EP3390443A4 - Anti-myostatin-antikörper, polypeptide mit abweichenden fc-regionen und verfahren zur verwendung - Google Patents
Anti-myostatin-antikörper, polypeptide mit abweichenden fc-regionen und verfahren zur verwendung Download PDFInfo
- Publication number
- EP3390443A4 EP3390443A4 EP16875757.3A EP16875757A EP3390443A4 EP 3390443 A4 EP3390443 A4 EP 3390443A4 EP 16875757 A EP16875757 A EP 16875757A EP 3390443 A4 EP3390443 A4 EP 3390443A4
- Authority
- EP
- European Patent Office
- Prior art keywords
- regions
- methods
- polypeptides containing
- myostatin antibodies
- containing variant
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/22—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against growth factors ; against growth regulators
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P21/00—Drugs for disorders of the muscular or neuromuscular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P21/00—Drugs for disorders of the muscular or neuromuscular system
- A61P21/02—Muscle relaxants, e.g. for tetanus or cramps
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P21/00—Drugs for disorders of the muscular or neuromuscular system
- A61P21/06—Anabolic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/04—Anorexiants; Antiobesity agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
- C07K2317/24—Immunoglobulins specific features characterized by taxonomic origin containing regions, domains or residues from different species, e.g. chimeric, humanized or veneered
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
- C07K2317/33—Crossreactivity, e.g. for species or epitope, or lack of said crossreactivity
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
- C07K2317/34—Identification of a linear epitope shorter than 20 amino acid residues or of a conformational epitope defined by amino acid residues
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/52—Constant or Fc region; Isotype
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/52—Constant or Fc region; Isotype
- C07K2317/524—CH2 domain
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/52—Constant or Fc region; Isotype
- C07K2317/526—CH3 domain
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/52—Constant or Fc region; Isotype
- C07K2317/53—Hinge
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
- C07K2317/565—Complementarity determining region [CDR]
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
- C07K2317/567—Framework region [FR]
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
- C07K2317/71—Decreased effector function due to an Fc-modification
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
- C07K2317/76—Antagonist effect on antigen, e.g. neutralization or inhibition of binding
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
- C07K2317/92—Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
- C07K2317/94—Stability, e.g. half-life, pH, temperature or enzyme-resistance
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP2015247070 | 2015-12-18 | ||
PCT/JP2016/087487 WO2017104783A1 (en) | 2015-12-18 | 2016-12-16 | Anti-myostatin antibodies, polypeptides containing variant fc regions, and methods of use |
Publications (2)
Publication Number | Publication Date |
---|---|
EP3390443A1 EP3390443A1 (de) | 2018-10-24 |
EP3390443A4 true EP3390443A4 (de) | 2019-11-13 |
Family
ID=59011957
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
EP16875757.3A Pending EP3390443A4 (de) | 2015-12-18 | 2016-12-16 | Anti-myostatin-antikörper, polypeptide mit abweichenden fc-regionen und verfahren zur verwendung |
Country Status (16)
Country | Link |
---|---|
EP (1) | EP3390443A4 (de) |
JP (4) | JP6142069B1 (de) |
KR (3) | KR102501335B1 (de) |
CN (2) | CN108473562B (de) |
AR (1) | AR107078A1 (de) |
AU (1) | AU2016372934B2 (de) |
BR (1) | BR112018011073A2 (de) |
CA (1) | CA3002422C (de) |
EA (1) | EA201891420A1 (de) |
HK (1) | HK1254755A1 (de) |
MX (1) | MX2018007145A (de) |
MY (1) | MY189425A (de) |
PH (1) | PH12018501280A1 (de) |
SG (2) | SG11201610812WA (de) |
TW (3) | TW202231662A (de) |
WO (1) | WO2017104783A1 (de) |
Families Citing this family (25)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
ES2568436T3 (es) | 2006-03-31 | 2016-04-29 | Chugai Seiyaku Kabushiki Kaisha | Procedimiento para controlar la farmacocinética en sangre de anticuerpos |
EP3689912A1 (de) | 2007-09-26 | 2020-08-05 | Chugai Seiyaku Kabushiki Kaisha | Verfahren zur modifizierung eines isoelektrischen punkts eines antikörpers über aminosäuresubstitution in cdr |
EP4238993A3 (de) | 2008-04-11 | 2023-11-29 | Chugai Seiyaku Kabushiki Kaisha | Antigenbindendes molekül zur wiederholten bindung an zwei oder mehr antigenmoleküle |
SG190727A1 (en) | 2010-11-30 | 2013-07-31 | Chugai Pharmaceutical Co Ltd | Antigen-binding molecule capable of binding to plurality of antigen molecules repeatedly |
JPWO2013180200A1 (ja) | 2012-05-30 | 2016-01-21 | 中外製薬株式会社 | 標的組織特異的抗原結合分子 |
TWI697501B (zh) | 2012-08-24 | 2020-07-01 | 日商中外製藥股份有限公司 | FcγRIIb特異性Fc區域變異體 |
JP6774164B2 (ja) | 2012-08-24 | 2020-10-21 | 中外製薬株式会社 | マウスFcγRII特異的Fc抗体 |
WO2014163101A1 (ja) | 2013-04-02 | 2014-10-09 | 中外製薬株式会社 | Fc領域改変体 |
JP7060317B2 (ja) | 2013-12-04 | 2022-04-26 | 中外製薬株式会社 | 化合物の濃度に応じて抗原結合能の変化する抗原結合分子及びそのライブラリ |
TWI808330B (zh) | 2014-12-19 | 2023-07-11 | 日商中外製藥股份有限公司 | 抗肌抑素之抗體、含變異Fc區域之多胜肽及使用方法 |
TW202248212A (zh) | 2015-02-05 | 2022-12-16 | 日商中外製藥股份有限公司 | 包含離子濃度依賴之抗原結合域的抗體、Fc區變體、IL-8結合抗體與其用途 |
WO2017104783A1 (en) * | 2015-12-18 | 2017-06-22 | Chugai Seiyaku Kabushiki Kaisha | Anti-myostatin antibodies, polypeptides containing variant fc regions, and methods of use |
EP3394098A4 (de) | 2015-12-25 | 2019-11-13 | Chugai Seiyaku Kabushiki Kaisha | Anti-myostatin-antikörper und verfahren zur verwendung |
MY193497A (en) * | 2016-06-17 | 2022-10-17 | Chugai Pharmaceutical Co Ltd | Anti-myostatin antibodies and methods of use |
EP3494991A4 (de) | 2016-08-05 | 2020-07-29 | Chugai Seiyaku Kabushiki Kaisha | Zusammensetzung zur vorbeugung oder behandlung von erkrankungen im zusammenhang mit il-8 |
SG11201907288RA (en) | 2017-02-28 | 2019-09-27 | Seattle Genetics Inc | Cysteine mutated antibodies for conjugation |
KR102259473B1 (ko) | 2018-08-10 | 2021-06-02 | 추가이 세이야쿠 가부시키가이샤 | 항cd137 항원 결합 분자 및 그의 사용 |
MX2021012251A (es) * | 2019-04-10 | 2021-11-12 | Chugai Pharmaceutical Co Ltd | Metodo para purificar un anticuerpo modificado en la region de fragmento cristalizable (fc). |
RU2750267C1 (ru) * | 2020-02-07 | 2021-06-25 | Общество с ограниченной ответственностью «НАУЧНО-ПРОИЗВОДСТВЕННОЕ ОБЪЕДИНЕНИЕ ИН-ВЕТ» | Рекомбинантный ростовой дифференцировочный фактор роста 11 (GDF11), способ его получения, инъекционный препарат для повышения мышечной массы млекопитающих животных и птицы, а также способ использования препарата |
TW202144395A (zh) | 2020-02-12 | 2021-12-01 | 日商中外製藥股份有限公司 | 用於癌症之治療的抗cd137抗原結合分子 |
WO2023057404A1 (en) | 2021-10-06 | 2023-04-13 | F. Hoffmann-La Roche Ag | Novel combined administration |
WO2023187022A1 (en) | 2022-04-01 | 2023-10-05 | F. Hoffmann-La Roche Ag | New treatment for facioscapulohumeral muscular dystrophy (fshd) |
US11780910B1 (en) | 2022-05-02 | 2023-10-10 | Novo Nordisk A/S | Anti-ANGPTL3 antibodies suitable for high concentration compositions and subcutaneous administration |
WO2024081932A1 (en) | 2022-10-14 | 2024-04-18 | Genentech, Inc. | Methods for treating spinal muscular atrophy |
CN116990528B (zh) * | 2023-09-27 | 2024-02-06 | 成都华西海圻医药科技有限公司 | 一种基于Gyrolab平台快速测定抗CD40单抗的分析方法 |
Citations (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2003027248A2 (en) * | 2001-09-26 | 2003-04-03 | Wyeth | Antibody inhibitors of gdf-8 and uses thereof |
EP2889377A1 (de) * | 2012-08-24 | 2015-07-01 | Chugai Seiyaku Kabushiki Kaisha | Fc-riib-spezifische fc-regionsvariante |
EP3240804A1 (de) * | 2014-12-19 | 2017-11-08 | Chugai Seiyaku Kabushiki Kaisha | Anti-myostatin-antikörper, polypeptide mit abweichenden fc-regionen und verfahren zur verwendung |
Family Cites Families (17)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US7261893B2 (en) * | 2002-10-22 | 2007-08-28 | Wyeth | Neutralizing antibodies against GDF-8 and uses therefor |
EP1797127B1 (de) * | 2004-09-24 | 2017-06-14 | Amgen Inc. | Modifizierte fc-moleküle |
US8008453B2 (en) * | 2005-08-12 | 2011-08-30 | Amgen Inc. | Modified Fc molecules |
PT2066695E (pt) * | 2006-09-05 | 2013-05-23 | Lilly Co Eli | Anticorpos anti-miostatina |
PE20091163A1 (es) * | 2007-11-01 | 2009-08-09 | Wyeth Corp | Anticuerpos para gdf8 |
EP4238993A3 (de) * | 2008-04-11 | 2023-11-29 | Chugai Seiyaku Kabushiki Kaisha | Antigenbindendes molekül zur wiederholten bindung an zwei oder mehr antigenmoleküle |
AR074777A1 (es) * | 2008-12-19 | 2011-02-09 | Glaxo Group Ltd | Proteinas de union a antigeno |
CN102844332B (zh) * | 2010-03-11 | 2015-08-19 | 瑞纳神经科学公司 | 呈pH依赖性抗原结合的抗体 |
AR081556A1 (es) * | 2010-06-03 | 2012-10-03 | Glaxo Group Ltd | Proteinas de union al antigeno humanizadas |
LT2825036T (lt) * | 2012-03-16 | 2018-07-10 | Regeneron Pharmaceuticals, Inc. | Histidino pakeitimus lengvoje grandinėje turintys antikūnai ir genetiškai modifikuoti graužikai, išvesti ju gamybai |
TWI619729B (zh) * | 2012-04-02 | 2018-04-01 | 再生元醫藥公司 | 抗-hla-b*27抗體及其用途 |
NZ704771A (en) * | 2012-08-13 | 2018-02-23 | Regeneron Pharma | Anti-pcsk9 antibodies with ph-dependent binding characteristics |
EP3816625A1 (de) * | 2013-05-06 | 2021-05-05 | Scholar Rock, Inc. | Zusammensetzungen und verfahren zur modulation von wachstumsfaktoren |
RU2016108652A (ru) * | 2013-08-14 | 2017-09-14 | Новартис Аг | Способы лечения спорадического миозита с тельцами включений |
JP6706617B2 (ja) * | 2014-11-06 | 2020-06-10 | スカラー ロック インコーポレイテッドScholar Rock,Inc. | 抗プロ/潜在型−ミオスタチン抗体およびその使用 |
WO2016073906A2 (en) * | 2014-11-06 | 2016-05-12 | Scholar Rock, Inc. | Transforming growth factor-related immunoassays |
WO2017104783A1 (en) * | 2015-12-18 | 2017-06-22 | Chugai Seiyaku Kabushiki Kaisha | Anti-myostatin antibodies, polypeptides containing variant fc regions, and methods of use |
-
2016
- 2016-12-16 WO PCT/JP2016/087487 patent/WO2017104783A1/en active Application Filing
- 2016-12-16 EP EP16875757.3A patent/EP3390443A4/de active Pending
- 2016-12-16 AR ARP160103887A patent/AR107078A1/es unknown
- 2016-12-16 MY MYPI2018702306A patent/MY189425A/en unknown
- 2016-12-16 AU AU2016372934A patent/AU2016372934B2/en active Active
- 2016-12-16 JP JP2016244254A patent/JP6142069B1/ja active Active
- 2016-12-16 EA EA201891420A patent/EA201891420A1/ru unknown
- 2016-12-16 KR KR1020187001235A patent/KR102501335B1/ko active IP Right Grant
- 2016-12-16 TW TW110149330A patent/TW202231662A/zh unknown
- 2016-12-16 CN CN201680072782.7A patent/CN108473562B/zh active Active
- 2016-12-16 SG SG11201610812WA patent/SG11201610812WA/en unknown
- 2016-12-16 TW TW106129765A patent/TWI749057B/zh active
- 2016-12-16 BR BR112018011073A patent/BR112018011073A2/pt active Search and Examination
- 2016-12-16 TW TW105141729A patent/TWI605057B/zh active
- 2016-12-16 CA CA3002422A patent/CA3002422C/en active Active
- 2016-12-16 SG SG10201707267RA patent/SG10201707267RA/en unknown
- 2016-12-16 CN CN202210678733.5A patent/CN115028721A/zh active Pending
- 2016-12-16 MX MX2018007145A patent/MX2018007145A/es unknown
- 2016-12-16 KR KR1020177003241A patent/KR101820637B1/ko active IP Right Grant
- 2016-12-16 KR KR1020237005092A patent/KR20230027321A/ko not_active Application Discontinuation
-
2017
- 2017-05-08 JP JP2017092151A patent/JP7053164B2/ja active Active
-
2018
- 2018-06-14 PH PH12018501280A patent/PH12018501280A1/en unknown
- 2018-10-29 HK HK18113798.7A patent/HK1254755A1/zh unknown
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2022
- 2022-03-31 JP JP2022058710A patent/JP2022097485A/ja active Pending
-
2023
- 2023-11-29 JP JP2023201204A patent/JP2024023427A/ja active Pending
Patent Citations (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2003027248A2 (en) * | 2001-09-26 | 2003-04-03 | Wyeth | Antibody inhibitors of gdf-8 and uses thereof |
EP2889377A1 (de) * | 2012-08-24 | 2015-07-01 | Chugai Seiyaku Kabushiki Kaisha | Fc-riib-spezifische fc-regionsvariante |
EP3240804A1 (de) * | 2014-12-19 | 2017-11-08 | Chugai Seiyaku Kabushiki Kaisha | Anti-myostatin-antikörper, polypeptide mit abweichenden fc-regionen und verfahren zur verwendung |
Non-Patent Citations (1)
Title |
---|
JOHN O RICHARDS ET AL: "Optimization of antibody binding to FcãRIIa enhances macrophage phagocytosis of tumor cells", MOLECULAR CANCER THERAPEUTICS, AMERICAN ASSOCIATION FOR CANCER RESEARCH, US, vol. 7, no. 8, 1 August 2008 (2008-08-01), pages 2517 - 2527, XP002631327, ISSN: 1535-7163, DOI: 10.1158/1535-7163.MCT-08-0201 * |
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