EP2473198A4 - SYSTEMS AND METHODS FOR PRODUCING HYPERPOLARIZED MATERIALS AND MIXTURES THEREOF - Google Patents

SYSTEMS AND METHODS FOR PRODUCING HYPERPOLARIZED MATERIALS AND MIXTURES THEREOF

Info

Publication number
EP2473198A4
EP2473198A4 EP10812752.3A EP10812752A EP2473198A4 EP 2473198 A4 EP2473198 A4 EP 2473198A4 EP 10812752 A EP10812752 A EP 10812752A EP 2473198 A4 EP2473198 A4 EP 2473198A4
Authority
EP
European Patent Office
Prior art keywords
mixtures
systems
methods
producing hyperpolarized
hyperpolarized materials
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Withdrawn
Application number
EP10812752.3A
Other languages
German (de)
English (en)
French (fr)
Other versions
EP2473198A2 (en
Inventor
Neal Kalechofsky
Avrum Belzer
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
MILLIKELVIN TECHNOLOGIES LLC
Original Assignee
MILLIKELVIN TECHNOLOGIES LLC
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by MILLIKELVIN TECHNOLOGIES LLC filed Critical MILLIKELVIN TECHNOLOGIES LLC
Publication of EP2473198A2 publication Critical patent/EP2473198A2/en
Publication of EP2473198A4 publication Critical patent/EP2473198A4/en
Withdrawn legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/06—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/06—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations
    • A61K49/08—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations characterised by the carrier
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01R—MEASURING ELECTRIC VARIABLES; MEASURING MAGNETIC VARIABLES
    • G01R33/00—Arrangements or instruments for measuring magnetic variables
    • G01R33/20—Arrangements or instruments for measuring magnetic variables involving magnetic resonance
    • G01R33/28—Details of apparatus provided for in groups G01R33/44 - G01R33/64
    • G01R33/282—Means specially adapted for hyperpolarisation or for hyperpolarised contrast agents, e.g. for the generation of hyperpolarised gases using optical pumping cells, for storing hyperpolarised contrast agents or for the determination of the polarisation of a hyperpolarised contrast agent

Landscapes

  • Health & Medical Sciences (AREA)
  • Physics & Mathematics (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Radiology & Medical Imaging (AREA)
  • Epidemiology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Physics & Mathematics (AREA)
  • Condensed Matter Physics & Semiconductors (AREA)
  • Magnetic Resonance Imaging Apparatus (AREA)
  • Physical Or Chemical Processes And Apparatus (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Saccharide Compounds (AREA)
  • Apparatus Associated With Microorganisms And Enzymes (AREA)
EP10812752.3A 2009-08-31 2010-08-31 SYSTEMS AND METHODS FOR PRODUCING HYPERPOLARIZED MATERIALS AND MIXTURES THEREOF Withdrawn EP2473198A4 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US23864709P 2009-08-31 2009-08-31
PCT/US2010/047310 WO2011026103A2 (en) 2009-08-31 2010-08-31 Systems and methods for producing hyperpolarized materials and mixtures thereof

Publications (2)

Publication Number Publication Date
EP2473198A2 EP2473198A2 (en) 2012-07-11
EP2473198A4 true EP2473198A4 (en) 2015-06-24

Family

ID=43628703

Family Applications (1)

Application Number Title Priority Date Filing Date
EP10812752.3A Withdrawn EP2473198A4 (en) 2009-08-31 2010-08-31 SYSTEMS AND METHODS FOR PRODUCING HYPERPOLARIZED MATERIALS AND MIXTURES THEREOF

Country Status (9)

Country Link
EP (1) EP2473198A4 (enExample)
JP (1) JP5792726B2 (enExample)
KR (1) KR20120101339A (enExample)
CN (1) CN102753201A (enExample)
AU (1) AU2010286413B2 (enExample)
CA (1) CA2772190A1 (enExample)
IN (1) IN2012DN02418A (enExample)
SG (1) SG178927A1 (enExample)
WO (1) WO2011026103A2 (enExample)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU2007254464B2 (en) 2006-02-21 2013-02-21 Avrum Belzer Hyperpolarization methods, systems and compositions
US8703102B2 (en) 2008-04-04 2014-04-22 Millikelvin Technologies Llc Systems and methods for producing hyperpolarized materials and mixtures thereof
GB2498181A (en) 2011-12-29 2013-07-10 Bruker Biospin Gmbh Device and method for rapid dynamic nuclear polarisation
US9329246B2 (en) 2012-10-03 2016-05-03 Bruker Biospin Ag Method for hyperpolarization transfer in the liquid state
US9404984B2 (en) 2012-11-06 2016-08-02 Bruker Uk Limited Method of hyperpolarization applying brute force using particulate acceleration agents

Family Cites Families (23)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5545396A (en) * 1994-04-08 1996-08-13 The Research Foundation Of State University Of New York Magnetic resonance imaging using hyperpolarized noble gases
US5617859A (en) 1995-10-02 1997-04-08 General Electric Company Apparatus and methods for magnetic resonance (MR) imaging of cavities using fluids polarized at low temperatures
RU2186405C2 (ru) 1996-03-29 2002-07-27 Лоренс Беркли Нэшнл Лэборэтори Усиление ядерного магнитного резонанса (ямр) и магниторезонансной визуализации (мрв) в присутствии гиперполяризованных благородных газов
CN1224502A (zh) * 1996-03-29 1999-07-28 劳伦斯·伯克利国家实验室 利用超极化惰性气体对于核磁共振和磁共振成象质量的提高
US5809801A (en) * 1996-03-29 1998-09-22 The Trustees Of Princeton University Cryogenic accumulator for spin-polarized xenon-129
GB9614139D0 (en) 1996-07-05 1996-09-04 Nycomed Imaging As Method
DE69820415T2 (de) * 1997-01-08 2004-09-16 Amersham Health As Verfahren zur bilderzeugung mit magnetischer resonanz
AU8119298A (en) * 1997-06-19 1999-01-04 Nycomed Imaging As Overhauser magnetic resonance imaging (ormi) method comprising ex vivo polarization of a magnetic resonance (mr) imaging agent
WO1999024080A1 (en) 1997-11-12 1999-05-20 Nycomed Imaging As Para-hydrogen labelled agents and their use in magnetic resonance imaging
US6278893B1 (en) * 1998-01-05 2001-08-21 Nycomed Imaging As Method of magnetic resonance imaging of a sample with ex vivo polarization of an MR imaging agent
GB0001727D0 (en) 2000-01-25 2000-03-15 Oxford Instr Uk Ltd Hyperpolarization of a noble gas
AU1403902A (en) 2000-11-03 2002-05-15 Amersham Health As Methods and devices for polarised nmr samples
US7372274B2 (en) * 2000-11-03 2008-05-13 Ge Healthcare As Methods and devices configured for dissolving hyperpolarised solid material with a solvent within a cryostat for NMR analyses
NO20025738D0 (no) * 2002-11-29 2002-11-29 Amersham Health As Metode
DE102004002639A1 (de) * 2004-01-19 2005-09-15 Forschungszentrum Jülich GmbH Verfahren zur Anreicherung von hyperpolarisierten Atomkernen und Vorrichtung zur Durchführung des Verfahrens
GB0501346D0 (en) * 2005-01-21 2005-03-02 Oxford Instr Molecular Biotool Method of carrying out dynamic nuclear polarization
FR2881226B1 (fr) * 2005-01-27 2007-04-27 Commissariat Energie Atomique Accroissement de la polarisation des spins nucleaires d'une molecule via un transfert de polarisation de type hartmann-hahn utilisant le champ dipolaire moyen cree par une source
GB0514303D0 (en) * 2005-07-12 2005-08-17 Oxford Instr Molecular Biotool Magnet assembly
AU2007254464B2 (en) * 2006-02-21 2013-02-21 Avrum Belzer Hyperpolarization methods, systems and compositions
NL2000122C2 (nl) * 2006-07-03 2008-01-07 Vialle Alternative Fuel System Bufferhouder.
US7631507B2 (en) * 2006-11-02 2009-12-15 General Electric Company Methods and devices for polarized samples for use in MRI
US20080242974A1 (en) * 2007-04-02 2008-10-02 Urbahn John A Method and apparatus to hyperpolarize materials for enhanced mr techniques
US7519492B2 (en) * 2007-05-02 2009-04-14 General Electric Company Apparatus and method for fully automated closed system quality control of a substance

Non-Patent Citations (2)

* Cited by examiner, † Cited by third party
Title
See also references of WO2011026103A2 *
TOMASELLI M ET AL: "HAUPT MAGNETIC DOUBLE RESONANCE", JOURNAL OF CHEMICAL PHYSICS, AMERICAN INSTITUTE OF PHYSICS, US, vol. 118, no. 19, 15 May 2003 (2003-05-15), pages 8559 - 8562, XP009048801, ISSN: 0021-9606, DOI: 10.1063/1.1573635 *

Also Published As

Publication number Publication date
CA2772190A1 (en) 2011-03-03
WO2011026103A2 (en) 2011-03-03
CN102753201A (zh) 2012-10-24
KR20120101339A (ko) 2012-09-13
JP2013503021A (ja) 2013-01-31
JP5792726B2 (ja) 2015-10-14
EP2473198A2 (en) 2012-07-11
SG178927A1 (en) 2012-04-27
WO2011026103A3 (en) 2011-07-21
AU2010286413B2 (en) 2014-11-20
AU2010286413A1 (en) 2012-04-05
IN2012DN02418A (enExample) 2015-08-21

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Effective date: 20150522

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Ipc: A61K 49/00 20060101ALI20150518BHEP

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