EP3452001B1 - Vorrichtung und verfahren zum verpacken von festen arzneimitteln, vorrichtung zum lagern und ausgeben solcher arzneimittel sowie abgabeverfahren - Google Patents

Vorrichtung und verfahren zum verpacken von festen arzneimitteln, vorrichtung zum lagern und ausgeben solcher arzneimittel sowie abgabeverfahren Download PDF

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Publication number
EP3452001B1
EP3452001B1 EP17725323.4A EP17725323A EP3452001B1 EP 3452001 B1 EP3452001 B1 EP 3452001B1 EP 17725323 A EP17725323 A EP 17725323A EP 3452001 B1 EP3452001 B1 EP 3452001B1
Authority
EP
European Patent Office
Prior art keywords
medicaments
unit dose
dish
storage
drugs
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Active
Application number
EP17725323.4A
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English (en)
French (fr)
Other versions
EP3452001A1 (de
Inventor
Grégory FOUBET
Michel FOUBET
Olivier FOUBET
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Distraimed SARL
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Distraimed SARL
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Publication date
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Publication of EP3452001A1 publication Critical patent/EP3452001A1/de
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Publication of EP3452001B1 publication Critical patent/EP3452001B1/de
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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61J—CONTAINERS SPECIALLY ADAPTED FOR MEDICAL OR PHARMACEUTICAL PURPOSES; DEVICES OR METHODS SPECIALLY ADAPTED FOR BRINGING PHARMACEUTICAL PRODUCTS INTO PARTICULAR PHYSICAL OR ADMINISTERING FORMS; DEVICES FOR ADMINISTERING FOOD OR MEDICINES ORALLY; BABY COMFORTERS; DEVICES FOR RECEIVING SPITTLE
    • A61J7/00—Devices for administering medicines orally, e.g. spoons; Pill counting devices; Arrangements for time indication or reminder for taking medicine
    • A61J7/0069—Trays for holding or distributing medicines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61J—CONTAINERS SPECIALLY ADAPTED FOR MEDICAL OR PHARMACEUTICAL PURPOSES; DEVICES OR METHODS SPECIALLY ADAPTED FOR BRINGING PHARMACEUTICAL PRODUCTS INTO PARTICULAR PHYSICAL OR ADMINISTERING FORMS; DEVICES FOR ADMINISTERING FOOD OR MEDICINES ORALLY; BABY COMFORTERS; DEVICES FOR RECEIVING SPITTLE
    • A61J1/00—Containers specially adapted for medical or pharmaceutical purposes
    • A61J1/03—Containers specially adapted for medical or pharmaceutical purposes for pills or tablets
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B65—CONVEYING; PACKING; STORING; HANDLING THIN OR FILAMENTARY MATERIAL
    • B65D—CONTAINERS FOR STORAGE OR TRANSPORT OF ARTICLES OR MATERIALS, e.g. BAGS, BARRELS, BOTTLES, BOXES, CANS, CARTONS, CRATES, DRUMS, JARS, TANKS, HOPPERS, FORWARDING CONTAINERS; ACCESSORIES, CLOSURES, OR FITTINGS THEREFOR; PACKAGING ELEMENTS; PACKAGES
    • B65D25/00—Details of other kinds or types of rigid or semi-rigid containers
    • B65D25/02—Internal fittings
    • B65D25/04—Partitions
    • B65D25/08—Partitions with provisions for removing or destroying, e.g. to facilitate mixing of contents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61J—CONTAINERS SPECIALLY ADAPTED FOR MEDICAL OR PHARMACEUTICAL PURPOSES; DEVICES OR METHODS SPECIALLY ADAPTED FOR BRINGING PHARMACEUTICAL PRODUCTS INTO PARTICULAR PHYSICAL OR ADMINISTERING FORMS; DEVICES FOR ADMINISTERING FOOD OR MEDICINES ORALLY; BABY COMFORTERS; DEVICES FOR RECEIVING SPITTLE
    • A61J7/00—Devices for administering medicines orally, e.g. spoons; Pill counting devices; Arrangements for time indication or reminder for taking medicine
    • A61J7/0007—Pill breaking or crushing devices
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61J—CONTAINERS SPECIALLY ADAPTED FOR MEDICAL OR PHARMACEUTICAL PURPOSES; DEVICES OR METHODS SPECIALLY ADAPTED FOR BRINGING PHARMACEUTICAL PRODUCTS INTO PARTICULAR PHYSICAL OR ADMINISTERING FORMS; DEVICES FOR ADMINISTERING FOOD OR MEDICINES ORALLY; BABY COMFORTERS; DEVICES FOR RECEIVING SPITTLE
    • A61J7/00—Devices for administering medicines orally, e.g. spoons; Pill counting devices; Arrangements for time indication or reminder for taking medicine
    • A61J7/0076—Medicament distribution means

Definitions

  • the invention relates to a device and a method for packaging at least one unit dose of medicinal products in divided solid dosage form - in particular not entirely powdered, preferably not powdered - such as for example tablets, cachets, capsules, capsules, pills, lozenges, dragees ... to a patient.
  • the invention also relates to a device for storing and dispensing at least one unit dose of such drugs and a method for dispensing at least one unit dose of such drugs with a view to its administration to a patient.
  • FR 2 913 333 a weekly pill box allowing the storage and delivery of solid drugs to a patient, the pill box having 28 thermoformed drug storage cells in a PVC support, each cell of the pill box being compartmentalized, sized to receive a unit dose of drug (s) and detachable from the weekly pill organizer.
  • Each cell of the weekly pill organizer is sealed with a sealing label applied and glued to the PVC backing.
  • Each sealing label is adapted to be able to be torn and allow the taking of the drugs contained in a cell.
  • the cells of such a weekly pill organizer are distributed in four columns of seven cells, each column of cells corresponding to one of four daily unit doses, each row corresponding to the four unit doses on the same day of the week.
  • Each cell of such a weekly pill organizer has a plurality of compartments formed by the PVC support, each compartment being separated from adjacent compartments by a wall formed by the PVC support forming the pill organizer.
  • Such a weekly pill organizer allows storage of a plurality of medicaments separated from one another and makes it possible to prevent distinct medicaments, comprising distinct active ingredients, being able to come into contact in a cell of the weekly pill organizer during their storage.
  • such a pill dispenser has drawbacks. On the one hand, it allows the patient, the different drugs being separated from each other, to make a selection of the different individualized drugs when the cell is open, consisting of keeping certain drugs and rejecting other drugs when taking. unit drug. Such selection may allow the patient to escape the intake of a particular drug. Such rejection is likely to lead to harmful consequences for the patient: at best, the treatment loses its therapeutic effectiveness, at worst, the absence of taking this drug leads to the development of side effects harmful to the patient.
  • such a weekly pill organizer requires transferring the drugs contained in a cell into an annex receptacle separate from the pillbox for the purpose of taking the drugs.
  • a pill dispenser does not make it possible to manually remove the drugs one by one from each compartment of the cell because of the discomfort caused by the wall separating two adjacent compartments.
  • the invention therefore aims to overcome these drawbacks.
  • the weekly pill organizer of FR 2 913 333 does not make it possible to make such a mixture available to the patient without requiring a transfer of the medicaments from the unit dose to an annex container separate from the pillbox to facilitate the ingestion of the unit dose of medicaments.
  • the invention therefore relates to a device and a packaging method, a storage and distribution device and a method for dispensing at least one unit dose of medicinal products in divided solid dosage form - in particular not entirely powdered, preferably non-powdered. - such as, for example, tablets, cachets, capsules, capsules, pills, lozenges, dragees, etc., making it possible to limit - in particular to completely eliminate - the risk of selection of drugs by the patient during taking medication.
  • the invention therefore relates to such a storage and distribution device and a method for distributing at least one unit dose of such drugs which are secure.
  • the invention relates to a device and a packaging method, a storage and distribution device and a distribution method of at least one unit dose of such drugs which at the same time allow a storage of drugs separated from one another. others, limiting the risks of interactions between different drugs during storage, but also a secure distribution of drugs, that is to say limiting the risks of drug selection by the patient.
  • the invention relates in particular to such a device for the storage and distribution of at least one unit dose of such drugs, the use of which by a patient is facilitated.
  • the invention relates in particular to such a device for the storage and distribution of at least one unit dose of such medicinal products which does not require the use of an annex container such as a cup separate from the pillbox for the distribution to the patient of single drug intake.
  • Certain aspects of the invention also aim in combination to provide a device and a packaging method, a storage and distribution device and a method of dispensing at least one unit dose of such medicaments allowing provision to the patient.
  • a unit dose of solid medicament in the divided state with a view to its mixing with a flowable food composition-in particular a compote or a jam-, so that the patient can ingest the mixture without difficulty.
  • unit dose of medicaments usually designates a set of medicaments which are intended to be administered substantially in a single dose to a patient at a given time, said set of medicaments being in accordance with the dosage.
  • a medical prescription intended for the treatment of at least one pathology affecting this patient. It may be a set of distinct medicaments formed of medicaments of distinct galenical forms and / or comprising distinct active substances and / or dosages of distinct active substances.
  • a unit dose of medicaments can also comprise a plurality of identical medicaments, that is to say comprise a plurality of medicaments comprising the same active substance (s), with the same dosage of the active substance (s) and in the same galenic form (s).
  • any divided solid dosage form which is slightly pulverulent or non-pulverulent can be stored in a device according to the invention and dispensed from this device.
  • the non-pulverulent solid dosage form can be chosen from the group consisting of tablets, cachets, gelatin capsules, capsules, pills, lozenges, dragees, etc.
  • a device for storing and distributing at least one unitary dose of medicaments according to the invention in which at least one partition is removable when opening at least one storage and distribution cell.
  • such drugs in fact allows secure storage of at least one unit dose of drugs before opening at least one cell containing this unit dose of drugs, the different drugs of the unit dose of drugs being separated when the cell of storage and corresponding distribution is closed. It therefore allows storage of the different drugs of a unit dose of drugs in a state separated from each other avoiding any contact between them. different medicines and avoiding interference between these medicines when they are stored. It also allows grouping and facilitated distribution of drugs from the unit intake of drugs mixed in the cuvette when the storage cell is open and the removable partition is removed from the cuvette. They also observed that a device and a packaging method according to the invention make it possible to form a device for the storage and distribution of at least one unit dose of drugs.
  • the packaging device is drug-free and comprises at least one bowl, at least one cover and at least one removable partition in the dissociated state (in the form of a “kit”), the (the) bowl (s), the cover (s) and the removable partition (s) being separated from each other and adapted to be able to form -after assembly with the unit dose of drugs- at least one cell for storing and distributing at least one unit dose of drugs, at least one such cell containing a unit dose of drugs.
  • the packaging device is in the partially assembled state, that is to say in a state in which the removable partition (s) is (are) arranged in the storage volume (s), forming storage compartments with the bowl (s), the cover (s) not blocking the opening of the ) bowl (s).
  • a packaging device is used during a process for preparing a device for storing and distributing at least one unit dose of medicaments. It is used during a step of distributing at least one unit dose of medicaments in compartments of a packaging device according to the invention prior to the fitting of the cover.
  • the cuvette (s) and the removable partition (s) are arranged to receive medicaments before the installation of the device. Cover (s), plugging of the cuvette (s) and formation of the cell (s).
  • the bowl has a peripheral shoulder delimiting an opening in the bowl, the cover being formed of a sealing film suitable for being able to adhere to the bowl. peripheral shoulder of the bowl.
  • At least one cuvette - in particular each cuvette - has a peripheral shoulder delimiting an opening of the cuvette - in particular of each cuvette -, at least one cover - in particular each cover - being formed of a sealing film adapted to be able to adhere on the peripheral shoulder of the cuvette - in particular of each cuvette-.
  • the peripheral shoulder of each cuvette forms a surface - in particular a substantially flat surface - for receiving and adhering the sealing film to the cuvette, the cuvette containing a removable partition and a unitary intake of drugs, the adhesion of the film closure on the peripheral shoulder of the cuvette allowing the cuvette to be blocked and the formation of a storage and distribution cell for at least one unit dose of drugs.
  • the sealing film has a main face, called the adhesive face, having at least one adhesive zone arranged so as to be able to adhere to the peripheral shoulder of the bowl.
  • said adhesive face of the sealing film is coated with an adhesive material.
  • the sealing film is formed from an adhesive material.
  • the sealing film is formed of an adhesive cellulosic material, in particular adhesive paper.
  • the sealing film comprises a removable protective film for the adhesive material, the removable protective film being removable over at least part of the surface of the sealing film. Any type of adhesive material can be used, as long as the removable film is compatible with contact with drugs.
  • the sealing film has a subsequent opening precut of the cell by tearing of the film. shutter.
  • a pre-cut allows, on the one hand, the subsequent opening of the cell containing the unit dose of medicinal products and, on the other hand, the extraction of the removable partition.
  • the sealing film is formed from an essentially cellulosic material - in particular paper - of which said adhesive face is self-adhesive and coated with a removable protective film.
  • said adhesive face has a peripheral adhesive zone covered with a removable protective silicone film and is adapted to be able to be glued to the peripheral shoulder of the bowl when the silicone film is removed. , and a central area, preferably non-adhesive intended to extend opposite the storage space / volume, the storage space / volume containing the removable partition and the unitary medication intake.
  • the sealing film has a second main face, called the printed face, opposite to said adhesive face and having at least one inscription.
  • said printed face has at least one inscription aiming to identify the patient, to identify the medication (s), to identify the date of the medication (s) and / or to identify the time of medication. drug (s).
  • Registration can take any form that can be identified by the patient, by the prescriber, by nursing staff or by means of an identifier reader. This may be, for example, writing characters, a color code, a bar code or a QR code. It may be, for patients visually impaired, with inscriptions in braille writing.
  • Said printed side has inscriptions relating to the patient and / or to the medical prescription.
  • the cup has a depth extending perpendicularly to the main direction of elongation, perpendicular to the width and of a value less than the width, in particular between 10 mm and 20 mm.
  • each bowl has a depth extending perpendicular to the main direction of elongation, perpendicular to the width and of a value less than the width - in particular between 10 mm and 20 mm - .
  • the depth is of a value greater than the width.
  • each cuvette of the packaging device may be identical. However, nothing prevents providing that at least two cups of the packaging device have dimensions and to adapt the dimensions of each sealing film and the dimensions of each removable partition to the dimensions of each cuvette.
  • each cuvette is formed from a material chosen from the group formed by thermoplastic materials and thermosetting materials.
  • the thermoplastic material can be chosen from the group formed by polystyrene (PS), polyethylene (PE), poly (ethylene terephthalate) (PET), low density polyethylene (LDPE), polypropylene (PP), polycarbonate (PC), acrylonitrile butadiene styrene (ABS), polyvinyl chloride (PVC), polymethyl methacrylate (PMMA), impact polystyrene (SB) and mixtures thereof.
  • PS polystyrene
  • PE polyethylene
  • PET poly (ethylene terephthalate)
  • LDPE low density polyethylene
  • PP polypropylene
  • PC polycarbonate
  • ABS acrylonitrile butadiene styrene
  • PVC polyvinyl chloride
  • PMMA polymethyl methacrylate
  • SB impact polystyrene
  • each cuvette is formed from a transparent material.
  • each removable partition is formed of a material chosen from the group formed of thermoplastic materials and thermosetting materials.
  • the material of the bowl may be identical or different from the material of the partition.
  • the packaging device is adapted to be able to receive medicaments and to form a plurality of cells for storing and distributing a plurality of unit intakes of such medicaments, the cells of the plurality of storage and distribution cells being linked together in the form of a tray of drug storage and distribution cells.
  • each cell of the plurality of drug storage and distribution cells is linked to adjacent cells by breakable bonds having precuts for facilitated separation of each cell and adjacent cells.
  • Each cell of the drug storage and distribution device formed from the packaging device is therefore detachable from the drug storage and distribution device and adjacent cells.
  • the packaging device is adapted to be able to form a pill organizer. weekly, the number of cells forming the storage tray being chosen to allow one, two, three or four unit dose (s) of drugs per day for seven days of weekly treatment.
  • a packaging device according to the invention advantageously comprises 28 storage and distribution cells for 28 unit doses of drugs.
  • the packaging device is free from drugs.
  • the packaging device is in an at least partially dissociated state (in the form of a "kit"), the plurality of cuvettes, the plurality of lids and the plurality of removable partitions not forming a plurality of storage cells of one. plurality of unit doses of drugs.
  • the sealing sheet comprises a plurality of sealing films, the sealing sheet and the sealing films being sized so that each film of the plurality of films forming the sheet can seal the opening a cuvette of the packaging device.
  • the sealing sheet has pre-cuts arranged to allow separation of a sealing film.
  • the blanking sheet pre-cuts extend in correspondence with pre-cuts in the plurality of storage cuvettes on the receiving tray and allow the separation of one cell from the plurality of cells for dispensing a single intake of. medication to a patient.
  • the packaging device comprises a plurality of removable partitions linked to each other in the form of a partition plate and so that each partition of the plurality of removable partitions can cooperate with one cuvette of the plurality of cuvettes of the drug receiving and storage tray and forming in each cuvette a plurality of compartments.
  • each partition of the plurality of removable partitions is linked to the adjacent removable partitions by means of a connection having a precut.
  • each cuvette of the plurality of cuvettes of the drug receiving tray has a peripheral gluing shoulder with a sealing film bordering the opening of the cuvette.
  • each cuvette having a peripheral gluing shoulder of a sealing film bordering the opening of the cuvette, the peripheral gluing shoulders of the plurality of cuvettes are substantially coplanar. The plurality of coplanar peripheral shoulders allow application of the sealing sheet of the plurality of cuvettes to close the storage space / volume of each cuvette in the plurality of cuvettes and to form a device for storing and dispensing at least one unit dose of such drugs.
  • the plurality of cuvettes of the storage tray for the unitary intake of such drugs is a drug receptacle in which each cuvette of the receptacle is linked to the adjacent cuvettes by means of connections having pre-cutouts for easy separation of the cell and the adjacent cells.
  • the sealing sheet of the plurality of cuvettes also has pre-cutouts for separating each sealing film and each cell of the drug receiving tray, the pre-cuts of the sealing sheet being complementary to the pre-cuts of the medication tray. reception.
  • each sealing film of the sealing sheet also has opening cutouts for each corresponding cell by tearing of the sealing film.
  • the medication receiving tray is formed from a material chosen from the group formed of thermoplastic materials and thermosetting materials. It is possible to obtain the drug storage tray by thermoforming a thermoplastic material, forming in one step the plurality of cuvettes and the pre-cuts.
  • the tray is pre-cut so as to allow the separation of the cuvettes from each other manually (by tearing the pre-cuts).
  • the sheet is pre-cut so as to allow separation of the sealing films from each other manually (by tearing the pre-cuts). All of the removable partitions are precut so as to allow the removable partitions to be separated from each other manually (by tearing the precut).
  • different pre-cuts are adapted to allow separation of the cuvette, the sealing film and the removable partition of the same cell manually simultaneously (by simultaneous tearing of the different pre-cuts) in a single gesture. It is thus possible to separate a cell from a storage and distribution device according to the invention obtained with such a packaging device, this cell containing a unit dose of such drugs, in order to distribute it to the patient.
  • each removable partition has a plurality of partitions for separating drugs and forms, in cooperation with the bottom of the cuvette, a plurality of compartments for storing drugs in the cuvette in which it is positioned.
  • each - removable partition is a bottomless partition.
  • a removable partition is configured to allow a lateral separation of drugs from a unitary intake of drugs in the cuvette when the removable partition extends into the storage volume of the cuvette and defines therein in cooperation with the cuvette a plurality of compartments. making it possible to keep drugs in the single dose separate from each other.
  • Such a removable partition is also configured to allow release of medicaments in a form not separated from each other in the cuvette by simply extracting the removable partition from the cuvette.
  • Such a removable partition has, between two adjacent partitions, a lumen for maintaining drugs from the unitary intake of drugs in contact with the bottom of the bowl.
  • Such a removable partition is suitable so that the medicaments of the unitary medicament intake remain in a form not separated from each other in the bowl after extraction of the removable bulkhead.
  • the removable partition has between 2 and 10 partitions and forms in the bowl between 3 and 11 compartments.
  • the removable partition has 6 partitions and forms 7 medicine storage compartments in the bowl.
  • the removable partition can form in the bowl more than 7 medicine storage compartments.
  • the partitions of the removable partition may be of any suitable shape to allow the storage of a plurality of medicaments in the separate state.
  • the partitions of the removable partition are dimensioned to be able to form in cooperation with the bottom of the cuvette, a plurality of compartments for storing medicaments in a form separated from each other when the removable partition is positioned in the cuvette.
  • the partitions of the removable partition are sized to be able to extend substantially in contact with the bottom of the cuvette, but not integral with the bottom of the cuvette and so as to provide the lumen for maintaining the drugs in contact with the bottom of the cuvette, in particularly when storing medicines separated from each other and when extracting the removable partition.
  • the removable partition does not in itself constitute a medicine storage compartment or a medicine storage basin.
  • the removable partition is a bottomless partition comprising transverse partitions (that is to say adapted to extend transversely in the bowl) providing a light between two adjacent partitions, this light allowing the passage of drugs.
  • the partitions of the removable partition can be equidistant and form compartments of the same size in the bowl.
  • the partitions of the removable partition it is also possible for the partitions of the removable partition to form compartments of different sizes in the bowl.
  • Such a device makes it possible to store and distribute at least one unit dose of drugs having drugs of different sizes.
  • at least two compartments have different sizes.
  • the partitions can have any shape since they allow the formation of compartments in the bowl, the bottom of each compartment being formed by the bottom of the bowl.
  • Each partition may have two opposite main faces that are substantially parallel. It may also have two opposite main faces that are not parallel so that the compartments formed in the bowl are flared upwards, that is to say towards the face of the partition intended to receive the cover.
  • Such upwardly flared compartments allow easy filling of the bowl.
  • Such compartments flared downwards make it possible to facilitate the spreading of the medicaments at the bottom of the bowl.
  • the cuvette has a bottom, said storage bottom, and a side wall, said storage bottom and the side wall delimiting the storage volume of the unit dose of medication.
  • said storage bottom is substantially flat.
  • a bottom part of the bowl forms a recess for collecting the drugs from the unitary drug intake adapted to be able to receive the drugs and contain them, and to allow their crushing - in particular their grinding in the recess.
  • the bottom of the bowl is formed from said storage bottom and the recess and extends continuously between said storage bottom and the recess.
  • the recess allows a grouping of the drugs of the unitary intake of drugs in the recess after extraction from the removable partition, the crushing - in particular the grinding - of the drugs and the formation of a unitary intake. of medicament in the form of powder held in the recess.
  • the recess is dimensioned to be able to contain the drugs of the single drug intake. It is also sized in order to be able to receive a device for crushing medicaments in the recess and to allow the crushing - in particular the grinding - of medicaments in the recess.
  • the recess has a side wall, called the wall of the recess, of substantially symmetrical shape of revolution - in particular cylindrical of revolution -.
  • said wall of the recess may be of frustoconical shape.
  • the recess has a bottom of the recess. The bottom of the recess may be flat.
  • It can also be of substantially rounded shape and adapted to allow crushing of medicaments, in particular by means of a crushing and / or grinding member such as a pestle.
  • the bottom of the recess may be smooth. It may also have asperities sized to be able to cooperate with a crushing member - in particular a pestle - and to allow crushing - in particular grinding - of drugs.
  • the material forming the recess, its shape, the thickness of the bottom of the recess and of said wall of the recess, the roughness forming the bottom of the recess are chosen to allow efficient crushing - in particular grinding - of the drugs and to receive a flowing feed. and its mixture with the crushed drugs.
  • the crushed drugs are in the form of a solid in the divided state of small particle size, especially in the form of a powder.
  • the recess is a deformable recess between a retracted form in which the recess does not allow the crushing of the drugs and a deployed form in which the recess has a depth suitable for receiving the drugs and allowing their crushing.
  • a deformable recess may be a retractable / deployable recess along an axis perpendicular to said storage bottom of the bowl.
  • Such a deformable recess makes it possible to limit the size of the packaging device when the deformable recess is in the retracted position.
  • Such a deformable recess may have a side wall forming successive transverse folds arranged to allow a deformation called accordion deformation.
  • Said storage bottom and the recess allow, after opening the cell and extraction of the removable partition of the storage cuvette, collection of drugs from a unit dose of drugs in the recess by simply sliding the drugs between said storage bottom and the recess in which the medicaments are held for crushing or grinding, mixing in the recess with a flowing food and making them easier for the patient to take.
  • the recess and said storage bottom together form the bottom of the cuvette so that the medicaments of the unit dose of medicaments can be entrained, after extraction of the removable partition, from said storage bottom towards the recess by sliding on the storage bottom by a simple inclination of the bowl allowing the drugs to slide between said storage bottom and the reinforcement.
  • the recess forms a mortar for crushing - in particular for grinding - the medicaments of the unit dose of medicaments.
  • the recess and said storage bottom being formed of the same material, the recess and said storage bottom having different thicknesses, the thickness of the material forming the recess being greater than the thickness. thickness of the material forming said storage bottom. However, nothing prevents the material forming said storage bottom of the bowl and the material forming the recess from having the same thickness.
  • the recess has a flexural rigidity greater than the flexural rigidity of said storage bottom.
  • the recess has a flexural rigidity substantially equal to the flexural rigidity of said storage bottom.
  • the cup is formed by thermoforming of a thermoplastic material or of a thermosetting material.
  • the invention also extends to a method of packaging at least one unit dose of medicaments in divided solid dosage form, in which a packaging device according to the invention is used to obtain a storage and distribution device. at least one unit dose of medicaments according to the invention, ready for use.
  • the invention therefore extends to such a method of manufacturing a device for storing and distributing at least one unit dose of such drugs in which a packaging device according to the invention is used.
  • Such a distribution of medicaments is carried out by any suitable means. It can be a manual distribution carried out by an operator. It can also be an automated dispensing carried out by an automatic device according to the medical prescription. It can also be a semi-automated distribution in which an operator is assisted by an automatic device for the detection and validation of the distribution of the drugs.
  • variable inscriptions are printed on the cover - in particular at least one personal datum relating to the patient to be treated and / or at least one datum relating to a medical prescription.
  • the cover being a sealing film, to print at least one personal data relating to the patient to be treated and / or at least one data relating to the medical prescription before the application of the sealing film on the cuvette.
  • Such printing is for example carried out by means of a printer.
  • the cover being a sealing film having a main face, called the adhesive face, having at least one adhesive zone arranged to be able to adhere to the peripheral shoulder of a bowl, said adhesive face being protected by a removable protective film, the removable protective film is removed and the sealing film is applied to the bowl (s) comprising the removable partition (s) and at least one unit dose of drugs.
  • the invention also extends to a storage device and distribution of at least one unit dose of medicaments in divided solid galenic form - in particular not entirely pulverulent, preferably not pulverulent - obtained by a packaging process according to the invention.
  • the invention also extends to a device for storing and distributing at least one unit dose of medicaments obtained from a packaging device according to the invention.
  • the removable partition is adapted to be able to be extracted from the cuvette, the drugs then no longer being separated from each other in the cuvette after extraction of the removable partition.
  • the removable partition is integral with the cover so as to allow, when the storage cell is opened, simultaneous extraction of the removable partition from the bowl and a random distribution. drugs in the bowl.
  • the operation of dispensing a unit dose of medication is simplified and makes it possible to form in the bowl, in a single step, a unit dose of medication, the withdrawal of which by the patient is facilitated and without having to use an annex container.
  • the removable partition extends into the bowl without connection with the cover so that the opening of the bowl allows extraction of the removable partition from the bowl afterwards. opening of the cuvette and subsequent mixing of the drugs in the cuvette.
  • the removable partition is separated from the cover so that the opening of the storage cell requires deferred extraction (that is to say after removal of the cover) removable partition outside the cuvette to form a random distribution of drugs in the cuvette.
  • the removable partition advantageously has gripping means adapted to facilitate the extraction of the removable partition after opening of the cell.
  • the removable partition has a tab for gripping and extracting the removable partition.
  • a bottom part of the bowl forms a recess for collecting the drugs of the unit dose of drugs. adapted to be able to receive the drugs and contain them, and to allow their crushing - in particular their grinding - in the recess.
  • the drugs of the unit dose of drugs contained in the cell are distributed in the storage compartments formed by the partitioning in the storage volume.
  • the bottom of the cuvette being formed of the reinforcement and of a bottom part, called the storage bottom, which is substantially flat
  • the drugs of the unit dose of drugs contained in the cell are distributed in the storage compartments formed by the partitioning, by the storage base and by the cover.
  • One of the storage compartments is then formed by the recess, by the partitioning and by the cover.
  • the storage and distribution device comprises a plurality of storage cells linked to each other in the form of a storage and distribution tray for drugs (or pill box). At least one - in particular each - storage cell of the storage tray is formed by a removable partition, a bowl and a cover forming a storage volume containing a unitary intake of medicines separated from each other.
  • the cover is a sealing sheet of the plurality of cells, the sealing film being formed of a plurality of sealing films, the sheet and the sealing films being sized so that each film of the plurality of sealing films closes the opening of a cuvette of the plurality of cuvettes.
  • each storage cell of the device for the storage and distribution of such drugs contains a unit dose of such drugs corresponding to a medical prescription.
  • the storage cells are linked to each other by pre-cutouts adapted to allow the separation of each cell from adjacent cells by manual tearing of these pre-cuts.
  • the sealing sheet has pre-cuts arranged to allow separation of films from the sealing sheet.
  • the blanking sheet pre-cuts extend in correspondence with pre-cuts of the plurality of storage cuvettes and with pre-cuts of the plurality of removable partitions, so as to allow separation of a single cell from the plurality of cells. for the distribution of a single unit dose of medication to a patient.
  • the pre-cuts are adapted to allow the separation of a cell by simultaneous tearing of the various pre-cuts in a single gesture, manually.
  • the storage and distribution device in the form of a tray has a plurality of eyelets for hooking and storing the tray in a vertical position.
  • the invention also extends to a method of providing a unit dose of medicaments in divided solid dosage form, in which a device according to the invention is used.
  • the invention therefore also extends to a method of supplying a unit dose of medicaments in divided solid dosage form, in which a device according to the invention is used.
  • the cover is removed and the removable partition is extracted simultaneously, the removable partition being integral with the cover.
  • a bottom part of the bowl forming a recess for collecting and crushing - in particular for grinding - medicaments of the unit intake of medicaments dimensioned to be able to receive the medicaments and contain them, the medicaments are moved in the recess after extraction from the removable partitioning and a crushing - in particular a grinding - of the medicaments of the unitary medicament intake is carried out in the recess.
  • the crushing - in particular the grinding - is carried out by any suitable means.
  • the crushing and / or grinding is carried out, for example, by means of a pestle, the recess acting as a crushing mortar.
  • a crushing is carried out by rotating the pestle along an axis substantially orthogonal to the opening plane of the bowl, the pestle exerting compression of the drugs in the recess and their crushing.
  • the recess has a shape that is substantially symmetrical in revolution - in particular cylindrical in revolution - and adapted to be able to allow the drugs to be grouped together in the recess and to cooperate with such a pestle and to allow the drugs to be crushed.
  • the surface-mounted bowl is placed in a concave support formed of a solid material and having a hollow shape complementary to the convex external face of the bowl.
  • a concave support formed of a solid material and having a hollow shape complementary to the convex external face of the bowl.
  • a runny food is added to the unit dose of crushed drugs and the mixture of the runny food and the unit dose of drugs is distributed to the patient.
  • the invention also relates to a device for packaging at least one unit dose of medicaments, a method of packaging at least one unit dose for medicaments in which a packaging device according to the invention is chosen, a device for storing and distributing at least one unit dose of medicaments and a method for distributing at least one unit dose for medicaments to a patient, characterized in combination by all or part of the characteristics mentioned above or below.
  • the packaging devices and the storage and distribution devices for at least one unit dose of medicaments according to the invention shown in figures 1 to 8 are given only by way of non-limiting examples. In these figures, the scales and the relative dimensions are not necessarily respected.
  • a packaging device 1 according to the invention shown in figure 1 comprises a cuvette 11 for storing a unit dose of drugs.
  • the bowl 11 shown in figure 1 is drug-free.
  • the cuvette 11 is formed of a compatible material so as to be able to be brought into contact with the drugs of the unit dose.
  • the bowl 11 is preferably formed from a single piece of a thermoplastic material, for example polyvinyl chloride (PVC) or a thermosetting material.
  • the bowl 11 may for example be obtained by thermoforming the thermoplastic material.
  • the thermoplastic material is preferably transparent and allows visualization of the unit dose of medicaments packaged in the device 1 in the assembled state, packed with medicaments and ready for use by a patient.
  • the cuvette 11 has a volume 15 for storing a unitary intake of medicaments limited by substantially flat side walls 14 and by a bottom 16 which is also substantially flat.
  • the side walls 14 and the bottom 16 provide a through opening of the bowl 11 and of the storage volume 15.
  • the bowl 11 shown in figure 1 being of substantially rectangular parallelepiped shape, the opening of the bowl 11 is rectangular in shape and has an internal rim 17 for receiving and centering the removable partition 13 and a peripheral shoulder 18 for bonding the cover 12 to the substantially flat upper face of the peripheral shoulder 18.
  • the internal rim 17 has a substantially planar upper face capable of cooperating with a complementary lower face of a peripheral rim 19 of the removable partition 13.
  • the peripheral shoulder 18 may have a discontinuity 3 adapted and dimensioned to be able to receive a tab 2 for gripping the removable partition 13.
  • the peripheral shoulder 18 of the opening of the cup 11 being rectangular in shape, the discontinuity 3 preferably extends to one of the longitudinal ends of the cup 11. It is possible that the peripheral shoulder 18 has at least another lateral discontinuity 4 extending in the length of the bowl and adapted (s) to receive a breakable connecting tab 5 extending between two adjacent removable partitions 13.
  • the device shown in figure 1 has a removable partition 13 adapted and sized to be able to be positioned in the storage volume 15 of the bowl 11.
  • the removable partition 13 has a plurality of transverse partitions 6 adapted to provide, with the bowl 11 and the cover 12, a plurality of medicine storage compartments 20 for a unit dose of medicines.
  • the medicaments in the unitary medicament intake are then separated from each other by the transverse partitions 6 during their storage.
  • Each transverse partition 6 shown in figure 1 has two main faces that are not parallel and form in the cuvette 11 compartments 20 flared towards the bottom 16 of the cuvette by increasing the surface of the bottom of the cuvette accessible to the drugs of the unit dose and improving the distribution of these drugs at the bottom of the bowl.
  • each transverse partition having two non-parallel main faces they form in the bowl compartments flared upwards, that is to say compartments in which the opening has a surface greater than the surface of the background.
  • Such upward flared compartments allow easier access to the compartments during their filling. Combining these two advantages, nothing prevents each transverse partition from having two parallel main faces.
  • the removable partition 13 has a peripheral rim 19 of the removable partition adapted to cooperate with the internal rim 17 of the bowl 11 and so that the substantially planar upper face of the peripheral shoulder 18 and the upper face of the peripheral rim 19 of the removable partitions are coplanar and can, if necessary, form with each other the bonding surface of the cover 12.
  • the device shown in figure 1 has a cover 12 sized to close the storage volume 15.
  • This cover 12 can be formed from an adhesive material on only one of its main faces, called the adhesive face. It can be an adhesive cellulosic material, in particular adhesive paper.
  • One of the main faces of the cover 12 is adapted to be placed opposite the storage volume 15 and provided with a layer of an adhesive material protected by a protective film over the entire surface of the cover 12, when the device 1 according to the invention is in the dissociated state (in the form of a “kit”), the cuvette 11, the cover 12 and the removable partition 13 being adapted to be able to form a closed cell for storing a unit dose of drugs, containing the unit intake of drugs, or when the device 1 according to the invention is in the partially assembled state, that is to say in which the removable partition 13 is arranged in the storage volume 15 forming, in cooperation with the bowl 11, drug storage compartments 20, the cover 12 not blocking the opening of the bowl 11.
  • a peripheral part of the protective film of the cover 12 is capable of being able to be removed so that the corresponding peripheral part of the cover 12 can be glued to the peripheral shoulder 18 of the opening of the bowl 11, the unit dose of medicaments being distributed in the medicine storage compartments 20.
  • the device 1 is a device for storing a unitary medication intake, lined with medication and ready to be used by a patient.
  • a peripheral part of the protective film of the cover 12 is capable of being able to be removed so that the corresponding peripheral part of the cover 12 can be glued to the peripheral shoulder 18 of the opening of the bowl 11, the unit dose of drugs being distributed in the medicine storage compartments 20.
  • the cover also has a main face opposite the adhesive face having inscriptions 9 that can be read by the patient, by medical personnel or by a barcode or QR code reader.
  • the entries 9 may relate to the identity of the patient and / or the date and time of the unit taking the medication and / or the medical prescription, in particular the nature, dose and dosage of the drug. (medication).
  • the cover 12 has a precut 8 adapted to allow the opening of the cell 10 for storing the unit dose of drugs.
  • the cover 12 also has a tab 7 for opening the cell 10 adapted to allow the patient to grasp the end of the cover 12, tear the cover 12 according to the pre-cut 8, remove the removable partition 13 from the bowl 11, and forming the unit dose of drugs.
  • the cover 12 is glued only on the peripheral shoulder 18 of the bowl 11 and, where appropriate, on the end of the gripping tongue 2 of the removable partition 13.
  • the opening of the cell 10 by tearing the cover 12 along the pre-cut 8 is not accompanied by the simultaneous extraction of the removable partition 13.
  • a subsequent step of extracting the removable partition 13 is necessary to form the unit intake of drugs in the cuvette 11.
  • the precut 8 is chosen and sized to allow the subsequent step of extracting the drug. removable partition 13 without requiring additional tearing of the cover 12.
  • the cover 12 is glued to the peripheral shoulder 18 of the bowl 11 and to the peripheral rim 19 of the removable partition 13.
  • the tearing of the cover 12 along the precut 8 positioned between the bonding zone of the peripheral shoulder 18 of the bowl 11 and the bonding zone of the peripheral rim 19 of the removable partition 13 is accompanied by the opening of the storage cell 10 but also and simultaneously of the extraction of the partition 13 removable.
  • a second variant of a device 1 according to the invention shown in figure 2 comprises a plurality of storage bowls 21 associated with one another.
  • the storage cuvettes 21 are drug-free.
  • the plurality of storage cuvettes 21 is organized in the form of a column of 7 cuvettes 11, each cuvette 11 corresponding to a daily intake of drugs.
  • the device 1 according to the invention shown in figure 2 therefore allows a unitary daily intake of medication, once a day, for 7 days. Of course, nothing prevents the device 1 according to the invention having 4 columns of 7 cuvettes 11, each column of 7 cuvettes 11 corresponding to one of the 4 daily intakes (breakfast, lunch, supper and bedtime) of drugs.
  • the device 1 according to the invention can therefore be a weekly pill dispenser.
  • Each cuvette 11 of the plurality of medicine storage cuvettes 21 is separated from the adjacent cuvettes 11 by a connection provided with a precut 24 for separating the cuvettes 11.
  • Each removable partition 13 of the plurality of removable partitions 23 is separated from the partitions 13. removable adjacent by a tab 5 for breakable connection and separation of the removable partitions 13.
  • Each cover 12 of the plurality of covers 22 is separated from the adjacent covers 12 by a precut 27 for separating the covers 12.
  • FIG. 3 An exploded view in longitudinal section in the midplane of a drug-free storage cell 10 is shown in figure 3 .
  • the storage cell 10 comprises a basin 11 determining a volume 15 dedicated to the storage of medicaments, limited by flat side walls 14 and by a bottom 16 which is also flat.
  • the bowl 11 has a rim 17 internal shaped to be able to support and center, in combination with a shoulder 18, the removable partition 13 in the bowl 11.
  • the bowl 11 also has a peripheral shoulder 18 for bonding the cover 12 on the flat upper face of the peripheral shoulder 18.
  • the removable partition 13 has a plurality of transverse partitions 6 adapted to be able, in cooperation with the bowl 11 when the peripheral rim 19 of the removable partition 13 rests on the internal rim 17 of the bowl 11, form a plurality of compartments 20 for storing drugs in a single drug intake, the drugs being separated from each other.
  • a peripheral part of the protective film of the cover 12 can be removed so that the corresponding peripheral part of the cover 12 forms an adhesive edge 25 and can be glued to the peripheral shoulder 18 of the opening of the bowl 11, the unit dose of drugs being distributed in the compartments 20 for storing drugs.
  • the removable partition 13 does not adhere to the cover 12 so that it is not extracted from the bowl when the cell 10 is opened.
  • the figure 4 shows a device according to a first variant of the invention formed of a single cell 10 in the state provided with a unitary intake of drugs.
  • the cell 10 comprises a storage cuvette 11, a removable partition 13 disposed in the volume formed by the cuvette 11 and a cover 12 glued to the peripheral shoulder 18 of the cuvette 11.
  • Medicines 26 in divided solid dosage form - in particular not completely powdered, preferably non-powdered - are arranged in at least two storage compartments 20.
  • the drugs 26 are likely to be able to be in contact with the protective film of the adhesive layer over the entire surface of the cover 12 without adhering to the cover and without altering the properties of the drugs 26.
  • the drugs 26 are not likely to be able to be in contact. with the adhesive layer part of the cover 12 free of protective film and glued to the shoulder 18 peripheral of the bowl 11.
  • a device 1 according to the invention in a state of providing a patient with a unitary dose of medication is shown in longitudinal section in the median plane at the figure 5 .
  • This device 1 is formed from a cell 10 as shown in figure 4 and comprising a unit dose of drugs.
  • the cover 12 is associated by peripheral gluing with the removable partition 13 so that the opening of the cell by tearing off the cover 12 along the opening cutouts of the cover 12 is accompanied by extraction of the partition. 13 removable from the bowl 11 and a release of drugs from the unit dose of drugs in the bowl 11.
  • FIG. 6 A particular aspect of a packaging device 1 according to the invention is shown in figure 6 .
  • the cover 12 and the removable partition 13 are as described in figure 1 .
  • the packaging device 1 shown in figure 6 has a cuvette 11 devoid of drugs.
  • the bowl 11 is formed from a single piece of a thermoplastic material, for example polyvinyl chloride (PVC).
  • PVC polyvinyl chloride
  • the bowl 11 may for example be obtained by thermoforming the thermoplastic material.
  • the bowl 11 defines a volume 15 for storing the unitary medication intake limited by substantially flat side walls 14 and by a bottom 16 which is also substantially flat.
  • the bowl 11 shown in figure 6 has a bottom 16 comprising a bottom 30 for storing drugs.
  • the drug storage bottom 30 is substantially flat and extends, when the removable partition 13 is placed in the storage volume of the bowl 11, facing the transverse partitions 6 of the partition and forms with these transverse partitions 6 compartments 20 keeping the drugs in a single dose, separate from each other.
  • the bottom 16 of the bowl 11 shown in figure 6 has a recess 31 forming a receptacle for drugs of a unit dose of drugs.
  • the recess 31 can have any shape. Preferably the recess 31 is of symmetrical shape of revolution.
  • the recess 31 has a mechanical strength chosen to allow crushing and / or grinding of the drugs contained in the recess.
  • the recess 31 is formed of a material whose mechanical resistance, in particular mechanical resistance to abrasion, and the thickness are chosen to allow crushing and / or grinding.
  • the material forming the recess 31 is chosen so as to be able to be in contact with a food and to allow the mixture of the crushed / ground drugs with a flowing food and the setting of the mixture formed by the patient.
  • the recess 31 forms a mortar for crushing and / or grinding the medicaments of the unitary medicament intake.
  • the nature and thickness of the material forming the recess is adapted so as to allow the drugs to be crushed.
  • the nature and thickness of this material is adapted according to the drug crushing method using either a pestle or an external electrical crushing device.
  • the recess may have a substantially smooth internal surface. However, nothing prevents at least a part of the internal surface of the recess from having asperities (or “teeth”) cooperating with the pestle to crush the medicaments.
  • the bottom 16 of the bowl 11 is flat, smooth and allows a sliding of the medicaments of the unit dose of medicaments from the bottom 30 of the medicament storage towards the recess 31 by simply tilting the bowl.
  • a device 1 according to a particular aspect of the invention in a state of providing a patient with a unit dose of medication is shown in longitudinal section in the median plane at the bottom. figure 7 .
  • This device 1 is formed from a cell 10 as shown in figure 5 .
  • the cover 12 is associated by peripheral gluing with the removable partition 13 so that the opening of the cell by tearing off the cover 12 along the opening cutouts of the cover 12 is accompanied by extraction of the partition. 13 removable from the cuvette 11, a release of the drugs from the unit dose of drugs in the cuvette 11 and a sliding of the drugs from the unit dose drugs from the drug storage bottom 30 to the recess 31 by simply tilting the bowl 11.
  • the drugs in the unit dose of drugs confined in the recess 31 are likely to be crushed in the recess 31 so as to form a powder, the powder then being mixed with a runny food such as a jam or a compote so that it can be consumed more easily by the patient.
  • the crushing and / or grinding of the drugs of the plurality of drugs is carried out by any suitable means, for example by means of a pestle 40 as shown in figure 8 , the recess 31 acting as a crushing mortar.
  • the pestle 40 is used in the usual manner, by exerting with the pestle 40 a pressure on the drugs held between the recess 31 and the pestle 40 and by imparting to the pestle 40 a rotational movement causing the crushing / grinding of the drugs.
  • the duration of the crushing / grinding is adapted according to the desired particle size for the unit intake of crushed drugs.
  • the opening of the cell by tearing off the cover according to the opening cutouts of the cover does not occur. not accompanied by simultaneous extraction of the removable partition from the bowl.
  • the invention also relates to a method of packaging at least one unit dose of medicaments in divided solid dosage form with a view to its storage and distribution.
  • a device according to the invention comprising at least one storage cuvette for a unitary medication intake, at least one removable partition and at least one cover.
  • Each removable partition is placed in a cuvette so as to provide in each cuvette a plurality of compartments adapted to be able to maintain the medicaments of the unit dose separated from each other. other.
  • Medicines corresponding to a medical prescription are then placed in each compartment of each cell, then the cell (s) is closed by applying a cover to the opening of each cell.
  • the unit dose of medication and the device according to the invention provided with the unit dose of medication are then ready to be distributed to a patient.
  • FR 2 942 132 We choose a tray, called weekly tray, of cuvettes associated with each other by detachable links and distributed in 4 columns and 7 lines corresponding to four daily intakes (breakfast, lunch, dinner, bedtime) for 7 days.
  • a removable partition in each bowl It may be a plurality of removable partitions associated with each other by breakable links according to a configuration chosen so that each removable partition of the plurality of removable partitions is arranged in the volume of a bowl.
  • the tray of cuvettes equipped with removable partitions is placed on a monitor of a computer system equipped with software for analyzing a medical prescription, representing the distribution of the drugs of this medical prescription in two dimensions in each compartment of each cuvette of the cuvette tray and aid in dispensing medication according to medical prescription.
  • a computer system equipped with software for analyzing a medical prescription, representing the distribution of the drugs of this medical prescription in two dimensions in each compartment of each cuvette of the cuvette tray and aid in dispensing medication according to medical prescription.
  • the compartments in which the drugs of the single drug intake must be placed are visualized through the cuvette (s).

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Claims (19)

  1. Vorrichtung (1) zum Verpacken mindestens einer einzelnen Arzneimitteleinnahme in aufgeteilter fester Darreichungsform, die mindestens eine Lager- und Abgabezelle (10) einer solchen einzelnen Einnahme bildet, wobei jede Zelle umfasst:
    - eine Mulde (11), die ein Lagervolumen (15) einer solchen einzelnen Einnahme begrenzt;
    - einen Deckel (12), ausgeführt, um das Lagervolumen zu schließen;
    - eine Unterteilung (13), ausgeführt, um sich in dem Lagervolumen der Mulde erstrecken, und dort eine Vielzahl von Fächern (20) begrenzen zu können, die es ermöglichen, die Arzneimittel der einzelnen Einnahme voneinander getrennt zu halten;
    wobei die Unterteilung (13), die sich in der Mulde (11) erstreckt, in Bezug auf die Mulde (11) herausnehmbar ist;
    dadurch gekennzeichnet, dass die herausnehmbare Unterteilung (13) eine Unterteilung ohne Boden ist.
  2. Vorrichtung nach Anspruch 1, dadurch gekennzeichnet, dass die Mulde (11) einen umlaufenden Ansatz (18) aufweist, der eine Öffnung der Mulde (11) begrenzt, wobei der Deckel (12) aus einem Verschlussfilm gebildet ist, der ausgeführt ist, um an dem umlaufenden Ansatz der Mulde (11) anzuhaften.
  3. Vorrichtung nach Anspruch 2, dadurch gekennzeichnet, dass der Verschlussfilm eine, Haftseite genannte, Hauptseite aufweist, die mindestens eine Haftzone aufweist, die angeordnet ist, um an dem umlaufenden Ansatz der Mulde anzuhaften.
  4. Vorrichtung nach Anspruch 3, dadurch gekennzeichnet, dass der Verschlussfilm eine zweite, bedruckte Seite genannte, Hauptseite gegenüber der Haftseite aufweist, und mindestens eine Aufschrift aufweist.
  5. Vorrichtung nach einem der Ansprüche 1 bis 4, dadurch gekennzeichnet, dass die Mulde (11) in einer in einer Hauptausdehnungsrichtung ausgedehnten Form ist, und Folgendes aufweist:
    - eine größere Abmessung parallel zu der Hauptausdehnungsrichtung der Mulde, mit einem Wert, der zwischen 60 mm und 150 mm enthalten ist, und;
    - eine Breite in einer Richtung senkrecht zu der Hauptausdehnungsrichtung, mit einem Wert, der zwischen 20 mm und 50 mm enthalten ist.
  6. Vorrichtung nach Anspruch 5, dadurch gekennzeichnet, dass die Mulde eine Tiefe aufweist, die sich senkrecht zu der Hauptausdehnungsrichtung, senkrecht zu der Breite erstreckt, und mit einem Wert kleiner als die Breite, insbesondere zwischen 10 mm und 20 mm enthalten.
  7. Vorrichtung nach einem der Ansprüche 1 bis 6, dadurch gekennzeichnet, dass sie ausgeführt ist, um eine Vielzahl von Lagerzellen (10) einer Vielzahl von einzelnen Einnahmen solcher Arzneimittel bilden zu können, wobei die Zellen der Vielzahl von Lagerzellen (10) miteinander in Form einer Lager- und Abgabeplatte von Arzneimitteln miteinander verbunden sind.
  8. Vorrichtung nach einem der Ansprüche 1 bis 7, dadurch gekennzeichnet, dass sie umfasst:
    - eine vorausgeschnittene Arzneimittelaufnahmeplatte, die eine Vielzahl von nebeneinandergestellten Mulden (11) bildet;
    - einen vorausgeschnittenen Bogen von Verschlussfilmen, und;
    - eine vorausgeschnittene Einheit an herausnehmbaren Unterteilungen (13).
  9. Vorrichtung nach einem der Ansprüche 1 bis 8, dadurch gekennzeichnet, dass ein Bodenteil (16) der Mulde (11) eine Vertiefung (31) zum Sammmeln der Arzneimittel der einzelnen Arzneimitteleinnahme bildet, die ausgeführt ist, um die Arzneimittel aufnehmen, und sie enthalten zu können, und um deren Zerstoßen in der Vertiefung (31) zu ermöglichen.
  10. Vorrichtung nach Anspruch 9, dadurch gekennzeichnet, dass die Vertiefung (31) eine Vertiefung ist, die zwischen einer eingezogenen Form, in der die Vertiefung das Zerstoßen der Arzneimittel nicht ermöglicht, und einer ausgebreiteten Form verformbar ist, in der die Vertiefung eine Tiefe aufweist, die angepasst ist, um die Arzneimittel aufzunehmen und deren Zerstoßen zu ermöglichen.
  11. Verfahren zum Verpacken mindestens einer einzelnen Einnahme von Arzneimitteln in aufgeteilter fester Darreichungsform, wobei:
    - eine Vorrichtung (1) zum Verpacken nach einem der Ansprüche 1 bis 10 ausgewählt wird;
    - eine herausnehmbare Unterteilung (13) in einer Mulde (11) der Vorrichtung (1) zum Verpacken platziert wird;
    - Arzneimittel in aufgeteilter fester Darreichungsform, in mindestens zwei Lagerfächer (20) geteilt, die durch herausnehmbare Unterteilungen (13) gebildet werden, die in der Mulde (11) platziert sind, verteilt werden und;
    - die Mulde (11) der Vorrichtung, die die Arzneimittel umfasst, durch Anlegen eines Deckels (12) geschlossen wird.
  12. Verfahren nach Anspruch 11, dadurch gekennzeichnet, dass:
    - eine herausnehmbare Unterteilung (13) in jeder Mulde (11) der Vorrichtung (1) zum Verpacken platziert wird;
    - Arzneimittel in aufgeteilter fester Darreichungsform, in mindestens zwei Lagerfächer (20) geteilt, die durch herausnehmbare Unterteilungen (13) gebildet werden, die in der Mulde (11) platziert sind, verteilt werden, und;
    - die Mulde (11) der Vorrichtung, die die Arzneimittel umfasst, durch Anlegen eines Deckels (12) geschlossen wird.
  13. Vorrichtung zum Lagern und Ausgeben mindestens einer einzelnen Arzneimitteleinnahme in aufgeteilter fester Darreichungsform, umfassend eine Vorrichtung nach einem der Ansprüche 1 bis 10, wobei jede einzelne Einnahme dazu bestimmt ist, einem Patienten zu einem vorbestimmten Zeitpunkt, und in einer Lager- und Abgabezelle (10) einer solchen einzelnen Einnahme verteilt, verabreicht zu werden, wobei jede Zelle umfasst:
    - die Mulde (11), die eine solche einzelne Einnahme enthält;
    - die Unterteilung (13), die sich in dem Lagervolumen der Mulde (11) erstreckt und dort eine Vielzahl von Fächern (20) begrenzt, die die Arzneimittel der einzelnen Einnahme voneinander getrennt halten.
  14. Vorrichtung nach Anspruch 13, dadurch gekennzeichnet, dass die herausnehmbare Unterteilung (13) fest mit dem Deckel verbunden ist, um beim Öffnen der Lagerzelle (10) ein gleichzeitiges Extrahieren der herausnehmbaren Unterteilung (13) aus der Mulde (11) heraus, und eine zufällige Verteilung der Arzneimittel in der Mulde (11) zu ermöglichen.
  15. Vorrichtung nach Anspruch 13, dadurch gekennzeichnet, dass die herausnehmbare Unterteilung (13) derart von dem Deckel getrennt ist, dass das Öffnen der Lagerzelle (10) ein zeitversetztes Extrahieren der herausnehmbaren Unterteilung (13) aus der Mulde (11) heraus nötig macht, um eine zufällige Verteilung der Arzneimittel in der Mulde (11) zu bilden.
  16. Vorrichtung nach einem der Ansprüche 13 bis 15, dadurch gekennzeichnet, dass ein Bodenteil (16) der Mulde (11) eine Vertiefung (31) zum Sammeln der Arzneimittel der einzelnen Arzneimitteleinnahme bildet, die ausgeführt ist, um die Arzneimittel aufnehmen, und sie enthalten zu können, und um deren Zerstoßen in der Vertiefung (31) zu ermöglichen.
  17. Verfahren zur Ausgabe mindestens einer einzelnen Arzneimitteleinnahme in aufgeteilter fester Darreichungsform an einen Patienten, wobei:
    - eine Lager- und Abgabevorrichtung mindestens einer einzelnen Einnahme von Arzneimitteln in aufgeteilter fester Darreichungsform nach einem der Ansprüche 13 bis 16 ausgewählt wird;
    - eine Lager- und Abgabezelle (10) einer solchen einzelnen Einnahme von der Lagervorrichtung getrennt wird;
    - der Deckel dieser Zelle (10) der Lager- und Abgabevorrichtung entsprechend der einzelnen Arzneimitteleinnahme entfernt wird, und;
    - die herausnehmbare Unterteilung (13) aus dieser Zelle (10) derart extrahiert wird, dass die Arzneimittel in der Mulde (11) nicht mehr voneinander getrennt sind, und;
    - die einzelne Arzneimitteleinnahme an den Patienten abgegeben wird.
  18. Verfahren nach Anspruch 17, dadurch gekennzeichnet, dass der Deckel (12) entfernt wird, und die herausnehmbare Unterteilung (13) gleichzeitig extrahiert wird, wobei die herausnehmbare Unterteilung (13) fest mit dem Deckel (12) verbunden ist.
  19. Verfahren nach einem der Ansprüche 17 oder 18, dadurch gekennzeichnet, dass ein Bodenteil (16) der Mulde (11) eine Vertiefung (31) zum Sammeln und Zerstoßen der Arzneimittel der einzelnen Einnahme bildet, die bemessen ist, um die Arzneimittel aufzunehmen und sie zu enthalten, die Arzneimittel nach dem Extrahieren der herausnehmbaren Unterteilung (13) in die Vertiefung (31) verschoben werden, und ein Zerstoßen der Arzneimittel der einzelnen Arzneimitteleinnahme in der Vertiefung (31) durchgeführt wird.
EP17725323.4A 2016-05-04 2017-05-02 Vorrichtung und verfahren zum verpacken von festen arzneimitteln, vorrichtung zum lagern und ausgeben solcher arzneimittel sowie abgabeverfahren Active EP3452001B1 (de)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
FR1654048A FR3050931B1 (fr) 2016-05-04 2016-05-04 Dispositif et procede d'emballage de medicaments solides, dispositif de stockage et de distribution de tels medicaments et procede de distribution
FR1753755A FR3050932B1 (fr) 2016-05-04 2017-04-28 Dispositif et procede d'emballage de medicaments solides, dispositif de stockage et de distribution de tels medicaments et procede de distribution
PCT/FR2017/051044 WO2017191405A1 (fr) 2016-05-04 2017-05-02 Dispositif et procédé d'emballage de médicaments solides, dispositif de stockage et de distribution de tels médicaments et procédé de distribution

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EP3452001A1 EP3452001A1 (de) 2019-03-13
EP3452001B1 true EP3452001B1 (de) 2020-09-16

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US (1) US10806677B2 (de)
EP (1) EP3452001B1 (de)
JP (1) JP2019518575A (de)
CN (1) CN109152696B (de)
CA (1) CA3020689A1 (de)
DK (1) DK3452001T3 (de)
ES (1) ES2837447T3 (de)
FR (2) FR3050931B1 (de)
PT (1) PT3452001T (de)
WO (1) WO2017191405A1 (de)

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US10878838B1 (en) 2017-11-16 2020-12-29 Amazon Technologies, Inc. Systems and methods to trigger actions based on encoded sounds associated with containers
US11472598B1 (en) * 2017-11-16 2022-10-18 Amazon Technologies, Inc. Systems and methods to encode sounds in association with containers
FR3076207B1 (fr) * 2017-12-29 2020-01-03 Distraimed Dispositifs et procedes d'emballage, de stockage et de distribution de medicaments
FR3085590B1 (fr) 2018-09-12 2021-01-29 Biogaran Boitier pour le stockage et la delivrance de doses de medicaments a administrer
CN112090110B (zh) * 2020-09-02 2021-10-29 佳木斯大学 植物类中药成分提取设备及方法
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Publication number Publication date
FR3050932B1 (fr) 2022-02-04
DK3452001T3 (da) 2020-12-21
WO2017191405A1 (fr) 2017-11-09
US20190125629A1 (en) 2019-05-02
PT3452001T (pt) 2020-12-07
ES2837447T3 (es) 2021-06-30
JP2019518575A (ja) 2019-07-04
CN109152696A (zh) 2019-01-04
FR3050931A1 (fr) 2017-11-10
FR3050931B1 (fr) 2022-01-07
FR3050932A1 (fr) 2017-11-10
US10806677B2 (en) 2020-10-20
CA3020689A1 (fr) 2017-11-09
EP3452001A1 (de) 2019-03-13
CN109152696B (zh) 2021-06-18

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