EP2879966A1 - Flüssigkeitsausgabekopf, im besonderen für eine flasche zum verpacken einer flüssigkeit mit tropfenspender - Google Patents
Flüssigkeitsausgabekopf, im besonderen für eine flasche zum verpacken einer flüssigkeit mit tropfenspenderInfo
- Publication number
- EP2879966A1 EP2879966A1 EP13773332.5A EP13773332A EP2879966A1 EP 2879966 A1 EP2879966 A1 EP 2879966A1 EP 13773332 A EP13773332 A EP 13773332A EP 2879966 A1 EP2879966 A1 EP 2879966A1
- Authority
- EP
- European Patent Office
- Prior art keywords
- liquid
- bottle
- dispensing head
- membrane
- tubular
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 239000007788 liquid Substances 0.000 title claims abstract description 136
- 238000004806 packaging method and process Methods 0.000 title description 4
- 239000012528 membrane Substances 0.000 claims abstract description 72
- 230000002209 hydrophobic effect Effects 0.000 claims abstract description 40
- 238000001914 filtration Methods 0.000 claims abstract description 26
- 241000894006 Bacteria Species 0.000 claims abstract description 3
- 238000009826 distribution Methods 0.000 claims description 16
- 230000001580 bacterial effect Effects 0.000 claims description 10
- 238000000605 extraction Methods 0.000 claims description 6
- 238000007789 sealing Methods 0.000 claims description 3
- 230000001681 protective effect Effects 0.000 claims description 2
- 239000000356 contaminant Substances 0.000 claims 1
- 239000000463 material Substances 0.000 abstract description 11
- 210000004379 membrane Anatomy 0.000 description 59
- 210000003128 head Anatomy 0.000 description 33
- 239000006196 drop Substances 0.000 description 16
- 230000005661 hydrophobic surface Effects 0.000 description 7
- 230000000694 effects Effects 0.000 description 6
- 239000000243 solution Substances 0.000 description 5
- 238000005187 foaming Methods 0.000 description 4
- 230000005660 hydrophilic surface Effects 0.000 description 4
- 239000002245 particle Substances 0.000 description 4
- 238000009792 diffusion process Methods 0.000 description 3
- 229940012356 eye drops Drugs 0.000 description 3
- 210000000887 face Anatomy 0.000 description 3
- 239000012530 fluid Substances 0.000 description 3
- 238000004519 manufacturing process Methods 0.000 description 3
- 244000005700 microbiome Species 0.000 description 3
- 210000004400 mucous membrane Anatomy 0.000 description 3
- 239000002997 ophthalmic solution Substances 0.000 description 3
- 230000035515 penetration Effects 0.000 description 3
- 230000035699 permeability Effects 0.000 description 3
- -1 polyethylene Polymers 0.000 description 3
- 239000003755 preservative agent Substances 0.000 description 3
- 230000002441 reversible effect Effects 0.000 description 3
- 239000004698 Polyethylene Substances 0.000 description 2
- 230000015572 biosynthetic process Effects 0.000 description 2
- 238000004891 communication Methods 0.000 description 2
- 230000006835 compression Effects 0.000 description 2
- 238000007906 compression Methods 0.000 description 2
- 230000003750 conditioning effect Effects 0.000 description 2
- 238000011109 contamination Methods 0.000 description 2
- 239000000428 dust Substances 0.000 description 2
- 239000007791 liquid phase Substances 0.000 description 2
- 238000002156 mixing Methods 0.000 description 2
- 239000000203 mixture Substances 0.000 description 2
- 229940054534 ophthalmic solution Drugs 0.000 description 2
- 230000002093 peripheral effect Effects 0.000 description 2
- 239000012071 phase Substances 0.000 description 2
- 239000004033 plastic Substances 0.000 description 2
- 229920003023 plastic Polymers 0.000 description 2
- 229920000573 polyethylene Polymers 0.000 description 2
- 230000002829 reductive effect Effects 0.000 description 2
- 239000011347 resin Substances 0.000 description 2
- 229920005989 resin Polymers 0.000 description 2
- 238000000926 separation method Methods 0.000 description 2
- 239000012815 thermoplastic material Substances 0.000 description 2
- 239000004480 active ingredient Substances 0.000 description 1
- 230000000844 anti-bacterial effect Effects 0.000 description 1
- 239000007864 aqueous solution Substances 0.000 description 1
- 239000003899 bactericide agent Substances 0.000 description 1
- 230000001588 bifunctional effect Effects 0.000 description 1
- 239000000470 constituent Substances 0.000 description 1
- 238000010276 construction Methods 0.000 description 1
- 239000002537 cosmetic Substances 0.000 description 1
- 230000009189 diving Effects 0.000 description 1
- 238000000203 droplet dispensing Methods 0.000 description 1
- 239000003889 eye drop Substances 0.000 description 1
- 238000011049 filling Methods 0.000 description 1
- 230000004907 flux Effects 0.000 description 1
- 239000006260 foam Substances 0.000 description 1
- 238000001033 granulometry Methods 0.000 description 1
- 238000010438 heat treatment Methods 0.000 description 1
- 238000003780 insertion Methods 0.000 description 1
- 230000037431 insertion Effects 0.000 description 1
- 230000007794 irritation Effects 0.000 description 1
- 238000007726 management method Methods 0.000 description 1
- 238000000034 method Methods 0.000 description 1
- 230000036961 partial effect Effects 0.000 description 1
- 230000000149 penetrating effect Effects 0.000 description 1
- 229920000642 polymer Polymers 0.000 description 1
- 229920000098 polyolefin Polymers 0.000 description 1
- 239000011148 porous material Substances 0.000 description 1
- 238000004321 preservation Methods 0.000 description 1
- 230000002335 preservative effect Effects 0.000 description 1
- 238000003825 pressing Methods 0.000 description 1
- 230000035755 proliferation Effects 0.000 description 1
- 230000001105 regulatory effect Effects 0.000 description 1
- 229910052709 silver Inorganic materials 0.000 description 1
- 239000004332 silver Substances 0.000 description 1
- 238000005245 sintering Methods 0.000 description 1
- 230000002269 spontaneous effect Effects 0.000 description 1
- 238000003860 storage Methods 0.000 description 1
- 239000004094 surface-active agent Substances 0.000 description 1
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 1
- 238000004804 winding Methods 0.000 description 1
Classifications
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B65—CONVEYING; PACKING; STORING; HANDLING THIN OR FILAMENTARY MATERIAL
- B65D—CONTAINERS FOR STORAGE OR TRANSPORT OF ARTICLES OR MATERIALS, e.g. BAGS, BARRELS, BOTTLES, BOXES, CANS, CARTONS, CRATES, DRUMS, JARS, TANKS, HOPPERS, FORWARDING CONTAINERS; ACCESSORIES, CLOSURES, OR FITTINGS THEREFOR; PACKAGING ELEMENTS; PACKAGES
- B65D83/00—Containers or packages with special means for dispensing contents
- B65D83/0094—Containers having an external wall formed as, or with, a diaphragm or the like which is deformed to expel the contents
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B65—CONVEYING; PACKING; STORING; HANDLING THIN OR FILAMENTARY MATERIAL
- B65D—CONTAINERS FOR STORAGE OR TRANSPORT OF ARTICLES OR MATERIALS, e.g. BAGS, BARRELS, BOTTLES, BOXES, CANS, CARTONS, CRATES, DRUMS, JARS, TANKS, HOPPERS, FORWARDING CONTAINERS; ACCESSORIES, CLOSURES, OR FITTINGS THEREFOR; PACKAGING ELEMENTS; PACKAGES
- B65D47/00—Closures with filling and discharging, or with discharging, devices
- B65D47/04—Closures with discharging devices other than pumps
- B65D47/06—Closures with discharging devices other than pumps with pouring spouts or tubes; with discharge nozzles or passages
- B65D47/18—Closures with discharging devices other than pumps with pouring spouts or tubes; with discharge nozzles or passages for discharging drops; Droppers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61J—CONTAINERS SPECIALLY ADAPTED FOR MEDICAL OR PHARMACEUTICAL PURPOSES; DEVICES OR METHODS SPECIALLY ADAPTED FOR BRINGING PHARMACEUTICAL PRODUCTS INTO PARTICULAR PHYSICAL OR ADMINISTERING FORMS; DEVICES FOR ADMINISTERING FOOD OR MEDICINES ORALLY; BABY COMFORTERS; DEVICES FOR RECEIVING SPITTLE
- A61J1/00—Containers specially adapted for medical or pharmaceutical purposes
- A61J1/05—Containers specially adapted for medical or pharmaceutical purposes for collecting, storing or administering blood, plasma or medical fluids ; Infusion or perfusion containers
- A61J1/06—Ampoules or carpules
- A61J1/065—Rigid ampoules, e.g. glass ampoules
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61J—CONTAINERS SPECIALLY ADAPTED FOR MEDICAL OR PHARMACEUTICAL PURPOSES; DEVICES OR METHODS SPECIALLY ADAPTED FOR BRINGING PHARMACEUTICAL PRODUCTS INTO PARTICULAR PHYSICAL OR ADMINISTERING FORMS; DEVICES FOR ADMINISTERING FOOD OR MEDICINES ORALLY; BABY COMFORTERS; DEVICES FOR RECEIVING SPITTLE
- A61J1/00—Containers specially adapted for medical or pharmaceutical purposes
- A61J1/14—Details; Accessories therefor
- A61J1/1412—Containers with closing means, e.g. caps
- A61J1/1418—Threaded type
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61J—CONTAINERS SPECIALLY ADAPTED FOR MEDICAL OR PHARMACEUTICAL PURPOSES; DEVICES OR METHODS SPECIALLY ADAPTED FOR BRINGING PHARMACEUTICAL PRODUCTS INTO PARTICULAR PHYSICAL OR ADMINISTERING FORMS; DEVICES FOR ADMINISTERING FOOD OR MEDICINES ORALLY; BABY COMFORTERS; DEVICES FOR RECEIVING SPITTLE
- A61J1/00—Containers specially adapted for medical or pharmaceutical purposes
- A61J1/14—Details; Accessories therefor
- A61J1/1443—Containers with means for dispensing liquid medicaments in a filtered or sterile way, e.g. with bacterial filters
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61J—CONTAINERS SPECIALLY ADAPTED FOR MEDICAL OR PHARMACEUTICAL PURPOSES; DEVICES OR METHODS SPECIALLY ADAPTED FOR BRINGING PHARMACEUTICAL PRODUCTS INTO PARTICULAR PHYSICAL OR ADMINISTERING FORMS; DEVICES FOR ADMINISTERING FOOD OR MEDICINES ORALLY; BABY COMFORTERS; DEVICES FOR RECEIVING SPITTLE
- A61J1/00—Containers specially adapted for medical or pharmaceutical purposes
- A61J1/14—Details; Accessories therefor
- A61J1/1443—Containers with means for dispensing liquid medicaments in a filtered or sterile way, e.g. with bacterial filters
- A61J1/145—Containers with means for dispensing liquid medicaments in a filtered or sterile way, e.g. with bacterial filters using air filters
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61J—CONTAINERS SPECIALLY ADAPTED FOR MEDICAL OR PHARMACEUTICAL PURPOSES; DEVICES OR METHODS SPECIALLY ADAPTED FOR BRINGING PHARMACEUTICAL PRODUCTS INTO PARTICULAR PHYSICAL OR ADMINISTERING FORMS; DEVICES FOR ADMINISTERING FOOD OR MEDICINES ORALLY; BABY COMFORTERS; DEVICES FOR RECEIVING SPITTLE
- A61J1/00—Containers specially adapted for medical or pharmaceutical purposes
- A61J1/14—Details; Accessories therefor
- A61J1/1443—Containers with means for dispensing liquid medicaments in a filtered or sterile way, e.g. with bacterial filters
- A61J1/1456—Containers with means for dispensing liquid medicaments in a filtered or sterile way, e.g. with bacterial filters using liquid filters
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61J—CONTAINERS SPECIALLY ADAPTED FOR MEDICAL OR PHARMACEUTICAL PURPOSES; DEVICES OR METHODS SPECIALLY ADAPTED FOR BRINGING PHARMACEUTICAL PRODUCTS INTO PARTICULAR PHYSICAL OR ADMINISTERING FORMS; DEVICES FOR ADMINISTERING FOOD OR MEDICINES ORALLY; BABY COMFORTERS; DEVICES FOR RECEIVING SPITTLE
- A61J1/00—Containers specially adapted for medical or pharmaceutical purposes
- A61J1/14—Details; Accessories therefor
- A61J1/1475—Inlet or outlet ports
- A61J1/1481—Inlet or outlet ports with connection retaining means, e.g. thread or snap-fit
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61J—CONTAINERS SPECIALLY ADAPTED FOR MEDICAL OR PHARMACEUTICAL PURPOSES; DEVICES OR METHODS SPECIALLY ADAPTED FOR BRINGING PHARMACEUTICAL PRODUCTS INTO PARTICULAR PHYSICAL OR ADMINISTERING FORMS; DEVICES FOR ADMINISTERING FOOD OR MEDICINES ORALLY; BABY COMFORTERS; DEVICES FOR RECEIVING SPITTLE
- A61J1/00—Containers specially adapted for medical or pharmaceutical purposes
- A61J1/14—Details; Accessories therefor
- A61J1/20—Arrangements for transferring or mixing fluids, e.g. from vial to syringe
- A61J1/2003—Accessories used in combination with means for transfer or mixing of fluids, e.g. for activating fluid flow, separating fluids, filtering fluid or venting
- A61J1/2068—Venting means
- A61J1/2075—Venting means for external venting
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61J—CONTAINERS SPECIALLY ADAPTED FOR MEDICAL OR PHARMACEUTICAL PURPOSES; DEVICES OR METHODS SPECIALLY ADAPTED FOR BRINGING PHARMACEUTICAL PRODUCTS INTO PARTICULAR PHYSICAL OR ADMINISTERING FORMS; DEVICES FOR ADMINISTERING FOOD OR MEDICINES ORALLY; BABY COMFORTERS; DEVICES FOR RECEIVING SPITTLE
- A61J1/00—Containers specially adapted for medical or pharmaceutical purposes
- A61J1/14—Details; Accessories therefor
- A61J1/20—Arrangements for transferring or mixing fluids, e.g. from vial to syringe
- A61J1/2003—Accessories used in combination with means for transfer or mixing of fluids, e.g. for activating fluid flow, separating fluids, filtering fluid or venting
- A61J1/2079—Filtering means
- A61J1/2082—Filtering means for gas filtration
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61J—CONTAINERS SPECIALLY ADAPTED FOR MEDICAL OR PHARMACEUTICAL PURPOSES; DEVICES OR METHODS SPECIALLY ADAPTED FOR BRINGING PHARMACEUTICAL PRODUCTS INTO PARTICULAR PHYSICAL OR ADMINISTERING FORMS; DEVICES FOR ADMINISTERING FOOD OR MEDICINES ORALLY; BABY COMFORTERS; DEVICES FOR RECEIVING SPITTLE
- A61J1/00—Containers specially adapted for medical or pharmaceutical purposes
- A61J1/14—Details; Accessories therefor
- A61J1/20—Arrangements for transferring or mixing fluids, e.g. from vial to syringe
- A61J1/2003—Accessories used in combination with means for transfer or mixing of fluids, e.g. for activating fluid flow, separating fluids, filtering fluid or venting
- A61J1/2079—Filtering means
- A61J1/2086—Filtering means for fluid filtration
Definitions
- the present invention relates to a liquid dispensing head from a bottle on which it is mounted. It relates more particularly to the design of drip dispensing bottles used in the pharmaceutical industry, but also the design of such bottles for cosmetics or parapharmacy, and more broadly for any industry with similar needs in the pharmaceutical industry. field of liquid distribution.
- Liquid distribution heads comprise permselective membranes arranged inside a mounting body in the neck of a receiver bottle of a liquid to be dispensed, across the path of the expelled liquid and that of the air sucked in replacement.
- these membranes can play several roles.
- a membrane having properties equivalent to those with mesh sizes of less than 0.2 microns will function as a bacterial filtration membrane preserving the content remaining in the bottle of any bacterial contamination coming from the outside air called in. enter the bottle.
- a membrane of hydrophilic material will tend to remain impregnated with an aqueous liquid having passed through it during the expulsion of a drop and thus become impervious to air, while Hydrophobic membrane will be easily passed through the air until the pressure equilibrium between the two faces of the membrane.
- the invention aims at proposing an alternative to previous conventional designs by proposing distribution heads in which it is intended to modify the design and arrangement of the semi-permeable membrane so as to improve the conditions under which the management is ensured. exchanges of fluids between the inside and the outside of the bottle according to a differential pressure between its two faces. It also aims to broaden the possibilities of application of the technique, and more specifically, in its preferred embodiments, to allow the dropwise distribution of viscous solutions preserved sterile.
- the present invention consists in its principle in arranging the semi-permeable membrane in the longitudinal direction of the bottle rather than in the transverse direction as has been done hitherto.
- the interface between liquid and air is maintained, at least at the level of the membrane with selective permeability to water (more generally to the liquid to be dispensed) in the presence of air, by configuring the membrane around one or more conduits in communication with the outside which dive into the bottle.
- flexible tubes are used whose walls are made of the material of the membrane and whose ends open out of the bottle, preferably through a perforated plate for mounting the assembly across the neck of the liquid reservoir flask.
- dispensing which surrounds their respective ends in a sealed manner by stiffening their walls so as to preserve the outlet of their internal conduits by individualized outlets.
- the membrane which manages the alternation of the flows passing through the distribution head as a function of the pressures prevailing on either side, in the form of tubular filters with selective permeability properties, which function either by extracting the liquid out of the bottle for its diffusion, or by entering the outside air into the bottle in compensation for the expelled liquid.
- the dispensing head according to the invention with the longitudinal arrangement of the tubular filters that it comprises, makes it possible to have a large active surface in selective permeability, which no longer knows the dimensional limits which are linked, in the current bottles, to the diameter of the head of the bottle across of which the membrane is arranged. This feature is of importance especially for the liquid expulsion function, while the particle filtration capacity is especially sought from the active air suction membrane surface.
- a bacterial filtration membrane will have a protective role for a liquid that is kept sterile in the vial. There is no need for the latter to contain a preservative agent.
- a preservative agent it is known that the presence of a preservative in the composition of the product to be distributed entails risks of side effects, in terms of irritation of the mucous membranes, for example in the case of ophthalmic drops, or in the case of other zones. sensitive of the body, in dermatology in particular.
- liquid-permeable activated filtering surface makes it possible to reduce the pressure that it is necessary to exert on the walls of the bottle in order to expel the liquid, since the functional surface is larger. So also, it ⁇ facilitates the use in the liquid vial conmatess viscous solutions.
- Another advantage lies in the fact that freedom is gained in the extent and arrangement of membrane regions which are hydrophilic or functionally hydrophobic functional respectively. It is certainly conceivable to have hydrophilic areas and hydrophobic zones along the same tube, but it appears simpler in manufacture and more effective in operation to reserve the hydrophilic character to some of the tubular conduits (for operation in extraction of liquid) and reserve the hydrophobic character for other tubular ducts (for operation in air intake). In this way, no mixing between the liquid phase and the gas phase can occur there.
- tubular duct in the broad sense is not necessarily folded back on itself, but that it may as well be tubes closed at the end and having a single end opening out of the reservoir bottle. liquid.
- the filter assembly has antibacterial properties, and filter surfaces are hydrophilic and reserved for the extraction of the liquid while filter surfaces are hydrophobic and reserved for the entry of 'air. So that, when the flask is returned to deliver a drop, the air does not enter the bottle before the liquid outlet, it is generally desirable that the hydrophobic surfaces are arranged close to the mounting plate of the assembly which closes the axial passage of the annular body of the common distribution head to the liquid and to the air and that the hydrophilic surfaces extend longitudinally deeper into the liquid reservoir bottle. The hydrophobic surfaces thus bathe in liquid when the bottle is inverted, which prevents the passage of air.
- the arrangements thus implemented according to the invention have the advantage of making it possible to regulate separately the extent of the areas reserved for the extraction of the liquid and the extent of the surfaces reserved for the entry of air, as well as that their respective provisions, more or less plunging deep into the bottle or more or less cantoned near the neck of the bottle.
- the liquid extraction ducts are distinct from the air inlet ducts, any mixing between the liquid phase and the gas phase is avoided in the course of these operations, which is particularly useful when, for example, the nature of its active ingredient or the presence of a surfactant in its composition, the liquid to be diffused is likely to generate a foaming phenomenon in contact with the air.
- the separation of the functions of the conduits and the freedom of their positioning in the bottle advantageously combine in such an application to the diffusion of foaming products.
- the separation of physical order between the air passage and the passage of the liquid makes it possible to individually regulate the flows proper to the two fluids, this also makes it possible to dispense with the need for the porous flux regulating buffer.
- the vials according to the invention become all the more advantageous for the distribution of foaming products, since the porous buffer is itself a foam producer in this case.
- the quality of protection of the liquid against the penetration of bacterial contamination is excellent. Only the ends of the tubes are flush on the outside, where they are open for the exit of the liquid. The free surface of liquid exposed to the outside is extremely low. On the other hand, the liquid that has passed through the membrane and remains in the tubes is confined in thin columns, which allow neither the diffusion of contaminated plots of liquid nor the bacterial proliferation from them.
- the sleeve surrounding the membrane tubes consists of a non-perforated tubular wall, it serves on the other hand to guide the circulation of the liquid which, during a distribution of drops, is pushed through it. in order to encourage the liquid to lick the walls of the membrane tubes while passing around them in a calm circulation mode.
- the sheath can advantageously be provided to give the sheath an external configuration facilitating a sealed contact with the neck of the bottle.
- Other provisions affecting the sheath meet the need to make possible the useful consumption of all the liquid content of the bottle.
- this window is advantageously provided a window through the tubular wall of the sleeve just below the base of the terminal dropper tip. It allows the passage of the liquid inside the sleeve when there is only a little liquid in the bottle and this liquid meets outside the sleeve in the bottle turned upside down.
- this window can be used for the penetration of the air to enter the bottle when releasing the pressure on the walls of the bottle by returning it to the normal upright position after the expulsion of a drop of liquid.
- FIG. 1 shows, in a partial sectional view, a bottle thus equipped in a first embodiment
- FIG. 2 represents an exploded view of constituent elements of the bottle illustrated in FIG. 1, and in particular a sheath, tubular filters and a diffuser buffer;
- FIG. 3 shows a sectional view of a bottle equipped with a drip distribution head according to a second embodiment.
- the invention will be described in accordance with these figures, and it will be understood that the characteristics of each of the embodiments may be combined to obtain a dispensing head according to the invention, adapted to be mounted on a liquid reservoir bottle and comprising a filtering device arranged across the neck of the bottle to interface between the inside and the outside of the bottle, on the path common to the liquid to the expulsion and to the external air sucked alternately .
- a dispensing head 1 according to a first embodiment of the invention is illustrated in FIG. 1, mounted in a liquid conditioning bottle 2.
- the elements that make up the bottle, and in particular the dispensing head consist generally of a plastic material compatible with the application for the preservation of an ophthalmic solution. They are each made of polymer of the family of polyolefins, especially polyethylene.
- the bottle comprises a liquid storage tank 4 whose cylindrical peripheral wall 6 is elastically reversible deformation, so as to allow a distribution of the liquid from a manual compression exerted on this wall by the user and a return spontaneous to its original shape by admission of air in compensation for the liquid released when this manual compression is released.
- the return air in compensation is performed in the reverse path of the outlet of each drop of liquid, through the dispensing head, here through the cylindrical bore 8 internal to the body of the dispensing head, which is annular shape.
- the cylindrical wall of the bottle has at its free end a throttling portion which is extended axially by a neck 10, wherein the dispensing head is fixed in sealed connection.
- a removable cap 12 for closing the dispensing head is screwed in a conventional manner around the neck of the bottle.
- the cap is formed of a hollow cylinder closed at one end and having inside the cylinder a concentric chimney 14.
- the dispensing head forms a dropper tip 16, terminating its cylindrical annular body 17 outside the bottle.
- the body 17 has a flange 18 which extends radially outwardly the cylindrical wall.
- a throat is formed by a shoulder 20 so as to form an outlet port 22. of smaller diameter and a shoulder inside the tip.
- a porous pad 24 is disposed at the end of the tip against this shoulder by filling the entire passage opening.
- the pad is made of a porous thermoplastic material based on polyethylene conferring a hydrophobic character which avoids the stagnation of liquid and which promotes the entry of air when the pad dries. It is obtained by sintering, that is to say by heat treatment of particles of thermoplastic material, and it may contain a bactericidal agent, consisting for example of silver ions known to be effective on many bacterial strains present on the skin and the ocular mucous membranes.
- the porous buffer has porosity characteristics capable of achieving a splitter effect with respect to the liquid exiting the bottle without substantially curbing its circulation, so as to form a droplet in expulsion. We can play on the diameter of the terminal orifice to define the size of the drop.
- a filter device with semi-permeable membranes 26 is disposed inside the dispensing head. It comprises, on the one hand, a set of tubular filters, one with a hydrophobic semi-permeable wall and the other with a hydrophilic semi-permeable wall, and on the other hand an organic resin plate overmolded around the open ends of the tubular filters used for mounting the assembly across the nozzle 17 forming the body of the liquid dispensing head.
- This plate 28 is arranged transversely in the tip, in sealing contact with the inner wall of the latter on all its around, while the various tubular filters are adapted to dip from it into the liquid reservoir bottle.
- the set of tubular filters comprises filters 30 folded on themselves so as to have a U-shape, and an additional filter 32 wound in a spiral around the U-shaped filters.
- the U-folded filters extend longitudinally in the bottle at a distance farther from the plate than the additional spiral filter, while the latter remains closer to the plate, away from the liquid when the bottle is placed. vertical at rest.
- Each tubular filter has a wall in the form of a semi-permeable membrane.
- the spirally wound tubular filter 32 is formed of a semipermeable membrane tube of hydrophobic material, thus selectively permeable to air and not to liquid, while the tubular filters extending longitudinally in the bottle are respectively formed of a membrane of hydrophilic material, so that they are selectively permeable to the liquid in the presence of air.
- each of these filters is a semi-permeable membrane tube open at its ends 31, said ends being open through the plate 28 on the side of the upper face of the plate which is covered by the distribution buffer 24, opposite the tank 4. It can thus be seen that all the open ends 31 of the tubular filters 30, 32 of the filtering device are disposed on the same side of the plate 28, that is to say on the of the outlet channel, and that these tubular filters do not have an open end on the side of the tank.
- the porosity or mesh size of the membrane constituting the wall of the tubular filters which determines the particulate filtration capacity, may be different depending on whether it is wall pipes.
- Hydrophobic membrane reserved for the aspiration of air or hydrophilic wall tubes reserved for the expulsion of liquid. So, while now a 0.2 micron bacterial filtration capacity for the air inlet membrane, in order to maintain a sterile medium inside the flask, we can settle for a coarser particle size filtration for the membrane of the tubes serving as liquid outlet.
- the major advantage is to be able to use the vial for ophthalmic solutions of viscous consistency without having to excessively increase the pressure to be exerted to force the liquid to pass through the hydrophilic membrane, which is also a function of the semicircular surface area. permeable to the liquid available.
- the acceptable viscosity can be set in compromise with the ability of the liquid impregnated membrane to become airtight so that, without going to the finesse necessary to filter the bacteria, the membrane does not let the contaminating microorganisms from outside air, assuming they reach it.
- the porous buffer 24 contributes to the protection of a sterile content of the bottle by its filtering role with regard to the dust and equivalent particles present in the outside air, which it prevents from reaching up to the entrance of ducts internal to the tubular filters, with the contaminating micro-organisms that they could convey.
- the same buffer prevents any direct contact between the skin or mucous membranes of the user and the plate 28 on the surface of which these conduits open. In total we ensure a good air filtration that allows the vial to an ophthalmic solution without preservatives.
- a sheath 34 extends perpendicular to the plate inside the liquid reservoir flask, where it has a hollow internal diameter shape adapted to receive the longitudinal filter tubes to serve as an extension guide. Moreover, the sleeve serves as a support for winding the spiral tube.
- the sheath is open at both longitudinal ends. At one of its ends, it is secured to the perforated plate 28 serving as a support for all the tubular filters, for example during the manufacture by overmoulding of the resin plate on the tubes.
- the sleeve has a liquid passage window 36 formed in its wall, close to the end adapted to be in contact with the transverse plate. It is made of a rigid plastic material, which provides protection for the tubes received inside and which guards the liquid penetrating the sheath by its open free end and the window.
- the arrangement of the filters and the sleeve is such that the tubular filter with hydrophobic wall 32 is located between the plate and the window of the sleeve.
- the advantage of such an arrangement is in particular to prevent too much liquid remains stuck in the bottle without being able to leave the end of use of the bottle.
- the tampon 24 is first inserted inside the body of the nozzle, pushing it from the end of the larger diameter to the stop formed by the shoulder. 20 at the opposite end. Once in position, the convex shape of the pad is flush with the curved shape of the end of the body of the tip.
- the assembly previously formed by the perforated plate for mounting the tubular filters, by the tubular filters and by the guide sleeve, is then forced into the endpiece until the plate comes into contact with the buffer.
- the packaging bottle is then mounted by pressing the dispensing head into the neck of the bottle, after the reservoir of the bottle has been filled with liquid.
- the dispensing head is mounted by first inserting the sleeve in the bottle and this until the end of the collar of the tip against the upper end of the neck of the bottle.
- the dispensing head is then irreversibly snapped into the neck of the bottle by the cooperation of snap-fastening means at right angles which project from the circular wall of the nozzle and which cooperate with grooves of corresponding shapes formed in the inner wall of the neck of the bottle.
- the mounting of the dispensing head as just described has a double advantage in that on the one hand the elements are mounted in a simple manner, mainly by fitting, and in that on the other hand there is no risk of damaging the longitudinal membrane tubes at the time of insertion since they are protected by the sheath that surrounds them.
- the user returns the bottle and positions it above his eyes, and he exerts on the tank wall a manual pressure so as to deform the elastically reversible wall by compressing the interior space.
- the liquid present in the reservoir is pressed against the membrane wall of the tubular filters, whether it is hydrophilic or hydrophobic, but only the hydrophilic membrane surfaces deliver a passage to the liquid which impregnates them due to the differential pressure on either side. membrane, closing at the same time any possibility of air penetration.
- the liquid found inside the hydrophilic wall-type tubular filter is then led to the distribution pad through the perforated plate closing the internal space of the annular tip.
- the pressure to be exerted on the walls of the flask to expel the liquid is less strong than it should be in the bottles of the prior art since the exchange surface proposed by the longitudinal arrangement of the membranes is greater than previously not in the case of a transverse membrane. It also ensures a sufficient liquid output flow through the diameter of the tubes and the number of these tubes defining a hydrophilic passage zone substantially in the center of the plate disposed transversely to the air passage and liquid. The liquid passes beyond the plate and passes through the terminal buffer which provides a splitter effect for the formation of a drop.
- the user releases the pressure on the wall of the bottle and returns it to return it to the rest position. While the wall of the flask resumes its initial cylindrical shape, the liquid is sucked back into the flask by releasing the hydrophobic membrane and the air can freely penetrate therethrough into the flask until pressure equilibrium between the two faces of the flask is reached. filter device. All the time of this operation, the hydrophilic membrane remains impregnated with liquid and impervious to air, while the terminal buffer dries without difficulty.
- the hydrophobic surfaces are arranged close to the through plate at the top of the bottle. at rest, while the hydrophilic surfaces extend longitudinally deeper into the liquid reservoir than the hydrophobic surfaces.
- the longitudinal component of the hydrophilic surfaces which dive deep into the tank, ensures a larger exchange surface to facilitate a larger volume of liquid leaving the tank, so that the pressure at exerting to expel a given volume of liquid can be reduced if the number of tubular filters and the diameter of their internal ducts to ensure the output flow of the liquid.
- the small amount of lost liquid that stagnates against the plate and is not drained by the hydrophilic filters is used to soak the hydrophobic filters to prevent the release of air and allow the proper operation of the bottle until the fluid level is insufficient to fully bathe the hydrophobic filters.
- FIG. 3 A second embodiment will now be described, diagrammatically illustrated in FIG. 3.
- the representation of the dispensing head has been voluntarily enlarged to clarify the arrangement of the elements relative to each other, so that the proportion may not be respected, for example between the width of the tubular filters and the thickness of the walls of the bottle or between the height and the width of the tip.
- the tubular filters hydrophobic membrane 1 32 selectively permeable to air, here have a U-shaped folded like hydrophilic membrane tubular filters 130 dedicated to the liquid outlet. They are of similar diameter, of the order of a millimeter, but of much lesser length. In this way, the hydrophobic functional membrane surface is as previously grouped near the mounting plate of the filtering device, at the top of the bottle.
- the second embodiment also differs in that the sleeve surrounding the tubes or its equivalent do not have a constant diameter.
- a proximal portion 142 is at the tip 1 16 and a distal portion 144 is in the bottle.
- the proximal portion is smaller in diameter and completely fills the inside diameter of the tip, while the distal portion is larger in diameter to reach the the wall of the neck of the bottle 1 10 before diving into the liquid reservoir.
- the second embodiment also differs from the first in that the splitter buffer opens on an outlet channel 146 formed by the tip 1 16 which aims to facilitate the formation and good calibration of a drop.
- the tip in a flexible material that deforms elastically to let the drop around the liquid distribution pad and drain on the channel 146.
- the removable cap January 12 has a shape adapted to close in its screwed position the end of the outlet channel.
- the cap is formed of a hollow cylinder closed at . one end and comp'ortant inside the cylinder a central pin 148 projecting from the radial end wall.
- the cap further comprises two concentric funnels 11 and 150 between the central pin and the peripheral side wall.
- the central pin is intended to cooperate with the outlet channel of the nozzle to close it while the chimneys are intended to bear against the outer surfaces of the nozzle, one bearing radially on the periphery of the body, the other coming in axial support on the collar.
- tubular filters permselective membrane that provide a large exchange surface for the liquid and air to pass through the interface between the liquid reservoir bottle and the outside air. It also allows a simplified embodiment of two distinctly hydrophilic and hydrophobic zones to ensure the alternation of the passage of air and liquid which allows the proper operation of the bottle. It is found that one can thus increase the range of use of the dispensing head according to the invention by diversifying the type of more or less viscous liquid that can be inserted into the bottle associated with this dispensing head. On the one hand, having a larger exchange surface makes it possible to operate the assembly, for the same given liquid to be expelled, by reducing the force exerted to compress the wall of the tank.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
FR1202192A FR2994162B1 (fr) | 2012-08-06 | 2012-08-06 | Tete de distribution de liquide, notamment pour flacon de conditionnement d'un liquide a distribuer goutte a goutte |
PCT/IB2013/001728 WO2014024029A1 (fr) | 2012-08-06 | 2013-08-06 | Tete de distribution de liquide, notamment pour flacon de conditionnement d'un liquide a distribuer goutte a goutte |
Publications (2)
Publication Number | Publication Date |
---|---|
EP2879966A1 true EP2879966A1 (de) | 2015-06-10 |
EP2879966B1 EP2879966B1 (de) | 2018-02-21 |
Family
ID=48520992
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
EP13773332.5A Active EP2879966B1 (de) | 2012-08-06 | 2013-08-06 | Tropfenspenderausgabekopf |
Country Status (24)
Country | Link |
---|---|
US (1) | US9487339B2 (de) |
EP (1) | EP2879966B1 (de) |
JP (1) | JP6250049B2 (de) |
KR (1) | KR102126807B1 (de) |
CN (1) | CN104684815B (de) |
AR (1) | AR092864A1 (de) |
AU (1) | AU2013301315B2 (de) |
BR (1) | BR112015002196B8 (de) |
CA (1) | CA2880175C (de) |
CL (1) | CL2015000175A1 (de) |
CO (1) | CO7220325A2 (de) |
EA (1) | EA028504B1 (de) |
ES (1) | ES2670051T3 (de) |
FR (1) | FR2994162B1 (de) |
HK (1) | HK1210449A1 (de) |
IL (1) | IL237022B (de) |
MA (1) | MA37843B1 (de) |
MX (1) | MX354026B (de) |
MY (1) | MY168490A (de) |
SG (1) | SG11201500894YA (de) |
TN (1) | TN2015000035A1 (de) |
TW (1) | TWI584803B (de) |
UA (1) | UA114206C2 (de) |
WO (1) | WO2014024029A1 (de) |
Families Citing this family (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2016187230A1 (en) * | 2015-05-18 | 2016-11-24 | Cascade Designs, Inc. | Water-treating bottle |
GB2576980B (en) | 2016-01-22 | 2022-10-26 | Baxter Int | Method and machine for producing sterile solution product bags |
NZ743293A (en) | 2016-01-22 | 2019-05-31 | Baxter Healthcare Sa | Sterile solutions product bag |
CN106389002B (zh) * | 2016-09-28 | 2019-08-30 | 尹振图 | 一种滴液瓶嘴及眼药水瓶 |
KR101806524B1 (ko) * | 2016-10-31 | 2017-12-07 | (주)아모레퍼시픽 | 화장품 용기 |
JP6976469B1 (ja) * | 2021-04-26 | 2021-12-08 | さち子 松山 | 目薬容器 |
Citations (2)
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EP0617951A2 (de) * | 1993-03-31 | 1994-10-05 | Tomey Technology Corporation | Tragbare Vorrichtung zum Reinigen von Flüssigkeiten |
WO2011095877A1 (fr) * | 2010-02-04 | 2011-08-11 | Laboratoires Thea | Flacon de conditionnement d'un liquide à tête de distribution goutte a goutte |
Family Cites Families (9)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPS62127063A (ja) * | 1985-11-27 | 1987-06-09 | ト−メ−産業株式会社 | 点眼容器 |
US5105993A (en) * | 1989-12-29 | 1992-04-21 | La Haye Laboratories, Inc. | Disposable medical dispenser with a filtering dispenser nozzle |
FR2770495B1 (fr) * | 1997-11-04 | 1999-12-24 | Transphyto Sa | Dispositif de conditionnement pour liquide a distribuer goutte a goutte |
WO2003014025A1 (en) * | 2001-08-10 | 2003-02-20 | Innova Pure Water Inc. | Hollow fiber membrane filters in various containers |
US20040074529A1 (en) * | 2002-10-21 | 2004-04-22 | Robert Levy | Self-contained and ventilated temporary shelter |
FR2872137B1 (fr) * | 2004-06-24 | 2009-01-23 | Thea Sa Lab | Recipient pour le conditionnement d'un liquide a distributeur goutte a goutte, a deformation reversible par admission d'air |
WO2008097744A1 (en) * | 2007-01-25 | 2008-08-14 | 350 Cambridge Partners, Llc | Water filter device for use with individual containers |
FR2963326B1 (fr) * | 2010-07-30 | 2012-09-07 | Rexam Healthcare La Verpillier | Embout et recipient de distribution de liquide |
TW201225948A (en) * | 2010-12-22 | 2012-07-01 | Rexam Healthcare La Verpillier | A liquid dispenser device |
-
2012
- 2012-08-06 FR FR1202192A patent/FR2994162B1/fr active Active
-
2013
- 2013-08-02 AR ARP130102751A patent/AR092864A1/es active IP Right Grant
- 2013-08-06 MA MA37843A patent/MA37843B1/fr unknown
- 2013-08-06 CA CA2880175A patent/CA2880175C/fr active Active
- 2013-08-06 ES ES13773332.5T patent/ES2670051T3/es active Active
- 2013-08-06 SG SG11201500894YA patent/SG11201500894YA/en unknown
- 2013-08-06 JP JP2015525953A patent/JP6250049B2/ja active Active
- 2013-08-06 MX MX2015001668A patent/MX354026B/es active IP Right Grant
- 2013-08-06 KR KR1020157006016A patent/KR102126807B1/ko active IP Right Grant
- 2013-08-06 BR BR112015002196A patent/BR112015002196B8/pt active Search and Examination
- 2013-08-06 EA EA201590334A patent/EA028504B1/ru not_active IP Right Cessation
- 2013-08-06 MY MYPI2015700378A patent/MY168490A/en unknown
- 2013-08-06 CN CN201380042150.2A patent/CN104684815B/zh active Active
- 2013-08-06 US US14/420,191 patent/US9487339B2/en active Active
- 2013-08-06 TW TW102128061A patent/TWI584803B/zh not_active IP Right Cessation
- 2013-08-06 UA UAA201501991A patent/UA114206C2/uk unknown
- 2013-08-06 EP EP13773332.5A patent/EP2879966B1/de active Active
- 2013-08-06 AU AU2013301315A patent/AU2013301315B2/en not_active Ceased
- 2013-08-06 WO PCT/IB2013/001728 patent/WO2014024029A1/fr active Application Filing
-
2015
- 2015-01-23 CL CL2015000175A patent/CL2015000175A1/es unknown
- 2015-01-23 TN TNP2015000035A patent/TN2015000035A1/fr unknown
- 2015-02-01 IL IL237022A patent/IL237022B/en active IP Right Grant
- 2015-03-06 CO CO15052232A patent/CO7220325A2/es unknown
- 2015-11-11 HK HK15111130.1A patent/HK1210449A1/zh not_active IP Right Cessation
Patent Citations (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP0617951A2 (de) * | 1993-03-31 | 1994-10-05 | Tomey Technology Corporation | Tragbare Vorrichtung zum Reinigen von Flüssigkeiten |
WO2011095877A1 (fr) * | 2010-02-04 | 2011-08-11 | Laboratoires Thea | Flacon de conditionnement d'un liquide à tête de distribution goutte a goutte |
Non-Patent Citations (1)
Title |
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See also references of WO2014024029A1 * |
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