EP2599721B1 - Machine d'emballage pour conditionnement sans germe et method correspondante - Google Patents

Machine d'emballage pour conditionnement sans germe et method correspondante Download PDF

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Publication number
EP2599721B1
EP2599721B1 EP12194710.5A EP12194710A EP2599721B1 EP 2599721 B1 EP2599721 B1 EP 2599721B1 EP 12194710 A EP12194710 A EP 12194710A EP 2599721 B1 EP2599721 B1 EP 2599721B1
Authority
EP
European Patent Office
Prior art keywords
transport
transport container
station
filling
sterile
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Not-in-force
Application number
EP12194710.5A
Other languages
German (de)
English (en)
Other versions
EP2599721A3 (fr
EP2599721A2 (fr
Inventor
Gerhard Schubert
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Gerhard Schubert GmbH
Original Assignee
Gerhard Schubert GmbH
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Gerhard Schubert GmbH filed Critical Gerhard Schubert GmbH
Publication of EP2599721A2 publication Critical patent/EP2599721A2/fr
Publication of EP2599721A3 publication Critical patent/EP2599721A3/fr
Application granted granted Critical
Publication of EP2599721B1 publication Critical patent/EP2599721B1/fr
Not-in-force legal-status Critical Current
Anticipated expiration legal-status Critical

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Classifications

    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B65—CONVEYING; PACKING; STORING; HANDLING THIN OR FILAMENTARY MATERIAL
    • B65B—MACHINES, APPARATUS OR DEVICES FOR, OR METHODS OF, PACKAGING ARTICLES OR MATERIALS; UNPACKING
    • B65B35/00—Supplying, feeding, arranging or orientating articles to be packaged
    • B65B35/10—Feeding, e.g. conveying, single articles
    • B65B35/16—Feeding, e.g. conveying, single articles by grippers
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B65—CONVEYING; PACKING; STORING; HANDLING THIN OR FILAMENTARY MATERIAL
    • B65B—MACHINES, APPARATUS OR DEVICES FOR, OR METHODS OF, PACKAGING ARTICLES OR MATERIALS; UNPACKING
    • B65B3/00—Packaging plastic material, semiliquids, liquids or mixed solids and liquids, in individual containers or receptacles, e.g. bags, sacks, boxes, cartons, cans, or jars
    • B65B3/04—Methods of, or means for, filling the material into the containers or receptacles
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B65—CONVEYING; PACKING; STORING; HANDLING THIN OR FILAMENTARY MATERIAL
    • B65B—MACHINES, APPARATUS OR DEVICES FOR, OR METHODS OF, PACKAGING ARTICLES OR MATERIALS; UNPACKING
    • B65B55/00—Preserving, protecting or purifying packages or package contents in association with packaging
    • B65B55/02—Sterilising, e.g. of complete packages
    • B65B55/027—Packaging in aseptic chambers
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B65—CONVEYING; PACKING; STORING; HANDLING THIN OR FILAMENTARY MATERIAL
    • B65B—MACHINES, APPARATUS OR DEVICES FOR, OR METHODS OF, PACKAGING ARTICLES OR MATERIALS; UNPACKING
    • B65B55/00—Preserving, protecting or purifying packages or package contents in association with packaging
    • B65B55/24—Cleaning of, or removing dust from, containers, wrappers, or packaging ; Preventing of fouling
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B65—CONVEYING; PACKING; STORING; HANDLING THIN OR FILAMENTARY MATERIAL
    • B65B—MACHINES, APPARATUS OR DEVICES FOR, OR METHODS OF, PACKAGING ARTICLES OR MATERIALS; UNPACKING
    • B65B65/00—Details peculiar to packaging machines and not otherwise provided for; Arrangements of such details
    • B65B65/003—Packaging lines, e.g. general layout
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B65—CONVEYING; PACKING; STORING; HANDLING THIN OR FILAMENTARY MATERIAL
    • B65B—MACHINES, APPARATUS OR DEVICES FOR, OR METHODS OF, PACKAGING ARTICLES OR MATERIALS; UNPACKING
    • B65B2220/00—Specific aspects of the packaging operation
    • B65B2220/16—Packaging contents into primary and secondary packaging
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B65—CONVEYING; PACKING; STORING; HANDLING THIN OR FILAMENTARY MATERIAL
    • B65B—MACHINES, APPARATUS OR DEVICES FOR, OR METHODS OF, PACKAGING ARTICLES OR MATERIALS; UNPACKING
    • B65B3/00—Packaging plastic material, semiliquids, liquids or mixed solids and liquids, in individual containers or receptacles, e.g. bags, sacks, boxes, cartons, cans, or jars
    • B65B3/003—Filling medical containers such as ampoules, vials, syringes or the like
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B65—CONVEYING; PACKING; STORING; HANDLING THIN OR FILAMENTARY MATERIAL
    • B65B—MACHINES, APPARATUS OR DEVICES FOR, OR METHODS OF, PACKAGING ARTICLES OR MATERIALS; UNPACKING
    • B65B55/00—Preserving, protecting or purifying packages or package contents in association with packaging
    • B65B55/02—Sterilising, e.g. of complete packages
    • B65B55/04—Sterilising wrappers or receptacles prior to, or during, packaging
    • B65B55/10—Sterilising wrappers or receptacles prior to, or during, packaging by liquids or gases
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B65—CONVEYING; PACKING; STORING; HANDLING THIN OR FILAMENTARY MATERIAL
    • B65B—MACHINES, APPARATUS OR DEVICES FOR, OR METHODS OF, PACKAGING ARTICLES OR MATERIALS; UNPACKING
    • B65B7/00—Closing containers or receptacles after filling
    • B65B7/16—Closing semi-rigid or rigid containers or receptacles not deformed by, or not taking-up shape of, contents, e.g. boxes or cartons
    • B65B7/161—Sealing filled ampoules

Definitions

  • the invention relates to a packaging machine for germ-free packaging.
  • Such packaging machines for a germ-free packaging in Clearverpackungen product must ensure that both the Clearverpackung - for example, a syringe body, a bottle or a tube - as well as the product to be introduced into it - usually a liquid - either germ-free or prepared before packaging a germ-free Reach state, and bottled in this and germ-proof.
  • Such a machine is from the WO 2004/076288 known.
  • the term “germ-free” is understood to mean the degree of sterility desired by the respective user, and the term “sterilizing” is understood to mean the process for achieving this level of sterility.
  • the first packaging which is generally not germ-free, has been brought into a sterilization station after introduction into the packaging machine and, if appropriate, insertion into a transport container or an outer packaging, and subsequently sterilized within the sterile room of the sterilization station Primary packaging filled and this closed. Since this is usually done on separate successively arranged workstations, the sterile room that surrounds all these stations, relatively large dimensions, and above all it is penetrated by a large number of poorly accessible and complicated to be cleaned components, such as conveyors, ducts in the form of cables and hoses, joints, passports etc.
  • a typical case of a production process therefore looks like that the packaging machine is in continuous use and then a cleaning is necessary, which takes at least a full shift.
  • a transport container for ampoules to be filled with medicaments the open top side of which is tightly sealable with a film that is impermeable to germs, but permeable to a sterilizing gas, so that the transport container thus sealed is sterilized by introducing it into an atmosphere of this gas can.
  • the transport container Especially if only the interior of the transport container is kept sterile inside the transport container but after sterilization several steps, such as filling and closing must be performed, which usually take place at separate workstations, the transport container must be germ-tight closed and for performing these steps can be reopened for a limited period of time in a germ-proof environment produced there.
  • the transport containers can be supplied to a plurality of sequential or parallel sterilizing stations, where they are then sterilized for more than one cycle time.
  • Buffering of the arriving transport containers before and / or behind the sterilization stations is also possible for this purpose.
  • the sterilization of the interior of the transport container - which are generally formed trough-shaped with closable top - is preferably carried out by tightly connecting to a sterilizer, for example a patch from above on the trough-shaped transport container sterilization hood.
  • the germ-proof closure, for example a cover, of the transport container must be designed so that it can be opened after the tight connection of the sterilization device, for example the sterilization hood, and can also be closed again.
  • the sterility of the interior of the closed transport container can be facilitated by the interior of the transport container is kept under pressure.
  • the filling and sealing is carried out in the same work station, preferably by the same tool.
  • one of the tools which is to be sterile for example the filling tool or the closing tool, is to be sterilized during the operation of the machine, these tools can be present redundantly, so that one is sterilized while the other is in use.
  • this space will usually not only have to contain the transport container, but also the carriage carrying it. If this carriage is movable along a guideway and / or a track body, this guideway and this track body.
  • the carriage with the transport container preferably passes over at the transition from the non-sterile to the sterile area and vice versa in each case a gap in the guideway and in particular in the guideway bearing track body, so arranged in the gap of the guideway or the track body a bulkhead of the sterile room can be, which can be completely closed until the carriage is retracted with the transport container across the gap in the example lock chamber from the non-sterile space.
  • the plastic tubes are usually filled upside down, ie the closure, filled with the rear end open and then the rear end sealed.
  • the packaging machine according to the invention for carrying out this procedure thus comprises a transport device for linking the workstations of this packaging machine with movable carriages carrying, for example, a transport container into which the open and to be filled primary packs are inserted in a defined position, and at least one sterilization station for sterilization the transport container, in particular together with the empty primary packaging inserted therein.
  • the tools of the other stations which are to work sterile on the primary packaging, in particular the filling tool and the closing tool, must be equipped with a sterilization device which can be connected tightly to the transport containers, so that the filling and sealing can take place under sterile conditions ,
  • the transport container has a germ-tight closing device, in particular on its upper side, which is designed in particular so that it in the open state, the placement of the sterilizer not hindered and in particular can be opened and closed when attached sterilizer.
  • the moving components of the transport container in particular its cover, can be moved without contact from the outside, ie from the carriage or the tool acting on the transport container, for example by means of magnetic force.
  • the interior of the transport container can be kept under an overpressure, possibly even under a negative pressure.
  • an overpressure can be generated either by closing the transport container by means of a movable into the transport container in dense membrane, or by the transport container is acted upon by the carriage with pressure, but preferably not by pumped and purified ambient air, but by pumping a germ-free Inertgases, which is stored in a pressure vessel as an overpressure source in the carriage.
  • Both the sterilization station and the sterile working tools preferably have a hood which can be placed on the transport containers in a manner that is shaped and dimensioned in cooperation with the transport container such that the closing device of the transport container only after the hood has been sealed and sterilizes the outside of this closing device the closure device is opened and the interior of the transport container for processing by the tool - for example, the filling tool or closing tool - is accessible.
  • the filling tool additionally contains a closing tool for the filled primary packaging, so that both working steps can be carried out together in one and the same working position and in the same sterilized room.
  • the space around the entire transport container around has the guideways having web body of the transport device on a gap at the transition between the non-sterile and the sterile space in which a is tightly closable sterile bulkhead, which is only opened to pass a carriage with a transport container.
  • the Figure 1c shows first the trough-shaped transport container 20 in a sectional view, which has four circumferential, drawn up to about the same height side walls and in which already to be filled primary packaging, here in the form of bottles 1, are used.
  • the bottles 1 can be used at predetermined positions in the transport container 20 , a grid grid 27 is inserted into these - preferably form-fitting - which has custom-fit openings for inserting the bottle 1 .
  • the closure caps 22 may also already be stored for later closing of the bottles 1 .
  • the open top of the transport container 20 can be sealed germ-tight by means of a one-piece or multi-part, such as hinged to the transport container 20 , container lid 23 .
  • the transport container 20 sit - usually positioned positively - on a respective carriage 9 a transport device 8 , which can be moved along the guide rail 18 a of a sheet body 18 through the machine.
  • FIGS. 1a and b show - in already inserted bottles 1 in the transport container 20 - each also germ-tight placed on the transport container 20 hood 13, which may be differently equipped inside, but serves in both cases the purpose that the interior of the hood 13 and Transport container 20 encompassed interior may be a sterile room 19 , at least when the connection between the two subspaces of hood 13 and transport container 20 is opened, such as in FIG. 1a shown in the left half and in the hood 13 a sterilizer is present.
  • hood 13 is at its open bottom by means of a one-piece or multi-part, preferably hinged to the hood 13 hood cover 24 germ-tight closed and the transport container 20 by means of the mentioned container lid 23rd
  • the two covers 23, 24 are positioned so in the open state that you do not hinder the processing of the standing in the transport container 20 bottles 1, so for example, their filling or closing.
  • FIG. 1 a is arranged inside the hood 13, a filling head 14 , each with a filler neck over each of the bottles 1, which are in the filling position, and which can be lowered down to the bottles 1 .
  • hood 13 Inside the hood 13 further two sterilizing devices 25 are arranged, which are able to sterilize the interior of the hood 13 and optionally the connected transport container 20 and thus to make a sterile space 19 .
  • the container lid 23 of the transport container 20 is closed - possibly after closing the bottles 1 by screwing the caps 22 also in this state - before the hood 13 is lifted so that the transport container 20 thereafter maintaining the sterility in its interior in the capping 6 or a further necessary work station continues, as shown in Fig. 1e.
  • the hood cover 24 of the hood 13 can be closed, if it is present at all, and in this state another sterilization of the interior of the hood 13 are performed.
  • hood 13 has no own hood lid, so after sterilization from the transport container 20 is not sterilized separately, but after the germ-tight placement of the hood 13 is sterilized by means of the sterilization devices 25 , either before opening the container lid 23 or thereafter, or both.
  • FIG. 1a In contrast to FIG. 1a consists of the container lid 23 in FIG. 1b not from two articulated parts, but from two individual, liftable from the transport container 20 container lids 23, the For example, by means of a arranged in the hood 13 mechanism and lifted, and can be spent in an open position within the hood 13 .
  • the driving force for opening the container lid 23 and / or the hood cover 24 is preferably realized from outside the hood 13 and / or the transport container 20 without mechanical passage through the walls, for example by means of electromechanical forces or magnetic forces.
  • a transport device 8 which has a running in the transport direction 10 sheet body 18 , on its upper and lower guide rails 18a are present for the carriage 9 running there, each of which can carry a transport container 20 in a defined position.
  • the carriage 9 are individually and independently along the transport device movable with separate speed, independent holding times, also forward and backward movable, controlled by the control of the entire system.
  • conveyor belt 30 is supplied to the gripping area of a so-called picker 29, so one of a movable in the horizontal plane and the height of the robot arm with a gripper, which - together with an optical detection of the bottles - on the conveyor belt 30 in the situation is to remove the bottles 1 from the conveyor belt and in the space provided in the designated grid grid 27, which is suitable for the particular application in the transport container 20 , put into it.
  • the deposition of the container caps 22 on this grid at the intended positions is possible in this way, which are supplied simultaneously with the bottles or separately elsewhere.
  • the equipped with bottles 1 transport container 20 then continue along the upper guide track 18a in the sterilization station 4th
  • the inserted, still empty bottles 1 are sterilized, preferably by a hood 13, in the inside of the sterilizing device 25 is arranged and which is like the picker 29 attached to the overlying trusses of the machine frame, this time by means of a lifting linkage 31 the transport container 20 are lowered germ-tight and then set by means of go in the sterilizer 25 sterilized.
  • the container lid 23 is closed, so that the interior of the transport container 20 remains sterile, and after lifting the hood 13 in the interior sterile transport container 20 process in the filling station 5 .
  • a germinable on the transport container 20 hood 13 is placed on this, in contrast to the sterilization station 4 inside a filling head 14 with snorkelling for lowering into the bottles 1 and filling the bottles has.
  • the container lid 23 is opened after the germ-proof placement of this hood 13 , z. B. folded up to the side within the hood 13 and an optionally on the hood 13 existing hood cover 24 also, so after placing the hood and before opening the container lid 23, opened.
  • one or more additional sterilization devices may be present in the hood 13 in addition to the filling head 14 .
  • the transport container 20 can be moved further into the discharge station 7 , without having to close the container lid 23 again germ-tight.
  • a gripping tool without germ-tight surrounding hood is lowered onto the bottles 1, takes them and puts them in groups, eg. B. in an outer packaging 28, from, which is located in the working area of this gripping device and may for example stand on a conveyor belt 30 .
  • this section of the web body 18 pivots about its longitudinal axis by 180 ° , so that the carriage 9 with the corresponding empty transport container 20 hanging down on the lower guide track 18b of the sheet body 18 is located.
  • this transport container 20 is moved along the lower guide track 18b suspended to the beginning of the transport device and cleaned on the way to a cleaning station 12 in the downwardly open state by means of liquid or gas remaining in the transport container 20 liquid or solid deposits.
  • the germ-tight sealable container lid 23 in the individual workstations or multiple workstations across sterile rooms 19 may be provided in the Carriage 9 with the transport containers 20 located thereon and the first packages contained therein, ie bottles 1, alternately in and out.
  • a sterile lock must be present at the entrance and exit of the sterile room 19 into which the transport container 20 with the carriage 9 travels and after closing the sterile lock 32, the interior of the sterile lock 32 together with the transport container 20 therein , for this purpose course, must be open, sterilized.
  • a sterile bulkhead 17 is provided - as in FIG. 4 shown - which is tightly closed by extending it as a sliding gate or flap in the closed state through a gap in the web body 18 of the transport device 8 , but the gap on the other hand is so short dimensioned that the carriage 9 can drive over it.
  • the so equipped transport container 20 is further moved in the direction of transport 10 in the direction of sterilizing station 4, of which in this case two consecutively in the transport direction 10 are present, since the sterilization often requires a long cycle time.
  • a buffer line 34 for buffering transport containers 20 with bottles 1 is provided between the grouping station 3 and the sterilization station 4 .
  • the transport containers 20 with bottles 1 inserted therein can either be sterilized by means of a dense placing of a hood 13 on the transport containers 20 - as explained with reference to the remaining figures, in which case only the space within the hood 13 and the transport container 20 is sterilized, or without placing such a hood 13, by the entire transport container 20 including the carriage carrying him 9 and the underlying sheet body 18th the transport device 8 are located in this area within a sterile room 19 . Then, however, a sterile lock 32 is necessary for the inlet and outlet as a rule, in FIG. 2 is not shown separately, but based on the FIG. 4 is explained in a possible design.
  • the transport container 20 has a lid 23 which can be closed in a germ-tight manner , which is closed before sterilization ends in the sterilization stations 4 , so that the transport containers 20 subsequently transported on the transport device 8 and optionally cached at a further buffer section 34 under the closed lid 23 still empty and open Bottles are kept germ-proof.

Landscapes

  • Engineering & Computer Science (AREA)
  • Mechanical Engineering (AREA)
  • Filling Of Jars Or Cans And Processes For Cleaning And Sealing Jars (AREA)
  • Basic Packing Technique (AREA)

Claims (12)

  1. Machine d'emballage pour un produit à emballer de manière stérile dans des emballages primaires (1), comprenant :
    - un poste d'alimentation (2) pour fournir les emballages primaires (1),
    - un poste de groupage (3) pour grouper les emballages primaires (1),
    - un poste de remplissage (5) pour remplir les emballages primaires (1),
    - un poste de fermeture (6) pour fermer les emballages primaires remplis (1),
    - un poste d'enlèvement (7) pour évacuer les emballages primaires fermés (1),
    - un dispositif de transport (8) pour raccorder les postes (2 à 7) par plusieurs chariots (9) déplaçables, indépendamment l'un de l'autre, en particulier le long de la voie de guidage d'un corps de voies (18), lesquels chariots portent l'emballage primaire (1),
    - un poste de stérilisation (4) pour stériliser les récipients de transport (20) ainsi que les emballages primaires vides (1) qui y sont chargés,
    caractérisée en ce que la machine comprend des récipients de transport (20) déplaçables au moyen respectivement d'un chariot (9) avec une fermeture stérile, qui peut être ouverte et également refermée, pour recevoir les emballages primaires (1).
  2. Machine d'emballage selon la revendication 1,
    caractérisée en ce que :
    la machine d'emballage comprend un poste de nettoyage (12) pour éliminer les dépôts solides ou liquides dans les récipients de transport (20).
  3. Machine d'emballage selon l'une quelconque des revendications précédentes,
    caractérisée en ce que :
    le corps de voies (18) comprend des sections qui peuvent être déplacées, en particulier soumises à une rotation autour de la direction d'écoulement (10) et le corps de voies (18) présente une voie de guidage (18a, b) autant sur la face supérieure que sur la face inférieure.
  4. Machine d'emballage selon l'une quelconque des revendications précédentes,
    caractérisée en ce que :
    le poste de nettoyage (12) se trouve en dessous du corps de voies (18) et les récipients de transport (20) suspendus sur les chariots (9) de la voie de guidage inférieure (18a, b).
  5. Machine d'emballage selon l'une quelconque des revendications précédentes,
    caractérisée en ce que :
    - le poste de stérilisation (4) comprend un dispositif de stérilisation (25) qui peut être raccordé de manière étanche aux récipients de transport (20), est en particulier conçu comme un capot (13) et repose de manière étanche sur le récipient de transport en forme d'auge (20), et
    - la tête de remplissage (14) comprend un outil de fermeture (15) pour fermer les emballages primaires (1).
  6. Machine d'emballage selon l'une quelconque des revendications précédentes,
    caractérisée en ce que :
    - la machine d'emballage comprend plusieurs postes de stérilisation (4) disposés l'un derrière l'autre ou en parallèle l'un à côté de l'autre, et/ou
    - les récipients de transport (20) présentent, en particulier sur sa face supérieure, un dispositif de fermeture (16) à fermeture stérile, qui est conçu en particulier de manière à ne pas gêner l'installation d'un dispositif de stérilisation (25) à l'état ouvert.
  7. Machine d'emballage selon l'une quelconque des revendications précédentes,
    caractérisé en ce que :
    - le récipient de transport (20) comprend comme dispositif de fermeture un couvercle (16) repliable vers le haut, en particulier segmenté et/ou un couvercle complètement retirable (16) et/ou
    - les composants déplacés du récipient de transport (20), en particulier son couvercle (16), sont déclenchés sans contact, en particulier sous l'effet d'une force magnétique, de l'extérieur du récipient de transport (20), en particulier actionnés par le chariot (9) ou par l'outil intervenant sur les récipients de transport (20).
  8. Procédé de remplissage stérile d'un produit dans un emballage primaire, comprenant les étapes consistant à :
    - acheminer les emballages primaires (1),
    - insérer les emballages primaires (1) dans des récipients de transport (20),
    - stériliser les emballages primaires (1) dans le récipient de transport (20),
    - remplir les emballages primaires (1) avec le produit,
    - fermer les emballages primaires remplis (1), et
    - évacuer les emballages primaires (1) remplis et fermés,
    dans lequel :
    - les récipients de transport (20) sont déplacés, indépendamment l'un de l'autre, en particulier le long d'une ou plusieurs voies de guidage (18a, b),
    caractérisé en ce que :
    les emballages primaires (1) sont maintenus stériles de la stérilisation à la fermeture, les récipients de transport (20) pouvant être refermés de manière stérile et étant ouverts et refermés de manière limitée dans le temps dans un environnement stérile pour le remplissage et la fermeture des emballages primaires (1).
  9. Procédé selon la revendication 8,
    caractérisé en ce que :
    - les récipients de transport (20) sont stérilisés par raccordement étanche à un dispositif de stérilisation et/ou
    - le remplissage et la fermeture sont réalisés dans le même poste de travail, en particulier sans sortir de l'espace stérile (19).
  10. Procédé selon l'une quelconque des revendications précédentes, caractérisé en ce que :
    - la stérilisation se fait simultanément dans plusieurs postes de stérilisation (4) et, en particulier avant les postes de stérilisation (4), les récipients de transport arrivants (20) sont amortis et/ou entre les postes de stérilisation (4) et le poste de travail suivant, en particulier le poste de remplissage (5), les récipients de transport (20) sont amortis, et/ou
    - les chariots (9) avec les récipients de transport (20), au niveau de la transition de la zone stérile (19) à la zone non stérile (20) et vice-versa, débordent respectivement d'un intervalle (21) dans la voie de guidage (18a, b) et en particulier dans le corps de voies (18), par lequel intervalle une cloison stérile (17) peut être totalement fermée.
  11. Procédé selon l'une quelconque des revendications précédentes, caractérisé en ce que :
    - les récipients de transport stérilisés fermés (20) sont maintenus sous pression et/ou
    - la tête de remplissage (14) et/ou l'outil de fermeture (15) est ou sont stérilisés au cours du fonctionnement de la machine, en particulier si ces outils sont présents de manière redondante de sorte que l'un soit stabilisé tandis que l'autre travaille.
  12. Procédé selon l'une quelconque des revendications précédentes,
    caractérisé en ce que :
    - dans le cas de tubes de matière plastique comme emballages primaires (1), les tubes remplis sont fermés par scellage à ultrasons et, conjointement avec le scellage à ultrasons, des zones qui dépassent sont simultanément découpées et/ou
    - le scellage à ultrasons et/ou la découpe à ultrasons se fait ou se font avec le tube maintenu avec le joint de scellage tourné vers le haut et le déchet de tube séparé est évacué par air comprimé horizontalement vers le côté dans un récipient collecteur.
EP12194710.5A 2011-11-29 2012-11-29 Machine d'emballage pour conditionnement sans germe et method correspondante Not-in-force EP2599721B1 (fr)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE201110119657 DE102011119657B4 (de) 2011-11-29 2011-11-29 Verpackungsmaschine für keimfreies Abpacken

Publications (3)

Publication Number Publication Date
EP2599721A2 EP2599721A2 (fr) 2013-06-05
EP2599721A3 EP2599721A3 (fr) 2013-07-03
EP2599721B1 true EP2599721B1 (fr) 2015-09-30

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IT201800004068A1 (it) * 2018-03-29 2019-09-29 Marchesini Group Spa Macchina per il riempimento e la chiusura di contenitori farmaceutici, quali siringhe, flaconi e simili
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CN110371389B (zh) * 2019-07-29 2024-03-22 龙泉市恒丰汽车空调配件有限公司 一种储液干燥器柔性输送灌装生产线
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EP2599721A2 (fr) 2013-06-05
DE102011119657B4 (de) 2015-03-12
DE102011119657A1 (de) 2013-05-29

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