EP3328346A1 - SCHWEIß VERRINGERNDE KOSMETISCHE ZUBEREITUNG - Google Patents
SCHWEIß VERRINGERNDE KOSMETISCHE ZUBEREITUNGInfo
- Publication number
- EP3328346A1 EP3328346A1 EP16738134.2A EP16738134A EP3328346A1 EP 3328346 A1 EP3328346 A1 EP 3328346A1 EP 16738134 A EP16738134 A EP 16738134A EP 3328346 A1 EP3328346 A1 EP 3328346A1
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- EP
- European Patent Office
- Prior art keywords
- cas
- phase
- cosmetic
- chamber
- product according
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/19—Cosmetics or similar toiletry preparations characterised by the composition containing inorganic ingredients
- A61K8/25—Silicon; Compounds thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/02—Cosmetics or similar toiletry preparations characterised by special physical form
- A61K8/04—Dispersions; Emulsions
- A61K8/06—Emulsions
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q15/00—Anti-perspirants or body deodorants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
- A61K2800/80—Process related aspects concerning the preparation of the cosmetic composition or the storage or application thereof
- A61K2800/87—Application Devices; Containers; Packaging
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
- A61K2800/80—Process related aspects concerning the preparation of the cosmetic composition or the storage or application thereof
- A61K2800/88—Two- or multipart kits
- A61K2800/882—Mixing prior to application
Definitions
- the present invention relates to a cosmetic for reducing or preventing apoekkrinen sweat formation from a packaging with two pantries and two cosmetic part preparations, characterized in that a chamber
- secreted aqueous secretion There are three types of sweat glands in the skin, namely, apocrine, eccrine, and apoekrine sweat glands (Int J Cosmet Sei. 2007 Jun;
- the eccrine sweat glands in humans are distributed practically throughout the body and can produce significant amounts of a clear, odorless secretion that is over 99% water.
- the apocrine sweat glands occur only in the hairy body areas of the armpit and genital region and on the nipples. They produce small amounts of a milky secretion that contains proteins and lipids and is chemically neutral.
- Sweating also known as transpiration, is an effective mechanism to release excess heat and thereby regulate body temperature.
- the volume-rich aqueous secretion of the eccrine glands which can produce up to 2-4 liters per hour or 10-14 liters a day in adults, is used for this purpose.
- the sweat - especially the secretion of apocrine sweat glands - is also signaled by the sense of smell. In humans, the apocrine sweat plays in particular in connection with the emotional or stress related
- Cosmetic antiperspirants or deodorants / deodorants are used to eliminate body odor or to reduce their formation.
- Body odor arises when the per se odorless fresh sweat by microorganisms such. Staphylococci and
- Deodorant and "antiperspirant”. Rather, especially in the German-speaking Space - products for use in the underarm area generally referred to as deodorants or "deodorants.” This is irrelevant to the question of whether an antiperspirant effect is present.
- Antiperspirants are antiperspirants that - in contrast to the
- Deodorants which generally prevent microbial decomposition of already formed sweat - to prevent the secretion of sweat at all.
- non-colloidal silver also shows odor neutralization (masking), influencing of bacterial metabolisms, the pure perfuming as well as the use of precursors of certain perfume components, which are converted by enzymatic reactions to fragrant substances.
- Sweat odor consists to a large extent of branched-chain fatty acids, which are released by bacterial enzymes from odorless sweat.
- Classic deodorizing agents counteract this by reducing the growth of bacteria.
- the substances used for this purpose also act nonselectively against useful skin germs and can lead to skin irritations in sensitive individuals.
- the classic antiperspirants used are, in particular, aluminum salts or aluminum / zirconium salts. These inhibit the flow of sweat by obstructing the excretory ducts of the sweat glands by precipitating them together with the skin's own proteins and thus leading to so-called plugs. Therefore, there may be a congestion of sweat within the gland.
- Corneocytes in the sweat gland duct (Shelley WB and Hurley HJ, Acta, Derm. Venereol. (1975) 55: 241-60), or by the emergence of an ACH / AZG gel (Reiler HH and Luedders WL, in: Advances in Modern Hemisphere Publishing Company, Washington and London. Toxicology, Dermatoxicology and Pharmacology, FN Marzulli and HI Maibach, Eds (1977) Vol. 4: 1-5) formed by neutralization in the sweat gland duct is still open.
- such aluminum salts as aluminum hydroxychlorides can cause skin damage if used frequently and on sensitive persons.
- the use of the aluminum salts can cause discoloration of textiles which come into contact with the antiperspirant.
- antiperspirants and deodorants (Deo) are offered in a variety of product forms, with scooters, pump sprayers and aerosols dominating in Europe, and deodorant sticks ("sticks") in the US, Central and South America. Both anhydrous (suspensions) and water-containing products (hydro-alcoholic formulations, emulsions) are known.
- a satisfactory deodorant means the following conditions are met: 1)
- liquid deodorants and antiperspirants Apart from the liquid deodorants and antiperspirants, solid preparations, for example powders, powder sprays, are also known and customary as intimate cleaners.
- the nature of the composition of cosmetic preparations finds its natural limits, due to the compatibility of the individual components with each other and the stability of
- EP 1026093 discloses a two-chamber packaging means in which the chambers are separated by a
- EP 462255 and EP 1044893 disclose a two-chamber packaging means in which the barrier between the chambers is removed prior to the first actuation of the spraying device and thus the mixture of chamber contents is applied.
- EP 0816253 discloses a two-chamber packing means in which by pressure on the one chamber a diaphragm separating the chambers is pierced and the contents of the one chamber reach the second chamber and can be mixed with its contents by shaking.
- Formulations in which ACH is present as a solid, are extremely stable.
- a disadvantage of the aluminum salts used hitherto for sweat inhibition is the currently not yet fully understood long-term toxicity.
- Aluminum has been suspected for a long time to promote or trigger neurodegenerative diseases such as dementia, in particular Alzheimer's disease. Also, aluminum is associated with the development of breast cancer. So far, there is no verified evidence that works over the skin
- silic acids are the oxygen acids of silicon.
- Polymers are sometimes referred to as meta-silicic acid (H2S1O3, [-Si (OH) 2-0-] n ). If these low-molecular-weight silicic acids continue to condense, amorphous colloids (silica sol) are formed.
- the general empirical formula of all silicas is H2n + 2Si n 03n + i.
- the empirical formula is often S1O2 ⁇ n H2O; However, the water is not with silicas
- Silica the anhydride of silicic acid.
- the salts of acids are called silicates.
- silicic acid esters are Technically used or prepared alkali metal salts.
- the esters of silicic acids are called silicic acid esters.
- Silica acids are understood to have an extension of 1 to 100 nm, measured by dynamic light scattering. These low molecular weight, highly amorphous silicas are also known as low molecular weight polysilicic acids and are referred to below as NPK.
- pH values below 3.5 are physiologically incompatible, formulations must be found in which the pH is at least 3.5 and in which there is no gelation or precipitation of amorphous colloids (silica sol).
- a further object of the present invention was therefore to develop a product which is suitable as the basis for cosmetic deodorants or antiperspirants and which does not have the disadvantages of the prior art, in particular is distinguished by good skin tolerance.
- the object of the invention is, in particular, to provide silicic acid-containing antiperspirant preparations comprising low molecular weight polysilicic acids (NPK) in combination with one or more stabilizers, with a physiologically tolerable pH having sufficient stability.
- NPK low molecular weight polysilicic acids
- Preparations having a pH of at least 3.5, containing NPK and one or more stabilizers for use as hypoallergenic antiperspirants, ie for reducing or preventing the apoekkrinen sweat formation, are suitable when the pH increase occurs shortly before the application and thereby the disadvantages of the prior art, the lack of stability of physiologically acceptable NPK preparations, is eliminated.
- the invention is therefore a cosmetic product comprising a two-chamber container suitable for the application of cosmetic preparations, characterized in that a chamber contains a partial preparation containing low molecular weight, highly amorphous silica (NPK) in combination with one or more stabilizers (phase 1) and the second chamber includes an emulsion preparation (phase 2), wherein the first and second chambers are separated by a barrier, whereby the barrier is destroyed by the action of forces on the second chamber, whereby the contents of the second chamber can pass into the first chamber and Mix contents of the first chamber and contents of the second chamber and the mixture can be removed.
- NPK highly amorphous silica
- the invention encompasses the use of NPK, as an antiperspirant active, preferably in topically administrable, in particular cosmetic and / or dermatological, preparations, wherein the pH of the preparation only before application to a
- physiologically acceptable level is set, in particular the pH of the applied preparation is not less than 3.5.
- the stabilizers are selected from group A:
- Hexenol ice 3 (CAS 928-96-1), terpineol (CAS 8000-41 -7), linalool (CAS 78-70-6),
- Tetrahydrolinalool (CAS 78-69-3), triethyl citrate (CAS 77-93-0), 2-isobutyl-4-hydroxy-4-methyltetrahydropyran (CAS 63500-71-0), hexyl salicylate (CAS 6259-76-3 ), Phenylethyl alcohol (CAS 60-12-8), 3-methyl-5-phenyl-1-pentanol (CAS 55066-48-3), 2,6-dimethyl-7-octene-2-o (CAS 18479 -58-8), benzyl salicylate (CAS 1 18-58-1), geraniol (CAS 106-24-1), citronellol (CAS 106-22-9) and ethyllinalool (CAS 10339-55-6); group B: alcohols and diols and group C: substances with at least three hydroxyl groups.
- Particularly advantageous are stabilizers from the group linalool (CAS 78-70-6), benzyl salicylate (CAS 1 18-58-1), geraniol (CAS 106-24-1) and citronellol (CAS 106-22-9).
- Particularly advantageous group B stabilizers are: ethanol, 2-propanol, PEG 8, triethylene glycol, methylphenylbutanol, decanediol, polyglyceryl-2-caprate, oxalic acid.
- Particularly advantageous stabilizers from group C are: sucrose (mannose, mannitol), glycerol, pentaerythritol, threitol, erythritol, hyaluronic acid.
- compositions - ie the use of cosmetic or dermatological preparations on the skin - containing NPK in combination with one or more stabilizers chosen from the group A, B and / or C allows the reduction or prevention of stress sweating.
- NPK act as a sweat inhibitor and reduce the formation of sweat and thus indirectly also the smell of sweat.
- NPK-containing preparation By mixing the NPK-containing preparation with an emulsion before application and application, preparations are provided which have a high physiological compatibility.
- NPK-containing preparation with the pH of the emulsion increasing the pH before the application of a two-chamber packaging makes the use of NPK-containing preparations as a compatible antiperspirant only possible.
- Products according to the invention with NPK allow an antiperspirant effect on the order of known and proven antiperspirant active ingredients, wherein the required concentration of NPK is much lower than when using ACH.
- Mixing with an emulsion only before application also leads to the elimination of the listed disadvantages, such as lack of storage stability of an NPK-containing emulsion and the toxicity of aluminum compounds under discussion.
- products according to the invention preferably comprise, in addition to an NPK-containing preparation, no further antiperspirant substances or preparations, in particular no aluminum salts, in particular no ACH and / or AACH (activated aluminum chlorohydrate).
- An essential advantage of the products according to the invention is, moreover, that no discoloration on the skin or clothing is evident as compared with the AT agents based on aluminum salts. The so-called whiteness as well as those after repeated wearing and washing in textiles resting directly on the underarm skin are not observed
- the stabilized silicas can be incorporated in a simple manner into the compositions suitable for products according to the invention. They are preferably added as NPK solution to the other constituents of the formulations. The proportion of NPK solution can make up to 98% of the total amount of the formulation. in the
- a thickener and a perfume are added to the NPK suspension, perfume meaning a mixture comprising one or more olfactorily detectable individual substances.
- Silica acids stabilized for use according to the invention can be e.g. Produce according to the following methods on a laboratory scale: Method I:
- step 2 for pH reduction are particularly suitable.
- pH reduction can also be carried out any other acids, as long as they a) can reduce the pH accordingly and b) their salts, in particular sodium salt, are physiologically acceptable or cause no skin irritation. Preference is given to pH reduction
- the fast pH reduction is crucial for the successful formation of the NPK.
- step 3 Increasing the pH in step 3 to a cosmetically acceptable level is optional and can be accomplished with caustic soda, caustic potash, or with weaker bases.
- Useful bases include: 2-aminobutanol, 2- (2-aminoethoxy) ethanol, aminoethyl
- Propanediol Aminomethyl Propanediol, Aminomethyl Propanol, Aminopropanediol, Bis-Hydroxyethyl Tromethamine, Butyl Diethanolamine, Butylethanolamine, Dibutyl Ethanolamine, Diethanolamine, Diethyl Ethanolamine, Diisopropanolamine, Dimethylamino Methylpropanol, Dimethyl Isopropanolamine, Dimethyl MEA, Ethanolamine, Ethyl Ethanolamine,
- Isopropanolamines methyl diethanolamines, methylethanolamines, triethanolamines,
- Triisopropanolamines Triisopropanolamines, tromethamines, polyethylenimines, tetrahydroxypropylethylenediamine, ammonia.
- the increase in pH can also be carried out with buffer systems, which is also considered in the context of the invention as a base, which are added either in aqueous solution or anhydrous.
- the buffer systems can consist of the abovementioned bases and cosmetically acceptable acids and have a pH of from 3 to 11, preferably from 7 to 9.
- Alkali hydroxides whose cations are physiologically compatible and easy to keep in solution.
- sodium and / or potassium hydroxide solution are suitable for raising the pH.
- the pH increase can be advantageously carried out in stages, with a more concentrated base, e.g. 5N NaOH, and only to adjust the final pH, a less concentrated base, e.g. 0.5N NaOH, is used.
- Particularly suitable stabilizers for this preparation method are ethanol, glycerol, 2-propanol, PEG 8, triethylene glycol, urea, oxalic acid, hyaluronic acid, ethylhexylglycerol, pentaerythritol, threitol, erythritol, methylphenylbutanol, polyglyceryl 2-caprate, decanediol
- glycerol and ethanol in a ratio of 1:10 to 6:10, in particular 5 to 30 wt .-% glycerol and 30 wt .-% EtOH based on the total amount of sodium silicate solution prepared in step 1.
- step 3 The same conditions apply to the pH reduction (step 3) and the pH increase (step 4) as to step 2 and step 3 of method I.
- Suitable stabilizers for this stabilized NPK preparation process are sucrose, mannose and / or mannitol.
- step 2 The same conditions apply to the pH reduction (step 2) and the pH increase (step 3) as to step 2 and step 3 of method I.
- Suitable stabilizers for this stabilized NPK preparation process is glycerol.
- the pH increase with 0.1 to 0.5 M sodium hydroxide in glycerol is advantageous, as this possible, pH peaks' can be prevented.
- step 2 (method I and III) and step 3 (method II) by combining the reactants
- the stability increases with decreasing temperature, so that storage in the refrigerator (at 5 to 8 degrees Celsius) is advantageous.
- the cosmetic products according to the invention containing in a chamber a stabilized NPK preparation, in the form of aerosols, so from
- roll-on devices application via moving bodies, for example ball or roller.
- optional w / o or o / w emulsions which may be applied from ordinary dual-chambered bottles and containers, e.g. Creams or lotions.
- a good method is also the spreading or rubbing by means of flat applicators, which are fed by a two-chamber container, in particular applicators with flocked and / or textile surface, since they have a low tendency to clog.
- Preferred application form for the antiperspirants with stabilized NPK are water-containing aerosols.
- the hydrous aerosols especially the W / O emulsions are mentioned.
- This form of application is preferred, since it represents the most common form in the world of deodorant / AT.
- the stabilized NPK is present dissolved in the preparation and does not have to be resuspended by shaking before using the spray. The clogging probability of the nozzles is thereby reduced.
- pump sprays offer a contactless application of the AT preparation to the skin.
- pressure-resistant containers can be dispensed with.
- Two-chamber pump sprays can be made metal-free, in particular aluminum-free.
- containers made of PE, PP or PET which are closed with one or two metal-free atomizer (s), where metal-free means that the pumped preparation does not come into contact with metallic components.
- metal-free means that the pumped preparation does not come into contact with metallic components.
- the feed is via one or two risers and the mixture of the NPK-containing preparation (phase 1) with the emulsion (phase 2) takes place before or after the pump (s) .
- Aerosol Spray Aerosol Spray:
- the stabilized NPK (Phase 1) are in the inventive
- Antiperspirant formulations preferably in an amount of 0, 1 to 10 wt .-%, content of NPK based on the total mass of the preparation, i. including the possibly existing propellants used. Particularly advantageous are concentrations of 0.5 to 3 wt .-%.
- concentrations 0.5 to 3 wt .-%.
- the proportion of one or more stabilizers in phase 1 can advantageously be selected up to 85% by weight, in particular up to 30% by weight, based on the total mass of the preparation.
- the proportion of SiO 2 equivalents in phase 1 is advantageously in the range of 0.1. Up to 6 wt .-%, preferably 0.5 to 3 wt .-%, based on the total mass of the preparation selected.
- the proportion of one or more stabilizers in phase 1 can advantageously be selected up to 85% by weight, in particular up to 30% by weight, based on the total mass of the preparation.
- the proportion of NPK in phase 1 is advantageously in the range of 0, 1 to 6 wt .-%, preferably 0.5 to 3 wt .-%, based on the total mass of the preparation chosen.
- the preparations containing stabilized NPK (phase 1) or the emulsion (phase 2) contain cosmetic auxiliaries as are customarily used in such preparations, for example preservatives, preserving aids, Bactericides, perfumes, UV filters, antioxidants, water-soluble vitamins, minerals, suspended solid particles, foaming inhibitors, dyes, pigments having a coloring effect, thickeners, moisturizing and / or moisturizing substances or other common ingredients of a cosmetic or dermatological Formulation such as electrolytes, organic solvents, alcohols, polyols, emulsifiers, polymers, foam stabilizers or silicone derivatives.
- cosmetic auxiliaries as are customarily used in such preparations, for example preservatives, preserving aids, Bactericides, perfumes, UV filters, antioxidants, water-soluble vitamins, minerals, suspended solid particles, foaming inhibitors, dyes, pigments having a coloring effect, thickeners, moisturizing and / or moisturizing substances or other common ingredients of a cosmetic or dermatological Formulation such
- the preparations are preferably produced and used in an optically appealing transparent manner.
- Phase 2 is advantageously characterized in that it is in the form of an aqueous or aqueous-alcoholic solution, an emulsion (W / O, O / W, W / Si, Si / W or multiple emulsion, macro, micro or nanoemulsion). , a dispersion, a Pickering emulsion, a gel, a hydrodispersion gel or an anhydrous preparation.
- phase 1 and phase 2 can also be added to deodorants.
- the usual cosmetic deodorants are based on different active principles.
- antimicrobial substances as cosmetic deodorants, the bacterial flora on the skin can be reduced.
- only the odor causing microorganisms should be effectively reduced.
- the sweat flow itself is not affected, in the ideal case, only the microbial decomposition of the sweat is temporarily stopped.
- the combination of astringents with antimicrobial substances in one and the same composition is also common.
- odor maskers such as the common perfume ingredients, odor absorbers, for example the phyllosilicates described in DE 40 09 347, of these in particular montmorillonite, kaolinite, mit, beidellite, nontronite, saponite, hectorite, bentonite, smectite , furthermore, for example, zinc salts of ricinoleic acid.
- Germ-inhibiting agents are also suitable for incorporation into the preparations according to the invention.
- Advantageous substances are, for example, 2,4,4'-trichloro-2'-hydroxydiphenyl ether (Irgasan), 1, 6-di- (4-chlorphenylbiguanido) hexane (chlorhexidine), 3,4,4'-trichlorocarbanilide, quaternary ammonium compounds , Clove oil, mint oil, thyme oil, triethyl citrate, farnesol (3,7,1-t-trimethyl-2, 6,10-dodecatriene-1-ol),
- sodium bicarbonate is advantageous to use.
- an antimicrobial silver citrate complex as described in DE 202008014407, can preferably be used as a deodorizing component in conjunction with NPK.
- phase 1 and / or phase 2 also contain polymers.
- the polymers preferably originate from the range of celluloses and / or polystyrenes. They are advantageously hydrophobic or hydrophilic modified. They serve to adjust the viscosity of the phases and facilitate the pumpability and miscibility, as well as the drain or
- Usable polymers therefore include celluloses, polystyrenes and / or alkyl-acrylic
- Crosspolymers and may optionally be added to the NPK preparations.
- phase 1 and 2 of the product according to the invention in addition to water, ethanol and isopropanol, glycerol and propylene glycol skin-care fat or fat-like substances and oils such as oleic acid, cetyl alcohol,
- slime-forming and film-forming substances and thickening agents e.g. Hydroxyethyl or hydroxypropyl cellulose, polyacrylic acid, polyvinylpyrrolidone and waxes.
- phase 2 preparations which can be used according to the invention: polyoxyethylene (20) sorbitan monolaurate, polyoxyethylene (20) sorbitan monopalmitate,
- Glucosides PEG-8 Oleates, Polyglyceryl-3 Methyglucose Distearates, PG-10 Stearates, Oleth-10, Oleth-10 / Polyoxyl 10 Oleyl Ether NF, Ceteth-10, PEG-8 Laurate, Ceteareth-12, Cocamide MEA, Polysorbate 60 NF, Polysorbate 60, PEG-40 Hydrogenated Castor Oil, Polysorbate 80, Isosteareth-20, PEG-60 Almond Glycerides, Polysorbate 80 NF, PEG-150 Laurate, PEG-20 Methyl glucose sesquistearates, ceteareth-20, oleth-20, steareth-20, steareth-21, ceteth-20, isoceteth-20, PEG-30 glyceryl laurate, polysorbate 20, polysorbate 20 NF, laureth-23, PEG-100 stearates, Steareth-100, PEG-80 sorbitan laurate.
- glyceryl isostearates Preference is given to using glyceryl isostearates, glyceryl stearates, steareth-2, ceteareth-20, steareth-21, PEG-40 hydrogenated castor oil, PG-10 stearates, isoceteth-20, isosteareth-20 and ceteareth-12.
- solubilizers also known as solubilizers but useful as emulsifiers for the Phase 2 preparations of the invention are PEG-40 Hydrogenated Castor Oil, Polysorbate 80, Laureth-23, PEG-150 Laurate and PEG-30 Glyceryl Laurate.
- suitable cationic emulsifiers are from the group Cetrimonium Chloride, Palmitamidopropyltrimonium Chloride, Quaternium-87, Behentrimonium Chloride, Distearoylethyl Dimonium Chloride, Distearyldimonium Chloride, Stearamidopropyl
- Dimethylamine and / or Behentrimonium methosulfate Dimethylamine and / or Behentrimonium methosulfate.
- antioxidants which are suitable or customary for cosmetic and / or dermatological applications can be used as favorable antioxidants.
- the amount of antioxidants (one or more compounds) in the preparations is preferably from 0.001 to 30% by weight, particularly preferably from 0.05 to 20% by weight, in particular from 1 to 10% by weight, based on the total weight of the preparation ,
- phase 2 is a solution or emulsion or dispersion, it can act as a solvent, bodying agent and / or
- Oils such as triglycerides of capric or caprylic and alkyl benzoate, but preferably cyclic silicone oils or volatile hydrocarbons;
- esters of fatty acids with low C-number alcohols eg with isopropanol, propylene glycol or glycerol, or esters of fatty alcohols with low C-number alkanoic acids or with fatty acids
- Vegetable oils such as avocado oil, meadowfoam seed oil, olive oil, Sunflower oil, rapeseed oil, almond oil, evening primrose oil, coconut oil. Palm oil, linseed oil, shea butter.
- Alcohols, diols or polyols of low C number, and their ethers in particular propylene glycol, glycerol, ethylene glycol, ethylene glycol monoethyl or monobutyl ether, propylene glycol monomethyl, monoethyl or monobutyl ether, diethylene glycol monomethyl or monoethyl ether and analogous products.
- Skin care substances such as Panthenol, allantoin, urea, urea derivatives, guanidine, ascorbic acid, glyceryl glucose
- mixtures of the aforementioned ingredients are used.
- water can be another ingredient.
- Suitable propellants for sprayable from aerosol containers cosmetic and / or dermatological preparations in the context of the present invention the usual known volatile, liquefied propellants, such as hydrocarbons (propane, butane, isobutane) are suitable, which can be used alone or in mixture with each other. Also, the usual known volatile, liquefied propellants, such as hydrocarbons (propane, butane, isobutane) are suitable, which can be used alone or in mixture with each other. Also, hydrocarbons (propane, butane, isobutane) are suitable, which can be used alone or in mixture with each other. Also, the usual known volatile, liquefied propellants, such as hydrocarbons (propane, butane, isobutane) are suitable, which can be used alone or in mixture with each other. Also, the usual known volatile, liquefied propellants, such as hydrocarbons (propane, butane, isobutane) are suitable, which can be used alone
- Dimethyl ether, nitrous oxide, carbon dioxide, nitrogen and compressed air are advantageous to use.
- oils are often added, which are miscible in the drug solution with the propellant gas (propane, butane, isobutane), as an oil that is immiscible, leads to precipitation, which in the glass aerosol cause the drug particles are no longer divulg why eln are.
- Phase 2 cosmetic preparations can also be in the form of gels which, in addition to an effective content of the active ingredient according to the invention and solvents customarily used for this purpose, preferably water, also contain organic thickeners (thickeners), e.g.
- Tamarind flour preferably methylcellulose, hydroxymethylcellulose, hydroxyethylcellulose, hydroxypropylcellulose, hydroxypropylmethylcellulose, carboxymethylcellulose or a mixture of polyethylene glycol and polyethylene glycol stearate or distearate ,
- the thickener is in the formulation for example, in an amount between 0, 1 and 40 wt .-%, preferably between 0.5 and 25 wt .-%, contain.
- the numbers represent parts by weight, based on the total mass of the preparation.
- Steareth-21 (Tego alkanol S 21, 6.7 6.7 6.7 6.7 6.7 6.7
- Steareth-2 (Tego Alkanol S2, 11.7 11.7 11.7 11.7 11.7 11.7 11.7 Evonik Industries)
- Trisodium EDTA 20% (Edeta 5,0 5,0 5,0 5,0 5,0).
- Phase 2 In which the water-soluble constituents are heated together with the specified amount of water to 75 ° C. The oil components and emulsifiers are heated separately to 75 ° C. The phases are combined and homogenized. The emulsion is cooled to room temperature with stirring.
- Phase 1 and Phase 2 may be in different proportions from the
- ratios of 10:90 to 90:10 can be predetermined by different pump volumes.
- the axillary sweat volume is determined gravimetrically by cotton pads are balanced in the sauna after a 15min sweat phase.
- the relative sweat reduction for the silica compared to the untreated area is 54, 1%.
- the efficacy is therefore at the level of 10% ACH (see table). sample baseline after application rel. Reduction significance
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Abstract
Description
Claims
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
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DE102015214137.3A DE102015214137A1 (de) | 2015-07-27 | 2015-07-27 | Schweiß verringernde kosmetische Zubereitung |
PCT/EP2016/066389 WO2017016856A1 (de) | 2015-07-27 | 2016-07-11 | SCHWEIß VERRINGERNDE KOSMETISCHE ZUBEREITUNG |
Publications (1)
Publication Number | Publication Date |
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EP3328346A1 true EP3328346A1 (de) | 2018-06-06 |
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Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
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EP16738134.2A Withdrawn EP3328346A1 (de) | 2015-07-27 | 2016-07-11 | SCHWEIß VERRINGERNDE KOSMETISCHE ZUBEREITUNG |
Country Status (8)
Country | Link |
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US (1) | US20180214358A1 (de) |
EP (1) | EP3328346A1 (de) |
JP (1) | JP2018521099A (de) |
CN (1) | CN107847403A (de) |
AU (1) | AU2016299195A1 (de) |
BR (1) | BR112018001793A2 (de) |
DE (1) | DE102015214137A1 (de) |
WO (1) | WO2017016856A1 (de) |
Families Citing this family (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP3866750A4 (de) * | 2018-10-17 | 2022-07-27 | Austin Research Labs Corp. | Suspensionsformulierungen von dispersionen mit hoher last |
CN112618407A (zh) * | 2020-12-30 | 2021-04-09 | 宇肽生物(东莞)有限公司 | 一种稳定即用型多肽微乳液及其制备方法 |
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DE1270739B (de) * | 1961-06-26 | 1968-06-20 | Dr Med Georg Wolf Ernst | Mittel zur kosmetischen Behandlung der Haut |
CH470183A (de) * | 1968-09-27 | 1969-03-31 | Charles Olivier Fa | Schweissgeruch verhinderndes Mittel |
US3705940A (en) * | 1969-02-07 | 1972-12-12 | Degussa | Silicic acid-containing dentifrice |
FR2223049A1 (en) * | 1973-03-30 | 1974-10-25 | Conditionnement Cosmetologie N | Halogenate antibacterial compns. - potentiated with alkali metal salts or capric, caproic and caprylic acids |
CA1037868A (en) * | 1973-07-18 | 1978-09-05 | Martin Callingham | Organic deodorant compositions |
DE3740186A1 (de) | 1987-06-24 | 1989-01-05 | Beiersdorf Ag | Desodorierende und antimikrobielle zusammensetzung zur verwendung in kosmetischen oder topischen zubereitungen |
CA1330538C (en) * | 1988-04-14 | 1994-07-05 | Maria A. Curtin | Antiperspirant and method of making same |
DE3938140A1 (de) | 1989-11-16 | 1991-08-08 | Beiersdorf Ag | Desodorierende kosmetische mittel |
ES2064990T3 (es) | 1990-01-08 | 1995-02-01 | Becton Dickinson France | Frasco de almacenamiento y transferencia con doble compartimento. |
DE4009347A1 (de) | 1990-03-23 | 1991-09-26 | Beiersdorf Ag | Desodorierende kosmetische mittel |
DE4204321A1 (de) | 1992-02-13 | 1993-08-19 | Beiersdorf Ag | Verfahren zur isolierung und reinigung von fettsaeuren und hydroxyfettsaeuren und verwendungen von hydroxyfettsaeuren sowie zubereitungen, die sie enthalten |
DE4229737C2 (de) | 1992-09-05 | 1996-04-25 | Beiersdorf Ag | Desodorierende kosmetische Mittel mit einem Gehalt an Fettsäuren |
DE4229707A1 (de) | 1992-09-05 | 1994-03-10 | Beiersdorf Ag | Germicide Wirkstoffkombinationen |
DE4237081C2 (de) | 1992-11-03 | 1996-05-09 | Beiersdorf Ag | Verwendung von Di- oder Triglycerinestern als Deowirkstoffe |
DE4309372C2 (de) | 1993-03-23 | 1997-08-21 | Beiersdorf Ag | Kosmetische Desodorantien, enthaltend Gemische aus Wollwachssäuren oder Wollwachssäurekomponenten und Fettsäurepartialglyceriden unverzweigter Fettsäuren |
DE4324219C2 (de) | 1993-07-20 | 1995-08-10 | Beiersdorf Ag | Desodorierende Wirkstoffkombinationen auf der Basis von alpha, omega-Alkandicarbonsäuren und Wollwachssäuren |
FR2750397B1 (fr) | 1996-06-28 | 1998-08-07 | Oreal | Dispositif pour le stockage separe d'au moins deux produits, leur melange et la distribution du melange ainsi obtenu et procede de fabrication |
DE19902962C1 (de) | 1999-01-26 | 2000-07-06 | Goldwell Gmbh | Zweikomponentenbehältnis und Verfahren zu dessen Herstellung |
FR2792298B1 (fr) | 1999-04-16 | 2001-06-01 | Oreal | Dispositif pour le melange extemporane d'au moins deux produits dont un est notamment une poudre |
EP1110909A1 (de) * | 1999-12-24 | 2001-06-27 | Bio Minerals N.V. | Verfahren zur Herstellung von Orthokieselsäure, sowie nach dem Verfahren hergestellte Kieselsäure und ihre Verwendung |
PL206314B1 (pl) * | 2002-05-31 | 2010-07-30 | Sabalo Nvsabalo Nv | Roztwór wodny zawierający kwas borowy i niekoloidowy kwas krzemowy oraz dodatek pochłaniający wodę, sposób jego wytwarzania i jego zastosowanie |
DE10237460A1 (de) * | 2002-08-16 | 2004-02-26 | Beiersdorf Ag | Schminkprodukt |
GB0403409D0 (en) * | 2003-11-06 | 2004-03-24 | Unilever Plc | Improved detergent composition with benefit agents |
US7303767B2 (en) * | 2005-02-03 | 2007-12-04 | J.M. Huber Corporation | Personal care compositions comprising coated/treated metal silicate absorbent particles |
US20070148113A1 (en) * | 2005-12-05 | 2007-06-28 | Cyril Lemoine | Antiperspirant compositions comprising at least one dispersion of cationic colloidal silica particles, antiperspirant product, and cosmetic process for treating perspiration |
DE102005059935A1 (de) * | 2005-12-13 | 2007-06-14 | Henkel Kgaa | Kosmetisches Mittel mit gesteigerter Duftintensität und -persistenz |
DE202007003056U1 (de) * | 2006-06-19 | 2007-07-12 | Beiersdorf Ag | Kombinationsset zur dekorativen Pflege der Haut |
DE102008031927B4 (de) | 2008-07-08 | 2017-09-14 | Beiersdorf Ag | Kosmetische Zubereitungen mit passiviertem Silber |
FR2977151B1 (fr) * | 2011-06-28 | 2013-09-27 | Oreal | Utilisation cosmetique comme actif anti-transpirant d'un silicate alcalin |
EP2457846A3 (de) * | 2012-02-16 | 2012-06-27 | Bayer MaterialScience AG | Abgabemodul für kosmetische Zusammensetzungen |
CA2892427C (en) * | 2012-12-19 | 2021-06-08 | Colgate-Palmolive Company | Two component compositions containing zinc amino acid halide complexes and cysteine |
FR3006178B1 (fr) * | 2013-05-30 | 2015-06-26 | Oreal | Utilisation cosmetique comme actif deodorant d'un materiau silicie obtenu par hydrolyse et condensation d'un tetraalcoxysilane et d'un c7-c20-alkyl trialcoxysilane |
-
2015
- 2015-07-27 DE DE102015214137.3A patent/DE102015214137A1/de not_active Withdrawn
-
2016
- 2016-07-11 WO PCT/EP2016/066389 patent/WO2017016856A1/de active Application Filing
- 2016-07-11 US US15/746,839 patent/US20180214358A1/en not_active Abandoned
- 2016-07-11 AU AU2016299195A patent/AU2016299195A1/en not_active Abandoned
- 2016-07-11 BR BR112018001793A patent/BR112018001793A2/pt active Search and Examination
- 2016-07-11 EP EP16738134.2A patent/EP3328346A1/de not_active Withdrawn
- 2016-07-11 CN CN201680043701.0A patent/CN107847403A/zh active Pending
- 2016-07-11 JP JP2018504206A patent/JP2018521099A/ja active Pending
Also Published As
Publication number | Publication date |
---|---|
BR112018001793A2 (pt) | 2018-09-11 |
DE102015214137A1 (de) | 2017-02-02 |
CN107847403A (zh) | 2018-03-27 |
AU2016299195A1 (en) | 2018-02-15 |
WO2017016856A1 (de) | 2017-02-02 |
JP2018521099A (ja) | 2018-08-02 |
US20180214358A1 (en) | 2018-08-02 |
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