EP2539444A4 - Compositions et procédés pour la production de l-homoalanine - Google Patents

Compositions et procédés pour la production de l-homoalanine

Info

Publication number
EP2539444A4
EP2539444A4 EP11748179.6A EP11748179A EP2539444A4 EP 2539444 A4 EP2539444 A4 EP 2539444A4 EP 11748179 A EP11748179 A EP 11748179A EP 2539444 A4 EP2539444 A4 EP 2539444A4
Authority
EP
European Patent Office
Prior art keywords
homoalanine
compositions
production
methods
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Withdrawn
Application number
EP11748179.6A
Other languages
German (de)
English (en)
Other versions
EP2539444A2 (fr
Inventor
James C Liao
Kechun Zhang
Kwang Myung Cho
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
University of California
Original Assignee
University of California
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by University of California filed Critical University of California
Publication of EP2539444A2 publication Critical patent/EP2539444A2/fr
Publication of EP2539444A4 publication Critical patent/EP2539444A4/fr
Withdrawn legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/0004—Oxidoreductases (1.)
    • C12N9/0012—Oxidoreductases (1.) acting on nitrogen containing compounds as donors (1.4, 1.5, 1.6, 1.7)
    • C12N9/0014—Oxidoreductases (1.) acting on nitrogen containing compounds as donors (1.4, 1.5, 1.6, 1.7) acting on the CH-NH2 group of donors (1.4)
    • C12N9/0016—Oxidoreductases (1.) acting on nitrogen containing compounds as donors (1.4, 1.5, 1.6, 1.7) acting on the CH-NH2 group of donors (1.4) with NAD or NADP as acceptor (1.4.1)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P13/00—Preparation of nitrogen-containing organic compounds
    • C12P13/04—Alpha- or beta- amino acids
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P13/00—Preparation of nitrogen-containing organic compounds
    • C12P13/04—Alpha- or beta- amino acids
    • C12P13/06—Alanine; Leucine; Isoleucine; Serine; Homoserine
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Y—ENZYMES
    • C12Y104/00—Oxidoreductases acting on the CH-NH2 group of donors (1.4)
    • C12Y104/01—Oxidoreductases acting on the CH-NH2 group of donors (1.4) with NAD+ or NADP+ as acceptor (1.4.1)
    • C12Y104/01002—Glutamate dehydrogenase (1.4.1.2)
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/52—Improvements relating to the production of bulk chemicals using catalysts, e.g. selective catalysts

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Zoology (AREA)
  • Engineering & Computer Science (AREA)
  • Wood Science & Technology (AREA)
  • Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Microbiology (AREA)
  • Biotechnology (AREA)
  • Biochemistry (AREA)
  • General Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Biomedical Technology (AREA)
  • Molecular Biology (AREA)
  • Medicinal Chemistry (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
EP11748179.6A 2010-02-26 2011-02-25 Compositions et procédés pour la production de l-homoalanine Withdrawn EP2539444A4 (fr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US30874610P 2010-02-26 2010-02-26
PCT/US2011/026315 WO2011106696A2 (fr) 2010-02-26 2011-02-25 Compositions et procédés pour la production de l-homoalanine

Publications (2)

Publication Number Publication Date
EP2539444A2 EP2539444A2 (fr) 2013-01-02
EP2539444A4 true EP2539444A4 (fr) 2013-09-18

Family

ID=44507599

Family Applications (1)

Application Number Title Priority Date Filing Date
EP11748179.6A Withdrawn EP2539444A4 (fr) 2010-02-26 2011-02-25 Compositions et procédés pour la production de l-homoalanine

Country Status (4)

Country Link
US (2) US9187774B2 (fr)
EP (1) EP2539444A4 (fr)
CN (1) CN102884179A (fr)
WO (1) WO2011106696A2 (fr)

Families Citing this family (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
TWI557432B (zh) * 2011-06-13 2016-11-11 尼康股份有限公司 照明方法、曝光方法、元件製造方法、照明光學系統、以及曝光裝置
CN103215291B (zh) * 2012-01-18 2015-11-18 中国科学院上海生命科学研究院 用于生产l-2-氨基丁酸的载体、工程菌株及方法
US9777301B2 (en) 2012-12-13 2017-10-03 Industry-Academic Cooperation Foundation, Yonsei University Method for producing optically active amine compounds by deracemization
KR101493311B1 (ko) * 2012-12-13 2015-02-16 연세대학교 산학협력단 광학 활성 아민 및 호모알라닌의 제조방법
WO2016050959A2 (fr) * 2014-10-03 2016-04-07 Metabolic Explorer Glutamate déshydrogénase mutante pour la conversion d'homosérine en 4-hydroxy-2-cétobutyrate
CN106148259B (zh) * 2015-04-28 2019-09-10 中国科学院微生物研究所 生产l-2-氨基丁酸的重组菌及其制备方法与应用
CN105671098A (zh) * 2016-04-06 2016-06-15 河南巨龙生物工程股份有限公司 一种发酵法生产l-2-氨基丁酸的方法
CN108588045B (zh) * 2018-03-09 2019-12-10 浙江大学 谷氨酸脱氢酶突变体及其在制备l-草铵膦中的应用
CN110343676B (zh) * 2018-04-03 2020-06-23 上海弈柯莱生物医药科技有限公司 一种l-谷氨酸脱氢酶突变体及其应用
CN109266630B (zh) * 2018-08-31 2021-02-02 弈柯莱生物科技(上海)股份有限公司 一种脂肪酶及其在制备布瓦西坦中间体中的应用
WO2020070699A1 (fr) 2018-10-04 2020-04-09 Anna University Production de l-2-aminobutyrate à partir de citramalate, citraconate ou de 2-oxobutanoate
CN111321178B (zh) * 2020-03-02 2023-07-28 宁波酶赛生物工程有限公司 一种l-2-氨基丁酰胺的制备方法

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2005038017A2 (fr) * 2003-09-25 2005-04-28 Monsanto Technology Llc Procedes permettant d'empecher l'incorporation d'acides amines non standard dans des proteines

Family Cites Families (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4551433A (en) 1981-05-18 1985-11-05 Genentech, Inc. Microbial hybrid promoters
GB8412357D0 (en) 1984-05-15 1984-06-20 Ucb Sa Pharmaceutical composition
US4683202A (en) 1985-03-28 1987-07-28 Cetus Corporation Process for amplifying nucleic acid sequences
US6015891A (en) 1988-09-09 2000-01-18 Mycogen Plant Science, Inc. Synthetic insecticidal crystal protein gene having a modified frequency of codon usage
JPH03501682A (ja) * 1988-10-25 1991-04-18 味の素株式会社 Ｌ‐トレオニン生産者としてのエシェリキア・コリｂｋｉｉｍ　ｂ‐３９９６菌株
US5426039A (en) 1993-09-08 1995-06-20 Bio-Rad Laboratories, Inc. Direct molecular cloning of primer extended DNA containing an alkane diol
JP3510331B2 (ja) * 1994-06-30 2004-03-29 協和醗酵工業株式会社 発酵法によるｌ−アミノ酸の製造法
US6107492A (en) 1998-05-08 2000-08-22 Ucb, S.A. Process for the preparation of levetiracetam
US6451564B1 (en) * 1999-07-02 2002-09-17 Massachusetts Institute Of Technology Methods for producing L-isoleucine
US20060014259A9 (en) * 1999-07-09 2006-01-19 Kevin Burke Process for the preparation of L-amino acids with amplification of the zwf gene
EP1239041B1 (fr) * 2001-02-13 2006-04-19 Ajinomoto Co., Inc. Procédé de production des acides L-aminés au moyen de bactéries du genre Escherichia
US7531673B2 (en) 2004-02-18 2009-05-12 Dr. Reddy's Laboratories Limited Preparation of amino acid amides

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2005038017A2 (fr) * 2003-09-25 2005-04-28 Monsanto Technology Llc Procedes permettant d'empecher l'incorporation d'acides amines non standard dans des proteines

Non-Patent Citations (3)

* Cited by examiner, † Cited by third party
Title
See also references of WO2011106696A2 *
WANG X-G ET AL: "Conversion of a glutamate dehydrogenase into methionine/norleucine dehydrogenase by site-directed mutagenesis", EUROPEAN JOURNAL OF BIOCHEMISTRY, BLACKWELL PUBLISHING, BERLIN, DE, vol. 268, no. 22, 1 November 2001 (2001-11-01), pages 5791 - 5799, XP002262490, ISSN: 0014-2956, DOI: 10.1046/J.0014-2956.2001.02523.X *
WOLFGANG LEUCHTENBERGER ET AL: "Biotechnological production of amino acids and derivatives: current status and prospects", APPLIED MICROBIOLOGY AND BIOTECHNOLOGY, SPRINGER, BERLIN, DE, vol. 69, no. 1, 30 September 2005 (2005-09-30), pages 1 - 8, XP019331980, ISSN: 1432-0614, DOI: 10.1007/S00253-005-0155-Y *

Also Published As

Publication number Publication date
EP2539444A2 (fr) 2013-01-02
US20160053236A1 (en) 2016-02-25
WO2011106696A3 (fr) 2011-10-20
CN102884179A (zh) 2013-01-16
US9187774B2 (en) 2015-11-17
WO2011106696A2 (fr) 2011-09-01
US20130029386A1 (en) 2013-01-31
US9550980B2 (en) 2017-01-24

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