MX2015012812A - Medicamentos novedosos que comprenden una composicion de anticuerpo enriquecida con isoforma de carga mayor. - Google Patents

Medicamentos novedosos que comprenden una composicion de anticuerpo enriquecida con isoforma de carga mayor.

Info

Publication number
MX2015012812A
MX2015012812A MX2015012812A MX2015012812A MX2015012812A MX 2015012812 A MX2015012812 A MX 2015012812A MX 2015012812 A MX2015012812 A MX 2015012812A MX 2015012812 A MX2015012812 A MX 2015012812A MX 2015012812 A MX2015012812 A MX 2015012812A
Authority
MX
Mexico
Prior art keywords
antibody composition
composition enriched
predominant
antibody
novel medicaments
Prior art date
Application number
MX2015012812A
Other languages
English (en)
Inventor
Guillaume Chevreux
Nicolas Bihoreau
Original Assignee
Lab Francais Du Fractionnement
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Lab Francais Du Fractionnement filed Critical Lab Francais Du Fractionnement
Publication of MX2015012812A publication Critical patent/MX2015012812A/es

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • A61K39/39591—Stabilisation, fragmentation
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2896—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against molecules with a "CD"-designation, not provided for elsewhere
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
    • C07K1/14—Extraction; Separation; Purification
    • C07K1/16—Extraction; Separation; Purification by chromatography
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
    • C07K2317/21—Immunoglobulins specific features characterized by taxonomic origin from primates, e.g. man
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
    • C07K2317/24—Immunoglobulins specific features characterized by taxonomic origin containing regions, domains or residues from different species, e.g. chimeric, humanized or veneered
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/73—Inducing cell death, e.g. apoptosis, necrosis or inhibition of cell proliferation
    • C07K2317/732—Antibody-dependent cellular cytotoxicity [ADCC]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/73—Inducing cell death, e.g. apoptosis, necrosis or inhibition of cell proliferation
    • C07K2317/734—Complement-dependent cytotoxicity [CDC]

Abstract

La presente invención está en el campo técnico de terapias de anticuerpo que comprende un mecanismo de destrucción de células diana mediante ADCC. Se refiere a composiciones purificadas de anticuerpos, obtenidas mediante fraccionamiento cromatográfico de las varias isoformas de carga naturalmente presentes en una composición de anticuerpo y por combinación de una o más fracciones cromatográficas que corresponden al pico pre-dominante del cromatograma, la composición resultante de anticuerpos monoclonales que se enriquece en el pico dominante, el pico que representa al menos 85% del cromatograma de la composición obtenida, para el uso como un medicamento.
MX2015012812A 2013-03-15 2014-03-14 Medicamentos novedosos que comprenden una composicion de anticuerpo enriquecida con isoforma de carga mayor. MX2015012812A (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
FR1352360A FR3003171B1 (fr) 2013-03-15 2013-03-15 Nouveaux medicaments comprenant une composition d'anticorps enrichie en isoforme de charge majoritaire
PCT/EP2014/055179 WO2014140322A1 (fr) 2013-03-15 2014-03-14 Nouveaux médicaments comprenant une composition d'anticorps enrichie en isoforme de charge majoritaire

Publications (1)

Publication Number Publication Date
MX2015012812A true MX2015012812A (es) 2016-05-09

Family

ID=48771615

Family Applications (1)

Application Number Title Priority Date Filing Date
MX2015012812A MX2015012812A (es) 2013-03-15 2014-03-14 Medicamentos novedosos que comprenden una composicion de anticuerpo enriquecida con isoforma de carga mayor.

Country Status (11)

Country Link
US (1) US20160046722A1 (es)
EP (1) EP2968533A1 (es)
JP (1) JP2016512216A (es)
KR (1) KR20150132522A (es)
CN (1) CN105163758B (es)
AU (1) AU2014230134A1 (es)
BR (1) BR112015023209A8 (es)
CA (1) CA2907358A1 (es)
FR (1) FR3003171B1 (es)
MX (1) MX2015012812A (es)
WO (1) WO2014140322A1 (es)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US10323081B2 (en) * 2011-07-06 2019-06-18 Genmag A/S Modulation of complement-dependent cytotoxicity through modifications of the C-terminus of antibody heavy chains
WO2017192093A1 (en) 2016-05-04 2017-11-09 Delaval Holding Ab A cartridge for a teatcup, and a teatcup
FR3053688A1 (fr) 2016-07-06 2018-01-12 Laboratoire Francais Du Fractionnement Et Des Biotechnologies Mutants fc a activite fonctionnelle amelioree
EP3498293A1 (en) 2017-12-15 2019-06-19 Institut National De La Sante Et De La Recherche Medicale (Inserm) Treatment of monogenic diseases with an anti-cd45rc antibody
EP3626265A1 (en) 2018-09-21 2020-03-25 INSERM (Institut National de la Santé et de la Recherche Médicale) Anti-human cd45rc antibodies and uses thereof
AU2020211728A1 (en) 2019-01-23 2021-08-12 Encefa CD31 competitors and uses thereof
CN113874720A (zh) * 2019-05-23 2021-12-31 瑞泽恩制药公司 抗体结构域特异性电荷变异体的表征分析
CN114829407A (zh) * 2019-09-23 2022-07-29 南开大学 利用哺乳动物展示筛选FcγR特异性结合Fc
WO2023041717A1 (en) 2021-09-16 2023-03-23 Aboleris Pharma Anti-human cd45rc binding domains and uses thereof
CN114236010A (zh) * 2021-12-18 2022-03-25 苏州莱奥生物技术有限公司 一种生物活性药物的药代动力学分析方法

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
HUP0104865A3 (en) * 1999-01-15 2004-07-28 Genentech Inc Polypeptide variants with altered effector function
FR2807767B1 (fr) * 2000-04-12 2005-01-14 Lab Francais Du Fractionnement Anticorps monoclonaux anti-d
FR2844513B1 (fr) * 2002-09-13 2007-08-03 Lab Francais Du Fractionnement Anticorps pour adcc et induisant la production de cytokines.
BRPI0314814C1 (pt) * 2002-09-27 2021-07-27 Xencor Inc anticorpo compreendendo uma variante de fc
SI1558648T1 (sl) * 2002-10-17 2012-05-31 Genmab As Človeška monoklonalna protitelesa proti CD
EP2368578A1 (en) * 2003-01-09 2011-09-28 Macrogenics, Inc. Identification and engineering of antibodies with variant Fc regions and methods of using same
FR2861078B1 (fr) * 2003-10-16 2007-09-21 Lab Francais Du Fractionnement NOUVELLES IgG3 UTILES POUR STIMULER LA PHAGOCYTOSE
SG10201912554TA (en) * 2005-03-23 2020-02-27 Genmab As Antibodies against cd38 for treatment of multiple myeloma
US10323081B2 (en) * 2011-07-06 2019-06-18 Genmag A/S Modulation of complement-dependent cytotoxicity through modifications of the C-terminus of antibody heavy chains

Also Published As

Publication number Publication date
CA2907358A1 (fr) 2014-09-18
BR112015023209A8 (pt) 2018-01-23
JP2016512216A (ja) 2016-04-25
CN105163758A (zh) 2015-12-16
EP2968533A1 (fr) 2016-01-20
KR20150132522A (ko) 2015-11-25
AU2014230134A1 (en) 2015-10-29
BR112015023209A2 (pt) 2017-07-18
US20160046722A1 (en) 2016-02-18
CN105163758B (zh) 2017-11-17
FR3003171A1 (fr) 2014-09-19
FR3003171B1 (fr) 2015-04-10
WO2014140322A1 (fr) 2014-09-18

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