EP3604306A4 - Makrocyclisches derivat von pyrazol[3,4-d]pyrimidin-3-on, pharmazeutische zusammensetzung und verwendung davon - Google Patents
Makrocyclisches derivat von pyrazol[3,4-d]pyrimidin-3-on, pharmazeutische zusammensetzung und verwendung davon Download PDFInfo
- Publication number
- EP3604306A4 EP3604306A4 EP18772694.8A EP18772694A EP3604306A4 EP 3604306 A4 EP3604306 A4 EP 3604306A4 EP 18772694 A EP18772694 A EP 18772694A EP 3604306 A4 EP3604306 A4 EP 3604306A4
- Authority
- EP
- European Patent Office
- Prior art keywords
- pyrazol
- pyrimidin
- pharmaceutical composition
- macrocyclic derivative
- macrocyclic
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- TVOBVNNUECNRHY-UHFFFAOYSA-N 1-[6-(2-hydroxypropan-2-yl)pyridin-2-yl]-6-(4-morpholin-4-ylanilino)-2-prop-2-enylpyrazolo[3,4-d]pyrimidin-3-one Chemical compound CC(C)(O)c1cccc(n1)-n1n(CC=C)c(=O)c2cnc(Nc3ccc(cc3)N3CCOCC3)nc12 TVOBVNNUECNRHY-UHFFFAOYSA-N 0.000 title 1
- WTKZEGDFNFYCGP-UHFFFAOYSA-N Pyrazole Chemical class C=1C=NNC=1 WTKZEGDFNFYCGP-UHFFFAOYSA-N 0.000 title 1
- 239000008194 pharmaceutical composition Substances 0.000 title 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D498/12—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains three hetero rings
- C07D498/18—Bridged systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D498/22—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains four or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/12—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains three hetero rings
- C07D487/18—Bridged systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D519/00—Heterocyclic compounds containing more than one system of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring system not provided for in groups C07D453/00 or C07D455/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
Applications Claiming Priority (5)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
CN201710179860 | 2017-03-23 | ||
CN201710741306 | 2017-08-25 | ||
CN201710853561 | 2017-09-20 | ||
CN201810012312 | 2018-01-05 | ||
PCT/CN2018/079866 WO2018171633A1 (zh) | 2017-03-23 | 2018-03-21 | 吡唑[3,4-d]嘧啶-3-酮的大环衍生物、其药物组合物及应用 |
Publications (3)
Publication Number | Publication Date |
---|---|
EP3604306A1 EP3604306A1 (de) | 2020-02-05 |
EP3604306A4 true EP3604306A4 (de) | 2020-12-09 |
EP3604306B1 EP3604306B1 (de) | 2022-10-26 |
Family
ID=63585896
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
EP18772694.8A Active EP3604306B1 (de) | 2017-03-23 | 2018-03-21 | Makrocyclisches derivat von pyrazol[3,4-d]pyrimidin-3-on, pharmazeutische zusammensetzung und dessen verwendung |
Country Status (5)
Country | Link |
---|---|
US (1) | US11248006B2 (de) |
EP (1) | EP3604306B1 (de) |
JP (1) | JP7140337B2 (de) |
CN (1) | CN108623615B (de) |
WO (1) | WO2018171633A1 (de) |
Families Citing this family (16)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US11299493B2 (en) | 2017-10-09 | 2022-04-12 | Nuvation Bio Inc. | Heterocyclic compounds and uses thereof |
CA3078945A1 (en) | 2017-10-09 | 2019-04-18 | Nuvation Bo Inc. | Heterocyclic compounds and uses thereof |
CA3080842A1 (en) * | 2017-11-01 | 2019-05-09 | Shijiazhuang Sagacity New Drug Development Co., Ltd. | Macrocyclic compound serving as weel inhibitor and applications thereof |
IL276802B2 (en) | 2018-03-09 | 2023-09-01 | Recurium Ip Holdings Llc | Transduced 2,1-dihydro-3h-pyrazolo[4,3-d]pyrimidine-3-ones |
WO2020083404A1 (zh) * | 2018-10-26 | 2020-04-30 | 南京明德新药研发有限公司 | 作为Wee1抑制剂的嘧啶并吡唑酮类衍生物及其应用 |
WO2020192581A1 (zh) | 2019-03-22 | 2020-10-01 | 首药控股(北京)有限公司 | Wee1抑制剂及其制备和用途 |
WO2020210381A1 (en) * | 2019-04-09 | 2020-10-15 | Nuvation Bio Inc. | Heterocyclic compounds and uses thereof |
BR112021019703A2 (pt) | 2019-04-09 | 2021-12-14 | Nuvation Bio Inc | Compostos heterocíclicos e usos dos mesmos |
EP3952875A4 (de) * | 2019-04-09 | 2022-12-28 | Nuvation Bio Inc. | Heterocyclische verbindungen und verwendungen davon |
JP2022530812A (ja) * | 2019-04-30 | 2022-07-01 | シージャーヂュアン・サガシティー・ニュー・ドラッグ・デヴェロップメント・カンパニー・リミテッド | Wee1阻害剤化合物の結晶形及びその応用 |
CN113387962A (zh) * | 2020-03-12 | 2021-09-14 | 上海迪诺医药科技有限公司 | 吡唑并[3,4-d]嘧啶-3-酮衍生物、其药物组合物及应用 |
WO2021254389A1 (zh) * | 2020-06-17 | 2021-12-23 | 微境生物医药科技(上海)有限公司 | 作为Wee-1抑制剂的吡唑并[3,4-d]嘧啶-3-酮衍生物 |
CN115197221A (zh) * | 2021-04-02 | 2022-10-18 | 轩竹生物科技股份有限公司 | 二氢吡唑并嘧啶酮类大环衍生物及其用途 |
WO2023016417A1 (zh) * | 2021-08-11 | 2023-02-16 | 微境生物医药科技(上海)有限公司 | 作为Wee-1抑制剂的1,2-二氢-3H-吡唑[3,4-d]嘧啶-3-酮化合物 |
WO2023041066A1 (zh) * | 2021-09-18 | 2023-03-23 | 优领医药科技(香港)有限公司 | 含嘧啶并二氢吡唑啉酮类衍生物、其药学上可接受的盐及其制备方法和应用 |
CN116462687A (zh) | 2022-01-18 | 2023-07-21 | 江苏天士力帝益药业有限公司 | Wee1抑制剂及其制备和用途 |
Citations (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP3712150A1 (de) * | 2017-11-01 | 2020-09-23 | Shijiazhuang Sagacity New Drug Development Co., Ltd. | Makrozyklische verbindung als wee1-inhibitor und anwendungen davon |
Family Cites Families (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US20050096324A1 (en) * | 2003-11-05 | 2005-05-05 | Zhi-Fu Tao | Macrocyclic kinase inhibitors |
US7163939B2 (en) * | 2003-11-05 | 2007-01-16 | Abbott Laboratories | Macrocyclic kinase inhibitors |
PE20080695A1 (es) * | 2006-04-27 | 2008-06-28 | Banyu Pharma Co Ltd | Derivados de dihidropirazolopirimidinona como inhibidores de quinasa weel |
JPWO2009054332A1 (ja) * | 2007-10-23 | 2011-03-03 | 萬有製薬株式会社 | ピリドン置換ジヒドロピラゾロピリミジノン誘導体 |
AU2016344040B2 (en) * | 2015-11-01 | 2020-12-10 | The Regents Of The University Of Colorado, A Body Corporate | Wee 1 kinase inhibitors and methods of making and using the same |
-
2018
- 2018-03-21 US US16/496,534 patent/US11248006B2/en active Active
- 2018-03-21 JP JP2019552608A patent/JP7140337B2/ja active Active
- 2018-03-21 EP EP18772694.8A patent/EP3604306B1/de active Active
- 2018-03-21 WO PCT/CN2018/079866 patent/WO2018171633A1/zh unknown
- 2018-03-21 CN CN201810232314.2A patent/CN108623615B/zh active Active
Patent Citations (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP3712150A1 (de) * | 2017-11-01 | 2020-09-23 | Shijiazhuang Sagacity New Drug Development Co., Ltd. | Makrozyklische verbindung als wee1-inhibitor und anwendungen davon |
Also Published As
Publication number | Publication date |
---|---|
WO2018171633A1 (zh) | 2018-09-27 |
US11248006B2 (en) | 2022-02-15 |
CN108623615B (zh) | 2022-12-13 |
EP3604306B1 (de) | 2022-10-26 |
EP3604306A1 (de) | 2020-02-05 |
JP7140337B2 (ja) | 2022-09-21 |
US20200377520A1 (en) | 2020-12-03 |
CN108623615A (zh) | 2018-10-09 |
JP2020511520A (ja) | 2020-04-16 |
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