EP2968533A1 - Neuartige arzneimittel mit einer antikörperzusammensetzung, angereichert mit einer isoform mit prädominanter ladung - Google Patents
Neuartige arzneimittel mit einer antikörperzusammensetzung, angereichert mit einer isoform mit prädominanter ladungInfo
- Publication number
- EP2968533A1 EP2968533A1 EP14709977.4A EP14709977A EP2968533A1 EP 2968533 A1 EP2968533 A1 EP 2968533A1 EP 14709977 A EP14709977 A EP 14709977A EP 2968533 A1 EP2968533 A1 EP 2968533A1
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- antibody
- composition
- antibody composition
- antigen
- isoforms
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- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/2896—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against molecules with a "CD"-designation, not provided for elsewhere
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
- C07K1/14—Extraction; Separation; Purification
- C07K1/16—Extraction; Separation; Purification by chromatography
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
- C07K2317/21—Immunoglobulins specific features characterized by taxonomic origin from primates, e.g. man
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
- C07K2317/24—Immunoglobulins specific features characterized by taxonomic origin containing regions, domains or residues from different species, e.g. chimeric, humanized or veneered
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
- C07K2317/73—Inducing cell death, e.g. apoptosis, necrosis or inhibition of cell proliferation
- C07K2317/732—Antibody-dependent cellular cytotoxicity [ADCC]
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
- C07K2317/73—Inducing cell death, e.g. apoptosis, necrosis or inhibition of cell proliferation
- C07K2317/734—Complement-dependent cytotoxicity [CDC]
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- Immunology (AREA)
- General Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Microbiology (AREA)
- Epidemiology (AREA)
- Mycology (AREA)
- Biophysics (AREA)
- Molecular Biology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Genetics & Genomics (AREA)
- Biochemistry (AREA)
- Communicable Diseases (AREA)
- Oncology (AREA)
- Transplantation (AREA)
- Peptides Or Proteins (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Analytical Chemistry (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| FR1352360A FR3003171B1 (fr) | 2013-03-15 | 2013-03-15 | Nouveaux medicaments comprenant une composition d'anticorps enrichie en isoforme de charge majoritaire |
| PCT/EP2014/055179 WO2014140322A1 (fr) | 2013-03-15 | 2014-03-14 | Nouveaux médicaments comprenant une composition d'anticorps enrichie en isoforme de charge majoritaire |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| EP2968533A1 true EP2968533A1 (de) | 2016-01-20 |
Family
ID=48771615
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| EP14709977.4A Withdrawn EP2968533A1 (de) | 2013-03-15 | 2014-03-14 | Neuartige arzneimittel mit einer antikörperzusammensetzung, angereichert mit einer isoform mit prädominanter ladung |
Country Status (11)
| Country | Link |
|---|---|
| US (1) | US20160046722A1 (de) |
| EP (1) | EP2968533A1 (de) |
| JP (1) | JP2016512216A (de) |
| KR (1) | KR20150132522A (de) |
| CN (1) | CN105163758B (de) |
| AU (1) | AU2014230134A1 (de) |
| BR (1) | BR112015023209A8 (de) |
| CA (1) | CA2907358A1 (de) |
| FR (1) | FR3003171B1 (de) |
| MX (1) | MX2015012812A (de) |
| WO (1) | WO2014140322A1 (de) |
Families Citing this family (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2013004841A1 (en) | 2011-07-06 | 2013-01-10 | Genmab A/S | Modulation of complement-dependent cytotoxicity through modifications of the c-terminus of antibody heavy chains |
| JP6934016B2 (ja) | 2016-05-04 | 2021-09-08 | デラヴァル ホルディング アーベー | 乳頭カップのためのカートリッジ及び乳頭カップ |
| FR3053688A1 (fr) | 2016-07-06 | 2018-01-12 | Laboratoire Francais Du Fractionnement Et Des Biotechnologies | Mutants fc a activite fonctionnelle amelioree |
| EP3498293A1 (de) | 2017-12-15 | 2019-06-19 | Institut National De La Sante Et De La Recherche Medicale (Inserm) | Behandlung monogener erkrankungen mit einem anti-cd45rc-antikörper |
| EP3626265A1 (de) | 2018-09-21 | 2020-03-25 | INSERM (Institut National de la Santé et de la Recherche Médicale) | Anti-human-cd45rc-antikörper und verwendungen davon |
| BR112021014574A2 (pt) | 2019-01-23 | 2021-10-05 | Encefa | Competidores cd31 e usos dos mesmos |
| MX2021014336A (es) * | 2019-05-23 | 2022-03-17 | Regeneron Pharma | Caracterizacion de variantes de carga especificas del dominio de anticuerpos. |
| WO2021057726A1 (zh) * | 2019-09-23 | 2021-04-01 | 南开大学 | 利用哺乳动物展示筛选FcγR特异性结合Fc |
| WO2023041717A1 (en) | 2021-09-16 | 2023-03-23 | Aboleris Pharma | Anti-human cd45rc binding domains and uses thereof |
| CN114236010A (zh) * | 2021-12-18 | 2022-03-25 | 苏州莱奥生物技术有限公司 | 一种生物活性药物的药代动力学分析方法 |
Family Cites Families (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| ES2694002T3 (es) * | 1999-01-15 | 2018-12-17 | Genentech, Inc. | Polipéptido que comprende una región Fc de IgG1 humana variante |
| FR2807767B1 (fr) * | 2000-04-12 | 2005-01-14 | Lab Francais Du Fractionnement | Anticorps monoclonaux anti-d |
| FR2844513B1 (fr) * | 2002-09-13 | 2007-08-03 | Lab Francais Du Fractionnement | Anticorps pour adcc et induisant la production de cytokines. |
| DK2345671T3 (en) * | 2002-09-27 | 2016-02-15 | Xencor Inc | Optimized Fc variants and methods for their formation |
| EP2330130B1 (de) * | 2002-10-17 | 2014-08-27 | Genmab A/S | Humane monoklonale Antikörper gegen CD20 |
| JP2006524039A (ja) * | 2003-01-09 | 2006-10-26 | マクロジェニクス，インコーポレーテッド | 変異型Ｆｃ領域を含む抗体の同定および作製ならびにその利用法 |
| FR2861078B1 (fr) * | 2003-10-16 | 2007-09-21 | Lab Francais Du Fractionnement | NOUVELLES IgG3 UTILES POUR STIMULER LA PHAGOCYTOSE |
| SG10201912554TA (en) * | 2005-03-23 | 2020-02-27 | Genmab As | Antibodies against cd38 for treatment of multiple myeloma |
| WO2013004841A1 (en) * | 2011-07-06 | 2013-01-10 | Genmab A/S | Modulation of complement-dependent cytotoxicity through modifications of the c-terminus of antibody heavy chains |
-
2013
- 2013-03-15 FR FR1352360A patent/FR3003171B1/fr not_active Expired - Fee Related
-
2014
- 2014-03-14 CN CN201480024699.3A patent/CN105163758B/zh not_active Expired - Fee Related
- 2014-03-14 BR BR112015023209A patent/BR112015023209A8/pt not_active Application Discontinuation
- 2014-03-14 CA CA2907358A patent/CA2907358A1/fr not_active Abandoned
- 2014-03-14 WO PCT/EP2014/055179 patent/WO2014140322A1/fr active Application Filing
- 2014-03-14 EP EP14709977.4A patent/EP2968533A1/de not_active Withdrawn
- 2014-03-14 JP JP2015562236A patent/JP2016512216A/ja active Pending
- 2014-03-14 MX MX2015012812A patent/MX2015012812A/es unknown
- 2014-03-14 US US14/776,725 patent/US20160046722A1/en not_active Abandoned
- 2014-03-14 AU AU2014230134A patent/AU2014230134A1/en not_active Abandoned
- 2014-03-14 KR KR1020157029822A patent/KR20150132522A/ko not_active Application Discontinuation
Non-Patent Citations (7)
| Title |
|---|
| BEATE HINTERSTEINER ET AL: "Charge heterogeneity: Basic antibody charge variants with increased binding to Fc receptors", MABS, vol. 8, no. 8, 25 August 2016 (2016-08-25), US, pages 1548 - 1560, XP055429321, ISSN: 1942-0862, DOI: 10.1080/19420862.2016.1225642 * |
| KANDA YUTAKA ET AL: "Comparison of cell lines for stable production of fucose-negative antibodies with enhanced ADCC", BIOTECHNOLOGY AND BIOENGINEERING, WILEY ETC, vol. 94, no. 4, 1 July 2006 (2006-07-01), pages 680 - 688, XP002415543, ISSN: 0006-3592, DOI: 10.1002/BIT.20880 * |
| LESLIE A. KHAWLI ET AL: "Charge variants in IgG1: Isolation, characterization, in vitro binding properties and pharmacokinetics in rats", MABS, vol. 2, no. 6, 1 November 2010 (2010-11-01), pages 613 - 624, XP055090287, ISSN: 1942-0862, DOI: 10.4161/mabs.2.6.13333 * |
| MASUDA ET AL: "Enhanced binding affinity for FcgammaRIIIa of fucose-negative antibody is sufficient to induce maximal antibody-dependent cellular cytotoxicity", MOLECULAR IMMUNOLOGY, PERGAMON, GB, vol. 44, no. 12, 17 April 2007 (2007-04-17), pages 3122 - 3131, XP022031617, ISSN: 0161-5890, DOI: 10.1016/J.MOLIMM.2007.02.005 * |
| ROZHKOVA ET AL: "Quantitative analysis of monoclonal antibodies by cation-exchange chromatofocusing", JOURNAL OF CHROMATOGRAPHY A, ELSEVIER, AMSTERDAM, NL, vol. 1216, no. 32, 7 August 2009 (2009-08-07), pages 5989 - 5994, XP026305768, ISSN: 0021-9673, [retrieved on 20090618], DOI: 10.1016/J.CHROMA.2009.06.045 * |
| SCALLON ET AL: "Higher levels of sialylated Fc glycans in immunoglobulin G molecules can adversely impact functionality", MOLECULAR IMMUNOL, PERGAMON, GB, vol. 44, no. 7, 26 November 2006 (2006-11-26), pages 1524 - 1534, XP005792683, ISSN: 0161-5890, DOI: 10.1016/J.MOLIMM.2006.09.005 * |
| See also references of WO2014140322A1 * |
Also Published As
| Publication number | Publication date |
|---|---|
| BR112015023209A8 (pt) | 2018-01-23 |
| AU2014230134A1 (en) | 2015-10-29 |
| CA2907358A1 (fr) | 2014-09-18 |
| CN105163758B (zh) | 2017-11-17 |
| KR20150132522A (ko) | 2015-11-25 |
| FR3003171A1 (fr) | 2014-09-19 |
| JP2016512216A (ja) | 2016-04-25 |
| MX2015012812A (es) | 2016-05-09 |
| FR3003171B1 (fr) | 2015-04-10 |
| CN105163758A (zh) | 2015-12-16 |
| WO2014140322A1 (fr) | 2014-09-18 |
| US20160046722A1 (en) | 2016-02-18 |
| BR112015023209A2 (pt) | 2017-07-18 |
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