EP2496247A4 - Verfahren zur behandlung von fettleber - Google Patents
Verfahren zur behandlung von fettleberInfo
- Publication number
- EP2496247A4 EP2496247A4 EP10829042.0A EP10829042A EP2496247A4 EP 2496247 A4 EP2496247 A4 EP 2496247A4 EP 10829042 A EP10829042 A EP 10829042A EP 2496247 A4 EP2496247 A4 EP 2496247A4
- Authority
- EP
- European Patent Office
- Prior art keywords
- methods
- liver disease
- fatty liver
- treating fatty
- treating
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 208000010706 fatty liver disease Diseases 0.000 title 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/475—Growth factors; Growth regulators
- C07K14/495—Transforming growth factor [TGF]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/177—Receptors; Cell surface antigens; Cell surface determinants
- A61K38/1796—Receptors; Cell surface antigens; Cell surface determinants for hormones
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/68—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment
- A61K47/6835—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment the modifying agent being an antibody or an immunoglobulin bearing at least one antigen-binding site
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/04—Anorexiants; Antiobesity agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/06—Antihyperlipidemics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
- A61P5/48—Drugs for disorders of the endocrine system of the pancreatic hormones
- A61P5/50—Drugs for disorders of the endocrine system of the pancreatic hormones for increasing or potentiating the activity of insulin
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
- C07K14/71—Receptors; Cell surface antigens; Cell surface determinants for growth factors; for growth regulators
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C07K2319/30—Non-immunoglobulin-derived peptide or protein having an immunoglobulin constant or Fc region, or a fragment thereof, attached thereto
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Diabetes (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Gastroenterology & Hepatology (AREA)
- Immunology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Zoology (AREA)
- Endocrinology (AREA)
- Hematology (AREA)
- Obesity (AREA)
- Epidemiology (AREA)
- Cell Biology (AREA)
- Toxicology (AREA)
- Molecular Biology (AREA)
- Biochemistry (AREA)
- Biophysics (AREA)
- Genetics & Genomics (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Emergency Medicine (AREA)
- Child & Adolescent Psychology (AREA)
- Peptides Or Proteins (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Medicinal Preparation (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Priority Applications (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
EP20197939.0A EP3818988A1 (de) | 2009-11-03 | 2010-11-03 | Verfahren zur behandlung von fettleber |
EP17181410.6A EP3260130B1 (de) | 2009-11-03 | 2010-11-03 | Verfahren zur behandlung von fettleber |
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US28054409P | 2009-11-03 | 2009-11-03 | |
PCT/US2010/055331 WO2011056896A1 (en) | 2009-11-03 | 2010-11-03 | Methods for treating fatty liver disease |
Related Child Applications (3)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
EP17181410.6A Division EP3260130B1 (de) | 2009-11-03 | 2010-11-03 | Verfahren zur behandlung von fettleber |
EP17181410.6A Division-Into EP3260130B1 (de) | 2009-11-03 | 2010-11-03 | Verfahren zur behandlung von fettleber |
EP20197939.0A Division EP3818988A1 (de) | 2009-11-03 | 2010-11-03 | Verfahren zur behandlung von fettleber |
Publications (3)
Publication Number | Publication Date |
---|---|
EP2496247A1 EP2496247A1 (de) | 2012-09-12 |
EP2496247A4 true EP2496247A4 (de) | 2013-06-05 |
EP2496247B1 EP2496247B1 (de) | 2017-08-23 |
Family
ID=43970317
Family Applications (3)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
EP20197939.0A Pending EP3818988A1 (de) | 2009-11-03 | 2010-11-03 | Verfahren zur behandlung von fettleber |
EP17181410.6A Active EP3260130B1 (de) | 2009-11-03 | 2010-11-03 | Verfahren zur behandlung von fettleber |
EP10829042.0A Active EP2496247B1 (de) | 2009-11-03 | 2010-11-03 | Verfahren zur behandlung von fettleber |
Family Applications Before (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
EP20197939.0A Pending EP3818988A1 (de) | 2009-11-03 | 2010-11-03 | Verfahren zur behandlung von fettleber |
EP17181410.6A Active EP3260130B1 (de) | 2009-11-03 | 2010-11-03 | Verfahren zur behandlung von fettleber |
Country Status (7)
Country | Link |
---|---|
US (4) | US20110129469A1 (de) |
EP (3) | EP3818988A1 (de) |
JP (6) | JP5836961B2 (de) |
AU (4) | AU2010315245B2 (de) |
CA (1) | CA2779472C (de) |
ES (1) | ES2869864T3 (de) |
WO (1) | WO2011056896A1 (de) |
Families Citing this family (35)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JP2008507288A (ja) | 2004-07-23 | 2008-03-13 | アクセルロン ファーマ インコーポレーテッド | ActRII受容体ポリペプチド、方法、および組成物 |
KR20160137665A (ko) | 2005-11-23 | 2016-11-30 | 악셀레론 파마 인코포레이티드 | 액티빈-actrⅱa 길항제 및 골 성장을 촉진하기 위한 이들의 용도 |
US8128933B2 (en) | 2005-11-23 | 2012-03-06 | Acceleron Pharma, Inc. | Method of promoting bone growth by an anti-activin B antibody |
US8895016B2 (en) | 2006-12-18 | 2014-11-25 | Acceleron Pharma, Inc. | Antagonists of activin-actriia and uses for increasing red blood cell levels |
MX354099B (es) * | 2007-02-01 | 2018-02-13 | Acceleron Pharma Inc | Antagonistas de activina-actriia y usos para tratar o prevenir cancer de mama. |
TWI782836B (zh) | 2007-02-02 | 2022-11-01 | 美商艾瑟勒朗法瑪公司 | 衍生自ActRIIB的變體與其用途 |
DK2120999T3 (da) | 2007-02-09 | 2012-12-03 | Acceleron Pharma Inc | Farmaceutiske sammensætninger omfattende Activin-ActRIIA antagonister samt anvendelse deraf ved forebyggelse eller behandling af multipelt myelom |
EP3243524A1 (de) | 2007-09-18 | 2017-11-15 | Acceleron Pharma Inc. | Activin-actriia antagonisten und verfahren zur verringerung oder inhibierung der fsh-sekretion |
EP2315602A4 (de) * | 2008-06-26 | 2011-11-02 | Acceleron Pharma Inc | Verfahren zur dosierung eines actriib-antagonisten und überwachung von behandelten patienten |
US8216997B2 (en) | 2008-08-14 | 2012-07-10 | Acceleron Pharma, Inc. | Methods for increasing red blood cell levels and treating anemia using a combination of GDF traps and erythropoietin receptor activators |
TW201919685A (zh) | 2008-08-14 | 2019-06-01 | 美商艾瑟勒朗法瑪公司 | 使用gdf阱以增加紅血球水平 |
EP2387412A4 (de) | 2009-01-13 | 2013-04-03 | Acceleron Pharma Inc | Verfahren zur erhöhung des adiponectin-spiegels |
MX2011013172A (es) | 2009-06-08 | 2012-04-02 | Acceleron Pharma Inc | Metodos para aumentar adipocitos termogenicos. |
KR20120028358A (ko) | 2009-06-12 | 2012-03-22 | 악셀레론 파마 인코포레이티드 | 절두된 ActRIIB-FC 융합 단백질 |
EP3919068A1 (de) * | 2009-09-09 | 2021-12-08 | Acceleron Pharma Inc. | Actriib-antagonisten, ihre dosierung und anwendungen davon zur erhöhung der erythrozytenkonzentration |
JP6267425B2 (ja) | 2009-11-17 | 2018-01-24 | アクセルロン ファーマ, インコーポレイテッド | 筋ジストロフィー治療のためのユートロフィン誘導に関するactriibタンパク質およびその改変体およびその使用 |
JP2014502260A (ja) | 2010-11-08 | 2014-01-30 | アクセルロン ファーマ, インコーポレイテッド | Actriia結合剤およびその使用 |
KR20220156979A (ko) | 2012-11-02 | 2022-11-28 | 셀진 코포레이션 | 골 및 다른 장애를 치료하기 위한 액티빈-actrii 길항제 및 용도 |
DK2981822T3 (da) | 2013-05-06 | 2020-12-07 | Scholar Rock Inc | Sammensætninger og fremgangsmåder til vækstfaktormodulation |
CN107135646B (zh) | 2014-06-13 | 2022-03-15 | 阿塞勒隆制药公司 | 用于治疗溃疡的方法和组合物 |
MA41052A (fr) | 2014-10-09 | 2017-08-15 | Celgene Corp | Traitement d'une maladie cardiovasculaire à l'aide de pièges de ligands d'actrii |
US11471510B2 (en) | 2014-12-03 | 2022-10-18 | Celgene Corporation | Activin-ActRII antagonists and uses for treating anemia |
PL3280727T3 (pl) * | 2015-04-06 | 2021-07-19 | Acceleron Pharma Inc. | Jednoramienne białka fuzyjne receptora typu I i typu II i ich zastosowania |
CA2983440C (en) | 2015-04-22 | 2024-03-12 | Alivegen Usa Inc. | Novel hybrid actriib ligand trap proteins for treating muscle wasting diseases |
JP2018522579A (ja) | 2015-05-20 | 2018-08-16 | セルジーン コーポレイション | アクチビンII型受容体リガンドトラップを使用するβ−サラセミアのインビトロ細胞培養法 |
EP3439741A4 (de) * | 2016-04-06 | 2020-05-06 | Acceleron Pharma Inc. | Alk7-antagonisten und verwendungen davon |
JOP20190085A1 (ar) * | 2016-10-20 | 2019-04-17 | Biogen Ma Inc | طرق علاج الضمور العضلي ومرض العظام باستخدام بروتينات احتجاز مركب ترابطي actriib هجين حديثة |
CN110430890A (zh) | 2016-11-10 | 2019-11-08 | 科乐斯疗法公司 | 激活素受体iia型变体及其使用方法 |
KR20240014600A (ko) | 2017-03-24 | 2024-02-01 | 노바르티스 아게 | 심장질환 예방 및 치료 방법 |
KR20200085832A (ko) | 2017-11-09 | 2020-07-15 | 케로스 테라퓨틱스, 인크. | 액티빈 수용체 유형 iia 변이체 및 그의 사용 방법 |
CN112292144A (zh) | 2018-01-12 | 2021-01-29 | 科乐斯疗法公司 | 激活素受体iib型变体及其使用方法 |
BR112022003884A2 (pt) * | 2019-09-03 | 2022-05-31 | Novartis Ag | Tratamento de doença ou distúrbio hepático compreendendo antagonistas do receptor de actrii |
WO2022016084A1 (en) * | 2020-07-16 | 2022-01-20 | The Trustees Of Columbia University In The City Of New York | Targeting ltbp3 for nonalcoholic steatohepatitis (nash)-induced liver fibrosis |
WO2022016065A1 (en) * | 2020-07-16 | 2022-01-20 | The Trustees Of Columbia University In The City Of New York | Targeting adipsin for nonalcoholic steatohepatitis (nash)-induced liver fibrosis |
AU2021400488A1 (en) | 2020-12-14 | 2023-06-22 | Regeneron Pharmaceuticals, Inc. | Methods of treating metabolic disorders and cardiovascular disease with inhibin subunit beta e (inhbe) inhibitors |
Citations (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2008097541A2 (en) * | 2007-02-02 | 2008-08-14 | Acceleron Pharma Inc. | Variants derived from actriib and uses therefor |
Family Cites Families (96)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPH0637520B2 (ja) * | 1985-07-03 | 1994-05-18 | 味の素株式会社 | ポリペプチド |
AU597574B2 (en) | 1986-03-07 | 1990-06-07 | Massachusetts Institute Of Technology | Method for enhancing glycoprotein stability |
US4973577A (en) * | 1986-04-04 | 1990-11-27 | The Salk Institute For Biological Studies | FSH-releasing peptides |
US5080891A (en) | 1987-08-03 | 1992-01-14 | Ddi Pharmaceuticals, Inc. | Conjugates of superoxide dismutase coupled to high molecular weight polyalkylene glycols |
US5118667A (en) * | 1991-05-03 | 1992-06-02 | Celtrix Pharmaceuticals, Inc. | Bone growth factors and inhibitors of bone resorption for promoting bone formation |
US5885794A (en) * | 1991-05-10 | 1999-03-23 | The Salk Institute For Biological Studies | Recombinant production of vertebrate activin receptor polypeptides and identification of receptor DNAs in the activin/TGF-β superfamily |
US6162896A (en) * | 1991-05-10 | 2000-12-19 | The Salk Institute For Biological Studies | Recombinant vertebrate activin receptors |
US20050186593A1 (en) * | 1991-05-10 | 2005-08-25 | The Salk Institute For Biological Studies | Cloning and recombinant production of CRF receptor(s) |
US6287816B1 (en) * | 1991-06-25 | 2001-09-11 | Genetics Institute, Inc. | BMP-9 compositions |
US6692925B1 (en) * | 1992-11-17 | 2004-02-17 | Ludwig Institute For Cancer Research | Proteins having serine/threonine kinase domains, corresponding nucleic acid molecules, and their use |
US5808007A (en) * | 1993-01-12 | 1998-09-15 | The Johns Hopkins University School Of Medicine | Growth differentiation factor-3 |
US5637480A (en) * | 1993-05-12 | 1997-06-10 | Genetics Institute, Inc. | DNA molecules encoding bone morphogenetic protein-10 |
US5677196A (en) | 1993-05-18 | 1997-10-14 | University Of Utah Research Foundation | Apparatus and methods for multi-analyte homogeneous fluoro-immunoassays |
US5831050A (en) * | 1993-06-07 | 1998-11-03 | Creative Biomolecules, Inc. | Morphogen cell surface receptor |
US5525490A (en) | 1994-03-29 | 1996-06-11 | Onyx Pharmaceuticals, Inc. | Reverse two-hybrid method |
US5658876A (en) * | 1994-04-28 | 1997-08-19 | The General Hospital Corporation | Activin antagonists as novel contraceptives |
US5760010A (en) * | 1995-01-01 | 1998-06-02 | Klein; Ira | Method of treating liver disorders with a macrolide antibiotic |
US5814565A (en) | 1995-02-23 | 1998-09-29 | University Of Utah Research Foundation | Integrated optic waveguide immunosensor |
ATE352638T1 (de) | 1995-04-11 | 2007-02-15 | Gen Hospital Corp | REVERSE ßTWO-HYBRIDß-SYSTEME |
EP0771873A3 (de) * | 1995-10-27 | 1998-03-04 | Takeda Chemical Industries, Ltd. | Neuronales zellspezifisches Rezeptor-Protein |
US6004780A (en) * | 1996-03-26 | 1999-12-21 | Human Genome Sciences, Inc. | Growth factor HTTER36 |
US20050244867A1 (en) * | 1996-03-26 | 2005-11-03 | Human Genome Sciences, Inc. | Growth factor HTTER36 |
US6605699B1 (en) * | 1997-01-21 | 2003-08-12 | Human Genome Sciences, Inc. | Galectin-11 polypeptides |
US6231880B1 (en) * | 1997-05-30 | 2001-05-15 | Susan P. Perrine | Compositions and administration of compositions for the treatment of blood disorders |
US6891082B2 (en) * | 1997-08-01 | 2005-05-10 | The Johns Hopkins University School Of Medicine | Transgenic non-human animals expressing a truncated activintype II receptor |
US6696260B1 (en) * | 1997-08-01 | 2004-02-24 | The Johns Hopkins University School Of Medicine | Methods to identify growth differentiation factor (GDF) binding proteins |
US6656475B1 (en) * | 1997-08-01 | 2003-12-02 | The Johns Hopkins University School Of Medicine | Growth differentiation factor receptors, agonists and antagonists thereof, and methods of using same |
US6953662B2 (en) * | 1997-08-29 | 2005-10-11 | Human Genome Sciences, Inc. | Follistatin-3 |
EP1015468A4 (de) * | 1997-08-29 | 2000-09-06 | Human Genome Sciences Inc | Follistatin-3 |
US6696411B1 (en) * | 1998-04-22 | 2004-02-24 | Cornell Research Foundation, Inc. | Canine erythropoietin gene and recombinant protein |
BR9913857A (pt) * | 1998-09-17 | 2001-06-12 | Lilly Co Eli | Formulações de proteìna |
DE69934995T2 (de) * | 1998-09-22 | 2007-11-22 | Long Yu | Für den menschlichen wachstums-differenzierungsfaktor kodierende sequenz und polypeptid, welches durch solche dna-sequenz kodiert wird und verfahren zur herstellung |
US6548634B1 (en) * | 1998-09-30 | 2003-04-15 | Chiron Corporation | Synthetic peptides having FGF receptor affinity |
US6777205B1 (en) * | 1998-11-06 | 2004-08-17 | Sterrenbeld Biotechnologie North America, Inc. | Host cells expressing recombinant human erythropoietin |
DE60027135T2 (de) | 1999-01-21 | 2007-01-11 | Metamorphix, Inc. | Inhibitoren für wachstumdifferenzierungsfaktor und ihre anwendungen |
US6468543B1 (en) * | 1999-05-03 | 2002-10-22 | Zymogenetics, Inc. | Methods for promoting growth of bone using ZVEGF4 |
JP4487376B2 (ja) * | 2000-03-31 | 2010-06-23 | 味の素株式会社 | 腎疾患治療剤 |
US7087224B2 (en) * | 2000-10-31 | 2006-08-08 | Amgen Inc. | Method of treating anemia by administering IL-1ra |
TW200526779A (en) * | 2001-02-08 | 2005-08-16 | Wyeth Corp | Modified and stabilized GDF propeptides and uses thereof |
US20040132675A1 (en) * | 2002-02-08 | 2004-07-08 | Calvin Kuo | Method for treating cancer and increasing hematocrit levels |
JP2005508141A (ja) * | 2001-05-25 | 2005-03-31 | セローノ ジェネティクス インスティテュート ソシエテ アニニム | ヒトcDNAおよびタンパク質、ならびにそれらの使用 |
AUPR638101A0 (en) * | 2001-07-13 | 2001-08-09 | Bioa Pty Limited | Composition and method for treatment of disease |
US6855344B2 (en) * | 2001-07-17 | 2005-02-15 | Integrated Chinese Medicine Holdings, Ltd. | Compositions and methods for prostate and kidney health and disorders, an herbal preparation |
US7320789B2 (en) * | 2001-09-26 | 2008-01-22 | Wyeth | Antibody inhibitors of GDF-8 and uses thereof |
US6784154B2 (en) * | 2001-11-01 | 2004-08-31 | University Of Utah Research Foundation | Method of use of erythropoietin to treat ischemic acute renal failure |
US20030144203A1 (en) * | 2001-12-19 | 2003-07-31 | Voyager Pharmaceutical Corporation | Methods for slowing senescence and treating and preventing diseases associated with senescence |
US6998118B2 (en) * | 2001-12-21 | 2006-02-14 | The Salk Institute For Biological Studies | Targeted retrograde gene delivery for neuronal protection |
BR0307907A2 (pt) * | 2002-02-21 | 2011-07-05 | Wyeth Corp | gasp1: proteìna contendo domìnio de folistatina |
AR047392A1 (es) * | 2002-10-22 | 2006-01-18 | Wyeth Corp | Neutralizacion de anticuerpos contra gdf 8 y su uso para tales fines |
US20040223966A1 (en) * | 2002-10-25 | 2004-11-11 | Wolfman Neil M. | ActRIIB fusion polypeptides and uses therefor |
AU2002953327A0 (en) * | 2002-12-12 | 2003-01-09 | Monash University | Methods of diagnosing prognosing and treating activin associated diseases and conditions |
WO2004086953A2 (en) * | 2003-03-26 | 2004-10-14 | The Board Of Trustees Of The University Of Arkansas | Method for diagnosis and treatment of bone turnover |
WO2005028517A2 (en) * | 2003-05-09 | 2005-03-31 | The General Hospital Corporation | SOLUBLE TGF-β TYPE III RECEPTOR FUSION PROTEINS |
WO2005025601A1 (en) | 2003-09-15 | 2005-03-24 | Monash University | Follistatin isoforms and uses thereof |
US20050197292A1 (en) * | 2004-01-30 | 2005-09-08 | Glennda Smithson | Compositions and methods for treating T-cell mediated pathological conditions |
JP4688483B2 (ja) | 2004-04-15 | 2011-05-25 | 株式会社テクノネットワーク四国 | フォリスタチン変異体ポリペプチド |
US20100183695A1 (en) | 2004-05-27 | 2010-07-22 | John Knopf | Cerberus/coco derivatives and uses thereof |
AU2005258286A1 (en) | 2004-06-24 | 2006-01-05 | Acceleron Pharma Inc. | GDF3 propeptides and related methods |
JP2008507288A (ja) * | 2004-07-23 | 2008-03-13 | アクセルロン ファーマ インコーポレーテッド | ActRII受容体ポリペプチド、方法、および組成物 |
US8222029B2 (en) * | 2005-05-16 | 2012-07-17 | Institut Pasteur | Lentiviral vector-based vaccine |
JP2007099764A (ja) * | 2005-09-09 | 2007-04-19 | Ajinomoto Co Inc | 血糖低下剤 |
US8067562B2 (en) | 2005-11-01 | 2011-11-29 | Amgen Inc. | Isolated nucleic acid molecule comprising the amino acid sequence of SEQ ID NO:1 |
KR20160137665A (ko) * | 2005-11-23 | 2016-11-30 | 악셀레론 파마 인코포레이티드 | 액티빈-actrⅱa 길항제 및 골 성장을 촉진하기 위한 이들의 용도 |
EP1966183A4 (de) * | 2005-12-20 | 2010-12-29 | Merck Frosst Canada Ltd | Heteroaromatische verbindungen als inhibitoren von stearoyl-coenzym a-delta-9-desaturase |
JP2009521452A (ja) * | 2005-12-21 | 2009-06-04 | シェーリング コーポレイション | コレステロール降下剤およびh3受容体アンタゴニスト/逆アゴニストを使用する非アルコール性脂肪性肝疾患の処置 |
WO2007076127A2 (en) * | 2005-12-22 | 2007-07-05 | Biogen Idec Ma Inc | Condensed imidazoles or pyrazoles and their use as transforming growth factor modulators |
US7361512B2 (en) * | 2006-01-20 | 2008-04-22 | Beckman Coulter, Inc. | Low hemoglobin concentration cell percentage and method of use in detection of iron deficiency |
US7820721B2 (en) * | 2006-01-25 | 2010-10-26 | Wellstat Therapeutics Corporation | Compounds for the treatment of metabolic disorders |
CN101394738A (zh) * | 2006-02-28 | 2009-03-25 | 维尔斯达医疗公司 | 用于治疗代谢紊乱的化合物 |
US7972599B2 (en) | 2006-03-20 | 2011-07-05 | University Of Pittsburgh Of The Commonwealth System Of Higher Education | Immunomodulation of inflammatory conditions utilizing Follistatin-like protein-1 and agents that bind thereto |
WO2007120767A2 (en) * | 2006-04-14 | 2007-10-25 | Amgen Inc. | Agonist erythropoietin receptor antibodies |
EP2023913A2 (de) * | 2006-05-09 | 2009-02-18 | Colorado State University Research Foundation | Verfahren zur behandlung von blutkrankheiten |
ES2382993T3 (es) * | 2006-07-21 | 2012-06-15 | Lyne Laboratories, Inc. | Composición líquida de acetato de calcio |
US7547781B2 (en) * | 2006-09-11 | 2009-06-16 | Curis, Inc. | Quinazoline based EGFR inhibitors containing a zinc binding moiety |
ES2569365T3 (es) | 2006-11-29 | 2016-05-10 | Nationwide Children's Hospital | Inhibición de miostatina para la potenciación de músculo y/o la mejora de la función muscular |
NZ707292A (en) * | 2006-12-18 | 2017-06-30 | Acceleron Pharma Inc | Activin-actrii antagonists and uses for increasing red blood cell levels |
US8895016B2 (en) * | 2006-12-18 | 2014-11-25 | Acceleron Pharma, Inc. | Antagonists of activin-actriia and uses for increasing red blood cell levels |
US20100028332A1 (en) * | 2006-12-18 | 2010-02-04 | Acceleron Pharma Inc. | Antagonists of actriib and uses for increasing red blood cell levels |
MX354099B (es) * | 2007-02-01 | 2018-02-13 | Acceleron Pharma Inc | Antagonistas de activina-actriia y usos para tratar o prevenir cancer de mama. |
DK2120999T3 (da) * | 2007-02-09 | 2012-12-03 | Acceleron Pharma Inc | Farmaceutiske sammensætninger omfattende Activin-ActRIIA antagonister samt anvendelse deraf ved forebyggelse eller behandling af multipelt myelom |
TW201718635A (zh) | 2007-03-06 | 2017-06-01 | 安美基公司 | 變異之活動素受體多肽及其用途 |
US8236751B2 (en) | 2007-03-07 | 2012-08-07 | The Johns Hopkins University | Methods of increasing muscle mass using follistatin-like related gene (FLRG) |
EP2150560A1 (de) * | 2007-06-01 | 2010-02-10 | Wyeth | Verfahren und zusammensetzungen zur modulierung der bmp10-aktivität |
WO2009009059A1 (en) * | 2007-07-09 | 2009-01-15 | Biogen Idec Ma Inc. | Spiro compounds as antagonists of tgf-beta |
EP3243524A1 (de) * | 2007-09-18 | 2017-11-15 | Acceleron Pharma Inc. | Activin-actriia antagonisten und verfahren zur verringerung oder inhibierung der fsh-sekretion |
PE20091163A1 (es) * | 2007-11-01 | 2009-08-09 | Wyeth Corp | Anticuerpos para gdf8 |
EP2315602A4 (de) * | 2008-06-26 | 2011-11-02 | Acceleron Pharma Inc | Verfahren zur dosierung eines actriib-antagonisten und überwachung von behandelten patienten |
TW201919685A (zh) * | 2008-08-14 | 2019-06-01 | 美商艾瑟勒朗法瑪公司 | 使用gdf阱以增加紅血球水平 |
US8216997B2 (en) * | 2008-08-14 | 2012-07-10 | Acceleron Pharma, Inc. | Methods for increasing red blood cell levels and treating anemia using a combination of GDF traps and erythropoietin receptor activators |
EP2387412A4 (de) * | 2009-01-13 | 2013-04-03 | Acceleron Pharma Inc | Verfahren zur erhöhung des adiponectin-spiegels |
NO2424895T3 (de) * | 2009-04-27 | 2018-02-03 | ||
MX2011013172A (es) * | 2009-06-08 | 2012-04-02 | Acceleron Pharma Inc | Metodos para aumentar adipocitos termogenicos. |
KR20120028358A (ko) * | 2009-06-12 | 2012-03-22 | 악셀레론 파마 인코포레이티드 | 절두된 ActRIIB-FC 융합 단백질 |
EP3919068A1 (de) * | 2009-09-09 | 2021-12-08 | Acceleron Pharma Inc. | Actriib-antagonisten, ihre dosierung und anwendungen davon zur erhöhung der erythrozytenkonzentration |
JP6267425B2 (ja) * | 2009-11-17 | 2018-01-24 | アクセルロン ファーマ, インコーポレイテッド | 筋ジストロフィー治療のためのユートロフィン誘導に関するactriibタンパク質およびその改変体およびその使用 |
AU2016359695A1 (en) * | 2015-11-23 | 2018-06-14 | Acceleron Pharma Inc. | Methods for treating eye disorders |
-
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Patent Citations (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2008097541A2 (en) * | 2007-02-02 | 2008-08-14 | Acceleron Pharma Inc. | Variants derived from actriib and uses therefor |
Non-Patent Citations (3)
Title |
---|
A. KONCAREVIC ET AL: "A Soluble Activin Receptor Type IIB Prevents the Effects of Androgen Deprivation on Body Composition and Bone Health", ENDOCRINOLOGY, vol. 151, no. 9, 1 September 2010 (2010-09-01), pages 4289 - 4300, XP055060206, ISSN: 0013-7227, DOI: 10.1210/en.2010-0134 * |
AKPAN I ET AL: "The effects of a soluble activin type IIB receptor on obesity and insulin sensitivity", INTERNATIONAL JOURNAL OF OBESITY, NEWMAN PUBLISHING, LONDON, GB, vol. 33, no. 11, 1 November 2009 (2009-11-01), pages 1265 - 1273, XP002692695, ISSN: 0307-0565 * |
NORBERTO-C CHAVEZ-TAPIA ET AL: "Insulin sensitizers in treatment of nonalcoholic fatty liver disease: Systematic review.", WORLD JOURNAL OF GASTROENTEROLOGY, vol. 12, no. 48, 1 December 2006 (2006-12-01), pages 7826 - 7831, XP055060338, ISSN: 1007-9327 * |
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AU2021290230A1 (en) | 2022-01-20 |
JP2018123170A (ja) | 2018-08-09 |
CA2779472C (en) | 2021-03-16 |
WO2011056896A1 (en) | 2011-05-12 |
US20160318983A1 (en) | 2016-11-03 |
AU2019206030B2 (en) | 2021-09-30 |
CA2779472A1 (en) | 2011-05-12 |
AU2017200612B2 (en) | 2019-04-18 |
EP3260130A2 (de) | 2017-12-27 |
AU2017200612A1 (en) | 2017-02-23 |
US20190062392A1 (en) | 2019-02-28 |
EP3260130A3 (de) | 2018-02-07 |
ES2869864T3 (es) | 2021-10-26 |
JP5836961B2 (ja) | 2015-12-24 |
EP2496247A1 (de) | 2012-09-12 |
AU2019206030A1 (en) | 2019-08-08 |
AU2010315245B2 (en) | 2016-11-03 |
EP2496247B1 (de) | 2017-08-23 |
JP2017057228A (ja) | 2017-03-23 |
JP2015143274A (ja) | 2015-08-06 |
US20210269494A1 (en) | 2021-09-02 |
AU2010315245A1 (en) | 2012-05-24 |
EP3818988A1 (de) | 2021-05-12 |
EP3260130B1 (de) | 2021-03-10 |
JP2022060583A (ja) | 2022-04-14 |
US20110129469A1 (en) | 2011-06-02 |
JP2013510090A (ja) | 2013-03-21 |
JP2020114884A (ja) | 2020-07-30 |
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