EP3554707A1 - Fixation et séparation d'un ensemble piston-cylindre sur/d'un dispositif servant à aspirer et à expulser des volumes de fluide - Google Patents

Fixation et séparation d'un ensemble piston-cylindre sur/d'un dispositif servant à aspirer et à expulser des volumes de fluide

Info

Publication number
EP3554707A1
EP3554707A1 EP18706712.9A EP18706712A EP3554707A1 EP 3554707 A1 EP3554707 A1 EP 3554707A1 EP 18706712 A EP18706712 A EP 18706712A EP 3554707 A1 EP3554707 A1 EP 3554707A1
Authority
EP
European Patent Office
Prior art keywords
piston
dispenser
cylinder
cylinder unit
locking element
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
EP18706712.9A
Other languages
German (de)
English (en)
Other versions
EP3554707B1 (fr
Inventor
Jürgen Schraut
Daniel Setzer
Renate Rempt
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Brand GmbH and Co KG
Original Assignee
Brand GmbH and Co KG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Brand GmbH and Co KG filed Critical Brand GmbH and Co KG
Publication of EP3554707A1 publication Critical patent/EP3554707A1/fr
Application granted granted Critical
Publication of EP3554707B1 publication Critical patent/EP3554707B1/fr
Active legal-status Critical Current
Anticipated expiration legal-status Critical

Links

Classifications

    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
    • B01L3/02—Burettes; Pipettes
    • B01L3/021—Pipettes, i.e. with only one conduit for withdrawing and redistributing liquids
    • B01L3/0217—Pipettes, i.e. with only one conduit for withdrawing and redistributing liquids of the plunger pump type
    • B01L3/0234—Repeating pipettes, i.e. for dispensing multiple doses from a single charge
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2200/00—Solutions for specific problems relating to chemical or physical laboratory apparatus
    • B01L2200/14—Process control and prevention of errors
    • B01L2200/143—Quality control, feedback systems
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00—Additional constructional details
    • B01L2300/02—Identification, exchange or storage of information
    • B01L2300/021—Identification, e.g. bar codes
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2400/00—Moving or stopping fluids
    • B01L2400/04—Moving fluids with specific forces or mechanical means
    • B01L2400/0475—Moving fluids with specific forces or mechanical means specific mechanical means and fluid pressure
    • B01L2400/0478—Moving fluids with specific forces or mechanical means specific mechanical means and fluid pressure pistons
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
    • B01L3/02—Burettes; Pipettes
    • B01L3/0275—Interchangeable or disposable dispensing tips
    • B01L3/0279—Interchangeable or disposable dispensing tips co-operating with positive ejection means

Definitions

  • the invention relates to a dispenser for receiving and dispensing fluid volumes according to the preamble of claim 1.
  • the invention also relates to a system for receiving and dispensing fluid volumes according to the preamble of claim 19, a method for releasably attaching a piston-cylinder unit to a dispenser according to claim 20 and a method for releasing a piston-cylinder device attached to a dispenser. Unit according to claim 27.
  • Task of systems of the type in question is to receive a fluid volume from a container and then deliver it to another or more other container.
  • Such systems are used in particular for the repeated dispensing, titration or pipetting of liquids.
  • Such systems comprise a dispenser and a piston-cylinder unit designed as a replacement part, which can be detachably attached to the dispenser, in particular can be inserted or inserted into the dispenser. After one or more dispensing operations, the piston-cylinder unit can be released from the dispenser. Subsequently, another, in particular different piston-cylinder unit can be attached to the dispenser.
  • Piston-cylinder units of the type in question can z. B. be designed as displacement units with attachable pipettes or tips (Tips) or as syringes. They each have a cylinder, in particular with a straight hollow cylinder with a substantially circular cross-section and a perpendicular to the axial direction, and a displaceable in the cylinder in the axial direction piston. Piston-cylinder units have different sized cross sections and / or lengths depending on the type.
  • piston-cylinder units can be attached to the dispenser by means of a movement running at least substantially in the axial direction of the dispenser.
  • dispenser axial direction refers to an alignment coincident with or parallel to the longitudinal axis of the dispenser.
  • piston-cylinder units which operate on the Miniverdrlindungscream, and motor-driven, electronic multi-dispensers.
  • the actuation of one or more keys initiates a pick-up or dispensing mechanism.
  • the piston of a piston-cylinder unit attached to the dispenser is moved by means of a motor which controls volume delivery by a microprocessor.
  • the piston seals the inner wall of the cylinder of the piston-cylinder unit from sealing, so that exactly reproducible volume results can be achieved.
  • a dispenser for receiving and dispensing fluid volumes is known, to which a piston-cylinder unit with a piston and a cylinder by means of at least substantially extending in the axial direction of the dispenser movement is detachably attachable.
  • the known dispenser has a piston actuator for moving the piston relative to the cylinder.
  • the piston actuator is movably disposed in the dispenser and driven by an electric motor. It is therefore a motorized, electronic dispenser.
  • the known dispenser has a housing and a stop element and is designed so that when attaching the piston-cylinder unit to the dispenser, a mounting portion of the cylinder can be brought into contact with the stop element.
  • the attachment portion of the cylinder is formed by a flange, so an annular broadening of the cylinder at one end of the cylinder.
  • the known dispenser also has a first attachment means for fixing the cylinder to the dispenser.
  • the first fastening device has two Zylindergreifhebel and is movable in a fixing position in which the first fastening means blocks a relative movement between the cylinder and the housing in the axial direction.
  • the known dispenser also has a second attachment means for fixing the piston to the dispenser.
  • the second attachment means has two piston gripping levers and is movable to a fixing position in which the piston is releasably connected to the piston actuator such that the piston is movable relative to the cylinder for receiving and / or dispensing fluid volumes by means of the piston actuator.
  • the first fastening device of the dispenser engages behind the flange of the cylinder.
  • the cylinder is held in a form-fitting manner on the dispenser in the axial direction.
  • the second fastening device When moving the piston-cylinder unit in the direction of the stop element relative to the housing of the dispenser also the second fastening device is moved by a flange of the piston from the fixing position, so that the piston is further movable into the dispenser.
  • the piston gripping levers of the second fastening device are pressed radially outwards by the flange of the piston. If the piston has been moved far enough into the dispenser, the second attachment device of the dispenser, in particular with its piston gripping levers, engages behind the flange of the piston. Thus, the piston is held in the axial direction positively on the dispenser.
  • the piston gripping levers are coupled in terms of movement with the piston actuator. Accordingly, after the engagement of the flange of the piston, the piston for receiving and / or discharging fluid volumes can be moved relative to the cylinder by means of the piston actuator.
  • the first and second fastening means are manually operated such that the Zylindergreifhebel and the piston gripping levers are pressed radially outward until the cylinder and the piston are no longer held in a form-fitting manner on the dispenser. Subsequently, the piston-cylinder unit can be separated from the dispenser.
  • An object of the present invention is the known dispenser or the known system or the known method for releasably attaching the piston-cylinder unit to the known dispenser or the known method for releasing a mounted on the dispenser piston-cylinder unit in terms the handling and / or stability in mounting and / or releasing the piston-cylinder unit and / or to improve the accuracy in recording and dispensing fluid volumes and / or in structure, reliability and / or durability.
  • the above-described task is solved by the dispenser according to claim 1.
  • Preferred embodiments of this aspect of the invention are the subject of the relevant subclaims.
  • the basis of the first aspect of the invention is a dispenser for receiving and dispensing fluid volumes, to which a piston-cylinder unit with a piston and a cylinder can be detachably attached by means of a movement extending at least substantially in the axial direction of the dispenser.
  • the dispenser has a piston actuator for moving the piston relative to the cylinder.
  • the piston actuator is movably disposed in the dispenser and driven by a drive.
  • the dispenser has a locking element, which is movably arranged in the dispenser and driven by means of a drive.
  • the drive of the locking element is separate from the drive of the piston actuator.
  • the locking element is arranged to be movable in the axial direction and movable in different positions.
  • elements or devices of the dispenser are movable.
  • the other elements or devices are not necessarily moved by the locking element itself.
  • a movement of the locking element is a cause for the movement of the further elements or devices.
  • moving the locking element may cause a previously motion-blocked element to be moved with or after moving the locking element, such as moving that element e.g. B. can be effected by the spring force of a spring element.
  • the locking element itself moves a further element or another device by its movement. It is advantageous that the elements or devices do not have to be moved manually, but are automatically moved at the behest of a user and / or a control device of the dispenser. This allows a comfortable handling of the dispenser.
  • the drive of the locking element is an electric stepping motor.
  • the locking element is driven by means of its drive via a self-locking gear.
  • the dispenser has a housing, a stop element and a first fastening device for fixing the cylinder to the dispenser.
  • the stop element is movable at least substantially in the axial direction relative to the housing and can be pressed relative to the housing at least partially in the attachment direction. This allows further movement of the cylinder in the mounting direction relative to the housing after the attachment portion of the cylinder bears against the stop element. Thus, an overpressure of the cylinder when mounting the piston-cylinder unit is possible.
  • the dispenser is designed so that when attaching the piston-cylinder unit on the dispenser, a mounting portion of the cylinder can be brought into contact with the stop element.
  • the first fastening device is movable into a fixing position, in which the first fastening device blocks a relative movement between the cylinder and the housing counter to the mounting direction.
  • the locking element is movable into a locking position in which the locking element blocks a relative movement between the stop element and the housing in the mounting direction.
  • the stopper element is lockable. A relative movement between the stop element and the housing in the axial direction is blocked by the locking element on the one hand and by the first fastening device on the other hand, that is not possible.
  • the fastening section prevents the stop element from being moved in the mounting direction in such a way that the cylinder slips or warp, causing the desired position to be absorbed Fluid volume deviates from the actually recorded fluid volume. This leads to an increase in accuracy when receiving and dispensing fluid volumes.
  • the fastening portion of the cylinder between the first fastening device and the stop element is clamped such that a relative movement between the cylinder and the housing in the axial direction, and optionally in the radial direction and / or circumferential direction is blocked.
  • the dispenser has means for mechanical, electronic, inductive and / or optical detection of the attachment of a piston-cylinder unit on the dispenser. This detection allows the triggering of further steps, eg. B. moving the locking element.
  • the dispenser can have an optical, electronic, mechanical, magnetoresistive and / or inductive sensor device by means of which the movement of the stop element in the axial direction can be detected.
  • the sensor device can, for. B. a light barrier with a light beam source and a sensor for detecting light rays of the light beam source, wherein the light barrier is arranged so that a movement of the stop element in the axial direction of the light barrier is detectable.
  • the dispenser has a rear part, which exerts a restoring force on the stop element at least substantially in the axial direction against the mounting direction. If the attachment portion of the cylinder abuts on the stop element and the locking element is not in its locking position, the movement of the cylinder in the mounting direction relative to the housing must be carried out against the restoring force of the back device. As a result, tolerances of the stop element of the dispenser or the attachment portion of the cylinder are compensated and damage or wear and tear of the dispenser or cylinder avoided or at least reduced.
  • the stop element is pivotally mounted or tiltably mounted on the dispenser, in particular at exactly one bearing.
  • the pivoting or tilting axis may be oriented so that it is perpendicular and skewed to the longitudinal axis of the dispenser. It is preferred if the rear part device is arranged diametrically opposite the bearing of the stop element in the radial direction.
  • the stop element runs around in the circumferential direction and / or has a passage for the piston.
  • the rear subassembly has a spring element, in particular exactly one spring element, whose spring force as the restoring force of Returning device acts on the stop element. This allows a simple, robust, reliable and cost-effective implementation of the rear part.
  • the rear part device has a bolt which rotates around the spring element.
  • the bolt and / or the spring element can be supported against the housing of the dispenser.
  • the stop element may be arranged on the bolt so that it is guided along the bolt during movement of the stop element.
  • the dispenser and its rear part device are designed such that a piston-cylinder unit attached to the dispenser can be separated from the dispenser by means of the rear part device.
  • the rear part device thus facilitates an automatic separation or ejection of the piston-cylinder unit from the dispenser, after the first fastening device has been moved from its fixing position into a release parting, in which a relative movement between the cylinder and the housing against the mounting direction is executable.
  • the dispenser is designed in such a way that in the release division of the first fastening device, the piston-cylinder unit can be disconnected and / or thrown off the dispenser unhindered.
  • the dispenser has a housing and a first fastening device for fixing the cylinder to the dispenser.
  • the first fastening device is movable into a fixing position, in which the first fastening device blocks a relative movement between the cylinder and the housing counter to the mounting direction.
  • the first fastening device of the dispenser by moving the locking element, in particular in the axial direction, from its fixing position into a release pitch movable in which a relative movement between the cylinder and the housing against the mounting direction is executable.
  • the release division of the locking element the mobility of the stop element is thus unaffected by the locking element.
  • the dispenser according to the invention allows easy handling, in particular a comfortable release and / or separation of a piston-cylinder unit from the dispenser.
  • the first attachment means comprises at least two pivotally mounted Zylindergreifhebel, which can engage behind the attachment portion of the cylinder in the fixing position of the first fastening means.
  • the dispenser has a second fastening device for fixing the piston to the dispenser.
  • the second attachment means is movable to a fixation position in which the piston is releasably connected to a piston actuator of the dispenser such that the piston is movable relative to the cylinder for receiving and / or dispensing fluid volumes via the piston actuator.
  • the second fastening device may have at least two pivotally mounted piston gripping levers.
  • the second fastening device is movable by moving the locking element from its fixing position into a release position and vice versa, wherein the piston is not connected to the piston actuator in the release position of the second fastening device.
  • the second fastening device is preferably coupled in terms of movement to the piston actuator and, in its fixing position over the entire path that it can perform when the piston actuator moves, can be guided by the locking element such that it remains in its fixing position.
  • the second fastening device preferably has two pivotally mounted piston gripping levers with cutting rollers, wherein the piston can be gripped by means of the piston gripping lever when the second fastening device moves into its fixing position.
  • each piston gripping lever having an actuating head, by means of which the respective piston gripping lever is pivotable.
  • Each actuator is at Move the Verhegelungselements and / or the piston actuator guided on a guide contour of the locking element.
  • the extension of the guide contour in the axial direction is greater than the stroke that can be executed by the piston actuator. This prevents a loosening of the second fastening device, in particular by turning the piston-cylinder unit.
  • the dispenser has a detection device for automatically identifying the type of a piston-cylinder unit attached to the dispenser.
  • the detection device has a radial information reader, by means of which information of a radially oriented information carrier section of the piston-cylinder unit can be detected.
  • the detection device has an axial information reader, by means of which information of an axially aligned information carrier section of the piston-cylinder unit can be detected.
  • At least a part of the radial information reader and / or at least a part of the axial information reader is / are movable by moving the locking element.
  • the locking member at least a portion of the radial information reader in a radially extending recess on a piston head of the piston-cylinder unit in the radial direction and / or at least a portion of the Axialinformationslesers in an axially extending recess, in particular groove, in one End face of a piston head of the piston-cylinder unit inserted in the axial direction.
  • the axial information reader has a detection element which is at least partially insertable into the axially aligned recess in the axial direction.
  • the dispenser has means by which the depth of the recess can be determined.
  • the depth of the recess at least partially specifies the type of piston-cylinder unit.
  • type z. B. a purpose, a state and / or a property of the piston-cylinder unit, such as. B. the maximum recordable and / or deliverable fluid volume.
  • axially aligned recess is to be understood as meaning that this recess can be accessed in the axial direction of the piston-cylinder unit and / or its information can be detected in the axial direction of the piston-cylinder unit Direction of the piston-cylinder unit, a geometric extent, by means of which the detectable information of the axially aligned recess is encoded .
  • the axially aligned recess has a geometric extension in the radial direction of the piston-cylinder unit and in the circumferential direction of the piston-cylinder unit ,
  • the term "groove" is to be understood that the recess extending in the axial direction of the piston-cylinder unit in the radial direction of the piston-cylinder unit is not completely surrounded by piston material, but is partially open in the radial direction, preferably along the entire depth Such a configuration facilitates cleaning of the recess and offers a simple means of control
  • the detection element is tappet-like and / or pin-shaped and / or spring-loaded, in particular resiliently biased against the mounting direction of the piston-cylinder unit As soon as the locking element stops blocking the detection element, the spring-loaded detection element is moved towards the piston and finally into the axial direction saving the piston.
  • the piston actuator to the piston in particular a piston head of the piston, to be movable until a stop of the piston actuator abuts an end face of the piston.
  • This movement also referred to as block travel, serves to detect a piston-side reference point.
  • the piston side In particular, the reference point marks the starting point of a determination of the depth of the axially aligned recess of the piston.
  • the locking element is preferably driven by means of a first motor and / or the piston actuator is driven by means of a second motor.
  • the first motor has a lower rated output power than the second motor.
  • the dispenser according to the invention is a completely autonomous, hand-durable device that combines all components regardless of location in a housing.
  • these include, as usual, a transmission device that converts the rotational movement of the drive into a longitudinal movement of the piston actuator, electronics and a power supply.
  • the system according to the second aspect of the invention comprises a designed as a replacement part piston-cylinder unit and a dispenser as described above.
  • the piston-cylinder unit is releasably attachable to the dispenser by means of a movement extending at least substantially in the axial direction and has a piston and a cylinder with a fastening section.
  • the piston-cylinder unit has a piston and a cylinder with a mounting portion.
  • the dispenser has a housing, a stop element, a first attachment device for fixing the cylinder to the dispenser and a locking element.
  • the dispenser is designed as described above.
  • the method comprises the following method steps: a) application of the fastening section of the cylinder of the piston-cylinder unit to the stop element of the dispenser by means of a movement extending at least substantially in the axial direction of the dispenser, b) moving the first fastening device of the dispenser into a fixing position, whereby the cylinder of the piston-cylinder unit is fixed to the dispenser by means of the first fastening device of the dispenser, so that a relative movement between the cylinder of the piston-cylinder unit and the housing of the dispenser is blocked against the mounting direction and optionally in the radial direction, and
  • step a) it can be provided that the piston is moved through a passage of the stop element.
  • a piston actuator of the dispenser can be moved into a release position before step a).
  • the first fastening device engages in the fixing position, the fastening portion of the cylinder by means of at least two pivotally mounted Zylindergreifhebel.
  • the dispenser has detection means for automatically identifying the type of piston-cylinder unit mounted on the dispenser.
  • the detection device has a radial information reader, by means of which information of a radially oriented information carrier section of the piston-cylinder unit can be detected.
  • the detection device has an axial information reader, by means of which information of an axially aligned information carrier section of the piston-cylinder unit can be detected.
  • step c) by moving the locking element, at least part of the radial information reader is inserted into a radially aligned recess on a piston head of the piston-cylinder unit in the radial direction and / or at least one Part of the Axialinformationslesers in an axially aligned recess, in particular groove, is introduced in an end face of a piston head of the piston-cylinder unit in the axial direction / are.
  • movement of the stop element in the attachment direction is detected mechanically, electronically, inductively and / or optically, preferably by means of a light barrier.
  • step c) the locking element of the dispenser is moved, preferably in the axial direction, into a locking position in which a relative movement between the stop element and the housing in the attachment direction is blocked.
  • This step can be performed by the dispenser automatically after detecting a movement of the stop member in the mounting direction.
  • the fixing portion of the cylinder is clamped between the first fastening means and the stopper member, so that relative movement between the cylinder and the housing in the axial direction, and optionally in the radial direction and / or the circumferential direction, is blocked.
  • the cylinder is positively held in the axial direction on the dispenser - between the stop element and the fastening device.
  • a second fastening device of the dispenser for fixing the piston to the dispenser is moved by moving the locking element into a fixing position, in which the piston is detachably connected to a piston actuator of the dispenser in such a way that the piston absorbs and / or discharges of fluid volumes by means of the piston actuator relative to the cylinder is movable.
  • the locking element is moved by means of a first motor and / or the piston actuator by means of a second motor. The movements can be triggered by a user or automatically by the dispenser.
  • a relative movement between the piston and the cylinder can be generated by means of the piston actuator.
  • the distance traveled by the piston relative to the housing of the dispenser can be determined incrementally and / or the absolute path position of a position element of the dispenser, which is coupled in terms of movement with the piston actuator, can be detected.
  • a piston side reference point is detected by moving the piston actuator of the dispenser towards the piston until a stop of the piston actuator abuts an end face of the piston.
  • the path traveled by the piston actuator can be determined, in particular by means of a device for incremental displacement measurement.
  • a detection element of the dispenser is at least partially inserted into an axially aligned recess in an end face of the piston in the axial direction and determines the depth of this recess.
  • the determined depth value can be used to identify the type of piston-cylinder unit.
  • the piston-cylinder unit has a piston and a cylinder.
  • the dispenser has a housing, a first fastening device for fixing the cylinder to the dispenser and a locking element.
  • the dispenser is designed as described above.
  • the method comprises the following method steps:
  • a second fastening device of the dispenser is moved from a fixing position, in which the piston is releasably connected to a piston actuator of the dispenser such that the piston is movable relative to the cylinder for receiving and / or dispensing fluid volumes by means of the piston actuator, is moved to a release position in which the piston is not connected to the piston actuator.
  • the piston-cylinder unit is separated from the dispenser by the restoring force of a rear part of the dispenser on a stop element of the dispenser.
  • Fig. 1 shows a schematic perspective view of a preferred embodiment
  • Fig. 2 shows schematically in a perspective view a preferred
  • FIG. 3 shows schematically in a perspective view a part of the dispenser of Fig. 1, wherein a simplified representation was omitted with omitting parts of the dispenser
  • Fig. 4 schematically shows a vertical longitudinal section through the dispenser
  • Fig. 5 shows schematically a horizontal longitudinal section through the system
  • Fig. 6 schematically shows a horizontal longitudinal section through the system
  • FIG. 7 is a vertical longitudinal section through the system of FIG.
  • Fig. 8 schematically shows a vertical longitudinal section through the system of FIG.
  • Fig. 9 schematically shows a horizontal longitudinal section through the system
  • FIG. 10 shows schematically a vertical longitudinal section through the system of FIG.
  • Fig. 1 1 schematically a horizontal longitudinal section through the system
  • FIG. 12 is a schematic perspective view of the system of FIG. 5 in the third state
  • FIG. Fig. 13 schematically shows a perspective view of the system of Figure 5 in the fifth state, wherein the system is shown partially in section
  • FIG. 12 is a schematic perspective view of the system of FIG. 5 in the third state
  • FIG. Fig. 13 schematically shows a perspective view of the system of Figure 5 in the fifth state, wherein the system is shown partially in section
  • Fig. 14 shows schematically in a perspective view the system of Fig. 5 in the sixth state, wherein the system is shown partially in section.
  • Fig. 1 shows schematically in a perspective view a preferred embodiment of a dispenser 1 according to the invention for receiving and dispensing fluid volumes.
  • the dispenser 1 has a housing 2, an axial direction A and a radial direction R.
  • a piston-cylinder unit 3 is releasably attachable by means of a movement extending at least substantially in the axial direction A of the dispenser 1.
  • the dispenser 1 on an underside 4 on an opening 5 for receiving a portion of the piston-cylinder unit 3.
  • attachment direction designates a direction running at least substantially in the axial direction A of the dispenser 1 toward the opening 5 of the dispenser 1, that is to say from right to left in FIG. 1.
  • the attachment direction F is indicated by an arrow in FIG.
  • Fig. 2 shows schematically in a perspective view the dispenser 1 of Fig. 1 and a piston-cylinder unit 3 as parts of a preferred embodiment of a system 6 according to the invention for receiving and dispensing fluid volumes.
  • the piston-cylinder unit 3 is designed as a replacement part. It may be in the form of a syringe and be present in different sizes with different receiving volume. It has a sealed piston 7, which in a cylinder 8 of the piston-cylinder unit 3 for the purpose of receiving and discharging or ejecting or to be pipetted or dosing liquid is movable.
  • the cylinder 8 has a mounting portion 9, which is here formed by a flange, that is, an annular broadening of the cylinder 8, at that end of the cylinder 8, from which the piston 7 protrudes from the cylinder 8.
  • the flange 9 has a U-shaped profile in longitudinal section, so resembles a collar.
  • FIGS. 3 and 4 show, in a different view, a part of the dispenser 1 from FIG. 1.
  • FIGS. 5 to 14 show different views of the system 6 of FIG. 2 in different states.
  • the dispenser 1 is shown only partially. Namely, Figs. 3 to 14 are limited to the illustration of those components which are required to explain the present invention, respectively.
  • the system of FIG. 2 is cut (in a state other than the initial state) along a plane that intersects the plane of the drawing in a vertical straight line.
  • the system of FIG. 2 is cut (in a state other than the initial state) along a plane which intersects the plane of the drawing in a horizontal straight line.
  • the dispenser 1 has a piston actuator 10 for moving the piston 7 relative to the cylinder 8.
  • the piston actuator 10 is movably disposed in the dispenser 1 and by means of a first drive 1 1, namely a motor 1 1, driven.
  • the dispenser has a locking element 12 which is arranged movably in the dispenser 1 and driven by means of a second drive 13.
  • the second drive 13 of the locking element 12 is separate from the first drive 1 1 of the piston actuator 10th
  • the second drive 13 of the locking element 12 is an electric stepper motor.
  • the locking element 12 is driven by means of its drive 13 via a self-locking gear.
  • the motor 13 has a smaller rated output here as the engine 1 1 of the piston actuator 10. This allows a more cost-effective implementation.
  • the locking element 12 is arranged to be movable in the axial direction A and movable in different positions.
  • Fig. 3 shows the locking element 12 in its basic position.
  • the dispenser 1 has a stop element 14 with a passage 15 for the piston 7 and a first attachment device 16 for fixing the cylinder 8 to the dispenser 1.
  • the stop element 14 is at least substantially in the axial direction A relative to the housing 2 movable and relative to the housing 2 at least partially in the attachment direction F can be pressed.
  • the dispenser 1 is here designed so that when attaching the piston-cylinder unit 3 on the dispenser 1 of the mounting portion 9 of the cylinder 8, and that a contact surface of this mounting portion 9, in abutment with the stop element 14 can be brought.
  • the first fastening device 16 is movable into a fixing position, in which the first fastening device 16 blocks a relative movement between the cylinder 8 and the housing 2 against the mounting direction F.
  • the locking element 12 is in this case movable into a locking position in which the locking element 12 blocks a relative movement between the stop element 14 and the housing 2 in the mounting direction F.
  • the stop element 14 is lockable.
  • the stop member 14 is pivotally mounted on the dispenser 1, to a bearing 17.
  • the pivot axis is aligned so that it is perpendicular to the longitudinal axis of the dispenser 1. Taking the contact surface of the mounting portion 9 of the cylinder 8 as an imaginary circular ring, then the pivot axis passes as aêt radially outside of the annulus, parallel to the annulus and mounting direction F above the annulus and perpendicular to the axial direction A. In Fig. 4, the pivot axis is perpendicular the drawing plane.
  • the dispenser 1 also has a rear-part device 18, which exerts a restoring force on the stop element 14 at least substantially in the axial direction A against the attachment direction F.
  • the rear part device 18 is arranged diametrically opposite the bearing 17 of the stop element 14 in the radial direction R.
  • the rear part device 18 here has exactly one spring element 19 whose spring force acts as a restoring force on the stop element 14.
  • the rear part device 18 has a bolt 20 as a guide for the spring element 19.
  • the bolt 20 extends in the axial direction A.
  • the stop element 14 is arranged on the bolt 20 so that it is guided along the bolt 20 when the stop element 14 is moved.
  • the stop element 14 has a lateral extension 21 with a recess 22 for the bolt 20.
  • the spring element 19 is supported on the extension 21 and against the housing 2ab. Specifically, the stop element 14 by force in the mounting direction F -. B. by a user who applies a piston-cylinder unit 3 to the stop element 14 and then pushes further in the attachment direction F - be moved in just this direction and against the restoring force. If the force falls away - z. B.
  • the first attachment means 16 is movable from its fixing position into a release pitch for the attachment portion 9 by moving the locking member 12 in the attachment direction F in a release position.
  • this release division a relative movement between the cylinder 8 and the housing 2 against the mounting direction F is executable. If the locking element 12 is not in its locking position, the mobility of the stop element 14 is released. This is an important function for releasing a piston-cylinder unit 3 from the dispenser 1.
  • This release division of the first fastening device 16 (seventh state) is shown in FIG. 11, the longitudinal section through the locking element 12 being shown in FIG. 11.
  • the first fastening device 16 has two pivotally mounted Zylindergreifhebel 23 which can engage behind the mounting portion 9 of the cylinder 8 in the fixing position of the first fastening means 16.
  • the Zylindergreifhebel 23 are each carried out with two arms with a gripper arm 23a and an actuating arm 23b and pivotally mounted in the connecting region of the gripper arm 23a and actuating arm 23b.
  • Spring elements 24 load the Zylindergreifhebel 23 such that the gripping arms 23a are pivoted in the absence of a counter force radially inwardly, in particular towards each other.
  • the Zylindergreifhebel 23 are arranged and mounted so that the gripping arms 23 a when attaching a piston-cylinder unit 3 from the mounting portion 9 of Cylinders 8 can be pressed radially outward (first state as shown in Fig. 5) and then automatically engage behind the mounting portion 9, when the mounting portion 9 has been moved far enough in the mounting direction F.
  • This second state is shown in FIG.
  • the fixing position of the first fastening device 16 can be seen in FIGS. 6 to 14.
  • the gripper arms 23a are arranged here so that they are not visible in the illustrated vertical longitudinal sections.
  • the gripping arms 23a are curved in cross section, so that it acts in Fig. 5 when not shown cut upper gripping arm 23a, as if this upper gripper arm 23a is not pressed far enough radially outward.
  • an inner side of the respective gripping arm 23a extends along the outside of the fastening section 9, wherein the inside of the respective gripping arm 23a does not have to rest completely against the outside of the fastening section 9.
  • the actuating arms 23b of the cylinder gripper levers 23 of the first fastening device 16 each have a guide contour 25 into or on which a respective cam 26 of the locking element 12 is engaged can when the locking member 12 is moved in the attachment direction F in the release position.
  • the guide contours 25 are formed and arranged so that when moving the locking member 12 in the mounting direction F, the actuating arms 23b are moved by means of the cam 26 radially inwardly. Thereby, the gripping arms 23a are moved radially outward.
  • the dispenser 1 and its rear part 18 are designed so that by means of the rear part 18 attached to the dispenser 1 piston-cylinder unit 3 is separable from the dispenser 1, after the first fastening device 16 is moved from its fixing position into its release position and the piston-cylinder unit 3 has been released.
  • the dispenser 1 and its rear part device 18 are designed so that the spring element 19 can decompress in the release division of the fastening device 16 and a separation of the piston-cylinder unit 3 from the dispenser 1 is not hindered.
  • the dispenser 1 a second attachment means 27 which serves to fix the piston 7 on the dispenser 1.
  • the second fastening device 27 is movable into a fixing position, in which the piston 7 is releasably connected to the piston actuator 10 of the dispenser 1 such that the piston 7 for receiving and / or dispensing fluid volumes by means of the piston actuator 10 relative to the cylinder 8 between a retracted Position and an extended position is movable.
  • This fixing position of the second fastening device 27 is shown in FIGS. 9, 10, 12 and 13.
  • the second fastening device 27 has two pivotally mounted piston gripping levers 28, by means of which the piston 7 can be gripped when the second fastening device 27 is moved into its fixing position.
  • Each piston gripping lever 28 here has a cutting roller with five cutting elements integrally formed on the cutting roller, which engage in the fixing position on the piston 7 when moving the piston gripping lever 28 and partially penetrate into the piston 7.
  • the second attachment means 27 is movable by moving the locking member 12 in the axial direction A of the fixing position in a release pitch and vice versa, wherein the piston 7 is not connected to the piston actuator 10 in the release division of the second fastening device 27.
  • each piston gripping lever 28 has a control head 29 and the locking element 12 has a matching guide contour 30 and an axial extension 31.
  • the piston gripping levers 28 are pivotable.
  • Each actuator head 29 is guided on the guide contour 30 of the locking element 12 when moving the locking element 12 and / or the piston actuator 10.
  • both adjusting heads 29 are in the guide contour 30, in particular in each case in a separate section between two walls of the guide contour 30, guided.
  • both adjusting heads 29 rest on the axial extension 31 and the housing 2 and are further apart than in the fixing position. If the second fastening device 27 is in its release position (FIG. 8) and the locking element 12 is then moved counter to the attachment direction F from its basic position to a second intermediate position, the adjusting heads 29 are moved along the axial extension 31 and the housing 2 into the guide contour 30 guided, and that each actuator head 29 in a separate section of the guide contour 30. The control heads 29 are moved towards each other.
  • the piston gripping levers 28 are moved towards the pistons 7 until they engage or fix the pistons 7, in particular with their cutting rollers.
  • the second fastening device 27 is in its fixing position (FIG. 9).
  • the second attachment means 27 is movably coupled to the piston actuator 10 and in its fixation position throughout the way it can move the piston actuator 10 can be guided by the locking member 12 to remain in its locked position ,
  • the extent of the guide contour 30 in the axial direction A is greater than the piston actuator 10 executable stroke.
  • the adjusting heads 29 are guided along the guide contour 30 and ultimately out of it , so that the adjusting heads 29 are guided between the axial extension 31 and the housing 2.
  • the adjusting heads 29 are moved apart or removed from each other. As a result, the piston gripping levers 28 are moved away from the piston 7, so that the piston 7 is no longer fixed. Now is the second fastening device 27 in its release position.
  • the axial extension 31 fulfills a further object, namely, it limits the path of the locking element 12 when it is moved counter to the mounting direction F in its locking position, without a piston-cylinder unit is attached to the dispenser 1.
  • the stop element 14 due to the missing cylinder 8 has no counter-stop.
  • the axial extension 31 is designed and arranged so that when the locking element 12 strikes the stop element 14, it encounters a stop of the housing 2, whereby the locking element 12 and thus the stop element 14 can not be moved against the attachment direction F further.
  • the dispenser 1 has means for optically detecting the attachment of a piston-cylinder unit 3 to the dispenser 1.
  • These means comprise a light barrier 32 with a light beam source and a sensor for detecting light beams of the light beam source, wherein the light barrier 32 is arranged so that movement of the stop element 14 in the axial direction A of the light barrier 32 is detectable.
  • the stop element 14 has a web 33 which is moved synchronously with the stop element 14. If the stop element 14 is moved or pressed far enough in the attachment direction F, the web 33 interrupts the light barrier 32.
  • the dispenser 1 can determine whether a piston-cylinder unit 3 is attached to the dispenser 1 or not. This detection allows the triggering of further steps, eg. B. moving the locking element 12th
  • the piston actuator 10 for detecting a piston-side reference point on the piston 7 is movable until a stop 34 of the piston actuator 10 rests against an end face of the piston 7. This third state is shown in FIG.
  • the absolute position of this piston-side reference point can be detected by means for determining the position.
  • the dispenser 1 comprises a detection device for automatically identifying the type of a piston-cylinder unit 3 attached to the dispenser 1.
  • the detection device has a radial information reader, by means of which information of a radially oriented information carrier section 35 of the piston-cylinder unit 3 can be detected.
  • the detection device has an axial information reader, by means of which information of an axially aligned information carrier section 36 of the piston-cylinder unit 3 can be detected.
  • the radially oriented information carrier portion 35 is formed here as a radially aligned recess in the piston 7 and the axially aligned information carrier portion 36 as an axially aligned recess in an end face of the piston 7.
  • the axial information reader By moving the locking member 12 from its home position to the first intermediate position, at least a portion of the axial information reader is insertable into the axially aligned recess 36 in the axial direction A.
  • the axial information reader has a detection element 38, which is at least partially insertable into the axially aligned recess 36 in the axial direction A.
  • the depth of the axially aligned recess 36 can be determined. Based on the thus determined depth of the recess 36, the type of the piston-cylinder unit 3 can be at least partially identified.
  • the previously determined piston side reference point marks the starting point of a determination of the depth of the axially aligned recess 36.
  • the detection element 38 is elastically biased here by means of a spring 39 against the mounting direction F.
  • the locking element 12 moved from the first intermediate position to its basic position, that is Detection element 38 movable into a release position and preserved there.
  • the locking element 12 holds the detection element 38 in its release position by a driver 40 of the locking element 12 against an extension 41 of the detection element 38 counteracts the force of the spring 39 and blocks movement of the detection element 38 in the direction of the spring force (ie against the mounting direction F).
  • the axially aligned recess 36 is open here in the axial direction A upwards.
  • the recess 36 is formed here in the form of a groove. It is therefore not a hole which is enclosed in the radial direction R. Rather, the recess 36 in the radial direction R is partially open to the outside, and that along the entire depth of the recess 36th
  • the dispenser 1 has other facilities, u. a. an electronic control device, a transmission device, a power supply device, a display device and an input device.
  • the locking element 12 is in its home position.
  • the attachment portion 9 of the cylinder 8 of the piston-cylinder unit 3 to the stop element 14 of the dispenser 1 by means of a at least in Essentially applied in axial direction A running movement, typically manually by a user.
  • the piston 7 is moved through the passage 15 of the stop element 14.
  • the gripping arms 23a of the cylinder gripping levers 23 are pressed radially outwards by the attachment section 9, so that the gripper arms 23a slide along the attachment section 9. This first state is shown in FIG.
  • the piston actuator 10 has been moved to a release position prior to application.
  • the cylinder 8 After application, the cylinder 8 is moved relative to the housing 2 in the mounting direction F. As a result, the stop element 14 is pressed in the mounting direction F against the return force of the rear sub 18. In this case, the spring element 19 of the rear-part device 18 is compressed.
  • the movement of the stop element 14 in the attachment direction F is detected optically by means of the light barrier 32. Then, the piston actuator 10 is automatically moved against the mounting direction F on the piston 7 until the stop 34 of the piston actuator 10 rests against an end face of the piston 7.
  • This third state is shown in FIG. In this case, the path traveled by the piston actuator 10 is determined.
  • a piston-side reference point is detected, which is, so to speak, a path calibration which makes the method at least largely independent of differences in the dimensional tolerances of the parts of the piston-cylinder unit 3.
  • the locking element 12 is then automatically moved against the mounting direction F in the first intermediate position.
  • the locking element 12 is then automatically moved against the mounting direction F in the second intermediate position.
  • the second fastening device 27 is moved with its piston gripping levers 28 into its fixing position, in which the piston 7 is releasably connected to the piston actuator 10 such that the piston 7 is movable relative to the cylinder 8 for receiving and dispensing fluid volumes by means of the piston actuator 10.
  • This fifth state is shown in FIG.
  • the projection 37 of the radial information reader is inserted into the radially aligned recess 35.
  • the locking element 12 is then automatically moved against the mounting direction F, in its locking position.
  • This sixth state is shown in FIG.
  • the fixing portion 9 of the cylinder 8 is clamped between the Zylindergreifhebeln 23 and the stopper member 14, so that a relative movement between the cylinder 8 and the housing 2 in the axial direction A and in the radial direction R and is blocked in the circumferential direction.
  • a relative movement between the piston 7 and the cylinder 8 by means of the piston actuator 10 can take place for receiving or discharging a fluid volume.
  • the piston actuator 10 is moved so that the piston 7 is in its retracted position.
  • the locking element 12 in the mounting direction F from its locking position on the second Intermediate position and the first intermediate position moves into its basic position.
  • the second fastening device 27 is moved from its fixing position into its release position.
  • the piston 7 is no longer connected to the piston actuator 10.
  • the protrusion 37 of the radial information reader is moved out of the radially aligned recess 35 and the detection element 38 out of the axially aligned recess 36.
  • the locking element 12 is automatically moved in the attachment direction F further in the release position.
  • the first fastening device 16 is moved from its fixing position into its release position.
  • This seventh state is shown in FIG. 11. Now, a relative movement between the cylinder 8 and the housing 2 against the mounting direction F is freely executable.
  • the piston-cylinder unit 3 Due to the restoring force of the return device 18 on the stop element 14, in particular the decompression of the spring element 19, the piston-cylinder unit 3 is separated from the dispenser 1.
  • the movement of the stop element 14 initiated by the spring element 19 in the axial direction A is detected by the light barrier 32.
  • the locking element 12 is automatically moved to its home position and the piston actuator 10 in its basic position, so that the described sequence with the attachment of a piston-cylinder unit 3 can start again.

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  • Health & Medical Sciences (AREA)
  • Clinical Laboratory Science (AREA)
  • Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Coating Apparatus (AREA)

Abstract

La présente invention concerne un distributeur pour aspirer et expulser des volumes de fluide, sur lequel un ensemble piston-cylindre (3) comprenant un piston (7) et un cylindre (8) peut être fixé de manière détachable par un mouvement effectué au moins sensiblement dans la direction axiale (A) du distributeur (1). Le distributeur (1) comporte un actionneur de piston (10) servant à déplacer le piston (7) relativement au cylindre (8). L'actionneur de piston (10) est monté mobile dans le distributeur (1) et entraîné par un dispositif d'entraînement (11). Selon l'invention, le distributeur (1) comporte un élément de verrouillage (12) monté mobile dans le distributeur (1) et entraîné par un dispositif d'entraînement (13) additionnel. L'invention concerne en outre un système d'aspiration et d'expulsion de volumes de fluide, un procédé pour fixer de manière détachable un ensemble piston-cylindre sur un distributeur et un procédé pour détacher un ensemble piston-cylindre fixé sur un distributeur.
EP18706712.9A 2017-02-23 2018-02-20 Fixation et séparation d'un ensemble piston-cylindre sur/d'un dispositif servant à aspirer et à expulser des volumes de fluide Active EP3554707B1 (fr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE202017101009.0U DE202017101009U1 (de) 2017-02-23 2017-02-23 Anbringen und Lösen einer Kolben-Zylinder-Einheit an bzw. von einem Dispenser zum Aufnehmen und Abgeben von Fluidvolumina
PCT/EP2018/054080 WO2018153830A1 (fr) 2017-02-23 2018-02-20 Fixation et séparation d'un ensemble piston-cylindre sur/d'un dispositif servant à aspirer et à expulser des volumes de fluide

Publications (2)

Publication Number Publication Date
EP3554707A1 true EP3554707A1 (fr) 2019-10-23
EP3554707B1 EP3554707B1 (fr) 2021-05-12

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EP18706712.9A Active EP3554707B1 (fr) 2017-02-23 2018-02-20 Fixation et séparation d'un ensemble piston-cylindre sur/d'un dispositif servant à aspirer et à expulser des volumes de fluide

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US (1) US11547992B2 (fr)
EP (1) EP3554707B1 (fr)
CN (1) CN110337332B (fr)
DE (1) DE202017101009U1 (fr)
WO (1) WO2018153830A1 (fr)

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US11446672B2 (en) 2019-10-25 2022-09-20 Mettler-Toledo Rainin, LLC Powered positive displacement pipette syringe piston grasping mechanism
US11389792B2 (en) * 2019-10-25 2022-07-19 Mettler-Toledo Rainin, LLC Syringe for powered positive displacement pipette
US11911767B2 (en) 2019-10-25 2024-02-27 Mettler-Toledo Rainin, LLC Positive displacement pipette syringe identification system
US11471878B2 (en) 2019-10-25 2022-10-18 Mettler-Toledo Rainin, LLC Powered positive displacement pipette

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Publication number Publication date
US20200171481A1 (en) 2020-06-04
CN110337332A (zh) 2019-10-15
WO2018153830A1 (fr) 2018-08-30
US11547992B2 (en) 2023-01-10
DE202017101009U1 (de) 2018-05-24
CN110337332B (zh) 2022-03-25
EP3554707B1 (fr) 2021-05-12

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