Classifications

• • A—HUMAN NECESSITIES
  • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
  • A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
  • A01N43/00—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds
  • A01N43/90—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having two or more relevant hetero rings, condensed among themselves or with a common carbocyclic ring system
• • A—HUMAN NECESSITIES
  • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
  • A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
  • A01N43/00—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds
  • A01N43/72—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having rings with nitrogen atoms and oxygen or sulfur atoms as ring hetero atoms
  • A01N43/80—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having rings with nitrogen atoms and oxygen or sulfur atoms as ring hetero atoms five-membered rings with one nitrogen atom and either one oxygen atom or one sulfur atom in positions 1,2

Definitions

• compositions Containing Isosorbide Monoesters and Isothiazolinones Description The present invention relates to compositions comprising
• Isosorbide monoester and one or more substances selected from the group consisting of isothiazolinones.
• These compositions can be, for example, cosmetic, dermatological or pharmaceutical compositions or also compositions which are only used for the production of e.g. As cosmetic, dermatological or pharmaceutical compositions can be used. Furthermore, it can also be crop protection formulations, detergents or cleaners or colorants or paints.
• the present invention also relates to
• Isothiazolinones for preserving cosmetic, dermatological or pharmaceutical compositions, crop protection formulations, detergents and cleaning agents or dyes or paints.
• preservatives or biocides are used to preserve cosmetic, dermatological or pharmaceutical compositions, crop protection formulations, detergents and cleaning agents or dyes or paints.
• preservatives or biocides are used to preserve cosmetic, dermatological or pharmaceutical compositions, crop protection formulations, detergents and cleaning agents or dyes or paints.
• preservatives or biocides are used to
• Products such as cosmetic, dermatological or pharmaceutical compositions, crop protection formulations, detergents and
• compositions that have an advantageous preservative performance or have an advantageous stability against microbial infestation and also have the advantage that they are based at least partially on renewable raw materials.
• R is a linear or branched, saturated alkyl group having 5 to 11, preferably 7 to 9 and particularly preferably 7 carbon atoms or a linear or branched, mono- or polyunsaturated
• the invention thus relates to compositions containing
• R is a linear or branched, saturated alkyl group having 5 to 11, preferably 7 to 9 and particularly preferably 7 carbon atoms or a linear or branched, mono- or polyunsaturated
• compositions of the invention have a very good
• Preservative performance or have very good stability against microbial attack, in particular against fungi, and are also based on the presence of the compounds of formula (I) on renewable resources. Since the compounds of formula (I) increase the preservative effect of substances selected from the group consisting of isothiazolinones in some cases even synergistically, especially against fungi, the compounds of formula (I) increase the preservative effect of substances selected from the group consisting of isothiazolinones in some cases even synergistically, especially against fungi, the
• Isothiazolinone significantly reduced to obtain an excellent antimicrobial effect of the compositions of the invention or excellent stability of the compositions according to the invention against microbial attack, especially against fungi.
• compositions according to the invention Compared with the use of organic acids as preservatives, the compositions according to the invention also have the advantage of efficacy or stability against microbial attack, in particular against fungi, over a broader pH range. While organic acids often show a good effect only in the pH range of 3.5 to 6, the compositions of the invention can be used advantageously even at higher pH.
• Compositions for example cosmetic, dermatological or pharmaceutical compositions containing esters based on
• WO 2010/108738 A2 (Evonik) describes formulations for cleaning and care of human or animal body parts containing
• Sorbitan carboxylic acid ester is derived from a carboxylic acid containing 6 to 10 carbon atoms and the sorbitan carboxylic acid esters have a hydroxyl value
• Isothiazolinone in particular methylisothiazolinone, methylchloroisothiazolinone or benzisothiazolinone, as well as their use for preserving
• JP 8173787 (A) (Lion) describes a composition containing a surfactant containing a fatty acid ester of dehydrated sorbitol and the use as an oil-in-water emulsifier and as
• compositions may be mono- or diesters of Caprylic and / or capric with a polyol selected from the group consisting of 1, 5-sorbitan, 1, 4-sorbitan and isosorbide included.
• JP 8187070 (A) (Lion) discloses a mixture of fatty acid monoesters of C 8 -C 18 fatty acids and at least one polyol selected from sorbitol,
• compositions are commercially available or can be prepared by methods familiar to those skilled in the art.
• the compounds of the formula (I) can be prepared by esterification of isosorbide by customary methods known to the person skilled in the art, where both isosorbide itself and the acid components used for the esterification are in turn commercially available.
• the radical R in the one or more compounds of formula (I) is a linear saturated alkyl radical of 7 to 9 carbon atoms.
• the radical R in the one or more compounds of the formula (I) is particularly preferably a linear saturated alkyl radical having 7 carbon atoms.
• the one or more substances of component b) are selected from compounds of the formula (II)
• H or is a branched or unbranched, preferably unbranched, C1-C10 alkyl radical
• unsubstituted or halogen-substituted phenyl ring can form.
• R 1 in formula (II) is preferably H, methyl or n-octyl, more preferably H or methyl, and most preferably methyl.
• R 2 and R 3 in formula (II) are each independently preferably H or Cl, or together with the double bond (of the isothiazolinone ring) to which they are bonded form an unsubstituted phenyl ring.
• the one or more substances is the
• Component b) selected from the group consisting of
• radical R is in the one or more
• Carbon atoms and the compound of component b) is methylisothiazolinone.
• compositions according to the invention contain
• Isosorbide diester is preferably isosorbide dicaprylate
• compositions according to the invention contain either no carboxylic acid RCOOH or up to 0.1, preferably 0.001 to 0.05 and more preferably 0.002 to 0.01 parts by weight of carboxylic acid RCOOH, where R is the formula (I) Has meaning, and wherein the carboxylic acid is preferably
• Capric acid is, based on 1, 0 parts by weight of the one or more Compounds of the formula (I) and preferably based on 1.0 part by weight of isosorbide monocaprylate.
• compositions according to the invention additionally contain one or more
• Sorbitan esters of sorbitan and carboxylic acids R a COOH preferably
• sorbitan esters of 1, 4- and / or 1, 5-sorbitan and carboxylic acids R a COOH wherein R a is a linear or branched, saturated alkyl group having 5 to 11, preferably 7 to 9 and particularly preferably 7 carbon atoms or a linear or branched, mono- or polyunsaturated alkenyl group having 5 to 11, preferably 7 to 9 and particularly preferably 7 carbon atoms, and wherein the weight ratio of the one or more compounds of formula (I) to the one or more of the above-mentioned sorbitan esters of 70 : 30 to 100: 0, preferably from 80: 20 to 100: 0, more preferably from 90: 10 to 100: 0, and most preferably from 95: 5 to 100: 0.
• the indicated weight ratio of "100: 0" means that the
• compositions according to the invention need not contain sorbitan esters in this preferred embodiment of the invention.
• preferred are those wherein the one or more sorbitan esters of sorbitan and carboxylic acids R a COOH are selected from sorbitan esters of sorbitan and caprylic acid, and are preferably selected from sorbitan esters
• the OH number of the mixture of the one or more compounds of formula (I) and the one or more (optionally contained) sorbitan esters of sorbitan and carboxylic acids R a COOH is preferably less than or equal to 320, more preferably less than or equal to is 285, more preferably less than or equal to 245, and most preferably less than or equal to 225.
• compositions according to the invention comprise one or more compounds selected from the group consisting of sorbitol, sorbitol esters (sorbitol esters may be mono-, di-, tri -, tetra-, penta- and / or hexaesters act), sorbitan,
• Sorbitan esters may be mono-, di-, tri- and / or tetra-esters
• isosorbide isosorbide diesters
• carboxylic acids may be, for example, 1, 4 or 1,5 sorbitan, both the carboxylic acids themselves and the carboxylic acids which underlie the acid components of said esters correspond to the formula RCOOH, where R is the same as in formula (I) has the meaning indicated and is preferably a linear saturated alkyl radical having 7 carbon atoms, ie the carboxylic acid RCOOH is preferably caprylic acid
• Embodiment of the invention is the OH number of the mixture of the one or more compounds of formula (I) and the one or more
• compositions according to the invention contain no compounds selected from sorbitol and sorbitol esters. In a further preferred embodiment of the invention, the compositions according to the invention contain no compounds selected from sorbitan and sorbitan esters.
• compositions according to the invention containing one or more
• compositions in which the compounds of component a) and the substances of component b) are contained in relatively high amounts it may, for example, to
• compositions for crop protection formulations, laundry or
• compositions or premixes according to the invention comprise one or more compounds selected from sorbitol and sorbitol esters (the carboxylic acid on which the acid component of these esters is preferably caprylic acid), these compounds are preferably together in an amount of less than or equal to 5.0% by weight. %, more preferably in an amount less than or equal to 3.0 wt .-%, particularly preferably in an amount less than or equal to 1, 0 wt .-% and most preferably in an amount less than or equal to 0.5 wt .-% in the invention
• compositions or premixes according to the invention comprise one or more compounds selected from sorbitan and sorbitan esters (the carboxylic acid on which the acid component of these esters is preferably caprylic acid), these compounds are preferably together in an amount of less than or equal to 20.0 parts by weight. %, more preferably in an amount less than or equal to 10.0 wt .-%, particularly preferably in an amount less than or equal to 5.0 wt .-% and extraordinarily preferably in an amount less than or equal to 1, 0 wt .-% in the
• compositions according to the invention the data in% by weight in each case based on the total weight of the finished inventive
• composition or premix are related.
• compositions or premixes according to the invention in addition to the compounds of component a) and the substances of component b) one or more alcohols, these preferably being selected from the group consisting of propylene glycol, phenoxyethanol and benzyl alcohol, and are at room temperature (25 ° C) liquid.
• one or more alcohols these preferably being selected from the group consisting of propylene glycol, phenoxyethanol and benzyl alcohol, and are at room temperature (25 ° C) liquid.
• Embodiment of the invention is the alcohol propylene glycol, in another preferred embodiment of the invention below is the alcohol
• Phenoxyethanol and in another preferred embodiment of the invention below, the alcohol is benzyl alcohol.
• compositions or premixes according to the invention consist of the
• Carboxylic acids may contain RCOOH. In this preferred embodiment of the invention, these compositions or
• Premixes are solid at room temperature (25 ° C) and preferably they are solid at room temperature (25 ° C). Preferably, these contain
• Weight ratio of ethanol: water 1: 1 is preferably 2 to 9, more preferably 4 to 8 and particularly preferably 5.5 to 7.5.
• compositions or premixtures according to the invention is that they in addition to the very good
• preservative effect also show a beneficial effect as a thickener.
• the hydroxyl or OH number of a substance is understood to mean the amount of KOH in mg which is equivalent to the amount of acetic acid bound in the acetylation of 1 g of substance. Suitable determination methods for determining the OH number are z.
• the OH numbers are determined on the basis of DIN 53240-2. The procedure is as follows: 1 g is weighed to the nearest 0.1 mg from the homogenized sample to be measured. 20.00 ml acetylation mixture (acetylation mixture: in 1 l of pyridine 50 ml
• the OH number (OH) is calculated according to the following formula:
• OHN hydroxyl number in mg KOH / g substance
• Va consumption of caustic soda in ml in the titration of the sample
• Vb consumption of caustic soda in ml in the titration of the effective value
• c molar concentration of the caustic soda in mol / l
• Vb - Va is the amount of sodium hydroxide solution used in ml, which is equivalent to the amount of acetic acid bound in the above-described acetylation of the sample to be measured.
• compositions of the invention cosmetic, dermatological or pharmaceutical compositions, crop protection formulations, detergents and cleaning agents or dyes and paints.
• compositions according to the invention are cosmetic, dermatological or pharmaceutical compositions according to the invention, crop protection formulations, washing and
• Detergents or dyes and paints can from the premixes according to the invention are prepared. Alternatively, they may also be by separate use of the one or more
• compositions according to the invention are cosmetic, dermatological or pharmaceutical compositions. These cosmetic, dermatological or pharmaceutical compositions are described below.
• the cosmetic, dermatological or pharmaceutical compositions according to the invention contain the one or more compounds of component a), preferably in amounts of from 0.01 to 10.0% by weight, more preferably in amounts of from 0.1 to 5.0% by weight. %, more preferably in amounts of 0.2 to 3.0 wt .-% and most preferably in amounts of 0.5 to 2.0 wt .-% and the one or more substances of component b), preferably in amounts of 0.0005 to 0.5% by weight, more preferably 0.001 to 0.5% by weight, more preferably 0.001 to 0.05% by weight, and most preferably 0.01% to 0.05 wt .-%, each based on the total weight of the composition according to the invention.
• the cosmetic, dermatological or pharmaceutical compositions according to the invention contain one or more compounds selected from sorbitol and sorbitol esters (the carboxylic acid on which the acid component of these esters is preferably caprylic acid), these compounds are preferably together in an amount less than or equal to 0.1 Wt .-%, more preferably in an amount less than or equal to 0.06 wt .-%, particularly preferably in an amount less than or equal to 0.02 wt .-% and most preferably in an amount smaller or equal to 0.01 wt .-% in the cosmetic, dermatological or pharmaceutical compositions according to the invention, wherein the data in wt .-% each on the total weight of the finished
• dermatological or pharmaceutical compositions in a further preferred embodiment of the invention no compounds selected from sorbitan and sorbitan esters.
• the cosmetic, dermatological or pharmaceutical compositions according to the invention one or more compounds selected from sorbitan and sorbitan esters (wherein the carboxylic acid underlying the acid component of these esters
• these compounds are together preferably in an amount less than or equal to 0.4 wt .-%, more preferably in an amount less than or equal to 0.2 wt .-%, particularly preferably in an amount less than or equal to 0 , 1 wt .-% and most preferably in an amount less than or equal to 0.02 wt .-% in the cosmetic, dermatological or pharmaceutical compositions according to the invention, wherein the data in wt .-% in each case based on the total weight of the finished composition according to the invention are.
• Cosmetic, dermatological or pharmaceutical compositions according to the invention viscosities preferably in the range of 50 to
• 200,000 mPa ⁇ s preferably in the range from 500 to 100,000 mPa ⁇ s, particularly preferably in the range from 2,000 to 50,000 mPa.s and
• cosmetic, dermatological or pharmaceutical compositions according to the invention in the form of fluids, gels, foams, sprays, lotions or creams.
• the cosmetic, dermatological or pharmaceutical compositions according to the invention are preferably based on aqueous or aqueous-alcoholic bases or are present as solutions, emulsions or dispersions. More preferably, they are in the form of emulsions, and more preferably they are in the form of oil-in-water emulsions.
• the cosmetic, dermatological or pharmaceutical compositions according to the invention are present as oil-in-water emulsions and contain
• compositions preferably, based on the total weight of the compositions, a) up to 95.0% by weight, preferably 49.49 to 95.0% by weight, especially
• isothiazolinones selected from the group consisting of isothiazolinones, the composition containing said compounds and substances in an amount of preferably 30% by weight or more, more preferably 40% by weight or more, and most preferably 50% by weight or more, further wherein the weight ratio compounds of
• Formula (I) Substances selected from the group consisting of isothiazolinones preferably from 98: 2 to 99.995: 0.005 and particularly preferably from 99: 1 to 99.99: 0.01 and wherein it is in the group consisting of isothiazolinones preferably from 98: 2 to 99.995: 0.005 and particularly preferably from 99: 1 to 99.99: 0.01 and wherein it is in the group consisting of isothiazolinones preferably from 98: 2 to 99.995: 0.005 and particularly preferably from 99: 1 to 99.99: 0.01 and wherein it is in the
• composition further preferably to an inventive
• Premix is and d) up to 20.0 wt .-%, preferably 0.5 to 10 wt .-%, particularly preferably 1, 0 to 5.0 wt .-%, particularly preferably 1, 0 to 3.0 wt .-% one or more other additives.
• the one or more other additives in the aforementioned oil-in-water emulsions are selected from the group consisting of emulsifiers, co-emulsifiers, solubilizers, actives, sunscreens, pigments and antimicrobial agents.
• aqueous-alcoholic or alcoholic based pharmaceutical compositions are all monohydric or polyhydric alcohols into consideration.
• alcohols having 1 to 4 carbon atoms such as ethanol, propanol, isopropanol, n-butanol, i-butanol, tert-butanol or glycerol and alkylene glycols, in particular propylene, butylene or hexylene glycol, and
• compositions of the invention may contain one or more oils.
• the oils may advantageously be selected from the groups of triglycerides, natural and synthetic fats, preferably esters of fatty acids with lower C-number alcohols, e.g. Example, with methanol, isopropanol, propylene glycol or glycerol, or esters of fatty alcohols with alkanoic acids of low carbon number or with fatty acids or from the group of alkyl benzoates, and natural or synthetic hydrocarbon oils.
• Triglycerides of linear or branched, saturated or unsaturated, optionally hydroxylated, ce-cao fatty acids, in particular vegetable oils, such as sunflower, maize, soybean, rice, jojoba, babussu, pumpkin, grape seed, are suitable.
• Sesame walnut, apricot, orange, wheat germ, Peach Kernel, Macadamia, avocado, Sweet Almond, Meadowfoam,
• Castor oil olive oil, peanut oil, rapeseed oil and coconut oil, as well as synthetic triglyceride oils, e.g.
• synthetic triglyceride oils e.g.
• the commercial product Myritol ® 318 Also hardened triglycerides come into consideration. It is also possible to use oils of animal origin, for example beef tallow, perhydrosqualene, lanolin.
• Another class of preferred oily substances are the benzoic acid esters of linear or branched Ce- 22 alkanols, z.
• benzoic acid esters of linear or branched Ce- 22 alkanols, z.
• dialkyl ethers having a total of 2 to 36 carbon atoms, especially 12 to
• di-n-octyl ether (Cetiol ® OE), di-n-nonyl ether, di-n-decyl ether, di-n-undecyl ether, di-n-dodecyl ether, n-hexyl-n-octyl ether, n-octyl n -decyl ether, n-decyl-n-undecyl ether, n-undecyl-n-dodecyl ether and n-hexyl-n-undecyl ether, di-3-ethyldecyl ether, tert-butyl-n-octyl ether, iso-pentyl-n-octyl ether and 2-methyl-pentyl-n-octyl ether and di-tert-butyl ether and
• branched saturated or unsaturated fatty alcohols having 6 to 30 carbon atoms for.
• Another class of preferred oil bodies are:
• Hydroxycarboxylic acid alkyl esters Preferred hydroxycarboxylic acid alkyl esters are full esters of glycolic acid, lactic acid, malic acid, tartaric acid or citric acid. Further basically suitable esters of the hydroxycarboxylic acids are esters of ⁇ -hydroxypropionic acid, tartronic acid, D-gluconic acid, sugar acid, mucic acid or glucuronic acid. As the alcohol component of these esters are primary, linear or branched aliphatic alcohols having 8 to 22 carbon atoms. The esters of Ci 2 -cis-fatty alcohols are particularly preferred. Esters of this type are commercially available, e.g. B.
• dicarboxylic acid esters of linear or branched C 2 -Cio-alkanols such as di-n-butyl adipate (Cetiol ® B), di- (2-ethylhexyl) adipate and di- (2-ethylhexyl) succinate and diol esters such as ethylene glycol dioleate, ethylene glycol di-isotridecanoate, propylene glycol di (2-ethylhexanoate), propylene glycol di-isostearate, propylene glycol di-pelargonate, butanediol di-isostearate and neopentyl glycol dicaprylate, and di-isotridecyl acelate.
• dicarboxylic acid esters of linear or branched C 2 -Cio-alkanols such as di-n-butyl adipate (Cetiol ® B), di- (2
• oil bodies are symmetrical, unsymmetrical or cyclic esters of carbonic acid with fatty alcohols, glycerol carbonate or
• Dicaprylyl ether (Cetiol ® CC).
• esters of dimers of unsaturated C 12 -C 22 fatty acids (dimer fatty acids) with monovalent linear, branched or cyclic C 2 -C 6 alkanols or with polyfunctional linear or branched C 2 -C 6 -alkanols.
• hydrocarbon oils for example those with linear or branched, saturated or unsaturated C 7 -C 40 carbon chains, for example Vaseline, dodecane, isododecane, cholesterol, lanolin, synthetic hydrocarbons such as polyolefins, in particular polyisobutene, hydrogenated polyisobutene, polydecane , such as
• Hexadecane, isohexadecane, paraffin oils, isoparaffin oils e.g.
• silicone oils or waxes preferably
• Methyl, and x is a number from 2 to 500, for example those available under the trade names VICASIL (General Electric Company), DOW CORNING 200, DOW CORNING 225, DOW CORNING 200 (Dow Corning Corporation) Dimethicone, as well as the under SilCare Silicone 41 M65, SilCare Silicone 41M70, SilCare ® Silicone 41M80 Dimethicone (Clariant) available,
• compositions according to the invention can be used as further auxiliaries and additives, for example waxes, emulsifiers, co-emulsifiers, solubilizers, electrolytes,
• Hydroxy acids hydroxy acids, stabilizers, cationic polymers, film formers, others
• Thickener Thickener, gelling agent, superfatting agent, moisturizer, other antimicrobial agents, biogenic agents, astringents, deodorants,
• Sunscreens antioxidants, humectants, solvents, colorants, pearlescers, perfumes, opacifiers and / or silicones.
• compositions according to the invention may contain waxes, for example paraffin waxes,
• non-ionic, anionic, cationic or amphoteric surface-active compounds can be used.
• nonionic surface-active compounds are preferably considered:
• ethylene oxide adducts Addition products of 15 to 60 moles of ethylene oxide with castor oil and / or hydrogenated castor oil; Polyol and in particular polyglycerol esters, such as. Polyglycerol polyricinoleate and polyglycerol poly-12-hydroxystearate. Also preferably suitable are ethoxylated fatty amines, fatty acid amides, fatty acid alkanolamides and mixtures of compounds of several of these classes of substances.
• anionic co-emulsifiers such as mono-, di- or tri-phosphoric acid esters, soaps (eg., Sodium stearate),
• Fatty alcohol sulfates but also cationic emulsifiers such as mono-, di- and tri-alkyl quats and their polymeric derivatives.
• amphoteric emulsifiers are preferably available
• Alkylaminoalkylcarboxylic acids betaines, sulfobetaines and imidazoline derivatives.
• fatty alcohol ethoxylates selected from the group of ethoxylated stearyl alcohols, isostearyl alcohols, cetyl alcohols, isocetyl alcohols, oleyl alcohols, lauryl alcohols, isolauryl alcohols and
• Cetylstearyl alcohols in particular polyethylene glycol (13) stearyl ether,
• Polyethylene glycol 1 (15) cetyl ether, polyethylene glycol (16) cetyl ether,
• fatty acid ethoxylates selected from the group of ethoxylated stearates, isostearates and oleates, in particular
• Polyethylene glycol (12) isostearate, polyethylene glycol (13) isostearate,
• Polyethylene glycol (14) isostearate, polyethylene glycol (15) isostearate,
• Polyethylene glycol (20) isostearate, polyethylene glycol (21) isostearate, Polyethylene glycol (22) isostearate, polyethylene glycol (23) isostearate,
• Polyethylene glycol (24) isostearate, polyethylene glycol (25) isostearate,
• the sodium laureth-11-carboxylate can be advantageously used.
• ethoxylated triglycerides polyethylene glycol (60) evening primrose glycerides can be used with advantage.
• polyethylene glycol glycerol fatty acid esters from the group polyethylene glycol (20) glyceryl laurate,
• ethoxylated sorbitan esters are particularly suitable
• Polyethylene glycol (20) sorbitan monooleate Polyethylene glycol (20) sorbitan monooleate.
• Particularly advantageous coemulsifiers are glyceryl monostearate,
• compositions containing one or more substances selected from the group consisting of emulsifiers, co-emulsifiers and solubilizers, this is one or these several substances, based on the total weight of the corresponding inventive composition, preferably in an amount of 0.1 to 20, 0 wt .-%, more preferably in an amount of 0.5 to 10.0 wt .-% and particularly preferably in an amount of 1, 0 to 5.0 wt .-% in the compositions according to the invention.
• the electrolyte can be used inorganic salts, preferably ammonium or metal salts, particularly preferably of halides,
• Metal salts particularly preferably glycolic acid, lactic acid, citric acid, tartaric acid, mandelic acid, salicylic acid, ascorbic acid, pyruvic acid, fumaric acid, retinoic acid, sulfonic acids, benzoic acid, kojic acid, fruit acid, malic acid, gluconic acid or galacturonic acid.
• These include aluminum salts, preferably aluminum chlorohydrate or aluminum-zirconium complex salts.
• cosmetic, dermatological or pharmaceutical compositions according to the invention therefore one or more substances selected from inorganic and organic salts.
• the cosmetic, dermatological or pharmaceutical compositions also mixtures of different salts.
• compositions one or more electrolytes
• compositions are contained, they are, based on the total weight of the corresponding composition according to the invention, preferably in an amount of
• compositions according to the invention 10.0 wt .-% and particularly preferably in an amount of 0.5 to 5.0 wt .-% in the compositions according to the invention.
• the cosmetic, dermatological or pharmaceutical compositions according to the invention contain one or more hydroxy acids, more preferably one or more substances selected from alpha and beta hydroxy acids.
• dermatological or pharmaceutical compositions preferably lactic acid, glycolic acid, salicylic acid and alkylated salicylic acids or
• compositions according to the invention may contain further acidic components.
• the active substance may be tartaric acid,
• Dicarboxylic acids fumaric acid, retinoic acid, sulfonic acids, benzoic acid,
• Dihydroxyacetone or skin-whitening actives such as arbutin or glycyrrhetinic acid and their salts.
• this is one or these several substances, based on the total weight of the corresponding inventive composition, preferably in an amount of 0.1 to 20.0 wt .-%, particularly preferably in an amount of 0.2 to 10.0 wt .-% and particularly preferably in an amount of 0.5 to 5.0 wt .-% in the
• compositions of the invention Contain compositions of the invention.
• the cosmetic, dermatological or pharmaceutical compositions according to the invention therefore comprise one or more substances selected from
• Vitamin C and Vitamin C derivatives wherein the vitamin C derivatives are preferably selected from sodium ascorbyl phosphate, magnesium ascorbyl phosphate and magnesium ascorbyl glucoside.
• the cosmetic, dermatological or pharmaceutical compositions according to the invention contain one or more substances selected from the group consisting of benzoic acid, sorbic acid, salicylic acid, lactic acid and
• Stabilizers can be used in the cosmetic,
• dermatological or pharmaceutical compositions metal salts of fatty acids, such as. As magnesium, aluminum and / or zinc stearate. If the cosmetic, dermatological or pharmaceutical compositions according to the invention comprise one or more of these substances just mentioned, this is one or these several substances.
• Composition according to the invention preferably in an amount of 0.1 to 10.0 wt .-%, particularly preferably in an amount of 0.5 to 8.0 wt .-% and particularly preferably in an amount of 1, 0 to 5, 0 wt .-% in the
• Suitable cationic polymers are the substances known under the INCI name "Polyquaternium", in particular Polyquaternium-31, Polyquaternium-16, Polyquaternium-24, Polyquaternium-7, Polyquaternium-22, Polyquaternium-39, Polyquaternium-28, Polyquaternium-2, Polyquaternium-10, Polyquaternium-1 1, as well as Polyquaternium 37 & mineral oil & PPG trideceth (Salcare SC95), PVP-dimethylaminoethyl methacrylate copolymer, guar hydroxypropyl triammonium chlorides, calcium alginate and ammonium alginate, as well as cationic cellulose derivatives;
• wheat polypeptides ; polyethyleneimines; cationic silicone polymers, such as. B.
• amidomethicones Copolymers of adipic acid and dimethylaminohydroxypropyldiethylenetriamine; Polyaminopolyamide and cationic chitin derivatives such as chitosan.
• compositions containing one or more of the above-mentioned cationic polymers are, based on the total weight of the corresponding inventive composition, preferably in an amount of 0, 1 to 5.0 wt .-%, particularly preferably in an amount of 0.2 to 3.0 wt .-% and particularly preferably in an amount of 0.5 to 2.0 wt .-% in the compositions according to the invention.
• the cosmetic, dermatological or pharmaceutical compositions according to the invention may contain film formers which, depending on the intended use, are selected from salts of
• Phenylbenzimidazole sulfonic acid for example, C 10-polycarbamylpolyglyceryl esters, polyvinyl alcohol,
• Acrylic acid polymers / copolymers or their esters or salts for example Partial ester copolymers of acrylic / methacrylic acid, water-soluble cellulose, for example hydroxymethylcellulose, hydroxyethylcellulose,
• Carboxyvinyl polymers such as carbomers and their salts, polysaccharides, such as polydextrose and glucan, vinyl acetate / crotonate, for example, under the trade name Aristoflex ® A 60 (Clariant) available.
• compositions containing one or more film formers are, based on the total weight of the corresponding inventive composition, preferably in an amount of 0.1 to 10.0 wt .-%, particularly preferably in an amount of 0.2 to 5.0 Wt .-% and particularly preferably in an amount of 0.5 to 3.0 wt .-% in the
• compositions of the invention Contain compositions of the invention.
• compositions can be adjusted by adding further thickeners and gelling agents.
• Cellulose ethers and other cellulose derivatives eg.
• Starch derivatives sodium alginates, fatty acid polyethylene glycol esters, agar agar, caragenan, tragacanth or dextrin derivatives, in particular dextrin esters.
• metal salts of fatty acids preferably 12 to
• Sodium myristate, aluminum monostearate, hydroxy fatty acids for example, 12-hydroxystearic acid, 16-hydroxyhexadecanoic acid; fatty acid amides;
• polyacrylamides or mixtures of such.
• crosslinked and uncrosslinked polyacrylates such as carbomer, sodium polyacrylates or
• sulfonic acid-containing polymers such as ammonium acryloyldimethyltaurate A / P copolymer or sodium acryloyldimethyltaurate A P copolymer. If the cosmetic, dermatological or
• compositions one or more substances selected from the group consisting of the further thickeners and
• Contain gelling agents this is one or these several substances, based on the total weight of the corresponding inventive
• Composition preferably in an amount of 0.01 to 20.0 wt .-%, particularly preferably in an amount of 0.1 to 10.0 wt .-%, particularly preferably in an amount of 0.2 to 3.0 Wt .-% and most preferably in an amount of 0.4 to 2.0 wt .-% in the inventive
• Fatty acid alkanolamides the latter also serving as foam stabilizers. If the cosmetic, dermatological or pharmaceutical compositions according to the invention contain one or more of the substances just mentioned, this is one or these several substances, based on the total weight of the
• composition according to the invention preferably in an amount of 0.01 to 10.0 wt .-%, particularly preferably in an amount of 0.1 to 5.0 wt .-% and particularly preferably in an amount of 0.5 to 3 , 0 wt .-% in the inventive compositions.
• the cosmetic, dermatological or pharmaceutical compositions according to the invention comprise one or more further antimicrobial active ingredients and are preferably in the form of disinfectant compositions and more preferably in the form of disinfectant gels.
• N-lauryl sarcosinate sodium N-palm ethyl sarcosinate, lauroyl sarcosine,
• N-myristoylglycine potassium N-laurylsarcosine, trimethylammonium chloride,
• zinc salts in particular zinc salts, pyrithiones and their heavy metal salts, in particular zinc pyrithione, zinc phenol sulfate, farnesol, ketoconazole, oxiconazole, bifonazoles, butoconazoles, cloconazoles, clotrimazoles, econazoles, enilconazoles,
• Fenticonazole Isoconazole, Miconazole, sulconazole, Tioconazole, fluconazole, itraconazole, Terconazole, naftifine and terbinafine, selenium disulphide and Octopirox® ®, iodopropynylbutylcarbamate, Methyldibromo glutaronitrile, AgCl, Chloroxylenol, sodium salt of diethylhexyl, sodium benzoate, and phenoxyethanol, benzyl alcohol, phenoxy isopropanol, parabens preferred butyl, ethyl, methyl and propylparaben, and their Na salts, pentanediol, 1,2-octanediol, 2-bromo-2-nitropropane-1, 3-diol, ethylhexylglycerol, benzyl alcohol, sorbic acid,
• DDMH Dimethyloldimethylhydantoin
• Na salt of hydroxymethylglycinate Na salt of hydroxymethylglycinate
• hydroxyethylglycine of sorbic acid Na salt of hydroxyethylglycine of sorbic acid and combinations of these active substances are used.
• compositions one or more others
• Containing antimicrobial agents are, based on the total weight of the corresponding inventive composition, preferably in an amount of 0.001 to 5.0 wt .-%, particularly preferably in an amount of 0.01 to 3.0 wt .-% and in particular preferably in an amount of 0.1 to 2.0 wt .-% in the inventive compositions.
• compositions according to the invention may furthermore contain biogenic active substances selected from Plant extracts, such as aloe vera, as well as local anesthetics,
• Antibiotics antiphlogistics, antiallergics, corticosteroids, sebostatics, bisabolol ®, allantoin, phytantriol ®, proteins, vitamins selected from niacin, biotin, vitamin B2, vitamin B3, vitamin B6, vitamin B3 derivatives (salts, acids, esters, amides, alcohols) , Vitamin C and Vitamin C derivatives (salts, acids, esters, amides, alcohols), preferably as the sodium salt of the monophosphoric acid ester of ascorbic acid or as the magnesium salt of the phosphoric acid ester of
• Ascorbic acid Ascorbic acid, tocopherol and tocopherol acetate, and vitamin E and / or its derivatives.
• compositions containing one or more biogenic agents they are, based on the total weight of the corresponding inventive composition, preferably in an amount of
• compositions according to the invention may contain astringents, preferably magnesium oxide,
• compositions according to the invention contain one or more astringents, these are preferably present in an amount of, based on the total weight of the corresponding composition according to the invention
• compositions of the invention 10.0 wt .-% in the compositions of the invention.
• Preferred deodorants are allantoin and bisabolol. If the cosmetic, dermatological or pharmaceutical according to the invention Compositions containing one or more deodorants, these are based on the total weight of the corresponding inventive composition, preferably in an amount of 0.0001 to 10.0 wt .-% in the compositions of the invention.
• the cosmetic, dermatological or pharmaceutical compositions according to the invention contain one or more substances selected from
• inorganic and organic UV filters and more preferably are in the form of sunscreen compositions.
• compositions according to the invention can be used as pigments / micropigments and as well
• inorganic sunscreens or UV filters contain microfine titanium dioxide, mica titanium oxide, iron oxides, mica iron oxide, zinc oxide, silicon oxides, ultramarine blue or chromium oxides.
• the organic sunscreen filters or UV filters are preferably selected from 4-aminobenzoic acid, 3- (4'-trimethylammonium) -benzylideneboran-2-one methylsulfate, Camphor benzalkonium methosulfate, 3,3,5-trimethylcyclohexylsalicylate, 2 Hydroxy-4-methoxybenzophenone, 2-phenylbenzimidazole-5-sulfonic acid and its potassium, sodium and triethanolamine salts, 3,3 ' - (1, 4-phenylenedimethine) bis- (7,7-dimethyl-2-oxobicyclo [ 2.2.1] heptane-1-methanesulfonic acid) and its salts, 1- (4-tert-butylphenyl) -3- (4-methoxyphenyl) propane-1,3-dione, 3- (4 ' sulfo) - benzyliden-bornan-2-one and its salts, 2-cyano-3,3-diphenyl-2
• Salicylate ethyl 2-hexyl 4-dimethyl-aminobenzoate (octyl dimethyl PABA), PEG-25 PABA, 2-hydroxy-4-methoxybenzo-phenone-5-sulfonic acid
• compositions containing one or more sunscreen filters are, based on the total weight of the corresponding inventive composition, preferably in an amount of 0.001 to 30.0 wt .-%, particularly preferably in an amount of 0.05 to
• compositions of the invention 10.0 wt .-% in the compositions of the invention.
• the cosmetic, dermatological or pharmaceutical compositions according to the invention may contain one or more antioxidants, preferably selected from amino acids (eg glycine, histidine, tyrosine, tryptophan) and their derivatives, imidazoles (eg urocanic acid) and their derivatives, peptides such as D, L-carnosine, D-carnosine, L-carnosine and their antioxidants, preferably selected from amino acids (eg glycine, histidine, tyrosine, tryptophan) and their derivatives, imidazoles (eg urocanic acid) and their derivatives, peptides such as D, L-carnosine, D-carnosine, L-carnosine and their
• Derivatives eg anserine
• carotenoids eg ⁇ -carotene, ⁇ -carotene, lycopene
• derivatives thereof chlorogenic acid and its derivatives, lipoic acid and derivatives thereof (eg dihydrolipoic acid), aurothioglucose
• Propylthiouracil and other thiols eg thioredoxin, glutathione, cysteine, cystine, cystamine and their glycosyl, N-acetyl, methyl, ethyl, propyl, amyl, butyl and lauryl
• Homocysteine sulfoximine, buthionine sulfone, penta-, hexa-, heptathionine sulfoximine) in very low tolerated dosages furthermore (metal) chelators (eg.
• ⁇ -hydroxy fatty acids palmitic acid, phytic acid, lactoferrin
• ⁇ -hydroxy acids eg citric acid, lactic acid, malic acid
• humic acid bile acid
• Bile extracts bilirubin, biliverdin, EDTA, EGTA and their derivatives
• unsaturated fatty acids and their derivatives eg ⁇ -linolenic acid, linoleic acid, oleic acid
• folic acid and its derivatives ubiquinone and ubiquinol and derivatives thereof, vitamin C and derivatives (eg B.
• Ascorbyl palmitate Mg ascorbyl phosphate, ascorbyl acetate), tocopherols and derivatives (eg., Vitamin E acetate), Vitamin A and derivatives (Vitamin A palmitate) and Koniferylbenzoat of Benzoeharzes, rutinic acid and derivatives thereof, ⁇ -glycosyl rutin , Ferulic acid, furfurylideneglucitol, carnosine, butylhydroxytoluene, butylhydroxyanisole, nordihydroguaiacetic acid, nordihydroguiaretic acid, trihydroxybutyrophenone, uric acid and theirs
• Nucleotides, nucleosides, peptides and lipids) of said substances are provided.
• antioxidants can protect the skin and hair from oxidative stress.
• Preferred antioxidants are vitamin E and its derivatives as well as vitamin A and its derivatives. If the cosmetic, dermatological or
• compositions containing one or more antioxidants they are, based on the total weight of the corresponding inventive composition, preferably in an amount of
• compositions of the invention 10.0 wt .-% in the compositions of the invention.
• humectants selected from the sodium salt of 2-pyrrolidone-5-carboxylate (NaPCA), guanidine; Glycolic acid and its salts, lactic acid and its salts, glucosamines and their salts,
• Containing humectants are, based on the total weight of the corresponding inventive composition, preferably in an amount of 0.1 to 15.0 wt .-% and particularly preferably in an amount of 0.5 to 5.0 wt .-% in contain the compositions of the invention.
• the cosmetic, dermatological or pharmaceutical compositions of the invention may contain organic solvents.
• organic solvents In principle, all mono- or polyhydric alcohols are suitable as organic solvents. Alcohols having 1 to 4 carbon atoms, such as ethanol, propanol, isopropanol, n-butanol, isobutanol, tert-butanol, glycerol and mixtures of the alcohols mentioned are preferably used. Further preferred alcohols are polyethylene glycols having a molecular weight below 2000. In particular, a use of polyethylene glycol with a relative
• Molecular weight between 200 and 600 and in amounts up to 45.0 wt .-% and of polyethylene glycol having a molecular weight between 400 and 600 in amounts of 5.0 to 25.0 wt .-% is preferred.
• Other suitable solvents include triacetin (glycerol triacetate) and 1-methoxy-2-propanol.
• the cosmetic, dermatological or pharmaceutical compositions of the invention may contain one or more substances selected from colorants, e.g. As dyes and / or pigments.
• colorants e.g. As dyes and / or pigments.
• Dyes and / or pigments according to the invention containing cosmetic, dermatological or pharmaceutical compositions, both organic and inorganic dyes and pigments, are from the corresponding positive list of the Cosmetics Regulation or EC List
• Lycopene 75125 Yellow trans-alpha, beta or gamma-carotene 75130 orange
• Chlorophyll a and b Copper compounds of
• Toner hydrate 77002 White hydrous aluminum silicates 77004 White
• Acid Red 195 Red Also advantageous are oil-soluble natural dyes such. B. paprika extracts, beta-carotene and cochineal.
• Pearlescent pigments eg. As fish silver (guanine / hypoxanthine mixed crystals from fish scales) and mother of pearl (milled
• effect pigments are to be understood as meaning pigments which, by virtue of their refractive properties, cause particular optical effects. Effect pigments lend the treated surface (skin, hair, mucous membrane) gloss or glitter effects or can optically hide skin irregularities and skin wrinkles through diffuse light scattering. As a special
• Particularly suitable effect pigments are, for example, mica particles coated with at least one metal oxide.
• mica particles coated with at least one metal oxide for example, mica particles coated with at least one metal oxide.
• Phyllosilicate, silica gel and other SiO 2 modifications are suitable as a carrier.
• a metal oxide frequently used for coating is, for example, titanium oxide, to which iron oxide may be added, if desired.
• the size and shape (eg spherical, ellipsoidal, flattened, even, uneven) of the pigment particles as well as the thickness of the oxide coating allows the
• Bismuth oxychloride (BiOCl), and the oxides of, for example, titanium, in particular the TiO 2 modifications anatase and rutile, aluminum, tantalum, niobium, zirconium and hafnium. Also with magnesium fluoride (MgF 2 ) and calcium fluoride (fluorspar, CaF 2 ) effect pigments can be produced.
• Particle size distributions range z. From 2 to 50 pm, 5 to 25 pm, 5 to 40 pm, 5 to 60 ⁇ m, 5 to 95 ⁇ m, 5 to 100 ⁇ m, 10 to 60 ⁇ m, 10 to 100 ⁇ m, 10 to 125 ⁇ m,
• Particle size distribution of ⁇ 15 pm provides a uniform silky appearance.
• compositions containing one or more effect pigments are, based on the total weight of the corresponding inventive composition, preferably in an amount of 0.1 to 20.0 wt .-%, particularly preferably in an amount of 0.5 to 10.0 Wt .-% and particularly preferably in an amount of 1, 0 to 5.0 wt .-% in the
• compositions of the invention Contain compositions of the invention.
• pearlescing component are preferably suitable
• Fatty acid monoalkanolamides fatty acid dialkanolamides, monoesters or diesters of alkylene glycols, in particular ethylene glycol and / or propylene glycol or its oligomers, with higher fatty acids, such as. As palmitic acid, stearic acid and behenic acid, monoesters or polyesters of glycerol with carboxylic acids, fatty acids and their metal salts, ketosulfones or mixtures of said compounds.
• ethylene glycol distearates and / or
• Polyethylene glycol distearate with an average of 3 glycol units.
• compositions containing one or more pearlescing compounds are, based on the total weight of the corresponding inventive composition, preferably in an amount of 0.1 to 15.0 wt .-% and particularly preferably in an amount of 1, 0 to 10, 0 wt .-% in the compositions of the invention.
• fragrance or perfume oils can individual fragrance compounds, eg.
• the synthetic products of the ester type ethers, aldehydes, ketones, alcohols and hydrocarbons are used. Fragrance compounds of the ester type are e.g. Benzyl acetate, phenoxyethyl isobutyrate,
• the ethers include, for example, benzyl ethyl ether to the aldehydes z.
• the alcohols include anethole, citronellol, eugenol, geranion, linalol, phenylethyl alcohol and terpineol
• the hydrocarbons include mainly the terpenes and balsams.
• mixtures of different fragrances are used, which together produce an attractive fragrance.
• Perfume oils may also contain natural fragrance mixtures, such as those available from plant or animal sources, e.g. Pine, citrus,
• perfume oils eg. B. sage oil, chamomile oil, clove oil, lemon balm oil, mint oil,
• polymer dispersions in particular polyacrylate derivative, polyacrylamide derivative, poly (acrylate derivative-co-acrylamide derivative) dispersions, poly (styrene derivatives-co-acrylate derivative) dispersions, saturated and unsaturated fatty alcohols can be used.
• silicones the substances mentioned previously under the silicone oils or waxes can be used.
• acids or alkalis for pH adjustment may preferably
• the cosmetic, dermatological or pharmaceutical compositions according to the invention have pH values of preferably 2 to 11, more preferably from 4.5 to 8.5, and most preferably from 5.5 to 8.
• compositions according to the invention are crop protection formulations. These crop protection formulations are described below.
• the crop protection formulations according to the invention contain one or more pesticides.
• the crop protection formulations according to the invention comprise the one or more compounds of component a), preferably in amounts of from 0.01 to 10.0% by weight, particularly preferably in amounts of from 0.1 to 5.0% by weight,
• 0.5 wt .-% particularly preferably in amounts of 0.001 to 0.5 wt .-%, particularly preferably in amounts of 0.001 to 0.05 wt .-% and
• Acid component of this ester underlying carboxylic acid is preferably caprylic acid), these compounds are together preferably in an amount less than or equal to 0.1% by weight, more preferably in an amount less than or equal to 0.06% by weight, particularly preferably in an amount less than or equal to 0.02% by weight and most preferably in an amount less than or equal to 0.01 wt .-% in the inventive
• Crop protection formulations wherein the data in wt .-% are each based on the total weight of the finished composition according to the invention.
• Crop protection formulations in a further preferred embodiment of the invention no compounds selected from sorbitan and sorbitan esters.
• the crop protection formulations according to the invention comprise one or more compounds selected from sorbitan and sorbitan esters (wherein the carboxylic acid underlying the acid component of these esters
• these compounds are together preferably in an amount less than or equal to 0.4 wt .-%, more preferably in an amount less than or equal to 0.2 wt .-%, particularly preferably in an amount less than or equal to 0 , 1 wt .-% and most preferably in an amount less than or equal to 0.02 wt .-% in the inventive
• Crop protection formulations wherein the data in wt .-% are each based on the total weight of the finished composition according to the invention.
• crop protection formulations of the present invention viscosities preferably in the range from 50 to 200,000 mPa ⁇ s, particularly preferably in the range from 500 to 100,000 mPa ⁇ s, particularly preferably in the range of 2 000 to
• the crop protection formulations according to the invention are preferably based on aqueous or aqueous-alcoholic bases or are present as solutions, Emulsions or dispersions. Particularly preferred they are as
• Emulsions before and especially preferred are as oil-in-water
• the crop protection formulations according to the invention have pH values of preferably 2 to 11, more preferably from 4.5 to 8.5, and most preferably from 5.5 to 8.
• compositions according to the invention are detergents or cleaners. These detergents and cleaners are described below.
• the detergents and cleaners according to the invention are preferably liquid detergents and cleaners, such as, for example,
• Hand dishwashing detergents surface cleaners, liquid detergents for textiles, fabric softeners, dishwashing rinse aids and liquid automatic dishwashing detergents.
• washing and cleaning agents according to the invention contain, in addition to water, nonionic, anionic, cationic or amphoteric surfactants
• Suitable nonionic surface-active compounds are preferably:
• Suitable anionic surfactants are linear alkylbenzenesulfonates, alkanesulfonates, alkyl sulfates, ether sulfates and ether carboxylic acids with 1-20 units of ethylene oxide, as well as fatty soaps.
• the cationic compounds used are quaternary ammonium compounds, in particular dimethylalkylamine quat, methyldialkylamine quats and esterquats, in particular triethanolamine ester quats.
• An amphoteric surfactants are preferably available
• Alkylaminoalkylcarboxylic acids dimethylfatty amine oxides, amidoamine oxides, betaines, sulfobetaines and imidazoline derivatives.
• washing and cleaning agents according to the invention can continue
• Solvents and solubilizers such as alcohols, in particular ethanol,
• Detergents come neutralizing agents such as alkali and alkaline earth metal hydroxides, z.
• neutralizing agents such as alkali and alkaline earth metal hydroxides, z.
• alkali and alkaline earth metal hydroxides z.
• Monoethanolamine.triethanolamine or diglycolamine or acidic compounds e.g. As organic acids such as lactic acid, formic acid, acetic acid or
• Citric acid used.
• additives for adjusting the viscosity for.
• thickeners complexing agents against water hardness, inorganic builders such as phosphates, silicates, carbonates or organic builders such as polyacrylates, citrate and phosphonates.
• the detergents of the invention may contain additional additives, such as colorants, soil-release polymers, color transfer inhibitors,
• the detergents and cleaners according to the invention comprise the one or more compounds of component a), preferably in amounts of from 0.01 to 10.0% by weight, particularly preferably in amounts of from 0.1 to 5.0% by weight,
• 0.5 wt .-% particularly preferably in amounts of 0.001 to 0.5 wt .-%, particularly preferably in amounts of 0.001 to 0.05 wt .-% and
• Detergent in a preferred embodiment of the invention no compounds selected from sorbitol and sorbitol esters. Unless the
• Detergents and cleaning agents according to the invention however, one or more compounds selected from sorbitol and sorbitol esters (wherein the
• Acid component of these esters underlying carboxylic acid is preferably caprylic acid), these compounds are together preferably in an amount less than or equal to 0.1 wt .-%, particularly preferably in an amount less than or equal to 0.06 wt .-%, particularly preferably in an amount less than or equal to 0.02 wt .-% and most preferably in an amount less than or equal to 0.01 wt .-% in the inventive washing and
• Contain detergents the data in wt .-% are each based on the total weight of the finished composition according to the invention.
• Detergent in a further preferred embodiment of the invention no compounds selected from sorbitan and sorbitan esters. However, if the washing and cleaning agents according to the invention, one or more compounds selected from sorbitan and sorbitan esters (wherein the
• Acid component of this ester underlying carboxylic acid is preferably caprylic acid
• these compounds are together preferably in an amount less than or equal to 0.4% by weight, more preferably in an amount less than or equal to 0.2% by weight, particularly preferably in an amount less than or equal to 0.1% by weight and most preferably in an amount less than or equal to 0.02 wt .-% in the washing and cleaning agents according to the invention, wherein the data in wt .-% are each based on the total weight of the finished composition according to the invention.
• Inventive detergents and cleaners viscosities preferably in the range of 50 to 200,000 mPa ⁇ s, more preferably in the range of 500 to 100,000 mPa ⁇ s, particularly preferably in the range of 2,000 to
• Detergents and cleaning agents according to the invention in the form of fluids, gels, foams, sprays, lotions or creams.
• the detergents and cleaners according to the invention are preferably based on aqueous or aqueous-alcoholic bases or are present as solutions, emulsions or dispersions. Particularly preferred they are as
• Emulsions before and especially preferred are as oil-in-water
• the detergents and cleaners according to the invention have pH values of preferably 2 to 11, more preferably of 4.5 to 8.5 and particularly preferably of 5.5 to 8.
• the compositions according to the invention are to dye or paint.
• the colorants and paints according to the invention contain one or more pigments which may be inorganic or organic.
• the colorants or paints according to the invention additionally contain one or more substances selected from the group consisting of binders, dispersants and wetting agents, water, fillers, defoamers, thickeners, setting agents and solubilizers.
• Suitable pigments can be found in the table above for the cosmetic, dermatological or pharmaceutical compositions according to the invention.
• the following inorganic pigments are preferably considered: titanium dioxide, zinc sulfides, iron oxides, chromium oxides, cobalt oxides.
• the binders used are preferably emulsion polymers. These usually consist of polymers or copolymers of styrene,
• Acrylic acid esters methacrylic acid esters, acrylic acid, methacrylic acid, vinyl acetate, butadiene, ethylene, vinyl chloride, maleic diesters, vinyl isononanoate and other olefinically unsaturated monomers.
• Further binders are, for example, alkyd resin dispersions, polyurethane and silicone resin dispersions.
• Non-ionic, anionic and cationic surfactants, polyacrylates and their salts, polyurethanes, polyethers and polyamides are preferably available on dispersants and wetting agents.
• the colorants or paints according to the invention comprise one or more nonionic surfactants from the group of alkylphenol polyethylene glycol ethers, styrene-substituted
• Phenol polyethylene glycol ethers alkyl polyethylene glycol ethers, alkylamine ethoxylates, fatty acid polyethylene glycol ethers, alkyl polyalkyl glycol ethers,
• anionic surfactants linear alkylbenzenesulfonates, alkanesulfonates, alkyl sulfates, ether sulfates and ether carboxylic acids with 1-20 units of ethylene oxide can be used.
• quaternary ammonium compounds in particular Dimethylalkylaminquat, Methyldialkylaminquats and Esterquats can be used.
• Suitable fillers are, for example, natural or precipitated calcium carbonate, talc, kaolin, quartz powder or other mineral pigments.
• Suitable defoamers are fatty acid alkyl ester alkoxylates, organopolysiloxanes, silicone oils, paraffin oils or waxes.
• Preferred thickeners are carboxymethylcellulose and
• Hydroxyethyl cellulose Hydroxyethyl cellulose, xanthan gum, or guar guar.
• organic or inorganic bases and acids are used.
• Preferred organic bases are amines such as
• Monoethanolamine, triethanolamine or diisopropylamine preferred
• inorganic bases are alkali and alkaline earth hydroxides, z. Sodium hydroxide, potassium hydroxide or ammonia.
• the colorants or paints according to the invention contain the one or more compounds of component a), preferably in amounts of from 0.01 to 10.0 wt .-%, particularly preferably in amounts of 0.1 to 5.0 wt .-%,
• 0.5 wt .-% particularly preferably in amounts of 0.001 to 0.5 wt .-%, particularly preferably in amounts of 0.001 to 0.05 wt .-% and
• the colorants or paints according to the invention in a preferred embodiment of the invention contain no compounds
• the color or paint compositions according to the invention contain one or more compounds selected from sorbitol and sorbitol esters (the carboxylic acid on which the acid component of these esters is preferably caprylic acid), these compounds are preferably together in an amount of less than or equal to 0.1% by weight. , more preferably in an amount less than or equal to
• the colorants or paints according to the invention in a further preferred embodiment of the invention contain no compounds selected from sorbitan and sorbitan esters.
• the dyestuffs or paints according to the invention contain one or more compounds selected from sorbitan and sorbitan esters (the carboxylic acid on which the acid component of these esters is preferably caprylic acid), these compounds are preferably together in an amount less than or equal to
• compositions are related.
• the composition are related.
• Range of 50 to 200,000 mPa ⁇ s more preferably in the range of 500 to 100,000 mPa ⁇ s, particularly preferably in the range of 2,000 to
• Dyes or paints according to the invention in the form of fluids or sprays are Dyes or paints according to the invention in the form of fluids or sprays.
• the colorants or paints according to the invention are preferably based on aqueous or aqueous-alcoholic bases or are present as solutions, emulsions or dispersions. More preferably, they are in the form of emulsions, and more preferably they are in the form of oil-in-water emulsions.
• the colorants or paints according to the invention have pH values of preferably 2 to 11, more preferably from 4.5 to 8.5, and particularly preferably from 5.5 to 8. Mixtures of one or more compounds of the formula (I) and one or more several substances selected from the group consisting of
• Isothiazolinones or premixes of the invention are advantageously for preserving cosmetic, dermatological or
• Another object of the present invention is therefore the use of one or more compounds of formula (I) and one or more Substances selected from the group consisting of isothiazolinones or premixes according to the invention for preserving cosmetic, dermatological or pharmaceutical compositions,
• Crop protection formulations detergents or cleaning agents or dyes or paints.
• Detergents or dyes or paints are preferably preserved against bacteria and fungi.
• reaction mixture (10 - 12 liters per hour), the reaction mixture is first heated to 180 ° C, wherein the reaction water begins to distill off. The batch is then heated to 190 ° C. in 1 hour and to 210 ° C. in a further 2 hours. After reaching 210 ° C is esterified until an acid number of
• the isosorbide caprylate has the following composition:
• isosorbide caprylate 1 This composition will hereinafter be referred to as "isosorbide caprylate 1".
• composition consisting of 50% by weight of isosorbide caprylate 1 and 50% by weight of a 2% strength by weight solution of methylisothiazolinone in water against bacteria, fungi and yeasts is investigated (the composition is described below)
• composition A For testing with bacteria was
• composition A diluted with butyl polyglycol and then added to liquid, to pH 7 (+/- 0.2) buffered Caso agar (casein peptone agar) at 50 ° C in different concentrations (hereinafter compositions B1, B2, etc. called).
• compositions B1, B2, etc. For testing with mushrooms and with yeasts was Composition A is diluted with butyl polyglycol and then added to liquid Sabouraud 4% dextrose agar buffered to pH 5.6 (+/- 0.2)
• compositions PH1, PH2, etc. given different concentrations (hereinafter compositions PH1, PH2, etc. called). Each of the compositions B1, B2, etc. or PH1, PH2, etc. was poured out into Petri dishes and each inoculated with the same amount of bacteria, fungi and yeasts.
• the minimum inhibitory concentration (MIC) is the concentration at which inhibition of the growth of bacteria, fungi and yeasts occurs in the compositions B1, B2, etc., PH1, PH2, etc.
• the minimum inhibitory concentrations for the pure substances isosorbide caprylate 1 and methylisothiazolinone were determined.
• a is the minimal inhibitory concentration of isosorbide caprylate 1 in the
• QA is the minimum inhibitory concentration of isosorbide caprylate 1,
• Qb is the minimal inhibitory concentration of methylisothiazolinone in the
• QB is the minimal inhibitory concentration of methylisothiazolinone.
• the values for Q a and Q b are calculated from the values for the mixtures ("MIC mixture") by the determined minimum inhibitory concentrations due to the proportions of the ingredients in the investigated inventive composition
• Composition A reproduced.
• composition A Composition A
• Staphylococcus aureus (B) 2500 1250 2000 25 40 1, 25
• Pseudomonas aeruginosa 2000 1000 10000 20 40 0.6
• Escherichia coli 1000 500 2500 10 10 1, 2
• Enterobacter aerogenes (B) 1500 750 10000 15 15 1, 075
• Proteus vulgaris (B) 500 250 2500 5 5 1, 1
• Pseudomonas oleovorans 500 250 10000 5 5 1, 025
• Citrobacter freundii 1000 500 10000 10 15 0.72
• Candida albicans 1000 500 500 10 100 1, 1
• Penicillium funicolosium 750 375 500 7.5 100 0.83 gem .: measured; calculated: calculated; (B): bacterium; (H): yeast; (P): mushroom
• composition according to the invention consisting of 50% by weight
• Caprylic acid has antimicrobial activity. However, since caprylic acid is present in the composition "isosorbide caprylate 1" at only 0.4% by weight, its antimicrobial efficacy in this composition is negligibly small and caprylic acid has no antimicrobial activity at pH values of 6 or greater antimicrobial activity according to example B), the antimicrobial activity of a mixture containing 89.6% by weight of isosorbide dicaprylate and 9.4% by weight was measured in further series of tests.
• Isosorbide monocaprylate (remainder: 1% by weight) (hereinafter referred to as "isosorbide dicaprylate”) on the one hand and pure isosorbide on the other hand The results are shown in Table 2.
• Table 2 Minimum inhibitory concentrations (MIC) of isosorbide dicaprylate and isosorbide
• compositions consisting of
• compositions of Examples a) to d) are carried out by adding the individual components with stirring successively on the finger stirrer
• Formulation example 5 O / W Exfoliating cream with high electrolyte content
• Formulation Example 8 Shampoo / shower bath with suspended particles
• Phase A is mixed, then Phase B and Phase C are added sequentially and the pH is adjusted to 5.5 with Phase E. Finally, phase D is stirred until a homogenous clear gel is formed.
• Phase F is mixed and then added, then phase G is added and stirred until a homogeneous gel is achieved. With phase H, the pH is optionally adjusted to 6.5 and stirred in phase I.
• Formulation Example 12 Elegant OW skincare body lotion with low
• Phase A is melted at 70 ° C, interspersed Phase B and the heated to 70 ° C phase C stirred. After cooling to 35 ° C., phase D is stirred in and the pH is finally adjusted to 6 with phase E.
• Formulation Example 13 Surfactant-free anti-aging O / W gel cream with
• Phase A is melted at 80 ° C, phase B and phase C stirred in succession.
• Phase D is pre-dissolved in Phase E and added.
• Phase F is stirred at 35 ° C and adjusted with phase G, the pH to 6.0. It creates a gel cream.
• Caprylic / Capric Triglycerides 5.0 Cetearyl alcohol 2.0
• Phase A is melted at 80 ° C, phase B and phase C stirred in succession.
• Phase D is pre-dissolved in Phase E and added.
• Phase F is stirred at 35 ° C and adjusted with phase G, the pH to 6.0. It creates a gel cream.
• Phase A is melted at 80 ° C, phase B and phase C stirred in succession.
• Phase D is added at 30 ° C. and phase E is finally stirred in.
• the result is a cream with a pH of 4.2.
• Formulation Examples 16-21 W / O high sunscreen formulations
• Cetearyl Alcohol 1 0 1, 0 1, 0 1, 0 1, 0 1, 0 1, 0
• Aristoflex ® AVC 1, 0 0.6 0.5 0.9 1, 0 1, 0 ad ad ad ad ad ad ad
• the oil-soluble components were heated to 80 ° C,
• Kaliumcetylphosphat and Aristoflex ® AVC sprinkled and the combined water-soluble phases slowly with vigorous stirring in the oil phase entered.
• the emulsions formed were allowed to cool to room temperature with stirring.
• sunscreen filters used in Formulation Examples 16-21, their brand names, and their UV protection range are listed in the following table.
• Neo Heliopan ® 357
• Neo Heliopan ® AP A Tetrasulfonate
• Phenylbenzimidazole sulfonic acid B Formulation example 22 O / W sunscreen cream
• Genagen ® KB (Clariant) 8.0
• Genagen ® CAB (Clariant) 10.0
• the active ingredient is with the other ingredients (except for the Kelzan ® S solution) pre-dispersed, and then subjected to fine grinding until the average particle size is ⁇ 2 microns. Then the Kelzan ® S solution is stirred in.
• Formulation Examples 31-33 Hand dishwashing detergents
• Hydroxethylcellulose 10000 (5a) 2 2 -
• Formulation Examples 40 and 41 are prepared analogously to Formulation Example 39.

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