EP3239691A4 - Zellbildgebungsvorrichtung, zellbildgebungsverfahren und probenzelle - Google Patents

Zellbildgebungsvorrichtung, zellbildgebungsverfahren und probenzelle Download PDF

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Publication number
EP3239691A4
EP3239691A4 EP15872299.1A EP15872299A EP3239691A4 EP 3239691 A4 EP3239691 A4 EP 3239691A4 EP 15872299 A EP15872299 A EP 15872299A EP 3239691 A4 EP3239691 A4 EP 3239691A4
Authority
EP
European Patent Office
Prior art keywords
cell
cell imaging
sample
imaging device
imaging method
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
EP15872299.1A
Other languages
English (en)
French (fr)
Other versions
EP3239691A1 (de
EP3239691B1 (de
Inventor
Masakazu Fukuda
Masamichi Tanaka
Yanyan Liu
Ryosuke Fujii
Takumi INUTSUKA
Tomoyuki TSUKAHARA
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Sysmex Corp
Original Assignee
Sysmex Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Sysmex Corp filed Critical Sysmex Corp
Priority to EP21206431.5A priority Critical patent/EP3968004A1/de
Publication of EP3239691A1 publication Critical patent/EP3239691A1/de
Publication of EP3239691A4 publication Critical patent/EP3239691A4/de
Application granted granted Critical
Publication of EP3239691B1 publication Critical patent/EP3239691B1/de
Active legal-status Critical Current
Anticipated expiration legal-status Critical

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Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N15/00—Investigating characteristics of particles; Investigating permeability, pore-volume or surface-area of porous materials
    • G01N15/10—Investigating individual particles
    • G01N15/14—Optical investigation techniques, e.g. flow cytometry
    • G01N15/1468—Optical investigation techniques, e.g. flow cytometry with spatial resolution of the texture or inner structure of the particle
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N15/00—Investigating characteristics of particles; Investigating permeability, pore-volume or surface-area of porous materials
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N15/00—Investigating characteristics of particles; Investigating permeability, pore-volume or surface-area of porous materials
    • G01N15/10—Investigating individual particles
    • G01N15/14—Optical investigation techniques, e.g. flow cytometry
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/01—Arrangements or apparatus for facilitating the optical investigation
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/17—Systems in which incident light is modified in accordance with the properties of the material investigated
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/483—Physical analysis of biological material
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/483—Physical analysis of biological material
    • G01N33/487—Physical analysis of biological material of liquid biological material
    • G01N33/493—Physical analysis of biological material of liquid biological material urine
    • G—PHYSICS
    • G02—OPTICS
    • G02B—OPTICAL ELEMENTS, SYSTEMS OR APPARATUS
    • G02B21/00—Microscopes
    • G02B21/24—Base structure
    • G02B21/26—Stages; Adjusting means therefor
    • G—PHYSICS
    • G02—OPTICS
    • G02B—OPTICAL ELEMENTS, SYSTEMS OR APPARATUS
    • G02B21/00—Microscopes
    • G02B21/24—Base structure
    • G02B21/30—Base structure with heating device
    • G—PHYSICS
    • G02—OPTICS
    • G02B—OPTICAL ELEMENTS, SYSTEMS OR APPARATUS
    • G02B21/00—Microscopes
    • G02B21/36—Microscopes arranged for photographic purposes or projection purposes or digital imaging or video purposes including associated control and data processing arrangements
    • G—PHYSICS
    • G02—OPTICS
    • G02B—OPTICAL ELEMENTS, SYSTEMS OR APPARATUS
    • G02B21/00—Microscopes
    • G02B21/36—Microscopes arranged for photographic purposes or projection purposes or digital imaging or video purposes including associated control and data processing arrangements
    • G02B21/365—Control or image processing arrangements for digital or video microscopes
    • G02B21/367—Control or image processing arrangements for digital or video microscopes providing an output produced by processing a plurality of individual source images, e.g. image tiling, montage, composite images, depth sectioning, image comparison
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B10/00—Other methods or instruments for diagnosis, e.g. instruments for taking a cell sample, for biopsy, for vaccination diagnosis; Sex determination; Ovulation-period determination; Throat striking implements
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01B—MEASURING LENGTH, THICKNESS OR SIMILAR LINEAR DIMENSIONS; MEASURING ANGLES; MEASURING AREAS; MEASURING IRREGULARITIES OF SURFACES OR CONTOURS
    • G01B11/00—Measuring arrangements characterised by the use of optical techniques
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N15/00—Investigating characteristics of particles; Investigating permeability, pore-volume or surface-area of porous materials
    • G01N15/10—Investigating individual particles
    • G01N15/14—Optical investigation techniques, e.g. flow cytometry
    • G01N15/1434—Optical arrangements
    • G01N2015/1452—Adjustment of focus; Alignment

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Physics & Mathematics (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Analytical Chemistry (AREA)
  • General Physics & Mathematics (AREA)
  • Immunology (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Pathology (AREA)
  • Biomedical Technology (AREA)
  • Urology & Nephrology (AREA)
  • Optics & Photonics (AREA)
  • Molecular Biology (AREA)
  • Hematology (AREA)
  • Dispersion Chemistry (AREA)
  • Multimedia (AREA)
  • Medicinal Chemistry (AREA)
  • Biophysics (AREA)
  • Food Science & Technology (AREA)
  • Organic Chemistry (AREA)
  • Zoology (AREA)
  • Biotechnology (AREA)
  • Microbiology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Wood Science & Technology (AREA)
  • Computer Vision & Pattern Recognition (AREA)
  • Cell Biology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Engineering & Computer Science (AREA)
  • Genetics & Genomics (AREA)
  • Investigating Or Analysing Materials By Optical Means (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Microscoopes, Condenser (AREA)
  • Optical Measuring Cells (AREA)
EP15872299.1A 2014-12-26 2015-12-25 Zellbildgebungsvorrichtung, zellbildgebungsverfahren und probenzelle Active EP3239691B1 (de)

Priority Applications (1)

Application Number Priority Date Filing Date Title
EP21206431.5A EP3968004A1 (de) 2014-12-26 2015-12-25 Zellbildgebungsvorrichtung, zellbildgebungsverfahren und probenzelle

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
JP2014265931 2014-12-26
JP2014265984 2014-12-26
PCT/JP2015/006469 WO2016103728A1 (ja) 2014-12-26 2015-12-25 細胞撮像装置、細胞撮像方法及び試料セル

Related Child Applications (1)

Application Number Title Priority Date Filing Date
EP21206431.5A Division EP3968004A1 (de) 2014-12-26 2015-12-25 Zellbildgebungsvorrichtung, zellbildgebungsverfahren und probenzelle

Publications (3)

Publication Number Publication Date
EP3239691A1 EP3239691A1 (de) 2017-11-01
EP3239691A4 true EP3239691A4 (de) 2018-08-22
EP3239691B1 EP3239691B1 (de) 2021-11-17

Family

ID=56149785

Family Applications (2)

Application Number Title Priority Date Filing Date
EP15872299.1A Active EP3239691B1 (de) 2014-12-26 2015-12-25 Zellbildgebungsvorrichtung, zellbildgebungsverfahren und probenzelle
EP21206431.5A Pending EP3968004A1 (de) 2014-12-26 2015-12-25 Zellbildgebungsvorrichtung, zellbildgebungsverfahren und probenzelle

Family Applications After (1)

Application Number Title Priority Date Filing Date
EP21206431.5A Pending EP3968004A1 (de) 2014-12-26 2015-12-25 Zellbildgebungsvorrichtung, zellbildgebungsverfahren und probenzelle

Country Status (6)

Country Link
US (1) US10732168B2 (de)
EP (2) EP3239691B1 (de)
JP (2) JP6268309B2 (de)
CN (2) CN112697792A (de)
AU (1) AU2015369316B2 (de)
WO (1) WO2016103728A1 (de)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP6134348B2 (ja) * 2015-03-31 2017-05-24 シスメックス株式会社 細胞撮像装置及び細胞撮像方法
CN107923920B (zh) * 2015-08-25 2021-07-23 株式会社日立高新技术 自动分析装置和自动分析系统
CN110220843A (zh) * 2018-03-01 2019-09-10 深圳大森智能科技有限公司 血液细胞全自动检测装置
JP7131286B2 (ja) * 2018-10-15 2022-09-06 株式会社島津製作所 画像解析式粒子分析装置
CN113138190A (zh) * 2020-01-17 2021-07-20 苏州迈瑞科技有限公司 尿液样本检测设备和检测方法
CN111175301B (zh) * 2020-03-17 2023-03-31 桂林优利特医疗电子有限公司 一种鞘流显微全厚度流道细胞清晰图像采集方法
US20220299445A1 (en) 2020-08-20 2022-09-22 Cheng-Hao KO Screening Test Paper Reading System

Citations (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6493135B1 (en) * 1998-02-17 2002-12-10 Leica Microsystems Heidelberg Gmbh Temperature regulated microscope
US20040256538A1 (en) * 2000-05-03 2004-12-23 Allen Olson Method and apparatus for pre-focus in a linear array based slide scanner
EP1865354A1 (de) * 2005-03-17 2007-12-12 Hamamatsu Photonics K.K. Mikroskopische bilderfassungseinrichtung
US20090103588A1 (en) * 2006-06-13 2009-04-23 Nikon Corporation Microscope apparatus
US20090206234A1 (en) * 2006-07-12 2009-08-20 Toyo Boseki Kabushiki Kaisha Analyzer and use thereof
US20110134516A1 (en) * 2009-12-03 2011-06-09 Olympus Corporation Microscope system
WO2014109095A1 (ja) * 2013-01-09 2014-07-17 オリンパス株式会社 撮像装置、顕微鏡システム及び撮像方法

Family Cites Families (32)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2874746B2 (ja) 1990-11-22 1999-03-24 シスメックス株式会社 フローイメージングサイトメータにおけるフローセル機構
JP4076249B2 (ja) 1997-09-24 2008-04-16 オリンパス株式会社 自動焦点顕微鏡
JP4085297B2 (ja) 2000-03-07 2008-05-14 東洋紡績株式会社 尿中有形成分分類装置
JP3736278B2 (ja) * 2000-04-12 2006-01-18 松下電器産業株式会社 生化学物質の観察方法
WO2003005005A1 (fr) * 2001-07-03 2003-01-16 Hitachi, Ltd. Procede de mesure optique de prelevement biologique et appareil de mesure optique de prelevement biologique
AU2003231881A1 (en) 2002-05-28 2003-12-12 Autogenomics, Inc. Multi-reagent pack
JP2004146670A (ja) * 2002-10-25 2004-05-20 Riipuru:Kk マスクのパターン位置の誤差測定方法及びこれに使用される露光装置
JP2005221725A (ja) * 2004-02-05 2005-08-18 Olympus Corp 焦点検出方法、自動細胞培養装置用自動焦点検出装置、自動細胞培養装置及び培養容器。
JP2006003653A (ja) * 2004-06-17 2006-01-05 Olympus Corp 生体試料観察システム
JP2006138654A (ja) * 2004-11-10 2006-06-01 A & T Corp 有形成分分析装置および有形成分分析方法
JP5069220B2 (ja) 2005-04-12 2012-11-07 カリパー・ライフ・サイエンシズ・インク． マイクロ流体デバイス用の小型光学検出システム
US7663750B2 (en) * 2005-06-30 2010-02-16 Applied Biosystems, Llc Two-dimensional spectral imaging system
US7718131B2 (en) * 2005-07-06 2010-05-18 Genetix Limited Methods and apparatus for imaging and processing of samples in biological sample containers
JP4773198B2 (ja) 2005-12-22 2011-09-14 シスメックス株式会社 標本撮像装置及びこれを備える標本分析装置
JP2007248501A (ja) 2006-03-13 2007-09-27 Horon:Kk フォーカス調整方法およびフォーカス調整装置
US8586385B2 (en) * 2006-12-28 2013-11-19 Intel Corporation Method and device for biomolecule preparation and detection using magnetic array
JP4257863B2 (ja) * 2007-02-13 2009-04-22 東レエンジニアリング株式会社 自動外観検査装置
US8059336B2 (en) * 2007-05-04 2011-11-15 Aperio Technologies, Inc. Rapid microscope scanner for volume image acquisition
JP2010101959A (ja) * 2008-10-21 2010-05-06 Olympus Corp 顕微鏡装置
EP2411808B1 (de) * 2009-03-24 2015-11-11 Biocept, Inc. Vorrichtungen und verfahren für zellerfassung und -analyse
US20120100538A1 (en) * 2009-03-24 2012-04-26 Biocept, Inc. Devices and methods of cell capture and analysis
JP5254441B2 (ja) 2009-06-03 2013-08-07 株式会社日立ハイテクノロジーズ フロー式粒子画像解析方法及び装置
KR100942195B1 (ko) * 2009-10-14 2010-02-11 주식회사 나노엔텍 형광현미경 및 그 원격제어시스템
KR101423896B1 (ko) * 2009-10-19 2014-07-28 벤타나 메디컬 시스템즈, 인코포레이티드 슬라이드 캐싱을 위한 디바이스 및 방법
JP5471715B2 (ja) * 2010-03-30 2014-04-16 ソニー株式会社 合焦装置、合焦方法、合焦プログラム及び顕微鏡
JP2012013804A (ja) * 2010-06-29 2012-01-19 Sony Corp 画像処理装置、画像処理システム、画像処理方法及びプログラム
JP6235462B2 (ja) * 2011-05-18 2017-11-22 スリーエム イノベイティブ プロパティズ カンパニー 試料処理装置内で材料の選択された体積の存在を検出するためのシステム及び方法
WO2013056415A1 (zh) * 2011-10-18 2013-04-25 长沙高新技术产业开发区爱威科技实业有限公司 样本有形成分分析仪自动检测控制装置及其控制方法
US20140193892A1 (en) 2012-07-25 2014-07-10 Theranos, Inc. Image analysis and measurement of biological samples
JP6134348B2 (ja) * 2015-03-31 2017-05-24 シスメックス株式会社 細胞撮像装置及び細胞撮像方法
AU2016311441B2 (en) * 2015-08-27 2023-06-01 Quidel Corporation Immunoassay test device with two fluid flow paths for detection and differentiation of two or more analytes
JP6134402B1 (ja) * 2016-01-29 2017-05-24 シスメックス株式会社 生体試料撮像装置及び生体試料撮像方法

Patent Citations (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6493135B1 (en) * 1998-02-17 2002-12-10 Leica Microsystems Heidelberg Gmbh Temperature regulated microscope
US20040256538A1 (en) * 2000-05-03 2004-12-23 Allen Olson Method and apparatus for pre-focus in a linear array based slide scanner
EP1865354A1 (de) * 2005-03-17 2007-12-12 Hamamatsu Photonics K.K. Mikroskopische bilderfassungseinrichtung
US20090103588A1 (en) * 2006-06-13 2009-04-23 Nikon Corporation Microscope apparatus
US20090206234A1 (en) * 2006-07-12 2009-08-20 Toyo Boseki Kabushiki Kaisha Analyzer and use thereof
US20110134516A1 (en) * 2009-12-03 2011-06-09 Olympus Corporation Microscope system
WO2014109095A1 (ja) * 2013-01-09 2014-07-17 オリンパス株式会社 撮像装置、顕微鏡システム及び撮像方法
US20150309299A1 (en) * 2013-01-09 2015-10-29 Olympus Corporation Imaging apparatus, microscope system, and imaging method

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
See also references of WO2016103728A1 *

Also Published As

Publication number Publication date
CN107003233B (zh) 2021-02-12
WO2016103728A1 (ja) 2016-06-30
JP2018054633A (ja) 2018-04-05
EP3239691A1 (de) 2017-11-01
CN112697792A (zh) 2021-04-23
AU2015369316A1 (en) 2017-07-13
US10732168B2 (en) 2020-08-04
CN107003233A (zh) 2017-08-01
US20170285000A1 (en) 2017-10-05
JP6268309B2 (ja) 2018-01-24
EP3239691B1 (de) 2021-11-17
JPWO2016103728A1 (ja) 2017-06-22
JP6599965B2 (ja) 2019-10-30
EP3968004A1 (de) 2022-03-16
AU2015369316B2 (en) 2020-11-26

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