Classifications

• • C—CHEMISTRY; METALLURGY
  • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
  • C08J—WORKING-UP; GENERAL PROCESSES OF COMPOUNDING; AFTER-TREATMENT NOT COVERED BY SUBCLASSES C08B, C08C, C08F, C08G or C08H
  • C08J9/00—Working-up of macromolecular substances to porous or cellular articles or materials; After-treatment thereof
  • C08J9/0061—Working-up of macromolecular substances to porous or cellular articles or materials; After-treatment thereof characterized by the use of several polymeric components
• • C—CHEMISTRY; METALLURGY
  • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
  • C08G—MACROMOLECULAR COMPOUNDS OBTAINED OTHERWISE THAN BY REACTIONS ONLY INVOLVING UNSATURATED CARBON-TO-CARBON BONDS
  • C08G18/00—Polymeric products of isocyanates or isothiocyanates
  • C08G18/06—Polymeric products of isocyanates or isothiocyanates with compounds having active hydrogen
  • C08G18/08—Processes
  • C08G18/14—Manufacture of cellular products
• • A—HUMAN NECESSITIES
  • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
  • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
  • A61F13/00—Bandages or dressings; Absorbent pads
  • A61F13/15—Absorbent pads, e.g. sanitary towels, swabs or tampons for external or internal application to the body; Supporting or fastening means therefor; Tampon applicators
  • A61F13/53—Absorbent pads, e.g. sanitary towels, swabs or tampons for external or internal application to the body; Supporting or fastening means therefor; Tampon applicators characterised by the absorbing medium
• • A—HUMAN NECESSITIES
  • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
  • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
  • A61L15/00—Chemical aspects of, or use of materials for, bandages, dressings or absorbent pads
  • A61L15/16—Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons
  • A61L15/42—Use of materials characterised by their function or physical properties
  • A61L15/425—Porous materials, e.g. foams or sponges
• • A—HUMAN NECESSITIES
  • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
  • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
  • A61L15/00—Chemical aspects of, or use of materials for, bandages, dressings or absorbent pads
  • A61L15/16—Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons
  • A61L15/42—Use of materials characterised by their function or physical properties
  • A61L15/60—Liquid-swellable gel-forming materials, e.g. super-absorbents
• • A—HUMAN NECESSITIES
  • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
  • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
  • A61P17/00—Drugs for dermatological disorders
  • A61P17/02—Drugs for dermatological disorders for treating wounds, ulcers, burns, scars, keloids, or the like
• • C—CHEMISTRY; METALLURGY
  • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
  • C08G—MACROMOLECULAR COMPOUNDS OBTAINED OTHERWISE THAN BY REACTIONS ONLY INVOLVING UNSATURATED CARBON-TO-CARBON BONDS
  • C08G18/00—Polymeric products of isocyanates or isothiocyanates
  • C08G18/06—Polymeric products of isocyanates or isothiocyanates with compounds having active hydrogen
• • C—CHEMISTRY; METALLURGY
  • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
  • C08L—COMPOSITIONS OF MACROMOLECULAR COMPOUNDS
  • C08L3/00—Compositions of starch, amylose or amylopectin or of their derivatives or degradation products
  • C08L3/02—Starch; Degradation products thereof, e.g. dextrin
• • C—CHEMISTRY; METALLURGY
  • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
  • C08L—COMPOSITIONS OF MACROMOLECULAR COMPOUNDS
  • C08L75/00—Compositions of polyureas or polyurethanes; Compositions of derivatives of such polymers
  • C08L75/04—Polyurethanes
• • C—CHEMISTRY; METALLURGY
  • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
  • C08G—MACROMOLECULAR COMPOUNDS OBTAINED OTHERWISE THAN BY REACTIONS ONLY INVOLVING UNSATURATED CARBON-TO-CARBON BONDS
  • C08G2101/00—Manufacture of cellular products

Definitions

• a novel hydrophilic polymeric foam comprising maltodextrin
• the present invention relates to a novel hydrophilic polymeric foam comprising maltodextrin whose rate of absorption of a liquid is improved over a conventional hydrophilic polymeric foam.
• the present invention finds application in the fields of hygiene and health, in particular in devices for which efficient absorption of biological fluids is required.
• the present invention finds particular application in the field of dressings, personal hygiene products, hygienic devices such as diapers, sanitary napkins, pads, or wipes.
• the invention is also applicable in the fields of cosmetics and horticulture.
• the mechability or wicking effect of a foam is generally defined as the duration put by a precise amount of liquid to be absorbed on the surface of the foam and spread in its volume.
• This intrinsic characteristic of the hydrophilic polymer foam is particularly decisive in the medical field, for example for the management of oozing wounds releasing exudates, but also in the fields of hygienic products and horticulture where the management of fluids is an important problem.
• hygienic devices capable of absorbing biological fluids, but also able to move them away from the surface of the skin.
• the skin of people, thus preserved from any moisture, is no longer subject to irritation or redness, for example in the case of exposure to a diaper stained urinary secretions.
• Hydrophilic polyurethane foams are generally prepared by polymerization of a hydrophilic prepolymer possessing isocyanate end groups which are activated in the presence of water.
• US 4,740,528 discloses a composition for the manufacture of a hydrophilic polyurethane foam containing amino acids whose properties of incompetency are improved.
• the foam is obtained from an isocyanate-terminated poly (alkyleneoxy) polyol prepolymer, in aqueous solution, the pH of which does not exceed 8.
• the prepolymer is associated with at least one amino acid having a carboxylic acid group.
• the carboxylic acid groups of the amino acid provide the foam with improved hydrophilic properties.
• the mechhability of polymeric foams has been improved by choosing a simpler alternative to produce, the manufacture of the foam that is the subject of the present invention being free of any pH constraint.
• the present invention therefore consists of a new hydrophilic polymer foam, in particular a hydrophilic polyurethane foam, comprising maltodextrin.
• WO 2007/095713 describes a biodegradable hydrophobic polyurethane foam obtained by mixing polyhydroxybutyrates, polyols, isocyanates. It is suggested in this document to use maltodextrin as a polyol. Maltodextrin, used as a reaction intermediate along with isocyanates, reacts chemically with isocyanates to form polyurethane molecules. Maltodextrin is therefore not found in the foam in native form. In addition, the hydrophobicity of such a foam does not allow it to respond to the prerogatives of mismanagement.
• the application WO 2008/157711 of the company Rynel describes, in a particular embodiment, a nonwoven on which capsules of active principles have been deposited.
• the capsules are fixed to the nonwoven by casting on a hyphophilic or hydrophobic polyurethane foam, which allows to preserve and protect them.
• a hyphophilic or hydrophobic polyurethane foam which allows to preserve and protect them.
• Maltodextrin is also known to absorb good amounts of oil. It is generally used as blowing agent, encapsulant, filler, excipient or aroma carrier. It is also known to be a sorbent agent in the intestine and allow a better assimilation of various nutrients at this level, in which it is very popular with athletes.
• hydrophilic polymer foam characterized in that it comprises maltodextrin.
• hydrophilic polymer foam is understood to mean a cellular material, obtained by a polymerization reaction, having absorption properties of aqueous liquids.
• the polymeric foam may be selected from hydrophilic polyurethane foams and polyvinyl alcohol (PVA) foams.
• the invention consists of a hydrophilic polyurethane foam comprising a quantity of maltodextrin of between 1 and 50% by weight, preferably between 3 and 20% by weight, and more preferably between 3 and 10% by weight. % by weight, of the final weight of said foam.
• the subject of the invention is the use of maltodextrin as a disintegrating agent in a hydrophilic polymer foam, especially when this foam is included in a dressing of the hydrocellular or hydrocolloid type.
• the invention relates to a method for preparing a hydrophilic polymer foam which comprises preparing a reaction mixture comprising monomers or a prepolymer intended to polymerize, and to bring said mixture into contact with maltodextrin. .
• the present invention consists of a new hydrophilic polymer foam characterized in that it comprises maltodextrin.
• the hydrophilic polymeric foam may be selected from hydrophilic polyurethane foams or polyvinyl alcohol (PVA) foams.
• the foam is a hydrophilic polyurethane foam.
• a hydrophilic polyurethane foam can be made from a precursor mixture in the form of an aqueous dispersion containing either monomers or prepolymers.
• the prepolymer of the hydrophilic polyurethane foam can already be synthesized. On the contrary, if the prepolymer is to be prepared, it is possible to make the hydrophilic polyurethane foam in one or two steps. In one step, the hydrophilic polyurethane foam is made by reacting both polyols, polyisocyanates, water and a surfactant. In two steps, the prepolymer is synthesized in a step prior to the addition of water and surfactant, by reacting the polyols and polyisocyanates.
• the prepolymer is already synthesized, it suffices simply to react the latter with water and a surfactant to obtain a hydrophilic polyurethane foam.
• the surfactant is not an essential compound for the production of a hydrophilic polyurethane foam, it is only optional, but plays a major role on the control of the reaction and on the physico-chemical characteristics foam obtained.
• polyol means any natural or synthetic compound having a plurality of hydroxyl groups, said groups being capable of reacting with isocyanate groups to yield urethane bridges.
• polyethylene glycol and polyethers are the most frequently used by manufacturers of hydrophilic polyurethane foams, in particular because of their hydrophilicity.
• polyols of natural origin these can be derived from the products defined by the following non-exhaustive list: xylose, arabinose, glucose, sucrose, dextrins, glycerin, starch, castor oil, soybean oil, vegetable oil.
• the polyols preferably used will be of the poly (ethyleneoxy) polyol or poly (propyleneoxy) polyols type or a mixture of both.
• polyisocyanates any compound which may be selected from the group consisting of toluene-2,4-diisocyanate, toluene-2,6-diisocyanate, ethylidene diisocyanate, propylene-1,2-diisocyanate, cyclohexylene-1, 2-diisocyanate, cyclohexylene-1, 4-diisocyanate, triphenylmethane 4, 4 1, 4 "triisocyanate, diisocyanate, m-phenylene, 4, 4'-biphenylene diisocyanate, 3, 3 '4'-dichloro-4'-biphenylene diisocyanate, benzene-1,3,5-triisocyanate, toluene-2,4,6-triisocyanate, 2,4,4-diphenyl-2,4,4-triisocyanate, 1,4-tetramethylene diisocyanate, 1, ⁇ -hex
• the constituent prepolymers of a hydrophilic polyurethane foam are preferably of the poly (alkyleneoxy) polyol type. These prepolymers, polyurethane prepolymers having isocyanate terminal bonds are particularly preferred such as prepolymers marketed under the trademark Dow Hypol ®, ® PREPOL by Lendell Manufacturing Inc. ® Hydropol by Mace Adhesives & Coatings Co., Aquapol ® by Carpenter Co. and Urepol ® by EnviroChem Technologies.
• isocyanate terminal bonds may correspond to aromatic isocyanates, for example toluene diisocyanate (TDI) or methylene diphenyl isocyanate (MDI), or to aliphatic isocyanate groups, for example isophorone diisocyanate (IPDI), but also hydrogenated methylene diphenyl isocyanate (HMDI).
• aromatic isocyanates for example toluene diisocyanate (TDI) or methylene diphenyl isocyanate (MDI)
• IPDI isophorone diisocyanate
• HMDI hydrogenated methylene diphenyl isocyanate
• the precursor mixture of the foam may contain a surfactant of cationic, anionic or nonionic type or a silicone-based surfactant.
• surfactants known in the state of the art can be proposed for its incorporation into the production of a hydrophilic polyurethane foam.
• known surfactants cationic surfactants, nonionic surfactants or anionic surfactants such as fatty acid salts, sulfuric acid ester salts, phosphoric acid ester salts and sulfonates may be present in the basic composition object of the present invention.
• the surfactants used in the production of a hydrophilic polyurethane foam will be nonionic surfactants such as certain products marketed by BASF under the name Pluronic ® .
• the surfactant used in the production of a hydrophilic polyurethane foam is Pluronic PE6200 ®, oxide copolymer of ethylene oxide and propylene oxide, or Pluronic PE6800 ®.
• Another type of known surfactant that can be used in the context of the present invention is represented by silicone-based surfactants.
• hydrolyzable copolymers of polysiloxane-polyoxyalkylene there may be mentioned hydrolyzable copolymers of polysiloxane-polyoxyalkylene, non-hydrolyzable copolymers of polysiloxane-polyoxyalkylene, cyanoalkylpolysiloxanes, alkylpolysiloxanes, polydimethylsiloxanes and dimethylpolysiloxanes-polyoxyalkylene modified.
• the type of silicone-based surfactant used and the amount required depend on the type of foam to be produced.
• the maltodextrin used in the context of the present invention is a product of the hydrolysis of starch. Once mixed with the precursor monomers or prepolymers of the hydrophilic polymer foam, the maltodextrin advantageously retains its native form: it does not react chemically with the constituents of the foam and is found to be disseminated throughout the foam thus produced. Maltodextrin is preferably distributed throughout the mass of the foam.
• Maltodextrin preferably has an equivalent dextrose (DE) less than or equal to 20. It is in the form of an odorless powder and neutral taste that can be represented by the following formula:
• Maltodextrin with very good dispersion and water solubility.
• Maltodextrin thus preferably has a particle size of between 40 and 500 ⁇ .
• the maltodextrin introduced into the foam of the present invention is for example of the brand Glucidex ® produced by Roquette.
• the maltodextrin is preferably between 1 and 50% by weight, preferably between 3 and 20%, for example between 3 and 10%, by weight of the total weight of the foam.
• the invention also relates to a method for preparing a hydrophilic polymer foam which comprises preparing a reaction mixture comprising monomers or a prepolymer for polymerizing, and to bring said mixture with maltodextrin.
• the maltodextrin may be incorporated into the hydrophilic polyurethane foam either in the form of a powder during a step prior to the synthesis of said foam, or mixed in the aqueous phase, that is to say introduced into a solution of surfactant and distilled water.
• the hydrophilic polymer foam of the invention is obtained incorporating the maltodextrin (in solid form or solution form) into a solution of monomers or prepolymer, so that the polymerization reaction occurs in the presence of maltodextrin.
• maltodextrin in solid form or solution form
• a hydrophilic polyurethane foam whose properties of dishability are improved, simply mix in a container, a large amount of distilled water and surfactant, then homogenize said preparation.
• a pre-established amount of this preparation is taken and maltodextrin is added thereto.
• the mixture is mixed with a mixer, then in a third step is added prepolymer.
• the preparation thus obtained is again mixed in a mixer, then allowed to swell or poured between two siliconized papers and put in an oven for a prolonged period.
• hydrophilic polyurethane foam by depositing in a first step maltodextrin powder in the bottom of the container before casting a reaction mixture based on surfactant, water and prepolymer.
• hydrophilic polyurethane foams are produced according to two types of process, a method for obtaining such a foam in the so-called “mattress” form, foam which in a second time will be cut out at a desired thickness value, and a controlled thickness process in which the foam is obtained directly at a desired thickness value.
• foams in the so-called “mushroom” form are produced to reproduce the process of obtaining foam in the form of a mattress, and foams in the form of a plate are produced to reproduce on a small scale. scale a process for obtaining controlled thickness foam.
• foam in the form of a plate it suffices to pour the foam obtained at the end of the third step described above between two silicone papers separated on each side by shims whose thickness corresponds to the desired thickness. foam and on which, on its upper surface, is affixed a plate and a weight to limit the vertical rise of said foam. If it is desired to obtain a foam in the form of a mushroom, it suffices simply to allow the foam to swell in a container during the final stage and allow it to rise, without, of course, spreading it out.
• the mismanagement of the hydrophilic polymeric foam can be evaluated according to the following test, preferably when it is obtained by a "mattress" type process.
• the foam is cut into several slices, and the wicking test is performed on each slice, to control that the absorption rate is the same on all levels of the foam.
• a solution based on distilled water and dye is prepared, a solution of which a predetermined volume is poured onto the surface of the chosen slice of foam. The time taken for this solution to be totally absorbed is calculated. This gives the absorption time of a given volume. This makes it possible to determine the speed put by a drop of volume x to be absorbed, and thus to define the value given to the mechability or wicking effect of the foam.
• the object of the present invention finds a preferred application in the provision of dressings for the absorption of wound exudates.
• Maltodextrin incorporated into a hydrophilic polyurethane foam indeed promotes the absorption of exudates from the wound of the patient.
• the foam is the main layer of the dressing or one of the layers of the latter.
• the hydrophilic polymer foam comprising maltodextrin may be used in the manufacture of hydrocellular or hydrocolloid type dressings.
• the invention thus has for another object a hydrocellular or hydrocolloid dressing comprising a hydrophilic polymer foam comprising maltodextrin as described above.
• the invention also relates to the use of maltodextrin as a disintegrating agent in a hydrophilic polymer foam, in particular when the foam is part of a dressing of the hydrocellular or hydrocolloid type.
• maltodextrin may also be used as an agent for promoting the absorption of exudates from a wound to which the dressing is applied.
• the foam of the invention can be used more generally for any application that requires the absorption of liquids such as water or various urinary secretions. This may be particularly useful in horticulture where water absorption and retention allow decreased irrigation intervals or better rooting of the plant, but also in different hygiene devices, such as nappy pants, where the absorption of liquid by the foam is its distance from the surface makes it possible not to maintain contact such a wet device to the skin, and thus prevent the appearance of many lesions. Examples
• the Glucidex IT 12 ® in the form of powder can be deposited beforehand at the bottom of the beaker, beaker in which will be poured the reaction mixture constituting the foam in a second time. It is therefore necessary to deposit 1 g of Glucidex IT 12 ® in the bottom of a beaker. Then the constitutive mixture of the polyurethane foam is poured onto this powder so as to obtain a foam comprising maltodextrin in the form of mushroom, that is to say that the foam is not spread, the latter swells and therefore takes height.
• a foam in the form of a plate It is also possible to make a foam in the form of a plate.
• the foam is cast between two silicone papers separated on each side by shims of the thickness that is desired to give to the foam, for example 4 mm and on which is found affixed to its surface upper plate and a weight to limit the vertical rise of said foam. After expansion, this set is put in an oven at 70 ° C for at least 4 hours.
• the measured mechability is 20 seconds on all the slices, even the upper slice of the fungus.
• Glucidex IT 12 ® diffuses over the entire height of the mushroom.
• the cutting step applied to the foam obtained in the form of a mushroom is abstained.
• the measurement test of the wicking effect of a liquid will be performed directly on each of the two faces of the foam obtained in the form of a plate. The goal is to see if this wick effect is identical on each side of the foam .
• the measured mechability is between 45 seconds and 1 minute 20 seconds on the face of the foam that has been in contact with the Glucidex IT 12 ® .
• the results obtained in the context of the present invention are indeed significant because the Maltodextrin increases the absorption kinetics of a hydrophilic polyurethane foam. Indeed, the absorption rates of the colored water drop of a volume of 200 ⁇ deposited on the surface of a hydrophilic polyurethane foam comprising maltodextrin are between 45 and 80 seconds.
• the negative control, hydrophilic polyurethane foam not comprising maltodextrin has meanwhile absorption kinetics greater than 2 minutes.
• these results corroborate the fact that maltodextrin has a role of disintegrating agent in a hydrophilic polymer foam.

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• Health & Medical Sciences (AREA)
• Chemical & Material Sciences (AREA)
• Engineering & Computer Science (AREA)
• Medicinal Chemistry (AREA)
• Organic Chemistry (AREA)
• Chemical Kinetics & Catalysis (AREA)
• Public Health (AREA)
• Animal Behavior & Ethology (AREA)
• Veterinary Medicine (AREA)
• General Health & Medical Sciences (AREA)
• Life Sciences & Earth Sciences (AREA)
• Polymers & Plastics (AREA)
• Epidemiology (AREA)
• Materials Engineering (AREA)
• Dispersion Chemistry (AREA)
• Hematology (AREA)
• Biomedical Technology (AREA)
• Heart & Thoracic Surgery (AREA)
• Vascular Medicine (AREA)
• Manufacturing & Machinery (AREA)
• Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
• Pharmacology & Pharmacy (AREA)
• Dermatology (AREA)
• General Chemical & Material Sciences (AREA)
• Bioinformatics & Cheminformatics (AREA)
• Polyurethanes Or Polyureas (AREA)
• Absorbent Articles And Supports Therefor (AREA)
• Polysaccharides And Polysaccharide Derivatives (AREA)
• Manufacture Of Porous Articles, And Recovery And Treatment Of Waste Products (AREA)
• Medicinal Preparation (AREA)
• Materials For Medical Uses (AREA)

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• 2012
  • 2012-12-18 FR FR1262193A patent/FR2999580A1/fr not_active Withdrawn
• 2013
  • 2013-12-16 BR BR112015014612-0A patent/BR112015014612A2/pt not_active IP Right Cessation
  • 2013-12-16 EP EP13818305.8A patent/EP2935425A1/de not_active Withdrawn
  • 2013-12-16 JP JP2015548708A patent/JP2016504454A/ja active Pending
  • 2013-12-16 WO PCT/FR2013/053091 patent/WO2014096654A1/fr active Application Filing
  • 2013-12-16 CN CN201380066124.3A patent/CN104870535A/zh active Pending
  • 2013-12-16 CA CA2893998A patent/CA2893998A1/fr not_active Abandoned
  • 2013-12-16 US US14/653,209 patent/US20150329665A1/en not_active Abandoned

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