WO2011026103A3 - Systems and methods for producing hyperpolarized materials and mixtures thereof - Google Patents

Systems and methods for producing hyperpolarized materials and mixtures thereof Download PDF

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Publication number
WO2011026103A3
WO2011026103A3 PCT/US2010/047310 US2010047310W WO2011026103A3 WO 2011026103 A3 WO2011026103 A3 WO 2011026103A3 US 2010047310 W US2010047310 W US 2010047310W WO 2011026103 A3 WO2011026103 A3 WO 2011026103A3
Authority
WO
WIPO (PCT)
Prior art keywords
systems
mixtures
methods
producing hyperpolarized
hyperpolarized materials
Prior art date
Application number
PCT/US2010/047310
Other languages
French (fr)
Other versions
WO2011026103A2 (en
Inventor
Neal Kalechofsky
Avrum Belzer
Original Assignee
Millikelvin Technologies Llc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority to AU2010286413A priority Critical patent/AU2010286413B2/en
Application filed by Millikelvin Technologies Llc filed Critical Millikelvin Technologies Llc
Priority to JP2012527097A priority patent/JP5792726B2/en
Priority to CN2010800471391A priority patent/CN102753201A/en
Priority to CA2772190A priority patent/CA2772190A1/en
Priority to SG2012014379A priority patent/SG178927A1/en
Priority to EP10812752.3A priority patent/EP2473198A4/en
Priority to IN2418DEN2012 priority patent/IN2012DN02418A/en
Priority to US12/879,634 priority patent/US8703102B2/en
Publication of WO2011026103A2 publication Critical patent/WO2011026103A2/en
Publication of WO2011026103A3 publication Critical patent/WO2011026103A3/en
Priority to US14/190,945 priority patent/US20140218029A1/en
Priority to US14/257,787 priority patent/US20140223923A1/en
Priority to US15/230,739 priority patent/US20170082711A1/en
Priority to US15/612,456 priority patent/US20170269180A1/en

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/06—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/06—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations
    • A61K49/08—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations characterised by the carrier
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01R—MEASURING ELECTRIC VARIABLES; MEASURING MAGNETIC VARIABLES
    • G01R33/00—Arrangements or instruments for measuring magnetic variables
    • G01R33/20—Arrangements or instruments for measuring magnetic variables involving magnetic resonance
    • G01R33/28—Details of apparatus provided for in groups G01R33/44 - G01R33/64
    • G01R33/282—Means specially adapted for hyperpolarisation or for hyperpolarised contrast agents, e.g. for the generation of hyperpolarised gases using optical pumping cells, for storing hyperpolarised contrast agents or for the determination of the polarisation of a hyperpolarised contrast agent

Abstract

The present disclosure provides various methods and systems for manufacture, transport and delivery of material including highly polarized nuclei that is in a hyperpolarized state.
PCT/US2010/047310 2006-02-21 2010-08-31 Systems and methods for producing hyperpolarized materials and mixtures thereof WO2011026103A2 (en)

Priority Applications (12)

Application Number Priority Date Filing Date Title
EP10812752.3A EP2473198A4 (en) 2009-08-31 2010-08-31 Systems and methods for producing hyperpolarized materials and mixtures thereof
JP2012527097A JP5792726B2 (en) 2009-08-31 2010-08-31 Method for producing a material containing hyperpolarized nuclei
CN2010800471391A CN102753201A (en) 2009-08-31 2010-08-31 Systems and methods for producing hyperpolarized materials and mixtures thereof
CA2772190A CA2772190A1 (en) 2009-08-31 2010-08-31 Systems and methods for producing hyperpolarized materials and mixtures thereof
SG2012014379A SG178927A1 (en) 2009-08-31 2010-08-31 Systems and methods for producing hyperpolarized materials and mixtures thereof
AU2010286413A AU2010286413B2 (en) 2009-08-31 2010-08-31 Systems and methods for producing hyperpolarized materials and mixtures thereof
IN2418DEN2012 IN2012DN02418A (en) 2009-08-31 2010-08-31
US12/879,634 US8703102B2 (en) 2008-04-04 2010-09-10 Systems and methods for producing hyperpolarized materials and mixtures thereof
US14/190,945 US20140218029A1 (en) 2006-02-21 2014-02-26 Techniques, systems and machine readable programs for magnetic resonance
US14/257,787 US20140223923A1 (en) 2008-04-04 2014-04-21 Systems and methods for producing hyperpolarized materials and mixtures thereof
US15/230,739 US20170082711A1 (en) 2006-02-21 2016-08-08 Techniques, systems and machine readable programs for magnetic resonance
US15/612,456 US20170269180A1 (en) 2006-02-21 2017-06-02 Systems and related methods for rapidly moving materials into and out of a cryogenic environment

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US23864709P 2009-08-31 2009-08-31
US61/238,647 2009-08-31

Related Parent Applications (4)

Application Number Title Priority Date Filing Date
PCT/US2009/039696 Continuation-In-Part WO2009146153A2 (en) 2006-02-21 2009-04-06 Manufacture, transport and delivery of material containing highly polarized nuclei
US12/879,634 Continuation-In-Part US8703102B2 (en) 2006-02-21 2010-09-10 Systems and methods for producing hyperpolarized materials and mixtures thereof
US14/190,945 Continuation US20140218029A1 (en) 2006-02-21 2014-02-26 Techniques, systems and machine readable programs for magnetic resonance
US15/230,739 Continuation-In-Part US20170082711A1 (en) 2006-02-21 2016-08-08 Techniques, systems and machine readable programs for magnetic resonance

Related Child Applications (1)

Application Number Title Priority Date Filing Date
US12/879,634 Continuation US8703102B2 (en) 2006-02-21 2010-09-10 Systems and methods for producing hyperpolarized materials and mixtures thereof

Publications (2)

Publication Number Publication Date
WO2011026103A2 WO2011026103A2 (en) 2011-03-03
WO2011026103A3 true WO2011026103A3 (en) 2011-07-21

Family

ID=43628703

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2010/047310 WO2011026103A2 (en) 2006-02-21 2010-08-31 Systems and methods for producing hyperpolarized materials and mixtures thereof

Country Status (9)

Country Link
EP (1) EP2473198A4 (en)
JP (1) JP5792726B2 (en)
KR (1) KR20120101339A (en)
CN (1) CN102753201A (en)
AU (1) AU2010286413B2 (en)
CA (1) CA2772190A1 (en)
IN (1) IN2012DN02418A (en)
SG (1) SG178927A1 (en)
WO (1) WO2011026103A2 (en)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1986702A4 (en) 2006-02-21 2012-12-12 Avrum Belzer Hyperpolarization methods, systems and compositions
US8703102B2 (en) 2008-04-04 2014-04-22 Millikelvin Technologies Llc Systems and methods for producing hyperpolarized materials and mixtures thereof
GB2498181A (en) * 2011-12-29 2013-07-10 Bruker Biospin Gmbh Device and method for rapid dynamic nuclear polarisation
US9329246B2 (en) 2012-10-03 2016-05-03 Bruker Biospin Ag Method for hyperpolarization transfer in the liquid state
US9404984B2 (en) 2012-11-06 2016-08-02 Bruker Uk Limited Method of hyperpolarization applying brute force using particulate acceleration agents

Citations (6)

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US5545396A (en) * 1994-04-08 1996-08-13 The Research Foundation Of State University Of New York Magnetic resonance imaging using hyperpolarized noble gases
US6453188B1 (en) * 1997-01-08 2002-09-17 Amersham Health As Method of magnetic resonance imaging
US6466814B1 (en) * 1998-01-05 2002-10-15 Amersham Health As Method of magnetic resonance investigation
US20040066193A1 (en) * 2000-11-03 2004-04-08 Ardenkjaer-Larsen Jan Henrik Methods and devices for dissolving hyperpolarised solid material for nmr analyses
US20070156046A1 (en) * 2004-01-19 2007-07-05 Hasing Friedrich W Method of enriching hyperpolarized atom nuclei and an apparatus for implementing the method
WO2007136439A2 (en) * 2006-02-21 2007-11-29 Avrum Belzer Hyperpolarization methods, systems and compositions

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US5617859A (en) 1995-10-02 1997-04-08 General Electric Company Apparatus and methods for magnetic resonance (MR) imaging of cavities using fluids polarized at low temperatures
CN1224502A (en) * 1996-03-29 1999-07-28 劳伦斯·伯克利国家实验室 Enhancement of NMR and MRI in presence of hyperpolarized noble gases
US5809801A (en) * 1996-03-29 1998-09-22 The Trustees Of Princeton University Cryogenic accumulator for spin-polarized xenon-129
US6426058B1 (en) 1996-03-29 2002-07-30 The Regents Of The University Of California Enhancement of NMR and MRI in the presence of hyperpolarized noble gases
GB9614139D0 (en) 1996-07-05 1996-09-04 Nycomed Imaging As Method
CN1269015A (en) * 1997-06-19 2000-10-04 耐克麦德英梅金公司 Overhauser magnetic resonance imaging (ORMI) method comprising ex vivo polarization of a magnetic resonance (MR) imaging agent
AU1047399A (en) 1997-11-12 1999-05-31 Nycomed Imaging As Para-hydrogen labelled agents and their use in magnetic resonance imaging
GB0001727D0 (en) 2000-01-25 2000-03-15 Oxford Instr Uk Ltd Hyperpolarization of a noble gas
IL155475A0 (en) 2000-11-03 2003-11-23 Amersham Health As Methods and devices for polarised nmr samples
NO20025738D0 (en) * 2002-11-29 2002-11-29 Amersham Health As Method
GB0501346D0 (en) * 2005-01-21 2005-03-02 Oxford Instr Molecular Biotool Method of carrying out dynamic nuclear polarization
FR2881226B1 (en) * 2005-01-27 2007-04-27 Commissariat Energie Atomique INCREASING THE POLARIZATION OF NUCLEAR SPINS OF A MOLECULE VIA HARTMANN-HAHN-TYPE POLARIZATION TRANSFER USING THE SOURCE-CREATED MEDIUM DIPOLAR FIELD
GB0514303D0 (en) * 2005-07-12 2005-08-17 Oxford Instr Molecular Biotool Magnet assembly
NL2000122C2 (en) * 2006-07-03 2008-01-07 Vialle Alternative Fuel System Buffer holder.
US7631507B2 (en) * 2006-11-02 2009-12-15 General Electric Company Methods and devices for polarized samples for use in MRI
US20080242974A1 (en) * 2007-04-02 2008-10-02 Urbahn John A Method and apparatus to hyperpolarize materials for enhanced mr techniques
US7519492B2 (en) * 2007-05-02 2009-04-14 General Electric Company Apparatus and method for fully automated closed system quality control of a substance

Patent Citations (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5545396A (en) * 1994-04-08 1996-08-13 The Research Foundation Of State University Of New York Magnetic resonance imaging using hyperpolarized noble gases
US6453188B1 (en) * 1997-01-08 2002-09-17 Amersham Health As Method of magnetic resonance imaging
US6466814B1 (en) * 1998-01-05 2002-10-15 Amersham Health As Method of magnetic resonance investigation
US20040066193A1 (en) * 2000-11-03 2004-04-08 Ardenkjaer-Larsen Jan Henrik Methods and devices for dissolving hyperpolarised solid material for nmr analyses
US20070156046A1 (en) * 2004-01-19 2007-07-05 Hasing Friedrich W Method of enriching hyperpolarized atom nuclei and an apparatus for implementing the method
WO2007136439A2 (en) * 2006-02-21 2007-11-29 Avrum Belzer Hyperpolarization methods, systems and compositions

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
See also references of EP2473198A4 *

Also Published As

Publication number Publication date
CN102753201A (en) 2012-10-24
CA2772190A1 (en) 2011-03-03
JP5792726B2 (en) 2015-10-14
EP2473198A4 (en) 2015-06-24
SG178927A1 (en) 2012-04-27
AU2010286413A1 (en) 2012-04-05
EP2473198A2 (en) 2012-07-11
JP2013503021A (en) 2013-01-31
KR20120101339A (en) 2012-09-13
IN2012DN02418A (en) 2015-08-21
AU2010286413B2 (en) 2014-11-20
WO2011026103A2 (en) 2011-03-03

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