EP3333523A1 - Bouchon de récipient destiné à être utilisé lors de la lyophilisation - Google Patents
Bouchon de récipient destiné à être utilisé lors de la lyophilisation Download PDFInfo
- Publication number
- EP3333523A1 EP3333523A1 EP16202437.6A EP16202437A EP3333523A1 EP 3333523 A1 EP3333523 A1 EP 3333523A1 EP 16202437 A EP16202437 A EP 16202437A EP 3333523 A1 EP3333523 A1 EP 3333523A1
- Authority
- EP
- European Patent Office
- Prior art keywords
- plug
- sealing body
- base body
- sealing
- container
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 238000004108 freeze drying Methods 0.000 title claims abstract description 25
- 238000007789 sealing Methods 0.000 claims abstract description 117
- 238000003780 insertion Methods 0.000 claims abstract description 41
- 230000037431 insertion Effects 0.000 claims abstract description 41
- 239000000463 material Substances 0.000 claims abstract description 35
- 230000004888 barrier function Effects 0.000 claims description 18
- 230000000903 blocking effect Effects 0.000 claims description 16
- 238000001746 injection moulding Methods 0.000 claims description 14
- 239000004743 Polypropylene Substances 0.000 claims description 6
- 229920001155 polypropylene Polymers 0.000 claims description 6
- 229920001903 high density polyethylene Polymers 0.000 claims description 4
- 239000004700 high-density polyethylene Substances 0.000 claims description 4
- -1 polypropylene Polymers 0.000 claims description 4
- 229920002725 thermoplastic elastomer Polymers 0.000 claims description 4
- 238000000034 method Methods 0.000 description 13
- 239000000243 solution Substances 0.000 description 9
- 239000000126 substance Substances 0.000 description 8
- 239000007789 gas Substances 0.000 description 7
- 238000004519 manufacturing process Methods 0.000 description 7
- 230000000694 effects Effects 0.000 description 5
- 230000015572 biosynthetic process Effects 0.000 description 4
- 238000009792 diffusion process Methods 0.000 description 4
- XAGFODPZIPBFFR-UHFFFAOYSA-N aluminium Chemical compound [Al] XAGFODPZIPBFFR-UHFFFAOYSA-N 0.000 description 3
- 229910052782 aluminium Inorganic materials 0.000 description 3
- QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical compound [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 description 3
- 229920005549 butyl rubber Polymers 0.000 description 3
- 238000011161 development Methods 0.000 description 3
- 230000018109 developmental process Effects 0.000 description 3
- 229920001971 elastomer Polymers 0.000 description 3
- 239000001301 oxygen Substances 0.000 description 3
- 229910052760 oxygen Inorganic materials 0.000 description 3
- 238000011109 contamination Methods 0.000 description 2
- 239000011521 glass Substances 0.000 description 2
- 239000004615 ingredient Substances 0.000 description 2
- 239000002904 solvent Substances 0.000 description 2
- 208000031872 Body Remains Diseases 0.000 description 1
- 229920000219 Ethylene vinyl alcohol Polymers 0.000 description 1
- 230000002411 adverse Effects 0.000 description 1
- 239000012080 ambient air Substances 0.000 description 1
- 238000004458 analytical method Methods 0.000 description 1
- 239000007864 aqueous solution Substances 0.000 description 1
- 239000011324 bead Substances 0.000 description 1
- 229920005557 bromobutyl Polymers 0.000 description 1
- 229920005556 chlorobutyl Polymers 0.000 description 1
- 239000012611 container material Substances 0.000 description 1
- 229920001577 copolymer Polymers 0.000 description 1
- 239000003814 drug Substances 0.000 description 1
- 229940079593 drug Drugs 0.000 description 1
- 238000005265 energy consumption Methods 0.000 description 1
- 238000005516 engineering process Methods 0.000 description 1
- 239000004744 fabric Substances 0.000 description 1
- 239000011888 foil Substances 0.000 description 1
- 239000003292 glue Substances 0.000 description 1
- 239000000203 mixture Substances 0.000 description 1
- 239000004033 plastic Substances 0.000 description 1
- 229920003023 plastic Polymers 0.000 description 1
- 239000007779 soft material Substances 0.000 description 1
- 239000011343 solid material Substances 0.000 description 1
- 238000004073 vulcanization Methods 0.000 description 1
Images
Classifications
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B65—CONVEYING; PACKING; STORING; HANDLING THIN OR FILAMENTARY MATERIAL
- B65D—CONTAINERS FOR STORAGE OR TRANSPORT OF ARTICLES OR MATERIALS, e.g. BAGS, BARRELS, BOTTLES, BOXES, CANS, CARTONS, CRATES, DRUMS, JARS, TANKS, HOPPERS, FORWARDING CONTAINERS; ACCESSORIES, CLOSURES, OR FITTINGS THEREFOR; PACKAGING ELEMENTS; PACKAGES
- B65D39/00—Closures arranged within necks or pouring openings or in discharge apertures, e.g. stoppers
- B65D39/0052—Closures arranged within necks or pouring openings or in discharge apertures, e.g. stoppers made in more than one piece
- B65D39/0076—Plastic closures other than those covered by groups B65D39/0058 - B65D39/007
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B65—CONVEYING; PACKING; STORING; HANDLING THIN OR FILAMENTARY MATERIAL
- B65D—CONTAINERS FOR STORAGE OR TRANSPORT OF ARTICLES OR MATERIALS, e.g. BAGS, BARRELS, BOTTLES, BOXES, CANS, CARTONS, CRATES, DRUMS, JARS, TANKS, HOPPERS, FORWARDING CONTAINERS; ACCESSORIES, CLOSURES, OR FITTINGS THEREFOR; PACKAGING ELEMENTS; PACKAGES
- B65D39/00—Closures arranged within necks or pouring openings or in discharge apertures, e.g. stoppers
- B65D39/0052—Closures arranged within necks or pouring openings or in discharge apertures, e.g. stoppers made in more than one piece
- B65D39/0094—Glass, ceramic or metal stoppers for perfume bottles or the like
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B65—CONVEYING; PACKING; STORING; HANDLING THIN OR FILAMENTARY MATERIAL
- B65D—CONTAINERS FOR STORAGE OR TRANSPORT OF ARTICLES OR MATERIALS, e.g. BAGS, BARRELS, BOTTLES, BOXES, CANS, CARTONS, CRATES, DRUMS, JARS, TANKS, HOPPERS, FORWARDING CONTAINERS; ACCESSORIES, CLOSURES, OR FITTINGS THEREFOR; PACKAGING ELEMENTS; PACKAGES
- B65D2539/00—Details relating to closures arranged within necks or pouring openings or in discharge apertures, e.g. stoppers
- B65D2539/001—Details of closures arranged within necks or pouring opening or in discharge apertures, e.g. stoppers
- B65D2539/008—Details of closures arranged within necks or pouring opening or in discharge apertures, e.g. stoppers with coatings or coverings
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B65—CONVEYING; PACKING; STORING; HANDLING THIN OR FILAMENTARY MATERIAL
- B65D—CONTAINERS FOR STORAGE OR TRANSPORT OF ARTICLES OR MATERIALS, e.g. BAGS, BARRELS, BOTTLES, BOXES, CANS, CARTONS, CRATES, DRUMS, JARS, TANKS, HOPPERS, FORWARDING CONTAINERS; ACCESSORIES, CLOSURES, OR FITTINGS THEREFOR; PACKAGING ELEMENTS; PACKAGES
- B65D51/00—Closures not otherwise provided for
- B65D51/002—Closures to be pierced by an extracting-device for the contents and fixed on the container by separate retaining means
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B65—CONVEYING; PACKING; STORING; HANDLING THIN OR FILAMENTARY MATERIAL
- B65D—CONTAINERS FOR STORAGE OR TRANSPORT OF ARTICLES OR MATERIALS, e.g. BAGS, BARRELS, BOTTLES, BOXES, CANS, CARTONS, CRATES, DRUMS, JARS, TANKS, HOPPERS, FORWARDING CONTAINERS; ACCESSORIES, CLOSURES, OR FITTINGS THEREFOR; PACKAGING ELEMENTS; PACKAGES
- B65D51/00—Closures not otherwise provided for
- B65D51/24—Closures not otherwise provided for combined or co-operating with auxiliary devices for non-closing purposes
- B65D51/241—Closures not otherwise provided for combined or co-operating with auxiliary devices for non-closing purposes provided with freeze-drying means
-
- F—MECHANICAL ENGINEERING; LIGHTING; HEATING; WEAPONS; BLASTING
- F26—DRYING
- F26B—DRYING SOLID MATERIALS OR OBJECTS BY REMOVING LIQUID THEREFROM
- F26B5/00—Drying solid materials or objects by processes not involving the application of heat
- F26B5/04—Drying solid materials or objects by processes not involving the application of heat by evaporation or sublimation of moisture under reduced pressure, e.g. in a vacuum
- F26B5/06—Drying solid materials or objects by processes not involving the application of heat by evaporation or sublimation of moisture under reduced pressure, e.g. in a vacuum the process involving freezing
Definitions
- the invention relates to a plug for a container for use in freeze-drying, also referred to as lyophilization.
- a solution with appropriate ingredients is first prepared and this solution then dried in a freeze dryer.
- the solution is an aqueous solution.
- the solution is first filled into a container, for example a glass cuvette or glass bottle.
- a plug is usually inserted into the container in order to completely close it for freeze-drying or after freeze-drying.
- the plug is designed such that the freeze-drying process, a gas exchange between the container interior and the environment is possible. This can be achieved, for example, in that the plug in the process of Freeze-drying is only partially inserted into the container, and thus the container is not yet sealed. In this way, during the freeze-drying process, the solvent may be removed from the solution to dry the ingredients of the solution. Following the freeze-drying process, the plug is typically pushed further into the container with the aid of a device formed in the lyophilizer, so that the bottle is then sealed tightly thereafter. Often, a fuse closure is then attached to the container to secure the plug. This securing closure may be, for example, a crimp cap or a screw cap.
- a plug for use in a freeze-drying process is known, for example, from the document DE 20 2011 050 413 U1 known.
- the piston plug has an upper side and a lower side, with the lower side facing the upper side in an axial direction.
- the piston plug has, in the area of the underside, at least one outwardly open, open cavity for gas exchange during freeze-drying, which is open in an axial direction downwards and in a radial direction.
- the stoppers currently used in the field of freeze-drying also referred to as lyophilization stoppers or freeze-drying stoppers, are generally produced from a butyl rubber, also referred to as butyl rubber, for example bromobutyl rubber or chlorobutyl rubber.
- a butyl rubber also referred to as butyl rubber
- bromobutyl rubber or chlorobutyl rubber for example bromobutyl rubber or chlorobutyl rubber.
- freeze-drying stoppers are known, which are formed in two parts, wherein the two parts of the plug are made of different materials.
- a plug having the features of the preamble of claim 1 is known from the document DE 1 942 347 A known.
- the plug has an insertable into the container insertable portion, wherein the insertion portion has a side surface and a bottom surface, wherein the bottom surface of a top surface the plug is formed opposite in an axial direction of the plug.
- the insertion section in turn has a sealing portion and a contact portion, wherein the abutment portion has a passage opening for a gas exchange, said passage opening extending from the side surface in the bottom surface.
- the stopper on a sealing body and a base body, which are interconnected.
- the sealing body is formed by an upper part of the plug and the base body is formed by a lower part of the plug, wherein the upper part consists of a different material than the lower part.
- the object of the present invention is to develop a plug having the features of the preamble of patent claim 1 in such a way that the plug nevertheless has a particularly good sealing property and / or barrier property and / or chemical resistance with lower material costs and lower production costs.
- the plug should be designed so that can be dispensed with a use of butyl rubber and thus on a vulcanization of the plug.
- the invention proposes a plug, which is formed according to the features of claim 1.
- the plug according to the invention is designed such that outer surfaces of the sealing body form the side surface and the bottom surface of the insertion section. Furthermore, the base body is formed in the region of the insertion section within the sealing body, wherein the base body consists of a material which has a higher hardness than a material of which the sealing body consists.
- a wall thickness of the sealing body and the base body relative to the total extent of the plug is reduced.
- the reduction of the wall thickness of the sealing body by the formation of the base body within the sealing body leads to a reduction of the material requirement for the sealing body, whereby the manufacturing costs are reduced, as for the base body can be used in comparison to the material of the sealing body more cost-effective material.
- the sealing body which comes into contact with the container and the contents of the container may be made of a material each having the desired material properties, for example the necessary elasticity, chemical resistance and / or barrier property to that in the substance stored in the container or the substances stored in the container and / or the solvent used in the solution. Also, contamination of the contents of the container by substances from the environment, such as oxygen, can be avoided or at least reduced by an appropriate choice of material.
- the base body can be made of a less expensive material, for example polypropylene (PP).
- PP polypropylene
- the plug is stiffened in the interior of the sealing portion, whereby the sealing effect of the plug despite reducing the wall thickness of the sealing body against a stopper which consists of a solid material in the region of the sealing portion, is approximately equal or even increased.
- the barrier property of the plug can be adjusted by adapting the material of the basic body.
- the formation of the plug with a formed inside the sealing body body made of a harder material also with regard to a manufacturing process of the plug to be considered advantageous.
- material of the sealing body and the base of the plug by means of a multi-component injection molding process, in particular by means of a two-component injection molding process can be produced by the harder against the sealing body a ejector during removal from an injection molding tool not exclusively in soft material which facilitates demolding and avoids damaging the plug in the demoulding process.
- the blocking effect of the plug to be stored in the container materials and / or the ambient atmosphere can be adjusted in a simple manner.
- the sealing body and the base body are connected directly to each other. It is therefore not intended to glue these together.
- the sealing body and the base body are connected to one another directly by material engagement.
- These direct, in particular direct cohesive connection between the sealing body and the main body these are inextricably linked, whereby the plug is quasi one piece. Due to the quasi-one-piece design of the plug, the use of the plug, in particular with regard to an automated freeze-drying method in which the mechanical insertion of the plug is automated, is facilitated.
- the sealing body from the body dissolves and example, the sealing body remains in the process of opening the container in the container or it during insertion of the Stopfens by a relative movement of the sealing body to the base body to a bead formation on the sealing body comes, which adversely affects the sealing effect of the plug.
- the cohesive connection preferably takes place without an additional method step in that the sealing body is injection-molded onto the base body or the base body is injection-molded onto the sealing body by means of an injection molding method.
- the sealing body has a circular cross-section in the region of the sealing section.
- a ratio of an outer radius of the annulus to an inner radius of the annulus is 1.1 to 2.5.
- the plug has a blocking body or a barrier layer.
- a blocking body or a barrier layer By means of the blocking body or the barrier layer, for example, a diffusion of oxygen through the stopper into the interior of the container can be prevented or at least reduced.
- the material of the blocking body or the barrier layer may be, for example, a plastic, for example vinyl alcohol copolymer (EVOH), or aluminum, in particular an aluminum foil.
- the barrier layer and / or the blocking body forms the top surface.
- the blocking body and / or the barrier layer is preferably formed between the main body and the sealing body. As a result, the barrier layer or the blocking body is particularly well protected against damage from external forces.
- the blocking body or the barrier layer is materially connected to the base body and / or materially connected to the sealing body.
- an outer surface of the base body forms the top surface of the plug, wherein the top surface covers the sealing body in the axial direction.
- the stopper has a cover section adjoining the insertion section in the axial direction, the cover section having the cover surface and wherein a radial dimension of the cover section is at least as great, in particular larger, than the radial dimension of the introductory section.
- the embodiment of the cover section with a larger radial dimension is to be regarded as advantageous in that is limited by the cover the insertion depth of the plug into the container.
- an outer surface of the sealing body forms a bearing surface of the cover section facing away from the cover surface. This bearing surface comes into contact with the outer surface of the container during insertion of the stopper into the container, whereby this bearing surface contributes to the sealing effect of the stopper.
- the base body in the region of the cover portion has a first projection formed in the radial direction, wherein the first projection is designed in particular as a circumferential first projection.
- This projection may serve to hold the plug in an additional closure attachable to the container.
- This closure may be, for example, a crimp cap or a screw cap.
- an additional closure is attached to the container following the freeze-drying process to secure the plug. It is quite conceivable that the complete insertion of the plug into the container takes place by attaching the closure to the container.
- the holding of the plug in the closure can be effected, for example, by a partial region of the closure having the first projection on the container engages behind facing, for example, the first projection is disposed in an undercut of the closure.
- the connection between the closure and the plug ensures that the plug is pulled out of the container when the closure is removed from the container, for example when unscrewing a closure designed as a rotary closure.
- the base body in an advantageous embodiment of the plug covers the sealing body in the region of the cover radially outward at least partially.
- the base body in the area of the cover section, has a second projection formed radially on the outside, extending from the cover surface in the direction of the bottom surface, the second projection at least partially covering the sealing element radially outside in the region of the cover section.
- the sealing body is radially enclosed by the second projection.
- a partial region of the sealing body extending from the bottom surface in the direction of the top surface is radially enclosed by the base body.
- the base body has a through channel extending from the top surface in the direction of the bottom surface.
- This passage allows, for example, by means of a syringe or the like to remove contents from the container without removing the plug from the container.
- a needle or the like can be introduced into the through-channel, whereby the bottom surface of the sealing body is pierced in the region adjacent to the through-channel and thus the contents of the container become accessible.
- a partial region of the sealing body extending from the bottom surface in the direction of the top surface is formed in the through-channel.
- the design of the base body with a passage is also to be regarded as advantageous with respect to a production of the plug by injection molding.
- a main body can be injection-molded with a through-channel and subsequently the sealing body can be injection-molded from the side facing the top surface through the through-channel to the main body.
- the through-channel is formed centrally in the base body, whereby shape tolerances, in particular with regard to the roundness of the sealing body, can be reduced.
- the sealing body has a recess, wherein the recess forms the passage opening for the gas exchange.
- the sealing body consists of a material having a hardness of Shore A 40 to 80, preferably a hardness of Shore A 50 to 70, according to the standard DIN ISO 7619-1: 2010 and / or the sealing body of a thermoplastic elastomer (TPE) exists.
- TPE thermoplastic elastomer
- the base body consists of a material which has a hardness of Shore D 30 to 100, preferably a hardness of Shore D 40 to 85 according to DIN ISO 7619-1: 2010 and / / or the base body is made of polypropylene (PP) or high-density polyethylene (HDPE).
- PP polypropylene
- HDPE high-density polyethylene
- the base body and / or the sealing body and / or the plug is symmetrical, in particular radially symmetrical, to an axis of symmetry and / or plane of symmetry running in the axial direction.
- the plug is a plug made by a multi-component injection molding process, preferably by a two-component or a three-component injection molding process.
- Fig. 1 and 2 illustrate the upper end of a container 18 and a first embodiment of a plug 1 for use in a freeze-drying process.
- FIG. 1 an arrangement of the container 18 and the plug 1 is shown, in which an insertion portion 2 of the plug 1 is partially inserted in a neck 19 of the container 18.
- the Fig. 2 shows an arrangement of the container 18 and the plug 1, in which the insertion portion 2 of the plug 1 is fully inserted into the container neck 19 of the container 18 and a cover portion 10 of the plug 1 abuts an outer surface 20 of the container neck 19.
- the insertion section 2 has a side surface 3 and a bottom surface 4, the bottom surface 4 of a cover surface 5 formed in the region of the cover 10 of the plug 1 in an axial direction Z of the plug 1 is formed opposite.
- the insertion section 2 has a sealing section 16 and a contact section 17 on, wherein the abutment portion 17 has four passage openings 6 for a gas exchange, wherein the passage openings 6 are identical and each formed in the form of a recess 6.
- the respective recess 6 extends from the side surface 3 in the bottom surface 4 and thus allows in a state in which the insertion section 2 of the plug 1 is only partially inserted into the container 18, a gas exchange between the interior of the container 18 and the environment. This condition is in the Fig.
- abutment portion 17 of the plug 1 is partially formed outside the container neck 19, wherein the located outside of the container 18 portion of the abutment portion 17 has a in a radial direction Y open portion of the respective passage opening 6 and in this way a gas exchange between the container interior and the environment is possible. Consequently, in this, in the Fig. 1 state shown a freeze-drying of a stored in the container 18 solution possible.
- the plug 1 has a sealing portion 16 adjacent to the abutment portion 17 in the direction of the top surface 5, the sealing portion 16 abutting the inner surface 21 of the container neck 19 in a state in which the insertion portion 2 is fully inserted into the container 18 thus sealing the container 18 sealing.
- the plug 1 As in particular the sectional view of Fig. 6 can be seen, the plug 1, a sealing body 7 and a base body 8, wherein outer surfaces of the sealing body 7, the side surface 3 and the bottom surface 4 of the insertion section 2 form.
- the main body 8 is formed in the region of the insertion section 2 within the sealing body 7, whereby only the sealing body 7 comes into contact with the inner surface 21 of the container 18 and the interior of the container 18.
- the sealing body 7 and the base body 8 are materially connected to each other. Due to the cohesive connection of the sealing body 7 and the base body 8 are permanently connected to each other, so that the plug 1 is formed quasi one piece.
- the cohesive connection is preferably produced by a multi-component injection molding process, in particular a two-component injection molding process.
- the main body 8 and the sealing body 7 are made of different materials, wherein the base body 8 consists of a material which has a higher hardness than a material of which the sealing body 7 consists.
- the sealing body 7 has in the region of the sealing portion 16 has a circular cross-section, wherein an outer radius R of the annulus is approximately twice an inner radius r of the annulus.
- the sealing body 7 and the main body 8 are partially formed in the cover portion 10, wherein an outer surface of the base body 8 forms the top surface 5 and the top surface 5, the sealing body 7 in the axial direction Z covers.
- the cover portion 10 has a radial dimension which is greater than a radial dimension of the insertion section 2.
- support surface 11 of the cover 10 is located on the outer surface 20 of the container 18 at. This support surface 11 of the cover 10 is formed by an outer surface of the sealing body 7.
- Both the base body 8 and the sealing body 7 of the plug 1 are formed radially symmetrical to an axis of symmetry 18 of the plug 1 extending in the axial direction Z.
- the main body 8 is cylindrical both in the region of the insertion section 2 and substantially cylindrical in the region of the cover section 10, wherein the main body 8 in the region of the cover section 10 has a larger diameter than in the region of the insertion section 2.
- the main body 8 has a circumferential first projection 12 formed in the radial direction.
- This first projection 12 may, for example, serve to hold the plug 1 in an additional closure attachable to the container 18.
- the base body 8 covers in the in the 8 to 11 shown second embodiment of the plug 1, the sealing body 7 in the region of the cover portion 10 radially on the outside partially.
- the base body 8 in the region of the cover 10 has a radially outwardly extending, extending from the top surface 5 in the direction of the bottom surface 4 second projection 13, wherein the second projection 13, the sealing body 7 in the region of the cover 10 radially outward partially covering.
- the plug 1 differs from that in the Fig. 8 and 9 embodiment shown essentially in that the plug 1 has formed between the base body 8 and the sealing body 7 blocking body 9 in the form of a barrier layer 9 in order to improve the blocking effect of the plug 1, for example against oxygen diffusion.
- the barrier layer 9 and / or the blocking body 9 may for example consist of ethylene-vinyl alcohol copolymer (EVOH) or aluminum.
- EVOH ethylene-vinyl alcohol copolymer
- the locking body 9 and / or the barrier layer 9 is materially connected to the base body 8 and / or materially connected to the sealing body 7.
- Such a plug 1 can be produced for example by means of a three-component injection molding process. But it is also quite conceivable that the blocking body 9 and / or the barrier layer 9 between the base body 8 and the sealing body 7 is clamped or positively held.
- the base body 8 has a extending from the top surface 5 in the direction of the bottom surface 4, the central passageway 15, wherein a from the bottom surface 4 in the direction of the top surface 5 extending portion 14 of the sealing body 7 is formed in the passage 15, whereby the base 8 surrounds this portion 14 of the sealing body 7 radially.
- the passageway 15 allows removal of the contents of the container without removal of the plug 1 from the container 18, for example, by inserting a needle into the passage 15 and the sealing body 7 is pierced in the insertion of the needle.
- such an embodiment of the plug 1 is particularly simple and inexpensive to produce by first the main body 8, for example by means of an injection molding process is prepared and then the sealing body 7 is molded onto the base body 8, wherein the injection molding of the sealing body 7 through the passage 15 of the main body 8 takes place. Due to the centrally formed passage 15 and thus the central gating of the sealing body 7 to the main body 8 also shape tolerances of the plug 1 are reduced.
- the exemplary embodiments of the plug 1 illustrated in the figures have a conical outer contour in a region of the contact section 17 which has the bottom surface 4.
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- Engineering & Computer Science (AREA)
- Mechanical Engineering (AREA)
- Chemical & Material Sciences (AREA)
- Ceramic Engineering (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Molecular Biology (AREA)
- General Engineering & Computer Science (AREA)
- Closures For Containers (AREA)
Priority Applications (4)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
EP16202437.6A EP3333523B1 (fr) | 2016-12-06 | 2016-12-06 | Bouchon de récipient destiné à être utilisé lors de la lyophilisation |
PCT/EP2017/074314 WO2018103906A1 (fr) | 2016-12-06 | 2017-09-26 | Bouchon pour un récipient destiné à être utilisé lors de la cryodessiccation et arrangement d'un bouchon et d'un récipient |
EP17769107.8A EP3384219B1 (fr) | 2016-12-06 | 2017-09-26 | Bouchon de récipient destiné à être utilisé lors de la lyophilisation |
US16/466,466 US11434050B2 (en) | 2016-12-06 | 2017-09-26 | Stopper for a container for use in freeze-drying processes, and assembly of a stopper and a container |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
EP16202437.6A EP3333523B1 (fr) | 2016-12-06 | 2016-12-06 | Bouchon de récipient destiné à être utilisé lors de la lyophilisation |
Publications (2)
Publication Number | Publication Date |
---|---|
EP3333523A1 true EP3333523A1 (fr) | 2018-06-13 |
EP3333523B1 EP3333523B1 (fr) | 2019-09-04 |
Family
ID=57530510
Family Applications (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
EP16202437.6A Active EP3333523B1 (fr) | 2016-12-06 | 2016-12-06 | Bouchon de récipient destiné à être utilisé lors de la lyophilisation |
EP17769107.8A Active EP3384219B1 (fr) | 2016-12-06 | 2017-09-26 | Bouchon de récipient destiné à être utilisé lors de la lyophilisation |
Family Applications After (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
EP17769107.8A Active EP3384219B1 (fr) | 2016-12-06 | 2017-09-26 | Bouchon de récipient destiné à être utilisé lors de la lyophilisation |
Country Status (3)
Country | Link |
---|---|
US (1) | US11434050B2 (fr) |
EP (2) | EP3333523B1 (fr) |
WO (1) | WO2018103906A1 (fr) |
Families Citing this family (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP3333523B1 (fr) | 2016-12-06 | 2019-09-04 | KISIKO Kirchner, Simon & Co. GmbH | Bouchon de récipient destiné à être utilisé lors de la lyophilisation |
US11345505B2 (en) * | 2020-08-19 | 2022-05-31 | Innovative Distilling Technologies, Inc. | Capped barrel system and methods |
US11957790B1 (en) | 2022-01-31 | 2024-04-16 | Thomas John Harkins, JR. | Combination lyophilization and dispensing syringe assembly and methods of using same |
US20240083645A1 (en) * | 2023-08-02 | 2024-03-14 | Huacheng Li | Container sealing plug and container |
Citations (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
FR1479255A (fr) * | 1965-11-25 | 1967-05-05 | Bouchon pour récipients tels que flacons ou analogues | |
DE1942347A1 (de) | 1969-08-20 | 1971-03-04 | Wimmer Pharma Gummi Gmbh | Stopfen fuer Flaschen,bei denen eine Gefriertrocknung vorgenommen wird |
US4306357A (en) * | 1978-06-05 | 1981-12-22 | Merck & Co., Inc. | Tamperproof container |
US5596814A (en) * | 1995-11-06 | 1997-01-28 | W. L. Gore & Associates, Inc. | Vented vial stopper for processing freeze-dried products |
US5689895A (en) * | 1996-10-31 | 1997-11-25 | S.P. Industries, Inc., The Virtis Division | Probe positioning device for a flask freeze drying |
DE202011050413U1 (de) | 2011-06-10 | 2012-09-11 | Helvoet Pharma Belgium N.V. | Kolbenstopfen für eine Lyophilisations-Einheit |
Family Cites Families (11)
Publication number | Priority date | Publication date | Assignee | Title |
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US2889951A (en) * | 1954-10-22 | 1959-06-09 | Bunder Glas G M B H | Bottle closures |
US2820564A (en) * | 1956-06-11 | 1958-01-21 | Coty Inc | Bottle neck stoppers |
US2927709A (en) * | 1959-07-07 | 1960-03-08 | Faultless Rubber Co | Bottle stopple |
US3292342A (en) * | 1964-01-16 | 1966-12-20 | Copiague Res And Dev Company | Device for vacuum sealing |
US4040421A (en) * | 1975-04-04 | 1977-08-09 | Becton, Dickinson And Company | Hypodermic syringe and attached needle assembly |
DE3736343C2 (de) | 1987-10-27 | 1996-07-18 | Wasserburger Arzneimittelwerk | Injektionsspritze |
CA2006584C (fr) * | 1988-12-27 | 1998-11-10 | Gabriel Meyer | Flacon de stockage et de transfert pour stocker un composant d'une substance medicamenteuse |
US5377854A (en) * | 1993-04-16 | 1995-01-03 | International Technidyne Corp. | Stopper apparatus for a test tube or similar article |
JPH1147234A (ja) * | 1997-07-29 | 1999-02-23 | Naniwa Rubber Kogyo Kk | 医療用ゴム栓 |
US9199768B1 (en) * | 2015-02-11 | 2015-12-01 | Ryan M. Casey | Two-piece stopper |
EP3333523B1 (fr) | 2016-12-06 | 2019-09-04 | KISIKO Kirchner, Simon & Co. GmbH | Bouchon de récipient destiné à être utilisé lors de la lyophilisation |
-
2016
- 2016-12-06 EP EP16202437.6A patent/EP3333523B1/fr active Active
-
2017
- 2017-09-26 EP EP17769107.8A patent/EP3384219B1/fr active Active
- 2017-09-26 WO PCT/EP2017/074314 patent/WO2018103906A1/fr active Application Filing
- 2017-09-26 US US16/466,466 patent/US11434050B2/en active Active
Patent Citations (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
FR1479255A (fr) * | 1965-11-25 | 1967-05-05 | Bouchon pour récipients tels que flacons ou analogues | |
DE1942347A1 (de) | 1969-08-20 | 1971-03-04 | Wimmer Pharma Gummi Gmbh | Stopfen fuer Flaschen,bei denen eine Gefriertrocknung vorgenommen wird |
US4306357A (en) * | 1978-06-05 | 1981-12-22 | Merck & Co., Inc. | Tamperproof container |
US5596814A (en) * | 1995-11-06 | 1997-01-28 | W. L. Gore & Associates, Inc. | Vented vial stopper for processing freeze-dried products |
US5689895A (en) * | 1996-10-31 | 1997-11-25 | S.P. Industries, Inc., The Virtis Division | Probe positioning device for a flask freeze drying |
DE202011050413U1 (de) | 2011-06-10 | 2012-09-11 | Helvoet Pharma Belgium N.V. | Kolbenstopfen für eine Lyophilisations-Einheit |
Also Published As
Publication number | Publication date |
---|---|
WO2018103906A1 (fr) | 2018-06-14 |
US11434050B2 (en) | 2022-09-06 |
EP3333523B1 (fr) | 2019-09-04 |
US20190389630A1 (en) | 2019-12-26 |
EP3384219A1 (fr) | 2018-10-10 |
EP3384219B1 (fr) | 2020-11-18 |
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