EP3128837A1 - A formulation in the form of a suspension for the treatment of blood-sucking parasite - Google Patents
A formulation in the form of a suspension for the treatment of blood-sucking parasiteInfo
- Publication number
- EP3128837A1 EP3128837A1 EP15720897.6A EP15720897A EP3128837A1 EP 3128837 A1 EP3128837 A1 EP 3128837A1 EP 15720897 A EP15720897 A EP 15720897A EP 3128837 A1 EP3128837 A1 EP 3128837A1
- Authority
- EP
- European Patent Office
- Prior art keywords
- suspension solution
- fact
- substances
- tick
- mixtures
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Withdrawn
Links
- 239000000203 mixture Substances 0.000 title claims abstract description 52
- 239000000725 suspension Substances 0.000 title claims abstract description 34
- 244000045947 parasite Species 0.000 title claims abstract description 16
- 238000009472 formulation Methods 0.000 title abstract description 33
- 239000000126 substance Substances 0.000 claims abstract description 42
- 241000545744 Hirudinea Species 0.000 claims abstract description 17
- 239000000020 Nitrocellulose Substances 0.000 claims abstract description 15
- 229920001220 nitrocellulos Polymers 0.000 claims abstract description 15
- 230000000249 desinfective effect Effects 0.000 claims abstract description 13
- 239000000843 powder Substances 0.000 claims abstract description 13
- 239000007787 solid Substances 0.000 claims abstract description 12
- 230000002147 killing effect Effects 0.000 claims abstract description 10
- 239000002904 solvent Substances 0.000 claims abstract description 8
- 150000001875 compounds Chemical class 0.000 claims abstract description 7
- 229920001577 copolymer Polymers 0.000 claims abstract description 7
- 150000001298 alcohols Chemical class 0.000 claims abstract description 5
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims abstract description 5
- RTZKZFJDLAIYFH-UHFFFAOYSA-N Diethyl ether Chemical compound CCOCC RTZKZFJDLAIYFH-UHFFFAOYSA-N 0.000 claims description 40
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 claims description 25
- VYPSYNLAJGMNEJ-UHFFFAOYSA-N silicon dioxide Inorganic materials O=[Si]=O VYPSYNLAJGMNEJ-UHFFFAOYSA-N 0.000 claims description 16
- XEKOWRVHYACXOJ-UHFFFAOYSA-N Ethyl acetate Chemical compound CCOC(C)=O XEKOWRVHYACXOJ-UHFFFAOYSA-N 0.000 claims description 9
- ZCYVEMRRCGMTRW-UHFFFAOYSA-N 7553-56-2 Chemical compound [I] ZCYVEMRRCGMTRW-UHFFFAOYSA-N 0.000 claims description 8
- 229910002012 Aerosil® Inorganic materials 0.000 claims description 8
- 239000011630 iodine Substances 0.000 claims description 8
- 229910052740 iodine Inorganic materials 0.000 claims description 8
- NLKNQRATVPKPDG-UHFFFAOYSA-M potassium iodide Inorganic materials [K+].[I-] NLKNQRATVPKPDG-UHFFFAOYSA-M 0.000 claims description 8
- 239000004615 ingredient Substances 0.000 claims description 7
- 239000000440 bentonite Substances 0.000 claims description 6
- 229910000278 bentonite Inorganic materials 0.000 claims description 6
- SVPXDRXYRYOSEX-UHFFFAOYSA-N bentoquatam Chemical compound O.O=[Si]=O.O=[Al]O[Al]=O SVPXDRXYRYOSEX-UHFFFAOYSA-N 0.000 claims description 6
- YGSDEFSMJLZEOE-UHFFFAOYSA-N salicylic acid Chemical compound OC(=O)C1=CC=CC=C1O YGSDEFSMJLZEOE-UHFFFAOYSA-N 0.000 claims description 6
- FVAUCKIRQBBSSJ-UHFFFAOYSA-M sodium iodide Chemical compound [Na+].[I-] FVAUCKIRQBBSSJ-UHFFFAOYSA-M 0.000 claims description 6
- PNDPGZBMCMUPRI-UHFFFAOYSA-N iodine Chemical compound II PNDPGZBMCMUPRI-UHFFFAOYSA-N 0.000 claims description 5
- KFZMGEQAYNKOFK-UHFFFAOYSA-N Isopropanol Chemical compound CC(C)O KFZMGEQAYNKOFK-UHFFFAOYSA-N 0.000 claims description 4
- LLEMOWNGBBNAJR-UHFFFAOYSA-N biphenyl-2-ol Chemical compound OC1=CC=CC=C1C1=CC=CC=C1 LLEMOWNGBBNAJR-UHFFFAOYSA-N 0.000 claims description 4
- GHMLBKRAJCXXBS-UHFFFAOYSA-N resorcinol Chemical compound OC1=CC=CC(O)=C1 GHMLBKRAJCXXBS-UHFFFAOYSA-N 0.000 claims description 4
- SXRSQZLOMIGNAQ-UHFFFAOYSA-N Glutaraldehyde Chemical compound O=CCCCC=O SXRSQZLOMIGNAQ-UHFFFAOYSA-N 0.000 claims description 3
- BZLVMXJERCGZMT-UHFFFAOYSA-N Methyl tert-butyl ether Chemical compound COC(C)(C)C BZLVMXJERCGZMT-UHFFFAOYSA-N 0.000 claims description 3
- ISWSIDIOOBJBQZ-UHFFFAOYSA-N Phenol Chemical compound OC1=CC=CC=C1 ISWSIDIOOBJBQZ-UHFFFAOYSA-N 0.000 claims description 3
- 239000001506 calcium phosphate Substances 0.000 claims description 3
- 229910000389 calcium phosphate Inorganic materials 0.000 claims description 3
- 235000011010 calcium phosphates Nutrition 0.000 claims description 3
- -1 dialuminosilicates Chemical compound 0.000 claims description 3
- FJKROLUGYXJWQN-UHFFFAOYSA-N papa-hydroxy-benzoic acid Natural products OC(=O)C1=CC=C(O)C=C1 FJKROLUGYXJWQN-UHFFFAOYSA-N 0.000 claims description 3
- 229960004889 salicylic acid Drugs 0.000 claims description 3
- QORWJWZARLRLPR-UHFFFAOYSA-H tricalcium bis(phosphate) Chemical compound [Ca+2].[Ca+2].[Ca+2].[O-]P([O-])([O-])=O.[O-]P([O-])([O-])=O QORWJWZARLRLPR-UHFFFAOYSA-H 0.000 claims description 3
- 229940061334 2-phenylphenol Drugs 0.000 claims description 2
- ZFXMDRXVQKSHRV-UHFFFAOYSA-N 3-methyl-2-propan-2-ylphenol 5-methyl-2-propan-2-ylphenol Chemical compound CC(C)C1=CC=C(C)C=C1O.CC(C)C1=C(C)C=CC=C1O ZFXMDRXVQKSHRV-UHFFFAOYSA-N 0.000 claims description 2
- VTYYLEPIZMXCLO-UHFFFAOYSA-L Calcium carbonate Chemical compound [Ca+2].[O-]C([O-])=O VTYYLEPIZMXCLO-UHFFFAOYSA-L 0.000 claims description 2
- LZZYPRNAOMGNLH-UHFFFAOYSA-M Cetrimonium bromide Chemical compound [Br-].CCCCCCCCCCCCCCCC[N+](C)(C)C LZZYPRNAOMGNLH-UHFFFAOYSA-M 0.000 claims description 2
- FYYHWMGAXLPEAU-UHFFFAOYSA-N Magnesium Chemical compound [Mg] FYYHWMGAXLPEAU-UHFFFAOYSA-N 0.000 claims description 2
- KFSLWBXXFJQRDL-UHFFFAOYSA-N Peracetic acid Chemical compound CC(=O)OO KFSLWBXXFJQRDL-UHFFFAOYSA-N 0.000 claims description 2
- QAOWNCQODCNURD-UHFFFAOYSA-L Sulfate Chemical compound [O-]S([O-])(=O)=O QAOWNCQODCNURD-UHFFFAOYSA-L 0.000 claims description 2
- XEFQLINVKFYRCS-UHFFFAOYSA-N Triclosan Chemical compound OC1=CC(Cl)=CC=C1OC1=CC=C(Cl)C=C1Cl XEFQLINVKFYRCS-UHFFFAOYSA-N 0.000 claims description 2
- WMGSQTMJHBYJMQ-UHFFFAOYSA-N aluminum;magnesium;silicate Chemical compound [Mg+2].[Al+3].[O-][Si]([O-])([O-])[O-] WMGSQTMJHBYJMQ-UHFFFAOYSA-N 0.000 claims description 2
- 229910052586 apatite Inorganic materials 0.000 claims description 2
- 235000012216 bentonite Nutrition 0.000 claims description 2
- CYDRXTMLKJDRQH-UHFFFAOYSA-N benzododecinium Chemical class CCCCCCCCCCCC[N+](C)(C)CC1=CC=CC=C1 CYDRXTMLKJDRQH-UHFFFAOYSA-N 0.000 claims description 2
- KGBXLFKZBHKPEV-UHFFFAOYSA-N boric acid Chemical compound OB(O)O KGBXLFKZBHKPEV-UHFFFAOYSA-N 0.000 claims description 2
- 239000004327 boric acid Substances 0.000 claims description 2
- 239000000378 calcium silicate Substances 0.000 claims description 2
- 229910052918 calcium silicate Inorganic materials 0.000 claims description 2
- OYACROKNLOSFPA-UHFFFAOYSA-N calcium;dioxido(oxo)silane Chemical compound [Ca+2].[O-][Si]([O-])=O OYACROKNLOSFPA-UHFFFAOYSA-N 0.000 claims description 2
- HHSPVTKDOHQBKF-UHFFFAOYSA-J calcium;magnesium;dicarbonate Chemical compound [Mg+2].[Ca+2].[O-]C([O-])=O.[O-]C([O-])=O HHSPVTKDOHQBKF-UHFFFAOYSA-J 0.000 claims description 2
- 229960002798 cetrimide Drugs 0.000 claims description 2
- WDFKMLRRRCGAKS-UHFFFAOYSA-N chloroxine Chemical compound C1=CN=C2C(O)=C(Cl)C=C(Cl)C2=C1 WDFKMLRRRCGAKS-UHFFFAOYSA-N 0.000 claims description 2
- 150000001896 cresols Chemical class 0.000 claims description 2
- SHFGJEQAOUMGJM-UHFFFAOYSA-N dialuminum dipotassium disodium dioxosilane iron(3+) oxocalcium oxomagnesium oxygen(2-) Chemical compound [O--].[O--].[O--].[O--].[O--].[O--].[O--].[O--].[Na+].[Na+].[Al+3].[Al+3].[K+].[K+].[Fe+3].[Fe+3].O=[Mg].O=[Ca].O=[Si]=O SHFGJEQAOUMGJM-UHFFFAOYSA-N 0.000 claims description 2
- 239000010459 dolomite Substances 0.000 claims description 2
- 229910000514 dolomite Inorganic materials 0.000 claims description 2
- BDAGIHXWWSANSR-UHFFFAOYSA-N formic acid Substances OC=O BDAGIHXWWSANSR-UHFFFAOYSA-N 0.000 claims description 2
- 229910052500 inorganic mineral Inorganic materials 0.000 claims description 2
- 229910052809 inorganic oxide Inorganic materials 0.000 claims description 2
- 239000001023 inorganic pigment Substances 0.000 claims description 2
- KNISINYMWONJEQ-UHFFFAOYSA-N iodine;phenol Chemical compound [I].OC1=CC=CC=C1 KNISINYMWONJEQ-UHFFFAOYSA-N 0.000 claims description 2
- NLYAJNPCOHFWQQ-UHFFFAOYSA-N kaolin Chemical compound O.O.O=[Al]O[Si](=O)O[Si](=O)O[Al]=O NLYAJNPCOHFWQQ-UHFFFAOYSA-N 0.000 claims description 2
- 239000011777 magnesium Substances 0.000 claims description 2
- 229910052749 magnesium Inorganic materials 0.000 claims description 2
- ZLNQQNXFFQJAID-UHFFFAOYSA-L magnesium carbonate Chemical compound [Mg+2].[O-]C([O-])=O ZLNQQNXFFQJAID-UHFFFAOYSA-L 0.000 claims description 2
- 239000001095 magnesium carbonate Substances 0.000 claims description 2
- 229910000021 magnesium carbonate Inorganic materials 0.000 claims description 2
- WSFSSNUMVMOOMR-NJFSPNSNSA-N methanone Chemical compound O=[14CH2] WSFSSNUMVMOOMR-NJFSPNSNSA-N 0.000 claims description 2
- 239000011707 mineral Substances 0.000 claims description 2
- 235000010755 mineral Nutrition 0.000 claims description 2
- BDRTVPCFKSUHCJ-UHFFFAOYSA-N molecular hydrogen;potassium Chemical compound [K].[H][H] BDRTVPCFKSUHCJ-UHFFFAOYSA-N 0.000 claims description 2
- 235000010292 orthophenyl phenol Nutrition 0.000 claims description 2
- RARSHUDCJQSEFJ-UHFFFAOYSA-N p-Hydroxypropiophenone Chemical compound CCC(=O)C1=CC=C(O)C=C1 RARSHUDCJQSEFJ-UHFFFAOYSA-N 0.000 claims description 2
- VSIIXMUUUJUKCM-UHFFFAOYSA-D pentacalcium;fluoride;triphosphate Chemical compound [F-].[Ca+2].[Ca+2].[Ca+2].[Ca+2].[Ca+2].[O-]P([O-])([O-])=O.[O-]P([O-])([O-])=O.[O-]P([O-])([O-])=O VSIIXMUUUJUKCM-UHFFFAOYSA-D 0.000 claims description 2
- 239000010451 perlite Substances 0.000 claims description 2
- 235000019362 perlite Nutrition 0.000 claims description 2
- ZWLUXSQADUDCSB-UHFFFAOYSA-N phthalaldehyde Chemical compound O=CC1=CC=CC=C1C=O ZWLUXSQADUDCSB-UHFFFAOYSA-N 0.000 claims description 2
- 229940088417 precipitated calcium carbonate Drugs 0.000 claims description 2
- BDERNNFJNOPAEC-UHFFFAOYSA-N propan-1-ol Chemical compound CCCO BDERNNFJNOPAEC-UHFFFAOYSA-N 0.000 claims description 2
- 239000010453 quartz Substances 0.000 claims description 2
- 150000003839 salts Chemical class 0.000 claims description 2
- 235000009518 sodium iodide Nutrition 0.000 claims description 2
- 229910021653 sulphate ion Inorganic materials 0.000 claims description 2
- 229960003500 triclosan Drugs 0.000 claims description 2
- 239000010455 vermiculite Substances 0.000 claims description 2
- 229910052902 vermiculite Inorganic materials 0.000 claims description 2
- 235000019354 vermiculite Nutrition 0.000 claims description 2
- LRHPLDYGYMQRHN-UHFFFAOYSA-N N-Butanol Chemical compound CCCCO LRHPLDYGYMQRHN-UHFFFAOYSA-N 0.000 claims 2
- ZLMJMSJWJFRBEC-UHFFFAOYSA-N Potassium Chemical compound [K] ZLMJMSJWJFRBEC-UHFFFAOYSA-N 0.000 claims 1
- 150000003863 ammonium salts Chemical class 0.000 claims 1
- 238000004659 sterilization and disinfection Methods 0.000 description 12
- 238000000034 method Methods 0.000 description 8
- 230000008020 evaporation Effects 0.000 description 5
- 238000001704 evaporation Methods 0.000 description 5
- 239000000084 colloidal system Substances 0.000 description 4
- 230000000694 effects Effects 0.000 description 4
- 235000012239 silicon dioxide Nutrition 0.000 description 4
- 239000007788 liquid Substances 0.000 description 3
- 230000000379 polymerizing effect Effects 0.000 description 3
- 239000000377 silicon dioxide Substances 0.000 description 3
- 229910000019 calcium carbonate Inorganic materials 0.000 description 2
- 230000018044 dehydration Effects 0.000 description 2
- 238000006297 dehydration reaction Methods 0.000 description 2
- 239000000945 filler Substances 0.000 description 2
- 210000000936 intestine Anatomy 0.000 description 2
- 238000006116 polymerization reaction Methods 0.000 description 2
- RYHBNJHYFVUHQT-UHFFFAOYSA-N 1,4-Dioxane Chemical compound C1COCCO1 RYHBNJHYFVUHQT-UHFFFAOYSA-N 0.000 description 1
- QTWJRLJHJPIABL-UHFFFAOYSA-N 2-methylphenol;3-methylphenol;4-methylphenol Chemical compound CC1=CC=C(O)C=C1.CC1=CC=CC(O)=C1.CC1=CC=CC=C1O QTWJRLJHJPIABL-UHFFFAOYSA-N 0.000 description 1
- 206010002091 Anaesthesia Diseases 0.000 description 1
- 241001465754 Metazoa Species 0.000 description 1
- 150000001299 aldehydes Chemical class 0.000 description 1
- 238000001949 anaesthesia Methods 0.000 description 1
- 230000037005 anaesthesia Effects 0.000 description 1
- 150000001805 chlorine compounds Chemical class 0.000 description 1
- 229930003836 cresol Natural products 0.000 description 1
- 230000007423 decrease Effects 0.000 description 1
- 208000015181 infectious disease Diseases 0.000 description 1
- 230000007774 longterm Effects 0.000 description 1
- 239000003921 oil Substances 0.000 description 1
- 239000011505 plaster Substances 0.000 description 1
- 150000003242 quaternary ammonium salts Chemical class 0.000 description 1
- 150000004760 silicates Chemical class 0.000 description 1
- 229910052814 silicon oxide Inorganic materials 0.000 description 1
- 230000009295 sperm incapacitation Effects 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01N59/00—Biocides, pest repellants or attractants, or plant growth regulators containing elements or inorganic compounds
- A01N59/12—Iodine, e.g. iodophors; Compounds thereof
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01N31/00—Biocides, pest repellants or attractants, or plant growth regulators containing organic oxygen or sulfur compounds
- A01N31/08—Oxygen or sulfur directly attached to an aromatic ring system
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01N31/00—Biocides, pest repellants or attractants, or plant growth regulators containing organic oxygen or sulfur compounds
- A01N31/08—Oxygen or sulfur directly attached to an aromatic ring system
- A01N31/16—Oxygen or sulfur directly attached to an aromatic ring system with two or more oxygen or sulfur atoms directly attached to the same aromatic ring system
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01N33/00—Biocides, pest repellants or attractants, or plant growth regulators containing organic nitrogen compounds
- A01N33/02—Amines; Quaternary ammonium compounds
- A01N33/12—Quaternary ammonium compounds
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01N35/00—Biocides, pest repellants or attractants, or plant growth regulators containing organic compounds containing a carbon atom having two bonds to hetero atoms with at the most one bond to halogen, e.g. aldehyde radical
- A01N35/02—Biocides, pest repellants or attractants, or plant growth regulators containing organic compounds containing a carbon atom having two bonds to hetero atoms with at the most one bond to halogen, e.g. aldehyde radical containing aliphatically bound aldehyde or keto groups, or thio analogues thereof; Derivatives thereof, e.g. acetals
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01N37/00—Biocides, pest repellants or attractants, or plant growth regulators containing organic compounds containing a carbon atom having three bonds to hetero atoms with at the most two bonds to halogen, e.g. carboxylic acids
- A01N37/16—Biocides, pest repellants or attractants, or plant growth regulators containing organic compounds containing a carbon atom having three bonds to hetero atoms with at the most two bonds to halogen, e.g. carboxylic acids containing the group; Thio analogues thereof
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01N37/00—Biocides, pest repellants or attractants, or plant growth regulators containing organic compounds containing a carbon atom having three bonds to hetero atoms with at the most two bonds to halogen, e.g. carboxylic acids
- A01N37/36—Biocides, pest repellants or attractants, or plant growth regulators containing organic compounds containing a carbon atom having three bonds to hetero atoms with at the most two bonds to halogen, e.g. carboxylic acids containing at least one carboxylic group or a thio analogue, or a derivative thereof, and a singly bound oxygen or sulfur atom attached to the same carbon skeleton, this oxygen or sulfur atom not being a member of a carboxylic group or of a thio analogue, or of a derivative thereof, e.g. hydroxy-carboxylic acids
- A01N37/38—Biocides, pest repellants or attractants, or plant growth regulators containing organic compounds containing a carbon atom having three bonds to hetero atoms with at the most two bonds to halogen, e.g. carboxylic acids containing at least one carboxylic group or a thio analogue, or a derivative thereof, and a singly bound oxygen or sulfur atom attached to the same carbon skeleton, this oxygen or sulfur atom not being a member of a carboxylic group or of a thio analogue, or of a derivative thereof, e.g. hydroxy-carboxylic acids having at least one oxygen or sulfur atom attached to an aromatic ring system
- A01N37/40—Biocides, pest repellants or attractants, or plant growth regulators containing organic compounds containing a carbon atom having three bonds to hetero atoms with at the most two bonds to halogen, e.g. carboxylic acids containing at least one carboxylic group or a thio analogue, or a derivative thereof, and a singly bound oxygen or sulfur atom attached to the same carbon skeleton, this oxygen or sulfur atom not being a member of a carboxylic group or of a thio analogue, or of a derivative thereof, e.g. hydroxy-carboxylic acids having at least one oxygen or sulfur atom attached to an aromatic ring system having at least one carboxylic group or a thio analogue, or a derivative thereof, and one oxygen or sulfur atom attached to the same aromatic ring system
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01N47/00—Biocides, pest repellants or attractants, or plant growth regulators containing organic compounds containing a carbon atom not being member of a ring and having no bond to a carbon or hydrogen atom, e.g. derivatives of carbonic acid
- A01N47/40—Biocides, pest repellants or attractants, or plant growth regulators containing organic compounds containing a carbon atom not being member of a ring and having no bond to a carbon or hydrogen atom, e.g. derivatives of carbonic acid the carbon atom having a double or triple bond to nitrogen, e.g. cyanates, cyanamides
- A01N47/42—Biocides, pest repellants or attractants, or plant growth regulators containing organic compounds containing a carbon atom not being member of a ring and having no bond to a carbon or hydrogen atom, e.g. derivatives of carbonic acid the carbon atom having a double or triple bond to nitrogen, e.g. cyanates, cyanamides containing —N=CX2 groups, e.g. isothiourea
- A01N47/44—Guanidine; Derivatives thereof
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01N59/00—Biocides, pest repellants or attractants, or plant growth regulators containing elements or inorganic compounds
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01N59/00—Biocides, pest repellants or attractants, or plant growth regulators containing elements or inorganic compounds
- A01N59/14—Boron; Compounds thereof
Definitions
- the invention relates to a formulation which contains a suspension solution of substances or their compounds in water, alcohols and other volatile solvents or their mixtures, with the content of acrylate copolymer and/or nitrocellulose for incapacitating, dehydrating, rapid killing and disinfection of a blood-sucking and firmly stuck parasite, i.e. in particular a tick or a leech, and its easy and safe removal from the place of sticking of a host.
- the said formulation can be used for efficient disinfecting of the given parasite itself.
- Formulations or methods used for removing a blood-sucking and firmly stuck parasite, in particular a tick or a leech are usually amateur ones (e.g. by shaking out, tearing off etc.), or lengthy and with locally limited usability (e.g. a plaster with a disinfection formulation which is hard-to-be-applied in body folders, hair etc., which are commonly the most frequently occurring places of sticking for a tick).
- This "amateur" method may result in residues of the removed parasite remaining in the place of sticking, which may consequently result in the importation of infection into the host's body.
- One of the other known methods for removing a stuck tick is its removal by means of a special card with slots without prior application of any formulations on the place of sticking.
- the attached special card firmly catches hold of the tick and pulls it out without squeezing the tick and pushing out the content of its intestines into the wound.
- user instructions 2 being attached to the card, it is problematic whether the removing person is skilful enough to remove it without problems, in particular at parts of the body which are difficult to reach.
- Another common method is applying an oil or any fat on the place with the tick, when the greased tick is stifled and consequently removed. There is a high risk in this method that the content of tick's intestines can be thrown out directly to the host's wound before its death.
- Another solution for removing a tick is using alcohol, water- alcohol and other solutions of iodine and/or its compounds with the addition of suitable substances which are able to polymerize.
- a disinfection solution modified in this way a many times higher quantity of an active disinfection substance is applied on the tick as well as on the affected place, and at the same time the formed film of polymerizing substances significantly slows down the evaporation of the solvent and prolongs the contact time of the disinfection substance (still present in the liquid state) with the tick and the skin, which results in prolonging the disinfecting effect.
- the advantage of this method is an easier application on any place of the skin.
- a disadvantage of this application is the fact that after evaporation of volatile substances and completed polymerization, the lodged tick and the surrounding area, where the formulation was applied, remain covered with a dried residue of the formulation which is firmly stuck on the skin and causes problems when removed from the skin.
- the subject-matter of the invention is a formulation containing a suspension solution of substances with disinfecting effect or their compounds in water, alcohols and other volatile solvents or mixtures thereof, with the content of acrylate copolymer and/or nitrocellulose for incapacitating, dehydrating, rapid killing and disinfection of a blood-sucking firmly stuck parasite and its easy removal from the place of sticking of the host, which contains up to 25 % by weight of the powder form of a solid inert substance and/or a mixture of solid inert substances based on the weight of all ingredients of the suspension solution, with the specific area of at least 1 m 2 /g.
- a firmly stuck parasite is preferably a tick or a leech.
- the formulation is a solution of substances with disinfecting effect and moreover, the composition of this formulation contains a powder form of solid inert substances (fillers) and/or mixtures of these solid inert substances, which can be contained up to 25 % by weight based on the weight of all the ingredients of the suspension solution, where their specific area is at least 1 m 2 /g.
- fillers solid inert substances
- mixtures of these solid inert substances which can be contained up to 25 % by weight based on the weight of all the ingredients of the suspension solution, where their specific area is at least 1 m 2 /g.
- the formulation according to the present invention has also strong dehydrating effects which results in all the liquids contained in the tick being absorbed in the applied formulation, which is another cause avoiding the entry of tick's body liquids into the wound.
- the killed, dehydrated and disinfected tick or leech can be easily removed using a pair of tweezers or other suitable manner.
- the suitable design of this invention is the formulation which contains up to 25 w% of the powder form of a solid inert substance, related to the weight of all the ingredients of the suspension solution and or the mixture of solid inert substances with a high specific area (i.e. a low weight in volume), of at least 100 m 2 /g.
- Suitable inert substances according to this invention are powder forms of inert substances, i.e. fine powders of inorganic oxides such as SiCVaerosil, ⁇ 1 2 ⁇ 3, or inorganic pigments such as Ti0 2 , or Si0 2 obtained in the chemical way (usually by pyrohydrolysis from volatile chlorides), a fine ground or precipitated calcium carbonate, magnesium carbonate, calcium- magnesium carbonate - dolomite, dialumino silicates, magnesium dialumosilicates such as magnesium aluminate metasilicate, chalk, talk, calcium phosphate, calcium silicate, bergmeal, mineral powder, quartz powder, porcelain clay, apatite, bentonite, perlite, vermiculite or their mixtures.
- Particularly suitable inert substances are Si0 2 -aerosil, bentonite or powdered Ti0 2 .
- suitable disinfection substances are, in the reasonable quantity, iodine and its compounds (i.e. with potassium iodide or sodium iodide, iodine- povidon, iodine-phenol), and
- aldehydes (formaldehyde, glutaraldehyde, ortho-phthalaldehyde),
- quaternary ammonium salts (benzododecinium salts, carbetopendecinium salts, cetrimide), chlorhexidine digluconate,
- boric acid salicylic acid, peroxo-acetic acid, peroxo-formic acid, potassium hydrogen peroxo sulphate,
- ethanol can be used as a solvent
- diethyl ether contained according to the background art according to the CZ 20342 Ul utility model can be partly or fully replaced with similar, less volatile substances, e.g. propanol or isopropanol and methyl tertiary butyl ether.
- the used solution of nitrocellulose in diethyl ether can be replaced according to this technical solution with a suspension water-alcohol gel with similar effect on incapacitating, dehydrating, disinfection and killing a tick.
- Example 9 A suspension solution containing 37.5 w% of diethyl ether, 36.5 w% of ethanol, 5 w% of nitrocellulose and 1 w% of phenol, containing 20 w% of chemically precipitated CaC0 3
- the tick or the leech were very quickly incapacitated, dehydrated and consequently killed in all of these cases, the tick or the leech as well as the wound were disinfected and the residue of the formulation was easily crumbled away and the tick or the leech easily removed.
- the formulation is intended for the rapid incapacitation, killing and dehydration of a tick and concurrent efficient disinfection of the tick itself.
Landscapes
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Agronomy & Crop Science (AREA)
- Plant Pathology (AREA)
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Dentistry (AREA)
- Wood Science & Technology (AREA)
- Zoology (AREA)
- Environmental Sciences (AREA)
- Pest Control & Pesticides (AREA)
- Inorganic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Agricultural Chemicals And Associated Chemicals (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CZ2014-240A CZ306491B6 (cs) | 2014-04-09 | 2014-04-09 | Prostředek obsahující suspenzní roztok látek s dezinfekčním účinkem pro zneschopnění, dehydrataci, rychlé usmrcení, dezinfekci a jednoduché odstranění krev sajícího a pevně přisátého parazita |
| PCT/CZ2015/000033 WO2015154731A1 (en) | 2014-04-09 | 2015-04-09 | A formulation in the form of a suspension for the treatment of blood-sucking parasite |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| EP3128837A1 true EP3128837A1 (en) | 2017-02-15 |
Family
ID=53054815
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| EP15720897.6A Withdrawn EP3128837A1 (en) | 2014-04-09 | 2015-04-09 | A formulation in the form of a suspension for the treatment of blood-sucking parasite |
Country Status (3)
| Country | Link |
|---|---|
| EP (1) | EP3128837A1 (cs) |
| CZ (1) | CZ306491B6 (cs) |
| WO (1) | WO2015154731A1 (cs) |
Families Citing this family (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN108129547B (zh) * | 2017-11-21 | 2021-01-05 | 齐鲁工业大学 | 一种提取菌胶团胞外聚合物的方法 |
| CN112640913B (zh) * | 2020-12-30 | 2022-02-22 | 佛山市正典生物技术有限公司 | 一种具有长期组分稳定性的含碘消毒剂及其制备方法 |
| CN112806387B (zh) * | 2020-12-31 | 2022-02-25 | 佛山市正典生物技术有限公司 | 一种组分含量稳定的含碘消毒剂的制备方法 |
Family Cites Families (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE10132382A1 (de) * | 2001-07-06 | 2003-02-06 | Stockhausen Chem Fab Gmbh | Verfahren zur Herstellung von desinfizierenden Haut- und Handpflegegelen |
| US20040067247A1 (en) * | 2002-09-27 | 2004-04-08 | Xavier De Sloovere | Composition for combating/repelling insects, birds, dirts and parasites |
| US20040062783A1 (en) * | 2002-09-27 | 2004-04-01 | Xavier De Sloovere | Composition for combating insects and parasites |
| JP4876500B2 (ja) * | 2005-09-22 | 2012-02-15 | 日油株式会社 | ゲル状手指消毒剤 |
| CZ20342U1 (cs) * | 2009-11-05 | 2009-12-07 | Vakos Xt A.S. | Přípravek k rychlému usmrcení klíštěte a účinné dezinfekci místa přisátí na bázi jodu |
| CN102450253A (zh) * | 2010-10-15 | 2012-05-16 | 华北制药集团爱诺有限公司 | 阿维菌素水悬浮剂及其制备方法 |
| JP2013253021A (ja) * | 2012-06-05 | 2013-12-19 | Ikejiri Pharmaceutical Co Ltd | 殺菌消毒剤 |
| CZ27167U1 (cs) * | 2013-11-27 | 2014-07-14 | Vetrisol, S.R.O. | Přípravek k rychlému usmrcení a bezpečnému odstranění přisátého klíštěte |
-
2014
- 2014-04-09 CZ CZ2014-240A patent/CZ306491B6/cs unknown
-
2015
- 2015-04-09 WO PCT/CZ2015/000033 patent/WO2015154731A1/en not_active Ceased
- 2015-04-09 EP EP15720897.6A patent/EP3128837A1/en not_active Withdrawn
Non-Patent Citations (2)
| Title |
|---|
| None * |
| See also references of WO2015154731A1 * |
Also Published As
| Publication number | Publication date |
|---|---|
| CZ2014240A3 (cs) | 2015-10-21 |
| WO2015154731A1 (en) | 2015-10-15 |
| CZ306491B6 (cs) | 2017-02-15 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| AU586243B2 (en) | Antiseptic film forming fluids | |
| EP3128837A1 (en) | A formulation in the form of a suspension for the treatment of blood-sucking parasite | |
| CN106577866A (zh) | 一种精油驱蚊剂 | |
| CN105475370A (zh) | 一种空气消毒剂 | |
| CN106283625B (zh) | 一种用于纺织品的抗菌除臭喷剂 | |
| WO2018030532A1 (ja) | 害虫忌避剤の皮膚への浸透を抑制する方法及び害虫忌避剤の皮膚への浸透抑制剤 | |
| CN106138630A (zh) | 一种医用消毒水 | |
| CN113499389B (zh) | 一种抗菌防螨喷剂及其制备方法和应用 | |
| BR112018073981B1 (pt) | Composição antimicrobiana e uso da composição antimicrobiana | |
| CZ26954U1 (cs) | Prostředek obsahující suspenzní roztok látek s dezinfekčním účinkem pro zneschopnění, dehydrataci, rychlé usmrcení, dezinfekci a jednoduché odstranění krev sajícího a pevně přisátého parazita | |
| JP2006001864A (ja) | 屋内塵性ダニ忌避剤及びこれを用いた屋内塵性ダニ忌避用物品 | |
| BR112021012324A2 (pt) | Composição repelente de pragas do tipo óleo em água | |
| CN102273457A (zh) | 一种萜类空间驱避剂 | |
| JPWO2019189851A1 (ja) | イオン徐放性ガラスを含有するデオドラント組成物 | |
| KR101705815B1 (ko) | 물 없이 사용 가능한 애완동물용 시트형 샴푸 | |
| JPH01245058A (ja) | 樹脂組成物 | |
| CN111479468B (zh) | 凝胶型的人体用害虫驱避剂 | |
| CN112772682A (zh) | 一种环境消毒剂及其制备方法与应用 | |
| JP4247505B2 (ja) | 害虫忌避組成物 | |
| JP2000086408A (ja) | 速乾性手指消毒殺菌剤 | |
| ES2286949B1 (es) | Uso de combinaciones de peroxido de metil etil cetona por pulverizacion. | |
| US20120179085A1 (en) | Device and Process for Creation of Active Antimicrobial Iodine from Inactive Iodine | |
| CN104177948A (zh) | 一种含有龙涎香提取物的长效抗菌乳胶漆 | |
| CZ27167U1 (cs) | Přípravek k rychlému usmrcení a bezpečnému odstranění přisátého klíštěte | |
| CZ31201U1 (cs) | Prostředek na hubení vší |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| PUAI | Public reference made under article 153(3) epc to a published international application that has entered the european phase |
Free format text: ORIGINAL CODE: 0009012 |
|
| 17P | Request for examination filed |
Effective date: 20161107 |
|
| AK | Designated contracting states |
Kind code of ref document: A1 Designated state(s): AL AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LI LT LU LV MC MK MT NL NO PL PT RO RS SE SI SK SM TR |
|
| AX | Request for extension of the european patent |
Extension state: BA ME |
|
| DAV | Request for validation of the european patent (deleted) | ||
| 17Q | First examination report despatched |
Effective date: 20190215 |
|
| STAA | Information on the status of an ep patent application or granted ep patent |
Free format text: STATUS: THE APPLICATION IS DEEMED TO BE WITHDRAWN |
|
| 18D | Application deemed to be withdrawn |
Effective date: 20190626 |