EP3333523A1 - Stopper for a container for use in freeze drying - Google Patents

Abstract

The invention relates to a plug (1) for a container for use in freeze-drying, also referred to as lyophilization. The stopper (1) has an insertion section (2) insertable into the container, the insertion section (2) having a side surface (3) and a bottom surface (4), the bottom surface (4) being a top surface (5) of the stopper (5). 1) in an axial direction (Z) of the plug (1) is formed opposite. The insertion section (2) in turn has a sealing section (16) and a contact section (17), wherein the contact section (17) has a passage opening (6) for a gas exchange, said passage opening (6) from the side surface (3) the bottom surface (4) extends. The plug (1) has a sealing body (7), wherein outer surfaces of the sealing body (7) form the side surface (3) and the bottom surface (4) of the insertable into the container insertion section (2). Furthermore, the plug (1) has a base body (8), wherein the base body (8) is formed in the region of the insertion section (2) within the sealing body (7). The base body (8) and the sealing body (7) are interconnected. The base body (8) consists of a material which has a higher hardness than a material of which the sealing body (7) consists.

Description

The invention relates to a plug for a container for use in freeze-drying, also referred to as lyophilization.

In a method for producing a freeze-dried product, as is often used in the field of medical diagnostics, chemical analysis, food and / or pharmaceutical industry, for example, to produce diagnostics and / or drugs, a solution with appropriate ingredients is first prepared and this solution then dried in a freeze dryer. Typically, the solution is an aqueous solution. Usually, the solution is first filled into a container, for example a glass cuvette or glass bottle. In order to prevent contamination of the solution or of the container interior during the process of freeze-drying and / or following freeze-drying, a plug is usually inserted into the container in order to completely close it for freeze-drying or after freeze-drying.

The plug is designed such that the freeze-drying process, a gas exchange between the container interior and the environment is possible. This can be achieved, for example, in that the plug in the process of Freeze-drying is only partially inserted into the container, and thus the container is not yet sealed. In this way, during the freeze-drying process, the solvent may be removed from the solution to dry the ingredients of the solution. Following the freeze-drying process, the plug is typically pushed further into the container with the aid of a device formed in the lyophilizer, so that the bottle is then sealed tightly thereafter. Often, a fuse closure is then attached to the container to secure the plug. This securing closure may be, for example, a crimp cap or a screw cap.

A plug for use in a freeze-drying process is known, for example, from the document DE 20 2011 050 413 U1 known. The piston plug has an upper side and a lower side, with the lower side facing the upper side in an axial direction. The piston plug has, in the area of the underside, at least one outwardly open, open cavity for gas exchange during freeze-drying, which is open in an axial direction downwards and in a radial direction.

The stoppers currently used in the field of freeze-drying, also referred to as lyophilization stoppers or freeze-drying stoppers, are generally produced from a butyl rubber, also referred to as butyl rubber, for example bromobutyl rubber or chlorobutyl rubber. The production of the plug as a rubber molded part is relatively expensive, since on the one hand, the material costs are relatively high and also must vulcanize the rubber mixture in a heated mold, whereby the cycle times and the energy consumption during production are relatively high.

There are also freeze-drying stoppers are known, which are formed in two parts, wherein the two parts of the plug are made of different materials. Such a plug having the features of the preamble of claim 1 is known from the document DE 1 942 347 A known. The plug has an insertable into the container insertable portion, wherein the insertion portion has a side surface and a bottom surface, wherein the bottom surface of a top surface the plug is formed opposite in an axial direction of the plug. The insertion section in turn has a sealing portion and a contact portion, wherein the abutment portion has a passage opening for a gas exchange, said passage opening extending from the side surface in the bottom surface. Furthermore, the stopper on a sealing body and a base body, which are interconnected.

In the plug according to the aforementioned document, the sealing body is formed by an upper part of the plug and the base body is formed by a lower part of the plug, wherein the upper part consists of a different material than the lower part.

The object of the present invention is to develop a plug having the features of the preamble of patent claim 1 in such a way that the plug nevertheless has a particularly good sealing property and / or barrier property and / or chemical resistance with lower material costs and lower production costs. In particular, according to developments of the plug should be designed so that can be dispensed with a use of butyl rubber and thus on a vulcanization of the plug.

To achieve the above object, the invention proposes a plug, which is formed according to the features of claim 1.

The plug according to the invention is designed such that outer surfaces of the sealing body form the side surface and the bottom surface of the insertion section. Furthermore, the base body is formed in the region of the insertion section within the sealing body, wherein the base body consists of a material which has a higher hardness than a material of which the sealing body consists.

By this design of the plug, a wall thickness of the sealing body and the base body relative to the total extent of the plug is reduced. In particular, the reduction of the wall thickness of the sealing body by the formation of the base body within the sealing body, leads to a reduction of the material requirement for the sealing body, whereby the manufacturing costs are reduced, as for the base body can be used in comparison to the material of the sealing body more cost-effective material.

In such a plug formation, the sealing body which comes into contact with the container and the contents of the container may be made of a material each having the desired material properties, for example the necessary elasticity, chemical resistance and / or barrier property to that in the substance stored in the container or the substances stored in the container and / or the solvent used in the solution. Also, contamination of the contents of the container by substances from the environment, such as oxygen, can be avoided or at least reduced by an appropriate choice of material.

In contrast, the base body can be made of a less expensive material, for example polypropylene (PP). By means of the body arranged in the sealing body, the plug is stiffened in the interior of the sealing portion, whereby the sealing effect of the plug despite reducing the wall thickness of the sealing body against a stopper which consists of a solid material in the region of the sealing portion, is approximately equal or even increased. In addition, the barrier property of the plug can be adjusted by adapting the material of the basic body.

Furthermore, the formation of the plug with a formed inside the sealing body body made of a harder material, also with regard to a manufacturing process of the plug to be considered advantageous. With appropriate choice of material of the sealing body and the base of the plug by means of a multi-component injection molding process, in particular by means of a two-component injection molding process can be produced by the harder against the sealing body a ejector during removal from an injection molding tool not exclusively in soft material which facilitates demolding and avoids damaging the plug in the demoulding process.

Furthermore, by a suitable choice of material combination of material of Sealing body and material of the body, the blocking effect of the plug to be stored in the container materials and / or the ambient atmosphere can be adjusted in a simple manner.

Preferably, the sealing body and the base body are connected directly to each other. It is therefore not intended to glue these together. In particular, the sealing body and the base body are connected to one another directly by material engagement. These direct, in particular direct cohesive connection between the sealing body and the main body these are inextricably linked, whereby the plug is quasi one piece. Due to the quasi-one-piece design of the plug, the use of the plug, in particular with regard to an automated freeze-drying method in which the mechanical insertion of the plug is automated, is facilitated. Due to the quasi one-piece design prevents that under mechanical loading of the plug, for example, to open or close the container, the sealing body from the body dissolves and example, the sealing body remains in the process of opening the container in the container or it during insertion of the Stopfens by a relative movement of the sealing body to the base body to a bead formation on the sealing body comes, which adversely affects the sealing effect of the plug.

It is also conceivable to weld the sealing body to the base body.

The cohesive connection preferably takes place without an additional method step in that the sealing body is injection-molded onto the base body or the base body is injection-molded onto the sealing body by means of an injection molding method.

In particular with regard to a reduction of the material of the sealing body with nevertheless good sealing property of the plug, it is considered to be particularly advantageous if the sealing body has a circular cross-section in the region of the sealing section. Preferably, a ratio of an outer radius of the annulus to an inner radius of the annulus is 1.1 to 2.5.

To the blocking effect of the plug relative to the stored in the container To improve fabrics and / or located outside of the container atmosphere is provided in a preferred embodiment of the plug, that the plug has a blocking body or a barrier layer. By means of the blocking body or the barrier layer, for example, a diffusion of oxygen through the stopper into the interior of the container can be prevented or at least reduced. The material of the blocking body or the barrier layer may be, for example, a plastic, for example vinyl alcohol copolymer (EVOH), or aluminum, in particular an aluminum foil.

It is quite conceivable that the barrier layer and / or the blocking body forms the top surface. However, the blocking body and / or the barrier layer is preferably formed between the main body and the sealing body. As a result, the barrier layer or the blocking body is particularly well protected against damage from external forces.

In this context, it is considered to be particularly advantageous if the blocking body or the barrier layer is materially connected to the base body and / or materially connected to the sealing body.

In a preferred embodiment of the plug, an outer surface of the base body forms the top surface of the plug, wherein the top surface covers the sealing body in the axial direction. As a result, on the one hand, the handling of the plug is facilitated by the opposite to the sealing body harder top surface and the other the effective outer surface of the plug, reduced because the surface of the sealing body, which comes into contact with the ambient air, reduced by the cover by means of the top surface of the body is, whereby a suitable choice of the material of the base body in combination with the choice of the material of the sealing body, a diffusion of substances from the environment into the container and / or a diffusion of substances from the container into the environment can be at least reduced.

It is considered to be particularly advantageous if the stopper has a cover section adjoining the insertion section in the axial direction, the cover section having the cover surface and wherein a radial dimension of the cover section is at least as great, in particular larger, than the radial dimension of the introductory section.

In particular, the embodiment of the cover section with a larger radial dimension is to be regarded as advantageous in that is limited by the cover the insertion depth of the plug into the container. During insertion of the plug with a cover section which is larger than the insertion section, the region of the cover section protruding from the insertion section comes into contact with an outer surface of the container facing the cover section, thereby preventing further insertion of the plug into the container.

Furthermore, removal of the plug from the container is facilitated by a cover section having a larger radial dimension, since the cover section forms an easily accessible engagement surface on the plug.

It is considered advantageous if an outer surface of the sealing body forms a bearing surface of the cover section facing away from the cover surface. This bearing surface comes into contact with the outer surface of the container during insertion of the stopper into the container, whereby this bearing surface contributes to the sealing effect of the stopper.

In a preferred embodiment of the plug, the base body in the region of the cover portion has a first projection formed in the radial direction, wherein the first projection is designed in particular as a circumferential first projection. This projection may serve to hold the plug in an additional closure attachable to the container. This closure may be, for example, a crimp cap or a screw cap. Typically, such an additional closure is attached to the container following the freeze-drying process to secure the plug. It is quite conceivable that the complete insertion of the plug into the container takes place by attaching the closure to the container.

The holding of the plug in the closure can be effected, for example, by a partial region of the closure having the first projection on the container engages behind facing, for example, the first projection is disposed in an undercut of the closure. The connection between the closure and the plug ensures that the plug is pulled out of the container when the closure is removed from the container, for example when unscrewing a closure designed as a rotary closure.

With regard to the connection between the plug and the closure, it is quite conceivable that the closure is already connected to the stopper before the process of freeze-drying.

In order to further reduce the effective outer surface of the plug, the base body in an advantageous embodiment of the plug covers the sealing body in the region of the cover radially outward at least partially. For this purpose, in a preferred embodiment, in the area of the cover section, the base body has a second projection formed radially on the outside, extending from the cover surface in the direction of the bottom surface, the second projection at least partially covering the sealing element radially outside in the region of the cover section. Preferably, the sealing body is radially enclosed by the second projection.

In an advantageous development of the plug, a partial region of the sealing body extending from the bottom surface in the direction of the top surface is radially enclosed by the base body. As a result, the contact surface between the sealing body and the base body is increased, which has an advantageous effect on the stability of the connection between them.

It is considered to be particularly advantageous if the base body has a through channel extending from the top surface in the direction of the bottom surface. This passage allows, for example, by means of a syringe or the like to remove contents from the container without removing the plug from the container. For this purpose, a needle or the like can be introduced into the through-channel, whereby the bottom surface of the sealing body is pierced in the region adjacent to the through-channel and thus the contents of the container become accessible.

It is entirely conceivable and preferred that a partial region of the sealing body extending from the bottom surface in the direction of the top surface is formed in the through-channel.

The design of the base body with a passage is also to be regarded as advantageous with respect to a production of the plug by injection molding. For example, first of all a main body can be injection-molded with a through-channel and subsequently the sealing body can be injection-molded from the side facing the top surface through the through-channel to the main body. This significantly simplifies the required tooling technology and makes the tool less expensive, more robust and more durable. It is considered to be particularly advantageous if the through-channel is formed centrally in the base body, whereby shape tolerances, in particular with regard to the roundness of the sealing body, can be reduced.

It is considered particularly advantageous if the sealing body has a recess, wherein the recess forms the passage opening for the gas exchange.

Preferably, the sealing body consists of a material having a hardness of Shore A 40 to 80, preferably a hardness of Shore A 50 to 70, according to the standard DIN ISO 7619-1: 2010 and / or the sealing body of a thermoplastic elastomer (TPE) exists.

With regard to the main body, it is considered particularly advantageous if the base body consists of a material which has a hardness of Shore D 30 to 100, preferably a hardness of Shore D 40 to 85 according to DIN ISO 7619-1: 2010 and / / or the base body is made of polypropylene (PP) or high-density polyethylene (HDPE).

In an advantageous development of the plug, the base body and / or the sealing body and / or the plug is symmetrical, in particular radially symmetrical, to an axis of symmetry and / or plane of symmetry running in the axial direction.

Preferably, the plug is a plug made by a multi-component injection molding process, preferably by a two-component or a three-component injection molding process.

Further features of the invention are set forth in the subclaims, the description of the figures and the figures themselves, wherein it is noted that all individual features and all combinations of individual features are essential to the invention.

In the figures, the invention is illustrated by means of embodiments, without being limited thereto.

Fig. 1

eine erste Ausführungsform eines Stopfens und einen Behälter in einer Anordnung, in der der Stopfen teilweise in den Behälter eingeführt ist, in einer Seitenansicht,

Fig. 2

der Stopfen und der Behälter gemäß Fig. 1 in einer Anordnung, in der der Stopfen maximal weit in den Behälter eingeführt ist, in einer Seitenansicht,

Fig. 3

der Stopfen gemäß Fig. 1 in einer Ansicht gemäß dem Pfeil III in Fig. 6,

Fig. 4

der Stopfen in einer Ansicht gemäß dem Pfeil IV in Fig. 3,

Fig. 5

der Stopfen in einer Ansicht gemäß dem Pfeil V in Fig. 3,

Fig. 6

der Stopfen in einer Schnittansicht gemäß der Linie VI-VI in Fig. 3,

Fig. 7

der Stopfen in einer Schnittansicht gemäß der Linie VII-VII in Fig. 3,

Fig. 8

eine zweite Ausführungsform des Stopfens in einer Ansicht gemäß dem Pfeil VIII in Fig. 9,

Fig. 9

der Stopfen in einer Schnittansicht gemäß der Linie IX-IX in Fig. 8,

Fig. 10

eine dritte Ausführungsform des Stopfens in einer Ansicht gemäß dem Pfeil X in Fig. 11,

Fig. 11

der Stopfen in einer Schnittansicht gemäß der Linie XI-XI in Fig. 10,

Fig. 12

eine vierte Ausführungsform des Stopfens in einer Ansicht gemäß dem Pfeil XII in Fig. 13,

Fig. 13

der Stopfen in einer Schnittansicht gemäß der Linie XIII-XIII in Fig. 12,

Fig. 14

der Stopfen in einer Ansicht gemäß dem Pfeil XIV in Fig. 13.

It shows:

Fig. 1

a first embodiment of a plug and a container in an arrangement in which the plug is partially inserted into the container, in a side view,

Fig. 2

the stopper and the container according to Fig. 1 in an arrangement in which the stopper is inserted maximally far into the container, in a side view,

Fig. 3

the plug according to Fig. 1 in a view according to the arrow III in Fig. 6 .

Fig. 4

the plug in a view according to the arrow IV in Fig. 3 .

Fig. 5

the plug in a view according to the arrow V in Fig. 3 .

Fig. 6

the plug in a sectional view along the line VI-VI in Fig. 3 .

Fig. 7

the plug in a sectional view along the line VII-VII in Fig. 3 .

Fig. 8

a second embodiment of the plug in a view according to the arrow VIII in Fig. 9 .

Fig. 9

the stopper in a sectional view along the line IX-IX in Fig. 8 .

Fig. 10

a third embodiment of the plug in a view according to the arrow X in Fig. 11 .

Fig. 11

the plug in a sectional view along the line XI-XI in Fig. 10 .

Fig. 12

a fourth embodiment of the plug in a view according to the arrow XII in Fig. 13 .

Fig. 13

the plug in a sectional view along the line XIII-XIII in Fig. 12 .

Fig. 14

the stopper in a view according to the arrow XIV in Fig. 13 ,

The Fig. 1 and 2 illustrate the upper end of a container 18 and a first embodiment of a plug 1 for use in a freeze-drying process.

In the Fig. 1 an arrangement of the container 18 and the plug 1 is shown, in which an insertion portion 2 of the plug 1 is partially inserted in a neck 19 of the container 18.

The Fig. 2 shows an arrangement of the container 18 and the plug 1, in which the insertion portion 2 of the plug 1 is fully inserted into the container neck 19 of the container 18 and a cover portion 10 of the plug 1 abuts an outer surface 20 of the container neck 19.

The insertion section 2 has a side surface 3 and a bottom surface 4, the bottom surface 4 of a cover surface 5 formed in the region of the cover 10 of the plug 1 in an axial direction Z of the plug 1 is formed opposite.

The insertion section 2 has a sealing section 16 and a contact section 17 on, wherein the abutment portion 17 has four passage openings 6 for a gas exchange, wherein the passage openings 6 are identical and each formed in the form of a recess 6. The respective recess 6 extends from the side surface 3 in the bottom surface 4 and thus allows in a state in which the insertion section 2 of the plug 1 is only partially inserted into the container 18, a gas exchange between the interior of the container 18 and the environment. This condition is in the Fig. 1 illustrated, wherein the abutment portion 17 of the plug 1 is partially formed outside the container neck 19, wherein the located outside of the container 18 portion of the abutment portion 17 has a in a radial direction Y open portion of the respective passage opening 6 and in this way a gas exchange between the container interior and the environment is possible. Consequently, in this, in the Fig. 1 state shown a freeze-drying of a stored in the container 18 solution possible.

In the in the Fig. 1 In the state shown, portions of the side surface 3 of the abutment portion 17 abut against an inner surface 21 of the container neck 19, whereby the plug 1 is held in its partially inserted position, and for further insertion of the plug 1 a force on the plug 1 in the axial direction Z in Direction of the container 18 is necessary.

The plug 1 has a sealing portion 16 adjacent to the abutment portion 17 in the direction of the top surface 5, the sealing portion 16 abutting the inner surface 21 of the container neck 19 in a state in which the insertion portion 2 is fully inserted into the container 18 thus sealing the container 18 sealing.

As in particular the sectional view of Fig. 6 can be seen, the plug 1, a sealing body 7 and a base body 8, wherein outer surfaces of the sealing body 7, the side surface 3 and the bottom surface 4 of the insertion section 2 form.

The main body 8 is formed in the region of the insertion section 2 within the sealing body 7, whereby only the sealing body 7 comes into contact with the inner surface 21 of the container 18 and the interior of the container 18. The sealing body 7 and the base body 8 are materially connected to each other. Due to the cohesive connection of the sealing body 7 and the base body 8 are permanently connected to each other, so that the plug 1 is formed quasi one piece. The cohesive connection is preferably produced by a multi-component injection molding process, in particular a two-component injection molding process.

The main body 8 and the sealing body 7 are made of different materials, wherein the base body 8 consists of a material which has a higher hardness than a material of which the sealing body 7 consists.

The sealing body 7 has in the region of the sealing portion 16 has a circular cross-section, wherein an outer radius R of the annulus is approximately twice an inner radius r of the annulus.

The sealing body 7 and the main body 8 are partially formed in the cover portion 10, wherein an outer surface of the base body 8 forms the top surface 5 and the top surface 5, the sealing body 7 in the axial direction Z covers.

In order to limit the insertion depth of the plug 1 in the axial direction Z and to improve the sealing effect of the plug 1 and to facilitate the removal of the plug 1 from the container 18, the cover portion 10 has a radial dimension which is greater than a radial dimension of the insertion section 2. In the fully inserted in the container 18 state of the plug 1 thus facing away from the top surface 5 support surface 11 of the cover 10 is located on the outer surface 20 of the container 18 at. This support surface 11 of the cover 10 is formed by an outer surface of the sealing body 7.

Both the base body 8 and the sealing body 7 of the plug 1 are formed radially symmetrical to an axis of symmetry 18 of the plug 1 extending in the axial direction Z.

The main body 8 is cylindrical both in the region of the insertion section 2 and substantially cylindrical in the region of the cover section 10, wherein the main body 8 in the region of the cover section 10 has a larger diameter than in the region of the insertion section 2.

Furthermore, in the region of the cover section 10, the main body 8 has a circumferential first projection 12 formed in the radial direction. This first projection 12 may, for example, serve to hold the plug 1 in an additional closure attachable to the container 18.

In order to further reduce the effective outer surface of the plug 1, the base body 8 covers in the in the 8 to 11 shown second embodiment of the plug 1, the sealing body 7 in the region of the cover portion 10 radially on the outside partially. For this purpose, the base body 8 in the region of the cover 10 has a radially outwardly extending, extending from the top surface 5 in the direction of the bottom surface 4 second projection 13, wherein the second projection 13, the sealing body 7 in the region of the cover 10 radially outward partially covering.

That in the 10 and 11 shown third embodiment of the plug 1 differs from that in the Fig. 8 and 9 embodiment shown essentially in that the plug 1 has formed between the base body 8 and the sealing body 7 blocking body 9 in the form of a barrier layer 9 in order to improve the blocking effect of the plug 1, for example against oxygen diffusion. The barrier layer 9 and / or the blocking body 9 may for example consist of ethylene-vinyl alcohol copolymer (EVOH) or aluminum. Preferably, the locking body 9 and / or the barrier layer 9 is materially connected to the base body 8 and / or materially connected to the sealing body 7. Such a plug 1 can be produced for example by means of a three-component injection molding process. But it is also quite conceivable that the blocking body 9 and / or the barrier layer 9 between the base body 8 and the sealing body 7 is clamped or positively held.

That in the Fig. 12 to 14 illustrated fourth embodiment of the plug 1 differs from the first embodiment essentially in that the base body 8 has a extending from the top surface 5 in the direction of the bottom surface 4, the central passageway 15, wherein a from the bottom surface 4 in the direction of the top surface 5 extending portion 14 of the sealing body 7 is formed in the passage 15, whereby the base 8 surrounds this portion 14 of the sealing body 7 radially. The passageway 15 allows removal of the contents of the container without removal of the plug 1 from the container 18, for example, by inserting a needle into the passage 15 and the sealing body 7 is pierced in the insertion of the needle.

Furthermore, such an embodiment of the plug 1 is particularly simple and inexpensive to produce by first the main body 8, for example by means of an injection molding process is prepared and then the sealing body 7 is molded onto the base body 8, wherein the injection molding of the sealing body 7 through the passage 15 of the main body 8 takes place. Due to the centrally formed passage 15 and thus the central gating of the sealing body 7 to the main body 8 also shape tolerances of the plug 1 are reduced.

In order to facilitate insertion of the plug 1, the exemplary embodiments of the plug 1 illustrated in the figures have a conical outer contour in a region of the contact section 17 which has the bottom surface 4.

LIST OF REFERENCE NUMBERS

1

Plug

2

insertion

3

side surface

4

floor area

5

cover surface

6

Port

7

sealing body

8th

body

9

Blocking body / barrier

10

cover

11

contact surface

12

first advantage

13

second lead

14

subregion

15

Through channel

16

sealing portion

17

contact section

18

container

19

container neck

20

outer surface

21

palm

Y

radial direction

Z

axial direction

Claims (15)

A plug (1) for a container (18) for use in freeze-drying, wherein the plug (1) has an insertion section (2) insertable into the container (18), the insertion section (2) has a side surface (3) and a bottom surface (4) ), wherein the bottom surface (4) of a top surface (5) of the plug (1) in an axial direction (Z) of the plug (1) is formed opposite, and the insertion section (2) has a sealing portion (16) and a contact portion ( 17), wherein the abutment section (17) has a passage opening (6) for a gas exchange, wherein the passage opening (6) extends from the side surface (3) into the bottom surface (4) and the plug (1) has a sealing body (7 ) and a base body (8) which are interconnected, characterized in that outer surfaces of the sealing body (7) form the side surface (3) and the bottom surface (4) of the insertion section (2), the base body (8) in the region of Einführabschn itts (2) is formed within the sealing body (7), wherein the base body (8) consists of a material which has a higher hardness than a material of which the sealing body (7) consists. Stopper (1) according to claim 1, characterized in that the sealing body (7) and the base body (8) are directly connected to each other, in particular directly cohesively connected to each other. Plug (1) according to claim 1 or 2, characterized in that the plug (1) has a blocking body (9) and / or a barrier layer (9), wherein the blocking body (9) and / or the barrier layer (9) between the Base body (8) and the sealing body (7) is formed, in particular the locking body (9) and / or the barrier layer (9) is materially connected to the base body (8) and / or materially connected to the sealing body (7). Stopper (1) according to one of claims 1 to 3, characterized in that an outer surface of the base body (8) forms the top surface (5) and the top surface (5) covers the sealing body (7) in the axial direction (Z). Plug (1) according to one of claims 1 to 4, characterized in that the plug (1) in the axial direction (Z) to the insertion section (2) adjacent the cover portion (10), wherein the cover portion (10) the top surface (5) and wherein a radial dimension of the cover section (10) is at least as large, in particular larger than a radial dimension of the insertion section (2). Stopper (1) according to claim 5, characterized in that an outer surface of the sealing body (8) faces away from the cover surface (5) bearing surface (11) of the cover (10). Plug (1) according to claim 5 or 6, characterized in that the base body (8) in the region of the cover section (10) has a first projection (12) formed in the radial direction, in particular the base body (8) in the region of the cover section (10 ) has a circumferential first projection (12) and / or the base body (8) the sealing body (7) in the region of the cover (10) radially outside at least partially covers, in particular the base body (8) in the region of the cover (10) has a radial externally formed, extending from the top surface (5) in the direction of the bottom surface (4) second projection (13), wherein the second projection (13) the sealing body (7) in the region of the cover (10) radially outside at least partially covers. Plug (1) according to one of claims 1 to 7, characterized in that the sealing body (7) in the region of the sealing portion (16) has a circular cross section, preferably a ratio of an outer radius (R) of the circular ring to an inner radius (r) of the annulus is 1.1 to 2.5. Plug (1) according to one of claims 1 to 8, characterized in that the base body (8) radially from the bottom surface (4) in the direction of the top surface (5) extending portion (14) of the sealing body (7) encloses. Plug (1) according to one of claims 1 to 9, characterized in that the base body (8) has a from the top surface (5) in the direction of the bottom surface (4) extending through channel (15), in particular extending from the bottom surface ( 4) in the direction of the top surface (5) extending portion (14) of the sealing body (7) in the passageway (15) is formed. Stopper (1) according to one of claims 1 to 10, characterized in that the sealing body (7) has a recess (6), wherein the recess (6) forms the passage opening (6). Plug (1) according to one of claims 1 to 11, characterized in that the sealing body (7) consists of a material having a hardness of Shore A 40 to 80, preferably a hardness of Shore A 50 to 70 according to DIN ISO 7619-1: 2010, and / or the sealing body (7) consists of a thermoplastic elastomer (TPE). Plug (1) according to one of claims 1 to 12, characterized in that the base body (8) consists of a material having a hardness of Shore D 30 to 100, preferably a hardness of Shore D 40 to 85 according to DIN ISO 7619-1: 2010, and / or the base body (8) consists of polypropylene (PP) or high-density polyethylene (HDPE). Stopper (1) according to one of claims 1 to 13, characterized in that the base body (8) and / or the sealing body (7) and / or the stopper (1) symmetrically to a in the axial direction (Z) extending symmetry axis ( 18) and / or symmetry plane. Stopper (1) according to one of claims 1 to 14, characterized in that a stopper (1) produced by means of a multi-component injection molding process, in particular a two-component or three-component injection molding process.

Images