EP3408381A1 - Virus de la bronchite infectieuse atténué - Google Patents

Virus de la bronchite infectieuse atténué

Info

Publication number
EP3408381A1
EP3408381A1 EP17703212.5A EP17703212A EP3408381A1 EP 3408381 A1 EP3408381 A1 EP 3408381A1 EP 17703212 A EP17703212 A EP 17703212A EP 3408381 A1 EP3408381 A1 EP 3408381A1
Authority
EP
European Patent Office
Prior art keywords
coronavirus
gene
virus
nsp
seq
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
EP17703212.5A
Other languages
German (de)
English (en)
Other versions
EP3408381B1 (fr
Inventor
Erica Bickerton
Sarah KEEP
Paul Britton
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Pirbright Institute
Original Assignee
Pirbright Institute
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pirbright Institute filed Critical Pirbright Institute
Publication of EP3408381A1 publication Critical patent/EP3408381A1/fr
Application granted granted Critical
Publication of EP3408381B1 publication Critical patent/EP3408381B1/fr
Active legal-status Critical Current
Anticipated expiration legal-status Critical

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    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N7/00—Viruses; Bacteriophages; Compositions thereof; Preparation or purification thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/12—Viral antigens
    • A61K39/215—Coronaviridae, e.g. avian infectious bronchitis virus
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/005—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from viruses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/51—Medicinal preparations containing antigens or antibodies comprising whole cells, viruses or DNA/RNA
    • A61K2039/525—Virus
    • A61K2039/5254—Virus avirulent or attenuated
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/54—Medicinal preparations containing antigens or antibodies characterised by the route of administration
    • A61K2039/541—Mucosal route
    • A61K2039/543—Mucosal route intranasal
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2770/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssRNA viruses positive-sense
    • C12N2770/00011—Details
    • C12N2770/20011—Coronaviridae
    • C12N2770/20021—Viruses as such, e.g. new isolates, mutants or their genomic sequences
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2770/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssRNA viruses positive-sense
    • C12N2770/00011—Details
    • C12N2770/20011—Coronaviridae
    • C12N2770/20022—New viral proteins or individual genes, new structural or functional aspects of known viral proteins or genes
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2770/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssRNA viruses positive-sense
    • C12N2770/00011—Details
    • C12N2770/20011—Coronaviridae
    • C12N2770/20034—Use of virus or viral component as vaccine, e.g. live-attenuated or inactivated virus, VLP, viral protein
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2770/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssRNA viruses positive-sense
    • C12N2770/00011—Details
    • C12N2770/20011—Coronaviridae
    • C12N2770/20051—Methods of production or purification of viral material
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2770/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssRNA viruses positive-sense
    • C12N2770/00011—Details
    • C12N2770/20011—Coronaviridae
    • C12N2770/20061—Methods of inactivation or attenuation
    • C12N2770/20062—Methods of inactivation or attenuation by genetic engineering
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2770/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssRNA viruses positive-sense
    • C12N2770/00011—Details
    • C12N2770/20011—Coronaviridae
    • C12N2770/20071—Demonstrated in vivo effect

Abstract

La présente invention concerne un coronavirus vivant atténué comprenant une mutation de la protéine non structurale nsp-3 et/ou une suppression des protéines accessoires 3a et 3b. Ce coronavirus peut être utilisé en tant que vaccin pour le traitement et/ou la prévention d'une maladie, telle que la bronchite infectieuse, chez un sujet.
EP17703212.5A 2016-01-27 2017-01-26 Virus de la bronchite infectieuse atténué Active EP3408381B1 (fr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GBGB1601498.7A GB201601498D0 (en) 2016-01-27 2016-01-27 Coronavirus
PCT/GB2017/050192 WO2017129975A1 (fr) 2016-01-27 2017-01-26 Virus de la bronchite infectieuse atténué

Publications (2)

Publication Number Publication Date
EP3408381A1 true EP3408381A1 (fr) 2018-12-05
EP3408381B1 EP3408381B1 (fr) 2021-06-23

Family

ID=55535017

Family Applications (1)

Application Number Title Priority Date Filing Date
EP17703212.5A Active EP3408381B1 (fr) 2016-01-27 2017-01-26 Virus de la bronchite infectieuse atténué

Country Status (17)

Country Link
US (1) US11202825B2 (fr)
EP (1) EP3408381B1 (fr)
JP (1) JP2019503693A (fr)
KR (1) KR20180104088A (fr)
CN (1) CN108884447B (fr)
AU (1) AU2017211507B2 (fr)
BR (1) BR112018015453A2 (fr)
CA (1) CA3012024A1 (fr)
CL (1) CL2018001946A1 (fr)
GB (1) GB201601498D0 (fr)
IL (1) IL259655A (fr)
MX (1) MX2018009008A (fr)
PE (1) PE20190121A1 (fr)
PH (1) PH12018501154A1 (fr)
RU (1) RU2018130683A (fr)
WO (1) WO2017129975A1 (fr)
ZA (1) ZA201803700B (fr)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN110592031B (zh) * 2019-09-25 2023-03-14 华南农业大学 一株S蛋白融合HiBiT的传染性支气管炎重组病毒及制备方法与应用
CN111437384A (zh) * 2020-04-07 2020-07-24 四川骋誉生物制品有限公司 用于预防covid-19的蝙蝠源性冠状病毒疫苗
BR102020019867A2 (pt) * 2020-09-28 2022-04-12 Fundacao Univ Estadual Do Ceara Funece Uso da vacina de coronavírus aviário (ibv) como modelo de imunização em mamíferos contra sars-cov 2
JP2024004496A (ja) * 2020-10-14 2024-01-17 一般財団法人阪大微生物病研究会 ノックアウトコロナウイルス
CN113308440B (zh) * 2021-05-26 2023-04-28 武汉大学 一种n7-甲基转移酶缺陷型冠状病毒减毒疫苗株及其制备方法与应用
CN114807061A (zh) * 2021-12-22 2022-07-29 华南农业大学 鸡传染性支气管炎标记疫苗毒株及其制备方法、疫苗

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5037650A (en) 1988-03-08 1991-08-06 Akzo N.V. Live combination vaccine
SK16162000A3 (sk) 1998-05-01 2001-12-03 Schering-Plough Ltd. Rekombinantný vírus exprimujúci cudziu dna kódujúcu mačací cd80, mačací ctla-4 alebo mačací cd86 a jeho použitie
HU228121B1 (en) * 2001-05-17 2012-11-28 Stichting Tech Wetenschapp Corona-virus-like particles comprising functionally deleted genomes
DK1610817T3 (da) 2003-03-03 2010-01-25 Intervet Int Bv Infektiøs bronkitis virus med et ændret spike-gen
RU2253870C1 (ru) 2004-04-26 2005-06-10 Общество с ограниченной ответственностью Научно-производственное объединение "Диагностические системы" РЕКОМБИНАНТНЫЕ БЕЛКИ, СОДЕРЖАЩИЕ ДИАГНОСТИЧЕСКИ ЗНАЧИМЫЕ АНТИГЕННЫЕ ЭПИТОПЫ БЕЛКОВ КОРОНАВИРУСА (SARS-CoV), СВЯЗАННОГО С ТЯЖЕЛЫМ ОСТРЫМ РЕСПИРАТОРНЫМ СИНДРОМОМ, И ПОСЛЕДОВАТЕЛЬНОСТИ СИНТЕТИЧЕСКИХ ГЕНОВ, КОДИРУЮЩИХ ДИАГНОСТИЧЕСКИ ЗНАЧИМЫЕ АНТИГЕННЫЕ ДЕТЕРМИНАНТЫ БЕЛКОВ КОРОНАВИРУСА (SARS-CoV), СВЯЗАННОГО С ТЯЖЕЛЫМ ОСТРЫМ РЕСПИРАТОРНЫМ СИНДРОМОМ
KR100902510B1 (ko) * 2007-08-27 2009-06-15 삼성전자주식회사 한 개의 스위칭 소자와 한 개의 저항체를 포함하는비휘발성 메모리 장치
GB0911794D0 (en) 2009-07-07 2009-08-19 Animal Health Inst Chimaeric protein

Also Published As

Publication number Publication date
CN108884447B (zh) 2022-07-26
CA3012024A1 (fr) 2017-08-03
JP2019503693A (ja) 2019-02-14
CN108884447A (zh) 2018-11-23
BR112018015453A2 (pt) 2018-12-18
RU2018130683A3 (fr) 2020-04-21
AU2017211507A1 (en) 2018-06-28
US11202825B2 (en) 2021-12-21
MX2018009008A (es) 2018-11-19
KR20180104088A (ko) 2018-09-19
RU2018130683A (ru) 2020-02-27
PE20190121A1 (es) 2019-01-17
GB201601498D0 (en) 2016-03-09
IL259655A (en) 2018-07-31
PH12018501154A1 (en) 2019-01-28
US20190022214A1 (en) 2019-01-24
CL2018001946A1 (es) 2019-02-15
WO2017129975A1 (fr) 2017-08-03
ZA201803700B (en) 2022-12-21
EP3408381B1 (fr) 2021-06-23
AU2017211507B2 (en) 2022-09-29

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