CN115124752A - 一种复合水凝胶敷料及其制备方法 - Google Patents
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Abstract
本发明属于生物医用材料领域,公开了一种复合水凝胶敷料及其制备方法,该复合水凝胶敷料由麦芽糊精和聚乙烯醇在酸性体系下物理交联制得。该制备方法简单稳定,且无需添加引发剂、交联剂和稳定剂,也不存在未反应的单体。所制备的复合水凝胶材料具有良好的孔隙结构和机械强度,同时不含有毒或刺激物,安全性更高,且具有透气性好、保水性好,防止微生物入侵等优点,能够为创面提供湿润、干净的微环境,并且吸收多余的组织分泌物,从而为伤口提供保护。麦芽糊精和聚乙烯醇作为主要原料,在生物体内可降解,具有良好的抗菌性,具有良好的生物相容性,可促进胶原形成、肉芽组织生长和上皮细胞增殖。
Description
技术领域
本发明属于生物医用材料领域,具体涉及一种复合水凝胶敷料及其制备方法。
背景技术
当组织因机械、物理或代谢相关问题而被破坏或细胞完整性受损时,就会发生创伤。伤口愈合是指受损的皮肤组织经过炎症反应、组织再生和重塑的病理生理过程,是一个极其复杂的机制,包括创面渗出液引发的炎症反应、成纤维细胞的增生和表皮细胞的迁移、肉芽组织的积累和伤口的收缩、瘢痕的形成及组织改建。敷料作为暂时性皮肤替代物可起到保护创面、止血、防止感染等作用,同时具有固定作用。随着对创面愈合的不断深入研究,人们认识到创面敷料不仅应具有覆盖创面的作用,更重要的是具有促进创面愈合的功能。
传统的创面敷料(天然或合成的绑带、药棉、纱布等)仍是目前应用最广的敷料,其促愈合机制主要是通过吸收伤口分泌物并使其中的水分蒸发,从而保持伤口干燥并防止有害细菌进入伤口引起感染。其缺点是容易造成异物反应,易滋生细菌,创面渗出液易与干燥真皮组织粘连后形成痂皮,妨碍上皮化进程;创面与纱布粘连后,换药揭起时极易引起剧烈疼痛,甚至带来二次创伤。随着皮肤伤口修复理论及组织工程学的研究和发展,创面敷料已经从传统敷料发展到了新型敷料,其中水凝胶是一类以水为分散介质在化学键、氢键、范德华力或物理缠结的作用下交联形成的三维网络结构,可以维持一个湿润的伤口愈合环境,在发生交联反应时能将大量的水分子锁住形成一种半固态物质,具有丰富的孔隙和良好的亲水性;有助于气体交换的同时,还能保持伤口处的液体平衡。更重要的是,疏松多孔的结构还可以模拟细胞外基质(ECM)的结构和功能,促进细胞迁移、增殖和成熟。这些特性使得水凝胶具有优异的亲水性和生物相容性,因此能够广泛应用于生物医药、伤口敷料和卫生用品等领域。
但是,现有的水凝胶在制备过程中,大多数会加入引发剂、交联剂、稳定剂以及未反应的单体等,如果渗入生物组织,它们可能会毒害宿主细胞,会限制水凝胶在伤口敷料中的应用。
发明内容
本发明的目的是解决现有技术的不足,提供一种复合水凝胶敷料及其制备方法,具体采用以下的技术方案:
一种复合水凝胶敷料的制备方法,包括以下步骤:
将单宁酸分散于水中,得到溶液A;随后加入麦芽糊精,于63℃-67℃下搅拌,使其完全溶解,得到溶液B;随后将溶液C加入至溶液B中,于93℃-97℃下搅拌均匀,得到溶液D;然后进行冷冻-解冻循环过程,次数为3-5次;得到麦芽糊精-聚乙烯醇复合水凝胶敷料;
溶液C的得到过程为:将聚乙烯醇加入水中,于93℃-97℃下搅拌,使其完全溶解,冷却至室温后进行脱泡处理,得到溶液C。
本发明提供了一种在酸性体系下麦芽糊精-聚乙烯醇复合水凝胶材料的制备方法,制备方法简单,工艺流程稳定,且无需添加引发剂、交联剂和稳定剂,也不存在未反应的单体。所制备的复合水凝胶材料具有良好的孔隙结构和机械强度,同时不含有毒或刺激物,安全性更高,且具有透气性好、保水性好,防止微生物入侵等优点,能够为创面提供湿润、干净的微环境,并且吸收多余的组织分泌物,从而为伤口提供保护。麦芽糊精和聚乙烯醇作为主要原料,在生物体内可降解,具有良好的抗菌性,具有良好的生物相容性,可促进胶原形成、肉芽组织生长和上皮细胞增殖。
优选地,在上述制备方法中,溶液A中,单宁酸的质量浓度百分比为1%。
优选地,在上述制备方法中,麦芽糊精的DE值为10-15。麦芽糊精与溶液A的质量比为1g:(4-14)g。
优选地,在上述制备方法中,聚乙烯醇的粘度为20mPa·s-30mPa·s,醇解度为98mol%-99mol%。在溶液C中,聚乙烯醇的质量浓度百分比为5%-15%。
优选地,在上述制备方法中,溶液B和溶液C的质量比为1g:(0.5-2)g。
优选地,在上述制备方法中,在冷冻-解冻循环过程中,冷冻温度为-18℃,冷冻时间为16h-20h,解冻在室温下进行,时间为4h-8h。
本发明的有益效果为:
(1)本发明所制备的酸性体系下麦芽糊精-聚乙烯醇复合水凝胶材料不含有毒或刺激物,具有透气性好、保水性好,防止微生物入侵等优点,能够为创面提供湿润、干净的微环境,并且吸收多余的组织分泌物,从而为伤口提供保护。
(2)本发明以麦芽糊精和聚乙烯醇为主要原料,在生物体内可降解,具有良好的抗菌性,具有良好的生物相容性,可促进胶原形成、肉芽组织生长和上皮细胞增殖等。
(3)本发明制备方法简便,工艺流程稳定,制备的酸性体系下麦芽糊精-聚乙烯醇复合水凝胶材料具有良好的孔隙结构,良好的机械强度。
附图说明
图1所示为实施例3制得的水凝胶的实物图;
图2所示为实施例3制得的水凝胶的SEM图;
图3所示为实施例3制得的水凝胶的红外光谱图;
图4所示为实施例3制得的水凝胶的拉伸性能图;
图5所示为实施例3制得的水凝胶的压缩性能图。
具体实施方式
以下将结合实施例和附图对本发明的构思及产生的技术效果进行清楚、完整的描述,以充分地理解本发明的目的、方案和效果。
实施例1:
一种酸性体系下由麦芽糊精、聚乙烯醇通过物理交联而成的水凝胶敷料。该水凝胶敷料的制备方法的具体步骤如下:
(1)按照单宁酸与去离子水的质量比为1g:99g的比例,将单宁酸加入到去离子水中,室温下搅拌混合均匀,得到酸性溶液A体系;
(2)按照麦芽糊精与溶液A的质量比为1g:4g的比例,将麦芽糊精加入溶液A中,65℃下搅拌混合均匀,得到溶液B;
(3)按照聚乙烯醇与去离子水的质量比为1g:19g的比例,将聚乙烯醇加入去离子水中,95℃下搅拌混合均匀,随后从油浴锅上取下,静置室温后超声进行脱泡处理,得到溶液C;
(4)按照溶液B与溶液C的质量比为1g:2g的比例,将溶液C加入溶液B中,95℃下搅拌混合均匀,得到溶液D;
(5)将溶液D注入模具中,放入冰箱中于-18℃冷冻16h,之后取出样品,在室温下解冻8h,冷冻-解冻循环3次得到麦芽糊精-聚乙烯醇复合水凝胶敷料。
实施例2:
一种酸性体系下由麦芽糊精、聚乙烯醇通过物理交联而成的水凝胶敷料。该水凝胶敷料的制备方法的具体步骤如下:
(1)按照单宁酸与去离子水的质量比为1g:99g的比例,将单宁酸加入到去离子水中,室温下搅拌混合均匀,得到酸性溶液A体系;
(2)按照麦芽糊精与溶液A的质量比为1g:14g的比例,将麦芽糊精加入溶液A中,65℃下搅拌混合均匀,得到溶液B;
(3)按照聚乙烯醇与去离子水的质量比为3g:17g的比例,将聚乙烯醇加入去离子水中,95℃下搅拌混合均匀,随后从油浴锅上取下,静置室温后超声进行脱泡处理,得到溶液C;
(4)按照溶液B与溶液C的质量比为2g:1g的比例,将溶液C加入溶液B中,95℃下搅拌混合均匀,得到溶液D;
(5)将溶液D注入模具中,放入冰箱中于-18℃冷冻18h,之后取出样品,在室温下解冻6h,冷冻-解冻循环3次得到麦芽糊精-聚乙烯醇复合水凝胶敷料。
实施例3:
一种酸性体系下由麦芽糊精、聚乙烯醇通过物理交联而成的水凝胶敷料。该水凝胶敷料的制备方法的具体步骤如下:
(1)按照单宁酸与去离子水的质量比为1g:99g的比例,将单宁酸加入到去离子水中,室温下搅拌混合均匀,得到酸性溶液A体系;
(2)按照麦芽糊精与溶液A的质量比为1g:9g的比例,将麦芽糊精加入溶液A中,65℃下搅拌混合均匀,得到溶液B;
(3)按照聚乙烯醇与去离子水的质量比为1g:9g的比例,将聚乙烯醇加入去离子水中,95℃下搅拌混合均匀,随后从油浴锅上取下,静置室温后超声进行脱泡处理,得到溶液C;
(4)按照溶液B与溶液C的质量比为1g:1g的比例,将溶液C加入溶液B中,95℃下搅拌混合均匀,得到溶液D;
(5)将溶液D注入模具中,放入冰箱中于-18℃冷冻20h,之后取出样品,在室温下解冻4h,冷冻-解冻循环3次得到麦芽糊精-聚乙烯醇复合水凝胶敷料。
图1为本实例得到的麦芽糊精-聚乙烯醇复合水凝胶的实物图,从图中可以看出该水凝胶形状规则,成胶性能良好。图2为本实例得到的麦芽糊精-聚乙烯醇复合水凝胶的SEM图,从图中可以看出该水凝胶孔隙率高,孔隙率越高该材料的保湿性越好。图3为本实例得到的麦芽糊精-聚乙烯醇复合水凝胶的红外光谱图以及麦芽糊精与聚乙烯醇的红外光谱图,由图可以看出并未出现新基团的特征峰,说明该水凝胶是通过物理交联的方式形成的。图4和图5为本实例得到的麦芽糊精-聚乙烯醇复合水凝胶的力学性能图,从图4和图5中可以看出该水凝胶具有良好的拉伸性能与压缩性能。
实施例4:
一种酸性体系下由麦芽糊精、聚乙烯醇通过物理交联而成的水凝胶敷料。该水凝胶敷料的制备方法的具体步骤如下:
(1)按照单宁酸与去离子水的质量比为1g:99g的比例,将单宁酸加入到去离子水中,室温下搅拌混合均匀,得到酸性溶液A体系;
(2)按照麦芽糊精与溶液A的质量比为1g:9g的比例,将麦芽糊精加入溶液A中,65℃下搅拌混合均匀,得到溶液B;
(3)按照聚乙烯醇与去离子水的质量比为1g:9g的比例,将聚乙烯醇加入去离子水中,95℃下搅拌混合均匀,随后从油浴锅上取下,静置室温后超声进行脱泡处理,得到溶液C;
(4)按照溶液B与溶液C的质量比为1g:2g的比例,将溶液C加入溶液B中,95℃下搅拌混合均匀,得到溶液D;
(5)将溶液D注入模具中,放入冰箱中于-18℃冷冻20h,之后取出样品,在室温下解冻4h,冷冻-解冻循环3次得到麦芽糊精-聚乙烯醇复合水凝胶敷料。
实施例5:
一种酸性体系下由麦芽糊精、聚乙烯醇通过物理交联而成的水凝胶敷料。该水凝胶敷料的制备方法的具体步骤如下:
(1)按照单宁酸与去离子水的质量比为1g:99g的比例,将单宁酸加入到去离子水中,室温下搅拌混合均匀,得到酸性溶液A体系;
(2)按照麦芽糊精与溶液A的质量比为1g:9g的比例,将麦芽糊精加入溶液A中,65℃下搅拌混合均匀,得到溶液B;
(3)按照聚乙烯醇与去离子水的质量比为1g:9g的比例,将聚乙烯醇加入去离子水中,95℃下搅拌混合均匀,随后从油浴锅上取下,静置室温后超声进行脱泡处理,得到溶液C;
(4)按照溶液B与溶液C的质量比为2g:1g的比例,将溶液C加入溶液B中,95℃下搅拌混合均匀,得到溶液D;
(5)将溶液D注入模具中,放入冰箱中于-18℃冷冻20h,之后取出样品,在室温下解冻4h,冷冻-解冻循环3次得到麦芽糊精-聚乙烯醇复合水凝胶敷料。
尽管本发明的描述已经相当详尽且特别对几个所述实施例进行了描述,但其并非旨在局限于任何这些细节或实施例或任何特殊实施例,而是应当将其视作是通过参考所附权利要求考虑到现有技术为这些权利要求提供广义的可能性解释,从而有效地涵盖本发明的预定范围。此外,上文以发明人可预见的实施例对本发明进行描述,其目的是为了提供有用的描述,而那些目前尚未预见的对本发明的非实质性改动仍可代表本发明的等效改动。
Claims (10)
1.一种复合水凝胶敷料的制备方法,其特征在于,包括以下步骤:
将单宁酸分散于水中,得到溶液A;随后加入麦芽糊精,于63℃-67℃下搅拌,使其完全溶解,得到溶液B;随后将溶液C加入至溶液B中,于93℃-97℃下搅拌均匀,得到溶液D;然后进行冷冻-解冻循环过程,次数为3-5次;得到麦芽糊精-聚乙烯醇复合水凝胶敷料;
溶液C的得到过程为:将聚乙烯醇加入水中,于93℃-97℃下搅拌,使其完全溶解,冷却至室温后进行脱泡处理,得到溶液C。
2.根据权利要求1所述的制备方法,其特征在于,溶液A中,单宁酸的质量浓度百分比为1%。
3.根据权利要求1所述的制备方法,其特征在于,麦芽糊精的DE值为10-15。
4.根据权利要求1所述的制备方法,其特征在于,麦芽糊精与溶液A的质量比为1g:(4-14)g。
5.根据权利要求1所述的制备方法,其特征在于,聚乙烯醇的粘度为20mPa·s-30mPa·s,醇解度为98mol%-99mol%。
6.根据权利要求1所述的制备方法,其特征在于,在溶液C中,聚乙烯醇的质量浓度百分比为5%-15%。
7.根据权利要求1所述的制备方法,其特征在于,溶液B和溶液C的质量比为1g:(0.5-2)g。
8.根据权利要求1所述的制备方法,其特征在于,在冷冻-解冻循环过程中,冷冻温度为-18℃,冷冻时间为16h-20h。
9.根据权利要求1所述的制备方法,其特征在于,在冷冻-解冻循环过程中,解冻在室温下进行,时间为4h-8h。
10.一种复合水凝胶敷料,其特征在于,由权利要求1至9任一项所述的制备方法制得。
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Citations (7)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US3425972A (en) * | 1963-06-20 | 1969-02-04 | Ledoga Spa | Preparation of water soluble trans parent films from dextrin and polyvinyl alcohol |
WO2004073697A1 (en) * | 2003-02-18 | 2004-09-02 | Scherr George H | Alginate foam compositions |
CN104870535A (zh) * | 2012-12-18 | 2015-08-26 | 于尔戈实验室 | 包含麦芽糊精的新型亲水性聚合物泡沫 |
CN109762182A (zh) * | 2019-01-02 | 2019-05-17 | 大连理工大学 | 一种高强度-多孔结构聚乙烯醇-单宁酸水凝胶的制备方法及应用 |
CN109942905A (zh) * | 2019-03-01 | 2019-06-28 | 昆明理工大学 | 一种复合水凝胶材料及其制备方法 |
CN113679660A (zh) * | 2020-05-19 | 2021-11-23 | 北京智慧客科技创新有限公司 | 一种缓释药物载体及其制备方法和应用 |
CN114344558A (zh) * | 2022-01-20 | 2022-04-15 | 哈尔滨工业大学重庆研究院 | 一种大麻二酚-单宁酸-聚乙烯醇水凝胶伤口敷料及其制备方法 |
-
2022
- 2022-08-11 CN CN202210960246.8A patent/CN115124752A/zh active Pending
Patent Citations (7)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US3425972A (en) * | 1963-06-20 | 1969-02-04 | Ledoga Spa | Preparation of water soluble trans parent films from dextrin and polyvinyl alcohol |
WO2004073697A1 (en) * | 2003-02-18 | 2004-09-02 | Scherr George H | Alginate foam compositions |
CN104870535A (zh) * | 2012-12-18 | 2015-08-26 | 于尔戈实验室 | 包含麦芽糊精的新型亲水性聚合物泡沫 |
CN109762182A (zh) * | 2019-01-02 | 2019-05-17 | 大连理工大学 | 一种高强度-多孔结构聚乙烯醇-单宁酸水凝胶的制备方法及应用 |
CN109942905A (zh) * | 2019-03-01 | 2019-06-28 | 昆明理工大学 | 一种复合水凝胶材料及其制备方法 |
CN113679660A (zh) * | 2020-05-19 | 2021-11-23 | 北京智慧客科技创新有限公司 | 一种缓释药物载体及其制备方法和应用 |
CN114344558A (zh) * | 2022-01-20 | 2022-04-15 | 哈尔滨工业大学重庆研究院 | 一种大麻二酚-单宁酸-聚乙烯醇水凝胶伤口敷料及其制备方法 |
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