EP3661515A4 - Nouveaux inhibiteurs de braf et leur utilisation pour le traitement de réactions cutanées - Google Patents

Nouveaux inhibiteurs de braf et leur utilisation pour le traitement de réactions cutanées Download PDF

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Publication number
EP3661515A4
EP3661515A4 EP18841422.1A EP18841422A EP3661515A4 EP 3661515 A4 EP3661515 A4 EP 3661515A4 EP 18841422 A EP18841422 A EP 18841422A EP 3661515 A4 EP3661515 A4 EP 3661515A4
Authority
EP
European Patent Office
Prior art keywords
treatment
braf inhibitors
cutaneous reactions
novel braf
novel
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
EP18841422.1A
Other languages
German (de)
English (en)
Other versions
EP3661515B1 (fr
EP3661515A2 (fr
Inventor
Noa Shelach
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Lutris Pharma Ltd
Original Assignee
Lutris Pharma Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Lutris Pharma Ltd filed Critical Lutris Pharma Ltd
Priority to SI201830670T priority Critical patent/SI3661515T1/sl
Priority to HRP20220609TT priority patent/HRP20220609T1/hr
Publication of EP3661515A2 publication Critical patent/EP3661515A2/fr
Publication of EP3661515A4 publication Critical patent/EP3661515A4/fr
Application granted granted Critical
Publication of EP3661515B1 publication Critical patent/EP3661515B1/fr
Active legal-status Critical Current
Anticipated expiration legal-status Critical

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D473/00—Heterocyclic compounds containing purine ring systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
    • A61K31/52—Purines, e.g. adenine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0014—Skin, i.e. galenical aspects of topical compositions
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/10—Anti-acne agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/10—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing aromatic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Dermatology (AREA)
  • Epidemiology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicinal Preparation (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
EP18841422.1A 2017-07-29 2018-07-26 Nouveaux inhibiteurs de braf et leur utilisation pour le traitement de réactions cutanées Active EP3661515B1 (fr)

Priority Applications (2)

Application Number Priority Date Filing Date Title
SI201830670T SI3661515T1 (sl) 2017-07-29 2018-07-26 Novi BRaf inhibitorji in njihova uporaba za zadravljenje kožnih reakcij
HRP20220609TT HRP20220609T1 (hr) 2017-07-29 2018-07-26 Novi braf inhibitori i njihovo korištenje za tretiranje kožnih reakcija

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201762538675P 2017-07-29 2017-07-29
PCT/IL2018/050836 WO2019026065A2 (fr) 2017-07-29 2018-07-26 Nouveaux inhibiteurs de braf et leur utilisation pour le traitement de réactions cutanées

Publications (3)

Publication Number Publication Date
EP3661515A2 EP3661515A2 (fr) 2020-06-10
EP3661515A4 true EP3661515A4 (fr) 2021-01-06
EP3661515B1 EP3661515B1 (fr) 2022-02-23

Family

ID=65233550

Family Applications (1)

Application Number Title Priority Date Filing Date
EP18841422.1A Active EP3661515B1 (fr) 2017-07-29 2018-07-26 Nouveaux inhibiteurs de braf et leur utilisation pour le traitement de réactions cutanées

Country Status (15)

Country Link
US (3) US10927112B2 (fr)
EP (1) EP3661515B1 (fr)
JP (1) JP6912667B2 (fr)
KR (1) KR102328351B1 (fr)
CN (1) CN111132680B (fr)
AU (1) AU2018311538B2 (fr)
BR (1) BR112020001935A2 (fr)
CA (1) CA3070542C (fr)
DK (1) DK3661515T3 (fr)
ES (1) ES2908602T3 (fr)
HR (1) HRP20220609T1 (fr)
IL (1) IL272312B (fr)
SI (1) SI3661515T1 (fr)
WO (1) WO2019026065A2 (fr)
ZA (1) ZA202000354B (fr)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US11458139B2 (en) * 2017-08-08 2022-10-04 Memorial Sloan Kettering Cancer Center Use of BRAF inhibitors for treating cutaneous reactions caused by treatment with a MEK inhibitor
RS64618B1 (sr) 2019-02-12 2023-10-31 Lutris Pharma Ltd Upotreba lokalnih kompozicija braf inhibitorа za lečenje radijacijskog dermatitisa
CN116669739A (zh) * 2020-12-24 2023-08-29 鲁特里斯制药有限公司 用于治疗egfr下游效应物诱导的反应的局部braf抑制剂组合物
EP4362949A2 (fr) * 2021-07-02 2024-05-08 Lutris Pharma Ltd. Utilisation d'isoquinoléine-1,5-diamines pour la cicatrisation de plaies

Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2007076092A2 (fr) * 2005-12-23 2007-07-05 Amgen Inc. Composes d'heteroaryle bicycliques azotes et procedes d'utilisation
US8557830B2 (en) * 2007-06-07 2013-10-15 Amgen Inc. RAF kinase modulators and methods of use
WO2015171833A1 (fr) * 2014-05-06 2015-11-12 The Regents Of The University Of California Cicatrisation de plaie au moyen d'inhibiteurs de braf
WO2017154001A1 (fr) * 2016-03-10 2017-09-14 Lutris Pharma Ltd. Utilisation d'inhibiteurs de braf pour le traitement de réactions cutanées

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5753612A (en) 1992-10-27 1998-05-19 Yissum Research Development Co. Of The Hebrew University Of Jerusalem Pharmaceutical composition and method for inhibiting hair growth by administration of activin or activin agonists
TWI611053B (zh) * 2012-02-27 2018-01-11 曾宇鳳 為先導藥物最適化之以結構為基礎的片段遷越及合成可行性之改良
KR20140011780A (ko) 2012-07-19 2014-01-29 한미약품 주식회사 단백질 키나아제 저해활성을 갖는 이소퀴놀린-5-카복스아미드 유도체

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2007076092A2 (fr) * 2005-12-23 2007-07-05 Amgen Inc. Composes d'heteroaryle bicycliques azotes et procedes d'utilisation
US8557830B2 (en) * 2007-06-07 2013-10-15 Amgen Inc. RAF kinase modulators and methods of use
WO2015171833A1 (fr) * 2014-05-06 2015-11-12 The Regents Of The University Of California Cicatrisation de plaie au moyen d'inhibiteurs de braf
WO2017154001A1 (fr) * 2016-03-10 2017-09-14 Lutris Pharma Ltd. Utilisation d'inhibiteurs de braf pour le traitement de réactions cutanées

Non-Patent Citations (4)

* Cited by examiner, † Cited by third party
Title
ADRIAN L. SMITH ET AL: "Selective Inhibitors of the Mutant B-Raf Pathway: Discovery of a Potent and Orally Bioavailable Aminoisoquinoline", JOURNAL OF MEDICINAL CHEMISTRY, vol. 52, no. 20, 22 October 2009 (2009-10-22), pages 6189 - 6192, XP055510660, ISSN: 0022-2623, DOI: 10.1021/jm901081g *
J. CARNAHAN ET AL: "Selective and Potent Raf Inhibitors Paradoxically Stimulate Normal Cell Proliferation and Tumor Growth", MOLECULAR CANCER THERAPEUTICS, vol. 9, no. 8, 27 July 2010 (2010-07-27), US, pages 2399 - 2410, XP055331626, ISSN: 1535-7163, DOI: 10.1158/1535-7163.MCT-10-0181 *
JOSETTE CARNAHAN: "Selective and Potent Raf Inhibitors Paradoxically Stimulate Normal Cell Proliferation and Tumor Growth - Supplementary Data", MOLECULAR MEDICINE IN PRACTICE, vol. 9, no. 8, 1 January 2010 (2010-01-01), pages 1 - 12, XP055753549 *
XIAOLUN WANG ET AL: "Conformation-Specific Effects of Raf Kinase Inhibitors", JOURNAL OF MEDICINAL CHEMISTRY, vol. 55, no. 17, 13 September 2012 (2012-09-13), pages 7332 - 7341, XP055290992, ISSN: 0022-2623, DOI: 10.1021/jm300613w *

Also Published As

Publication number Publication date
AU2018311538B2 (en) 2021-03-25
JP2020528933A (ja) 2020-10-01
JP6912667B2 (ja) 2021-08-04
KR102328351B1 (ko) 2021-11-19
BR112020001935A2 (pt) 2020-07-28
RU2020108782A3 (fr) 2021-09-02
CN111132680B (zh) 2022-02-08
US10927112B2 (en) 2021-02-23
CA3070542C (fr) 2021-05-18
EP3661515B1 (fr) 2022-02-23
WO2019026065A2 (fr) 2019-02-07
AU2018311538A1 (en) 2020-02-13
ES2908602T3 (es) 2022-05-03
US20220274988A1 (en) 2022-09-01
ZA202000354B (en) 2024-01-31
HRP20220609T1 (hr) 2022-06-24
KR20200035990A (ko) 2020-04-06
RU2020108782A (ru) 2021-09-02
US11339163B2 (en) 2022-05-24
EP3661515A2 (fr) 2020-06-10
DK3661515T3 (da) 2022-04-19
CA3070542A1 (fr) 2019-02-07
SI3661515T1 (sl) 2022-06-30
WO2019026065A3 (fr) 2019-08-01
US20190389862A1 (en) 2019-12-26
IL272312A (en) 2020-03-31
CN111132680A (zh) 2020-05-08
US20210070757A1 (en) 2021-03-11
IL272312B (en) 2021-06-30

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