EP2654705A2 - Active ingredient combinations of glyceryl glucosides and one or more mild surfactants - Google Patents

Active ingredient combinations of glyceryl glucosides and one or more mild surfactants

Info

Publication number
EP2654705A2
EP2654705A2 EP11790950.7A EP11790950A EP2654705A2 EP 2654705 A2 EP2654705 A2 EP 2654705A2 EP 11790950 A EP11790950 A EP 11790950A EP 2654705 A2 EP2654705 A2 EP 2654705A2
Authority
EP
European Patent Office
Prior art keywords
phase
surfactants
preparations
mild
active
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
EP11790950.7A
Other languages
German (de)
French (fr)
Inventor
Rainer Kröpke
Christian Frese
Cathrin Scherner
Henrike Neuhoff
Stefanie Hentrey
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Beiersdorf AG
Original Assignee
Beiersdorf AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Beiersdorf AG filed Critical Beiersdorf AG
Priority to EP18176961.3A priority Critical patent/EP3409266A1/en
Publication of EP2654705A2 publication Critical patent/EP2654705A2/en
Ceased legal-status Critical Current

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q19/00—Preparations for care of the skin
    • A61Q19/10—Washing or bathing preparations
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/60—Sugars; Derivatives thereof
    • A61K8/602—Glycosides, e.g. rutin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/60—Sugars; Derivatives thereof
    • A61K8/604—Alkylpolyglycosides; Derivatives thereof, e.g. esters
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q5/00—Preparations for care of the hair
    • A61Q5/02—Preparations for cleaning the hair

Definitions

  • the present invention relates to active ingredient combinations of glucosylglycerides and one or more mild surfactants and their use in the field of cosmetic and pharmaceutical dermatology.
  • the present invention relates to active ingredients and cosmetic or dermatological preparations containing such drug combinations.
  • the present invention preferably relates to washing-active cosmetic preparations.
  • the outermost layer of the epidermis, the stratum corneum (horny layer), is of particular importance as an important barrier layer, inter alia. for protection against environmental influences and dehydration.
  • the horny layer is constantly worn in contact with the environment and must therefore be renewed continuously.
  • a skin model widely used today in the art understands the stratum corneum as a two-component system, similar to a brick wall (brick-mortar model).
  • the corneocytes horny cells
  • the complex composite lipid membrane in the intercellular spaces corresponds to the mortar.
  • the epidermal lipids In addition to their barrier effect against external chemical and physical influences, the epidermal lipids also contribute to the cohesion of the horny layer and have an influence on the skin smoothness. In contrast to the sebaceous gland lipids, which do not form a closed film on the skin, the epidermal lipids are distributed over the entire horny layer.
  • the extremely complex interaction of the moisture-binding substances and the lipids of the upper skin layers is very important for the regulation of skin moisture. Therefore, cosmetics usually contain, in addition to balanced lipid mixtures and water, water-binding substances. These include polyols such as glycerin, sorbitol and xylitol, ethoxylated polyols and hydrolyzed proteins.
  • Natural Moisturizing Factor NMF
  • urea e.g glucose
  • amino acids e.g serine
  • Cleaning means the removal of (environmental) dirt and thus causes an increase in mental and physical well-being.
  • Cleaning the surface of the skin and hair is a very complex process, depending on many parameters.
  • substances coming from outside such as, for example, hydrocarbons or inorganic pigments from a wide variety of environments as well as residues of cosmetics or undesired microorganisms should be removed as completely as possible.
  • the body's excretions such as sweat, sebum, dandruff and hair dandruff are to be washed off without profound interventions in the physiological balance.
  • Cosmetic cleansing preparations for the skin and hair which are offered, for example, as shampoos, shower baths and liquid soaps, not only have to have a good cleaning power, but should continue to be well-tolerated and have a skin and hair-care effect. Also at one Frequent use should not lead to defatting or dryness of the skin or hair.
  • Cosmetic cleansing preparations which are particularly gentle to the skin and hair usually contain particularly mild surfactants, such as e.g. Sugar surfactants or amino acid surfactants. While these surfactants allow gentle cleansing of the skin and hair, the foaming power of these surfactants is not adequate to meet consumers' requirements for the foam of a cleansing product.
  • the foam should be particularly rich, creamy and rich. Furthermore, the sensory properties of cleansing formulations containing mild surfactants are unsatisfactory.
  • cosmetic cleansing preparations which produce a particularly creamy and rich lather often contain high levels of anionic sulphate surfactant, which is known to be particularly aggressive to the skin and cause dehydration of the skin, often through reddened, cracked and exciting skin revealed.
  • the standard RBC test is used to estimate in vivo ocular irritation potentials of surfactants and surfactant-containing products.
  • the method relies on the fact that surfactants interact strongly with cell membranes and proteins. Both effects are determined photometrically by analysis of the natural blood dye oxyhemoglobin (HbOa).
  • HbOa natural blood dye oxyhemoglobin
  • the RBC test is able to differentiate between damage to the cell membrane (hemolysis) and protein denaturation (denaturation index).
  • PBS is a common standard phosphate buffer (pH 7.4) having the following composition:
  • the incubation period is terminated by rapid high speed centrifugation. After centrifugation, the supernatants obtained are analyzed photometrically for their content of released hemoglobin (HbO 2) at 530 nm. From this, the relative degree of hemolysis is calculated and the concentration-response curve with the H50 value [ ⁇ / ml] is determined as a parameter. This indicates the concentration of the test sample at which 50% of hemoglobin is released. The higher the value, the more compatible the sample studied.
  • Hb0 2 denaturation A defined aliquot of isolated calf RBCs is incubated with a fixed concentration of the test sample (concentration for raw materials 0, 1% by weight active content of the detergent in PBS, concentration for finished products 1% w / v in PBS) for 10 minutes with shaking at RT and then centrifuged. The change in spectral absorption at 575 nm and 540 nm is measured in comparison to the native Hb0 2 . The denaturation index DI [%] is calculated from the ratio of the absorption values to one another. The 100% standard is sodium lauryl sulfate (0, 1% active content).
  • the quotient (L / D value) represents the ratio of the parameters of hemolysis (H50) and denaturation (DI) and is used to characterize and classify the examined test samples.
  • Surfactants or surfactant mixtures are considered to be mild according to the invention if the L / D value is at least 1.
  • the sodium lauryl ether sulfate commonly used in cleaning products has an L / D of about 0.3 and is classified as irritating. If sodium lauryl ether sulfate is used in a surfactant mixture, the resulting surfactant mixture according to the invention has an L / D value of at least 1.
  • Preferred mild surfactants are:
  • Alkyl polyglucosides e.g. Lauryl glucoside, decyl glucoside and
  • Amphoacetates such as e.g. , sodium,
  • Betaine surfactants such as e.g. Cocamidopropyl betaine or cocobetaine,
  • Amino acid surfactants such as e.g. Sodium lauroylglutamate and
  • Ethoxylated glycerides such as e.g. PEG-7 glyceryl cocoate,
  • Taurates such as e.g. sodium methyl,
  • Sarcosinates e.g. sodium lauroyl
  • Sulfosuccinates such as disodium PEG-5 lauryl citrate sulfosuccinate
  • the following table lists preferred mild surfactants with their L / D values:
  • Particularly preferred mild surfactants are alkyl polyglucosides, e.g. Lauryl glucoside and decyl glucoside, betaine surfactants, e.g. Cocamidopropyl betaine or cocobetaine, amino acid surfactants, such as e.g. Sodium lauroyl glutamate and disodium cocoyl glutamate and ethoxylated glycerides such as e.g. PEG-7 glyceryl cocoate.
  • alkyl polyglucosides e.g. Lauryl glucoside and decyl glucoside
  • betaine surfactants e.g. Cocamidopropyl betaine or cocobetaine
  • amino acid surfactants such as e.g. Sodium lauroyl glutamate and disodium cocoyl glutamate and ethoxylated glycerides such as e.g. PEG-7 glyceryl cocoate.
  • Preferred concentration of the mild surfactants is 0.01 to 20%, more preferably 0, 1-15%, most preferably 1% - 10%.
  • glucosylglycerides of the general formula are advantageous
  • those preparations are particularly advantageous, which are characterized in that the glucosylglyceride or in the water and / or oil phase in concentrations of 0.001 to 40.00 wt .-%, preferably 0.005 to 15.00 wt .-%, especially preferably 0.01 to 12.00 wt .-%, each based on the total weight of the composition.
  • the molar ratio of one or more glucosylglycerides to one or more mild surfactants from the range of 100: 1 to 1: 1000, preferably 50: 1 to 1: 500, particularly preferably 20: 1 to 1: 100 to choose.
  • the use of the preparation according to the invention as a cosmetic cleansing preparation is advantageous according to the invention.
  • the preparation according to the invention is preferably used as a shower gel, foam bath and bath, shampoo and / or facial cleanser.
  • the cosmetic preparation according to the invention is stored in a bottle, squeeze bottle, pump spray or aerosol can and applied out of it.
  • bottles, squeeze bottles, double-chamber packing, pump spray or aerosol cans containing a preparation according to the invention are also suitable according to the invention.
  • the preparation according to the invention advantageously contains further surfactants.
  • These are according to the invention advantageously in a concentration of 0, 1 to 5% by weight, and according to the invention preferably in a concentration of 1 to 3% by weight, based in each case on the total weight of the preparation in the preparation.
  • Particularly preferred according to the invention is the use of sodium lauryl ether sulfate or sodium myristyl ether sulfate as further surfactant.
  • Suitable cationic polymers are, for example
  • quaternized cellulose derivatives e.g. Polyquaternium-10, as are commercially available under the names Celquat and Polymer JR cationic guar derivatives, in particular those sold under the trade names Cosmedia Guar and Jaguar products
  • polymeric dimethyldiallylammonium salts and their copolymers with esters and amides of acrylic acid and methacrylic acid in particular the products sold under the names Merquat 100 and Merquat 550 commercially available.
  • cationic polymer or mixtures of cationic polymers in a concentration of 0.01 to 2% by weight, preferably in a concentration of 0.05 to 1.5% by weight and more preferably of 0.1 to 1.0% by weight, in each case based on the total weight of the preparation to use.
  • compositions according to the invention optionally contain, in addition to the aforementioned substances, the additives customary in cosmetics, for example perfumes, dyes, antimicrobials, moisturizing agents, complexing and sequestering agents, pearlescing agents, plant extracts, vitamins, active ingredients, preservatives, bactericides, pigments containing a have coloring, thickening, softening, wetting and / or moisturizing substances, or other conventional ingredients of a cosmetic or dermatological formulation such as alcohols, polyols, polymers, foam stabilizers, electrolytes, organic solvents or silicone derivatives.
  • the additives customary in cosmetics for example perfumes, dyes, antimicrobials, moisturizing agents, complexing and sequestering agents, pearlescing agents, plant extracts, vitamins, active ingredients, preservatives, bactericides, pigments containing a have coloring, thickening, softening, wetting and / or moisturizing substances, or other conventional ingredients of a cosmetic or dermatological formulation such as alcohols
  • inventively advantageous usable Wrk-, auxiliaries and additives are by no means limited to the substances and compounds mentioned here by name.
  • Particularly advantageous active ingredients according to the invention are in particular niacinamide, panthenol, polidocanol, [gamma] -aryzanol, ubiquinones (in particular Q-10) creatine, creatinine, biotin (vitamin H), vitamin E and vitamin E acetate, plant extracts, such as e.g. Bamboo extract, water-lily extract, alpha-hydroxy acids, e.g. Citric acid, tartaric acid, malic acid, salts, e.g. Calcium salts or marine minerals, BHT, propyl gallate, and UV filters (e.g., particularly favorably benzophenone-4).
  • niacinamide e.g., panthenol, polidocanol, [gamma] -aryzanol, ubiquinones (in particular Q-10) creatine, creatinine, biotin (vitamin H), vitamin E and vitamin E acetate
  • plant extracts such as e.g. Bamboo extract, water-l
  • such active ingredients may advantageously be present in concentrations (individual concentration of an active substance) of from 0.001 to 5% by weight, based in each case on the total weight of the preparation, in the preparations.
  • effect substances for example color and / or bulking beads, glitter substances and the like
  • effect substances for example color and / or bulking beads, glitter substances and the like
  • Opacifying agents / pearlescing agents or mixtures which are advantageous according to the invention include:
  • PEG-3 distearate e.g., CUTINA TS from Cognis
  • glycol distearate glycerol, laureth-4 and
  • Cocamidopropylbetaine e.g., Euperlan PK 3000 and Euperlan PK 4000 the
  • Styrene / acrylate copolymers e.g., Acusol OP 301 from Rohm & Haas
  • antioxidants which are suitable or customary for cosmetic and / or dermatological applications can be used as favorable antioxidants.
  • the amount of antioxidants (one or more compounds) in the preparations is preferably from 0.001 to 30% by weight, particularly preferably from 0.05 to 20% by weight, in particular from 1 to 10% by weight, based on the total weight of the preparation ,
  • the cosmetic or dermatological preparation in the sense of the present invention is a solution or emulsion or dispersion, it is possible to use as solvent:
  • Oils such as triglycerides of capric or caprylic acid, but preferably castor oil;
  • Fats, waxes and other natural and synthetic fats preferably esters of fatty acids with lower C-number alcohols, e.g. with isopropanol, propylene glycol or glycerol, or esters of fatty alcohols with alkanoic acids of low C number or with fatty acids;
  • Alcohols, diols or polyols of low C number, and their ethers preferably ethanol, isopropanol, propylene glycol, glycerol, ethylene glycol, ethylene glycol monoethyl or monobutyl ether, propylene glycol monomethyl, monoethyl or monobutyl ether, diethylene glycol monomethyl or monoethyl ether and analog products.
  • mixtures of the abovementioned solvents are used.
  • alcoholic solvents water can be another ingredient.
  • Cosmetic preparations in the sense of the present invention can also be present as gels which, in addition to an effective content of the active substance according to the invention and solvents customarily used for this purpose, preferably water, are still organic thickening agents, for example gum arabic, xanthan gum, sodium alginate, cellulose derivatives, preferably methylcellulose, hydroxymethylcellulose, hydroxyethylcellulose, hydroxypropylcellulose, hydroxypropylmethylcellulose or inorganic thickening agents, e.g. For example, aluminum silicates such as Benetonite, or a mixture of polyethylene glycol and polyethylene glycol stearate or distearate.
  • organic thickening agents for example gum arabic, xanthan gum, sodium alginate, cellulose derivatives, preferably methylcellulose, hydroxymethylcellulose, hydroxyethylcellulose, hydroxypropylcellulose, hydroxypropylmethylcellulose or inorganic thickening agents, e.g.
  • aluminum silicates such as Benetonite, or
  • Embodiments of the present invention which are advantageous according to the invention are characterized in that the preparation likewise contains polyacrylates as thickening agent.
  • Polyacrylates which are advantageous according to the invention are polymers of acrylic acid, in particular those selected from the group of the so-called carbomers or carbopols (Carbopol ⁇ (R)> is actually a registered trademark of the B.F. Goodrich Company).
  • Advantageous carbopols are for example the types 907, 910, 934, 940, 941, 951, 954, 980, 981, 1342, 1382, 2984 and 5984 or also the types ETD (Easy-to-disperse) 2001, 2020, 2050, Aqua -SF1 wherein these compounds can be present individually or in any desired combinations with one another.
  • the copolymers of C10-30-alkyl acrylates and one or more monomers of acrylic acid, methacrylic acid or their esters which are comparable to the acrylate-alkyl acrylate copolymers are advantageous.
  • the INCI name for such compounds is "Acrylates / C 10-30 Alkyl Acrylate Crosspolymer". Particularly advantageous are those available under the trade names Pemulen TR1 and Pemulen TR2 from the B.F. Goodrich Company.
  • the thickener is present in the gel e.g. in an amount between 0, 1 and 30 wt .-%, preferably between 0.5 and 15 wt .-%, included.
  • Rewopol SB CS disodium PEG-5 lauryl citrate -30% Evonik Gold50 sulfosuccinate schmidt
  • phase A The ingredients of phase A are mixed until a homogeneous phase is obtained.
  • Eumulgin HRE 40 is melted at a temperature of about 40 ° C.
  • the remaining Phase B raw materials are added to the Eumulgin HRE 40.
  • the phase is mixed homogeneously and added to phase A.
  • phase C The addition of the ingredients of phase C is carried out with stirring in the order given. Both shower gels have an L / D value of approx. 1.5.
  • inventive product A is clearly superior to the comparison product with respect to all features.
  • Phase A Index 1 The Inhalants of Phase A Index 1 are mixed together until a homogeneous phase is obtained. The remaining ingredients of phase A are added in the order listed. Carbopol Aqua SF-1 is filtered before addition. It is stirred until a clear phase has emerged. Eumulgin HRE 40 is melted at a temperature of about 40 ° C. The remaining Phase B raw materials are added to the Eumulgin HRE 40. The phase is mixed homogeneously and added to phase A.
  • Ucare Polymer JR 400 is sprinkled into the water of phase C.
  • the phase C is heated with stirring to about 70 ° C until a clear solution is formed.
  • Phase C is cooled and added to Phase A.
  • Both facial cleaners have an L / D value of about 20.
  • inventive product A is clearly superior to the comparison product with respect to all features. example recipes
  • the preparations have an L / D value of approx. 10.
  • phase A The Inhalstscher of phase A are mixed together until a homogeneous phase is formed.
  • Ucare Polymer JR 400 is interspersed in the water of phase B.
  • the phase B is heated with stirring to about 70 ° C until a clear solution is formed.
  • Phase B is cooled and added to Phase A.
  • Eumulgin HRE 40 is melted at a temperature of about 40 ° C.
  • the perfume is given to Eumulgin HRE 40.
  • the phase is mixed homogeneously and added to phase A.
  • phase D The addition of the ingredients of phase D is carried out in the order given. It is stirred until a homogeneous shampoo is formed.
  • Ucare Polymer JR 400 is interspersed in the water of phase B.
  • the phase B is heated with stirring to about 70 ° C until a clear solution is formed.
  • Phase B is cooled and added to Phase A.
  • Eumulgin HRE 40 is melted at a temperature of about 40 ° C.
  • the remaining Phase C raw materials are added to the Eumulgin HRE 40.
  • the phase is mixed homogeneously and added to phase A.
  • phase D The addition of the ingredients of phase D is carried out with stirring in the order given.
  • the preparations 2.1 to 2.4 have an L / D value of about 2.
  • the preparation 2.5 has an L / D value of about 5.
  • Phase A Index 1 The Inhalants of Phase A Index 1 are mixed together until a homogeneous phase is obtained. The remaining ingredients of phase A are added in the order listed. Carbopol Aqua SF-1 is filtered before addition. It is stirred until a clear phase has emerged. Eumulgin HRE 40 is melted at a temperature of about 40 ° C. The remaining Phase B raw materials are added to the Eumulgin HRE 40. The phase is mixed homogeneously and added to phase A.
  • Ucare Polymer JR 400 is sprinkled into the water of phase C.
  • the phase C is heated with stirring to about 70 ° C until a clear solution is formed.
  • Phase C is cooled and added to Phase A.
  • the preparations have an L / D value of about 20.
  • the Carbopol 980 is sprinkled into the water of phase A and dispersed homogeneously with a magic wand. Then Keltrol CG-RD is added and stirred until a homogeneous phase is obtained.
  • phase B The raw materials of phase B are mixed together and stirred until a homogeneous phase is obtained.
  • Phase B is added to Phase A.
  • the raw materials of phase C without the perfume are mixed and heated with stirring to 50 ° C until a homogeneous phase is formed. The mixture is cooled and the perfume is added.
  • Phase C is added to Phase A.
  • phase D is added to phase A.
  • the preparations have an L / D value of about 20.

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Birds (AREA)
  • Epidemiology (AREA)
  • Dermatology (AREA)
  • Cosmetics (AREA)
  • Agricultural Chemicals And Associated Chemicals (AREA)

Abstract

Disclosed are active ingredient combinations of (i) acidic preservatives and (ii) one or more glyceryl glucosides.

Description

Beiersdorf Aktiengesellschaft  Beiersdorf Aktiengesellschaft
Beschreibung description
Wirkstoffkombinationen aus Glucosylglyceriden und einem oder mehreren milden Drug combinations of glucosylglycerides and one or more mild
Tensiden  surfactants
Die vorliegende Erfindung betrifft Wirkstoffkombinationen aus Glucosylglyceriden und einem oder mehreren milden Tensiden sowie deren Verwendung auf dem Gebiete der kosmetischen sowie der pharmazeutischen Dermatologie. The present invention relates to active ingredient combinations of glucosylglycerides and one or more mild surfactants and their use in the field of cosmetic and pharmaceutical dermatology.
Insbesondere betrifft die vorliegende Erfindung Wirkstoffe und kosmetische oder dermatologische Zubereitungen, solche Wrkstoffkombinationen enthaltend. In particular, the present invention relates to active ingredients and cosmetic or dermatological preparations containing such drug combinations.
Bevorzugt betrifft die vorliegende Erfindung waschaktive kosmetische Zubereitungen. The present invention preferably relates to washing-active cosmetic preparations.
Die äußerste Schicht der Epidermis, das Stratum corneum (Hornschicht), ist als wichtige Barriereschicht von besonderer Bedeutung u.a. für den Schutz vor Umwelteinflüssen und Austrocknung. Die Hornschicht wird im Kontakt mit der Umwelt ständig abgenutzt und muß deshalb ununterbrochen erneuert werden. The outermost layer of the epidermis, the stratum corneum (horny layer), is of particular importance as an important barrier layer, inter alia. for protection against environmental influences and dehydration. The horny layer is constantly worn in contact with the environment and must therefore be renewed continuously.
Ein heute in der Fachwelt weitverbreitetes Hautmodell faßt das Stratum corneum als Zwei-Komponenten-System, ähnlich einer Ziegelsteinmauer (Ziegelstein-Mörtel- Modell), auf. In diesem Modell entsprechen die Korneozyten (Hornzellen) den Ziegelsteinen, die kompliziert zusammengesetzte Lipidmembran in den Interzellularräumen entspricht dem Mörtel. A skin model widely used today in the art understands the stratum corneum as a two-component system, similar to a brick wall (brick-mortar model). In this model, the corneocytes (horny cells) correspond to the bricks, the complex composite lipid membrane in the intercellular spaces corresponds to the mortar.
Außer ihrer Barrierewirkung gegen externe chemische und physikalische Einflüsse tragen die epidermalen Lipide auch zum Zusammenhalt der Hornschicht bei und haben Einfluß auf die Hautglätte. Im Gegensatz zu den Talgdrüsenlipiden, die keinen geschlossenen Film auf der Haut ausbilden, sind die epidermalen Lipide über die gesamte Hornschicht verteilt. Das äußerst komplexe Zusammenwirken der feuchtigkeitsbindenden Substanzen und der Lipide der oberen Hautschichten ist für die Regulation der Hautfeuchte sehr wichtig. Daher enthalten Kosmetika in der Regel, neben ausgewogenen Lipidabmischungen und Wasser, wasserbindende Substanzen. Hierzu zählen u.a. Polyole wie Glycerin, Sorbit und Xylit, ethoxylierte Polyole sowie hydrolysierte Proteine. Weitere Anwendung finden die im natürlichen Feuchthaltefaktor (sogenannter Natural Moisturizing Factor = NMF) enthaltenen Substanzen, wie z.B. Harnstoff, Kohlenhydrate (z. B. Glucose) und Aminosäuren (z. B. Serin). Diese Substanzen sind daher für die Pflegeleistung eines kosmetischen Produktes von besonderer Bedeutung, insbesondere auch aufgrund ihrer relativ guten Haut- und Schleimhautverträglichkeit. In addition to their barrier effect against external chemical and physical influences, the epidermal lipids also contribute to the cohesion of the horny layer and have an influence on the skin smoothness. In contrast to the sebaceous gland lipids, which do not form a closed film on the skin, the epidermal lipids are distributed over the entire horny layer. The extremely complex interaction of the moisture-binding substances and the lipids of the upper skin layers is very important for the regulation of skin moisture. Therefore, cosmetics usually contain, in addition to balanced lipid mixtures and water, water-binding substances. These include polyols such as glycerin, sorbitol and xylitol, ethoxylated polyols and hydrolyzed proteins. Other uses include those contained in the natural moisturizing factor (so-called Natural Moisturizing Factor = NMF), such as urea, carbohydrates (eg glucose) and amino acids (eg serine). These substances are therefore of particular importance for the care performance of a cosmetic product, in particular because of their relatively good skin and mucous membrane compatibility.
Der Wunsch nach sauberer Haut ist wohl so alt wie die Menschheit, denn Schmutz, Schweiss und Reste abgestorbener Hautpartikel bieten den idealen Nährboden für Krankheitserreger und Parasiten aller Art. Die Lust an der Körperhygiene wurde stetig verstärkt, als in den 60er Jahren des 20. Jahrhunderts neben der "klassischen" Seife auch flüssige Reinigungsmittel mit neu entwickelten synthetischen Tensiden formuliert werden konnten. Baden und Duschen sind seitdem aus unserem täglichen Leben nicht mehr wegzudenken. Den Verbrauchern stehen heutzutage eine Vielzahl von Produkten für die Reinigung der verschiedenen Körperpartien zur Verfügung. The desire for clean skin is probably as old as humanity, because dirt, sweat and remains of dead skin particles provide the ideal breeding ground for pathogens and parasites of all kinds. The desire for personal hygiene was steadily increased, as in the 60s of the 20th century In addition to the "classic" soap and liquid detergents could be formulated with newly developed synthetic surfactants. Since then, bathing and showering have become indispensable in our daily lives. Consumers today have a variety of products available for cleaning the various body parts.
Reinigung bedeutet das Entfernen von (Umwelt-) Schmutz und bewirkt damit eine Erhöhung des psychischen und physischen Wohlbefindens. Die Reinigung der Oberfläche von Haut und Haaren ist ein sehr komplexer, von vielen Parametern abhängiger Vorgang. Zum einen sollen von außen kommende Substanzen wie beispielsweise Kohlenwasserstoffe oder anorganische Pigmente aus unterschiedlichsten Umfeldern sowie Rückstände von Kosmetika oder auch unerwünschte Mikroorganismen möglichst vollständig entfernt werden. Zum anderen sind körpereigene Ausscheidungen wie Schweiß, Sebum, Haut- und Haarschuppen ohne tiefgreifende Eingriffe in das physiologische Gleichgewicht abzuwaschen. Cleaning means the removal of (environmental) dirt and thus causes an increase in mental and physical well-being. Cleaning the surface of the skin and hair is a very complex process, depending on many parameters. On the one hand, substances coming from outside such as, for example, hydrocarbons or inorganic pigments from a wide variety of environments as well as residues of cosmetics or undesired microorganisms should be removed as completely as possible. On the other hand, the body's excretions such as sweat, sebum, dandruff and hair dandruff are to be washed off without profound interventions in the physiological balance.
Kosmetische Reinigungszubereitungen für Haut und Haare, die beispielsweise als Shampoos, Duschbäder und flüssige Seifen angeboten werden, müssen nicht nur ein gutes Reinigungsvermögen aufweisen, sondern sollen weiterhin gut verträglich sein und einen für Haut und Haare pflegenden Effekt aufweisen. Auch bei einer häufigen Anwendung soll es dabei nicht zu einer Entfettung oder Trockenheit der Haut oder der Haare kommen. Cosmetic cleansing preparations for the skin and hair, which are offered, for example, as shampoos, shower baths and liquid soaps, not only have to have a good cleaning power, but should continue to be well-tolerated and have a skin and hair-care effect. Also at one Frequent use should not lead to defatting or dryness of the skin or hair.
Kosmetische Reinigungszubereitungen, die besonders schonend zu Haut und Haar sind, enthalten in der Regel besonders milde Tenside, wie z.B. Zuckertenside oder Aminosäuretenside. Während diese Tenside eine schonende Reinigung der Haut und Haare ermöglichen, ist das Schaumvermögen dieser Tenside nicht geeignet, die Anforderungen der Verbraucher an den Schaum eines Reinigungsprodukts zu erfüllen. Der Schaum sollte dabei besonders ergiebig, cremig und reichhaltig sein. Weiterhin sind die sensorischen Eigenschaften von Reinigungszubereitungen enthaltend milde Tenside nicht zufrieden stellend. Cosmetic cleansing preparations which are particularly gentle to the skin and hair usually contain particularly mild surfactants, such as e.g. Sugar surfactants or amino acid surfactants. While these surfactants allow gentle cleansing of the skin and hair, the foaming power of these surfactants is not adequate to meet consumers' requirements for the foam of a cleansing product. The foam should be particularly rich, creamy and rich. Furthermore, the sensory properties of cleansing formulations containing mild surfactants are unsatisfactory.
Auf der anderen Seite enthalten kosmetische Reinigungszubereitungen, die einen besonders cremigen und reichhaltigen Schaum erzeugen, oft hohe Mengen an anionischem Sulfattensid, welches dafür bekannt ist, besonders aggressiv zur Haut zu sein und eine Austrocknung der Haut zu verursachen, die sich oft durch gerötete, rissige und spannende Haut offenbart. On the other hand, cosmetic cleansing preparations which produce a particularly creamy and rich lather often contain high levels of anionic sulphate surfactant, which is known to be particularly aggressive to the skin and cause dehydration of the skin, often through reddened, cracked and exciting skin revealed.
Es besteht daher der Bedarf an Zubereitungen, die die Nachteile des Standes der Technik beheben. There is therefore a need for preparations which overcome the disadvantages of the prior art.
Es war nach all diesem überraschend und nicht vorhersehbar, dass Wrkstoffkom- binationen aus After all this it was surprising and unpredictable that fuel combinations failed
(i) einem oder mehreren milden Tensiden  (i) one or more mild surfactants
und and
(ii) einem oder mehreren Glucosylglyceriden  (ii) one or more glucosylglycerides
bzw. kosmetische Zubereitungen, solche Wirkstoffkombinationen enthaltend, die Nachteile des Standes der Technik beseitigen. or cosmetic preparations containing such combinations of active substances, eliminate the disadvantages of the prior art.
Es wurde überraschend festgestellt, dass Kombinationen aus milden Tensiden mit Glucosylglyceriden die Nachteile des Standes der Technik beheben können. Diese Zubereitungen zeichnen sich durch eine sehr gute Hautverträglichkeit und hervorragende sensorische Eigenschaften im Vergleich zu Zubereitungen des Standes der Technik aus. Ferner haben diese Zubereitungen sehr gute Schaumeigenschaften. Die Milde eines Tensides oder Tensidsystems lässt sich durch die Bestimmung der Quotienten aus Hämolysewert und Denaturierungsindex charakterisieren. Der Quotient L/D repräsentiert das Verhältnis von Hämolysewert (L) zu Denaturierungsindex (D) und wird durch den Standard RBC-Test bestimmt. It has surprisingly been found that combinations of mild surfactants with glucosylglycerides can overcome the disadvantages of the prior art. These preparations are characterized by a very good skin compatibility and excellent sensory properties in comparison to preparations of the prior art. Furthermore, these preparations have very good foam properties. The mildness of a surfactant or surfactant system can be characterized by determining the quotients of hemolysis value and denaturation index. The quotient L / D represents the ratio of hemolysis value (L) to denaturation index (D) and is determined by the standard RBC test.
Der Standard RBC-Test dient zur Abschätzung von in-vivo Augenschleimhautreiz- potentialen von Tensiden und tensidhaltigen Produkten. Das Verfahren beruht auf der Tatsache, dass Tenside stark mit Zellmembranen und Proteinen interagieren. Beide Effekte werden photometrisch durch Analyse des natürlichen Blutfarbstoffs Oxyhämoglobin (HbOa) bestimmt. Im Gegensatz zu anderen zellbasierten Systemen ist der RBC-Test in der Lage zwischen Schädigungen der Zellmembran (Hä- molyse) und Proteindenaturierung (Denaturierungsindex) zu differenzieren. The standard RBC test is used to estimate in vivo ocular irritation potentials of surfactants and surfactant-containing products. The method relies on the fact that surfactants interact strongly with cell membranes and proteins. Both effects are determined photometrically by analysis of the natural blood dye oxyhemoglobin (HbOa). In contrast to other cell-based systems, the RBC test is able to differentiate between damage to the cell membrane (hemolysis) and protein denaturation (denaturation index).
Hämolyse hemolysis
Ein definiertes Aliquot isolierter Kalbserythrozyten wird mit einer Reihe steigender Konzentrationen des zu untersuchenden Musters (Stammlösung für Rohstoffe 0, 1 Gew.-% Aktivgehalt der waschaktiven Substanz in PBS; Stammlösung für Fertigprodukte 1 : 100 w/v in PBS) für 10 Minuten unter Schütteln bei RT inkubiert. PBS ist ein üblicher Standard-Phosphat-Puffer (pH 7,4) mit folgender Zusammensetzung: A defined aliquot of isolated calf RBCs is shaken with a series of increasing concentrations of the sample to be tested (stock solution for raw materials 0, 1 wt% active content of the detergent in PBS, stock for finished products 1: 100 w / v in PBS) for 10 minutes incubated at RT. PBS is a common standard phosphate buffer (pH 7.4) having the following composition:
Na2HP04 ■ 2 H20 3,95 g Na 2 HP0 4 ■ H 2 0 2 3.95 g
KH2P04 0,76 g KH 2 P0 4 0.76 g
NaCI 7,20 g  NaCl 7.20 g
Glucose■ 1 H20 1 ,80 g Glucose ■ 1H 2 0 1, 80 g
Aqua dest. oder "highly purified water" ad 1000 ml  Distilled water or "highly purified water" ad 1000 ml
Die Inkubationsperiode wird durch schnelle Hochgeschwindigkeitszentrifugation beendet. Nach Zentrifugation werden die gewonnenen Überstände photometrisch auf ihren Gehalt an freigesetztem Hämoglobin (Hb02) bei 530 nm analysiert. Daraus wird der relative Hämolysegrad berechnet und die Konzentrations-Response- Kurve mit dem H50-Wert [μΙ/ml] als Kenngröße bestimmt. Dieser gibt die Konzentration des Prüfmusters an, bei der 50% des Hämoglobins freigesetzt werden. Je höher der Wert, desto verträglicher ist das untersuchte Muster. The incubation period is terminated by rapid high speed centrifugation. After centrifugation, the supernatants obtained are analyzed photometrically for their content of released hemoglobin (HbO 2) at 530 nm. From this, the relative degree of hemolysis is calculated and the concentration-response curve with the H50 value [μΙ / ml] is determined as a parameter. This indicates the concentration of the test sample at which 50% of hemoglobin is released. The higher the value, the more compatible the sample studied.
Hb02-Denaturierung Ein definiertes Aliquot isolierter Kalbserythrozyten wird mit einer fixen Konzentration des Prüfmusters (Konzentration für Rohstoffe 0, 1 Gew.-% Aktivgehalt der waschaktiven Substanz in PBS; Konzentration für Fertigprodukte 1 % w/v in PBS) für 10 Minuten unter Schütteln bei RT inkubiert und dann zentrifugiert. Die Änderung der spektralen Absorption bei 575 nm und 540 nm wird im Vergleich zum nativen Hb02 gemessen. Aus dem Verhältnis der Absorptionswerte zueinander wird der Denatu- rierungsindex DI [%] berechnet. Als 100%-Standard dient Natriumlaurylsulfat (0, 1 % Aktivgehalt). Hb0 2 denaturation A defined aliquot of isolated calf RBCs is incubated with a fixed concentration of the test sample (concentration for raw materials 0, 1% by weight active content of the detergent in PBS, concentration for finished products 1% w / v in PBS) for 10 minutes with shaking at RT and then centrifuged. The change in spectral absorption at 575 nm and 540 nm is measured in comparison to the native Hb0 2 . The denaturation index DI [%] is calculated from the ratio of the absorption values to one another. The 100% standard is sodium lauryl sulfate (0, 1% active content).
Je geringer der Wert, desto verträglicher ist das untersuchte Muster. L/D-Quotient  The lower the value, the more compatible the pattern studied. L / D ratio
Der Quotient (L/D-Wert) stellt das Verhältnis der Kenngrößen von Hämolyse (H50) und Denaturierung (DI) dar und wird zur Charakterisierung und Klassifizierung der untersuchten Prüfmuster verwendet. The quotient (L / D value) represents the ratio of the parameters of hemolysis (H50) and denaturation (DI) and is used to characterize and classify the examined test samples.
Tenside oder Tensidmischungen werden erfindungsgemäß als mild angesehen, wenn der L/D-Wert mindestens 1 beträgt. Zum Vergleich dazu hat das häufig in Reinigungsprodukten eingesetzte Natriumlaurylethersulfat einen L/D-Wert von ca. 0,3 und wird als reizend klassifiziert. Sofern in einer Tensidmischung Natriumlaurylethersulfat eingesetzt wird, hat die resultierende Tensidmischung erfindungsgemäß einen L/D-Wert von mindestens 1. Surfactants or surfactant mixtures are considered to be mild according to the invention if the L / D value is at least 1. By comparison, the sodium lauryl ether sulfate commonly used in cleaning products has an L / D of about 0.3 and is classified as irritating. If sodium lauryl ether sulfate is used in a surfactant mixture, the resulting surfactant mixture according to the invention has an L / D value of at least 1.
Bevorzugte milde Tenside sind Preferred mild surfactants are
Alkylpolyglucoside wie z.B. Laurylglucosid, Decylglucosid und  Alkyl polyglucosides, e.g. Lauryl glucoside, decyl glucoside and
Cocoglucosid,  cocoglucoside,
Amphoacetate wie z.B. Natriumcocoamphoacetat,  Amphoacetates such as e.g. , sodium,
Dinatriumcocoamphodiacetat und Natriumlauroamphoacetat,  Disodium cocoamphodiacetate and sodium lauroamphoacetate,
Betaintenside wie z.B. Cocamidopropylbetain oder Cocobetain,  Betaine surfactants such as e.g. Cocamidopropyl betaine or cocobetaine,
Aminosäuretenside wie z.B. Natriumlauroylglutamat und  Amino acid surfactants such as e.g. Sodium lauroylglutamate and
Dinatriumcocoylglutamat,  Dinatriumcocoylglutamat,
Ethoxylierte Glyceride wie z.B. PEG-7 Glycerylcocoat,  Ethoxylated glycerides such as e.g. PEG-7 glyceryl cocoate,
Taurate wie z.B. Natriummethylcocoyltaurat,  Taurates such as e.g. sodium methyl,
Sarkosinate wie z.B. Natriumlauroylsarcosinat  Sarcosinates, e.g. sodium lauroyl
Sulfosuccinate wie z.B. Dinatrium PEG-5 Laurylcitratsulfosuccinat In der folgenden Tabelle sind bevorzugte milde Tenside mit ihren L/D-Werten aufgeführt: Sulfosuccinates such as disodium PEG-5 lauryl citrate sulfosuccinate The following table lists preferred mild surfactants with their L / D values:
Besonders bevorzugte milde Tenside sind Alkylpolyglucoside, wie z.B. Laurylglucosid und Decylglucosid, Betaintenside, wie z.B. Cocamidopropylbetain oder Cocobetain, Aminosäuretenside, wie z.B. Natriumlauroylglutamat und Dinatriumcocoylglutamat und Ethoxylierte Glyceride wie z.B. PEG-7 Glycerylcocoat. Particularly preferred mild surfactants are alkyl polyglucosides, e.g. Lauryl glucoside and decyl glucoside, betaine surfactants, e.g. Cocamidopropyl betaine or cocobetaine, amino acid surfactants, such as e.g. Sodium lauroyl glutamate and disodium cocoyl glutamate and ethoxylated glycerides such as e.g. PEG-7 glyceryl cocoate.
Bevorzugte Konzentration der milden Tenside ist 0,01 bis 20%, besonders bevorzugt 0, 1-15%, besonders bevorzugt 1 % - 10%. Preferred concentration of the mild surfactants is 0.01 to 20%, more preferably 0, 1-15%, most preferably 1% - 10%.
Vorteilhaft im Sinne der vorliegenden Erfindung sind Glucosylglyceride der allgemeinen Formel For the purposes of the present invention, glucosylglycerides of the general formula are advantageous
und/oder der allgemeinen Formel and / or the general formula
und/oder der allgemeinen Formel and / or the general formula
und/oder der allgemeinen Formel and / or the general formula
werden erfindungsgemäß bevorzugt. are preferred according to the invention.
Erfindungsgemäß sind solche Zubereitungen besonders vorteilhaft, die dadurch gekennzeichnet sind, daß das oder die Glucosylglycerid in der Wasser- und/oder Ölphase in Konzentrationen von 0,001 - 40,00 Gew.-%, bevorzugt 0,005 - 15,00 Gew.-%, besonders bevorzugt 0,01 - 12,00 Gew.-%, jeweils bezogen auf das Gesamtgewicht der Zusammensetzung, vorliegen. According to the invention, those preparations are particularly advantageous, which are characterized in that the glucosylglyceride or in the water and / or oil phase in concentrations of 0.001 to 40.00 wt .-%, preferably 0.005 to 15.00 wt .-%, especially preferably 0.01 to 12.00 wt .-%, each based on the total weight of the composition.
Es ist erfindungsgemäß vorteilhaft, das molare Verhältnis von einem oder mehreren Glucosylglyceriden zu einem oder mehreren milden Tensiden aus dem Bereich von 100 : 1 bis 1 : 1000 , bevorzugt 50 : 1 bis 1 : 500, insbesondere bevorzugt 20 : 1 bis 1 : 100 zu wählen. Erfindungsgemäß vorteilhaft ist die Verwendung der erfindungsgemäßen Zubereitung als kosmetische Reinigungszubereitung. Dabei wird die erfindungsgemäße Zubereitung bevorzugt als Duschgel, Schaum- und Wannenbad, Shampoo und/oder Gesichtsreiniger verwendet. It is advantageous according to the invention, the molar ratio of one or more glucosylglycerides to one or more mild surfactants from the range of 100: 1 to 1: 1000, preferably 50: 1 to 1: 500, particularly preferably 20: 1 to 1: 100 to choose. The use of the preparation according to the invention as a cosmetic cleansing preparation is advantageous according to the invention. The preparation according to the invention is preferably used as a shower gel, foam bath and bath, shampoo and / or facial cleanser.
Es ist erfindungsgemäß vorteilhaft, wenn die erfindungsgemäße kosmetische Zubereitung in einer Flasche, Quetschflasche, Pumpspray-, oder Aerosoldose aufbewahrt und aus dieser heraus angewendet werden. Entsprechend sind auch Flaschen, Quetschflaschen, Doppelkammerpackmittel, Pumpspray-, oder Aerosoldosen, welche eine erfindungsgemäße Zubereitung enthalten, erfindungsgemäß. It is advantageous according to the invention if the cosmetic preparation according to the invention is stored in a bottle, squeeze bottle, pump spray or aerosol can and applied out of it. Correspondingly, bottles, squeeze bottles, double-chamber packing, pump spray or aerosol cans containing a preparation according to the invention are also suitable according to the invention.
Die erfindungsgemäße Zubereitung enthält vorteilhaft weitere Tenside. Diese liegen erfindungsgemäß vorteilhaft in einer Konzentration von 0, 1 bis 5 Gewichts-%, und erfindungsgemäß bevorzugt in einer Konzentration von 1 bis 3 Gewichts-%, jeweils bezogen auf das Gesamtgewicht der Zubereitung, in der Zubereitung vor. Erfindungsgemäß besonders bevorzugt ist dabei der Einsatz von Nariumlaurylethersulfat oder Natriummyristylethersulfat als weiterem Tensid. The preparation according to the invention advantageously contains further surfactants. These are according to the invention advantageously in a concentration of 0, 1 to 5% by weight, and according to the invention preferably in a concentration of 1 to 3% by weight, based in each case on the total weight of the preparation in the preparation. Particularly preferred according to the invention is the use of sodium lauryl ether sulfate or sodium myristyl ether sulfate as further surfactant.
Es ist ebenfalls vorteilhaft, den Zubereitungen im Sinne der vorliegenden Erfindung kationische Polymere zuzufügen. Geeignete kationische Polymere sind beispielsweise It is likewise advantageous to add cationic polymers to the preparations for the purposes of the present invention. Suitable cationic polymers are, for example
quaternisierte Cellulose-Derivate, wie z.B. Polyquaternium-10, wie sie unter den Bezeichnungen Celquat und Polymer JR im Handel erhältlich sind kationische Guar-Derivate, wie insbesondere die unter den Handelsnamen Cosmedia Guar und Jaguar vertriebenen Produkte  quaternized cellulose derivatives, e.g. Polyquaternium-10, as are commercially available under the names Celquat and Polymer JR cationic guar derivatives, in particular those sold under the trade names Cosmedia Guar and Jaguar products
polymere Dimethyldiallylammoniumsalze und deren Copolymere mit Estern und Amiden von Acrylsäure und Methacrylsäure, wie insbesondere die unter den Bezeichnungen Merquat 100 und Merquat 550 im Handel erhältlichen Produkte.  polymeric dimethyldiallylammonium salts and their copolymers with esters and amides of acrylic acid and methacrylic acid, in particular the products sold under the names Merquat 100 and Merquat 550 commercially available.
Vorteilhaft im Sinne der vorliegenden Erfindung ist es insbesondere, kationisches Polymer oder Mischungen aus kationischen Polymeren in einer Konzentration von 0.01 bis 2 Gewichts-%, bevorzugt in einer Konzentration von 0.05 bis 1.5 Gewichts- % und besonders bevorzugt von 0.1 bis 1.0 Gewichts-%, jeweils bezogen auf das Gesamtgewicht der Zubereitung, einzusetzen. Die Zusammensetzungen enthalten gemäß der Erfindung außer den vorgenannten Substanzen gegebenenfalls die in der Kosmetik üblichen Zusatzstoffe, beispielsweise Parfüm, Farbstoffe, antimikrobielle Stoffe, rückfettende Agentien, Komplexierungs- und Sequestrierungsagentien, Perlglanzagentien, Pflanzenextrakte, Vitamine, Wirkstoffe, Konservierungsmittel, Bakterizide, Pigmente, die eine färbende Wirkung haben, Verdickungsmittel, weichmachende, anfeuchtende und/oder feuchthaltende Substanzen, oder andere übliche Bestandteile einer kosmetischen oder dermatologischen Formulierung wie Alkohole, Polyole, Polymere, Schaumstabilisatoren, Elektrolyte, organische Lösemittel oder Silikonderivate. In the context of the present invention, it is advantageous, in particular, cationic polymer or mixtures of cationic polymers in a concentration of 0.01 to 2% by weight, preferably in a concentration of 0.05 to 1.5% by weight and more preferably of 0.1 to 1.0% by weight, in each case based on the total weight of the preparation to use. The compositions according to the invention optionally contain, in addition to the aforementioned substances, the additives customary in cosmetics, for example perfumes, dyes, antimicrobials, moisturizing agents, complexing and sequestering agents, pearlescing agents, plant extracts, vitamins, active ingredients, preservatives, bactericides, pigments containing a have coloring, thickening, softening, wetting and / or moisturizing substances, or other conventional ingredients of a cosmetic or dermatological formulation such as alcohols, polyols, polymers, foam stabilizers, electrolytes, organic solvents or silicone derivatives.
Die erfindungsgemäß vorteilhaften einsetzbaren Wrk-, Hilfs- und Zusatzstoffe sind dabei keineswegs auf die hier namentlich erwähnten Stoffe und Verbindungen beschränkt. The inventively advantageous usable Wrk-, auxiliaries and additives are by no means limited to the substances and compounds mentioned here by name.
Erfindungsgemäß besonders vorteilhafte Wrkstoffe sind insbesondere Niacinamid, Panthenol, Polidocanol, [gamma]-Oryzanol, Ubichinone (insbesondere Q-10) Krea- tin, Kreatinin, Biotin (Vitamin H), Vitamin E und Vitamin E-acetat, Pflanzenextrakte, wie z.B. Bambusextrakt, Wasserlilienextrakt, den alpha-Hydroxysäuren, wie z.B. Zitronensäure, Weinsäure, Apfelsäure, Salzen, wie z.B. Calciumsalzen oder Meeresmineralien, BHT, Propylgallat sowie UV-Filter (z.B. besonders vorteilhaft Benzophenon-4). Particularly advantageous active ingredients according to the invention are in particular niacinamide, panthenol, polidocanol, [gamma] -aryzanol, ubiquinones (in particular Q-10) creatine, creatinine, biotin (vitamin H), vitamin E and vitamin E acetate, plant extracts, such as e.g. Bamboo extract, water-lily extract, alpha-hydroxy acids, e.g. Citric acid, tartaric acid, malic acid, salts, e.g. Calcium salts or marine minerals, BHT, propyl gallate, and UV filters (e.g., particularly favorably benzophenone-4).
Derartige Wrkstoffe können erfindungsgemäß vorteilhaft in Konzentrationen (Einzelkonzentration eines Wrkstoffes) von 0,001 bis 5 Gewichts-%, jeweils bezogen auf das Gesamtgewicht der Zubereitung, in den Zubereitungen enthalten sein. According to the invention, such active ingredients may advantageously be present in concentrations (individual concentration of an active substance) of from 0.001 to 5% by weight, based in each case on the total weight of the preparation, in the preparations.
Es ist ferner erfindungsgemäß von Vorteil, wenn den erfindungsgemäßen Zubereitungen Effektstoffe (z.B. Färb- und/oder Wrkstoffkügelchen, Glitterstoffe u.a.) zugefügt werden und/oder die Zubereitung mit stabilen Luftblasen und -bläschen versehen wird. It is furthermore advantageous according to the invention if effect substances (for example color and / or bulking beads, glitter substances and the like) are added to the preparations according to the invention and / or the preparation is provided with stable air bubbles and bubbles.
Erfindungsgemäß vorteilhafte Trübungsmittel/Perlglanzmittel bzw. Mischungen sind unter anderem: Opacifying agents / pearlescing agents or mixtures which are advantageous according to the invention include:
PEG-3 Distearat (z.B. CUTINA TS der Firma Cognis),  PEG-3 distearate (e.g., CUTINA TS from Cognis),
eine Kombination aus Glycoldistearat, Glycerin, Laureth-4 und a combination of glycol distearate, glycerol, laureth-4 and
Cocamidopropylbetain (z.B. Euperlan PK 3000 und Euperlan PK 4000 derCocamidopropylbetaine (e.g., Euperlan PK 3000 and Euperlan PK 4000 the
Firma Cognis), eine Kombination aus Glycoldistearat, Cocosglucosiden, Glyceryloleat und Glycerylstearat (z.B. Lamesoft TM Benz der Firma Cognis). Company Cognis), a combination of glycol distearate, coco glucosides, glyceryl oleate and glyceryl stearate (eg Lamesoft ™ Benz from Cognis).
Styrol/Acrylat Copolymere (z.B. Acusol OP 301 von Rohm & Haas)  Styrene / acrylate copolymers (e.g., Acusol OP 301 from Rohm & Haas)
Es ist ebenfalls vorteilhaft, den Zubereitungen im Sinne der vorliegenden Erfindung übliche Antioxidantien zuzufügen. Erfindungsgemäß können als günstige Antioxidantien alle für kosmetische und/oder dermatologische Anwendungen geeigneten oder gebräuchlichen Antioxidantien verwendet werden. It is likewise advantageous to add conventional antioxidants to the preparations for the purposes of the present invention. According to the invention, all antioxidants which are suitable or customary for cosmetic and / or dermatological applications can be used as favorable antioxidants.
Die Menge der Antioxidantien (eine oder mehrere Verbindungen) in den Zubereitungen beträgt vorzugsweise 0,001 bis 30 Gew.-%, besonders bevorzugt 0,05 - 20 Gew.-%, insbesondere 1 - 10 Gew.-%, bezogen auf das Gesamtgewicht der Zubereitung. The amount of antioxidants (one or more compounds) in the preparations is preferably from 0.001 to 30% by weight, particularly preferably from 0.05 to 20% by weight, in particular from 1 to 10% by weight, based on the total weight of the preparation ,
Sofern die kosmetische oder dermatologische Zubereitung im Sinne der vorliegenden Erfindung eine Lösung oder Emulsion oder Dispersion darstellt, können als Lösungsmittel verwendet werden: If the cosmetic or dermatological preparation in the sense of the present invention is a solution or emulsion or dispersion, it is possible to use as solvent:
Wasser oder wäßrige Lösungen  Water or aqueous solutions
Öle, wie Triglyceride der Caprin- oder der Caprylsäure, vorzugsweise aber Rizinusöl;  Oils, such as triglycerides of capric or caprylic acid, but preferably castor oil;
Fette, Wachse und andere natürliche und synthetische Fettkörper, vorzugsweise Ester von Fettsäuren mit Alkoholen niedriger C-Zahl, z.B. mit Isopro- panol, Propylenglykol oder Glycerin, oder Ester von Fettalkoholen mit Alkansäuren niedriger C-Zahl oder mit Fettsäuren;  Fats, waxes and other natural and synthetic fats, preferably esters of fatty acids with lower C-number alcohols, e.g. with isopropanol, propylene glycol or glycerol, or esters of fatty alcohols with alkanoic acids of low C number or with fatty acids;
Alkohole, Diole oder Polyole niedriger C-Zahl, sowie deren Ether, vorzugsweise Ethanol, Isopropanol, Propylenglykol, Glycerin, Ethylenglykol, Ethy- lenglykolmonoethyl- oder -monobutylether, Propylenglykolmonomethyl, - monoethyl- oder -monobutylether, Diethylenglykolmonomethyl- oder -mono- ethylether und analoge Produkte.  Alcohols, diols or polyols of low C number, and their ethers, preferably ethanol, isopropanol, propylene glycol, glycerol, ethylene glycol, ethylene glycol monoethyl or monobutyl ether, propylene glycol monomethyl, monoethyl or monobutyl ether, diethylene glycol monomethyl or monoethyl ether and analog products.
Insbesondere werden Gemische der vorstehend genannten Lösungsmittel verwendet. Bei alkoholischen Lösungsmitteln kann Wasser ein weiterer Bestandteil sein. In particular, mixtures of the abovementioned solvents are used. For alcoholic solvents, water can be another ingredient.
Kosmetische Zubereitungen im Sinne der vorliegenden Erfindung können auch als Gele vorliegen, die neben einem wirksamen Gehalt am erfindungsgemäßen Wrk- stoff und dafür üblicherweise verwendeten Lösungsmitteln, bevorzugt Wasser, noch organische Verdickungsmittel, z.B. Gummiarabikum, Xanthangummi, Natrium- alginat, Cellulose-Derivate, vorzugsweise Methylcellulose, Hydroxymethylcellulose, Hydroxyethylcellulose, Hydroxypropylcellulose, Hydroxypropylmethylcellulose oder anorganische Verdickungsmittel, z. B. Aluminiumsilikate wie beispielsweise Ben- tonite, oder ein Gemisch aus Polyethylenglykol und Polyethylenglykolstearat oder - distearat, enthalten. Cosmetic preparations in the sense of the present invention can also be present as gels which, in addition to an effective content of the active substance according to the invention and solvents customarily used for this purpose, preferably water, are still organic thickening agents, for example gum arabic, xanthan gum, sodium alginate, cellulose derivatives, preferably methylcellulose, hydroxymethylcellulose, hydroxyethylcellulose, hydroxypropylcellulose, hydroxypropylmethylcellulose or inorganic thickening agents, e.g. For example, aluminum silicates such as Benetonite, or a mixture of polyethylene glycol and polyethylene glycol stearate or distearate.
Erfindungsgemäß vorteilhafte Ausführungsformen der vorliegenden Erfindung sind dadurch gekennzeichnet, dass die Zubereitung ebenfalls Polyacrylate als Verdickungsmittel enthält. Embodiments of the present invention which are advantageous according to the invention are characterized in that the preparation likewise contains polyacrylates as thickening agent.
Erfindungsgemäß vorteilhafte Polyacrylate sind Polymere der Acrylsäure, insbesondere solche, die aus der Gruppe der sogenannten Carbomere oder Carbopole (Carbopol<(R)> ist eigentlich eine eingetragene Marke der B. F. Goodrich Company) gewählt werden. Vorteilhafte Carbopole sind beispielsweise die Typen 907, 910, 934, 940, 941 , 951 , 954, 980, 981 , 1342, 1382, 2984 und 5984 oder auch die Typen ETD (Easy-to-disperse) 2001 , 2020, 2050, Aqua-SF1 wobei diese Verbindungen einzeln oder in beliebigen Kombinationen untereinander vorliegen können. Polyacrylates which are advantageous according to the invention are polymers of acrylic acid, in particular those selected from the group of the so-called carbomers or carbopols (Carbopol <(R)> is actually a registered trademark of the B.F. Goodrich Company). Advantageous carbopols are for example the types 907, 910, 934, 940, 941, 951, 954, 980, 981, 1342, 1382, 2984 and 5984 or also the types ETD (Easy-to-disperse) 2001, 2020, 2050, Aqua -SF1 wherein these compounds can be present individually or in any desired combinations with one another.
Ferner vorteilhaft im Sinne der vorliegenden Erfindung sind die den Acrylat- Alkylacrylat-Copolymeren vergleichbaren Copolymere aus C10-30-Alkylacrylaten und einem oder mehreren Monomeren der Acrylsäure, der Methacrylsäure oder deren Ester. Die INCI-Bezeichnung für solche Verbindungen ist "Acrylates/C 10-30 Alkyl Acrylate Crosspolymer". Insbesondere vorteilhaft sind die unter den Handelsbezeichnungen Pemulen TR1 und Pemulen TR2 bei der B. F. Goodrich Company erhältlichen. Also advantageous for the purposes of the present invention, the copolymers of C10-30-alkyl acrylates and one or more monomers of acrylic acid, methacrylic acid or their esters which are comparable to the acrylate-alkyl acrylate copolymers are advantageous. The INCI name for such compounds is "Acrylates / C 10-30 Alkyl Acrylate Crosspolymer". Particularly advantageous are those available under the trade names Pemulen TR1 and Pemulen TR2 from the B.F. Goodrich Company.
Es ist erfindungsgemäß von besonderem Vorteil, wenn als Polyacrylate C10 bis C30-Alkylacrylat Copolymere eingesetzt werden.  It is according to the invention of particular advantage when used as polyacrylates C10 to C30-alkyl acrylate copolymers.
Das Verdickungsmittel ist in dem Gel z.B. in einer Menge zwischen 0, 1 und 30 Gew.-%, bevorzugt zwischen 0,5 und 15 Gew.-%, enthalten. The thickener is present in the gel e.g. in an amount between 0, 1 and 30 wt .-%, preferably between 0.5 and 15 wt .-%, included.
Es folgen vorteilhafte Ausführungsbeispiele der vorliegenden Erfindung. verwendete Rohstoffe Following are advantageous embodiments of the present invention. used raw materials
Handelsname Bezeichnung Aktivgehalt HerstellerTrade name Name Active content Manufacturer
Atlas G-4280 PEG-80 Sorbitanlaurat -75% CrodaAtlas G-4280 PEG-80 sorbitan laurate -75% Croda
Carbopol Aqua Acrylatcopolmyer -30% Lubrizol SF-1 Carbopol Aqua acrylate copolymer -30% Lubrizol SF-1
Carbopol 980 Carbomer 100% Lubrizol Carbopol 980 Carbomer 100% Lubrizole
Cetiol HE PEG-7 Glycerylcocoat 100% CognisCetiol HE PEG-7 glyceryl cocoate 100% Cognis
Cosmospheres Mannitol + Microkristalline 73,75% 25% Pelletech BMM-M Cellulose + Milchsäure + Cl + 1 % + Cl Cosmospheres Mannitol + Microcrystalline 73.75% 25% Pelletech BMM-M Cellulose + Lactic Acid + Cl + 1% + Cl
74160 74160  74160 74160
Cosmospheres Lactose + mikrokristalline 75% + 25% Pelletech WTS-M Cellulose  Cosmospheres lactose + microcrystalline 75% + 25% Pelletech WTS-M cellulose
Eumulgin HRE 40 PEG-40 Hydriertes Rizinusöl 100% Cognis Eumulgin HRE 40 PEG-40 Hydrogenated castor oil 100% Cognis
Euperlan PK 771 Natriumlaurethsulfat + Gly- 25% + 15% + Cognis Euperlan PK 771 sodium laureth sulfate + Gly- 25% + 15% + Cognis
coldistearat + Laureth-10 5%  cold stearate + laureth-10 5%
Euperlan PK 900 PEG-3 Distearat + Natrium25% + 14% Cognis  Euperlan PK 900 PEG-3 Distearate + Sodium 25% + 14% Cognis
laurethsulfat  laureth
Glucamate DOE- PEG-120 100% Lubrizol 120 Methylglucosedioleat  Glucamate DOE-PEG-120 100% Lubrizol 120 methyl glucose dioleate
Hostapon CT PasNatriummethylcocoyltaurat -30% Clariant te  Hostapon CT Pas sodium methyl cocoyl taurate -30% Clariant te
Inducos NO. 13/3 Polyethylen 100% Induchem Induco's NO. 13/3 Polyethylene 100% Induchem
Inducos 14/1 Polyethylen 100% InduchemInducos 14/1 Polyethylene 100% Induchem
Keltrol CG-RD Xanthangummi 100% Cp KelcoKeltrol CG-RD xanthan gum 100% Cp Kelco
Lamesoft PO 65 Coco Glucosid + Glycerylo- 40% + 30% Cognis Lamesoft PO 65 Coco Glucoside + Glyceryl- 40% + 30% Cognis
leat  leat
Merquat 550 Polyquaternium-7 -8% Nalco Merquat 550 Polyquaternium-7 -8% Nalco
Opulyn 301 Styrol/Acrylatcopolymer -40% Rohm & HaasOpulyn 301 styrene / acrylate copolymer -40% Rohm & Haas
Oxetal VD 92 PEG-90 Glycerylisostearat + 70% + 7% Zschimmer & Oxetal VD 92 PEG-90 Glyceryl isostearate + 70% + 7% Zschimmer &
Laureth-2 Schwarz Laureth-2 Black
Plantacare 1200 Laurylglucosid -50% Cognis UP Plantacare 1200 laurylglucoside -50% Cognis UP
Plantacare 2000 Decylglucosid -50% Cognis UP Handelsname Bezeichnung Aktivgehalt HerstellerPlantacare 2000 decylglucoside -50% Cognis UP Trade name Name Active content Manufacturer
Polyox WSR-301 PEG-90M -95% Dow ChemicalPolyox WSR-301 PEG-90M -95% Dow Chemical
Purasal S/PF 50 Natriumlactat -50% Purac Purasal S / PF 50 Sodium lactate -50% Purac
Rewoderm LI 520- PEG-200 Hydriertes -70% Evonik Gold70 Glycerylpalmat schmidt Rewoderm LI 520- PEG-200 Hydrogenated -70% Evonik Gold70 Glyceryl palmitte schmidt
Rewopol SB CS Dinatrium PEG-5 Laurylcitrat -30% Evonik Gold50 Sulfosuccinat schmidtRewopol SB CS disodium PEG-5 lauryl citrate -30% Evonik Gold50 sulfosuccinate schmidt
Rewoteric AM C Natriumcocoamphoacetat -90% Evonik GoldschmidtRewoteric AM C Sodium cocoamphoacetate -90% Evonik Goldschmidt
Tego Betain F 50 Cocamidopropylbetain + Gly- -36% + -3% Evonik Goldcerin schmidtTego Betain F 50 Cocamidopropylbetaine + Gly- 36% + -3% Evonik Goldcerin schmidt
Texapon N 70 Natriumlaurylethersulfat -70% CognisTexapon N 70 sodium lauryl ether sulfate -70% Cognis
Texapon K 14 S Natriummyristylethersulfat -70% Cognis Spezial Texapon K 14 S sodium myristyl ether sulfate -70% Cognis Spezial
Ucare Polymer JR Polyquaternium-10 -90% Dow Chemical 400  Ucare Polymer JR Polyquaternium-10 -90% Dow Chemical 400
Unispheres UE- Lactose + Cellulose + Cl 68,5% + Induchem 507 77007 + Hydroxypropyl Me- 24,5% + 3%  Unispheres UE lactose + cellulose + Cl 68.5% + Induchem 507 77007 + Hydroxypropyl Me- 24.5% + 3%
thylcellulose + Vitamin-E- + 3% + 1 % Acetate  cellulose + vitamin E + 3% + 1% acetates
Uvinul MS-40 Benzophenon-4 100% BASF Uvinul MS-40 Benzophenone-4 100% BASF
Vergleichsversuch Duschgel Comparative experiment shower gel
Folgende Produkte wurden hergestellt und in einem Probandentest miteinander verglichen:  The following products were manufactured and compared in a test subject:
alle Konzentrationsangaben in Gew.-%  all concentration data in% by weight
* Menge variabel zur Einstellung eines pH-Wertes von 4,8 bis 5,3  * Variable amount for setting a pH of 4.8 to 5.3
** Menge variabel zur Einstellung einer Viskosität im Bereich von 3000 - 5000 mPas (gemssen mit HAAKE viscotester VT02 mit Rotor 1)  ** Quantity variable for setting a viscosity in the range of 3000 - 5000 mPas (measured with HAAKE viscotester VT02 with rotor 1)
Herstellung manufacturing
Die Inhaltsstoffe der Phase A werden vermischt, bis eine homogene Phase entsteht.  The ingredients of phase A are mixed until a homogeneous phase is obtained.
Eumulgin HRE 40 wird bei einer Temperatur von ca. 40°C aufgeschmolzen. Die übrigen Rohstoffe der Phase B werden zum Eumulgin HRE 40 gegeben. Die Phase wird homogen vermischt und zur Phase A gegeben. Eumulgin HRE 40 is melted at a temperature of about 40 ° C. The remaining Phase B raw materials are added to the Eumulgin HRE 40. The phase is mixed homogeneously and added to phase A.
Die Zugabe der Inhaltsstoffe der Phase C erfolgt unter Rühren in der angegebenen Reihenfolge. Beide Duschgele haben einen L/D-Wert von ca. 1 ,5. The addition of the ingredients of phase C is carried out with stirring in the order given. Both shower gels have an L / D value of approx. 1.5.
Ergebnisse Results
7 von 9 Probanden beurteilten die Sensorik des erfinderischen Produktes A insgesamt besser als die Sensorik des Vergleichsproduktes B. Die übrigen Probanden konnten keinen Unterschied feststellen. 7 out of 9 subjects rated the sensor technology of the inventive product A better overall than the sensors of the comparative product B. The other subjects could not detect a difference.
Es ist deutlich zu erkennen, dass das erfinderische Produkt A bezüglich aller Merkmale dem Vergleichsprodukt deutlich überlegen ist. It can be clearly seen that the inventive product A is clearly superior to the comparison product with respect to all features.
Vergleichsversuch Gesichtsreiniger Comparative experiment facial cleanser
Folgende Produkte wurden hergestellt und in einem Probandentest miteinander verglichen:  The following products were manufactured and compared in a test subject:
alle Konzentrationsangaben in Gew.-%  all concentration data in% by weight
* Menge variabel zur Einstellung eines pH-Wertes von 6,2 bis 6,8  * Variable amount for setting a pH of 6.2 to 6.8
Herstellung manufacturing
Die Inhalststoffe der Phase A mit dem Index 1 werden miteinander vermischt, bis eine homogene Phase entsteht. Die übrigens Inhaltsstoffe der Phase A werden in der angegebenen Reihenfolge zugegeben. Carbopol Aqua SF-1 wird vor der Zugabe filtriert. Es wird gerührt, bis eine klare Phase entstanden ist. Eumulgin HRE 40 wird bei einer Temperatur von ca. 40°C aufgeschmolzen. Die übrigen Rohstoffe der Phase B werden zum Eumulgin HRE 40 gegeben. Die Phase wird homogen vermischt und zur Phase A gegeben. The Inhalants of Phase A Index 1 are mixed together until a homogeneous phase is obtained. The remaining ingredients of phase A are added in the order listed. Carbopol Aqua SF-1 is filtered before addition. It is stirred until a clear phase has emerged. Eumulgin HRE 40 is melted at a temperature of about 40 ° C. The remaining Phase B raw materials are added to the Eumulgin HRE 40. The phase is mixed homogeneously and added to phase A.
Ucare Polymer JR 400 wird in das Wasser der Phase C eingestreut. Die Phase C wird unter Rühren auf ca. 70°C erwärmt bis eine klare Lösung entsteht. Phase C wird gekühlt und zur Phase A gegeben. Ucare Polymer JR 400 is sprinkled into the water of phase C. The phase C is heated with stirring to about 70 ° C until a clear solution is formed. Phase C is cooled and added to Phase A.
Die Inhalststoffe der Phase D werden in der angegebenen Reihenfolge zugegeben. Nach Zugabe der Cosmospheres erfolgt eine vorsichtige Durchmischung der Formulierung. The Inhalants of Phase D are added in the order listed. After addition of the cosmospheres, careful mixing of the formulation takes place.
Beide Gesichtsreiniger haben einen L/D-Wert von ca. 20. Both facial cleaners have an L / D value of about 20.
Ergebnisse Results
4 von 8 Probanden empfanden das Hautgefühl des erfinderischen Produktes A als weniger schmierig-glitschig als das Hautgefühl des Vergleichsproduktes B. Die übrigen Probanden konnten keinen Unterschied feststellen. 4 out of 8 subjects found the skin feel of the inventive product A to be less greasy-slippery than the skin feel of the comparative product B. The other subjects could not detect any difference.
Es ist deutlich zu erkennen, dass das erfinderische Produkt A bezüglich aller Merkmale dem Vergleichsprodukt deutlich überlegen ist. Beispielrezepturen It can be clearly seen that the inventive product A is clearly superior to the comparison product with respect to all features. example recipes
Shampoozubereitungen  shampoo preparations
alle Konzentrationsangaben in Gew.-%  all concentration data in% by weight
* Menge variabel zur Einstellung einer Viskosität im Bereich von 3000 - 4500 mPas * Quantity variable for setting a viscosity in the range of 3000 - 4500 mPas
(gemssen mit HAAKE viscotester VT02 mit Rotor 1) (according to HAAKE viscotester VT02 with rotor 1)
** Menge variabel zur Einstellung eines pH-Wertes von 4,8 bis 5,8  ** Quantity variable to set a pH of 4.8 to 5.8
Die Zubereitungen haben einen L/D- Wert von ca. 10. The preparations have an L / D value of approx. 10.
Die Inhalststoffe der Phase A werden miteinander vermischt, bis eine homogene Phase entsteht. Ucare Polymer JR 400 wird in das Wasser der Phase B eingestreut. Die Phase B wird unter Rühren auf ca. 70°C erwärmt bis eine klare Lösung entsteht. Phase B wird gekühlt und zur Phase A gegeben. The Inhalststoffe of phase A are mixed together until a homogeneous phase is formed. Ucare Polymer JR 400 is interspersed in the water of phase B. The phase B is heated with stirring to about 70 ° C until a clear solution is formed. Phase B is cooled and added to Phase A.
Eumulgin HRE 40 wird bei einer Temperatur von ca. 40°C aufgeschmolzen. Das Parfüm wird zum Eumulgin HRE 40 gegeben. Die Phase wird homogen vermischt und zur Phase A gegeben. Eumulgin HRE 40 is melted at a temperature of about 40 ° C. The perfume is given to Eumulgin HRE 40. The phase is mixed homogeneously and added to phase A.
Die Zugabe der Inhaltsstoffe der Phase D erfolgt in der angegebenen Reihenfolge. Es wird gerührt bis eine homogenes Shampoo entsteht. The addition of the ingredients of phase D is carried out in the order given. It is stirred until a homogeneous shampoo is formed.
Duschgelzubereitungen shower gel preparations
alle Konzentrationsangaben in Gew.-%  all concentration data in% by weight
* Menge variabel zur Einstellung eines pH-Wertes von 4,8 bis 5,3  * Variable amount for setting a pH of 4.8 to 5.3
** Menge variabel zur Einstellung einer Viskosität im Bereich von 3000 - 5000 mPas (gemssen mit HAAKE viscotester VT02 mit Rotor 1 ) Die Inhaltsstoffe der Phase A werden vermischt, bis eine homogene Mischung entsteht. ** Quantity variable for setting a viscosity in the range of 3000 - 5000 mPas (measured with HAAKE viscotester VT02 with rotor 1) The ingredients of phase A are mixed until a homogeneous mixture is obtained.
Ucare Polymer JR 400 wird in das Wasser der Phase B eingestreut. Die Phase B wird unter Rühren auf ca. 70°C erwärmt bis eine klare Lösung entsteht. Phase B wird gekühlt und zur Phase A gegeben. Ucare Polymer JR 400 is interspersed in the water of phase B. The phase B is heated with stirring to about 70 ° C until a clear solution is formed. Phase B is cooled and added to Phase A.
Eumulgin HRE 40 wird bei einer Temperatur von ca. 40°C aufgeschmolzen. Die übrigen Rohstoffe der Phase C werden zum Eumulgin HRE 40 gegeben. Die Phase wird homogen vermischt und zur Phase A gegeben. Eumulgin HRE 40 is melted at a temperature of about 40 ° C. The remaining Phase C raw materials are added to the Eumulgin HRE 40. The phase is mixed homogeneously and added to phase A.
Die Zugabe der Inhaltsstoffe der Phase D erfolgt unter Rühren in der angegebenen Reihenfolge. The addition of the ingredients of phase D is carried out with stirring in the order given.
Die Zubereitungen 2.1 bis 2.4 haben einen L/D-Wert von ca. 2. Die Zubereitung 2.5 hat einen L/D-Wert von ca. 5. The preparations 2.1 to 2.4 have an L / D value of about 2. The preparation 2.5 has an L / D value of about 5.
Gesichtsreinigerzubereitungen Facial cleanser preparations
alle Konzentrationsangaben in Gew.-%  all concentration data in% by weight
* Menge variabel zur Einstellung eines pH-Wertes von 6,2 bis 6,8  * Variable amount for setting a pH of 6.2 to 6.8
Die Inhalststoffe der Phase A mit dem Index 1 werden miteinander vermischt, bis eine homogene Phase entsteht. Die übrigens Inhaltsstoffe der Phase A werden in der angegebenen Reihenfolge zugegeben. Carbopol Aqua SF-1 wird vor der Zugabe filtriert. Es wird gerührt, bis eine klare Phase entstanden ist. Eumulgin HRE 40 wird bei einer Temperatur von ca. 40°C aufgeschmolzen. Die übrigen Rohstoffe der Phase B werden zum Eumulgin HRE 40 gegeben. Die Phase wird homogen vermischt und zur Phase A gegeben. The Inhalants of Phase A Index 1 are mixed together until a homogeneous phase is obtained. The remaining ingredients of phase A are added in the order listed. Carbopol Aqua SF-1 is filtered before addition. It is stirred until a clear phase has emerged. Eumulgin HRE 40 is melted at a temperature of about 40 ° C. The remaining Phase B raw materials are added to the Eumulgin HRE 40. The phase is mixed homogeneously and added to phase A.
Ucare Polymer JR 400 wird in das Wasser der Phase C eingestreut. Die Phase C wird unter Rühren auf ca. 70°C erwärmt bis eine klare Lösung entsteht. Phase C wird gekühlt und zur Phase A gegeben. Ucare Polymer JR 400 is sprinkled into the water of phase C. The phase C is heated with stirring to about 70 ° C until a clear solution is formed. Phase C is cooled and added to Phase A.
Die Inhalststoffe der Phase D werden in der angegebenen Reihenfolge zugegeben. Nach Zugabe der Cosmospheres erfolgt eine vorsichtige Durchmischung der Formulierung. The Inhalants of Phase D are added in the order listed. After addition of the cosmospheres, careful mixing of the formulation takes place.
Die Zubereitungen haben einen L/D-Wert von ca. 20. The preparations have an L / D value of about 20.
Phase INCI 3.4 3.5 3.6 Phase INCI 3.4 3.5 3.6
A Wasser VES ad 100 ad 100 ad 100  A water VES ad 100 ad 100 ad 100
A Carbopol 980 1.20 1.00 1.50  A Carbopol 980 1.20 1.00 1.50
A Keltrol CG-RD 0.25 0.50 0.20  A Keltrol CG-RD 0.25 0.50 0.20
B Texapon N70 2.00 2.00 2.00  B Texapon N70 2.00 2.00 2.00
B Plantacare 2000 UP 0.50 0.50 0.50  B Plantacare 2000 UP 0.50 0.50 0.50
B Glycerin 1.00 - - B glycerin 1.00 - -
B Glycerylglucosid 1.00 1.00 1.00 B glyceryl glucoside 1.00 1.00 1.00
C Cetiol HE 0.50 0.50 0.50  C Cetiol HE 0.50 0.50 0.50
C Parfüm 0.10 0.10 0.15  C Perfume 0.10 0.10 0.15
C Vitami n-E-Acetat 0.06 - - C Vitami n-E acetate 0.06 - -
C Magnolienextrakt - 0.001 -C magnolia extract - 0.001 -
C Methylparaben 0.10 0.10 0.10 C methyl paraben 0.10 0.10 0.10
C Ethylparaben 0.10 0.10 0.10  C Ethyl paraben 0.10 0.10 0.10
C Phenoxyethanol 0.70 0.70 - C Phenoxyethanol 0.70 0.70 -
D Cl 42090 0.0002 0.0001 0.0002 D Cl 42090 0.0002 0.0001 0.0002
D Cl 47005 - - 0.003  D Cl 47005 - - 0.003
D Cl 16035 0.0002 - - D Cl 16035 0.0002 - -
D Hostapon CT Paste 1.80 1.80 1.80 D Hostapon CT Paste 1.80 1.80 1.80
D Lotusextrakt 0.10 - - D lotus extract 0.10 - -
D Panthenol 0.10 - -D Panthenol 0.10 - -
D Uvinul MS-40 0.05 0.05 0.05 D Uvinul MS-40 0.05 0.05 0.05
D Wasser VES 10.00 10.00 10.00  D water VES 10.00 10.00 10.00
E1 Natronlauge 45%ig * 0.90 0.90 0.90  E1 sodium hydroxide solution 45% * 0.90 0.90 0.90
E2 Unispheres UE-507 - - 0.20  E2 Unispheres UE-507 - - 0.20
E3 Inducos NO. 13/3 - - 1.20  E3 Inducos NO. 13/3 - - 1.20
* Menge variabel zur Einstellung eines pH-Wertes von 6,2 bis 6,8  * Variable amount for setting a pH of 6.2 to 6.8
Das Carbopol 980 wird in das Wasser der Phase A eingestreut und mit einem Zauberstab homogen dispergiert. Anschließend wird Keltrol CG-RD zugefügt und gerührt, bis eine homogene Phase entsteht. The Carbopol 980 is sprinkled into the water of phase A and dispersed homogeneously with a magic wand. Then Keltrol CG-RD is added and stirred until a homogeneous phase is obtained.
Die Rohstoffe der Phase B werden miteinander gemischt und gerührt, bis eine homogene Phase entsteht. Phase B wird zu Phase A gegeben. Die Rohstoffe der Phase C ohne das Parfüm werden gemischt und unter Rühren auf 50°C erwärmt, bis eine homogene Phase entsteht. Die Mischung wird abgekühlt und das Parfüm wird zugegeben. Phase C wird zur Phase A gegeben. The raw materials of phase B are mixed together and stirred until a homogeneous phase is obtained. Phase B is added to Phase A. The raw materials of phase C without the perfume are mixed and heated with stirring to 50 ° C until a homogeneous phase is formed. The mixture is cooled and the perfume is added. Phase C is added to Phase A.
Das Wasser der Phase D und Hostapon CT Paste werden unter Rühren auf 50°C erwärmt. Es wird gerührt, bis Hostapon CT Paste gelöst ist. Anschließend werden die übrigen Rohstoffe der Phase D zugegeben. Es wird gerührt, bis eine homogene Phase entsteht. Phase D wird zur Phase A gegeben. The water of phase D and Hostapon CT paste are heated to 50 ° C. with stirring. It is stirred until Hostapon CT Paste is dissolved. Subsequently, the remaining raw materials of phase D are added. It is stirred until a homogeneous phase is formed. Phase D is added to phase A.
Die Inhalststoffe der Phase E werden in der angegebenen Reihenfolge zugegeben. Nach Zugabe der Natronlauge erfolgt nur noch eine vorsichtige Durchmischung der Formulierung. The Inhalants of Phase E are added in the order listed. After addition of the sodium hydroxide solution, only careful mixing of the formulation takes place.
Die Zubereitungen haben einen L/D-Wert von ca. 20. The preparations have an L / D value of about 20.

Claims

Patentansprüche: claims:
1. Wirkstoffkombinationen aus 1. drug combinations from
(i) einem oder mehreren milden Tensiden  (i) one or more mild surfactants
und and
(ii) einem oder mehreren Glucosylglyceriden.  (ii) one or more glucosylglycerides.
2. Wirkstoffkombinationen nach Anspruch 1 , in denen das molare Verhältnis von einem oder mehreren sauren Konservierungsmitteln aus dem Bereich von 100 : 1 bis 1 : 1000, bevorzugt 50 : 1 bis 1 : 500, insbesondere bevorzugt 20 : 1 bis 1 : 200 gewählt wird. 2. Active ingredient combinations according to claim 1, in which the molar ratio of one or more acidic preservatives from the range of 100: 1 to 1: 1000, preferably 50: 1 to 1: 500, particularly preferably 20: 1 to 1: 200 is selected ,
3. Wirkstoffkombinationen nach Anspruch 1 , dadurch gekennzeichnet, dass das oder die milden Tenside ausgewählt sind aus Alkylpolyglucosiden, bevorzugt Laurylglucosid und Decylglucosid, Betaintensiden, bevorzugt Cocamidopropylbetain oder Cocobetain, Aminosäuretensiden, bevorzugt Natriumlauroylglutamat und Dinatriumcocoylglutamat und ethoxylierten Glyceriden, bevorzugt PEG-7 Glycerylcocoat. 3. active compound combinations according to claim 1, characterized in that the one or more mild surfactants are selected from alkylpolyglucosides, preferably laurylglucoside and decylglucoside, Betaintensiden, preferably Cocamidopropylbetain or Cocobetain, Aminosäuretensiden, preferably sodium lauroylglutamate and disodium cocoylglutamate and ethoxylated glycerides, preferably PEG-7 glycerylcocoate.
4. Kosmetische Zubereitungen, Wrkstoffkombinationen gemäß einem der Ansprüche 1 - 3 enthaltend. 4. Cosmetic preparations, active substance combinations according to one of claims 1 - 3 containing.
5. Kosmetische Zubereitungen gemäß Anspruch 4 in denen das oder die Glucosylglyceride in der Wasser- und/oder Ölphase in Konzentrationen von 0,001 - 40,00 Gew.-%, bevorzugt 0,005 - 15,00 Gew.-%, besonders bevorzugt 0,01 - 12,00 Gew.-%, jeweils bezogen auf das Gesamtgewicht der Zusammensetzung, vorliegen. 5. Cosmetic preparations according to claim 4, in which the glucosylglycerides in the water and / or oil phase are present in concentrations of 0.001-40.00 wt.%, Preferably 0.005-15.00 wt.%, Particularly preferably 0.01 - 12.00 wt .-%, each based on the total weight of the composition.
6. Kosmetische Zubereitungen gemäß Anspruch 4 oder 5, in denen das oder die milden Tenside ausgewählt sind aus Alkylpolyglucosiden, bevorzugt Laurylglucosid und Decylglucosid, Betaintensiden, bevorzugt Cocamidopropylbetain oder Cocobetain, Aminosäuretensiden, bevorzugt Natriumlauroylglutamat und Dinatriumcocoylglutamat und ethoxylierten Glyceriden, bevorzugt PEG-7 Glycerylcocoat. Cosmetic preparations according to claim 4 or 5, in which the mild surfactant or surfactants are selected from alkyl polyglucosides, preferably lauryl glucoside and decyl glucoside, betaine surfactants, preferably cocamidopropyl betaine or coco betaine, amino acid surfactants, preferably sodium lauroyl glutamate and disodium cocoyl glutamate and ethoxylated glycerides, preferably PEG-7 glyceryl cocoate.
7. Verwendung von Zubereitungen nach einem der vorstehenden Ansprüchen als waschaktive Zubereitungen. 7. Use of preparations according to one of the preceding claims as washing-active preparations.
EP11790950.7A 2010-12-23 2011-11-29 Active ingredient combinations of glyceryl glucosides and one or more mild surfactants Ceased EP2654705A2 (en)

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DE102010055767A DE102010055767A1 (en) 2010-12-23 2010-12-23 Drug combinations of glucosylglycerides and one or more mild surfactants
PCT/EP2011/071227 WO2012084423A2 (en) 2010-12-23 2011-11-29 Active ingredient combinations of glyceryl glucosides and one or more mild surfactants

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WO2018058207A1 (en) * 2016-09-30 2018-04-05 L'oreal Hair treatment compositions comprising thiol-based compounds
JP7055133B2 (en) * 2016-09-30 2022-04-15 ロレアル Hair cosmetic compositions containing thiol compounds, as well as methods for cleansing and treating hair.
CN108078803A (en) * 2017-12-01 2018-05-29 上海莎伦巍化学科技有限公司 A kind of mild shower cream of deeply preserving moisture and preparation method thereof
DE102019204971A1 (en) * 2019-04-08 2020-10-08 Henkel Ag & Co. Kgaa Shampoo for more hair volume
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EP3409266A1 (en) 2018-12-05
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WO2012084423A3 (en) 2013-07-18

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