EP3642571A1 - Device for packaging and dispensing a product, notably a pharmaceutical or cosmetic product - Google Patents

Device for packaging and dispensing a product, notably a pharmaceutical or cosmetic product

Info

Publication number
EP3642571A1
EP3642571A1 EP18724602.0A EP18724602A EP3642571A1 EP 3642571 A1 EP3642571 A1 EP 3642571A1 EP 18724602 A EP18724602 A EP 18724602A EP 3642571 A1 EP3642571 A1 EP 3642571A1
Authority
EP
European Patent Office
Prior art keywords
dispensing
piston
product
container
compartment
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Withdrawn
Application number
EP18724602.0A
Other languages
German (de)
French (fr)
Inventor
Jian Yan
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Galderma Research and Development SNC
Original Assignee
Galderma Research and Development SNC
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Galderma Research and Development SNC filed Critical Galderma Research and Development SNC
Publication of EP3642571A1 publication Critical patent/EP3642571A1/en
Withdrawn legal-status Critical Current

Links

Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01F—MEASURING VOLUME, VOLUME FLOW, MASS FLOW OR LIQUID LEVEL; METERING BY VOLUME
    • G01F11/00—Apparatus requiring external operation adapted at each repeated and identical operation to measure and separate a predetermined volume of fluid or fluent solid material from a supply or container, without regard to weight, and to deliver it
    • G01F11/02—Apparatus requiring external operation adapted at each repeated and identical operation to measure and separate a predetermined volume of fluid or fluent solid material from a supply or container, without regard to weight, and to deliver it with measuring chambers which expand or contract during measurement
    • G01F11/04—Apparatus requiring external operation adapted at each repeated and identical operation to measure and separate a predetermined volume of fluid or fluent solid material from a supply or container, without regard to weight, and to deliver it with measuring chambers which expand or contract during measurement of the free-piston type
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B65—CONVEYING; PACKING; STORING; HANDLING THIN OR FILAMENTARY MATERIAL
    • B65D—CONTAINERS FOR STORAGE OR TRANSPORT OF ARTICLES OR MATERIALS, e.g. BAGS, BARRELS, BOTTLES, BOXES, CANS, CARTONS, CRATES, DRUMS, JARS, TANKS, HOPPERS, FORWARDING CONTAINERS; ACCESSORIES, CLOSURES, OR FITTINGS THEREFOR; PACKAGING ELEMENTS; PACKAGES
    • B65D83/00—Containers or packages with special means for dispensing contents
    • B65D83/0005—Containers or packages provided with a piston or with a movable bottom or partition having approximately the same section as the container
    • B65D83/0038—Containers or packages provided with a piston or with a movable bottom or partition having approximately the same section as the container moved by a spring-like mechanism
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01F—MEASURING VOLUME, VOLUME FLOW, MASS FLOW OR LIQUID LEVEL; METERING BY VOLUME
    • G01F11/00—Apparatus requiring external operation adapted at each repeated and identical operation to measure and separate a predetermined volume of fluid or fluent solid material from a supply or container, without regard to weight, and to deliver it
    • G01F11/02—Apparatus requiring external operation adapted at each repeated and identical operation to measure and separate a predetermined volume of fluid or fluent solid material from a supply or container, without regard to weight, and to deliver it with measuring chambers which expand or contract during measurement
    • G01F11/04—Apparatus requiring external operation adapted at each repeated and identical operation to measure and separate a predetermined volume of fluid or fluent solid material from a supply or container, without regard to weight, and to deliver it with measuring chambers which expand or contract during measurement of the free-piston type
    • G01F11/06—Apparatus requiring external operation adapted at each repeated and identical operation to measure and separate a predetermined volume of fluid or fluent solid material from a supply or container, without regard to weight, and to deliver it with measuring chambers which expand or contract during measurement of the free-piston type with provision for varying the stroke of the piston
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01F—MEASURING VOLUME, VOLUME FLOW, MASS FLOW OR LIQUID LEVEL; METERING BY VOLUME
    • G01F11/00—Apparatus requiring external operation adapted at each repeated and identical operation to measure and separate a predetermined volume of fluid or fluent solid material from a supply or container, without regard to weight, and to deliver it
    • G01F11/10—Apparatus requiring external operation adapted at each repeated and identical operation to measure and separate a predetermined volume of fluid or fluent solid material from a supply or container, without regard to weight, and to deliver it with measuring chambers moved during operation
    • G01F11/12—Apparatus requiring external operation adapted at each repeated and identical operation to measure and separate a predetermined volume of fluid or fluent solid material from a supply or container, without regard to weight, and to deliver it with measuring chambers moved during operation of the valve type, i.e. the separating being effected by fluid-tight or powder-tight movements
    • G01F11/20—Apparatus requiring external operation adapted at each repeated and identical operation to measure and separate a predetermined volume of fluid or fluent solid material from a supply or container, without regard to weight, and to deliver it with measuring chambers moved during operation of the valve type, i.e. the separating being effected by fluid-tight or powder-tight movements wherein the measuring chamber rotates or oscillates
    • G01F11/22—Apparatus requiring external operation adapted at each repeated and identical operation to measure and separate a predetermined volume of fluid or fluent solid material from a supply or container, without regard to weight, and to deliver it with measuring chambers moved during operation of the valve type, i.e. the separating being effected by fluid-tight or powder-tight movements wherein the measuring chamber rotates or oscillates for liquid or semiliquid
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01F—MEASURING VOLUME, VOLUME FLOW, MASS FLOW OR LIQUID LEVEL; METERING BY VOLUME
    • G01F11/00—Apparatus requiring external operation adapted at each repeated and identical operation to measure and separate a predetermined volume of fluid or fluent solid material from a supply or container, without regard to weight, and to deliver it
    • G01F11/02—Apparatus requiring external operation adapted at each repeated and identical operation to measure and separate a predetermined volume of fluid or fluent solid material from a supply or container, without regard to weight, and to deliver it with measuring chambers which expand or contract during measurement
    • G01F11/021—Apparatus requiring external operation adapted at each repeated and identical operation to measure and separate a predetermined volume of fluid or fluent solid material from a supply or container, without regard to weight, and to deliver it with measuring chambers which expand or contract during measurement of the piston type
    • G01F11/024—Apparatus requiring external operation adapted at each repeated and identical operation to measure and separate a predetermined volume of fluid or fluent solid material from a supply or container, without regard to weight, and to deliver it with measuring chambers which expand or contract during measurement of the piston type the pistons reciprocating in rotatable cylinders

Definitions

  • the present invention relates to a device for packaging and dispensing a product.
  • the device is particularly suitable for the distribution of cosmetic, pharmaceutical or dermato-pharmaceutical products.
  • Such products may for example be distributed in the form of a milk, a cream, a gel, a paste, etc.
  • the products of the type mentioned above are commonly stored in a container made in particular of thermoplastic material or glass.
  • the storage container is equipped with a dispensing head movable relative to the container so as to allow the delivery of a dose of product.
  • variable volume compartment is generally delimited by a follower piston sealingly mounted within the storage container. Actuation of the metering pump causes aspiration of the product contained in the container compartment and the product outlet. As the product is dispensed, the follower piston rises inside the container under the effect of the depression resulting from the decrease in the volume of product.
  • Such devices are advantageous in that the product to be dispensed is packaged and stored isolated from air. However, such devices do not make it possible to ensure perfect reproducibility of the doses of product dispensed taking into account the internal design of the metering pumps.
  • the present invention aims to remedy this disadvantage.
  • the present invention aims to provide a device for packaging and dispensing a product for precisely dispensing the same amount of product for each use.
  • the present invention also aims to provide a device with a simple design, economical and easy to use.
  • the object of the invention is a device for packaging and dispensing a product, in particular a pharmaceutical or cosmetic product, comprising a storage container provided with at least one variable volume compartment containing said product, a means for pressurizing device capable of permanently pressurizing the product contained in said compartment, and a dispensing head comprising a mounting base fixed to the container.
  • the dispensing head further comprises a dispensing member mounted inside the mounting base while being rotatable, and a piston movable in translation inside the dispensing member and able to delimit at a distance inside said first and second dosing chambers opposite.
  • the dispensing head also comprises at least a first orifice formed on the dispensing member and adapted to be in direct fluid communication with the first metering chamber.
  • the dispensing head further comprises at least a second orifice formed on the dispensing member and adapted to be in direct fluid communication with the second metering chamber.
  • orifice capable of being in direct fluid communication with the metering chamber it is meant that said orifice is not associated with a pump or valve type selective dispensing means making it possible to force the passage of the product through said orifice.
  • the dispensing member is movable at least between a first position in which said first orifice is in communication fluidic with the variable volume compartment of the container and wherein said second port is in fluid communication with at least one outlet of the dispensing head, and a second position in which said second port is in fluid communication with said dispensing compartment. and wherein said first port is in fluid communication with said outlet port.
  • this metering chamber The filling of this metering chamber with product causes the displacement of the piston and consequently a decrease in the volume of the other metering chamber.
  • the product contained in this other metering chamber is thus distributed through the outlet orifice (s) of the dispensing head.
  • the piston under the effect of the pressure exerted by the product initially contained in the variable volume compartment of the container, the piston is able to move from a first position in which the volume of the chamber of The dosage in communication with this compartment is minimal and the volume of the other metering chamber is at a maximum, at a second position in which the volume of said metering chamber is at a maximum and the volume of said other metering chamber is minimal.
  • This displacement of the piston causes the product distribution.
  • the volume of one of the metering chambers increases, the volume of the other metering chamber decreases. The maximum volumes of the rooms are equal.
  • the dispensing head thus makes it possible to achieve precise product dosing and reproducible with each use.
  • the piston comprises means for adjusting before use the maximum volume of each of the first and second dosing chambers.
  • the piston comprises means for adjusting before use the maximum volume of each of the first and second dosing chambers.
  • the piston may for example comprise a rod on which is fixed adjustably at each end a piston head.
  • the piston heads can thus be moved closer to or further apart than the other according to the desired voids of the first and second metering chambers.
  • each end of the rod may comprise threads engaged with a thread of the associated piston head.
  • the piston may for example be in the form of a cylindrical disc. In this case, the maximum volume of each dosing chamber remains fixed.
  • the dispensing member may be rotatable about a geometric axis transverse to a longitudinal axis of the storage container. Said outlet orifice is advantageously provided on the mounting base.
  • said outlet orifice has a cross section of oblong shape and whose smaller dimension is smaller than the largest dimension of the section of the piston.
  • the dispensing member comprises an actuating means accessible from outside the mounting base.
  • the dispensing member may comprise means for locating the position of the first and second orifices and / or being shaped to identify these positions.
  • the mounting base is in the form of two hinged hulls which cover and hold the dispensing member in position.
  • the pressurizing means is disposed within an additional variable volume compartment of the storage container. No means located outside the storage container is used to perform this function.
  • the storage container advantageously comprises a partition wall sealingly delimiting the variable volume compartment containing said product and the additional variable volume compartment.
  • the partition wall is in the form of a movable piston within the storage container.
  • the pressurizing means may comprise a resiliently deformable mechanical member and exerting a permanent thrust force on the piston in the direction of the dispensing head.
  • the mechanical member may for example be in the form of a coil spring, or may further comprise one or more stacked spring springs, for example Belleville type.
  • said additional variable volume compartment is at atmospheric pressure.
  • the pressurizing means may comprise a gas under pressure.
  • the partition wall is in the form of a bag with deformable or flexible walls.
  • the pressurizing means may comprise a pressurized gas introduced into the space which is located between this pocket and the container walls, and which forms the additional variable volume compartment.
  • the device according to the invention can be used for packaging and dispensing a cosmetic, pharmaceutical or dermatological product, in particular in the form of a cream, a gel, a milk or a paste.
  • a cosmetic, pharmaceutical or dermatological product in particular in the form of a cream, a gel, a milk or a paste.
  • FIG. 1 is a sectional view of a packaging and dispensing device according to an exemplary embodiment of the invention
  • FIGS. 2 to 4 are front, side and top views, on a reduced scale, of the device of FIG. 1,
  • FIG. 5 is a sectional view illustrating the mounting of a piston inside a dispensing member of the device of FIG. 1,
  • Figures 12 to 13 are sectional views of the device of Figure 1 illustrating the possible adjustment of the product dosage.
  • Figure 1 a device for packaging and dispensing a product, designated by the general reference numeral 1 0, which comprises a container 12 for storing said product P and a dispensing head 14 of said product mounted on the container.
  • the device 10 is shown in a supposedly vertical position with the dispensing head 14 disposed above the container 12.
  • the dispensing head 14 is designed to provide a precise and reproducible dosage of the amount of product P delivered with each use.
  • the container 12 extends along an axis X-X 'longitudinal, here vertical.
  • the container 12 comprises a lower end forming a bottom 12a, an open opposite end forming an access opening 12b, and a peripheral wall 12c extending axially between these ends.
  • the peripheral wall 12c of the container may for example have a circular cross section or an oval section.
  • the container 12 also comprises an upper closure wall 16 and insert closure 12b open access opening said container.
  • the wall 16 may be secured to the container by any suitable means, for example by coiling, snapping, etc.
  • the wall 16 is provided with a through orifice 18.
  • the orifice 1 8 is here centered on the axis XX '.
  • the container 12 comprises a pusher piston which is mounted therein in a sealed manner by being freely movable in the axial direction.
  • the piston 20 is in frictional contact with the peripheral wall 12c of the container.
  • the piston 20 delimits inside the container 12 a variable volume compartment 22 which contains the product P.
  • the compartment 22 is delimited axially by the piston 20 and the wall 16 of the container. Port 18 forms an outlet for product P.
  • the piston 20 delimits inside the container 12 an additional compartment 24, also of variable volume.
  • the compartment 24 is at atmospheric pressure through the orifice 26 formed in the thickness of the bottom 12a of the container which forms an air inlet opening.
  • the compartment 26 is axially delimited by the bottom 12a of the container and by the piston 20.
  • the compartments 22, 24 are arranged axially on either side of the piston 20.
  • the container 12 and the piston 20 may each be made in one piece, for example by molding a thermoplastic material, for example polypropylene (PP) or polyethylene (PE).
  • a thermoplastic material for example polypropylene (PP) or polyethylene (PE).
  • the device 10 also comprises a spring 30 which is mounted inside the compartment 24 and which exerts a permanent thrust force on the piston 20 which tends to push it axially in the direction of the dispensing head 14.
  • the spring 30 thus makes it possible to pressurize permanently the product P contained inside the compartment 22 of the container.
  • the spring 30 is disposed axially between the piston 20 and the bottom 12a of the container.
  • the spring 30 is compressed axially between the piston 20 and the bottom 12a.
  • the spring 30 is centered on the axis XX '.
  • the spring 30 is here in the form of a helical compression spring.
  • the lower end turn of the spring 30 comes into bearing against the bottom 12a of the container while the upper end turn bears against the piston 20.
  • the spring 30 is in the form of a helical spring.
  • the dispensing head 14 comprises a mounting base 32 on the container 12 and a dispensing member 34 mounted inside thereof being rotatable about an axis YY '( Figure 3) transverse to the XX 'axis of the container.
  • the dispensing head 14 also comprises a piston 36 movable in translation inside the dispenser member 34.
  • the base 32 has a dual function, namely to ensure the mounting of the dispensing head 14 on the container 12 and maintain the axial position of the dispensing member 34 relative to said container.
  • the base 32 comprises two half-shells 38, 40 hinged, at an upper end, by a hinge (not shown) to allow the mounting of the dispenser member 34.
  • the hinge can example be of the type hinge film.
  • the half-shells 38, 40 and the hinge are advantageously made in one piece, by molding a synthetic material.
  • the lower ends of the half-shells 38, 40 are attached to the upper end of the container 12 by any suitable means, for example by snapping, gluing, snug fit, etc.
  • the half-shells 38, 40 have flat opposite faces.
  • the half-shells 38, 40 may have a spherical shape.
  • the base 32 comprises a through orifice 42 formed in its thickness.
  • the orifice 42 forms the outlet orifice of the dispensing head 14.
  • the orifice 42 is formed on the half-shells 38, 40.
  • the orifice 42 is coaxial with the axis X-X '.
  • the orifice 42 has an oblong shape. Alternatively, it is possible to provide an orifice 42 having another shape, for example circular or polygonal.
  • the dispensing member 34 is held axially between the base 32 and between the container 12, more precisely between the wall 16 thereof.
  • the base 32 covers the dispensing member 34.
  • the dispensing member 34 is in the form of a mobile wheel rotatable about the axis YY '.
  • the dispensing member 34 is made here in two half-rollers 44, 46 identical to each other.
  • Each half-wheel 44, 46 comprises a body 48, 50 bearing against the base 32, and a tube 52, 54 extending inwards from the body.
  • Each half-wheel 44, 46 also comprises a through orifice 56, 58 formed in the thickness of the body 48, 50 and opening inside the tube 52, 54.
  • the tubes 52, 54 are coaxial and the orifices 56, 58 are diametrically opposed.
  • the piston 36 of the dispensing head is mounted inside the tubes 52, 54 of the dispensing member 34.
  • the piston 36 is freely mounted inside the dispensing member 34 in a sealed manner.
  • the piston 36 is able to define inside the dispensing member 34 a first metering chamber 60 ( Figure 7) and a second metering chamber 62 opposite its position. inside said dispensing member.
  • the piston 36 comprises a rod 64 and a piston head 66, 68 attached to each end of said rod.
  • Each head 66, 68 is adjustably attached to the rod 64, for example by providing at each end thereof a thread engaging with a thread in a bore of the associated head 66, 68.
  • the piston heads 66, 68 are here identical to each other.
  • the cross section of each piston head 66, 68 corresponds precisely to the internal section of the tubes 52, 54 of the dispensing member 34.
  • the section of each piston head 66, 68 may be oval, square, etc.
  • the section of each head 66, 68 is greater than the smallest dimension of the outlet port 42.
  • the rod 64 and the heads 66, 68 may be made by molding a thermoplastic material.
  • Figure 5 is illustrated the mounting of the piston 36 within the two half-rollers 44, 46 of the dispenser member.
  • the first metering chamber 60 is delimited by the head 66 of the piston and by the tube 52 of the dispenser member.
  • the orifice 56 opens into the metering chamber 60.
  • the orifice 56 is in direct fluid communication with this chamber.
  • the second metering chamber 62 is delimited by the head 68 of the piston and the tube 54 of the dispenser member.
  • the orifice 58 opens into the metering chamber 62.
  • the orifice 58 is in direct fluid communication with this metering chamber 62.
  • the latter comprises a handle 70 (FIG. 2) which extends laterally outward through an orifice 72 formed in the The thickness of the base 32.
  • the handle 70 is in the form of an elongate disk portion.
  • the height of the handle 70 is such that its highest point is substantially flush with one of the flat faces of the base 32.
  • other configurations of the handle 70 are possible.
  • the handle 70 ( Figure 2) of the dispenser member 34 is oriented so that in a vertical position the orifices 56, 58 respectively face the orifices 18, 42.
  • marks or marks can also be provided on the handle 70 so as to locate the position of the orifices 56, 58.
  • part of the product P present in the compartment 22 of the container is forced through the orifice 18 of the container and the orifice 56 of the dispenser member. This causes a push of the product on the piston head 66 and the sliding of the piston 36 until the opposite head 68 abuts against the body 50 of the dispenser member as shown in FIG. 7.
  • the user can rotate the dispenser member 34 as shown in Figure 8 so as to finally bring the orifice 56 of said member opposite the outlet port 42 of the dispensing head as shown in Figure 9.
  • the orifice 58 of the dispensing member is in turn facing the orifice 18 of the container.
  • the orifice 58 is in direct fluid communication with the compartment 22 of the container via the orifice 18.
  • the piston 20 can then move axially towards the head 14 and a portion of the product P present in the compartment 22 of the container is forced through the orifice 18 of the container and the orifice 58 of the dispenser member. This causes the piston 36 to move inside the dispensing member 34 in the direction of the outlet orifice 42 of the dispensing head as shown in FIG.
  • the metering chamber 62 is created again and fills P product from the compartment 22 of the container. Simultaneously, the volume of the opposite metering chamber 60 decreases and the product already present in this chamber is distributed through the outlet orifice 42. The volume increase of the metering chamber 62 and its filling, as well as the distribution simultaneous product through the outlet port 42 continue until the head 66 of the piston abuts against the body 48 of the dispenser member as shown in Figure 11. The distribution of the product is continues during the emptying of the metering chamber 60.
  • the placing in communication of the compartment 22 of variable volume of the container with one of the orifices 56, 58 of the dispensing member causes the displacement of the piston 36, which makes it possible simultaneously to obtain a entrance to product P of the compartment 22 in the metering chamber 60, 62 in communication with this orifice, and a distribution of the product already in the other metering chamber through the outlet orifice 42 of the dispensing head.
  • each piston head 66, 68 is adjustably attached to the rod 64, which allows them to be brought closer to one another or away from one another in accordance with the desired values of the first and second dosing chambers 60, 62 when dispensing the product.
  • the piston heads 66, 68 can be unscrewed, while remaining in engagement with the rod 64, so as to reduce the volume of the metering chamber 62 as illustrated. in figure 13.
  • the adjustment of the dosing volume of the chambers 60, 62 can be made during assembly of the device according to the product to be stored and dispensed. It is also possible to allow the user to perform this adjustment of the volume of the chambers 60, 62 for example by means of a key provided with the device and intended to be inserted inside the chamber. a housing of complementary shape formed on each end face of the heads 66, 68 of the piston to ensure the screwing or unscrewing of these heads. This key is dimensioned so that it can be introduced through the orifices 42 and 56 or 58 so as to make this adjustment of the volume of metering of the chambers 60, 62 from the outside of the device 10.

Landscapes

  • Physics & Mathematics (AREA)
  • Fluid Mechanics (AREA)
  • General Physics & Mathematics (AREA)
  • Engineering & Computer Science (AREA)
  • Mechanical Engineering (AREA)
  • Containers And Packaging Bodies Having A Special Means To Remove Contents (AREA)

Abstract

The device for packaging and dispensing a product comprises a storage container (12) provided with at least one variable-volume compartment (22) containing the said product, a pressurizing means (30) able to permanently pressurize the product contained in the said compartment, and a dispensing head (14) comprising a mounting base (32) attached to the container. The dispensing head further comprises a dispensing member (34) mounted inside the mounting base (32) with the ability to move in rotation, a piston (36) with the ability to move in translation inside the dispensing member (34) and able to delimit, inside the said member, opposing first and second metering chambers (60, 62), and at least first and second orifices (56, 58) formed on the dispensing member (34) and respectively able to be in direct fluidic communication with the first and second metering chambers (60, 62).

Description

Dispositif pour le conditionnement et la distribution d' un produit, notamment d' un produit pharmaceutique ou cosmétique La présente invention concerne un dispositif de conditionnement et de distribution d'un produit.  The present invention relates to a device for packaging and dispensing a product.
Le dispositif est particulièrement adapté à la distribution de produits cosmétiques, pharmaceutiques ou dermato-pharmaceutiques. De tels produits peuvent par exemple être distribués sous forme d'un lait, d'une crème, d'un gel, d'une pâte, etc.  The device is particularly suitable for the distribution of cosmetic, pharmaceutical or dermato-pharmaceutical products. Such products may for example be distributed in the form of a milk, a cream, a gel, a paste, etc.
Les produits du type de ceux précités sont couramment stockés dans un récipient réalisé notamment en matériau thermoplastique ou en verre. Le récipient de stockage est équipé d'une tête de distribution mobile par rapport au récipient de manière à permettre la délivrance d'une dose de produit.  The products of the type mentioned above are commonly stored in a container made in particular of thermoplastic material or glass. The storage container is equipped with a dispensing head movable relative to the container so as to allow the delivery of a dose of product.
Dans le domaine de la pharmaceutique ou de la cosmétique, il est largement utilisé des récipients de stockage du type utilisant un compartiment à vo lume variable et équipé d'une pompe doseuse sans reprise d' air, généralement appelée « pompe airless », supportant la tête de distribution du produit.  In the field of pharmaceuticals or cosmetics, storage containers of the type using a variable volume compartment and equipped with a metering pump without air intake, generally called "airless pump", are widely used. dispensing head of the product.
Le compartiment à vo lume variable est généralement délimité par un piston suiveur monté de manière étanche à l' intérieur du récipient de stockage. Un actionnement de la pompe doseuse provoque une aspiration du produit contenu dans le compartiment du récipient et la sortie du produit. Au fur et à mesure de la distribution du produit, le piston suiveur remonte à l ' intérieur du récipient sous l ' effet de la dépression résultant de la diminution du vo lume de produit.  The variable volume compartment is generally delimited by a follower piston sealingly mounted within the storage container. Actuation of the metering pump causes aspiration of the product contained in the container compartment and the product outlet. As the product is dispensed, the follower piston rises inside the container under the effect of the depression resulting from the decrease in the volume of product.
De tels dispositifs sont avantageux dans la mesure où le produit à distribuer est conditionné et stocké en étant iso lé de l ' air. Cependant, de tels dispositifs ne permettent pas d' assurer une reproductibilité parfaite des doses de produit distribuées compte tenu de la conception interne des pompes doseuses . La présente invention vise à remédier à cet inconvénient. Such devices are advantageous in that the product to be dispensed is packaged and stored isolated from air. However, such devices do not make it possible to ensure perfect reproducibility of the doses of product dispensed taking into account the internal design of the metering pumps. The present invention aims to remedy this disadvantage.
Plus particulièrement, la présente invention vise à prévoir un dispositif de conditionnement et de distribution d'un produit permettant de distribuer précisément la même quantité de produit à chaque utilisation.  More particularly, the present invention aims to provide a device for packaging and dispensing a product for precisely dispensing the same amount of product for each use.
La présente invention vise également à prévoir un dispositif présentant une conception simple, économique et facile d'utilisation.  The present invention also aims to provide a device with a simple design, economical and easy to use.
L 'invention a pour obj et un dispositif de conditionnement et de distribution d 'un produit, notamment d 'un produit pharmaceutique ou cosmétique, comprenant un récipient de stockage pourvu d ' au moins un compartiment à vo lume variable contenant ledit produit, un moyen de pressurisation apte à pressuriser de façon permanente le produit contenu dans ledit compartiment, et une tête de distribution comprenant une embase de montage fixée sur le récipient.  The object of the invention is a device for packaging and dispensing a product, in particular a pharmaceutical or cosmetic product, comprising a storage container provided with at least one variable volume compartment containing said product, a means for pressurizing device capable of permanently pressurizing the product contained in said compartment, and a dispensing head comprising a mounting base fixed to the container.
La tête de distribution comprend en outre un organe de distribution monté à l ' intérieur de l ' embase de montage en étant mobile à rotation, et un piston mobile en translation à l' intérieur de l ' organe de distribution et apte à délimiter à l' intérieur dudit organe des première et deuxième chambres de dosage opposées.  The dispensing head further comprises a dispensing member mounted inside the mounting base while being rotatable, and a piston movable in translation inside the dispensing member and able to delimit at a distance inside said first and second dosing chambers opposite.
La tête de distribution comprend également au moins un premier orifice ménagé sur l 'organe de distribution et apte à être en communication fluidique directe avec la première chambre de dosage. La tête de distribution comprend encore au moins un deuxième orifice ménagé sur l 'organe de distribution et apte à être en communication fluidique directe avec la deuxième chambre de dosage.  The dispensing head also comprises at least a first orifice formed on the dispensing member and adapted to be in direct fluid communication with the first metering chamber. The dispensing head further comprises at least a second orifice formed on the dispensing member and adapted to be in direct fluid communication with the second metering chamber.
Par « orifice apte à être en communication fluidique directe avec la chambre de dosage», on entend que ledit orifice n' est pas associé à un moyen de distribution sélective du type pompe ou valve permettant de forcer le passage du produit à travers ledit orifice.  By "orifice capable of being in direct fluid communication with the metering chamber", it is meant that said orifice is not associated with a pump or valve type selective dispensing means making it possible to force the passage of the product through said orifice.
Selon une caractéristique générale de la tête de distribution, l ' organe de distribution est mobile au moins entre une première position dans laquelle ledit premier orifice est en communication fluidique avec le compartiment à vo lume variable du récipient et dans laquelle ledit deuxième orifice est en communication fluidique avec au moins un orifice de sortie de la tête de distribution, et une deuxième position dans laquelle ledit deuxième orifice est en communication fluidique avec ledit compartiment à vo lume variable et dans laquelle ledit premier orifice est en communication fluidique avec ledit orifice de sortie. According to a general characteristic of the dispensing head, the dispensing member is movable at least between a first position in which said first orifice is in communication fluidic with the variable volume compartment of the container and wherein said second port is in fluid communication with at least one outlet of the dispensing head, and a second position in which said second port is in fluid communication with said dispensing compartment. and wherein said first port is in fluid communication with said outlet port.
Avec un tel dispositif, lorsque l 'un des orifices de l ' organe de distribution est en communication fluidique avec le compartiment à vo lume variable du récipient de stockage, sous l ' effet de la pression exercée par le moyen de pressurisation, le produit contenu dans ce compartiment est forcé à travers ledit orifice et poussé à l ' intérieur de la chambre de dosage associée qui est en communication fluidique avec cet orifice.  With such a device, when one of the orifices of the dispensing member is in fluid communication with the variable volume compartment of the storage container, under the effect of the pressure exerted by the pressurizing means, the product contained in this compartment is forced through said orifice and pushed into the associated metering chamber which is in fluid communication with that orifice.
Le remplissage de cette chambre de dosage en produit provoque le déplacement du piston et par conséquence une diminution du vo lume de l ' autre chambre de dosage. Le produit contenu dans cette autre chambre de dosage est ainsi distribué au travers du ou des orifices de sortie de la tête de distribution.  The filling of this metering chamber with product causes the displacement of the piston and consequently a decrease in the volume of the other metering chamber. The product contained in this other metering chamber is thus distributed through the outlet orifice (s) of the dispensing head.
En d' autres termes, sous l ' effet de la pression exercée par le produit initialement contenu dans le compartiment à vo lume variable du récipient, le piston est apte à se déplacer d'une première position dans laquelle le vo lume de la chambre de dosage en communication avec ce compartiment est minimal et le volume de l ' autre chambre de dosage est maximal, à une deuxième position dans laquelle le vo lume de ladite chambre de dosage est maximal et le vo lume de ladite autre chambre de dosage est minimal. Ce déplacement du piston provoque la distribution de produit. Lorsque le vo lume de l 'une des chambres de dosage augmente, le vo lume de l ' autre chambre de dosage diminue. Les volumes maximaux des chambres sont égaux.  In other words, under the effect of the pressure exerted by the product initially contained in the variable volume compartment of the container, the piston is able to move from a first position in which the volume of the chamber of The dosage in communication with this compartment is minimal and the volume of the other metering chamber is at a maximum, at a second position in which the volume of said metering chamber is at a maximum and the volume of said other metering chamber is minimal. This displacement of the piston causes the product distribution. As the volume of one of the metering chambers increases, the volume of the other metering chamber decreases. The maximum volumes of the rooms are equal.
Lorsque l 'un des orifices de l ' organe de distribution est mis en communication avec le compartiment à vo lume variable du récipient, il se produit donc un remplissage de la chambre de dosage en communication fluidique avec cet orifice et une sortie du produit contenu dans l ' autre chambre de dosage. When one of the orifices of the dispensing member is placed in communication with the variable volume compartment of the container, a filling of the dosing chamber occurs. in fluid communication with this orifice and an outlet of the product contained in the other metering chamber.
La tête de distribution permet ainsi de réaliser un dosage précis de produit et reproductible à chaque utilisation.  The dispensing head thus makes it possible to achieve precise product dosing and reproducible with each use.
De préférence, le piston comprend des moyens pour régler avant utilisation le vo lume maximal de chacune des première et deuxième chambres de dosage. Ainsi, il est possible d' adapter la quantité de produit délivrée selon le dosage souhaité.  Preferably, the piston comprises means for adjusting before use the maximum volume of each of the first and second dosing chambers. Thus, it is possible to adapt the quantity of product delivered according to the desired dosage.
Dans ce but, le piston peut par exemple comprendre une tige sur laquelle est fixée de manière réglable à chaque extrémité une tête de piston. Les têtes de piston peuvent ainsi être rapprochées ou éloignées l 'une par rapport à l ' autre selon les vo lumes souhaités des première et deuxième chambres de dosage .  For this purpose, the piston may for example comprise a rod on which is fixed adjustably at each end a piston head. The piston heads can thus be moved closer to or further apart than the other according to the desired voids of the first and second metering chambers.
Par exemple, chaque extrémité de la tige peut comprendre un filetage en prise avec un filetage de la tête de piston associée. En variante, il reste cependant possible de prévoir d' autres conceptions du piston. Le piston peut par exemple se présenter sous la forme d 'un disque cylindrique. Dans ce cas, le volume maximal de chaque chambre de dosage reste fixe.  For example, each end of the rod may comprise threads engaged with a thread of the associated piston head. Alternatively, it remains possible to provide other designs of the piston. The piston may for example be in the form of a cylindrical disc. In this case, the maximum volume of each dosing chamber remains fixed.
L ' organe de distribution peut être mobile à rotation autour d'un axe géométrique transversal à un axe longitudinal du récipient de stockage. Ledit orifice de sortie est avantageusement ménagé sur l ' embase de montage.  The dispensing member may be rotatable about a geometric axis transverse to a longitudinal axis of the storage container. Said outlet orifice is advantageously provided on the mounting base.
Avantageusement, ledit orifice de sortie présente une section transversale de forme oblongue et dont la plus petite dimension est inférieure à la plus grande dimension de la section du piston. Ainsi, on assure de façon simp le et économique la retenue du piston à l' intérieur de l ' organe de distribution.  Advantageously, said outlet orifice has a cross section of oblong shape and whose smaller dimension is smaller than the largest dimension of the section of the piston. Thus, it is simply and economically ensured the retention of the piston inside the dispenser member.
Avantageusement, l ' organe de distribution comprend un moyen d' actionnement accessible depuis l' extérieur de l ' embase de montage. L ' organe de distribution peut comprendre des moyens pour repérer la position des premier et deuxième orifices et/ou être conformé pour repérer ces positions. Dans un mode de réalisation particulier, l ' embase de montage se présente sous la forme de deux coques articulées qui recouvrent et qui maintiennent en position l ' organe de distribution. Advantageously, the dispensing member comprises an actuating means accessible from outside the mounting base. The dispensing member may comprise means for locating the position of the first and second orifices and / or being shaped to identify these positions. In a particular embodiment, the mounting base is in the form of two hinged hulls which cover and hold the dispensing member in position.
De préférence, le moyen de pressurisation est disposé à l' intérieur d'un compartiment additionnel à vo lume variable du récipient de stockage. Aucun moyen situé en dehors du récipient de stockage n' est utilisé pour assurer cette fonction.  Preferably, the pressurizing means is disposed within an additional variable volume compartment of the storage container. No means located outside the storage container is used to perform this function.
Le récipient de stockage comprend avantageusement une cloison de séparation délimitant de manière étanche le compartiment à vo lume variable contenant ledit produit et le compartiment à vo lume variable additionnel.  The storage container advantageously comprises a partition wall sealingly delimiting the variable volume compartment containing said product and the additional variable volume compartment.
Dans un mo de de réalisation particulier, la cloison de séparation est réalisée sous la forme d'un piston mobile à l' intérieur du récipient de stockage. Le moyen de pressurisation peut comprendre un organe mécanique déformable élastiquement et exerçant un effort de poussée permanent sur le piston en direction de la tête de distribution. L 'organe mécanique peut par exemp le se présenter sous la forme d'un ressort hélicoïdal, ou peut encore comprendre une ou plusieurs rondelles ressorts élastiques empilées, par exemple du type Belleville. Dans ce mode de réalisation particulier, ledit compartiment à vo lume variable additionnel est à la pression atmosphérique. En variante, le moyen de pressurisation peut comprendre un gaz sous pression.  In a particular embodiment, the partition wall is in the form of a movable piston within the storage container. The pressurizing means may comprise a resiliently deformable mechanical member and exerting a permanent thrust force on the piston in the direction of the dispensing head. The mechanical member may for example be in the form of a coil spring, or may further comprise one or more stacked spring springs, for example Belleville type. In this particular embodiment, said additional variable volume compartment is at atmospheric pressure. Alternatively, the pressurizing means may comprise a gas under pressure.
Dans un autre mode de réalisation, la cloison de séparation est réalisée sous la forme d 'une poche à parois déformables ou souples. Dans ce cas, le moyen de pressurisation peut comprendre un gaz sous pression introduit dans l ' espace qui est situé entre cette poche et les parois du récipient, et qui forme le compartiment à vo lume variable additionnel.  In another embodiment, the partition wall is in the form of a bag with deformable or flexible walls. In this case, the pressurizing means may comprise a pressurized gas introduced into the space which is located between this pocket and the container walls, and which forms the additional variable volume compartment.
Avantageusement, le dispositif selon l'invention peut être utilisé pour le conditionnement et la distribution d'un produit cosmétique, pharmaceutique ou dermatologique, notamment sous forme d'une crème, d'un gel, d'un lait ou d 'une pâte. La présente invention sera mieux comprise à l ' étude de la description détaillée d'un mode de réalisation, pris à titre d' exemple nullement limitatif et illustré par les dessins annexés, sur lesquels : Advantageously, the device according to the invention can be used for packaging and dispensing a cosmetic, pharmaceutical or dermatological product, in particular in the form of a cream, a gel, a milk or a paste. The present invention will be better understood from the study of the detailed description of an embodiment, taken by way of nonlimiting example and illustrated by the appended drawings, in which:
- la figure 1 est une vue en coupe d'un dispositif de conditionnement et de distribution selon un exemple de réalisation de l' invention,  FIG. 1 is a sectional view of a packaging and dispensing device according to an exemplary embodiment of the invention,
- les figures 2 à 4 sont des vues de face, de côté et de dessus, à échelle réduite, du dispositif de la figure 1 ,  FIGS. 2 to 4 are front, side and top views, on a reduced scale, of the device of FIG. 1,
- la figure 5 est une vue en coupe illustrant le montage d'un piston à l' intérieur d'un organe de distribution du dispositif de la figure 1 ,  FIG. 5 is a sectional view illustrating the mounting of a piston inside a dispensing member of the device of FIG. 1,
- les figures 6 à 1 1 sont des vues en coupe du dispositif de la figure 1 selon différentes positions d 'utilisation, et  - Figures 6 to 1 1 are sectional views of the device of Figure 1 in different positions of use, and
- les figures 12 à 1 3 sont des vues en coupe du dispositif de la figure 1 illustrant l ' ajustement possible du dosage de produit.  Figures 12 to 13 are sectional views of the device of Figure 1 illustrating the possible adjustment of the product dosage.
Sur la figure 1 est illustré un dispositif de conditionnement et de distribution d'un produit, désigné par la référence numérique générale 1 0, qui comprend un récipient 12 de stockage dudit produit P et une tête 14 de distribution dudit produit montée sur le récipient. Le dispositif 10 est représenté dans une position supposée verticale avec la tête 14 de distribution disposée au-dessus du récipient 12.  In Figure 1 is illustrated a device for packaging and dispensing a product, designated by the general reference numeral 1 0, which comprises a container 12 for storing said product P and a dispensing head 14 of said product mounted on the container. The device 10 is shown in a supposedly vertical position with the dispensing head 14 disposed above the container 12.
Comme cela sera décrit plus en détail par la suite, la tête 14 de distribution est conçue de sorte à assurer un dosage précis et reproductible de la quantité de produit P délivrée à chaque utilisation.  As will be described in more detail below, the dispensing head 14 is designed to provide a precise and reproducible dosage of the amount of product P delivered with each use.
Le récipient 12 s ' étend selon un axe X-X' longitudinal, ici vertical. Le récipient 12 comprend une extrémité inférieure formant un fond 12a, une extrémité opposée ouverte formant une ouverture d' accès 12b, et une paroi périphérique 12c s ' étendant axialement entre ces extrémités . La paroi périphérique 12c du récipient peut par exemple présenter une section transversale circulaire ou une section ovale.  The container 12 extends along an axis X-X 'longitudinal, here vertical. The container 12 comprises a lower end forming a bottom 12a, an open opposite end forming an access opening 12b, and a peripheral wall 12c extending axially between these ends. The peripheral wall 12c of the container may for example have a circular cross section or an oval section.
Le récipient 12 comprend également une paroi 16 d ' obturation 16 supérieure rapportée et obturant l ' ouverture d' accès 12b ouverte dudit récipient. La paroi 16 peut être fixée sur le récipient par tout moyen approprié, par exemple par co llage, encliquetage, etc. La paroi 16 est pourvue d'un orifice 1 8 traversant. L 'orifice 1 8 est ici centré sur l ' axe X-X' . The container 12 also comprises an upper closure wall 16 and insert closure 12b open access opening said container. The wall 16 may be secured to the container by any suitable means, for example by coiling, snapping, etc. The wall 16 is provided with a through orifice 18. The orifice 1 8 is here centered on the axis XX '.
Le récipient 12 comprend un piston 20 pousseur qui est monté à l'intérieur de celui-ci de manière étanche en étant mobile librement dans le sens axial. Le piston 20 est en contact de friction avec la paroi périphérique 12c du récipient. Le piston 20 délimite à l' intérieur du récipient 12 un compartiment 22 à vo lume variable qui contient le produit P . Le compartiment 22 est délimité axialement par le piston 20 et par la paroi 16 du récipient. L 'orifice 1 8 forme un orifice de sortie pour le produit P .  The container 12 comprises a pusher piston which is mounted therein in a sealed manner by being freely movable in the axial direction. The piston 20 is in frictional contact with the peripheral wall 12c of the container. The piston 20 delimits inside the container 12 a variable volume compartment 22 which contains the product P. The compartment 22 is delimited axially by the piston 20 and the wall 16 of the container. Port 18 forms an outlet for product P.
Axialement du côté opposé au compartiment 22, le piston 20 délimite à l ' intérieur du récipient 12 un compartiment 24 additionnel, également à vo lume variable. Le compartiment 24 est à la pression atmosphérique par l ' intermédiaire de l ' orifice 26 ménagé dans l ' épaisseur du fond 12a du récipient qui forme un orifice d' entrée d' air. Le compartiment 26 est axialement délimité par le fond 12a du récipient et par le piston 20. Les compartiments 22, 24 sont disposés axialement de part et d' autre du piston 20.  Axially on the opposite side to the compartment 22, the piston 20 delimits inside the container 12 an additional compartment 24, also of variable volume. The compartment 24 is at atmospheric pressure through the orifice 26 formed in the thickness of the bottom 12a of the container which forms an air inlet opening. The compartment 26 is axially delimited by the bottom 12a of the container and by the piston 20. The compartments 22, 24 are arranged axially on either side of the piston 20.
Le récipient 12 et le piston 20 peuvent être réalisés chacun en une pièce, par exemp le par moulage d'une matière thermoplastique, par exemple en polypropylène (PP) ou en polyéthylène (PE) .  The container 12 and the piston 20 may each be made in one piece, for example by molding a thermoplastic material, for example polypropylene (PP) or polyethylene (PE).
Le dispositif 10 comprend également un ressort 30 qui est monté à l' intérieur du compartiment 24 et qui exerce un effort de poussée permanent sur le piston 20 qui tend à le pousser axialement en direction de la tête 14 de distribution. Le ressort 30 permet ainsi de pressuriser de façon permanente le produit P contenu à l' intérieur du compartiment 22 du récipient.  The device 10 also comprises a spring 30 which is mounted inside the compartment 24 and which exerts a permanent thrust force on the piston 20 which tends to push it axially in the direction of the dispensing head 14. The spring 30 thus makes it possible to pressurize permanently the product P contained inside the compartment 22 of the container.
Le ressort 30 est disposé axialement entre le piston 20 et le fond 12a du récipient. Le ressort 30 est comprimé axialement entre le piston 20 et le fond 12a. Le ressort 30 est centré sur l' axe X-X' . Le ressort 30 se présente ici sous la forme d'un ressort hélicoïdal de compression. La spire d' extrémité inférieure du ressort 30 vient en appui contre le fond 12a du récipient tandis que la spire d'extrémité supérieure vient en appui contre le piston 20. Dans l'exemple de réalisation illustré, le ressort 30 se présente sous la forme d'un ressort hélicoïdal. En variante, pour exercer un effort axial sur le piston 20, il est possible de prévoir une rondelle élastique ou plusieurs rondelles élastiques empilées axialement, par exemple du type Belleville. The spring 30 is disposed axially between the piston 20 and the bottom 12a of the container. The spring 30 is compressed axially between the piston 20 and the bottom 12a. The spring 30 is centered on the axis XX '. The spring 30 is here in the form of a helical compression spring. The lower end turn of the spring 30 comes into bearing against the bottom 12a of the container while the upper end turn bears against the piston 20. In the illustrated embodiment, the spring 30 is in the form of a helical spring. Alternatively, to exert an axial force on the piston 20, it is possible to provide an elastic washer or several elastic washers stacked axially, for example of the Belleville type.
La tête 14 de distribution comprend une embase 32 de montage sur le récipient 12 et un organe de distribution 34 monté à l'intérieur de celle-ci en étant mobile à rotation autour d'un axe Y-Y' (figure 3) transversal à l'axe X-X' du récipient. La tête 14 de distribution comprend également un piston 36 mobile en translation à l'intérieur de l'organe de distribution 34.  The dispensing head 14 comprises a mounting base 32 on the container 12 and a dispensing member 34 mounted inside thereof being rotatable about an axis YY '(Figure 3) transverse to the XX 'axis of the container. The dispensing head 14 also comprises a piston 36 movable in translation inside the dispenser member 34.
L'embase 32 assure une double fonction, à savoir assurer le montage de la tête 14 de distribution sur le récipient 12 et maintenir la position axiale de l'organe de distribution 34 par rapport audit récipient.  The base 32 has a dual function, namely to ensure the mounting of the dispensing head 14 on the container 12 and maintain the axial position of the dispensing member 34 relative to said container.
Dans l'exemple de réalisation illustré, l'embase 32 comprend deux demi-coques 38, 40 articulées, à une extrémité supérieure, par une charnière (non représentée) pour permettre le montage de l'organe de distribution 34. La charnière peut par exemple être du type charnière film. Les demi-coques 38, 40 et la charnière sont avantageusement réalisées en une seule pièce, par moulage d'une matière synthétique. Les extrémités inférieures des demi-coques 38, 40 sont fixées sur l'extrémité supérieure du récipient 12 par tout moyen approprié, par exemple par encliquetage, collage, ajustement serré, etc. Dans l'exemple de réalisation illustré, les demi-coques 38, 40 présentent des faces opposées plates. En variante, les demi-coques 38, 40 peuvent présenter une forme sphérique.  In the embodiment illustrated, the base 32 comprises two half-shells 38, 40 hinged, at an upper end, by a hinge (not shown) to allow the mounting of the dispenser member 34. The hinge can example be of the type hinge film. The half-shells 38, 40 and the hinge are advantageously made in one piece, by molding a synthetic material. The lower ends of the half-shells 38, 40 are attached to the upper end of the container 12 by any suitable means, for example by snapping, gluing, snug fit, etc. In the exemplary embodiment illustrated, the half-shells 38, 40 have flat opposite faces. Alternatively, the half-shells 38, 40 may have a spherical shape.
L'embase 32 comprend un orifice 42 de sortie traversant ménagé dans son épaisseur. L'orifice 42 forme l'orifice de sortie de la tête 14 de distribution. L'orifice 42 est formé sur les demi-coques 38, 40. Dans l'exemple de réalisation illustré, l'orifice 42 est coaxial à l'axe X-X'. Dans l'exemple de réalisation illustré, l'orifice 42 présente une forme oblongue. En variante, il est possible de prévoir un orifice 42 présentant une autre forme, par exemple circulaire ou polygonale. The base 32 comprises a through orifice 42 formed in its thickness. The orifice 42 forms the outlet orifice of the dispensing head 14. The orifice 42 is formed on the half-shells 38, 40. In the exemplary embodiment illustrated, the orifice 42 is coaxial with the axis X-X '. In the exemplary embodiment illustrated, the orifice 42 has an oblong shape. Alternatively, it is possible to provide an orifice 42 having another shape, for example circular or polygonal.
L 'organe de distribution 34 est maintenu axialement entre l ' embase 32 et entre le récipient 12, plus précisément entre la paroi 16 de celui-ci. L ' embase 32 recouvre l ' organe de distribution 34. Dans l ' exemple de réalisation illustré, l 'organe de distribution 34 se présente sous la forme d'une roulette mobile à rotation autour de l ' axe Y-Y ' . L 'organe de distribution 34 est réalisé ici en deux demi- roulettes 44, 46 identiques entre elles. Chaque demi-roulette 44, 46 comprend un corps 48 , 50 venant en appui contre l' embase 32, et un tube 52, 54 s ' étendant vers l' intérieur à partir du corps. Chaque demi-roulette 44 , 46 comprend également un orifice 56 , 58 traversant ménagé dans l ' épaisseur du corps 48 , 50 et débouchant à l' intérieur du tube 52, 54. Les tubes 52, 54 sont coaxiaux et les orifices 56, 58 sont diamétralement opposés .  The dispensing member 34 is held axially between the base 32 and between the container 12, more precisely between the wall 16 thereof. The base 32 covers the dispensing member 34. In the exemplary embodiment illustrated, the dispensing member 34 is in the form of a mobile wheel rotatable about the axis YY '. The dispensing member 34 is made here in two half-rollers 44, 46 identical to each other. Each half-wheel 44, 46 comprises a body 48, 50 bearing against the base 32, and a tube 52, 54 extending inwards from the body. Each half-wheel 44, 46 also comprises a through orifice 56, 58 formed in the thickness of the body 48, 50 and opening inside the tube 52, 54. The tubes 52, 54 are coaxial and the orifices 56, 58 are diametrically opposed.
Le piston 36 de la tête de distribution est monté à l' intérieur des tubes 52, 54 de l 'organe de distribution 34. Le piston 36 est monté libre à l' intérieur de l 'organe de distribution 34 de manière étanche. Comme cela sera décrit plus en détail par la suite, le piston 36 est apte à délimiter à l 'intérieur de l ' organe de distribution 34 une première chambre de dosage 60 (figure 7) et une deuxième chambre de dosage 62 opposée selon sa position à l ' intérieur dudit organe de distribution.  The piston 36 of the dispensing head is mounted inside the tubes 52, 54 of the dispensing member 34. The piston 36 is freely mounted inside the dispensing member 34 in a sealed manner. As will be described in more detail later, the piston 36 is able to define inside the dispensing member 34 a first metering chamber 60 (Figure 7) and a second metering chamber 62 opposite its position. inside said dispensing member.
Dans l' exemple de réalisation illustré, le piston 36 comprend une tige 64 et une tête 66, 68 de piston fixée à chaque extrémité de ladite tige. Chaque tête 66, 68 est fixée de manière réglable sur la tige 64, par exemple en prévoyant à chaque extrémité de celle-ci un filetage en prise avec un filetage ménagé dans un alésage de la tête 66, 68 associée. Les têtes 66, 68 de piston sont ici identiques entre elles. La section transversale de chaque tête 66, 68 de piston correspond précisément à la section interne des tubes 52, 54 de l ' organe de distribution 34. La section de chaque tête 66, 68 de piston peut être de forme ovale, carrée, etc. La section de chaque tête 66, 68 est supérieure à la plus petite dimension de l ' orifice de sortie 42. La tige 64 et les têtes 66, 68 peuvent être réalisées par moulage d'une matière thermoplastique. A la figure 5 est illustré le montage du piston 36 à l'intérieur des deux-demi-roulettes 44, 46 de l'organe de distribution. In the exemplary embodiment illustrated, the piston 36 comprises a rod 64 and a piston head 66, 68 attached to each end of said rod. Each head 66, 68 is adjustably attached to the rod 64, for example by providing at each end thereof a thread engaging with a thread in a bore of the associated head 66, 68. The piston heads 66, 68 are here identical to each other. The cross section of each piston head 66, 68 corresponds precisely to the internal section of the tubes 52, 54 of the dispensing member 34. The section of each piston head 66, 68 may be oval, square, etc. The section of each head 66, 68 is greater than the smallest dimension of the outlet port 42. The rod 64 and the heads 66, 68 may be made by molding a thermoplastic material. In Figure 5 is illustrated the mounting of the piston 36 within the two half-rollers 44, 46 of the dispenser member.
Comme cela est visible à la figure 7, la première chambre de dosage 60 est délimitée par la tête 66 du piston et par le tube 52 de l ' organe de distribution. L 'orifice 56 débouche dans la chambre de dosage 60. L ' orifice 56 est en communication fluidique directe avec cette chambre.  As can be seen in FIG. 7, the first metering chamber 60 is delimited by the head 66 of the piston and by the tube 52 of the dispenser member. The orifice 56 opens into the metering chamber 60. The orifice 56 is in direct fluid communication with this chamber.
En se référant de nouveau à la figure 1 , la deuxième chambre de dosage 62 est délimitée par la tête 68 du piston et par le tube 54 de l ' organe de distribution. L ' orifice 58 débouche dans la chambre de dosage 62. L 'orifice 58 est en communication fluidique directe avec cette chambre de dosage 62.  Referring again to Figure 1, the second metering chamber 62 is delimited by the head 68 of the piston and the tube 54 of the dispenser member. The orifice 58 opens into the metering chamber 62. The orifice 58 is in direct fluid communication with this metering chamber 62.
De sorte que l'utilisateur puisse commander la rotation de l ' organe de distribution 34 depuis l ' extérieur, celui-ci comporte une poignée 70 (figure 2) qui s ' étend latéralement vers l ' extérieur à travers un orifice 72 ménagé dans l ' épaisseur de l' embase 32. La poignée 70 se présente sous la forme d'une portion de disque de forme allongée. La hauteur de la poignée 70 est telle que son point le plus haut affleure sensiblement avec l 'une des faces plates de l ' embase 32. En variante, d' autres configurations de la poignée 70 sont possibles .  So that the user can control the rotation of the dispensing member 34 from the outside, the latter comprises a handle 70 (FIG. 2) which extends laterally outward through an orifice 72 formed in the The thickness of the base 32. The handle 70 is in the form of an elongate disk portion. The height of the handle 70 is such that its highest point is substantially flush with one of the flat faces of the base 32. Alternatively, other configurations of the handle 70 are possible.
Pour procéder à la distribution du produit P contenu dans le compartiment 22 du récipient, l'utilisateur procède de la manière suivante.  To distribute the product P contained in the compartment 22 of the container, the user proceeds as follows.
À partir de la position illustrée à la figure 1 qui correspond à une position de repos de la tête 14 de distribution, l 'utilisateur fait pivoter l 'organe de distribution 34 de sorte à amener l ' orifice 56 dudit organe en regard de l ' orifice 1 8 du récipient comme cela est illustré à la figure 5. L 'orifice 56 est en communication fluidique directe avec le compartiment 22 du récipient. Dans cette position, l'orifice 58 de l'organe de distribution est également en regard de l'orifice de sortie 42 de la tête de distribution. From the position illustrated in Figure 1 which corresponds to a rest position of the dispensing head 14, the user rotates the dispenser member 34 so as to bring the orifice 56 of said member opposite the port 1 8 of the container as shown in Figure 5. The orifice 56 is in direct fluid communication with the compartment 22 of the container. In this position, the orifice 58 of the dispensing member is also opposite the outlet orifice 42 of the dispensing head.
Avantageusement, la poignée 70 (figure 2) de l'organe de distribution 34 est orientée de sorte que dans une position verticale les orifices 56, 58 viennent respectivement en regard des orifices 18, 42. En variante ou en combinaison, des repères ou marques peuvent également être prévus sur la poignée 70 de sorte à repérer la position des orifices 56, 58.  Advantageously, the handle 70 (Figure 2) of the dispenser member 34 is oriented so that in a vertical position the orifices 56, 58 respectively face the orifices 18, 42. As a variant or in combination, marks or marks can also be provided on the handle 70 so as to locate the position of the orifices 56, 58.
Dans la position illustrée à la figure 6, l'orifice 18 de sortie du récipient n'est plus obturé par l'organe de distribution 34. Sous l'effet de l'effort de poussée permanent exercé par le ressort 30, le piston 20 peut alors se déplacer axialement en direction de la tête 14 de distribution comme cela est illustré à la figure 7. Pour des raisons de compréhension, le déplacement axial du piston 20 qui est illustré à la figure 7 a été exagéré à partir de sa position précédente représentée à la figure 6.  In the position illustrated in FIG. 6, the outlet orifice 18 of the container is no longer closed by the dispenser member 34. Under the effect of the permanent thrust force exerted by the spring 30, the piston 20 can then move axially in the direction of the dispensing head 14 as shown in Figure 7. For reasons of understanding, the axial displacement of the piston 20 which is illustrated in Figure 7 has been exaggerated from its previous position shown in Figure 6.
Avec le déplacement du piston 20, une partie du produit P présent dans le compartiment 22 du récipient est forcée à travers l'orifice 18 du récipient et l'orifice 56 de l'organe de distribution. Ceci provoque une poussée dudit produit sur la tête 66 de piston et le coulissement du piston 36 jusqu'à ce que la tête 68 opposée vienne buter contre le corps 50 de l'organe de distribution comme cela est illustré à la figure 7.  With the displacement of the piston 20, part of the product P present in the compartment 22 of the container is forced through the orifice 18 of the container and the orifice 56 of the dispenser member. This causes a push of the product on the piston head 66 and the sliding of the piston 36 until the opposite head 68 abuts against the body 50 of the dispenser member as shown in FIG. 7.
Le déplacement du piston 36 à l'intérieur de l'organe de distribution 34 sous l'effet de la poussée du produit P se traduit par la création de la chambre de dosage 60, puis l'augmentation du volume de cette chambre et son remplissage simultané en produit P jusqu'à ce que la tête 68 du piston vienne buter contre l'organe de distribution. Simultanément à l'augmentation du volume de la chambre de dosage 60, il se produit une diminution du volume de la chambre de dosage 62. Dans la position illustrée à la figure 7, la tête 68 de piston obture l'orifice 58 de l'organe de distribution. Le volume de la chambre de dosage 62 est nul et le volume de la chambre de dosage 60 est maximal. À partir de la position illustrée à la figure 7, l'utilisateur peut faire pivoter l'organe de distribution 34 comme cela est illustré à la figure 8 de sorte à amener finalement l'orifice 56 dudit organe en regard de l'orifice de sortie 42 de la tête de distribution comme représenté à la figure 9. Dans cette position, l'orifice 58 de l'organe de distribution est quant à lui en regard de l'orifice 18 du récipient. L'orifice 58 est en communication fluidique directe avec le compartiment 22 du récipient via l'orifice 18. Lors du déplacement de l'organe de distribution 34 de la position illustrée à la figure 7 vers la position illustrée à la figure 9, l'orifice 18 du récipient est obturé par ledit organe de distribution. The displacement of the piston 36 inside the dispensing member 34 under the effect of the thrust of the product P results in the creation of the metering chamber 60, then increasing the volume of this chamber and filling it simultaneous product P until the head 68 of the piston abuts against the dispensing member. Simultaneously with the increase of the volume of the metering chamber 60, there is a decrease in the volume of the metering chamber 62. In the position illustrated in FIG. 7, the piston head 68 closes the orifice 58 of the distribution organ. The volume of the metering chamber 62 is zero and the volume of the metering chamber 60 is maximum. From the position illustrated in Figure 7, the user can rotate the dispenser member 34 as shown in Figure 8 so as to finally bring the orifice 56 of said member opposite the outlet port 42 of the dispensing head as shown in Figure 9. In this position, the orifice 58 of the dispensing member is in turn facing the orifice 18 of the container. The orifice 58 is in direct fluid communication with the compartment 22 of the container via the orifice 18. During the displacement of the dispensing member 34 from the position illustrated in FIG. 7 to the position illustrated in FIG. 9, the orifice 18 of the container is closed by said dispensing member.
Dans la position illustrée à la figure 9, sous l'effet de l'effort exercé par le ressort 30, le piston 20 peut alors se déplacer axialement en direction de la tête 14 et une partie du produit P présent dans le compartiment 22 du récipient est forcée à travers l'orifice 18 du récipient et l'orifice 58 de l'organe de distribution. Ceci provoque le déplacement du piston 36 à l'intérieur de l'organe de distribution 34 en direction de l'orifice de sortie 42 de la tête de distribution comme cela est illustré à la figure 10.  In the position illustrated in Figure 9, under the effect of the force exerted by the spring 30, the piston 20 can then move axially towards the head 14 and a portion of the product P present in the compartment 22 of the container is forced through the orifice 18 of the container and the orifice 58 of the dispenser member. This causes the piston 36 to move inside the dispensing member 34 in the direction of the outlet orifice 42 of the dispensing head as shown in FIG.
Ainsi, la chambre de dosage 62 se crée à nouveau et se remplit en produit P issu du compartiment 22 du récipient. Simultanément, le volume de la chambre de dosage 60 opposée diminue et le produit déjà présent dans cette chambre est distribué à travers l'orifice de sortie 42. L'augmentation de volume de la chambre de dosage 62 et son remplissage, ainsi que la distribution simultanée du produit au travers de l'orifice de sortie 42 continuent jusqu'à ce que la tête 66 du piston vienne en butée contre le corps 48 de l'organe de distribution comme cela est illustré à la figure 11. La distribution du produit est continue pendant le vidage de la chambre de dosage 60.  Thus, the metering chamber 62 is created again and fills P product from the compartment 22 of the container. Simultaneously, the volume of the opposite metering chamber 60 decreases and the product already present in this chamber is distributed through the outlet orifice 42. The volume increase of the metering chamber 62 and its filling, as well as the distribution simultaneous product through the outlet port 42 continue until the head 66 of the piston abuts against the body 48 of the dispenser member as shown in Figure 11. The distribution of the product is continues during the emptying of the metering chamber 60.
Avec le dispositif de l'invention, la mise en communication du compartiment 22 à volume variable du récipient avec l'un des orifices 56, 58 de l'organe de distribution provoque le déplacement du piston 36, ce qui permet d'obtenir simultanément une entrée du produit P du compartiment 22 dans la chambre de dosage 60, 62 en communication avec cet orifice, et une distribution du produit déj à présent dans l ' autre chambre de dosage au travers de l ' orifice 42 de sortie de la tête de distribution. On obtient ainsi un dosage précis et reproductible de la quantité de produit à délivrer à chaque utilisation du dispositif. With the device of the invention, the placing in communication of the compartment 22 of variable volume of the container with one of the orifices 56, 58 of the dispensing member causes the displacement of the piston 36, which makes it possible simultaneously to obtain a entrance to product P of the compartment 22 in the metering chamber 60, 62 in communication with this orifice, and a distribution of the product already in the other metering chamber through the outlet orifice 42 of the dispensing head. This gives a precise and reproducible dosage of the amount of product to be delivered each time the device is used.
Par ailleurs, la quantité de produit à délivrer peut être ajustée . En effet, comme indiqué précédemment, chaque tête 66, 68 du piston est fixée de manière réglable sur la tige 64, ce qui permet de les rapprocher ou de les éloigner l 'une par rapport à l ' autre selon les vo lumes souhaités des première et deuxième chambres de dosage 60, 62 lors de la distribution du produit. Par exemple, par rapport à la position illustrée à la figure 12, les têtes 66, 68 du piston peuvent être dévissées, tout en restant en prise avec la tige 64, de sorte à réduire le vo lume de la chambre de dosage 62 comme illustré à la figure 13.  Moreover, the quantity of product to be delivered can be adjusted. Indeed, as indicated above, each piston head 66, 68 is adjustably attached to the rod 64, which allows them to be brought closer to one another or away from one another in accordance with the desired values of the first and second dosing chambers 60, 62 when dispensing the product. For example, with respect to the position illustrated in FIG. 12, the piston heads 66, 68 can be unscrewed, while remaining in engagement with the rod 64, so as to reduce the volume of the metering chamber 62 as illustrated. in figure 13.
L ' ajustement du vo lume de dosage des chambres 60, 62 peut être réalisé lors de l ' assemblage du dispositif en fonction du produit destiné à être stocké et distribué. Il est aussi possible de laisser la possibilité à l 'utilisateur de réaliser cet ajustement du vo lume des chambres 60, 62 par exemple à l ' aide d'une clé fournie avec le dispositif et prévue pour venir s 'insérer à l ' intérieur d'un logement de forme complémentaire ménagé sur chaque face frontale des têtes 66, 68 du piston pour assurer le vissage ou dévissage de ces têtes . Cette clé est dimensionnée pour pouvoir être introduite à travers les orifices 42 et 56 ou 58 de sorte à réaliser cet ajustement du vo lume de dosage des chambres 60, 62 depuis l ' extérieur du dispositif 10.  The adjustment of the dosing volume of the chambers 60, 62 can be made during assembly of the device according to the product to be stored and dispensed. It is also possible to allow the user to perform this adjustment of the volume of the chambers 60, 62 for example by means of a key provided with the device and intended to be inserted inside the chamber. a housing of complementary shape formed on each end face of the heads 66, 68 of the piston to ensure the screwing or unscrewing of these heads. This key is dimensioned so that it can be introduced through the orifices 42 and 56 or 58 so as to make this adjustment of the volume of metering of the chambers 60, 62 from the outside of the device 10.

Claims

REVENDICATIONS
1 . Dispositif de conditionnement et de distribution d'un produit, notamment d'un produit pharmaceutique ou cosmétique, comprenant un récipient ( 12) de stockage pourvu d' au moins un compartiment (22) à vo lume variable contenant ledit produit, un moyen de pressurisation (30) apte à pressuriser de façon permanente le produit contenu dans ledit compartiment, et une tête de distribution ( 14) comprenant une embase de montage (32) fixée sur le récipient, caractérisé en ce que la tête de distribution comprend en outre : 1. Device for packaging and dispensing a product, in particular a pharmaceutical or cosmetic product, comprising a storage container (12) provided with at least one variable-volume compartment (22) containing said product, a pressurizing means Device (30) capable of permanently pressurizing the product contained in said compartment, and a dispensing head (14) comprising a mounting base (32) fixed to the container, characterized in that the dispensing head further comprises:
un organe de distribution (34) monté à l ' intérieur de l ' embase de montage (32) en étant mobile à rotation,  a dispensing member (34) mounted within the mounting base (32) being rotatably movable,
un piston (36) mobile en translation à l' intérieur de l ' organe de distribution (34) et apte à délimiter à l' intérieur dudit organe des première et deuxième chambres de dosage (60, 62) opposées, et  a piston (36) movable in translation within the dispensing member (34) and capable of delimiting inside said member first and second opposite metering chambers (60, 62), and
au moins des premier et deuxième orifices (56, 58) ménagés sur l ' organe de distribution (34) et respectivement aptes à être en communication fluidique directe avec les première et deuxième chambres de dosage (60, 62),  at least first and second orifices (56, 58) provided on the dispensing member (34) and respectively adapted to be in direct fluid communication with the first and second dosing chambers (60, 62),
l ' organe de distribution (34) étant mobile au mo ins entre une première position dans laquelle ledit premier orifice (56) est en communication fluidique avec le compartiment (22) à vo lume variable du récipient et dans laquelle ledit deuxième orifice (58) est en communication fluidique avec au moins un orifice de sortie (42) de la tête de distribution, et une deuxième position dans laquelle ledit deuxième orifice (58) est en communication fluidique avec ledit compartiment (22) à vo lume variable et dans laquelle ledit premier orifice (56) est en communication fluidique avec ledit orifice de sortie (42) .  the dispensing member (34) being movable at least between a first position in which said first port (56) is in fluid communication with the variable volume compartment (22) of the container and wherein said second port (58) is in fluid communication with at least one outlet port (42) of the dispensing head, and a second position in which said second port (58) is in fluid communication with said variable volume compartment (22) and wherein said first port (56) is in fluid communication with said outlet port (42).
2. Dispositif selon la revendication 1 , dans lequel le piston (36) comprend des moyens pour régler avant utilisation le vo lume maximal de chacune des première et deuxième chambres de dosage (60, 62) . The device of claim 1, wherein the piston (36) comprises means for adjusting before use the maximum volume of each of the first and second dosing chambers (60, 62).
3. Dispositif selon la revendication 2, dans lequel le piston comprend une tige (64) sur laquelle est fixée de manière réglable à chaque extrémité une tête de piston (66, 68) . 3. Device according to claim 2, wherein the piston comprises a rod (64) on which is fixed adjustably at each end a piston head (66, 68).
4. Dispositif selon la revendication 3 , dans lequel chaque extrémité de la tige (64) comprend un filetage en prise avec un filetage de la tête de piston (66, 68) associée.  4. The device of claim 3, wherein each end of the rod (64) comprises threads engaged with a thread of the associated piston head (66, 68).
5. Dispositif selon l 'une quelconque des revendications précédentes, dans lequel l ' organe de distribution (34) est mobile à rotation autour d'un axe géométrique transversal à un axe (Χ-Χ ' ) longitudinal du récipient ( 12) de stockage.  5. Device according to any one of the preceding claims, wherein the dispensing member (34) is rotatable about a geometric axis transverse to a longitudinal axis (Χ-Χ ') of the storage container (12). .
6. Dispositif selon l 'une quelconque des revendications précédentes, dans lequel ledit orifice de sortie (42) est ménagé sur l ' embase de montage (32) .  Apparatus according to any one of the preceding claims, wherein said outlet (42) is provided on the mounting base (32).
7. Dispositif selon l 'une quelconque des revendications précédentes, dans lequel ledit orifice de sortie (42) présente une section transversale de forme oblongue et dont la plus petite dimension est inférieure à la plus grande dimension de la section du piston (36) .  7. Device according to any one of the preceding claims, wherein said outlet orifice (42) has a cross section of oblong shape and whose smaller dimension is smaller than the largest dimension of the section of the piston (36).
8. Dispositif selon l 'une quelconque des revendications précédentes, dans lequel l 'organe de distribution (34) comprend un moyen d ' actionnement (70) accessible depuis l' extérieur de l ' embase de montage (32) .  8. Device according to any one of the preceding claims, wherein the dispensing member (34) comprises an actuating means (70) accessible from the outside of the mounting base (32).
9. Dispositif selon l 'une quelconque des revendications précédentes, dans lequel l ' organe de distribution (34) comprend des moyens pour repérer la position des premier et deuxième orifices (56 , 58) .  9. Device according to any one of the preceding claims, wherein the dispensing member (34) comprises means for locating the position of the first and second orifices (56, 58).
10. Dispositif selon l 'une quelconque des revendications précédentes, dans lequel l ' embase de montage (32) se présente sous la forme de deux coques (38 , 40) articulées qui recouvrent et qui maintiennent en position l ' organe de distribution (34) .  10. Device according to any one of the preceding claims, wherein the mounting base (32) is in the form of two hinged shells (38, 40) which cover and hold in position the dispensing member (34). ).
1 1 . Dispositif selon l 'une quelconque des revendications précédentes, dans lequel le moyen de pressurisation (30) est disposé à l' intérieur d'un compartiment (24) additionnel à vo lume variable du récipient de stockage. 1 1. Apparatus according to any one of the preceding claims, wherein the pressurizing means (30) is disposed within an additional compartment (24) of variable volume of the storage container.
12. Dispositif selon la revendication 1 1 , dans lequel le récipient ( 12) de stockage comprend une cloison de séparation délimitant de manière étanche le compartiment (22) à vo lume variable contenant ledit produit et le compartiment (24) à volume variable additionnel. The device of claim 11, wherein the storage container (12) comprises a partition wall sealingly delimiting the variable volume compartment (22) containing said product and the additional variable volume compartment (24).
13. Dispositif selon la revendication 12, dans laquelle la cloison de séparation est réalisée sous la forme d'un piston (20) mobile à l ' intérieur du récipient de stockage.  13. Device according to claim 12, wherein the partition wall is made in the form of a piston (20) movable inside the storage container.
14. Dispositif selon la revendication 13 , dans lequel le moyen de pressurisation (30) comprend un organe mécanique déformable élastiquement et exerçant un effort de poussée permanent sur le piston (20) en direction de la tête de distribution ( 14) .  14. Device according to claim 13, wherein the pressurizing means (30) comprises a resiliently deformable mechanical member and exerting a permanent thrust force on the piston (20) in the direction of the dispensing head (14).
15. Dispositif selon la revendication 12, dans laquelle la cloison de séparation est réalisée sous la forme d'une poche à parois souples.  15. Device according to claim 12, wherein the partition wall is made in the form of a flexible-walled pocket.
EP18724602.0A 2017-06-23 2018-05-23 Device for packaging and dispensing a product, notably a pharmaceutical or cosmetic product Withdrawn EP3642571A1 (en)

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FR1755759A FR3068019B1 (en) 2017-06-23 2017-06-23 DEVICE FOR PACKAGING AND DISPENSING A PRODUCT, IN PARTICULAR A PHARMACEUTICAL OR COSMETIC PRODUCT
PCT/EP2018/063536 WO2018233967A1 (en) 2017-06-23 2018-05-23 Device for packaging and dispensing a product, notably a pharmaceutical or cosmetic product

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US11679403B1 (en) 2022-02-02 2023-06-20 Ries Ries Inc Travel dispenser for dispensing a fluid

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US20200103266A1 (en) 2020-04-02
FR3068019A1 (en) 2018-12-28
FR3068019B1 (en) 2019-08-23
US11162831B2 (en) 2021-11-02
WO2018233967A1 (en) 2018-12-27

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