Classifications

• • A—HUMAN NECESSITIES
  • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
  • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
  • A61K31/00—Medicinal preparations containing organic active ingredients
  • A61K31/12—Ketones
  • A61K31/121—Ketones acyclic
• • A—HUMAN NECESSITIES
  • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
  • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
  • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
  • A61P7/04—Antihaemorrhagics; Procoagulants; Haemostatic agents; Antifibrinolytic agents
• • A—HUMAN NECESSITIES
  • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
  • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
  • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
  • A61K36/18—Magnoliophyta (angiosperms)
  • A61K36/185—Magnoliopsida (dicotyledons)

Definitions

• Haemorrhoids are commonly called haemorrhoids only when they cause haemorrhoidal ailments. They however remain unnoticed until they are of normal size and are able to perform their precise rectal closure function (F. H. Wullink, Hemoroidy. Poradnik dla pacjentow, 1st Polish edition, ed. K. Matysiak, Wroclaw 2008, pages 10-11.)
• DC electrotherapy requires time-consuming (up to 14 minutes) DC applications. Time and intensity increase with the progression of piles. Repeated applications to the same place are recorded in 30% of patients.
• Infrared photocoagulation focuses the infrared radiation from the halogen lamp through the polymer probe at its top.
• the 0.5-2 second energy pulses are delivered to the base of the vascular bundle, which penetrate about 2.5 mm into the tissue.
• the most effective method is rubber bands, and patients undergoing this procedure are least often treated for haemorrhoids. Unfortunately, this group of patients simultaneously reported most often pain after surgery. In conclusion it might be admitted that non-surgical methods may be considered as the initial procedures of choice in patients with grade I and II haemorrhoids and early, small piles in grade III.
• composition of the invention is preferably in the form of a semi-solid such as an ointment or a cream, preferably comprising a petrolatum as a physiologically acceptable excipient.
• the composition comprises xanthohumol in an amount ranging from 0.001% by weight to 5.0% by weight of xanthohumol in terms of the total weight of the composition, more preferably, the composition comprises xanthohumol in an amount ranging from 0.01% by weight to 1.0% by weight of xanthohumol in terms of the total weight of the composition, most preferably, the composition comprises xanthohumol in an amount ranging from 0.1 % by weight to 0.5% by weight of xanthohumol in terms of the total weight of the composition.
• Xanthohumol also forms complexes with metals, especially with transition metals such as copper or zinc. Such xanthohumol complexes may also be used according to the invention.
• compositions may also contain one or more buffers, stabilizing agents, surfactants, wetting agents, lubricating agents, emulsifiers, suspending agents, preservatives, antioxidants, matting agents, lubricants, processing aids, dyes, sweeteners, perfumes, flavours and other known additives providing an elegant presentation of the drug or helping in the manufacture of a pharmaceutical or cosmetic or care product (i.e. a drug, a medicinal preparation, a medical product, a cosmetic product).
• a pharmaceutical or cosmetic or care product i.e. a drug, a medicinal preparation, a medical product, a cosmetic product.
• composition of the invention may be advantageously administered as an ointment or suppositories, however, other pharmaceutical or cosmetic forms such as a cream, gel or spray or dusting powder, powder or wet wipe may also be convenient for the patient or the recipient of the product.
• xanthohumol is effective and causes a gradual reversion of the symptoms of the haemorrhoidal disease to its complete disappearance even in the advanced grade of the haemorrhoidal disease.
• xanthohumol has a regenerating, nourishing, antipruritic and care effect on the skin around the anus, eliminating burning sensation and soreness, resulting in a noticeable improvement and alleviation, especially in the case of irritation of the anus and and the anal area.
• Embodiment 5 Use of xanthohumol in the anal area for the skin care purposes

Landscapes

• Health & Medical Sciences (AREA)
• Veterinary Medicine (AREA)
• Chemical & Material Sciences (AREA)
• Medicinal Chemistry (AREA)
• Pharmacology & Pharmacy (AREA)
• Life Sciences & Earth Sciences (AREA)
• Animal Behavior & Ethology (AREA)
• General Health & Medical Sciences (AREA)
• Public Health (AREA)
• Engineering & Computer Science (AREA)
• Epidemiology (AREA)
• Bioinformatics & Cheminformatics (AREA)
• Diabetes (AREA)
• Hematology (AREA)
• Chemical Kinetics & Catalysis (AREA)
• General Chemical & Material Sciences (AREA)
• Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
• Organic Chemistry (AREA)
• Medicinal Preparation (AREA)
• Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Applications Claiming Priority (2)

Publications (1)

Family

ID=59684565

Family Applications (1)

Country Status (3)

Families Citing this family (1)

Family Cites Families (2)

• 2016
  • 2016-10-12 PL PL419082A patent/PL235226B1/pl unknown
• 2017
  • 2017-10-12 EP EP17804652.0A patent/EP3525777A1/en not_active Withdrawn
  • 2017-10-12 WO PCT/IB2017/056302 patent/WO2018069855A1/en unknown

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