EP3072594A1 - Dispositif et procédé destinés à la détermination du volume d'un liquide - Google Patents

Dispositif et procédé destinés à la détermination du volume d'un liquide Download PDF

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Publication number
EP3072594A1
EP3072594A1 EP15000884.5A EP15000884A EP3072594A1 EP 3072594 A1 EP3072594 A1 EP 3072594A1 EP 15000884 A EP15000884 A EP 15000884A EP 3072594 A1 EP3072594 A1 EP 3072594A1
Authority
EP
European Patent Office
Prior art keywords
liquid
measuring channel
inlet bore
volume
marking
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Withdrawn
Application number
EP15000884.5A
Other languages
German (de)
English (en)
Inventor
Winfried STÖCKER
Daniel Wuttig
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Euroimmun Medizinische Labordiagnostika AG
Original Assignee
Euroimmun Medizinische Labordiagnostika AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Euroimmun Medizinische Labordiagnostika AG filed Critical Euroimmun Medizinische Labordiagnostika AG
Priority to EP15000884.5A priority Critical patent/EP3072594A1/fr
Publication of EP3072594A1 publication Critical patent/EP3072594A1/fr
Withdrawn legal-status Critical Current

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Classifications

    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
    • B01L3/50—Containers for the purpose of retaining a material to be analysed, e.g. test tubes
    • B01L3/502—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures
    • B01L3/5027—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
    • B01L3/02—Burettes; Pipettes
    • B01L3/021—Pipettes, i.e. with only one conduit for withdrawing and redistributing liquids
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01F—MEASURING VOLUME, VOLUME FLOW, MASS FLOW OR LIQUID LEVEL; METERING BY VOLUME
    • G01F22/00—Methods or apparatus for measuring volume of fluids or fluent solid material, not otherwise provided for
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2200/00—Solutions for specific problems relating to chemical or physical laboratory apparatus
    • B01L2200/02—Adapting objects or devices to another
    • B01L2200/026—Fluid interfacing between devices or objects, e.g. connectors, inlet details
    • B01L2200/027—Fluid interfacing between devices or objects, e.g. connectors, inlet details for microfluidic devices
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2200/00—Solutions for specific problems relating to chemical or physical laboratory apparatus
    • B01L2200/06—Fluid handling related problems
    • B01L2200/0605—Metering of fluids
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2200/00—Solutions for specific problems relating to chemical or physical laboratory apparatus
    • B01L2200/14—Process control and prevention of errors
    • B01L2200/143—Quality control, feedback systems
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2200/00—Solutions for specific problems relating to chemical or physical laboratory apparatus
    • B01L2200/14—Process control and prevention of errors
    • B01L2200/148—Specific details about calibrations
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00—Additional constructional details
    • B01L2300/02—Identification, exchange or storage of information
    • B01L2300/025—Displaying results or values with integrated means
    • B01L2300/028—Graduation
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
    • B01L3/50—Containers for the purpose of retaining a material to be analysed, e.g. test tubes
    • B01L3/502—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures
    • B01L3/5027—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip
    • B01L3/502715—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip characterised by interfacing components, e.g. fluidic, electrical, optical or mechanical interfaces

Definitions

  • the present invention relates to a device for determining the volume of a liquid dispensed from or received in a device for the controlled intake and delivery of the liquid with a dispensing orifice, comprising an inlet bore adapted to the dispensing orifice of the device introduced and pressure-locking liquid can be added or discharged, wherein the inlet bore is connected to a measuring channel, so that in the device liquid dispensed penetrates into this device and withdrawing liquid absorbed by the device in this, and wherein the measuring channel has at least one mark and be detected whether the liquid picked up or dispensed reaches the mark; and a method for determining the volume of a liquid which is taken up or delivered by means of a device suitable for controlled uptake and delivery of a liquid, comprising the steps of introducing the liquid-filled device into the inlet bore of the device, pressure-releasing the liquid contained in the device; so that the liquid column penetrates in the measuring channel, and detecting whether the liquid column penetrating in the measuring channel has reached the marking, or comprising
  • the calibration is accomplished by taking with the device a fixed volume of liquid of known density, for example water, which is then weighed. From the weight then results in the volume.
  • a radioactive fluid can be collected and then counted with a scintillation counter.
  • the object underlying the present invention is to provide a device with at least one of the disadvantages the method and apparatus for calibration described above is overcome.
  • a device for calibration should be provided, which in turn need not be calibrated by the user.
  • the calibration should be possible without any calculation steps and the result should be identifiable as possible at a glance, even for personnel without an advanced qualification.
  • the overall process should be feasible with the least possible expenditure of equipment and time.
  • the susceptibility to error and dependence on external conditions such as temperature, humidity and air pressure should be minimized.
  • a device for determining the volume of a liquid which is dispensed from a device for controlled admission and dispensing of the liquid with a dispensing opening comprising an inlet bore, which is adapted to the discharge opening of the device so that it can be introduced and liquid can be taken or discharged from it, wherein the inlet bore is connected to a measuring channel, so that liquid discharged into the device penetrates into this or withdraws liquid absorbed therefrom, and wherein the measuring channel has at least one marking and it can be detected whether liquid penetrating or receding in the measuring channel reaches the marking.
  • the device is designed such that the discharged liquid in the form of a compact liquid column penetrates into the measuring channel or recedes therefrom.
  • the measuring channel is designed in the form of a tube and liquid is present therein in the form of a liquid column filling the vertical average of the measuring channel.
  • the measuring channel opens into an outlet bore.
  • the device is a pipette, preferably filled with a removable pipette tip.
  • the fifth preferred embodiment which is also a preferred embodiment of the first to fourth preferred embodiments, it is visually detected whether the liquid advancing or retreating in the measurement channel reaches the mark.
  • the sixth preferred embodiment which is also a preferred embodiment of the first to fourth preferred embodiments, it is detected by means of a sensor whether the liquid reaches the mark.
  • the inlet bore opens into a reservoir, which is connected to the measuring channel and configured such that only liquid penetrates into the measuring channel, when the sump is completely filled with liquid.
  • the measurement channel has more than one mark.
  • the inlet bore is lined with an elastic material, which is preferably configured in the form of an insert adapted to the shape of the inlet bore.
  • the inlet bore comprises an upper part, the circumference of which exceeds that of the inserted device, preferably in the form of a hemisphere or a section thereof, as well as a lower part, the circumference of which is dimensioned at least at one point so that the vertical insertion of the device is limited.
  • the vertical insertion of the apparatus is limited by placing the discharge opening on a further vertical insertion preventing structure of the inlet bore.
  • the device according to the invention serves to determine the volume which is dispensed from a device for the controlled admission and delivery of a liquid or is taken up by such a device.
  • This device can be any such device, for example, a pump, a laboratory machine or a pipette, preferably a pipette.
  • the dispensed or received volume is preferably variably adjustable within a predetermined range.
  • the device according to the invention comprises a three-dimensional body with an inlet bore, which is designed such that liquid can be dispensed from the device without volume change, in particular without loss of volume, or can be picked up by such a device.
  • the inlet bore is connected to a measuring channel. This can take on any shape and design, provided that the liquid in turn without volume change, in particular without loss of volume, can penetrate therein. It is advantageous if the measuring channel has neither a positive nor a negative slope, but runs horizontally, so that the hydrostatic pressure of the liquid column or gravity does not affect the result.
  • the device is designed so that the liquid can penetrate unhindered or retreat.
  • the displaced volume is discharged via a suitable means, for example, an outlet hole.
  • a suitable means for example, an outlet hole.
  • Such an outlet bore may have a non-pressure-resistant cover to protect against contamination.
  • the device consists of a suitable material with sufficient mechanical and chemical stability, for example plastic, when the liquid is water.
  • the material is transparent, at least insofar as required for optional visual detection of the liquid column.
  • the device may consist of two liquid-tightly connected parts, a planar base plate and a cap having cavities in the form that inlet hole, measuring channel and outlet hole are formed when placing the essay on the planar base plate, the planar base plate the bottom of the inlet bore, Measuring channel and outlet hole represents.
  • Base plate and attachment can be connected by gluing or fasteners, such as a snap-in connector.
  • the measurement channel is provided with at least one mark which allows the operator to determine whether the liquid entering or retreating has reached this mark.
  • the device is designed so that the liquid reaches the mark only if it has a fixed volume.
  • the measuring channel preferably has more than one marking, each of which stands for a specific volume of liquid. This allows the viewer to narrow the volume narrower than would be possible with just one marker.
  • the markers identify the target volume and additionally a tolerance range around the target volume.
  • the target volume is preferably 1 to 5000 ⁇ l, more preferably 10 to 1000 ⁇ l, more preferably 50 to 500 ⁇ l, and the tolerance range is ⁇ 10%, more preferably ⁇ 5%, even more preferably ⁇ 1% of the target volume.
  • the marking runs continuously along at least one linear part of the measuring channel.
  • the type of marking depends on the procedure, in particular on whether liquid is dispensed into the device according to the invention or removed therefrom. For example, if withdrawn, the liquid introduced in the measurement channel will dodge, and the target volume and tolerance range will be located between the inlet bore and the end of the initially introduced liquid column.
  • the term "marking” is to be understood as any embodiment that defines a specific point or area in the measuring channel.
  • it may be a visually perceptible marker, e.g. B. a marking or a succinct form of the measuring channel, which fixes a certain point, such as a meander.
  • the operator can visually, ie by mere observation, determine if the Liquid has penetrated or receded to this point.
  • the marker is preferably chosen so that the volume occupied by the liquid as it enters or retreats to the point indicated by the marker corresponds to the target volume which ideally should be dispensed or picked up by the device.
  • the measuring channel preferably has a narrower diameter than in the region of the markings, more preferably the markings characterizing the target volume and the tolerance range, so that even small differences in volume can be perceived with sufficient resolution on the basis of the markings.
  • the diameter of the measuring channel over the entire distance over which it extends along the planar base plate the same.
  • a compartment serving as a liquid reservoir which comprises at least 50%, preferably at least 75%, more preferably at least 90% of the target volume, may be connected upstream of the measuring channel.
  • the liquid may be any liquid which has suitable properties, in particular with regard to viscosity, volatility and chemical stability, to be transferred with such equipment and to penetrate in the measuring channel in a suitable manner. Most preferably it is a water-based liquid, d. H. the predominant or only solvent in it is water.
  • the fluid may contain additives that aid in detection. If a visual detection is provided, the liquid may have a dye to increase the contrast to the environment, for example an organic dye or a colored inorganic salt.
  • the measuring channel is closed to the outside and arranged inside the device, preferably in the form of a tube with markings. In this way, contamination by dust particles is excluded.
  • it may be an at least partially upwardly open channel on the surface of the calibration device.
  • the device is designed so that the dispensed or withdrawn liquid in the form of a compact liquid column penetrates into the measuring channel or recedes therein.
  • the liquid formed by the liquid does not initially wet the entire bottom of the channel when entering or presenting, and then rises vertically. Rather, it penetrates due to Surface tension and capillary forces in the way in the channel before that, as far as it wets the bottom of the channel, a maximum in the vertical direction, in the case of a tubular channel completely.
  • the type of liquid on the one hand, in particular the hydrophilicity and surface tension, and the diameter and surface area of the channel on the other hand are selected or adapted accordingly. The formation of gas bubbles is to be prevented.
  • a sensor can be used to determine if the liquid reaches one or more than one mark as it advances or retreats in the measurement channel.
  • the term "sensor” as used herein means a means that, due to altered physical quantities, allows the determination, preferably automatic, of whether the liquid column is present or absent at a particular point in the measurement channel. All sensors are suitable which are suitable for detecting the liquid, for example light barriers, ultrasound or refractive index sensors.
  • the inlet bore is preferably designed such that liquid can be dispensed or taken out of the device or the device according to the invention in a pressure-tight manner. It may be lined with an elastic material, for example an elastic plastic such as silicone, which is preferably configured in the form of an insert adapted to the shape of the inlet bore. This allows the device to be inserted into the device with some pressure. This simplifies the pressure completion when dispensing or removing the liquid.
  • an elastic material for example an elastic plastic such as silicone
  • the pressure shut-off can serve, in particular, to ensure that the volume readable by the liquid in the measuring channel is not distorted by the liquid spouting or the aspiration of gas bubbles.
  • the pressure also contributes to the fact that the volume of fluid removed is equal to the volume of liquid contained in the device after recording.
  • the inlet bore comprises an upper part exposing an opening having a diameter exceeding that of the inserted device, preferably in the form of a hemisphere or a cutout therefrom, and a lower part whose opening has a diameter at at least one location is dimensioned that the vertical insertion of the device is limited.
  • the upper part which tapers towards the floor, helps the operator to insert the device.
  • the lower Part fixes the position of the device and thus the accuracy in the volume measurement.
  • the vertical insertion of the device is limited by the fact that the discharge opening of the device during insertion on a further vertical insertion preventing structure of the inlet bore touches, which also consists of a non-deformable material. It particularly includes a channel, so that the position of the device is fixed again, but liquid can be released or received unhindered.
  • the liquid discharged into the device according to the invention or remaining therefrom is advisable to remove the liquid discharged into the device according to the invention or remaining therefrom.
  • This can be done by blowing, preferably via the inlet bore, or applying negative pressure, preferably via the outlet bore, for example by placing a suction hood.
  • the device can be rinsed for cleaning after a calibration, for example with distilled water or a washing liquid.
  • the cleaning-related liquid can also be removed by blowing or suction.
  • a highly volatile liquid such as isopropanol is used for the last wash step.
  • the process according to the invention can be carried out in the form of two variants.
  • the distance over which the liquid moves in the measuring channel corresponds to a certain volume, which can be calculated from the diameter of the measuring channel and the distance. This volume can be compared to the set point value as set in the device by means of the marking.
  • pressure-limiting operation is used in the first and / or second variant.
  • a fixed volume is dispensed from the device into the device according to the invention. It penetrates the measuring channel, and the operator can detect whether the at least one marking is reached by the penetrating liquid column.
  • the marking is designed in such a way that the operator can use this information to recognize whether the device is functioning with sufficient accuracy or not.
  • a known volume of a liquid is presented in the device.
  • the volume may be chosen so that the liquid column reaches into the vicinity of the end of the measuring channel, but not beyond, so that the operator can track the retraction of the liquid column from the beginning.
  • the liquid column preferably extends to the inlet bore, so that it can be removed via this with the aid of the device.
  • the device is introduced into the inlet bore and removed a fixed volume of the liquid, which recedes in the measuring channel. Again, the operator may detect whether the at least one mark is being reached by the advancing liquid column and see if the instrument is operating with sufficient accuracy.

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  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Clinical Laboratory Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Physics & Mathematics (AREA)
  • Fluid Mechanics (AREA)
  • General Physics & Mathematics (AREA)
  • Dispersion Chemistry (AREA)
  • Analytical Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Hematology (AREA)
  • Feeding, Discharge, Calcimining, Fusing, And Gas-Generation Devices (AREA)
EP15000884.5A 2015-03-26 2015-03-26 Dispositif et procédé destinés à la détermination du volume d'un liquide Withdrawn EP3072594A1 (fr)

Priority Applications (1)

Application Number Priority Date Filing Date Title
EP15000884.5A EP3072594A1 (fr) 2015-03-26 2015-03-26 Dispositif et procédé destinés à la détermination du volume d'un liquide

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
EP15000884.5A EP3072594A1 (fr) 2015-03-26 2015-03-26 Dispositif et procédé destinés à la détermination du volume d'un liquide

Publications (1)

Publication Number Publication Date
EP3072594A1 true EP3072594A1 (fr) 2016-09-28

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Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE102017123249A1 (de) * 2017-10-06 2019-04-11 Hamilton Bonaduz Ag Vorrichtung zur Bestimmung des Volumens einer Flüssigkeit
US11602751B2 (en) 2017-03-31 2023-03-14 Forward Biotech, Inc. Liquid evaluation

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3915652A (en) * 1973-08-16 1975-10-28 Samuel Natelson Means for transferring a liquid in a capillary open at both ends to an analyzing system
DE3239820A1 (de) * 1982-10-27 1984-05-03 Ricki Labor Systeme Friederike vom Bauer-Willms, 5657 Haan Vorrichtung zur ueberpruefung von kolbenhubpipetten
US20080066523A1 (en) * 2006-09-19 2008-03-20 Csem Centre Suisse D'electronique Et De Microtechnique Sa Device and method for calibrating a pipette or a dispensing system

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3915652A (en) * 1973-08-16 1975-10-28 Samuel Natelson Means for transferring a liquid in a capillary open at both ends to an analyzing system
DE3239820A1 (de) * 1982-10-27 1984-05-03 Ricki Labor Systeme Friederike vom Bauer-Willms, 5657 Haan Vorrichtung zur ueberpruefung von kolbenhubpipetten
US20080066523A1 (en) * 2006-09-19 2008-03-20 Csem Centre Suisse D'electronique Et De Microtechnique Sa Device and method for calibrating a pipette or a dispensing system

Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US11602751B2 (en) 2017-03-31 2023-03-14 Forward Biotech, Inc. Liquid evaluation
DE102017123249A1 (de) * 2017-10-06 2019-04-11 Hamilton Bonaduz Ag Vorrichtung zur Bestimmung des Volumens einer Flüssigkeit
WO2019068724A1 (fr) * 2017-10-06 2019-04-11 Hamilton Bonaduz Ag Dispositif pour déterminer le volume d'un liquide

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