EP2930235A4 - Lactobacillus mit fähigkeit zur induzierung der il-12-produktion und verfahren zur kultivierung davon - Google Patents

Lactobacillus mit fähigkeit zur induzierung der il-12-produktion und verfahren zur kultivierung davon

Info

Publication number
EP2930235A4
EP2930235A4 EP13860196.8A EP13860196A EP2930235A4 EP 2930235 A4 EP2930235 A4 EP 2930235A4 EP 13860196 A EP13860196 A EP 13860196A EP 2930235 A4 EP2930235 A4 EP 2930235A4
Authority
EP
European Patent Office
Prior art keywords
lactobacillus
induce
ability
production
culturing same
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
EP13860196.8A
Other languages
English (en)
French (fr)
Other versions
EP2930235A1 (de
EP2930235B1 (de
Inventor
Tatsuhiko Kan
Makoto Ohwaki
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
BIO-LAB Ltd
Japanese Association Of Clinical Research On S
Biogenics Korea Co Ltd
Original Assignee
Biogenics Korea Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Biogenics Korea Co Ltd filed Critical Biogenics Korea Co Ltd
Publication of EP2930235A1 publication Critical patent/EP2930235A1/de
Publication of EP2930235A4 publication Critical patent/EP2930235A4/de
Application granted granted Critical
Publication of EP2930235B1 publication Critical patent/EP2930235B1/de
Active legal-status Critical Current
Anticipated expiration legal-status Critical

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N1/00—Microorganisms, e.g. protozoa; Compositions thereof; Processes of propagating, maintaining or preserving microorganisms or compositions thereof; Processes of preparing or isolating a composition containing a microorganism; Culture media therefor
    • C12N1/38—Chemical stimulation of growth or activity by addition of chemical compounds which are not essential growth factors; Stimulation of growth by removal of a chemical compound
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
    • A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
    • A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
    • A23L33/135—Bacteria or derivatives thereof, e.g. probiotics
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N1/00—Microorganisms, e.g. protozoa; Compositions thereof; Processes of propagating, maintaining or preserving microorganisms or compositions thereof; Processes of preparing or isolating a composition containing a microorganism; Culture media therefor
    • C12N1/04—Preserving or maintaining viable microorganisms
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N1/00—Microorganisms, e.g. protozoa; Compositions thereof; Processes of propagating, maintaining or preserving microorganisms or compositions thereof; Processes of preparing or isolating a composition containing a microorganism; Culture media therefor
    • C12N1/20—Bacteria; Culture media therefor

Landscapes

  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Biotechnology (AREA)
  • Organic Chemistry (AREA)
  • Zoology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Wood Science & Technology (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Medicinal Chemistry (AREA)
  • Biomedical Technology (AREA)
  • Virology (AREA)
  • Biochemistry (AREA)
  • General Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Microbiology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Mycology (AREA)
  • Nutrition Science (AREA)
  • Food Science & Technology (AREA)
  • Polymers & Plastics (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Coloring Foods And Improving Nutritive Qualities (AREA)
EP13860196.8A 2012-12-07 2013-07-22 Lactobacillus mit fähigkeit zur induzierung der il-12-produktion und verfahren zur kultivierung davon Active EP2930235B1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP2012267793 2012-12-07
PCT/KR2013/006528 WO2014088183A1 (ko) 2012-12-07 2013-07-22 Il－12 생산유도능을 갖는 유산균 및 그 제조 방법

Publications (3)

Publication Number Publication Date
EP2930235A1 EP2930235A1 (de) 2015-10-14
EP2930235A4 true EP2930235A4 (de) 2016-08-17
EP2930235B1 EP2930235B1 (de) 2021-03-10

Family

ID=50883583

Family Applications (1)

Application Number Title Priority Date Filing Date
EP13860196.8A Active EP2930235B1 (de) 2012-12-07 2013-07-22 Lactobacillus mit fähigkeit zur induzierung der il-12-produktion und verfahren zur kultivierung davon

Country Status (8)

Country Link
US (1) US20150344841A1 (de)
EP (1) EP2930235B1 (de)
JP (1) JP2014131504A (de)
KR (1) KR101583018B1 (de)
CN (1) CN105026549B (de)
DK (1) DK2930235T3 (de)
ES (1) ES2873951T3 (de)
WO (1) WO2014088183A1 (de)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2016136890A (ja) * 2015-01-28 2016-08-04 株式会社ヤクルト本社 乳酸菌のインターロイキン１０産生誘導能の増強方法
KR102258914B1 (ko) * 2016-07-29 2021-06-02 바이오제닉스코리아 주식회사 항균 마스크
JP6649920B2 (ja) * 2016-08-05 2020-02-19 有限会社バイオ研 免疫調節用組成物、免疫調節用組成物の製造のための使用、免疫調節用組成物の製造方法、該免疫調節用組成物を用いる食品、医薬品、動物食餌製品の製造方法
CN106222125B (zh) * 2016-09-14 2018-10-23 光明乳业股份有限公司 一种植物乳杆菌增殖剂及其应用
KR101794635B1 (ko) * 2016-11-30 2017-11-07 주식회사 락토메이슨 막 필터를 이용한 고농도 사균의 제조방법 및 이의 제조방법으로 제조된 사균
JP6298912B1 (ja) * 2017-04-10 2018-03-20 有限会社バイオ研 乳酸菌の製造方法、及び免疫調節用組成物
KR20230085967A (ko) 2021-12-07 2023-06-15 한전건 나노이온 클러스터 공정으로 코팅한 항균 생리대
CN116650615B (zh) * 2023-07-28 2023-11-03 北京盛美诺生物技术有限公司 一种具有口腔护理功效的组合物及应用

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP2412797A1 (de) * 2009-03-24 2012-02-01 Suntory Holdings Limited Verfahren zur herstellung eines milchsäurebakteriums mit verstärkter immunmodulierender wirkung

Family Cites Families (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP4115181B2 (ja) 2002-07-12 2008-07-09 コンビ株式会社 乳酸菌の免疫賦活効果増強方法
JP2006028047A (ja) * 2004-07-14 2006-02-02 Kikkoman Corp インターロイキン１２産生促進剤およびその製造法
TW200637908A (en) * 2005-01-04 2006-11-01 Calpis Co Ltd Method for preparation of lactic acid bacterium having anti-allergic activity
KR101260533B1 (ko) * 2005-03-03 2013-05-06 가부시키가이샤 메이지 면역기능 조정제
KR100745013B1 (ko) * 2006-01-25 2007-08-10 주식회사 알엔에이 알러지 질환 예방 및 치료를 위한 유산균
CN101454439B (zh) * 2006-05-31 2011-01-26 明治乳业株式会社 免疫调节活性高的乳酸菌的培养法
JP4621218B2 (ja) 2007-02-09 2011-01-26 有限会社バイオ研 Ｔｈ１誘導剤及びその製造方法
JP5243546B2 (ja) * 2008-09-16 2013-07-24 三井化学株式会社 植物由来原料から乳酸を生産する方法及び乳酸生産細菌
JP2010095465A (ja) * 2008-10-16 2010-04-30 House Wellness Foods Kk 乳酸菌含有免疫賦活用組成物
JP2010132579A (ja) * 2008-12-02 2010-06-17 Snow Brand Milk Prod Co Ltd 免疫調節機能を有する乳酸菌
KR101486999B1 (ko) * 2009-07-22 2015-01-28 씨제이제일제당 주식회사 신규한 락토바실러스 플란타룸 및 이를 포함하는 조성물

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP2412797A1 (de) * 2009-03-24 2012-02-01 Suntory Holdings Limited Verfahren zur herstellung eines milchsäurebakteriums mit verstärkter immunmodulierender wirkung

Non-Patent Citations (4)

* Cited by examiner, † Cited by third party
Title
FUJIKI TAKASHI ET AL: "Enhanced immunomodulatory activity and stability in simulated digestive juices of Lactobacillus plantarum L-137 by heat treatment.", BIOSCIENCE, BIOTECHNOLOGY, AND BIOCHEMISTRY 2012, vol. 76, no. 5, 7 May 2012 (2012-05-07), pages 918 - 922, XP002759611, ISSN: 1347-6947 *
IGARASHI TOSHINORI: "Study of the relationship between changes in lactic acid bacterial cell components and stimulation of IL-12 production under salt-stressed conditions.", BIOSCIENCE, BIOTECHNOLOGY, AND BIOCHEMISTRY 2010, vol. 74, no. 11, 2010, pages 2171 - 2175, XP002759610, ISSN: 1347-6947 *
See also references of WO2014088183A1 *
TOSHIHIRO SASHIHARA ET AL: "Effect of growth conditions of Lactobacillus gasseri OLL2809 on the immunostimulatory activity for production of interleukin-12 (p70) by murine splenocytes", INTERNATIONAL JOURNAL OF FOOD MICROBIOLOGY, vol. 120, no. 3, 1 December 2007 (2007-12-01), pages 274 - 281, XP055013338, ISSN: 0168-1605, DOI: 10.1016/j.ijfoodmicro.2007.09.003 *

Also Published As

Publication number Publication date
CN105026549A (zh) 2015-11-04
EP2930235A1 (de) 2015-10-14
JP2014131504A (ja) 2014-07-17
US20150344841A1 (en) 2015-12-03
CN105026549B (zh) 2021-03-16
DK2930235T3 (da) 2021-06-07
ES2873951T3 (es) 2021-11-04
KR20140088501A (ko) 2014-07-10
EP2930235B1 (de) 2021-03-10
WO2014088183A1 (ko) 2014-06-12
KR101583018B1 (ko) 2016-01-06

Similar Documents

Publication Publication Date Title
IL237898A0 (en) Systems for cell culture in 3D, and methods for their preparation and uses
IL236158A0 (en) Methods and compositions to create biomethane
EP2727649A4 (de) Kupfer- und titanhaltige zusammensetzung und verfahren zu ihrer herstellung
EP2680802A4 (de) Saugfähiger artikel und herstellungsverfahren dafür
GB201107863D0 (en) Method and product
EP2930235A4 (de) Lactobacillus mit fähigkeit zur induzierung der il-12-produktion und verfahren zur kultivierung davon
EP2775487A4 (de) Reaktor und herstellungsverfahren dafür
EP2904103A4 (de) Verfahren zur herstellung induzierter pluripotenter stammzellen und deren anwendungen
EP2803721A4 (de) Rekombinanter mikroorganismus mit verbesserter putrescinproduktionsfähigkeit und verfahren zur herstellung putrescin damit
ZA201408690B (en) Oncolytic clostridium ghonii strains, and methods of production and use
EP2851421A4 (de) Nützlicher mikroorganismus und verfahren zur herstellung einer gewünschten substanz
GB201218831D0 (en) Permenter and the method of fermentation
EP2915819A4 (de) Antikörper- und antikörperzusammensetzungsherstellungsverfahren
GB201113610D0 (en) Product and method
GB201118985D0 (en) Product and method
EP2861710A4 (de) Cyclisches biokonversionsverfahren und bioreaktoranordnungen
ZA201308690B (en) Axle and production method
ZA201409446B (en) Syngas fermentation process and medium
EP2905330A4 (de) Zellkultivierungselement und zellkultivierungsverfahren
SG11201507828VA (en) Method for culturing hepatoblast-like cells and culture product thereof
KR101280852B9 (ko) 마 발효물 및 이의 제조 방법
EP2871226A4 (de) Koks und verfahren zur herstellung davon
HUE037681T2 (hu) Fermentálási eljárás
HK1207252A1 (en) Fermented milk product, and method for producing same
HK1207253A1 (en) Fermented milk product, and method for producing same

Legal Events

Date Code Title Description
PUAI Public reference made under article 153(3) epc to a published international application that has entered the european phase

Free format text: ORIGINAL CODE: 0009012

17P Request for examination filed

Effective date: 20150611

AK Designated contracting states

Kind code of ref document: A1

Designated state(s): AL AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LI LT LU LV MC MK MT NL NO PL PT RO RS SE SI SK SM TR

AX Request for extension of the european patent

Extension state: BA ME

DAX Request for extension of the european patent (deleted)
REG Reference to a national code

Ref country code: DE

Ref legal event code: R079

Ref document number: 602013076225

Country of ref document: DE

Free format text: PREVIOUS MAIN CLASS: C12N0001200000

Ipc: C12N0001040000

RA4 Supplementary search report drawn up and despatched (corrected)

Effective date: 20160719

RIC1 Information provided on ipc code assigned before grant

Ipc: C12N 1/38 20060101ALI20160712BHEP

Ipc: C12N 1/04 20060101AFI20160712BHEP

Ipc: C12N 1/20 20060101ALI20160712BHEP

RAP1 Party data changed (applicant data changed or rights of an application transferred)

Owner name: THE JAPANESE ASSOCIATION OF CLINICAL RESEARCH ON S

Owner name: BIO-LAB LTD.

Owner name: BIOGENICS KOREA CO., LTD.

STAA Information on the status of an ep patent application or granted ep patent

Free format text: STATUS: EXAMINATION IS IN PROGRESS

17Q First examination report despatched

Effective date: 20170608

GRAP Despatch of communication of intention to grant a patent

Free format text: ORIGINAL CODE: EPIDOSNIGR1

STAA Information on the status of an ep patent application or granted ep patent

Free format text: STATUS: GRANT OF PATENT IS INTENDED

INTG Intention to grant announced

Effective date: 20200917

RIN1 Information on inventor provided before grant (corrected)

Inventor name: KAN, TATSUHIKO

Inventor name: OHWAKI, MAKOTO

GRAS Grant fee paid

Free format text: ORIGINAL CODE: EPIDOSNIGR3

STAA Information on the status of an ep patent application or granted ep patent

Free format text: STATUS: GRANT OF PATENT IS INTENDED

GRAA (expected) grant

Free format text: ORIGINAL CODE: 0009210

STAA Information on the status of an ep patent application or granted ep patent

Free format text: STATUS: THE PATENT HAS BEEN GRANTED

AK Designated contracting states

Kind code of ref document: B1

Designated state(s): AL AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LI LT LU LV MC MK MT NL NO PL PT RO RS SE SI SK SM TR

REG Reference to a national code

Ref country code: GB

Ref legal event code: FG4D

REG Reference to a national code

Ref country code: AT

Ref legal event code: REF

Ref document number: 1369829

Country of ref document: AT

Kind code of ref document: T

Effective date: 20210315

Ref country code: CH

Ref legal event code: EP

REG Reference to a national code

Ref country code: IE

Ref legal event code: FG4D

REG Reference to a national code

Ref country code: DE

Ref legal event code: R096

Ref document number: 602013076225

Country of ref document: DE

REG Reference to a national code

Ref country code: DK

Ref legal event code: T3

Effective date: 20210603

REG Reference to a national code

Ref country code: NL

Ref legal event code: FP

REG Reference to a national code

Ref country code: SE

Ref legal event code: TRGR

REG Reference to a national code

Ref country code: LT

Ref legal event code: MG9D

PG25 Lapsed in a contracting state [announced via postgrant information from national office to epo]

Ref country code: LT

Free format text: LAPSE BECAUSE OF FAILURE TO SUBMIT A TRANSLATION OF THE DESCRIPTION OR TO PAY THE FEE WITHIN THE PRESCRIBED TIME-LIMIT

Effective date: 20210310

Ref country code: GR

Free format text: LAPSE BECAUSE OF FAILURE TO SUBMIT A TRANSLATION OF THE DESCRIPTION OR TO PAY THE FEE WITHIN THE PRESCRIBED TIME-LIMIT

Effective date: 20210611

Ref country code: FI

Free format text: LAPSE BECAUSE OF FAILURE TO SUBMIT A TRANSLATION OF THE DESCRIPTION OR TO PAY THE FEE WITHIN THE PRESCRIBED TIME-LIMIT

Effective date: 20210310

Ref country code: HR

Free format text: LAPSE BECAUSE OF FAILURE TO SUBMIT A TRANSLATION OF THE DESCRIPTION OR TO PAY THE FEE WITHIN THE PRESCRIBED TIME-LIMIT

Effective date: 20210310

Ref country code: BG

Free format text: LAPSE BECAUSE OF FAILURE TO SUBMIT A TRANSLATION OF THE DESCRIPTION OR TO PAY THE FEE WITHIN THE PRESCRIBED TIME-LIMIT

Effective date: 20210610

Ref country code: NO

Free format text: LAPSE BECAUSE OF FAILURE TO SUBMIT A TRANSLATION OF THE DESCRIPTION OR TO PAY THE FEE WITHIN THE PRESCRIBED TIME-LIMIT

Effective date: 20210610

REG Reference to a national code

Ref country code: AT

Ref legal event code: MK05

Ref document number: 1369829

Country of ref document: AT

Kind code of ref document: T

Effective date: 20210310

PG25 Lapsed in a contracting state [announced via postgrant information from national office to epo]

Ref country code: LV

Free format text: LAPSE BECAUSE OF FAILURE TO SUBMIT A TRANSLATION OF THE DESCRIPTION OR TO PAY THE FEE WITHIN THE PRESCRIBED TIME-LIMIT

Effective date: 20210310

Ref country code: RS

Free format text: LAPSE BECAUSE OF FAILURE TO SUBMIT A TRANSLATION OF THE DESCRIPTION OR TO PAY THE FEE WITHIN THE PRESCRIBED TIME-LIMIT

Effective date: 20210310

PG25 Lapsed in a contracting state [announced via postgrant information from national office to epo]

Ref country code: AT

Free format text: LAPSE BECAUSE OF FAILURE TO SUBMIT A TRANSLATION OF THE DESCRIPTION OR TO PAY THE FEE WITHIN THE PRESCRIBED TIME-LIMIT

Effective date: 20210310

Ref country code: EE

Free format text: LAPSE BECAUSE OF FAILURE TO SUBMIT A TRANSLATION OF THE DESCRIPTION OR TO PAY THE FEE WITHIN THE PRESCRIBED TIME-LIMIT

Effective date: 20210310

Ref country code: CZ

Free format text: LAPSE BECAUSE OF FAILURE TO SUBMIT A TRANSLATION OF THE DESCRIPTION OR TO PAY THE FEE WITHIN THE PRESCRIBED TIME-LIMIT

Effective date: 20210310

Ref country code: SM

Free format text: LAPSE BECAUSE OF FAILURE TO SUBMIT A TRANSLATION OF THE DESCRIPTION OR TO PAY THE FEE WITHIN THE PRESCRIBED TIME-LIMIT

Effective date: 20210310

PG25 Lapsed in a contracting state [announced via postgrant information from national office to epo]

Ref country code: IS

Free format text: LAPSE BECAUSE OF FAILURE TO SUBMIT A TRANSLATION OF THE DESCRIPTION OR TO PAY THE FEE WITHIN THE PRESCRIBED TIME-LIMIT

Effective date: 20210710

Ref country code: PT

Free format text: LAPSE BECAUSE OF FAILURE TO SUBMIT A TRANSLATION OF THE DESCRIPTION OR TO PAY THE FEE WITHIN THE PRESCRIBED TIME-LIMIT

Effective date: 20210712

Ref country code: PL

Free format text: LAPSE BECAUSE OF FAILURE TO SUBMIT A TRANSLATION OF THE DESCRIPTION OR TO PAY THE FEE WITHIN THE PRESCRIBED TIME-LIMIT

Effective date: 20210310

Ref country code: SK

Free format text: LAPSE BECAUSE OF FAILURE TO SUBMIT A TRANSLATION OF THE DESCRIPTION OR TO PAY THE FEE WITHIN THE PRESCRIBED TIME-LIMIT

Effective date: 20210310

Ref country code: RO

Free format text: LAPSE BECAUSE OF FAILURE TO SUBMIT A TRANSLATION OF THE DESCRIPTION OR TO PAY THE FEE WITHIN THE PRESCRIBED TIME-LIMIT

Effective date: 20210310

REG Reference to a national code

Ref country code: DE

Ref legal event code: R097

Ref document number: 602013076225

Country of ref document: DE

PLBE No opposition filed within time limit

Free format text: ORIGINAL CODE: 0009261

STAA Information on the status of an ep patent application or granted ep patent

Free format text: STATUS: NO OPPOSITION FILED WITHIN TIME LIMIT

PG25 Lapsed in a contracting state [announced via postgrant information from national office to epo]

Ref country code: AL

Free format text: LAPSE BECAUSE OF FAILURE TO SUBMIT A TRANSLATION OF THE DESCRIPTION OR TO PAY THE FEE WITHIN THE PRESCRIBED TIME-LIMIT

Effective date: 20210310

26N No opposition filed

Effective date: 20211213

PG25 Lapsed in a contracting state [announced via postgrant information from national office to epo]

Ref country code: SI

Free format text: LAPSE BECAUSE OF FAILURE TO SUBMIT A TRANSLATION OF THE DESCRIPTION OR TO PAY THE FEE WITHIN THE PRESCRIBED TIME-LIMIT

Effective date: 20210310

REG Reference to a national code

Ref country code: CH

Ref legal event code: PL

PG25 Lapsed in a contracting state [announced via postgrant information from national office to epo]

Ref country code: MC

Free format text: LAPSE BECAUSE OF FAILURE TO SUBMIT A TRANSLATION OF THE DESCRIPTION OR TO PAY THE FEE WITHIN THE PRESCRIBED TIME-LIMIT

Effective date: 20210310

REG Reference to a national code

Ref country code: BE

Ref legal event code: MM

Effective date: 20210731

PG25 Lapsed in a contracting state [announced via postgrant information from national office to epo]

Ref country code: LI

Free format text: LAPSE BECAUSE OF NON-PAYMENT OF DUE FEES

Effective date: 20210731

Ref country code: CH

Free format text: LAPSE BECAUSE OF NON-PAYMENT OF DUE FEES

Effective date: 20210731

PG25 Lapsed in a contracting state [announced via postgrant information from national office to epo]

Ref country code: IS

Free format text: LAPSE BECAUSE OF FAILURE TO SUBMIT A TRANSLATION OF THE DESCRIPTION OR TO PAY THE FEE WITHIN THE PRESCRIBED TIME-LIMIT

Effective date: 20210710

Ref country code: LU

Free format text: LAPSE BECAUSE OF NON-PAYMENT OF DUE FEES

Effective date: 20210722

PG25 Lapsed in a contracting state [announced via postgrant information from national office to epo]

Ref country code: IE

Free format text: LAPSE BECAUSE OF NON-PAYMENT OF DUE FEES

Effective date: 20210722

Ref country code: BE

Free format text: LAPSE BECAUSE OF NON-PAYMENT OF DUE FEES

Effective date: 20210731

PG25 Lapsed in a contracting state [announced via postgrant information from national office to epo]

Ref country code: HU

Free format text: LAPSE BECAUSE OF FAILURE TO SUBMIT A TRANSLATION OF THE DESCRIPTION OR TO PAY THE FEE WITHIN THE PRESCRIBED TIME-LIMIT; INVALID AB INITIO

Effective date: 20130722

PG25 Lapsed in a contracting state [announced via postgrant information from national office to epo]

Ref country code: CY

Free format text: LAPSE BECAUSE OF FAILURE TO SUBMIT A TRANSLATION OF THE DESCRIPTION OR TO PAY THE FEE WITHIN THE PRESCRIBED TIME-LIMIT

Effective date: 20210310

PGFP Annual fee paid to national office [announced via postgrant information from national office to epo]

Ref country code: ES

Payment date: 20240131

Year of fee payment: 11

PG25 Lapsed in a contracting state [announced via postgrant information from national office to epo]

Ref country code: MK

Free format text: LAPSE BECAUSE OF FAILURE TO SUBMIT A TRANSLATION OF THE DESCRIPTION OR TO PAY THE FEE WITHIN THE PRESCRIBED TIME-LIMIT

Effective date: 20210310

PGFP Annual fee paid to national office [announced via postgrant information from national office to epo]

Ref country code: SE

Payment date: 20240130

Year of fee payment: 11

Ref country code: IT

Payment date: 20240130

Year of fee payment: 11

PG25 Lapsed in a contracting state [announced via postgrant information from national office to epo]

Ref country code: TR

Free format text: LAPSE BECAUSE OF FAILURE TO SUBMIT A TRANSLATION OF THE DESCRIPTION OR TO PAY THE FEE WITHIN THE PRESCRIBED TIME-LIMIT

Effective date: 20210310

PGFP Annual fee paid to national office [announced via postgrant information from national office to epo]

Ref country code: NL

Payment date: 20240719

Year of fee payment: 12

PG25 Lapsed in a contracting state [announced via postgrant information from national office to epo]

Ref country code: MT

Free format text: LAPSE BECAUSE OF FAILURE TO SUBMIT A TRANSLATION OF THE DESCRIPTION OR TO PAY THE FEE WITHIN THE PRESCRIBED TIME-LIMIT

Effective date: 20210310

PGFP Annual fee paid to national office [announced via postgrant information from national office to epo]

Ref country code: DE

Payment date: 20240927

Year of fee payment: 12

PGFP Annual fee paid to national office [announced via postgrant information from national office to epo]

Ref country code: DK

Payment date: 20240726

Year of fee payment: 12

PGFP Annual fee paid to national office [announced via postgrant information from national office to epo]

Ref country code: GB

Payment date: 20240725

Year of fee payment: 12

PGFP Annual fee paid to national office [announced via postgrant information from national office to epo]

Ref country code: FR

Payment date: 20240730

Year of fee payment: 12