EP3292881A1 - Dispositif de transfert de fluide - Google Patents

Dispositif de transfert de fluide Download PDF

Info

Publication number
EP3292881A1
EP3292881A1 EP17195514.9A EP17195514A EP3292881A1 EP 3292881 A1 EP3292881 A1 EP 3292881A1 EP 17195514 A EP17195514 A EP 17195514A EP 3292881 A1 EP3292881 A1 EP 3292881A1
Authority
EP
European Patent Office
Prior art keywords
reservoir
cannula
transfer device
fluid transfer
fluid
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Withdrawn
Application number
EP17195514.9A
Other languages
German (de)
English (en)
Inventor
Robert R. Gonnelli
Robert L. Standley
Steven F. Levesque
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Mannkind Corp
Original Assignee
Valeritas Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Valeritas Inc filed Critical Valeritas Inc
Publication of EP3292881A1 publication Critical patent/EP3292881A1/fr
Withdrawn legal-status Critical Current

Links

Images

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61J—CONTAINERS SPECIALLY ADAPTED FOR MEDICAL OR PHARMACEUTICAL PURPOSES; DEVICES OR METHODS SPECIALLY ADAPTED FOR BRINGING PHARMACEUTICAL PRODUCTS INTO PARTICULAR PHYSICAL OR ADMINISTERING FORMS; DEVICES FOR ADMINISTERING FOOD OR MEDICINES ORALLY; BABY COMFORTERS; DEVICES FOR RECEIVING SPITTLE
    • A61J1/00—Containers specially adapted for medical or pharmaceutical purposes
    • A61J1/14—Details; Accessories therefor
    • A61J1/20—Arrangements for transferring or mixing fluids, e.g. from vial to syringe
    • A61J1/2089—Containers or vials which are to be joined to each other in order to mix their contents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61J—CONTAINERS SPECIALLY ADAPTED FOR MEDICAL OR PHARMACEUTICAL PURPOSES; DEVICES OR METHODS SPECIALLY ADAPTED FOR BRINGING PHARMACEUTICAL PRODUCTS INTO PARTICULAR PHYSICAL OR ADMINISTERING FORMS; DEVICES FOR ADMINISTERING FOOD OR MEDICINES ORALLY; BABY COMFORTERS; DEVICES FOR RECEIVING SPITTLE
    • A61J1/00—Containers specially adapted for medical or pharmaceutical purposes
    • A61J1/14—Details; Accessories therefor
    • A61J1/20—Arrangements for transferring or mixing fluids, e.g. from vial to syringe
    • A61J1/2003—Accessories used in combination with means for transfer or mixing of fluids, e.g. for activating fluid flow, separating fluids, filtering fluid or venting
    • A61J1/2048—Connecting means
    • A61J1/2058—Connecting means having multiple connecting ports
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61J—CONTAINERS SPECIALLY ADAPTED FOR MEDICAL OR PHARMACEUTICAL PURPOSES; DEVICES OR METHODS SPECIALLY ADAPTED FOR BRINGING PHARMACEUTICAL PRODUCTS INTO PARTICULAR PHYSICAL OR ADMINISTERING FORMS; DEVICES FOR ADMINISTERING FOOD OR MEDICINES ORALLY; BABY COMFORTERS; DEVICES FOR RECEIVING SPITTLE
    • A61J1/00—Containers specially adapted for medical or pharmaceutical purposes
    • A61J1/14—Details; Accessories therefor
    • A61J1/20—Arrangements for transferring or mixing fluids, e.g. from vial to syringe
    • A61J1/2003—Accessories used in combination with means for transfer or mixing of fluids, e.g. for activating fluid flow, separating fluids, filtering fluid or venting
    • A61J1/2068—Venting means
    • A61J1/2072—Venting means for internal venting
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61J—CONTAINERS SPECIALLY ADAPTED FOR MEDICAL OR PHARMACEUTICAL PURPOSES; DEVICES OR METHODS SPECIALLY ADAPTED FOR BRINGING PHARMACEUTICAL PRODUCTS INTO PARTICULAR PHYSICAL OR ADMINISTERING FORMS; DEVICES FOR ADMINISTERING FOOD OR MEDICINES ORALLY; BABY COMFORTERS; DEVICES FOR RECEIVING SPITTLE
    • A61J1/00—Containers specially adapted for medical or pharmaceutical purposes
    • A61J1/14—Details; Accessories therefor
    • A61J1/20—Arrangements for transferring or mixing fluids, e.g. from vial to syringe
    • A61J1/2096—Combination of a vial and a syringe for transferring or mixing their contents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M39/00—Tubes, tube connectors, tube couplings, valves, access sites or the like, specially adapted for medical use
    • A61M39/22—Valves or arrangement of valves
    • A61M39/24—Check- or non-return valves
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/14—Infusion devices, e.g. infusing by gravity; Blood infusion; Accessories therefor
    • A61M5/142—Pressure infusion, e.g. using pumps
    • A61M5/145—Pressure infusion, e.g. using pumps using pressurised reservoirs, e.g. pressurised by means of pistons
    • A61M5/148—Pressure infusion, e.g. using pumps using pressurised reservoirs, e.g. pressurised by means of pistons flexible, e.g. independent bags
    • A61M5/152—Pressure infusion, e.g. using pumps using pressurised reservoirs, e.g. pressurised by means of pistons flexible, e.g. independent bags pressurised by contraction of elastic reservoirs
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/14—Infusion devices, e.g. infusing by gravity; Blood infusion; Accessories therefor
    • A61M5/168—Means for controlling media flow to the body or for metering media to the body, e.g. drip meters, counters ; Monitoring media flow to the body
    • A61M5/16877—Adjusting flow; Devices for setting a flow rate
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B65—CONVEYING; PACKING; STORING; HANDLING THIN OR FILAMENTARY MATERIAL
    • B65B—MACHINES, APPARATUS OR DEVICES FOR, OR METHODS OF, PACKAGING ARTICLES OR MATERIALS; UNPACKING
    • B65B3/00—Packaging plastic material, semiliquids, liquids or mixed solids and liquids, in individual containers or receptacles, e.g. bags, sacks, boxes, cartons, cans, or jars
    • B65B3/26—Methods or devices for controlling the quantity of the material fed or filled
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01F—MEASURING VOLUME, VOLUME FLOW, MASS FLOW OR LIQUID LEVEL; METERING BY VOLUME
    • G01F11/00—Apparatus requiring external operation adapted at each repeated and identical operation to measure and separate a predetermined volume of fluid or fluent solid material from a supply or container, without regard to weight, and to deliver it
    • G01F11/10—Apparatus requiring external operation adapted at each repeated and identical operation to measure and separate a predetermined volume of fluid or fluent solid material from a supply or container, without regard to weight, and to deliver it with measuring chambers moved during operation
    • G01F11/26—Apparatus requiring external operation adapted at each repeated and identical operation to measure and separate a predetermined volume of fluid or fluent solid material from a supply or container, without regard to weight, and to deliver it with measuring chambers moved during operation wherein the measuring chamber is filled and emptied by tilting or inverting the supply vessel, e.g. bottle-emptying apparatus
    • G01F11/262—Apparatus requiring external operation adapted at each repeated and identical operation to measure and separate a predetermined volume of fluid or fluent solid material from a supply or container, without regard to weight, and to deliver it with measuring chambers moved during operation wherein the measuring chamber is filled and emptied by tilting or inverting the supply vessel, e.g. bottle-emptying apparatus for liquid or semi-liquid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61J—CONTAINERS SPECIALLY ADAPTED FOR MEDICAL OR PHARMACEUTICAL PURPOSES; DEVICES OR METHODS SPECIALLY ADAPTED FOR BRINGING PHARMACEUTICAL PRODUCTS INTO PARTICULAR PHYSICAL OR ADMINISTERING FORMS; DEVICES FOR ADMINISTERING FOOD OR MEDICINES ORALLY; BABY COMFORTERS; DEVICES FOR RECEIVING SPITTLE
    • A61J1/00—Containers specially adapted for medical or pharmaceutical purposes
    • A61J1/14—Details; Accessories therefor
    • A61J1/20—Arrangements for transferring or mixing fluids, e.g. from vial to syringe
    • A61J1/2003—Accessories used in combination with means for transfer or mixing of fluids, e.g. for activating fluid flow, separating fluids, filtering fluid or venting
    • A61J1/2006—Piercing means
    • A61J1/201—Piercing means having one piercing end
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61J—CONTAINERS SPECIALLY ADAPTED FOR MEDICAL OR PHARMACEUTICAL PURPOSES; DEVICES OR METHODS SPECIALLY ADAPTED FOR BRINGING PHARMACEUTICAL PRODUCTS INTO PARTICULAR PHYSICAL OR ADMINISTERING FORMS; DEVICES FOR ADMINISTERING FOOD OR MEDICINES ORALLY; BABY COMFORTERS; DEVICES FOR RECEIVING SPITTLE
    • A61J1/00—Containers specially adapted for medical or pharmaceutical purposes
    • A61J1/14—Details; Accessories therefor
    • A61J1/20—Arrangements for transferring or mixing fluids, e.g. from vial to syringe
    • A61J1/2003—Accessories used in combination with means for transfer or mixing of fluids, e.g. for activating fluid flow, separating fluids, filtering fluid or venting
    • A61J1/2006—Piercing means
    • A61J1/2017—Piercing means having three or more piercing ends
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61J—CONTAINERS SPECIALLY ADAPTED FOR MEDICAL OR PHARMACEUTICAL PURPOSES; DEVICES OR METHODS SPECIALLY ADAPTED FOR BRINGING PHARMACEUTICAL PRODUCTS INTO PARTICULAR PHYSICAL OR ADMINISTERING FORMS; DEVICES FOR ADMINISTERING FOOD OR MEDICINES ORALLY; BABY COMFORTERS; DEVICES FOR RECEIVING SPITTLE
    • A61J1/00—Containers specially adapted for medical or pharmaceutical purposes
    • A61J1/14—Details; Accessories therefor
    • A61J1/20—Arrangements for transferring or mixing fluids, e.g. from vial to syringe
    • A61J1/2003—Accessories used in combination with means for transfer or mixing of fluids, e.g. for activating fluid flow, separating fluids, filtering fluid or venting
    • A61J1/202—Separating means
    • A61J1/2037—Separating means having valve means
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
    • Y10T137/00—Fluid handling
    • Y10T137/8593—Systems

Definitions

  • the present invention generally relates to a fluid transfer device and, in at least one embodiment, relates to a fluid transfer device for transferring fluid from a sealed container such as a vial to a sealed fluid delivery device such as an ambulatory drug delivery device.
  • injectable drug delivery devices A wide range of injectable drug delivery devices are known in which a fluid medicament, such as insulin, is stored in an expandable-contractible reservoir. In such devices, the fluid is delivered to the patient from the reservoir by forcing the reservoir to contract.
  • injectable is meant to encompass subcutaneous, intradermal, intravenous and intramuscular delivery.
  • Such devices can be filled by the manufacturer of the fluid delivery device or such devices can be filled by a pharmacist, a physician or a patient prior to use. If filled by the manufacturer, it may be difficult to provide the required drug stability in the device since the fluid may be stored from several weeks to a number of years and the fluid delivery device manufacturer must then be responsible for providing the required fluid. If filled by someone downstream, it is difficult for such a person to ensure that the fluid has completely filled the reservoir, i.e. that the reservoir and fluid path do not contain any undesirable air bubbles.
  • this requires priming the device by filling it in a certain orientation which ensures that the air is pushed ahead of the fluid, such as with the filling inlet at the bottom and the delivery outlet at the top (to allow the air to be displaced during filling). Also, transferring fluid from one container to another typically results in at least some wasted fluid.
  • a fluid transfer device for transferring fluid between a supply reservoir and a fill reservoir, comprises a metering reservoir, a first flow path having a first one-way channel fluidly connected with the metering reservoir and configured to fluidly couple the supply reservoir and the metering reservoir and a second one-way channel fluidly connected with the metering reservoir and configured to fluidly couple the fill reservoir and the metering reservoir, and a second flow path configured to fluidly couple the supply reservoir and the fill reservoir.
  • the first one-way channel includes a first cannula and the second one-way channel includes a second cannula.
  • the first cannula includes a beveled tip.
  • the second cannula includes a beveled tip.
  • the fluid transfer device comprises a member supporting the first and second cannulas, the first cannula extending in a first direction from the member and the second cannula extending in a second direction from the member, the first direction being generally opposite the second direction.
  • the metering reservoir extends from the member generally in the first direction.
  • the fluid transfer device comprises a manifold that supports the first and second cannulas, the manifold forming at least part of the first one-way channel and at least part of the second one-way channel.
  • the first cannula has a larger cross sectional area than a cross sectional area of the second cannula.
  • the fluid transfer device comprises a supply support configured to couple the fluid transfer device with the supply reservoir.
  • the supply support includes at least one catch proximate the first channel and configured to releasably retain the supply reservoir.
  • the at least one catch includes at least two catches spaced different distances from the first channel.
  • the supply support includes at least one catch proximate the first channel and configured to non-releasably retain the supply reservoir.
  • the supply support is configured to position the first one-way channel within the supply reservoir and the first one-way channel is configured to transfer substantially all of the fluid from the supply reservoir.
  • the fluid transfer device comprises a member supporting the first and second one-way channels and a tray support connected to the member and configured to align the fill reservoir with the second one-way channel.
  • the fluid transfer device comprises a tray slideably connected to the tray support and configured to accommodate the fill reservoir.
  • at least one of the tray support and the tray further comprises a safety lock configured to prevent the tray from moving relative to the tray body when the tray is empty and exposing the second one-way channel.
  • the fluid transfer device comprises a safety reservoir configured to removeably couple with the tray configured to block access to the second one-way channel in an initial position.
  • the first one-way channel includes a first cannula
  • the second one-way channel includes a second cannula
  • the second flow path includes a third cannula.
  • the third cannula is disposed within the first cannula and a first end of the third cannula is curved toward an inner side wall of the first cannula proximate a distal end of the first cannula.
  • a second end of the third cannula comprises a beveled tip.
  • the second and third cannula extend away from the metering reservoir, the second cannula extending further from the metering reservoir than the third cannula.
  • the metering reservoir includes a plunger.
  • the plunger comprises a plunger rod and a plunger tip.
  • the metering reservoir has a metering stop.
  • the metering stop is adjustable.
  • the volume of the metering reservoir is larger than the volume of the fill reservoir.
  • the volume of the supply reservoir is larger than the volume of the metering reservoir.
  • the second flow path extends partially within the first one-way channel.
  • a distal end of the first one-way channel and a first end of the second flow path are configured to sealingly engage with the supply reservoir and a distal end of the second one-way channel and a second end of the second flow path are each configured to sealingly engage with the fill reservoir.
  • the first and second one-way channels each comprise less than 200 ⁇ l of fluid transfer space.
  • a volume of the first one-way channel is less than a volume of the second one-way channel.
  • the fill reservoir comprises a fluid delivery device and the supply reservoir comprises a vial.
  • a fluid transfer device comprises a metering reservoir, a manifold forming at least part of a first channel, the first channel fluidly connected with the metering reservoir, the first channel comprising a first cannula extending from the manifold, the manifold forming at least part of a second channel, the second channel fluidly connected with the metering reservoir, the second channel comprising a second cannula extending from the manifold, a third channel extending through the manifold and comprising a third cannula having a first end proximate a distal end of the first cannula and a second end proximate a distal end of the second cannula, a first check valve disposed within the first channel, and a second check valve disposed within the second channel.
  • the third cannula extends at least partially through the first cannula and the second cannula extends further from the manifold than the third cannula. In one embodiment, the first cannula is larger than the second cannula.
  • a fluid transfer device comprises a metering reservoir, a first one-way channel fluidly connected with the metering reservoir, and a second one-way channel fluidly connected with the metering reservoir.
  • the first channel includes a first cannula and the second channel includes a second cannula.
  • the first cannula includes a first beveled tip.
  • the first cannula is configured to overcome the surface tension resistance of a fluid within a supply reservoir positioned below the first beveled tip.
  • the second cannula includes a second beveled tip.
  • the fluid transfer device comprises a member supporting the first and second cannulas, the first cannula extending in a first direction from the member and the second cannula extending in a second direction from the member, the first direction being generally opposite the second direction.
  • the metering reservoir extends from the member generally in the first direction.
  • the fluid transfer device comprises a manifold that supports the first and second cannulas, the manifold forming at least part of the first channel and at least part of the second channel.
  • the fluid transfer device comprises a member supporting the first and second channels, and a tray support connected to the member and configured to align a fill reservoir with the second channel.
  • the fluid transfer device comprises a tray slideably connected to the tray support and configured to accommodate the fill reservoir.
  • at least one of the tray support and the tray further comprises a safety lock configured to prevent the tray from moving relative to the tray body when the tray is empty and exposing the second channel.
  • the fluid transfer device comprises a safety reservoir configured to removeably couple with the tray and comprising a penetrable body configured to block access to the second channel in an initial position.
  • the fluid transfer device comprises a third channel having a first end proximate a distal end of the first channel and a second end proximate a distal end of the second channel.
  • the distal end of the first channel and the first end of the third channel are configured to sealingly engage with a supply reservoir and the distal end of the second channel and the second end of the third channel are each configured to sealingly engage with a fill reservoir.
  • the third channel is partially within the first channel.
  • the third channel is at least partially generally coaxial with the first channel.
  • the first end of the third channel is curved toward an inner side wall of the first channel proximate the distal end of the first channel.
  • the first channel includes a first cannula
  • the second channel includes a second cannula
  • the third channel includes a third cannula.
  • the second end of the third cannula comprises a beveled tip.
  • the second and third cannula extend away from the metering reservoir, the second cannula extends further from the metering reservoir than the third cannula channel.
  • the metering reservoir has a volume that is greater than a volume of a fill reservoir configured to be fluidly engaged with the second one-way channel.
  • the fill reservoir comprises a fluid transfer delivery device.
  • the fluid delivery device comprises at least one first catch proximate the first channel and configured to releasably retain a supply reservoir.
  • the fluid delivery device further comprises at least one second catch proximate the first channel, the at least one second catch spaced from the first channel further than the at least one first catch is spaced from the first channel.
  • the metering reservoir includes a plunger.
  • the plunger comprises a plunger rod and a plunger tip.
  • the fluid delivery device comprises a supply support configured to accommodate a supply reservoir proximate the first channel.
  • the metering reservoir has an adjustable metering stop.
  • the first and second channels comprise less than 100 ⁇ l of fluid transfer space. In one embodiment, the first and second channels comprise less than 20 ⁇ l of fluid transfer space.
  • the fluid delivery device comprises an upper support coupled to the first one-way channel, and a lower support coupled to the second one-way channel, the lower support being moveable with respect to upper support, wherein moving the lower support relative to the upper support changes the volume of the metering reservoir.
  • a method of transferring fluid between a supply reservoir and a fill reservoir in a pharmacological system comprises the steps of: fluidly coupling the supply reservoir with the fill reservoir via a sealed flow path; and creating a pressure differential between the supply reservoir and the fill reservoir to draw the fluid through the flow path and into the fill reservoir, wherein the overall volume of each of the fill and supply reservoirs remains constant during fluid transfer.
  • the flow path includes a metering reservoir.
  • the supply reservoir is fluidly connected to the metering reservoir via a first one-way channel and the metering reservoir is fluidly connected to the fill reservoir via a second one-way channel.
  • the method of transferring fluid between a supply reservoir and a fill reservoir in a pharmacological system comprises the steps of: transferring a first volume of fluid from the supply reservoir into the fill reservoir; and transferring a second volume of fluid substantially equal to the first volume of fluid from the fill reservoir into the supply reservoir via a third channel.
  • the pressure differential is created using a manually operable pump, and the method further comprises the steps of: drawing the piston to expand the volume of the metering reservoir and draw the fluid from the fill reservoir through the first channel and into the metering reservoir; and depressing the piston to contract the volume of the metering reservoir to expel the fluid through the second channel and into the fill reservoir.
  • a fluid transfer device comprises a metering reservoir having an adjustable volume, a manifold forming at least part of a first channel, the first channel fluidly connected with the metering reservoir, the first channel comprising a first cannula extending from the manifold, the manifold forming at least part of a second channel, the second channel fluidly connected with the metering reservoir, the second channel comprising a second cannula extending from the manifold, a third channel extending through the manifold and comprising a third cannula having a first end proximate a distal end of the first cannula and a second end proximate a distal end of the second cannula, a first check valve disposed within the first channel, and a second check valve disposed within the second channel.
  • the third cannula extends at least partially through the first cannula and second cannula extends further from the manifold than the third cannula.
  • FIG. 1 a fluid transfer device, generally designated 10, in accordance with an exemplary embodiment of the present invention.
  • the fluid transfer device 10 forms part of a system that generally permits a fluid 12 from a supply reservoir 14 to be transferred to a fill reservoir 16.
  • the supply reservoir 14 and the fill reservoir 16 may be any suitable containers for holding fluids.
  • the fluid transfer device 10 sealingly transfers fluid between two otherwise sealed containers having predetermined volumes.
  • the supply reservoir 14 is a drug vial 28.
  • the fill reservoir 16 is contained within an ambulatory fluid delivery device 24.
  • the fill reservoir 16 is a cartridge that is initially in a retracted position (i.e. filled with air).
  • the fluid transfer device 10 is used in a pharmacological system to transfer fluid containing an active pharmaceutical ingredient (API), such as insulin, from the supply reservoir 14, e.g. a drug vial 28, to a fill reservoir 16, e.g. a drug delivery device 24.
  • API active pharmaceutical ingredient
  • the fluid 12 may be any fluid but in alternative embodiments the fluid 12 may include one or more of the following: GLP1 and analogs, glucagon, oxytocin, somatostatin, fentanyl, morphine, amiodarone, epinephrine, isoproterenol, esmolol, haloperidol, heparin, remicade, lidocaine, vasopressin, antibodies, human growth hormone, erythropoeitin, Avastin®, Tarceva®, follicle stimulating hormone, leutinizing hormone, human chorionic gonadotropin, corticosteroids, antibiotics, antivirals, antifungals or benzodiazepines.
  • GLP1 and analogs glucagon, oxytocin, somatostatin, fentanyl, morphine, amiodarone, epinephrine, isoproterenol, esmolol, ha
  • the supply reservoir 14 is fluidly coupled with the fill reservoir 16 via a first flow path 18.
  • the first flow path 18 is permitted to flow in only one direction.
  • a change in pressure is initially created within the first flow path 18 to pull the fluid 12 from the supply reservoir 14 through the flow path 18 and into the fill reservoir 16.
  • the fill reservoir 16 is provided under positive or negative pressure with respect to atmospheric pressure prior to assembling the system such that fluidly connecting the supply and fill reservoirs 14, 16 causes or assists in the exchange of fluid 12.
  • the overall volumes of the supply and fill reservoirs 14, 16 remain constant during the fluid transfer.
  • the change in pressure is created via a pump 18a connected to or provided within the first flow path 18.
  • the change in pressure is created through the use of a metering reservoir 20 in connection with the first flow path 18.
  • the fluid transfer device 10 forms a closed loop system with the supply reservoir 14 and the fill reservoir 16 such that fluid, either air or overflow liquid displaced from the fill reservoir 16, as described in further detail below, is transferred to the supply reservoir 14 and that the pressure in the supply and fill reservoirs 14, 16 equalizes or balances with each other through at least one of the first and second flow paths 18, 22.
  • a first volume of the fluid 12 is transferred from the supply reservoir 14 into the otherwise sealed fill reservoir 16 and a second volume of the fluid 12 substantially equal to the first volume of the fluid 12 is transferred from the fill reservoir 16 into the otherwise sealed supply reservoir 14 via a second flow path 22.
  • the closed loop system of the fluid transfer device 10 does not include or introduce ambient air in the system other than any air that may exist within the first and second flow paths 18, 22 prior to fluidly connecting the supply and fill reservoirs 14, 16.
  • Such a closed loop system avoids introducing ambient air, which may contain contaminants, into the supply and fill reservoirs 14, 16. Avoiding contact with ambient air is important in certain pharmacological applications where the fluid 12 degrades when in contact with ambient air.
  • the fluid transfer device 10 also reduces the distance the fluid 12 must travel from the supply reservoir 14 to the fill reservoir 16 by minimizing the volume of the first flow path 18. Minimizing the volume of the first flow path 18 reduces mixing the fluid 12 which may result in contaminations, degrading, agitating and/or foaming the fluid 12.
  • Such a closed loop system also prevents wasting the fluid 12 as any overflow liquid 12 in the fill reservoir 16 is recycled back into the supply reservoir 14.
  • the fluid transfer device 10 also reduces the number of steps and devices needed to transfer fluid 12 from one sealed container to another sealed container.
  • the fluid transfer device 10 further allows a user to fill the fill reservoir 16 from the supply reservoir 14 without having to measure the fluid 12.
  • the fluid transfer device 10 is configured for use with differently sized supply and metering reservoirs 14, 16 and in various combinations. In such a system, excess fluid 12 may be provided to ensure the fill reservoir 16 is full regardless of the size of the supply and metering reservoirs 14, 16 with any excess fluid 12 returning back into the supply reservoir 14.
  • the fluid transfer device 10 may further allow an empty supply reservoir 14 to be exchanged with another supply reservoir 14 part-way through filling the fill reservoir 16.
  • the fluid transfer device 10 may also allow a full fill reservoir 16 to be exchanged with an empty fill reservoir 16 part-way through emptying the supply reservoir 14.
  • the fluid transfer device 10 may substantially empty the supply reservoir 14 such that the fluid 12 is not wasted when discarding the used supply reservoir 14.
  • the fluid transfer device 10 may substantially reduce transferring air, ambient air and/or air contained within the system, into the fill reservoir 16.
  • the fill reservoir 16 comprises a fluid delivery device 24.
  • the fluid delivery device 24 may be any known device having an internal cavity, i.e. the fill reservoir 16, to be filled with the fluid 12.
  • the fluid delivery device 24 administers the fluid 12 to a patient (not illustrated).
  • Exemplary fluid delivery devices 24 for use with the fluid transfer device 10 include the devices disclosed in U.S. Patent No. 6,939,324 , U.S. Patent No. 7,481,792 and U.S. Patent No. 7,530,968 , which are hereby incorporated by reference in their entirety.
  • the fill reservoir 16 includes a piercable closure, i.e.
  • the fill reservoir 14 comprises a vial 28.
  • the vial 28 includes a closure 30, including a piercable member 32, such as a septum, on a neck 34.
  • the neck 34 may have a reduced diameter and extends from a vial body 36.
  • the cap 30, neck 34 and vial body 36 are shown to each have a circular cross-section; however, the vial 28 may take any shape such as square and be sealed from the ambient air in any suitable manner to form an air tight cavity.
  • the fluid delivery device 10 includes a member or manifold 38.
  • the manifold 38 may be comprised of first, second and third sections 38a, 38b, 38c.
  • the first fluid flow path 18 is comprised of first and second one-way channels 40, 42.
  • the first one-way channel (first channel) 40 fluidly connects the supply reservoir 14 with the metering reservoir 20.
  • the second one-way channel (second channel) 42 fluidly connects the metering reservoir 20 with the fill reservoir 16.
  • the first channel 40 has a volume less than a volume of the second channel 42. In one embodiment, having the volume of the first channel 40 being less than the volume of the second channel 42 prevents any air that is initially within the first channel 40 from being transferred to the fill reservoir 16 toward the end of delivery.
  • the air that is initially within the first channel 40 may be transferred to the fill reservoir 16 upon filling of a subsequent fill reservoir 16 but the air will be transferred toward the beginning of the fill and will rise to the top of the fill reservoir and be transferred back into the supply reservoir 14 through the third cannula 48.
  • the volumes of the first and second channels 40, 42 are minimized to reduce waste of fluid (e.g. fluid remaining in the first and second channels 40, 42 after the final use).
  • the first and second channels 40, 42 are configured such that the only fluid remaining in the first and second channels 40, 42 after the final use is approximately equal to the difference in volume between the first and second channels 40, 42.
  • the only air within the system may be the air initially in the first and second channels 40, 42, the air initially within the first channel 40 is drawn into the metering chamber 20 and rises to the top of the metering chamber. Once the plunger 74 is depressed, the air initially within the second channel 42 is urged into the empty fill reservoir 16 displacing air back into the supply reservoir 14.
  • the air initially from the first channel 40 that is now in the metering reservoir 20 is urged into the second channel 42. If the volume of the second channel 42 is larger than the volume of the first channel, the air initially within the first channel 40 that is urged into the second channel 42 remains within the second channel 42 without entering the fill reservoir 16 and creating an air bubble trapped in the fill reservoir 16.
  • the length of the first channel 40 is minimized to reduce the time it takes to transfer fluid from the supply reservoir 14 to the metering reservoir 20. In one embodiment, the cross sectional area of the first channel 40 is maximized as discussed above. In one embodiment, the volume of the first channel 40 is approximately 116 ⁇ l. In one embodiment, the volume of the second channel 42 is approximately 125 ⁇ l. In one embodiment, the first and second channels 40, 42 each comprise less than 600 ⁇ l of fluid transfer volume. In one embodiment, the first and second channels 40, 42 each comprise less than 500 ⁇ l of fluid transfer volume. In one embodiment, the first and second channels 40, 42 each comprise less than 400 ⁇ l of fluid transfer volume.
  • the first and second channels 40, 42 each comprise less than 300 ⁇ l of fluid transfer volume. In one embodiment, the first and second channels 40, 42 each comprise less than 200 ⁇ l of fluid transfer volume. In one embodiment, the first and second channels 40, 42 each comprise less than 100 ⁇ l of fluid transfer volume. In one embodiment, the first and second channels 40, 42 each comprise less than 90 ⁇ l of fluid transfer volume. In one embodiment, the first and second channels 40, 42 each comprise less than 80 ⁇ l of fluid transfer volume. In one embodiment, the first and second channels 40, 42 each comprise less than 70 ⁇ l of fluid transfer volume. In one embodiment, the first and second channels 40, 42 each comprise less than 60 ⁇ l of fluid transfer volume.
  • the first and second channels 40, 42 each comprise less than 50 ⁇ l of fluid transfer volume. In one embodiment, the first and second channels 40, 42 each comprise less than 40 ⁇ l of fluid transfer volume. In one embodiment, the first and second channels 40, 42 each comprise less than 30 ⁇ l of fluid transfer volume. In one embodiment, the first and second channels 40, 42 each comprise less than 20 ⁇ l of fluid transfer volume. In one embodiment, the first and second channels 40, 42 each comprise less than 10 ⁇ l of fluid transfer volume.
  • the fluid transfer device 10 including first and second channels 40, 42, are configured to deliver a substantially non-agitating or non-turbulent fluid flow when transferring the fluid 12 from the supply reservoir 14 to the fill reservoir 16.
  • the distal end 44a of the first channel 40 and the first end 48a of the third channel 22 are configured to sealingly engage with a supply reservoir 14 and the distal end 46a of the second channel 42 and the second end 48b of the third channel 22 are each configured to sealingly engage with a fill reservoir 16.
  • the first channel 40 includes a first cannula 44 and the second channel 42 includes a second cannula 46.
  • the second fluid flow path or third channel 22 includes a third cannula 48.
  • the first channel 40 extends from the distal tip 44a of the first cannula 44 to the metering reservoir 20.
  • the second channel 42 extends from the metering reservoir 20 to the distal tip 46a of the second cannula 46.
  • the manifold 38 rigidly supports the first, second and third cannulas 44, 46, 48.
  • the first cannula 44 extends from the first section 38a of the manifold 38 in a first direction and the second cannula 46 extends from the third section 38c of the manifold 38 in a second direction.
  • the first direction is generally opposite the second direction.
  • the metering reservoir 20 extends from the manifold 38 generally in the first direction.
  • the third cannula 48 extends through the manifold 38 and has a first end 48a proximate a distal tip 44a of the first cannula 44 and a second end 48b proximate a distal tip 46b of the second cannula 46.
  • the second cannula 46 extends from the manifold 38 further than the third cannula 48 extends from the manifold 38.
  • the orientation of the supply, transfer and fill reservoirs 14, 20, 16 along with the length of the first and second channels 40, 42 extending in the respective supply and fill reservoirs 14, 16 minimizes and substantially eliminates air within the supply and metering reservoirs 14, 20 from entering the first and second channels 40, 42 and keeps the fluid 14 in the fill reservoir 16 from entering the third channel 22 until the fill reservoir 16 is substantially full. Keeping system air out of the first and second channels 40, 42 reduces foaming and agitation of the liquid 12 within the fill reservoir 16.
  • the size, (e.g. cross sectional area, length and volume) of the first channel, 40, and the second channel, 42, are critical to the speed with which the fluid may be transferred.
  • Restrictive flow through the first channel 40 and first cannula 44 may increase the time required for the fluid to stop flowing into the metering reservoir 20 from the supply reservoir 14.
  • Restrictive flow through the second channel 42 and second cannula 46 may be desired to slow down the transfer from the metering reservoir 20 into the fill reservoir 16.
  • the user must hold the plunger rod 74 ( Fig. 4 ) in the up or transfer position ( Fig. 21 ) until the pressure between the metering reservoir 20 and the supply reservoir 14 is equalized.
  • Releasing the plunger rod 74 prior to the pressure equalizing may result in the plunger rod 74 being pulled into the metering reservoir 20 prior to a full volume of fluid being transferred from the supply reservoir 14 to the metering reservoir 20.
  • the force required to hold the plunger rod 74 in the up position may be proportional to the pressure differential between the supply reservoir 14 and the metering reservoir 20.
  • the user holds the plunger rod 74 in the up or transfer position until the metering reservoir 20 is substantially full and then the user depresses the plunger rod 74 without waiting for the pressure between the supply reservoir 14 and the metering reservoir 20 to equalize.
  • Rapid flow of the fluid 12 into the metering reservoir 20, as the plunger rod 74 is being drawn up, will reduce the force and time required by the user.
  • Restrictive flow of the fluid 12 from the metering reservoir 20, as the plunger rod 74 is being depressed will help the user have control of the transfer of the fluid 12 from the metering reservoir into the fill reservoir 16.
  • the transfer of the fluid 12 from the metering reservoir into the fill reservoir 16 is done drop by drop or in a non-turbulent manner in order to ensure that any air in the system stays toward the top of the fill reservoir 16.
  • the total volume of the second channel 42 is larger than the total volume of the first channel 40 such that any air initially in the first and second channels 40, 42 remains in the metering reservoir and is not transferred into the fill reservoir 16.
  • the second and third cannulas 46, 48 are as small as possible to prevent damage to the closure 16a of the fill reservoir 16 and to reduce or prevent fluid turbulence as described above while allowing sufficient air and fluid transfer from the fill reservoir 16 back into the supply reservoir 14.
  • the second and third cannulas 46, 48 are substantially similar in diameter.
  • the third cannula 48 has a diameter that is at least as large as or larger than the diameter of the second cannula 46.
  • the first cannula 44 has a larger cross sectional area than a cross sectional area of the second cannula 46.
  • the first cannula 44 is a 16 gauge needle.
  • the second and third cannulas 46, 48 are 29 gauge needles.
  • the first cannula 44 is an 8 gauge needle.
  • the first cannula 44 is the largest diameter needle that prevents or reduces coring of the vial septum 32 while keeping in mind that the larger the first channel 40 is the more air that is initially introduced into the system. Any air initially within the first channel 40 may be contained within the second channel 42 by making the second channel 42 larger than the first channel as discussed below. Using the largest diameter needle that prevents or reduces coring of the vial septum may allow for the maximum flow rate between the supply reservoir 14 and the metering reservoir 20 while allowing the supply reservoir 14 to continue functioning as a sealed container following removal of the supply reservoir 14 from the fluid transfer device 10.
  • the first cannula 44 is a 16 gauge needle and the supply reservoir is a 10 ml vial. In another embodiment, the first cannula 44 is configured (e.g. diameter and/or cross sectional area) to give the desired flow rate between the supply reservoir 14 and the metering reservoir 20 without a concern for the resealability of the vial septum 32 if the supply reservoir 14 is to be discarded after removal or the supply reservoir 14 is never removed from the fluid transfer device 10.
  • first, second and third cannulas 44, 46, 48 and the first and second channels 40, 42 are configured (e.g. diameter, cross sectional area and/or length) such that fluid 12 is transferred from the supply reservoir 14 into the metering reservoir in less than 10 seconds. In one embodiment, the first, second and third cannulas 44, 46, 48 and the first and second channels 40, 42 are configured (e.g. diameter, cross sectional area and/or length) such that fluid 12 is transferred from the supply reservoir 14 into the metering reservoir in less than 9 seconds. In one embodiment, the first, second and third cannulas 44, 46, 48 and the first and second channels 40, 42 are configured (e.g.
  • first, second and third cannulas 44, 46, 48 and the first and second channels 40, 42 are configured (e.g. diameter, cross sectional area and/or length) such that fluid 12 is transferred from the supply reservoir 14 into the metering reservoir in less than 7 seconds.
  • first, second and third cannulas 44, 46, 48 and the first and second channels 40, 42 are configured (e.g. diameter, cross sectional area and/or length) such that fluid 12 is transferred from the supply reservoir 14 into the metering reservoir in less than 6 seconds.
  • first, second and third cannulas 44, 46, 48 and the first and second channels 40, 42 are configured (e.g. diameter, cross sectional area and/or length) such that fluid 12 is transferred from the supply reservoir 14 into the metering reservoir in less than 5 seconds. In one embodiment, the first, second and third cannulas 44, 46, 48 and the first and second channels 40, 42 are configured (e.g. diameter, cross sectional area and/or length) such that fluid 12 is transferred from the supply reservoir 14 into the metering reservoir in less than 4 seconds. In one embodiment, the first, second and third cannulas 44, 46, 48 and the first and second channels 40, 42 are configured (e.g.
  • first, second and third cannulas 44, 46, 48 and the first and second channels 40, 42 are configured (e.g. diameter, cross sectional area and/or length) such that fluid 12 is transferred from the supply reservoir 14 into the metering reservoir in less than 2 seconds.
  • first, second and third cannulas 44, 46, 48 and the first and second channels 40, 42 are configured (e.g. diameter, cross sectional area and/or length) such that fluid 12 is transferred from the supply reservoir 14 into the metering reservoir in less than 1 second.
  • the first, second and third cannulas 44, 46, 48 and the first and second channels 40, 42 are configured (e.g. diameter, cross sectional area and/or length) such that fluid 12 is transferred from the supply reservoir 14 into the metering reservoir in less than 0.5 seconds. In one embodiment, the first, second and third cannulas 44, 46, 48 and the first and second channels 40, 42 are configured (e.g. diameter, cross sectional area and/or length) such that fluid 12 is transferred from the supply reservoir 14 into the metering reservoir in less than 0.1 seconds. In one embodiment, the first, second and third cannulas 44, 46, 48 and the first and second channels 40, 42 are sized and configured (e.g. diameter, cross sectional area and/or length) such that fluid 12 is transferred from the supply reservoir 14 into the metering reservoir in less than 0.1 seconds.
  • the distal tip 44a of the first cannula 44 includes a beveled tip for piercing the closure 32 of the supply reservoir 14.
  • the distal tip 46a of the second cannula 46 includes a beveled tip for piercing the septum 16a of the fill reservoir 16.
  • the second end 48b of the third cannula 48 includes a beveled tip for piercing the septum 16a of the fill reservoir 16.
  • the third cannula 48 extends along side of the second cannula 46. In an alternative embodiment, the third cannula 48 is positioned partially within the second cannula 46 (not shown).
  • the third cannula 48 partially extends through or within the first cannula 44. In one embodiment, the third cannula 48 is partially co-axial with the first cannula 44. In another embodiment, the first end 48a of the third cannula 48 is curved toward an inner side wall of the first cannula 44 proximate the distal end 44a of the first cannula 44 such that first end 48a of the third cannula 48 follows an entry path of the first cannula 44 through the septum 32 of the supply reservoir 14 and avoids piercing the septum 32 more than once (e.g. creating a ring shaped piercing).
  • the second cannula 46 extends from the manifold 38 further than the third cannula 48 extends from the manifold 38 such that transferred fluid 12 does not go directly from the second cannula 46 and into the third cannula 48 due to surface tension on the second cannula 46 and pressure differentials between the supply and fill reservoirs 14, 16 without first filling the fill reservoir 16.
  • a ratio of an inner diameter of the first cannula 44 proximate the distal end 44a and an outer diameter of the third cannula 48 proximate the first end 48a is 250:1. In one embodiment, a ratio of an inner diameter of the first cannula 44 proximate the distal end 44a and an outer diameter of the third cannula 48 proximate the first end 48a is 200:1. In one embodiment, a ratio of an inner diameter of the first cannula 44 proximate the distal end 44a and an outer diameter of the third cannula 48 proximate the first end 48a is 150:1.
  • a ratio of an inner diameter of the first cannula 44 proximate the distal end 44a and an outer diameter of the third cannula 48 proximate the first end 48a is 100:1. In one embodiment, a ratio of an inner diameter of the first cannula 44 proximate the distal end 44a and an outer diameter of the third cannula 48 proximate the first end 48a is 50:1. In one embodiment, a ratio of an inner diameter of the first cannula 44 proximate the distal end 44a and an outer diameter of the third cannula 48 proximate the first end 48a is 25:1.
  • a ratio of an inner diameter of the first cannula 44 proximate the distal end 44a and an outer diameter of the third cannula 48 proximate the first end 48a is 20:1. In one embodiment, a ratio of an inner diameter of the first cannula 44 proximate the distal end 44a and an outer diameter of the third cannula 48 proximate the first end 48a is 150:1. In one embodiment, a ratio of an inner diameter of the first cannula 44 proximate the distal end 44a and an outer diameter of the third cannula 48 proximate the first end 48a is 10:1.
  • a ratio of an inner diameter of the first cannula 44 proximate the distal end 44a and an outer diameter of the third cannula 48 proximate the first end 48a is 5:1. In one embodiment, a ratio of an inner diameter of the first cannula 44 proximate the distal end 44a and an outer diameter of the third cannula 48 proximate the first end 48a is 2.5:1. In one embodiment, a ratio of an inner diameter of the first cannula 44 proximate the distal end 44a and an outer diameter of the third cannula 48 proximate the first end 48a is 2.4:1.
  • a ratio of an inner diameter of the first cannula 44 proximate the distal end 44a and an outer diameter of the third cannula 48 proximate the first end 48a is 2.3:1. In one embodiment, a ratio of an inner diameter of the first cannula 44 proximate the distal end 44a and an outer diameter of the third cannula 48 proximate the first end 48a is 2.2:1. In one embodiment, a ratio of an inner diameter of the first cannula 44 proximate the distal end 44a and an outer diameter of the third cannula 48 proximate the first end 48a is 2.1:1.
  • a ratio of an inner diameter of the first cannula 44 proximate the distal end 44a and an outer diameter of the third cannula 48 proximate the first end 48a is 2.0:1. In one embodiment, a ratio of an inner diameter of the first cannula 44 proximate the distal end 44a and an outer diameter of the third cannula 48 proximate the first end 48a is 1.9:1. In one embodiment, a ratio of an inner diameter of the first cannula 44 proximate the distal end 44a and an outer diameter of the third cannula 48 proximate the first end 48a is 1.8:1.
  • a ratio of an inner diameter of the first cannula 44 proximate the distal end 44a and an outer diameter of the third cannula 48 proximate the first end 48a is 1.7:1. In one embodiment, a ratio of an inner diameter of the first cannula 44 proximate the distal end 44a and an outer diameter of the third cannula 48 proximate the first end 48a is 1.6:1. In one embodiment, a ratio of an inner diameter of the first cannula 44 proximate the distal end 44a and an outer diameter of the third cannula 48 proximate the first end 48a is 1.5:1.
  • a ratio of an inner diameter of the first cannula 44 proximate the distal end 44a and an outer diameter of the third cannula 48 proximate the first end 48a is 1.4:1. In one embodiment, a ratio of an inner diameter of the first cannula 44 proximate the distal end 44a and an outer diameter of the third cannula 48 proximate the first end 48a is 1.3:1. In one embodiment, a ratio of an inner diameter of the first cannula 44 proximate the distal end 44a and an outer diameter of the third cannula 48 proximate the first end 48a is 1.2:1.
  • a ratio of an inner diameter of the first cannula 44 proximate the distal end 44a and an outer diameter of the third cannula 48 proximate the first end 48a is 1.1:1.
  • the sizes and respective ratios of the first, second and third cannulas 44, 46, 48 may be varied depending on desired flow characteristics and the characteristics and orientation of the supply and fill reservoirs 14, 16.
  • the first channel 40 includes a first check valve 50 to allow the fluid 12 to only flow through the first channel 40 in a single direction, i.e. from the supply reservoir 14 to the metering reservoir 20.
  • the second channel 42 includes a second check valve 52 to allow the fluid 12 to only flow through the second channel 42 in a single direction, i.e. from the metering reservoir 20 to the fill reservoir 16.
  • the first and second check valves 50, 52 are umbrella valves.
  • the first and second check valves 50, 52 may be any device or any orientation of the first and second channels 40, 42 that prevents fluid-flow in two directions such as duck-bill valves, cross-slit valves, floating ball valves, membranes or micropumps.
  • first and second channels 40, 42 may include more than one check valve 50, 52 to ensure fluid flow within each first and second channel 40, 42 is in a single direction.
  • first and second check valves 50, 52 may be combined into a single valve (not shown) such as a three way valve.
  • first and second check valves 50', 52' are positioned in the first and second cannulas 44', 46' respectively.
  • first and second cannulas 44', 46' are generally co-axial.
  • first and second cannulas 44', 46' abut or conjoin with the third cannula 48' such that a single sealed entry point is created with the supply and fill reservoirs 14, 16.
  • one or more valves is positioned within the manifold 38' between the first and second cannulas 44' at a first flow path junction 18b' such that the fluid 12 is only permitted to flow from the supply reservoir 14 into the fill reservoir 16 in the first flow path 18.
  • the first and second cannulas 44, 46 are formed by a single cannula (not shown) that contains a three-way valve (not shown) connected to the metering reservoir 20.
  • the single cannula may contain one or more a micropump or MEMS (not shown) within the single cannula.
  • first and second channels 40, 42 do not include valves and the one-way flow within the first and second channels 40, 42 is controlled via the pressure differentials and/or the configuration of the first and second flow paths 18, 22 (not illustrated).
  • one or more of the check valves 50', 52' are provided in either or both of the supply and fill reservoirs 14', 16' rather than in the first and/or second channels 40, 42.
  • the manifold 38 at least partially defines the first and second channels 40, 42.
  • the second section 38b substantially forms the first and second channels 40, 42 extending between the first and second cannulas 44, 46 respectively.
  • the first and second check valves 50, 52 are attached to the second section 38b within the first and second channels 40, 42 respectively.
  • the first and third sections 38a, 38c sandwich the second section 38b and define the remainder of the first and second channels 40, 42.
  • the third cannula 48 is attached to the second section 38b. However, the third cannula 48 may be segmented such that the manifold defines a portion of the third channel 22.
  • the first and second sections 38a, 38b may define a first raceway 54 proximate an upper perimeter of the first and second channels 40, 42 and the second and third sections 38b, 38c may define a second raceway 56 proximate a lower perimeter of the first and second channels 40, 42.
  • the first and second raceways 54, 56 are filled with an adhesive (not visible) to attach the first and third sections 38a, 38c to the second section 38b and form a sealing gasket around the first and second channels 40, 42.
  • the adhesive is a UV curable adhesive such as a LOCTITE® product.
  • the adhesive is inserted into the first and second raceways 54, 56 after stacking the first, second and third sections 38a, 38b, 38c of the manifold 38.
  • the first and second raceways 54, 56 may be filled with any adhesive or sealing substance before or after assembling the manifold 38 and the manifold may alternatively be held together by one or more mechanical fasteners such as a snap fit groove, spot weld and/or ultrasonic weld that does not require adhesive.
  • the fluid transfer device 10 includes a supply support 58 configured to accommodate the supply reservoir 14 proximate the first cannula 44.
  • the supply support 58 is rigidly attached to the first section 38a of the manifold 38.
  • the supply support 58 may alternatively be integrally formed with the manifold 38.
  • the supply support 58 includes at least one opening 60 configured to allow a user to contact the vial body 36 of the supply reservoir 14.
  • the supply support 58 includes two laterally spaced openings 60 such that the supply reservoir 14 can be pinched between two fingers during insertion and removal of the supply reservoir 14.
  • the at least one opening 60 is configured to be generally tangent to the supply reservoir 14 to minimize the tendency to twist the supply reservoir 14 relative to the supply support 58.
  • the supply support 58 includes supply reservoir indicia 58b to indicate where and/or how to insert the supply reservoir 14.
  • the supply support 58 includes fill indicia 58c which illustrates the steps to perform in filling the supply reservoir 16.
  • the supply support 58 includes an adapter 62.
  • the adapter 62 is optionally provided to accommodate and/or support differently sized supply reservoirs 14.
  • the adapter 62 is a sleeve that slides over and snap or compression fits onto the vial 28.
  • the adapter 62 includes arms 62b that snap or compression fit proximate or onto the neck 34.
  • the adapter 62 includes diametrically opposed projections 62a that slide into the openings 60 of the supply support 58 and prevent the adapter 62 from twisting relative to the supply support 58 and block a view of the fluid 12 through the supply support 58 and may aid in removing the adapter 62 from the supply support 58.
  • the fluid transfer device 10 may include a plurality of projections 64 extending in the first direction and spaced around the first cannula 44.
  • the projections 64 may slidingly engage with the closure 30 (see Fig. 3 ) when the supply reservoir 14 is inserted over the distal end 44a of the first cannula 44.
  • at least one of the projections 64 includes a first radially inwardly projecting catch 66 configured to releasably retain the supply reservoir 14 by extending over the closure 30 proximate the neck 34.
  • At least one of the projections includes a second radially inwardly projection catch 68 configured to releasably retain the supply reservoir 14 by extending over the closure 30 proximate the neck 34.
  • the first and second catches 66, 68 are spaced from the manifold 38 different distances such that different sized closures 30 may be accommodated.
  • the first section 38a of the manifold 38 may space the supply reservoir 14 a sufficient distance along the first cannula 44 such that the distal end 44a of the first cannula 44 extends entirely within the supply reservoir 14 in the fill position ( Fig. 20 ).
  • the projections 64 are integrally formed with the manifold 38. Referring to Fig. 10 , in another embodiment, at least one the catches 66', 68' are configured to fixedly retain the supply reservoir 14 such that the user cannot remove the supply reservoir 14 after use covering and protecting the first cannula 44.
  • the first cannula 44 pierces the closure 32 and extends into the supply reservoir 14 in the fill position.
  • the inner diameter of the first cannula 44 is sufficiently sized and positioned such that once the fluid 12 is drained below the bevel of the first cannula 44, the vacuum within the first channel 40 is sufficient to overcome the surface tension resistance of the fluid 12 that exists between the fluid 12 and the inner surface of the supply reservoir 14 to substantially empty the supply reservoir 14 to maximize fluid transfer and prevent wasting the fluid 12.
  • the diameter and position of the first cannula 44 within the supply reservoir 14 is configured to extract at least 90 percent of the fluid 12 from the supply reservoir 14.
  • the diameter and position of the first cannula 44 within the supply reservoir 14 is configured to extract at least 91 percent of the fluid 12 from the supply reservoir 14. In one embodiment, the diameter and position of the first cannula 44 within the supply reservoir 14 is configured to extract at least 92 percent of the fluid 12 from the supply reservoir 14. In one embodiment, the diameter and position of the first cannula 44 within the supply reservoir 14 is configured to extract at least 93 percent of the fluid 12 from the supply reservoir 14. In one embodiment, the diameter and position of the first cannula 44 within the supply reservoir 14 is configured to extract at least 94 percent of the fluid 12 from the supply reservoir 14.
  • the diameter and position of the first cannula 44 within the supply reservoir 14 is configured to extract at least 95 percent of the fluid 12 from the supply reservoir 14. In one embodiment, the diameter and position of the first cannula 44 within the supply reservoir 14 is configured to extract at least 96 percent of the fluid 12 from the supply reservoir 14. In one embodiment, the diameter and position of the first cannula 44 within the supply reservoir 14 is configured to extract at least 97 percent of the fluid 12 from the supply reservoir 14. In one embodiment, the diameter and position of the first cannula 44 within the supply reservoir 14 is configured to extract at least 98 percent of the fluid 12 from the supply reservoir 14.
  • the diameter and position of the first cannula 44 within the supply reservoir 14 is configured to extract at least 98.5 percent of the fluid 12 from the supply reservoir 14. In one embodiment, the diameter and position of the first cannula 44 within the supply reservoir 14 is configured to extract at least 99 percent of the fluid 12 from the supply reservoir 14. In one embodiment, the diameter and position of the first cannula 44 within the supply reservoir 14 is configured to extract at least 99.5 percent of the fluid 12 from the supply reservoir 14. In one embodiment, the diameter and position of the first cannula 44 within the supply reservoir 14 is configured to extract at least 99.9 percent of the fluid 12 from the supply reservoir 14.
  • the diameter and position of the first cannula 44 within the supply reservoir 14 is configured to extract at least 99.99 percent of the fluid 12 from the supply reservoir 14. In one embodiment, the diameter and position of the first cannula 44 within the supply reservoir 14 is configured to extract at least 99.999 percent of the fluid 12 from the supply reservoir 14.
  • the supply support 58 includes at least one viewing window 70 such that the amount of fluid 12 remaining within the supply reservoir 14, or lack of fluid 12 within the supply reservoir 14, can be seen by the user.
  • the viewing window 70 at least partially exposes the neck 34 of the vial 28 such that the user can determine if the supply reservoir 14 is empty.
  • the empty supply reservoir 14 may be exchanged with a full supply reservoir 14 to continue filling the fill reservoir 16.
  • the metering reservoir 20 includes a plunger 72.
  • the metering reservoir 20 may be any device that is configured to exchange the fluid 12 within the system and/or impart a pressure differential.
  • the plunger 72 is manually operable and comprises a plunger rod 74 and a plunger tip 76.
  • the plunger tip 76 is constructed of an elastomeric material that seals the metering reservoir 20 from the ambient air.
  • the plunger rod 74 includes a tab 74a for a user to grip between a thumb 26c and an index finger 26d ( Fig. 19 ).
  • the volume of the metering reservoir 20 is controlled by flexing the metering reservoir 20 (not illustrated).
  • the plunger 72 may be threadably connected to the metering reservoir 20 such that a twisting motion by the user controls the volume of the metering reservoir 20 (not illustrated).
  • the volume of the metering reservoir 20 is controlled by a device such as a mechanically controlled piston activated by a push button, lever or wheel or an electro-mechanical actuating device (not shown).
  • the supply support 58 includes a metering stop 78 that acts as a limit stop for the plunger 72.
  • the metering stop 78 is adjustable such that the predetermined volume of the metering reservoir 20 is adjustable.
  • the metering reservoir 20 has a maximum volume that is greater than the volume of the fill reservoir 16.
  • the supply reservoir 14 has a volume greater the maximum volume of the metering reservoir 20.
  • the maximum volume of the metering reservoir 20 is up to 50% greater than the volume of the fill reservoir 16.
  • the maximum volume of the metering reservoir 20 is up to 40% greater than the volume of the fill reservoir 16.
  • the maximum volume of the metering reservoir 20 is up to 30% greater than the volume of the fill reservoir 16.
  • the maximum volume of the metering reservoir 20 is up to 20% greater than the volume of the fill reservoir 16. In one embodiment, the maximum volume of the metering reservoir 20 is up to 10% greater than the volume of the fill reservoir 16. In one embodiment, the maximum volume of the metering reservoir 20 is up to 5% greater than the volume of the fill reservoir 16.
  • the excess fluid 12 from the fill reservoir 16 delivered to the fill reservoir 16 is delivered back into the supply reservoir 14.
  • the predetermined volume of the metering reservoir 20 is adjusted depending on the volume of the fill reservoir 16, the size of the first and second channels 40, 42 and/or a factor of safety or redundancy to account for air transfer within the system such as may be caused by tilting the fluid transfer device 10 from vertical toward horizontal or any air pre-existing within the first and second channels 40, 42.
  • the metering stop 78 includes projections 78a that extend outwardly and are insertable into recesses 58a in the supply support 58.
  • the plunger rod 74 engages with the metering stop 78 at the limit position to prevent further drawing of the plunger 72.
  • the plunger rod 74 includes a projection 74b that contacts the metering stop 78 at the limit position.
  • the excess fluid 12 from the fill reservoir 16 is not returned back into the supply reservoir 14 but is instead delivered to an overflow chamber (not shown) or permitted to freely drain from the system (not illustrated).
  • the metering reservoir 20 includes an air valve (not shown) that allows for air within the metering reservoir 20 to be expelled from the metering reservoir 20 rather than sent through the second channel 42.
  • the air valve is a wettable membrane that allows air to pass through the air valve but not the fluid 12.
  • the air valve is positioned proximate the top of the metering reservoir 20 to purge any air within the system (e.g. air initially within the first channel 40) before the fluid drawn into the metering reservoir 20 contact the air valve.
  • the fluid transfer device 10 includes a tray support 80 connected to the manifold 38 and that is configured to align the fill reservoir 16 with the second cannula 46.
  • a tray 82 is slideably connected to the tray support 80 and is configured to accommodate the fill reservoir 16 or a fluid delivery device 24 containing the fill reservoir 16.
  • the tray support 80 includes a pair of slide rails 84 (only one slide rail visible).
  • the tray 82 is slideably mounted to the slide rails 84 to allow positioning the tray 82 toward and away from the manifold 38.
  • the tray 82 includes a plurality of projections 82a that contact alternate sides of the rails 84 along the length of each rail 84.
  • the second and third cannulas 46, 48 extend into the tray 82.
  • a cannula guide 82b captures the distal end 46a of the second cannula 46 and the second end 48b of the third cannulas 48b and directs the second and third cannulas 46, 48 into the tray 82 as the tray 82 is slid toward the manifold 38.
  • the cannula guide 82b may also help to prevent damage to the second and third cannulas 46, 48 during assembly and use.
  • the cannula guide 82b is fixedly attached to the tray 82.
  • the cannula guide 82b is integral with the tray 82.
  • a sheath 38d extends downwardly from the manifold 38 at least partially surrounding the second and third cannulas 46, 48.
  • the cannula guide 82b may overlap with the sheath 38d to allow for movement of the tray 82 relative to the manifold 38.
  • the cannula guide 82b is slideably coupled with sheath 38d.
  • the sheath 38d extends over the cannula guide 82b.
  • the cannula guide 82b extends over the sheath 38d (not shown).
  • the cannula guide 82b and the sheath 38d are generally cylindrical.
  • the cannula guide 82b and the sheath 38d have any suitable shape such as triangular or rectangular (not shown).
  • the sheath 38d includes a side opening for molding purposes.
  • the cannula guide 82b may help reduce or prevent the second and third cannulas 46, 48 from bending caused by repeated insertion into septums 16a ( Fig. 22 ) of the fill reservoirs 16.
  • the cannula guide 82b includes at least one non-pierceable tube 82e such that the ends of the second and third cannulas 46, 48 are not dulled by or pierce into the polymeric material of the cannula guide 82b as the tray 82 is moved.
  • the non-pierceable tubes 82e are comprised of metal.
  • the second and third cannulas 46, 48 remain at least partially within the cannula guide 82b after assembly in all positions of the tray 82.
  • a proximal end 82d tapers toward the entrance of the tubes 82e to help direct the second and third cannulas 46, 48 into the tubes 82e during assembly of the fluid transfer device 10.
  • a distal end 82c of the cannula guide 82b may extend into the tray 82 for engagement with the fluid delivery device 24 ( Fig. 12 ).
  • the distal end 82c of the cannula guide 82b is tapered (e.g.
  • the distal end 82c of the cannula guide 82b includes a plurality of axially extending and radially spaced projections.
  • the tray 82 includes a safety lock 94 configured to prevent the tray 82 from moving relative to the tray support 80 when the tray 82 is empty.
  • the safety lock 94 is positioned on the tray support 80.
  • the safety lock 94 prevents exposure of the first and third cannulas 46, 48 when the tray 82 is empty.
  • inserting the fluid delivery device 24 containing the fill reservoir 16 within the tray 82 releases the safety lock 94 and allows the tray 80 to move toward the manifold 38.
  • the safety lock 94 engages with a projection 96 within the tray support 80 in the locked position and pivoting the safety lock 94, by inserting the fluid delivery device 24 containing the fill reservoir 16 in the tray 82, pivots the safety lock 94 off of the projection 96 and unlocks the safety lock 94. In one embodiment, removing the fluid delivery device 24 containing the fill reservoir 16 from the tray 82 reengages the safety lock 94 with the projection 96. In one embodiment, the safety lock 94 is spring biased to the tray 82.
  • the tray support 80 includes a ramp 98.
  • the ramp 98 engages with a biasing member 100 attached to the tray 82.
  • the biasing member 100 is a cantilever arm.
  • the biasing member 100 in the load/unload position ( Fig. 19 ), the biasing member 100 contacts the ramp 98 and is urged upwardly through the tray 82 to lift the fluid delivery device 24 containing the fill reservoir 16, at least partially, from the tray 82 such that a user can grasp and remove the fluid delivery device 24 containing the fill reservoir 16 (not illustrated).
  • the biasing member 100 may be bent downwardly toward the tray support 80 when inserting the fluid delivery device 24 containing the fill reservoir 16.
  • the tray 82 is releasably engaged with the tray support 80 in the load/unload, initial and fill positions such that a resistance force is required to move the tray 82 from the initial and fill positions.
  • the tray 82 includes a release 102 that is releasably engaged with the tray support 80 and extends into recesses 104 in the tray support 80 in the load/unload, initial and fill positions.
  • the tray support 80 is curved outwardly proximate the viewing window 90 to accommodate the fluid delivery device 24 containing the fill reservoir 16 when the biasing member 100 pushes the fluid delivery device 24 containing the fill reservoir 16 from the tray 82 in the load/unload position.
  • the tray support 80 includes a first indent 86 configured to accommodate a first finger 26a of a user.
  • the first indent 86 extends laterally across the tray support 80.
  • the first indent 86 is provided at an angle (not shown).
  • the tray support 80 includes a second indent 88 configured to accommodate a second finger 26b of the user.
  • the first finger 26a is a thumb and the second finger 26b is an index finger such that when the fluid transfer device 10 is gripped by the user as shown in Fig. 19 , the fill reservoir 16 is at least partially visible during filling of the fill reservoir 16.
  • the viewing window 90 may be positioned on each side of the fill reservoir 20.
  • a contrasting marking or background may be provided on the interior of the tray support 80 such that the fluid 12 within the fill reservoir 16 is more easily seen through the viewing window 90.
  • a removable safety reservoir 92 comprising a penetrable body is configured to block access to the second and third cannulas 46, 48 and is provided in the tray 82 in the initial position.
  • the safety reservoir 92 includes indicia 92a that provides instructions to the user such as "remove before use” and “replace after use”.
  • the indicia 92a may include any information such as further instructions or product information (not shown).
  • the safety reservoir 92 is removed from the tray 82 and the fluid delivery device 24 containing the fill reservoir is inserted into the tray 82.
  • the tray 82 is closed to sealingly insert the second and third cannula 46, 48 into the fill reservoir 16.
  • the supply reservoir 14 is inserted over the distal end 44a of the first cannula 44 such that the first cannula 44 and the third cannula 48 sealingly extend into the supply reservoir 14 and at least one of the first and second catches 66, 68 engages the supply reservoir 14.
  • the user grasps the tray support 80 with first and second fingers 26a, 26b and grasps the plunger tab 74a with first and second fingers 26c, 26d ( Fig. 19 ).
  • the user pulls the plunger 72 to expand the metering reservoir 20 creating a negative pressure with respect to the pressure in the supply reservoir 14 drawing fluid 12 from the supply reservoir 14 through the first channel 40 and into the metering reservoir 20 ( Fig. 21 ).
  • the user depresses the plunger 72 or pulls the plunger 72 downwardly to contract the metering reservoir 20 to expel liquid 12 through the second channel 42 and into the fill reservoir 16 ( Fig. 22 ).
  • the air within the fill reservoir 16 is compressed by the fluid 12 entering the fill reservoir 16 and travels through the third channel 22 ( Fig. 2 ) to equalize with the pressure within the supply reservoir 14 ( Fig. 2 ).
  • any additional liquid 12 delivered to the fill reservoir 16 is returned to the supply reservoir 14 via the third channel 22.
  • the supply reservoir 14 is exchanged with another supply reservoir 14 and is used to continue filling the fill reservoir 16.
  • the tray 82 is pulled away from the manifold 38 to extract the second and third cannulas 46, 48 from the fill reservoir 16 and the fluid delivery device 24 containing the fill reservoir 16 is removed from the tray 82 and used in its intended application.
  • the fluid transfer device 10 and the various components described above are comprised of materials that are compatible with the fluid 12.
  • the fluid transfer device 10 is comprised of medical-grade materials.
  • the manifold 38, the plunger tip 76 and the check valves 50, 52 are comprised of one or more medical-grade polymers.
  • the first, second and third cannulas 44, 46, 48 are comprised of stainless steel.
  • a fluid transfer device generally designated 210.
  • the supply and fill reservoirs 214, 216 are moved relative to one another to create the pressure differential between the supply and fill reservoirs 214, 216.
  • the metering reservoir 220 is positioned between the supply and fill reservoirs 214, 216.
  • the fluid transfer device 210 includes an upper support 258 coupled to the supply reservoir 214 and a lower support 259 coupled to the fill reservoir 216.
  • the metering reservoir 220 is comprised of a portion of the upper support 258 and a portion of the lower support 259.
  • the upper support 258 includes a plunger 272 and the lower support 259 includes a body of the metering reservoir 220.
  • the first fluid flow path 218 extends through the metering reservoir 220.
  • the second fluid flow path 222 is flexible and/or extendable to accommodate the change in distance between the initial position ( Fig. 24A ) to the transfer position ( Fig. 24B ) and back to the transferred position ( Fig. 24C ).
  • the upper support 258 partially overlaps the lower support 259 in the initial and transferred positions.
  • first and second valves 250, 252 are provided within the first fluid flow path 218 on opposite sides of the metering reservoir 220 such that fluid only flow from the supply reservoir 214 to the fill reservoir 216.
  • first and second valves 250, 252 are provided within the supply and fill reservoirs 214, 216 respectively (not illustrated).
  • pulling the upper support 258 and the supply reservoir 214 away from the lower support 259 and the fill reservoir 216 expands the volume of the metering reservoir 220 and draws fluid 12 from the supply reservoir 214 into the metering reservoir 220.
  • pushing the upper support 258 and the supply reservoir 214 toward the lower support 259 and the fill reservoir 216 contracts the volume of the metering reservoir 220 and forces the fluid 12 from the metering reservoir 220 into the fill reservoir 216.
  • the first and second valves 250, 252 are configured to permit the one-way fluid flow through the first fluid flow path 218.
  • the upper support 258 and the lower support 259 include a corresponding thread (not visible) positioned between the upper support 258 and the lower support 259 and are configured to twist the upper support 258 relative to the lower support 259 to move the upper support axially toward and away from the lower support 259.
  • the thread or threads have a sufficient pitch and angle to allow the user to rotate upper support 258 relative to the lower support 259 less than a full rotation, e.g. 3 ⁇ 4 rotation, 1 ⁇ 2 rotation, 1 ⁇ 4 rotation, and a sufficient vertical or axial separation.
  • a limit indicator 208 is provided between the upper and lower supports 258, 259 and is configured to provide at least one of an audible and tactile feedback to the user to indicate when the metering reservoir 220 is full and when the metering reservoir 220 has been emptied.
  • first and second indicia 258c are provided on the upper and lower supports 258, 259 to indicate which direction to twist the upper support 258.
  • at least part of the indicia 258c is provided between the upper and lower supports 258, 259 such that the required motion is only visible when applicable.
  • the upper and lower supports 258, 259 are moved relative to one another with a push/pull motion, rather than a twisting motion, to create the pressure differential between the supply and fill reservoirs 314, 316.
EP17195514.9A 2009-05-04 2010-05-04 Dispositif de transfert de fluide Withdrawn EP3292881A1 (fr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US17532909P 2009-05-04 2009-05-04
EP10772721.6A EP2427237B1 (fr) 2009-05-04 2010-05-04 Dispositif de transfert de fluide

Related Parent Applications (1)

Application Number Title Priority Date Filing Date
EP10772721.6A Division EP2427237B1 (fr) 2009-05-04 2010-05-04 Dispositif de transfert de fluide

Publications (1)

Publication Number Publication Date
EP3292881A1 true EP3292881A1 (fr) 2018-03-14

Family

ID=43029520

Family Applications (2)

Application Number Title Priority Date Filing Date
EP17195514.9A Withdrawn EP3292881A1 (fr) 2009-05-04 2010-05-04 Dispositif de transfert de fluide
EP10772721.6A Active EP2427237B1 (fr) 2009-05-04 2010-05-04 Dispositif de transfert de fluide

Family Applications After (1)

Application Number Title Priority Date Filing Date
EP10772721.6A Active EP2427237B1 (fr) 2009-05-04 2010-05-04 Dispositif de transfert de fluide

Country Status (8)

Country Link
US (3) US8667996B2 (fr)
EP (2) EP3292881A1 (fr)
JP (4) JP5645278B2 (fr)
KR (1) KR101715421B1 (fr)
CN (2) CN104287966B (fr)
CA (1) CA2760641C (fr)
ES (1) ES2656488T3 (fr)
WO (1) WO2010129583A1 (fr)

Families Citing this family (60)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7547300B2 (en) 2006-04-12 2009-06-16 Icu Medical, Inc. Vial adaptor for regulating pressure
US7883499B2 (en) 2007-03-09 2011-02-08 Icu Medical, Inc. Vial adaptors and vials for regulating pressure
WO2010022095A1 (fr) 2008-08-20 2010-02-25 Icu Medical, Inc. Adaptateurs de flacons anti-reflux
ES2656488T3 (es) * 2009-05-04 2018-02-27 Valeritas, Inc. Dispositivo de transferencia de fluido
EP3760180A3 (fr) 2009-07-29 2021-01-20 ICU Medical, Inc. Methode du transfert de fluides
USD667946S1 (en) * 2010-05-14 2012-09-25 Valeritas, Inc. Fluid transfer device
GB2486693B (en) 2010-12-22 2016-05-18 Owen Mumford Ltd Autoinjectors and manufacturing systems thereof
US10773863B2 (en) 2011-06-22 2020-09-15 Sartorius Stedim North America Inc. Vessel closures and methods for using and manufacturing same
ES2934668T3 (es) 2011-08-18 2023-02-23 Icu Medical Inc Adaptadores de vial de regulación de presión
JP5584368B2 (ja) * 2011-10-26 2014-09-03 パナソニック株式会社 薬液移注方法及び薬液移注装置
EP4218857A3 (fr) 2011-12-22 2023-10-25 ICU Medical, Inc. Dispostifs de transfert de fluide et procédés d'utilisation
ES2615823T3 (es) 2012-01-13 2017-06-08 Icu Medical, Inc. Adaptadores de vial reguladores de presión y métodos
WO2013136803A1 (fr) * 2012-03-16 2013-09-19 テルモ株式会社 Dispositif d'administration de solution de médicament
JP2013192850A (ja) * 2012-03-22 2013-09-30 Terumo Corp 薬液投与装置
AU2013204180B2 (en) 2012-03-22 2016-07-21 Icu Medical, Inc. Pressure-regulating vial adaptors
EP3552595B1 (fr) 2013-01-23 2023-09-13 ICU Medical, Inc. Adaptateurs pour flacon à régulation de pression
US9089475B2 (en) 2013-01-23 2015-07-28 Icu Medical, Inc. Pressure-regulating vial adaptors
US9237986B2 (en) 2013-03-14 2016-01-19 Carefusion 303, Inc. Vial access cap and syringe with gravity-assisted valve
CA3179530A1 (fr) 2013-07-19 2015-01-22 Icu Medical, Inc. Systemes et procedes de transfert de fluides a pression regulee
CN105682607B (zh) * 2013-09-17 2018-06-12 梅里亚股份有限公司 多腔室、多制剂流体递送系统
CN105934229A (zh) * 2013-11-22 2016-09-07 Icu医学有限公司 流体传输装置及使用方法
ES2805051T3 (es) 2013-11-25 2021-02-10 Icu Medical Inc Procedimientos y sistema para llenar bolsas I.V. con líquido terapéutico
JP6280376B2 (ja) * 2014-01-30 2018-02-14 テルモ株式会社 薬液充填装置
GB201413028D0 (en) * 2014-02-28 2014-09-03 Beyond Twenty Ltd Beyond 5
US9364394B2 (en) * 2014-03-14 2016-06-14 Deka Products Limited Partnership Compounder apparatus
JP6612259B2 (ja) * 2014-04-02 2019-11-27 メルク パテント ゲゼルシャフト ミット ベシュレンクテル ハフツング 流体移送デバイスおよび流体を無菌で移送する方法
AU2015277135B2 (en) 2014-06-20 2020-02-20 Icu Medical, Inc. Pressure-regulating vial adaptors
IL234746A0 (en) * 2014-09-18 2014-11-30 Equashield Medical Ltd Improved needle valve and connectors for use in fluid transfer devices
EP3197524B1 (fr) 2014-09-22 2021-10-27 Becton, Dickinson and Company Plaque ayant des canaux de trajet de fluide d'une seule pièce
US11241529B2 (en) 2015-09-21 2022-02-08 Becton, Dickinson And Company Fluid interconnection scheme between reservoir, pump and filling member
CN105193619A (zh) * 2015-11-09 2015-12-30 成都杰仕德科技有限公司 用于粉针瓶的一体式配药机构及配药方法
AU2016365335B2 (en) 2015-12-04 2021-10-21 Icu Medical, Inc. Systems methods and components for transferring medical fluids
CN105640771A (zh) * 2015-12-22 2016-06-08 成都杰仕德科技有限公司 一种粉针瓶一体式配药装置及配药方法
CN105411850A (zh) * 2015-12-22 2016-03-23 成都杰仕德科技有限公司 粉针瓶一体式配药机构及配药方法
CN105534709A (zh) * 2015-12-22 2016-05-04 成都杰仕德科技有限公司 一种粉针瓶一体式配药机构及配药方法
CN105560057A (zh) * 2015-12-22 2016-05-11 成都杰仕德科技有限公司 粉针瓶一体式配药组件及配药方法
CN105616158A (zh) * 2015-12-22 2016-06-01 成都杰仕德科技有限公司 粉针瓶一体式配药装置及配药方法
CA3012733C (fr) 2016-01-29 2023-09-12 Icu Medical, Inc. Adaptateurs pour flacon de regulation de pression
USD851745S1 (en) 2016-07-19 2019-06-18 Icu Medical, Inc. Medical fluid transfer system
JP7046051B2 (ja) 2016-07-25 2022-04-01 アイシーユー・メディカル・インコーポレーテッド 医療用流体移送モジュールおよびシステムの中の空気バブルをトラップするためのシステムおよびコンポーネント
CA3037577A1 (fr) 2016-09-30 2018-04-05 Icu Medical, Inc. Dispositifs et procedes d'acces a un flacon a regulation de pression
US10440989B2 (en) * 2016-11-11 2019-10-15 Portland Engineering, Inc. E-cigarette vaporizer cartridge filling method and apparatus
KR101811846B1 (ko) * 2017-03-15 2017-12-22 김휘화 안전성을 향상시킨 반자동 주사기
IL269453B2 (en) * 2017-03-24 2024-01-01 Carefusion 303 Inc Automatic drug compounder with hygroscopic organ
US10814062B2 (en) 2017-08-31 2020-10-27 Becton, Dickinson And Company Reservoir with low volume sensor
ES2908660T3 (es) * 2017-10-17 2022-05-03 Hoffmann La Roche Un artículo de llenado y procedimientos para el autollenado de un cartucho
US11577953B2 (en) 2017-11-14 2023-02-14 Sartorius Stedim North America, Inc. System for simultaneous distribution of fluid to multiple vessels and method of using the same
WO2019099406A1 (fr) 2017-11-14 2019-05-23 Sartorius Stedim North America Inc. Ensemble de transfert de fluide avec une jonction ayant de multiples voies de fluide
US11319201B2 (en) 2019-07-23 2022-05-03 Sartorius Stedim North America Inc. System for simultaneous filling of multiple containers
US11691866B2 (en) 2017-11-14 2023-07-04 Sartorius Stedim North America Inc. System for simultaneous distribution of fluid to multiple vessels and method of using the same
CA3101200A1 (fr) * 2018-06-18 2019-12-26 Becton Dickinson and Company Limited Element de percage pour adaptateur de flacon
JP7102547B2 (ja) * 2018-06-21 2022-07-19 ザ プロクター アンド ギャンブル カンパニー ２つ以上の液体の共注入のための一体型分配ノズル及びその使用方法
US10604394B1 (en) 2019-02-07 2020-03-31 Willo 32 Sas Cartridge and a base unit for use in an oral care appliance
US10583949B1 (en) * 2019-03-19 2020-03-10 Credence Engineering, Inc. Machine for filling oil cartridges
US20220296471A1 (en) * 2019-08-23 2022-09-22 Zealand Pharma A/S Adapter for a fluid transfer device
WO2021067134A1 (fr) * 2019-09-30 2021-04-08 Becton, Dickinson And Company Système de remplissage de médicament
US11166490B2 (en) 2019-11-13 2021-11-09 Portland Engineering, Inc. E-cigarette vaporizer device filling system and method
US11590057B2 (en) 2020-04-03 2023-02-28 Icu Medical, Inc. Systems, methods, and components for transferring medical fluids
US11612189B2 (en) * 2021-08-15 2023-03-28 Cnc Packaging Inc. Assembly and apparatus for filling cartridges with a liquid
US11866312B1 (en) * 2023-03-14 2024-01-09 Credence Engineering, Inc. Needle actuator for cartridge filling machine

Citations (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0091310A2 (fr) * 1982-04-06 1983-10-12 Baxter Travenol Laboratories, Inc. Système fermé et procédé pour mélanger deux substances stockées séparément
FR2850015A1 (fr) * 2003-01-22 2004-07-23 Rvp Finance Dispositif pour le transfert d'un liquide entre deux recipients
US6939324B2 (en) 2000-11-30 2005-09-06 Biovalve Technologies, Inc. Fluid delivery and measurement systems and methods
WO2007122209A1 (fr) * 2006-04-24 2007-11-01 Novo Nordisk A/S Système de transfert visant à former une solution de médicament à partir d'un médicament lyophilisé
WO2007147741A1 (fr) * 2006-06-21 2007-12-27 Novo Nordisk A/S Mécanisme de mélange et d'expulsion de médicament à une main
US7530968B2 (en) 2003-04-23 2009-05-12 Valeritas, Inc. Hydraulically actuated pump for long duration medicament administration

Family Cites Families (64)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US9009A (en) * 1852-06-08 Bat-trap
CH557178A (de) 1972-08-10 1974-12-31 Siemens Ag Geraet fuer die zufuehrung von medikamenten.
US4073321A (en) * 1976-03-15 1978-02-14 George Moskowitz Adjustable blocking means for dosage regulation
US4316558A (en) * 1980-01-21 1982-02-23 Kubiak Robert J Apparatus for pipetting diluent into a sealed medical container
US4357971A (en) * 1980-09-19 1982-11-09 Cyberon Corporation Syringe gauging, loading and injection apparatus
US4340048A (en) * 1981-03-28 1982-07-20 Alza Corporation Self-driven hypodermic injector
SE427245B (sv) 1982-01-29 1983-03-21 Sjoenell Goeran Forfarande for blandning av ett emne, t ex cytostatika, forvarat i en med gummiforslutning eller motsvarande forsedd ampull, med ett annat emne, t ex sterilt vatten, likasa forvarat i en med gummiforslutning eller motsv
JPS59500601A (ja) 1982-04-06 1984-04-12 バクスタ−、トラベノ−ル、ラボラトリ−ズ　インコ−ポレイテッド 閉鎖薬剤放出システム
US4411662A (en) * 1982-04-06 1983-10-25 Baxter Travenol Laboratories, Inc. Sterile coupling
US4697622A (en) * 1984-06-01 1987-10-06 Parker Hannifin Corporation Passive filling device
US4640048A (en) 1984-08-06 1987-02-03 Winner Kurt W Window sash assembly
US5074844A (en) * 1986-05-29 1991-12-24 Baxter International Inc. Passive drug delivery system
US4902278A (en) * 1987-02-18 1990-02-20 Ivac Corporation Fluid delivery micropump
US5656032A (en) * 1989-06-16 1997-08-12 Science Incorporated Fluid delivery apparatus and method of making same
US5716343A (en) * 1989-06-16 1998-02-10 Science Incorporated Fluid delivery apparatus
GB8926825D0 (en) * 1989-11-28 1990-01-17 Glaxo Group Ltd Device
US5122116A (en) * 1990-04-24 1992-06-16 Science Incorporated Closed drug delivery system
DE4104649A1 (de) * 1991-02-15 1992-09-03 Deutsche Forsch Luft Raumfahrt Vorrichtung zur injektion eines fluids in einen aufnahmebehaelter
US5329976A (en) * 1991-12-09 1994-07-19 Habley Medical Technology Corporation Syringe-filling and medication mixing dispenser
US6251098B1 (en) * 1992-01-24 2001-06-26 I-Flow, Corp. Fluid container for use with platen pump
US5281198A (en) * 1992-05-04 1994-01-25 Habley Medical Technology Corporation Pharmaceutical component-mixing delivery assembly
US5466220A (en) * 1994-03-08 1995-11-14 Bioject, Inc. Drug vial mixing and transfer device
AU681036B2 (en) * 1994-05-23 1997-08-14 B. Braun Medical, Inc. Formulation preparation device
US5637099A (en) * 1994-06-09 1997-06-10 Durdin; Daniel J. Needle handling apparatus and methods
US5562616A (en) * 1995-03-01 1996-10-08 Habley Medical Technology Corporation Semi-automatic reconstituting system for binary oncolytic pharmaceuticals
WO1996026702A1 (fr) * 1995-03-02 1996-09-06 Novo Nordisk A/S Kit permettant de stocker et de melanger des agents dont un, au moins, est liquide
IL114960A0 (en) * 1995-03-20 1995-12-08 Medimop Medical Projects Ltd Flow control device
US6210361B1 (en) * 1997-08-22 2001-04-03 Deka Products Limited Partnership System for delivering intravenous drugs
US6186982B1 (en) * 1998-05-05 2001-02-13 Elan Corporation, Plc Subcutaneous drug delivery device with improved filling system
US5992691A (en) * 1997-07-07 1999-11-30 Fluid Management Dispensing apparatus for fluid contained in flexible packages
US5957895A (en) 1998-02-20 1999-09-28 Becton Dickinson And Company Low-profile automatic injection device with self-emptying reservoir
AU3050499A (en) 1998-03-23 1999-10-18 Elan Corporation, Plc Drug delivery device
US6164348A (en) * 1998-04-09 2000-12-26 Corrosion Consultants, Inc. Method and arrangement for introducing fluorescent dye into a system to be leak tested
US6641565B1 (en) * 1998-11-13 2003-11-04 Elan Pharma International Limited drug delivery systems and methods
WO2001049361A1 (fr) 2000-01-05 2001-07-12 United States Surgical, A Division Of Tyco Healthcare Group Lp Raccord pour flacon
US6641562B1 (en) * 2000-05-10 2003-11-04 Hps Medical, Inc. Apparatus and method of intravenous fluid infusion
FR2815328B1 (fr) * 2000-10-17 2002-12-20 Biodome Dispositif de connexion entre un recipient et un contenant et ensemble pret a l'emploi comprenant un tel dispositif
DK1695727T3 (da) * 2000-11-09 2008-12-01 Insulet Corp Anordning til transkutan administrering
US6474375B2 (en) * 2001-02-02 2002-11-05 Baxter International Inc. Reconstitution device and method of use
US6685692B2 (en) 2001-03-08 2004-02-03 Abbott Laboratories Drug delivery system
JP3935394B2 (ja) 2001-05-14 2007-06-20 株式会社大塚製薬工場 弾性封止体、その製造方法およびそれを用いた薬剤容器
US6736796B2 (en) * 2001-11-26 2004-05-18 Nili-Med Ltd. Fluid drug delivery device
DK1523355T3 (en) * 2002-07-22 2019-04-23 Becton Dickinson Co PLASTER-LIKE INFUSION DEVICE
US7086431B2 (en) * 2002-12-09 2006-08-08 D'antonio Consultants International, Inc. Injection cartridge filling apparatus
RU2248223C2 (ru) 2002-12-30 2005-03-20 Сухонос Юрий Анатольевич Устройство для введения лекарственных средств
EP1454650B1 (fr) * 2003-03-06 2007-10-10 CSL Behring GmbH Dispositif de transfer, notamment pour des fluides médicaux
US6948522B2 (en) * 2003-06-06 2005-09-27 Baxter International Inc. Reconstitution device and method of use
US20050033232A1 (en) * 2003-08-05 2005-02-10 Kriesel Marshall S. Infusion apparatus with modulated flow control
KR20060099520A (ko) * 2003-10-21 2006-09-19 노보 노르디스크 에이/에스 의료용 피부 장착 장치
US20050215850A1 (en) * 2004-03-29 2005-09-29 Ronnie Klein Syringe pump
FR2869533B1 (fr) * 2004-05-03 2006-07-28 Sedat Sa Seringue pour interventions medicales et necessaire de reconstitution de substances extemporanees comportant une telle seringue
US7398802B2 (en) * 2004-09-02 2008-07-15 Baker James W System for dispensing biological fluids
CN101060871A (zh) * 2004-09-10 2007-10-24 贝克顿·迪金森公司 重配输注装置
EP1757320A1 (fr) 2005-08-25 2007-02-28 Eiholzer, Urs Dispositif d'administration
WO2007053799A2 (fr) * 2005-10-19 2007-05-10 Cd Solutions, Llc Appareil et procede de melange et de transfert de medicaments
AU2007233231B2 (en) * 2006-03-30 2011-02-24 Mannkind Corporation Multi-cartridge fluid delivery device
JP4973661B2 (ja) * 2006-06-19 2012-07-11 ニプロ株式会社 薬液調製用キット
WO2008053462A2 (fr) 2006-10-29 2008-05-08 Shlomo Haimi Dispositif de transfert de fluides
US8382713B2 (en) * 2006-12-11 2013-02-26 Kenergy Scientific, Inc. Drug delivery device and methodology
US20080166292A1 (en) * 2007-01-01 2008-07-10 Medrad, Inc. Pharmaceutical Dosing Method
CN102202636A (zh) 2008-05-30 2011-09-28 优诺医疗有限公司 储器填充装置
DE102008035835B4 (de) 2008-08-02 2015-02-19 Walter Pobitschka Verfahren und Vorrichtung zum Transfer einer Substanz zwischen geschlossenen Systemen
ES2656488T3 (es) * 2009-05-04 2018-02-27 Valeritas, Inc. Dispositivo de transferencia de fluido
JP6230931B2 (ja) 2014-02-20 2017-11-15 三菱重工サーマルシステムズ株式会社 マルチ形空気調和機

Patent Citations (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0091310A2 (fr) * 1982-04-06 1983-10-12 Baxter Travenol Laboratories, Inc. Système fermé et procédé pour mélanger deux substances stockées séparément
US6939324B2 (en) 2000-11-30 2005-09-06 Biovalve Technologies, Inc. Fluid delivery and measurement systems and methods
US7481792B2 (en) 2000-11-30 2009-01-27 Valeritas, Inc. Fluid delivery and measurement systems and methods
FR2850015A1 (fr) * 2003-01-22 2004-07-23 Rvp Finance Dispositif pour le transfert d'un liquide entre deux recipients
US7530968B2 (en) 2003-04-23 2009-05-12 Valeritas, Inc. Hydraulically actuated pump for long duration medicament administration
WO2007122209A1 (fr) * 2006-04-24 2007-11-01 Novo Nordisk A/S Système de transfert visant à former une solution de médicament à partir d'un médicament lyophilisé
WO2007147741A1 (fr) * 2006-06-21 2007-12-27 Novo Nordisk A/S Mécanisme de mélange et d'expulsion de médicament à une main

Also Published As

Publication number Publication date
JP6297110B2 (ja) 2018-03-20
JP2016195924A (ja) 2016-11-24
US9833383B2 (en) 2017-12-05
KR20120026523A (ko) 2012-03-19
EP2427237A1 (fr) 2012-03-14
JP2012525868A (ja) 2012-10-25
CA2760641A1 (fr) 2010-11-11
CN102458516A (zh) 2012-05-16
KR101715421B1 (ko) 2017-03-10
CN104287966A (zh) 2015-01-21
CA2760641C (fr) 2017-04-25
CN104287966B (zh) 2017-03-15
US20140124092A1 (en) 2014-05-08
WO2010129583A1 (fr) 2010-11-11
JP2017000804A (ja) 2017-01-05
JP5645278B2 (ja) 2014-12-24
US20160262983A1 (en) 2016-09-15
US20100276034A1 (en) 2010-11-04
US9376224B2 (en) 2016-06-28
EP2427237A4 (fr) 2014-11-05
EP2427237B1 (fr) 2017-11-08
US8667996B2 (en) 2014-03-11
ES2656488T3 (es) 2018-02-27
JP2014133175A (ja) 2014-07-24
CN102458516B (zh) 2014-06-25

Similar Documents

Publication Publication Date Title
US9833383B2 (en) Fluid transfer device
JP6523499B2 (ja) バイアルを利用する注入メカニズム
CN107427412B (zh) 用于注射器连接器的隔膜固定器
US6228065B1 (en) Displacement activated medical check valve
EP2319477B1 (fr) Dispositif de remplissage d'un conteneur de réservoir flexible dans une chambre à pression négative
EP2747734B1 (fr) Adaptateur de fiole à récupération rapide
EP0796604B1 (fr) Dispositif d'alignement pour seringue
US8545441B2 (en) Injector having a displaceable stopper part
US20120029471A1 (en) Two chamber syringe with locking mechanism
EP0637443A1 (fr) Dispositif d'accès au médicament d'une ampoule
US20160144105A1 (en) Vial transfer and injection apparatus and method
US20100292672A1 (en) Autoflush syringe
US20120234099A1 (en) Drive head for a syringe pump
WO2012006555A1 (fr) Seringue à deux chambres ayant un mécanisme de verrouillage
US8617123B2 (en) Pre-filled active vial having integral plunger assembly
EP2815779A1 (fr) Seringue de melange preremplie et methodes associees
RU2809303C2 (ru) Устройство для пулирования для одного или множества медицинских контейнеров

Legal Events

Date Code Title Description
PUAI Public reference made under article 153(3) epc to a published international application that has entered the european phase

Free format text: ORIGINAL CODE: 0009012

STAA Information on the status of an ep patent application or granted ep patent

Free format text: STATUS: THE APPLICATION HAS BEEN PUBLISHED

AC Divisional application: reference to earlier application

Ref document number: 2427237

Country of ref document: EP

Kind code of ref document: P

AK Designated contracting states

Kind code of ref document: A1

Designated state(s): AL AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LI LT LU LV MC MK MT NL NO PL PT RO SE SI SK SM TR

STAA Information on the status of an ep patent application or granted ep patent

Free format text: STATUS: REQUEST FOR EXAMINATION WAS MADE

17P Request for examination filed

Effective date: 20180710

RBV Designated contracting states (corrected)

Designated state(s): AL AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LI LT LU LV MC MK MT NL NO PL PT RO SE SI SK SM TR

RAP1 Party data changed (applicant data changed or rights of an application transferred)

Owner name: ZEALAND PHARMA A/S

STAA Information on the status of an ep patent application or granted ep patent

Free format text: STATUS: EXAMINATION IS IN PROGRESS

17Q First examination report despatched

Effective date: 20200729

STAA Information on the status of an ep patent application or granted ep patent

Free format text: STATUS: EXAMINATION IS IN PROGRESS

RAP1 Party data changed (applicant data changed or rights of an application transferred)

Owner name: MANNKIND CORPORATION

STAA Information on the status of an ep patent application or granted ep patent

Free format text: STATUS: THE APPLICATION IS DEEMED TO BE WITHDRAWN

18D Application deemed to be withdrawn

Effective date: 20230815