EP2684561A4 - Composition de type comprimé pour administration orale et procédé pour produire celle-ci - Google Patents

Composition de type comprimé pour administration orale et procédé pour produire celle-ci

Info

Publication number
EP2684561A4
EP2684561A4 EP12754386.6A EP12754386A EP2684561A4 EP 2684561 A4 EP2684561 A4 EP 2684561A4 EP 12754386 A EP12754386 A EP 12754386A EP 2684561 A4 EP2684561 A4 EP 2684561A4
Authority
EP
European Patent Office
Prior art keywords
tablet
oral administration
producing same
type composition
composition
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
EP12754386.6A
Other languages
German (de)
English (en)
Other versions
EP2684561A1 (fr
EP2684561B1 (fr
Inventor
Ayumi Kainose
Yohei KOYA
Yoshiki MACHI
Saichi Ono
Tadahiko Chiba
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Kureha Corp
Original Assignee
Kureha Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Kureha Corp filed Critical Kureha Corp
Publication of EP2684561A1 publication Critical patent/EP2684561A1/fr
Publication of EP2684561A4 publication Critical patent/EP2684561A4/fr
Application granted granted Critical
Publication of EP2684561B1 publication Critical patent/EP2684561B1/fr
Active legal-status Critical Current
Anticipated expiration legal-status Critical

Links

Classifications

    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/20Pills, tablets, discs, rods
    • A61K9/2004Excipients; Inactive ingredients
    • A61K9/2022Organic macromolecular compounds
    • A61K9/205Polysaccharides, e.g. alginate, gums; Cyclodextrin
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/20Pills, tablets, discs, rods
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K33/00Medicinal preparations containing inorganic active ingredients
    • A61K33/44Elemental carbon, e.g. charcoal, carbon black
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/30Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
    • A61K47/32Macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. carbomers, poly(meth)acrylates, or polyvinyl pyrrolidone
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/30Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
    • A61K47/36Polysaccharides; Derivatives thereof, e.g. gums, starch, alginate, dextrin, hyaluronic acid, chitosan, inulin, agar or pectin
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/30Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
    • A61K47/36Polysaccharides; Derivatives thereof, e.g. gums, starch, alginate, dextrin, hyaluronic acid, chitosan, inulin, agar or pectin
    • A61K47/38Cellulose; Derivatives thereof
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/30Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
    • A61K47/42Proteins; Polypeptides; Degradation products thereof; Derivatives thereof, e.g. albumin, gelatin or zein
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/20Pills, tablets, discs, rods
    • A61K9/2095Tabletting processes; Dosage units made by direct compression of powders or specially processed granules, by eliminating solvents, by melt-extrusion, by injection molding, by 3D printing
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/16Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00Drugs for disorders of the urinary system
    • A61P13/12Drugs for disorders of the urinary system of the kidneys
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/18Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P39/00General protective or antinoxious agents

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Epidemiology (AREA)
  • Inorganic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Neurology (AREA)
  • Biomedical Technology (AREA)
  • Neurosurgery (AREA)
  • Urology & Nephrology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Psychiatry (AREA)
  • Toxicology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Medicinal Preparation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
EP12754386.6A 2011-03-04 2012-03-05 Composition de type comprimé pour administration orale et procédé pour produire celle-ci Active EP2684561B1 (fr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP2011047251 2011-03-04
PCT/JP2012/055538 WO2012121202A1 (fr) 2011-03-04 2012-03-05 Composition de type comprimé pour administration orale et procédé pour produire celle-ci

Publications (3)

Publication Number Publication Date
EP2684561A1 EP2684561A1 (fr) 2014-01-15
EP2684561A4 true EP2684561A4 (fr) 2014-08-27
EP2684561B1 EP2684561B1 (fr) 2022-09-14

Family

ID=46798164

Family Applications (1)

Application Number Title Priority Date Filing Date
EP12754386.6A Active EP2684561B1 (fr) 2011-03-04 2012-03-05 Composition de type comprimé pour administration orale et procédé pour produire celle-ci

Country Status (7)

Country Link
US (1) US20130344147A1 (fr)
EP (1) EP2684561B1 (fr)
JP (1) JP5701971B2 (fr)
KR (1) KR101593287B1 (fr)
CN (1) CN103491949B (fr)
TW (1) TWI438011B (fr)
WO (1) WO2012121202A1 (fr)

Families Citing this family (25)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
TW201440819A (zh) * 2013-02-22 2014-11-01 Kureha Corp 經口投予用吸附劑及腎疾病治療劑及肝疾病治療劑
TWI520751B (zh) 2013-02-22 2016-02-11 吳羽股份有限公司 經口投予用吸附劑及腎疾病治療劑及肝疾病治療劑
TWI532508B (zh) * 2013-02-22 2016-05-11 吳羽股份有限公司 經口投予用吸附劑及腎疾病治療劑及肝疾病治療劑
KR101924201B1 (ko) * 2014-02-07 2018-12-03 대원제약주식회사 강도가 증가된 경구 투여형 의약용 흡착제
JP6251667B2 (ja) * 2014-06-03 2017-12-20 アサヒカルピスウェルネス株式会社 錠剤型即放性製剤及びその製造方法
CN108135835A (zh) 2015-08-06 2018-06-08 约翰霍普金斯大学 用于治疗代谢紊乱的组合物和方法
CN108348546A (zh) * 2015-10-26 2018-07-31 第三共株式会社 用于递送至大肠或下部分小肠的多孔材料制剂
ES2767743T3 (es) * 2016-01-22 2020-06-18 Baxter Int Bolsa de producto para soluciones estériles
CN108883129B (zh) * 2016-04-01 2021-01-08 株式会社吴羽 含有口服给药用球状吸附炭的片剂
CN108883130B (zh) * 2016-04-01 2021-06-22 株式会社吴羽 含有口服给药用球状吸附炭的片剂及其制造方法
CN114569633B (zh) * 2017-03-31 2023-11-17 轴向治疗公司 用于治疗和预防孤独症及相关障碍的肠选择性螯合剂
KR102290312B1 (ko) * 2017-04-10 2021-08-17 주식회사 엘지생활건강 정제 조성물 및 이의 제조방법
CN110678170A (zh) 2017-04-14 2020-01-10 比利时胶囊公司 普鲁兰多糖胶囊
CA3059529A1 (fr) 2017-04-14 2018-10-18 Capsugel Belgium Nv Procede de fabrication de pullulane
US11019837B2 (en) 2017-11-08 2021-06-01 Pepsico, Inc. Mouthfeel modulation in reduced and sugar-free beverages using a blend of pectin and xanthan gum
JP7257715B2 (ja) * 2018-06-20 2023-04-14 株式会社東洋新薬 経口組成物
CN110151786B (zh) * 2019-05-06 2021-11-30 天津百纳生物技术有限公司 纳米碳颗粒在制备治疗口腔溃疡的药物中的应用及该药物
CN110959740A (zh) * 2019-12-09 2020-04-07 内蒙古蒙牛乳业(集团)股份有限公司 一种稳定剂组合物、冰淇淋及其制备方法
WO2021134482A1 (fr) * 2019-12-31 2021-07-08 Fresenius Medical Care Deutschland Gmbh Formulation de comprimé de charbon actif comprimé direct
JP7499054B2 (ja) 2020-04-03 2024-06-13 フタムラ化学株式会社 経口投与用錠剤型吸着剤
JP7438897B2 (ja) 2020-08-26 2024-02-27 フタムラ化学株式会社 経口投与用錠剤型吸着剤
CN114762650A (zh) * 2021-01-11 2022-07-19 廊坊新龙立机械制造有限公司 松密度不良的物料加工成预定规格药物的方法
CN114452215B (zh) * 2022-01-07 2024-06-14 西安医学院第二附属医院 一种便于儿童服用的药片制粉冲泡装置
WO2023154547A1 (fr) 2022-02-14 2023-08-17 Axial Therapeutics, Inc. Administration de médicament ciblant le côlon
WO2023154966A1 (fr) * 2022-02-14 2023-08-17 Axial Therapeutics, Inc. Compositions et procédés de séquestration de métabolites dans le tractus gastro-intestinal

Citations (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2787579A (en) * 1952-06-17 1957-04-02 Algemeene Norit Mij Nv Shaped activated carbon medicinal coated with carboxyalkyl ether
US4761284A (en) * 1977-12-27 1988-08-02 Kureha Kagaku Kogy Kabushiki Kaisha Antidote including activated carbon particles
EP0688568A1 (fr) * 1994-05-27 1995-12-27 Kureha Kagaku Kogyo Kabushiki Kaisha Charbon actif sphérique pour le traitement de maladie stoma périphériques inflammatoires
US6294189B1 (en) * 1996-08-07 2001-09-25 De Novo, Inc. Method of forming decontaminant food product
EP1745793A1 (fr) * 2004-04-02 2007-01-24 Kureha Corporation Absorbant pour administration orale, agent thérapeutique ou préventif pour une maladie rénale et agent thérapeutique ou préventif pour une maladie hépatique
WO2009049239A1 (fr) * 2007-10-12 2009-04-16 Ocera Therapeutics, Inc. Utilisation de microsphères de carbone adsorbantes pour traiter la pochite

Family Cites Families (24)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3522708A (en) 1968-04-26 1970-08-04 Geotechnical Drilling Co Ltd T Method of and means for the lowering of ground water
JPS5268275A (en) * 1975-12-04 1977-06-06 Chisso Corp Material used for drainage and its manufacturing process
DE2556561C2 (de) * 1975-12-16 1983-04-14 Boehringer Mannheim Gmbh, 6800 Mannheim Verfahren zur Herstellung von porösen Tabletten
JPS5542210A (en) * 1978-09-12 1980-03-25 Koichi Ogawa Special activated carbon
JPS5595611A (en) * 1979-01-17 1980-07-21 Osamu Otsubo Mannan-coated activated carbon
JPS5673542A (en) 1979-11-22 1981-06-18 Kureha Chem Ind Co Ltd Adsorbent
DE3505433A1 (de) * 1985-02-16 1986-08-21 Basf Ag, 6700 Ludwigshafen Direkttablettierhilfsmittel
JPS6211611A (ja) 1985-07-10 1987-01-20 ロ−ム株式会社 半導体ペレツトの製造方法
JPH11292770A (ja) 1998-04-10 1999-10-26 Kureha Chem Ind Co Ltd マトリックス形成亢進抑制剤
JP2002293907A (ja) 2001-03-28 2002-10-09 Mitsubishi Chemicals Corp ポリエステル樹脂の製造方法
JP2002293906A (ja) 2001-03-28 2002-10-09 Mitsubishi Chemicals Corp ポリエステル樹脂の製造方法
JP3522708B2 (ja) 2001-04-11 2004-04-26 呉羽化学工業株式会社 経口投与用吸着剤
JP2002308786A (ja) * 2001-04-12 2002-10-23 Oto Corporation:Kk 食物繊維で包括されたカーボン粒入りゼリーの製造法
CN1281217C (zh) * 2001-09-13 2006-10-25 陈德才 活性碳在制备治疗甲亢症的口服药物制剂中的应用
ES2285203T3 (es) 2002-11-01 2007-11-16 Kureha Corporation Adsorbentes para administracion oral, curativos o preventivos para enfermedades renales y curativos o preventivos para enfermedades hepaticas.
TWI341732B (en) 2002-11-01 2011-05-11 Kureha Corp Adsorbent for oral administration,agent for treating or preventing renal disease, and
AU2003297260A1 (en) * 2002-11-12 2004-06-03 Elan Pharma International Ltd. Fast-disintegrating solid dosage forms being not friable and comprising pullulan
JP3585043B2 (ja) 2003-01-22 2004-11-04 メルク・ホエイ株式会社 医薬用吸着剤及びその製法
JP2005187405A (ja) 2003-12-25 2005-07-14 Lion Corp 尿酸値抑制剤、及びプリン体吸着剤
TWI370012B (en) 2004-04-02 2012-08-11 Kureha Corp Adsorbent for oral administration, and agent for treating or preventing renal or liver disease
JP4618409B2 (ja) 2004-06-25 2011-01-26 味の素株式会社 経口尿毒症毒素吸着剤
JP4875840B2 (ja) 2004-07-30 2012-02-15 トーアエイヨー株式会社 経口投与用活性炭製剤
JP5124094B2 (ja) 2006-01-24 2013-01-23 マイラン製薬株式会社 医薬用吸着剤
JP5144965B2 (ja) 2007-06-11 2013-02-13 日医工株式会社 医療用吸着剤

Patent Citations (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2787579A (en) * 1952-06-17 1957-04-02 Algemeene Norit Mij Nv Shaped activated carbon medicinal coated with carboxyalkyl ether
US4761284A (en) * 1977-12-27 1988-08-02 Kureha Kagaku Kogy Kabushiki Kaisha Antidote including activated carbon particles
EP0688568A1 (fr) * 1994-05-27 1995-12-27 Kureha Kagaku Kogyo Kabushiki Kaisha Charbon actif sphérique pour le traitement de maladie stoma périphériques inflammatoires
US6294189B1 (en) * 1996-08-07 2001-09-25 De Novo, Inc. Method of forming decontaminant food product
EP1745793A1 (fr) * 2004-04-02 2007-01-24 Kureha Corporation Absorbant pour administration orale, agent thérapeutique ou préventif pour une maladie rénale et agent thérapeutique ou préventif pour une maladie hépatique
WO2009049239A1 (fr) * 2007-10-12 2009-04-16 Ocera Therapeutics, Inc. Utilisation de microsphères de carbone adsorbantes pour traiter la pochite

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
See also references of WO2012121202A1 *

Also Published As

Publication number Publication date
KR101593287B1 (ko) 2016-02-11
EP2684561A1 (fr) 2014-01-15
JP5701971B2 (ja) 2015-04-15
CN103491949A (zh) 2014-01-01
US20130344147A1 (en) 2013-12-26
CN103491949B (zh) 2017-02-08
EP2684561B1 (fr) 2022-09-14
TWI438011B (zh) 2014-05-21
TW201249478A (en) 2012-12-16
WO2012121202A1 (fr) 2012-09-13
KR20130130063A (ko) 2013-11-29
JPWO2012121202A1 (ja) 2014-07-17

Similar Documents

Publication Publication Date Title
EP2684561A4 (fr) Composition de type comprimé pour administration orale et procédé pour produire celle-ci
HRP20190080T1 (hr) Postupak i formulacija za inhaliranje
HK1211915A1 (en) Method for producing dental restorations
IL229382B (en) A method to generate polyploid megakaryocytes and platelets
HK1187805A1 (zh) 牙科鑽頭及其製造方法
EP2763933A4 (fr) Procédés de fabrication de nanoparticules et d'utilisation de celles-ci
EP2679099A4 (fr) Chocolats et leur procédé de fabrication
PL2678035T3 (pl) Pochodne fenalen-1-onu, sposób ich wytwarzania i zastosowanie
GB201009237D0 (en) New administration method
EP2549877A4 (fr) Composition et procédé permettant d'empêcher une affection buccale
SG11201404500SA (en) Dental implant and method for producing same
SG11201400909WA (en) Composition and method for producing same
IL232970A0 (en) Oral spray compounds
EP2695530A4 (fr) Tabac à usage oral et procédé de fabrication de ce dernier
EP2738243A4 (fr) Composition glycéridique purifiée et son procédé de production
EP2786982A4 (fr) Dérivés amino-propylène-glycol, procédé de préparation, composition pharmaceutique et utilisation correspondante
SG10201604976RA (en) Hydroxy-aminopolymers and method for producing same
EP2676975A4 (fr) Composition sans solvant et procédé pour préparer celle-ci
PL2755498T3 (pl) Kompozycja do podawania doustnego zwierzętom i sposób jej wytwarzania
EP2698159A4 (fr) Préparation contenant de la pitavastatine et son procédé de production
IL231505A0 (en) Pharmaceutical preparation and method for its production
EP2668852A4 (fr) Composition pour administration orale
ZA201309559B (en) Comptothecin derivative, method for preparing same, pharmaceutical composition and use thereof
ZA201304127B (en) Oral compositions and method for producing thereof
EP2742946A4 (fr) Procédé pour la production de dérivés de pyrostegia venusta, dérivés de pyrostegia venusta, compositions pharmaceutiques et leurs utilisations

Legal Events

Date Code Title Description
PUAI Public reference made under article 153(3) epc to a published international application that has entered the european phase

Free format text: ORIGINAL CODE: 0009012

17P Request for examination filed

Effective date: 20130923

AK Designated contracting states

Kind code of ref document: A1

Designated state(s): AL AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LI LT LU LV MC MK MT NL NO PL PT RO RS SE SI SK SM TR

DAX Request for extension of the european patent (deleted)
A4 Supplementary search report drawn up and despatched

Effective date: 20140725

RIC1 Information provided on ipc code assigned before grant

Ipc: A61P 13/12 20060101ALI20140721BHEP

Ipc: A61P 1/16 20060101ALI20140721BHEP

Ipc: A61K 47/42 20060101ALI20140721BHEP

Ipc: A61K 9/20 20060101AFI20140721BHEP

Ipc: A61K 47/46 20060101ALI20140721BHEP

Ipc: A61K 47/32 20060101ALI20140721BHEP

Ipc: A61K 33/44 20060101ALI20140721BHEP

Ipc: A61P 25/18 20060101ALI20140721BHEP

Ipc: A61K 47/38 20060101ALI20140721BHEP

Ipc: A61K 47/36 20060101ALI20140721BHEP

17Q First examination report despatched

Effective date: 20160704

STAA Information on the status of an ep patent application or granted ep patent

Free format text: STATUS: EXAMINATION IS IN PROGRESS

STAA Information on the status of an ep patent application or granted ep patent

Free format text: STATUS: EXAMINATION IS IN PROGRESS

STAA Information on the status of an ep patent application or granted ep patent

Free format text: STATUS: EXAMINATION IS IN PROGRESS

REG Reference to a national code

Ref country code: DE

Ref legal event code: R079

Ref document number: 602012078748

Country of ref document: DE

Free format text: PREVIOUS MAIN CLASS: A61K0009200000

Ipc: A61K0033440000

RIC1 Information provided on ipc code assigned before grant

Ipc: A61P 39/00 20060101ALI20220207BHEP

Ipc: A61P 25/18 20060101ALI20220207BHEP

Ipc: A61P 13/12 20060101ALI20220207BHEP

Ipc: A61P 1/16 20060101ALI20220207BHEP

Ipc: A61K 9/20 20060101ALI20220207BHEP

Ipc: A61K 33/44 20060101AFI20220207BHEP

GRAP Despatch of communication of intention to grant a patent

Free format text: ORIGINAL CODE: EPIDOSNIGR1

STAA Information on the status of an ep patent application or granted ep patent

Free format text: STATUS: GRANT OF PATENT IS INTENDED

INTG Intention to grant announced

Effective date: 20220322

GRAS Grant fee paid

Free format text: ORIGINAL CODE: EPIDOSNIGR3

GRAA (expected) grant

Free format text: ORIGINAL CODE: 0009210

STAA Information on the status of an ep patent application or granted ep patent

Free format text: STATUS: THE PATENT HAS BEEN GRANTED

AK Designated contracting states

Kind code of ref document: B1

Designated state(s): AL AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LI LT LU LV MC MK MT NL NO PL PT RO RS SE SI SK SM TR

REG Reference to a national code

Ref country code: GB

Ref legal event code: FG4D

REG Reference to a national code

Ref country code: CH

Ref legal event code: EP

REG Reference to a national code

Ref country code: DE

Ref legal event code: R096

Ref document number: 602012078748

Country of ref document: DE

REG Reference to a national code

Ref country code: IE

Ref legal event code: FG4D

REG Reference to a national code

Ref country code: AT

Ref legal event code: REF

Ref document number: 1518314

Country of ref document: AT

Kind code of ref document: T

Effective date: 20221015

REG Reference to a national code

Ref country code: LT

Ref legal event code: MG9D

REG Reference to a national code

Ref country code: NL

Ref legal event code: MP

Effective date: 20220914

PG25 Lapsed in a contracting state [announced via postgrant information from national office to epo]

Ref country code: SE

Free format text: LAPSE BECAUSE OF FAILURE TO SUBMIT A TRANSLATION OF THE DESCRIPTION OR TO PAY THE FEE WITHIN THE PRESCRIBED TIME-LIMIT

Effective date: 20220914

Ref country code: RS

Free format text: LAPSE BECAUSE OF FAILURE TO SUBMIT A TRANSLATION OF THE DESCRIPTION OR TO PAY THE FEE WITHIN THE PRESCRIBED TIME-LIMIT

Effective date: 20220914

Ref country code: NO

Free format text: LAPSE BECAUSE OF FAILURE TO SUBMIT A TRANSLATION OF THE DESCRIPTION OR TO PAY THE FEE WITHIN THE PRESCRIBED TIME-LIMIT

Effective date: 20221214

Ref country code: LV

Free format text: LAPSE BECAUSE OF FAILURE TO SUBMIT A TRANSLATION OF THE DESCRIPTION OR TO PAY THE FEE WITHIN THE PRESCRIBED TIME-LIMIT

Effective date: 20220914

Ref country code: LT

Free format text: LAPSE BECAUSE OF FAILURE TO SUBMIT A TRANSLATION OF THE DESCRIPTION OR TO PAY THE FEE WITHIN THE PRESCRIBED TIME-LIMIT

Effective date: 20220914

Ref country code: FI

Free format text: LAPSE BECAUSE OF FAILURE TO SUBMIT A TRANSLATION OF THE DESCRIPTION OR TO PAY THE FEE WITHIN THE PRESCRIBED TIME-LIMIT

Effective date: 20220914

REG Reference to a national code

Ref country code: AT

Ref legal event code: MK05

Ref document number: 1518314

Country of ref document: AT

Kind code of ref document: T

Effective date: 20220914

PG25 Lapsed in a contracting state [announced via postgrant information from national office to epo]

Ref country code: HR

Free format text: LAPSE BECAUSE OF FAILURE TO SUBMIT A TRANSLATION OF THE DESCRIPTION OR TO PAY THE FEE WITHIN THE PRESCRIBED TIME-LIMIT

Effective date: 20220914

Ref country code: GR

Free format text: LAPSE BECAUSE OF FAILURE TO SUBMIT A TRANSLATION OF THE DESCRIPTION OR TO PAY THE FEE WITHIN THE PRESCRIBED TIME-LIMIT

Effective date: 20221215

PG25 Lapsed in a contracting state [announced via postgrant information from national office to epo]

Ref country code: SM

Free format text: LAPSE BECAUSE OF FAILURE TO SUBMIT A TRANSLATION OF THE DESCRIPTION OR TO PAY THE FEE WITHIN THE PRESCRIBED TIME-LIMIT

Effective date: 20220914

Ref country code: RO

Free format text: LAPSE BECAUSE OF FAILURE TO SUBMIT A TRANSLATION OF THE DESCRIPTION OR TO PAY THE FEE WITHIN THE PRESCRIBED TIME-LIMIT

Effective date: 20220914

Ref country code: PT

Free format text: LAPSE BECAUSE OF FAILURE TO SUBMIT A TRANSLATION OF THE DESCRIPTION OR TO PAY THE FEE WITHIN THE PRESCRIBED TIME-LIMIT

Effective date: 20230116

Ref country code: ES

Free format text: LAPSE BECAUSE OF FAILURE TO SUBMIT A TRANSLATION OF THE DESCRIPTION OR TO PAY THE FEE WITHIN THE PRESCRIBED TIME-LIMIT

Effective date: 20220914

Ref country code: CZ

Free format text: LAPSE BECAUSE OF FAILURE TO SUBMIT A TRANSLATION OF THE DESCRIPTION OR TO PAY THE FEE WITHIN THE PRESCRIBED TIME-LIMIT

Effective date: 20220914

Ref country code: AT

Free format text: LAPSE BECAUSE OF FAILURE TO SUBMIT A TRANSLATION OF THE DESCRIPTION OR TO PAY THE FEE WITHIN THE PRESCRIBED TIME-LIMIT

Effective date: 20220914

PG25 Lapsed in a contracting state [announced via postgrant information from national office to epo]

Ref country code: SK

Free format text: LAPSE BECAUSE OF FAILURE TO SUBMIT A TRANSLATION OF THE DESCRIPTION OR TO PAY THE FEE WITHIN THE PRESCRIBED TIME-LIMIT

Effective date: 20220914

Ref country code: PL

Free format text: LAPSE BECAUSE OF FAILURE TO SUBMIT A TRANSLATION OF THE DESCRIPTION OR TO PAY THE FEE WITHIN THE PRESCRIBED TIME-LIMIT

Effective date: 20220914

Ref country code: IS

Free format text: LAPSE BECAUSE OF FAILURE TO SUBMIT A TRANSLATION OF THE DESCRIPTION OR TO PAY THE FEE WITHIN THE PRESCRIBED TIME-LIMIT

Effective date: 20230114

Ref country code: EE

Free format text: LAPSE BECAUSE OF FAILURE TO SUBMIT A TRANSLATION OF THE DESCRIPTION OR TO PAY THE FEE WITHIN THE PRESCRIBED TIME-LIMIT

Effective date: 20220914

REG Reference to a national code

Ref country code: DE

Ref legal event code: R097

Ref document number: 602012078748

Country of ref document: DE

P01 Opt-out of the competence of the unified patent court (upc) registered

Effective date: 20230512

PG25 Lapsed in a contracting state [announced via postgrant information from national office to epo]

Ref country code: NL

Free format text: LAPSE BECAUSE OF FAILURE TO SUBMIT A TRANSLATION OF THE DESCRIPTION OR TO PAY THE FEE WITHIN THE PRESCRIBED TIME-LIMIT

Effective date: 20220914

Ref country code: AL

Free format text: LAPSE BECAUSE OF FAILURE TO SUBMIT A TRANSLATION OF THE DESCRIPTION OR TO PAY THE FEE WITHIN THE PRESCRIBED TIME-LIMIT

Effective date: 20220914

PLBE No opposition filed within time limit

Free format text: ORIGINAL CODE: 0009261

STAA Information on the status of an ep patent application or granted ep patent

Free format text: STATUS: NO OPPOSITION FILED WITHIN TIME LIMIT

PG25 Lapsed in a contracting state [announced via postgrant information from national office to epo]

Ref country code: DK

Free format text: LAPSE BECAUSE OF FAILURE TO SUBMIT A TRANSLATION OF THE DESCRIPTION OR TO PAY THE FEE WITHIN THE PRESCRIBED TIME-LIMIT

Effective date: 20220914

26N No opposition filed

Effective date: 20230615

PG25 Lapsed in a contracting state [announced via postgrant information from national office to epo]

Ref country code: SI

Free format text: LAPSE BECAUSE OF FAILURE TO SUBMIT A TRANSLATION OF THE DESCRIPTION OR TO PAY THE FEE WITHIN THE PRESCRIBED TIME-LIMIT

Effective date: 20220914

PG25 Lapsed in a contracting state [announced via postgrant information from national office to epo]

Ref country code: MC

Free format text: LAPSE BECAUSE OF FAILURE TO SUBMIT A TRANSLATION OF THE DESCRIPTION OR TO PAY THE FEE WITHIN THE PRESCRIBED TIME-LIMIT

Effective date: 20220914

REG Reference to a national code

Ref country code: CH

Ref legal event code: PL

REG Reference to a national code

Ref country code: BE

Ref legal event code: MM

Effective date: 20230331

PG25 Lapsed in a contracting state [announced via postgrant information from national office to epo]

Ref country code: LU

Free format text: LAPSE BECAUSE OF NON-PAYMENT OF DUE FEES

Effective date: 20230305

REG Reference to a national code

Ref country code: IE

Ref legal event code: MM4A

PG25 Lapsed in a contracting state [announced via postgrant information from national office to epo]

Ref country code: LI

Free format text: LAPSE BECAUSE OF NON-PAYMENT OF DUE FEES

Effective date: 20230331

Ref country code: IE

Free format text: LAPSE BECAUSE OF NON-PAYMENT OF DUE FEES

Effective date: 20230305

Ref country code: CH

Free format text: LAPSE BECAUSE OF NON-PAYMENT OF DUE FEES

Effective date: 20230331

PG25 Lapsed in a contracting state [announced via postgrant information from national office to epo]

Ref country code: BE

Free format text: LAPSE BECAUSE OF NON-PAYMENT OF DUE FEES

Effective date: 20230331

PGFP Annual fee paid to national office [announced via postgrant information from national office to epo]

Ref country code: DE

Payment date: 20240320

Year of fee payment: 13

Ref country code: GB

Payment date: 20240320

Year of fee payment: 13

PG25 Lapsed in a contracting state [announced via postgrant information from national office to epo]

Ref country code: IT

Free format text: LAPSE BECAUSE OF FAILURE TO SUBMIT A TRANSLATION OF THE DESCRIPTION OR TO PAY THE FEE WITHIN THE PRESCRIBED TIME-LIMIT

Effective date: 20220914

PGFP Annual fee paid to national office [announced via postgrant information from national office to epo]

Ref country code: FR

Payment date: 20240327

Year of fee payment: 13