most four times greater than the wall thickness of the exposed wall sections. This is advantageous in injection molding processes for jointly producing the base body and the reinforcing elements in one piece, since if the differences in the material thicknesses are too large, the plastic material in the mold or in the injection molding tool cannot otherwise flow reliably for all volume areas within the tool or within the mold can.
- the liquid is an inhomogeneous liquid phase, preferably an aqueous solution comprising solids such as particles or beads.
- inhomogeneous liquid phase preferably means that the liquid phase has at least one other component in a separate phase in addition to a liquid main component, for example another liquid which does not mix with the liquid main component, or a solid.
- the liquid is a homogeneous liquid phase, preferably comprising a biological or chemical agent in aqueous solution or liquid sample, more preferably a blood sample, most preferably serum.
- the homogeneous liquid phase is preferably human or animal samples, e.g. B. blood, preferably blood serum, urine, liquor, saliva or sweat.
- liquid means a substance or a substance mixture which consists of at least 10, preferably 20, 30, 40, 50, 75 percent by weight of a liquid at 20° C. and under atmospheric pressure , which, however, can be inhomogeneous, in particular in that it contains solids.
- the liquid is liquid, but can also be stored in the frozen state in the storage vessel.
- the storage vessel is preferably predominantly filled with liquid, i.e. at least 75, 80, 90 or 95%, for example.
- the gas phase can consist of air or can comprise a chemically inert protective gas, for example argon or nitrogen.
- the volume of the storage vessel can be less than 100 ⁇ l, more preferably less than 50 ⁇ l, even more preferably less than 45 ⁇ l, most preferably less than 35 ⁇ l.
- the volume of the storage vessel can be 25 ⁇ l in one embodiment.
- the liquid can be a solution of biological or chemical agents, or a sample of human or animal origin containing a reactant to be detected. It is particularly preferably a sample comprising a body fluid selected from the group comprising serum, urine, liquor or saliva or a dilution or processed form thereof. Alternatively, it can be a sample from food, beverages, drinking or bathing water, stool, soil material or similar.
- the sample is preferably processed in a suitable manner after collection, for example in the case of a blood sample by centrifuging off the insoluble components of the blood, and/or preserved.
- the liquid can preferably have an inhomogeneous phase and either comprise two immiscible or only partially miscible liquids or a solid substance in a liquid.
- the liquid is beads in an aqueous solution.
- Such beads may have biological reagents immobilized thereon, e.g. B. as antigen functioning polypeptides.
- Various beads are commercially available for numerous applications, mostly based on carbohydrate (e.g. agarose) or plastic. They contain active or activatable chemical groups such as carboxyl groups that can be used for the immobilization of reagents, e.g. B. of antibodies or antigens.
- the beads are preferably beads with an average diameter of 0.2 ⁇ m to 5 mm, 0.5 ⁇ m to 1 mm, 0.75 ⁇ m to 100 ⁇ m or 1 ⁇ m to 10 ⁇ m.
- the beads can be coated with an antigen that binds to a diagnostically relevant antibody, or with affinity ligands such as biotin or glutathione.
- the liquid preferably comprises the beads in the form of a aqueous suspension with a bead content of 10 to 90%, more preferably 20 to 80, more preferably 30 to 70, even more preferably 40 to 60% (w/w).
- the beads are paramagnetic, which can easily be concentrated on a surface with the aid of a magnet.
- commercially available paramagnetic beads usually contain a paramagnetic mineral, such as iron oxide.
- aqueous liquid phase Regardless of the state of homogeneity, it is preferably an aqueous liquid phase.
- This can contain additives suitable for preservation, such as ethanol or azide, or stabilizers such as pH buffers, glycerol or salts in physiological concentrations, for example to stabilize biological or chemical agents.
- a suitable buffer is, for example, 10 mM sodium phosphate, 150 mM sodium chloride, 50% glycerol, and 0.02% (w/v) sodium azide, pH 7.4.
- FIG 1 shows the basic principle known from the prior art, in which a rinsing liquid SF is introduced into the storage vessel from a rinsing reservoir SR, preferably via a pump P, by means of a hose S1 and a hollow needle N1 pierced into a storage vessel V.
- a liquid FL already present in the storage vessel V is flushed out by the flushing liquid SG via a further hollow needle N2 and a further hose S2 to a reagent vessel RG.
- a rinsing liquid SF is introduced into the storage vessel from a rinsing reservoir SR, preferably via a pump P, by means of a hose S1 and a hollow needle N1 pierced into a storage vessel V.
- a liquid FL already present in the storage vessel V is flushed out by the flushing liquid SG via a further hollow needle N2 and a further hose S2 to a reagent vessel RG.
- the figure 2 shows a preferred embodiment of a storage vessel V, which contains a liquid.
- the liquid FL is in detail in figure 5 shown.
- the storage vessel V is in a lateral position.
- the storage vessel V has wall sections W of a base body G and reinforcement elements VE resting on the base body G.
- the base body G has an opening OF, which is delimited at the top by a peripheral border UR.
- the storage vessel V is manufactured in one piece by means of an injection molding process.
- the storage vessel V is preferably made of polyethylene, particularly preferably made of high-density polyethylene.
- the base body G and the reinforcement elements VE are produced in one piece by means of an injection molding process, with the wall sections W having no separating seams and also no sprue residues.
- the figure 3 once again shows the storage vessel V in an upright position.
- the storage vessel V is shown from its top. So-called gripping elements G1, G2, which can be brought up to the storage vessel V from corresponding directions R1, R2 in order to grip the storage vessel V, are shown schematically. Due to the rotational symmetry of the storage vessel V and also the rotationally symmetrical arrangement of the reinforcement elements VE, better visible in FIG figure 2 , gripping the storage vessel V is possible in different positions.
- the storage vessel V has four reinforcement elements VE, so that, as in FIG figure 4 evident, four different positions related to a rotation of the storage vessel about the axis center point MP of the symmetry axis of the storage vessel or the symmetry axis of the base body result, in which the storage vessel V can be gripped in the same way.
- the storage vessel V does not have to be clearly aligned in a single position in relation to a rotation about the center point MP of the axis of symmetry of the storage vessel or axis of symmetry of the base body; it is only sufficient if it is in one of the several positions occupies, in which the storage vessel can be gripped by the gripping elements G1, G2 in the same way.
- the storage vessel is therefore rotationally symmetrical with respect to its axis of symmetry by an angle which is 360° divided by the number of reinforcing elements.
- the reinforcement elements VE are preferably longitudinally stretched ribs with a material thickness which is greater by at least a factor of 2 than a wall thickness or material thickness of the wall sections W.
- the figure 5 shows the storage vessel in a sectional view along an axis between the points A from FIG figure 3 .
- the storage vessel V has a section which forms a base body G on which the reinforcing elements VE from the figure 2 issue.
- the base body G is rotationally symmetrical in relation to the axis of symmetry SA.
- the base body G forms at least partially or at least in sections a rotationally symmetrical cavity H, in which the liquid FL is at least partially or essentially received, in particular for the most part.
- the cavity H is preferably circular-cylindrical or a conical-cylindrical cavity.
- the base body G is closed off on its underside U by a base B and on its upper side O the base body G has an opening OF.
- the opening is closed in a pressure-tight manner by a closure VS, in particular indirectly, since the closure VS is applied to a border UR of the opening OF.
- the closure VS is preferably a lid made of plastic or aluminum.
- the closure VS is a foil, in particular comprising an aluminum foil, particularly preferably in the form of an aluminum foil for melting onto plastic, such as the border UR.
- the film VS is preferably a multilayer film with a first film layer made of aluminum, a subsequent adhesive film layer based on polyurethane and a further subsequent film layer comprising linear low-density polyethylene (LLDPE).
- the wall sections W have the same wall thickness WS, which is preferably between 0.2 and 0.3 mm.
- the reinforcement elements VE are arranged on the base body G in such a way that respective wall sections W of the base body G that are exposed from the outside are formed between adjacent reinforcement elements VE.
- the nature of the exposed wall sections W permits puncture by at least two hollow needles to seal off the pressure.
- the base body G is closed off by the bottom B on its underside U.
- the bottom B is shown again in detail E2 in FIG figure 7 shown in more detail, which also shows that the deepest point TP of the bottom B towards the inner wall I, shown in the figure 5 , is arched, especially arched upwards.
- the base body On the underside U, the base body has a recess AN, at which, for example, material artifacts are tolerable, such as sprue residues, so that below the underside plane UE no material protrudes downward beyond this underside plane UE.
- material artifacts are tolerable, such as sprue residues, so that below the underside plane UE no material protrudes downward beyond this underside plane UE.
- the inside IS of the base body also has an essentially constant surface finish, in particular an average peak-to-valley height of less than 0.8 Rz, particularly preferably less than 0.5 Rz, very particularly preferably 0.4 Rz.
- the figure 5 also shows two gripping elements G1' and G2', which preferably engage in the guide grooves FR in order to hold the storage vessel V.
- the figure 6 shows the storage vessel V from the underside, the material thickness MS of the reinforcement element VE being shown, in this case, for example, 1 mm.
- the respective wall sections W between two reinforcing elements VE delimiting a respective wall section W have the same wall width WAB, in particular in a plane which is perpendicular to the axis of symmetry or longitudinal axis of symmetry of the base body.
- the figure 8 shows the detail E1 from FIG figure 5 .
- the opening OF is surrounded by a border UR or a corresponding sealing edge SIR or towards the outside framed.
- the border UR is preferably what is known as a sealing edge SIR, onto which a foil can be sealed by means of a melting process, so that the foil then serves as a closure for the storage vessel.
- This border UR or the crater edge UR is used to apply a closure in the form of a film VS, FO by melting it onto the edge U or the crater edge U.
- This border UR or the sealing edge SIR is spaced from an outer edge R of the opening OF by a distance ABM.
- This spacing ABM is preferably at least 0.01 mm, particularly preferably at least 0.05 mm.
- the closure VS is preferably a cover made of plastic or aluminum.
- the closure is a film.
- the foil is preferably a plastic foil or an aluminum foil.
- the thickness of the film can be 5 ⁇ m to 5 mm, preferably 10 ⁇ m to 1 mm, more preferably 25 ⁇ m to 250 ⁇ m.
- the film VS is preferably a multilayer film with a first film layer made of aluminum, a subsequent second, adhesive film layer based on polyurethane and a further subsequent, third film layer comprising linear low-density polyethylene (LLDPE).
- the first film layer preferably has a thickness of 35 microns.
- the second film layer preferably has a density of 4 grams/square meter.
- the third film layer preferably has a thickness of 23 microns.
- the storage vessel has an internal height H and its internal base has a diameter D and the ratio of D to H is at least 1:2, more preferably 1:5, even more preferably 1:10.
- the storage vessel has a base or inner base and an inner height H, by which is meant the base that is geometrically accessible to the liquid contained or the height of the side wall that is accessible to the liquid.
- the vessel preferably has the highest possible ratio of internal height to internal base, measured in the form of its internal diameter D, so that the internal base area for the absorption of sedimented substances on the base is as small as possible.
- the ratio of D to H is preferably at least 1:2, 1:2.5, 1:3, 1:4, 1:5, 1:7.5, 1:10, 1:15 or 1:20, where the longitudinal axis runs along the longer side and has two ends. At one of the ends is the top.
- the upper side is preferably at the end which is at the top when the storage vessel is in use, given the orientation predetermined by the shape of the storage vessel.
- the base body is designed in such a way that in the area of the exposed wall sections it allows the pressure-closing insertion of two hollow needles, which are preferably ground stainless steel tube sections.
- Their outer diameter is preferably 0.5 to 5 mm, particularly preferably 1 mm, and their inner diameter is 0.1 to 3 mm, particularly preferably 0.2 to 0.7 mm, with the proviso that the inner diameter is smaller than the outer diameter is preferably 0.4 mm.
- a hollow needle in particular has a fixed, closed tip for penetrating the wall section and also has a diameter of 1 mm.
- Each aperture preferably has a circular cross-sectional area with a diameter which is preferably in the range 0.2 to 0.3mm, more preferably 0.28mm.
- the storage vessel is considered to be pressure-tight if the introduction of 1 ml of water into the completely filled storage vessel over 100 seconds via a hollow needle inserted after the pressure has been applied causes at least 750, preferably 950, even more preferably 990 ⁇ l of water to escape in the same time via a second hollow needle of the same design that is finally inserted into the pressure.
- the puncture is preferably performed as pressure-sealing if the storage vessel remains pressure-tight when the inserted hollow needle is closed.
- the diameter of the hollow needles must be dimensioned in such a way that any solids contained in the liquid, such as beads, cannot clog the needles.
- both needles are connected in parallel arrangement at least over the longitudinal axis with the same orientation, e.g. B. by soldering together two hollow metal needles, or in the form of a coaxial needle.
- the first hollow needle has a smaller diameter than the second hollow needle and is arranged concentrically in its interior, the first hollow needle being longer than the second and protruding far enough out of its outlet opening that a short circuit does not occur. If the first and second hollow needles are connected to one another with a parallel arrangement and the same orientation, they can advantageously be inserted into the storage vessel together.
- the reinforcement elements VE and the base body G extend as far as the underside U of the storage vessel V.
- the reinforcement elements VE together with the base body G form guide grooves FR, which Underside U of the body G are open.
- This guide grooves FR are again in the figure 5 registered or drawn in as well as in the figure 6 .
- the storage jar off figure 2 has a shoulder AB on its upper side O, which delimits the guide grooves FR at the top. This paragraph can also be clearly seen in the figure 5 .
- the viewer's gaze is directed to the underside of shelf AB.
- the guide grooves FR are freely accessible from the underside U of the base body G.
- Paragraph AB is located on the top of the storage vessel at the level of the opening OF of storage vessel V.
- Paragraph AB from the figures 6 , 5 as well as 2 can also be referred to as a shoulder heel. This paragraph or shoulder paragraph AB delimits the guide grooves FR at the top or closes them off.
- the reinforcement elements VE are preferably elongated ribs which run from the underside of the storage vessel to the shoulder on the top of the storage vessel.
- the reinforcement elements VE do not protrude beyond a base area of the top side of the storage vessel, in particular when viewed from above on the top side of the storage vessel, as can be seen from the top view in figure 4 evident.
- the figure 9 shows an oblique view of a proposed magazine M, which has at least one magazine channel MK.
- the magazine channel MK is accessible from the top OM of the magazine and from the bottom UM of the magazine.
- FIG 10 shows the magazine M in a side view, in which two magazine channels MK are visible because a part of a side wall is hidden.
- a magazine K preferably has a mechanically flexible or elastically deformable snap hook
- the snap hook SH in the upper area of the magazine channel, via which a supply of storage vessels into a magazine channel MK can be controlled.
- the snap hook SH holds back storage vessels located in the magazine channel MK, particularly in the event that the magazine M is held upside down.
- the figure 12 shows a view of the magazine M from above, in which the snap hook SH is also visible in the area of the magazine channel.
- the figure 13 shows the magazine M from below.
- the snap hook SH is also visible from below through the magazine channel MK.
- a retaining element or latching element RE is also visible, as well as a guide element FE.
- the figure 14 shows the magazine channel MK again in a sectional view of a section AA from FIG figure 13 .
- the guide element FE and the locking element RE are also visible on the underside UM of the channel MK or the magazine M.
- the magazine channel MK runs straight through the magazine M.
- the Figure 11a shows a magazine M with several storage vessels V in a magazine channel MK.
- a bottom storage vessel V is held back in the magazine MK by a retaining element RE.
- the mechanically flexible retaining element RE engages in the magazine channel MK in its rest position. In this first position, the paragraph AB of the storage vessel V comes to rest on the retaining element RE.
- the Figure 11c shows the storage vessel V in the same first position in a sectional view of the magazine from a perspective which is opposite to the perspective of FIG Figure 11b is rotated by 90° about the axis of symmetry of the magazine channel or by 90° about the axis of symmetry of the storage vessel V.
- the retaining element RE preferably engages in one of the guide grooves FR.
- the storage vessel V is retained in the first position, in particular despite its weight, in the magazine channel MK by the retaining element RE, in particular in such a way that the storage vessel V in the first position does not protrude with its underside U from the magazine channel MK.
- the retaining element RE is deflected by the shoulder AB.
- the retaining element RE is at least partially deflected out of the magazine channel MK, so that the shoulder receiving area or the storage container V can pass the retaining element RE, as is then the case in a further position in the Figure 19a is drawn.
- the figure 15 shows a detail Z from the figure 13 , in which the position of the restraining element RE can be seen more precisely.
- the retaining element RE and the guide element FE interact in a special way, as will now be described below.
- FIG. 17a shows a magazine M with storage vessels V located therein, the retaining element RE and the guide element FE being visible from the underside.
- An enlargement of this view for a section is in the Figure 17b shown.
- the Figure 16a shows the magazine M with storage vessels V again from the bottom UM of the magazine, where in the Figure 16b the retaining element RE is shown again for an enlarged area and in FIG Figure 16c the guide element FE.
- the guide element FE is also clearly visible in the figures 15 and 14 .
- the two views or perspectives are rotated relative to one another by 90° about the axis of symmetry of the magazine channel or by 90° about the axis of symmetry of the storage vessel V.
- the guide element FE is provided in the lower area of the magazine channel MK at a second height H2 below the first height H1 of the retaining element RE, as can be seen from FIGS Figures 18a and B becomes clearly evident.
- Figure 18a shows a sectional view in which the retaining element RE is visible in a first position, while a corresponding view from FIG Figure 18b shows a sectional view when the storage vessel is rotated by 90° about the axis of symmetry, in which the guide element FE becomes visible.
- the guide element FE is a mechanically flexible guide element.
- the guide element FE already engages in the first position of the storage vessel V from the Figures 18a and 18b into one of the guide grooves FR.
- the guide element FE rests against the reinforcement elements VE forming the guide groove FR.
- the guide element FE brings about an alignment of the storage vessel V in the magazine channel MK in a preferred position.
- the magazine channel MK can be dimensioned larger than the cross section of the storage vessel V, taking into account a certain tolerance.
- the magazine channel MK is larger in terms of its cross-sectional area than the cross-sectional area of the storage vessel V.
- the cross-sectional area of the storage vessel runs perpendicular to the axis of symmetry of the storage vessel in the longitudinal direction.
- the magazine channel MK has a cross-sectional area which is dimensioned in such a way that the storage vessel cannot be rotated by more than 5 degrees about its axis of symmetry or longitudinal axis of symmetry.
- each magazine channel MK has a cross-sectional area which is dimensioned such that the storage vessel or its longitudinal axis of symmetry cannot be tilted by more than 5 degrees relative to the magazine channel MK.
- FIGS. 19a and 19b show the storage vessel in a second position, in which the storage vessel V protrudes with its underside U from the magazine channel MK.
- the storage vessel V protrudes from the magazine channel MK with its underside U in the second position, the storage vessel is accessible at least in part for a gripping unit outside of the magazine channel, so that such a gripping unit can then reach the storage vessel due to the guidance by the guide element FE V can be expected at a certain location or in a certain position.
- a gripping unit can then preferably engage in the guide grooves by means of gripping elements.
- the guide element FE is deflected by a further application of a force to the upper side O of the storage vessel V and is at least partially deflected out of the magazine channel.
- the guide element FE is also designed in particular in such a way that after the step AB has been passed past the guide element FE, the guide element FE returns to its rest position.
- the combination of guide element FE and retaining element RE allows the proposed magazine M to be equipped with storage vessels V or a plurality of storage vessels V in a magazine channel and for the magazine M to be placed with its underside UM, for example, on a table or another Possibility of parking can be parked without a storage vessel being damaged from its underside.
- the guide element FE ensures that the storage vessel V protrudes from the magazine channel MK in the specific spatial position. Due to the mechanical flexibility of the foot element FE, this guide element FE returns to a rest position, even after fulfilling its function of spatially positioning a storage vessel V, in which it can engage in a guide groove FR of a further storage vessel V immediately or later. There is thus a particularly advantageous interaction between the guide grooves FR, which are formed by the reinforcement elements VE and the base body and are open towards the bottom, of the storage containers V and of the guide element FE and the retaining element RE.
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- Chemical Kinetics & Catalysis (AREA)
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- Analytical Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Hematology (AREA)
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- Sampling And Sample Adjustment (AREA)
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Priority Applications (9)
Application Number | Priority Date | Filing Date | Title |
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PL18215204.1T PL3669981T3 (pl) | 2018-12-21 | 2018-12-21 | Uszczelniony ciśnieniowo pojemnik zasobnikowy, zawierający ciecz |
PT182152041T PT3669981T (pt) | 2018-12-21 | 2018-12-21 | Recipiente de armazenamento à prova de pressão contendo um líquido |
EP18215204.1A EP3669981B1 (de) | 2018-12-21 | 2018-12-21 | Druckdichtes vorratsgefäss enthaltend eine flüssigkeit |
BR102019025839-0A BR102019025839A2 (pt) | 2018-12-21 | 2019-12-06 | Reservatório à prova de pressão contendo um líquido |
US16/718,547 US11814196B2 (en) | 2018-12-21 | 2019-12-18 | Pressure-tight storage vessel containing a liquid |
JP2019228807A JP7215991B2 (ja) | 2018-12-21 | 2019-12-19 | 液体を収容する耐圧保存容器 |
SG10201912830YA SG10201912830YA (en) | 2018-12-21 | 2019-12-20 | Pressure-tight storage vessel containing a liquid |
CA3065877A CA3065877C (en) | 2018-12-21 | 2019-12-20 | Pressure-tight storage vessel containing a liquid |
CN201911321362.XA CN111348330B (zh) | 2018-12-21 | 2019-12-20 | 包含液体的压力密封的储存容器 |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
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EP18215204.1A EP3669981B1 (de) | 2018-12-21 | 2018-12-21 | Druckdichtes vorratsgefäss enthaltend eine flüssigkeit |
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EP3669981A1 EP3669981A1 (de) | 2020-06-24 |
EP3669981B1 true EP3669981B1 (de) | 2022-07-27 |
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EP18215204.1A Active EP3669981B1 (de) | 2018-12-21 | 2018-12-21 | Druckdichtes vorratsgefäss enthaltend eine flüssigkeit |
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EP (1) | EP3669981B1 (ja) |
JP (1) | JP7215991B2 (ja) |
CN (1) | CN111348330B (ja) |
BR (1) | BR102019025839A2 (ja) |
CA (1) | CA3065877C (ja) |
PL (1) | PL3669981T3 (ja) |
PT (1) | PT3669981T (ja) |
SG (1) | SG10201912830YA (ja) |
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CN112896804A (zh) * | 2021-01-15 | 2021-06-04 | 王雷 | 一种密封型药物储存瓶 |
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US4890757A (en) * | 1987-02-11 | 1990-01-02 | Robbins Edward S Iii | Ribbed container with closure |
US5560830A (en) * | 1994-12-13 | 1996-10-01 | Coleman; Charles M. | Separator float and tubular body for blood collection and separation and method of use thereof |
SE9904783D0 (sv) | 1999-12-22 | 1999-12-22 | Gambro Lundia Ab | Needle holding device |
US6599484B1 (en) * | 2000-05-12 | 2003-07-29 | Cti, Inc. | Apparatus for processing radionuclides |
TWI241184B (en) | 2004-02-06 | 2005-10-11 | Shr Ji Tau | Two-end-opened medication bottle structure and medication storage and withdrawal device comprising the medication bottle |
ES2877598T3 (es) | 2008-03-05 | 2021-11-17 | Becton Dickinson Co | Tapón perforable comoldeado y método para fabricar el mismo |
JP4303771B1 (ja) | 2008-03-13 | 2009-07-29 | 容子 中鼻 | データ保存機能を有するテストチューブ |
CN102460177B (zh) * | 2009-05-15 | 2016-02-03 | 生物梅里埃有限公司 | 用于对培养试样容器进行自动地通风和取样的系统和方法 |
CN102113887A (zh) | 2010-01-06 | 2011-07-06 | 白杰 | 一种即时真空静脉采血方法及专用设备 |
FI20105591A0 (fi) * | 2010-05-26 | 2010-05-26 | Arcdia Internat Oy Ltd | Bioaffiniteettimääritysten reaktiokyvettien sulkeminen |
US8550273B2 (en) | 2010-08-31 | 2013-10-08 | Wheaton Industries, Inc. | Cryogenic vials |
FR2972432B1 (fr) | 2011-03-10 | 2014-06-13 | Bio Rad Pasteur | Receptacle de type carte gel muni d'un opercule comportant une predecoupe |
US20130109009A1 (en) * | 2011-10-31 | 2013-05-02 | Dan W. Kessel | Biological sample preparation |
WO2014195409A1 (de) * | 2013-06-06 | 2014-12-11 | Lvl Technologies Gmbh & Co. Kg | Lasermarkierbares probenroehrchen |
EP2959971A1 (de) | 2014-06-27 | 2015-12-30 | Euroimmun Medizinische Labordiagnostika AG | Verfahren und Vorrichtung zur Überführung von Flüssigkeiten |
CN206315840U (zh) | 2016-12-29 | 2017-07-11 | 山西振东基赛生物科技有限公司 | 试管架及生物物质分离组件 |
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2018
- 2018-12-21 EP EP18215204.1A patent/EP3669981B1/de active Active
- 2018-12-21 PT PT182152041T patent/PT3669981T/pt unknown
- 2018-12-21 PL PL18215204.1T patent/PL3669981T3/pl unknown
-
2019
- 2019-12-06 BR BR102019025839-0A patent/BR102019025839A2/pt active IP Right Grant
- 2019-12-18 US US16/718,547 patent/US11814196B2/en active Active
- 2019-12-19 JP JP2019228807A patent/JP7215991B2/ja active Active
- 2019-12-20 CN CN201911321362.XA patent/CN111348330B/zh active Active
- 2019-12-20 CA CA3065877A patent/CA3065877C/en active Active
- 2019-12-20 SG SG10201912830YA patent/SG10201912830YA/en unknown
Also Published As
Publication number | Publication date |
---|---|
BR102019025839A2 (pt) | 2020-08-11 |
SG10201912830YA (en) | 2020-07-29 |
CA3065877A1 (en) | 2020-06-21 |
PL3669981T3 (pl) | 2022-11-28 |
JP7215991B2 (ja) | 2023-01-31 |
EP3669981A1 (de) | 2020-06-24 |
PT3669981T (pt) | 2022-09-05 |
CN111348330B (zh) | 2023-03-14 |
CN111348330A (zh) | 2020-06-30 |
US20200198813A1 (en) | 2020-06-25 |
US11814196B2 (en) | 2023-11-14 |
CA3065877C (en) | 2023-01-31 |
JP2020118678A (ja) | 2020-08-06 |
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