EP2473198A4 - Systèmes et procédés permettant la production de matériaux hyperpolarisés et leurs mélanges - Google Patents

Systèmes et procédés permettant la production de matériaux hyperpolarisés et leurs mélanges

Info

Publication number
EP2473198A4
EP2473198A4 EP10812752.3A EP10812752A EP2473198A4 EP 2473198 A4 EP2473198 A4 EP 2473198A4 EP 10812752 A EP10812752 A EP 10812752A EP 2473198 A4 EP2473198 A4 EP 2473198A4
Authority
EP
European Patent Office
Prior art keywords
mixtures
systems
methods
producing hyperpolarized
hyperpolarized materials
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Withdrawn
Application number
EP10812752.3A
Other languages
German (de)
English (en)
Other versions
EP2473198A2 (fr
Inventor
Neal Kalechofsky
Avrum Belzer
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
MILLIKELVIN TECHNOLOGIES LLC
Original Assignee
MILLIKELVIN TECHNOLOGIES LLC
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by MILLIKELVIN TECHNOLOGIES LLC filed Critical MILLIKELVIN TECHNOLOGIES LLC
Publication of EP2473198A2 publication Critical patent/EP2473198A2/fr
Publication of EP2473198A4 publication Critical patent/EP2473198A4/fr
Withdrawn legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/06—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/06—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations
    • A61K49/08—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations characterised by the carrier
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01R—MEASURING ELECTRIC VARIABLES; MEASURING MAGNETIC VARIABLES
    • G01R33/00—Arrangements or instruments for measuring magnetic variables
    • G01R33/20—Arrangements or instruments for measuring magnetic variables involving magnetic resonance
    • G01R33/28—Details of apparatus provided for in groups G01R33/44 - G01R33/64
    • G01R33/282—Means specially adapted for hyperpolarisation or for hyperpolarised contrast agents, e.g. for the generation of hyperpolarised gases using optical pumping cells, for storing hyperpolarised contrast agents or for the determination of the polarisation of a hyperpolarised contrast agent

Landscapes

  • Health & Medical Sciences (AREA)
  • Physics & Mathematics (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Radiology & Medical Imaging (AREA)
  • Epidemiology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Physics & Mathematics (AREA)
  • Condensed Matter Physics & Semiconductors (AREA)
  • Magnetic Resonance Imaging Apparatus (AREA)
  • Physical Or Chemical Processes And Apparatus (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Saccharide Compounds (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Apparatus Associated With Microorganisms And Enzymes (AREA)
EP10812752.3A 2009-08-31 2010-08-31 Systèmes et procédés permettant la production de matériaux hyperpolarisés et leurs mélanges Withdrawn EP2473198A4 (fr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US23864709P 2009-08-31 2009-08-31
PCT/US2010/047310 WO2011026103A2 (fr) 2009-08-31 2010-08-31 Systèmes et procédés permettant la production de matériaux hyperpolarisés et leurs mélanges

Publications (2)

Publication Number Publication Date
EP2473198A2 EP2473198A2 (fr) 2012-07-11
EP2473198A4 true EP2473198A4 (fr) 2015-06-24

Family

ID=43628703

Family Applications (1)

Application Number Title Priority Date Filing Date
EP10812752.3A Withdrawn EP2473198A4 (fr) 2009-08-31 2010-08-31 Systèmes et procédés permettant la production de matériaux hyperpolarisés et leurs mélanges

Country Status (9)

Country Link
EP (1) EP2473198A4 (fr)
JP (1) JP5792726B2 (fr)
KR (1) KR20120101339A (fr)
CN (1) CN102753201A (fr)
AU (1) AU2010286413B2 (fr)
CA (1) CA2772190A1 (fr)
IN (1) IN2012DN02418A (fr)
SG (1) SG178927A1 (fr)
WO (1) WO2011026103A2 (fr)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2009527768A (ja) 2006-02-21 2009-07-30 ベルザー，アブラム 超偏極方法、システムおよび組成物
US8703102B2 (en) 2008-04-04 2014-04-22 Millikelvin Technologies Llc Systems and methods for producing hyperpolarized materials and mixtures thereof
GB2498181A (en) * 2011-12-29 2013-07-10 Bruker Biospin Gmbh Device and method for rapid dynamic nuclear polarisation
US9329246B2 (en) 2012-10-03 2016-05-03 Bruker Biospin Ag Method for hyperpolarization transfer in the liquid state
US9404984B2 (en) 2012-11-06 2016-08-02 Bruker Uk Limited Method of hyperpolarization applying brute force using particulate acceleration agents

Family Cites Families (23)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5545396A (en) * 1994-04-08 1996-08-13 The Research Foundation Of State University Of New York Magnetic resonance imaging using hyperpolarized noble gases
US5617859A (en) 1995-10-02 1997-04-08 General Electric Company Apparatus and methods for magnetic resonance (MR) imaging of cavities using fluids polarized at low temperatures
CN1224502A (zh) * 1996-03-29 1999-07-28 劳伦斯·伯克利国家实验室 利用超极化惰性气体对于核磁共振和磁共振成象质量的提高
US6426058B1 (en) 1996-03-29 2002-07-30 The Regents Of The University Of California Enhancement of NMR and MRI in the presence of hyperpolarized noble gases
US5809801A (en) * 1996-03-29 1998-09-22 The Trustees Of Princeton University Cryogenic accumulator for spin-polarized xenon-129
GB9614139D0 (en) 1996-07-05 1996-09-04 Nycomed Imaging As Method
EP0951650B1 (fr) * 1997-01-08 2003-12-10 Amersham Health AS Procede d'imagerie par resonance magnetique
AU8119298A (en) * 1997-06-19 1999-01-04 Nycomed Imaging As Overhauser magnetic resonance imaging (ormi) method comprising ex vivo polarization of a magnetic resonance (mr) imaging agent
WO1999024080A1 (fr) 1997-11-12 1999-05-20 Nycomed Imaging As Agents marques par para-hydrogene et leur utilisation dans l'imagerie par resonance magnetique
US6278893B1 (en) * 1998-01-05 2001-08-21 Nycomed Imaging As Method of magnetic resonance imaging of a sample with ex vivo polarization of an MR imaging agent
GB0001727D0 (en) 2000-01-25 2000-03-15 Oxford Instr Uk Ltd Hyperpolarization of a noble gas
DK1330659T3 (da) * 2000-11-03 2006-12-18 Amersham Health As Fremgangsmåde og indretning til oplösning af hyperpolariseret, fast materiale til NMR-analyser
AU1403902A (en) 2000-11-03 2002-05-15 Amersham Health As Methods and devices for polarised nmr samples
NO20025738D0 (no) * 2002-11-29 2002-11-29 Amersham Health As Metode
DE102004002639A1 (de) * 2004-01-19 2005-09-15 Forschungszentrum Jülich GmbH Verfahren zur Anreicherung von hyperpolarisierten Atomkernen und Vorrichtung zur Durchführung des Verfahrens
GB0501346D0 (en) * 2005-01-21 2005-03-02 Oxford Instr Molecular Biotool Method of carrying out dynamic nuclear polarization
FR2881226B1 (fr) * 2005-01-27 2007-04-27 Commissariat Energie Atomique Accroissement de la polarisation des spins nucleaires d'une molecule via un transfert de polarisation de type hartmann-hahn utilisant le champ dipolaire moyen cree par une source
GB0514303D0 (en) * 2005-07-12 2005-08-17 Oxford Instr Molecular Biotool Magnet assembly
JP2009527768A (ja) * 2006-02-21 2009-07-30 ベルザー，アブラム 超偏極方法、システムおよび組成物
NL2000122C2 (nl) * 2006-07-03 2008-01-07 Vialle Alternative Fuel System Bufferhouder.
US7631507B2 (en) * 2006-11-02 2009-12-15 General Electric Company Methods and devices for polarized samples for use in MRI
US20080242974A1 (en) * 2007-04-02 2008-10-02 Urbahn John A Method and apparatus to hyperpolarize materials for enhanced mr techniques
US7519492B2 (en) * 2007-05-02 2009-04-14 General Electric Company Apparatus and method for fully automated closed system quality control of a substance

Non-Patent Citations (2)

* Cited by examiner, † Cited by third party
Title
See also references of WO2011026103A2 *
TOMASELLI M ET AL: "HAUPT MAGNETIC DOUBLE RESONANCE", JOURNAL OF CHEMICAL PHYSICS, AMERICAN INSTITUTE OF PHYSICS, US, vol. 118, no. 19, 15 May 2003 (2003-05-15), pages 8559 - 8562, XP009048801, ISSN: 0021-9606, DOI: 10.1063/1.1573635 *

Also Published As

Publication number Publication date
AU2010286413A1 (en) 2012-04-05
WO2011026103A3 (fr) 2011-07-21
JP2013503021A (ja) 2013-01-31
WO2011026103A2 (fr) 2011-03-03
SG178927A1 (en) 2012-04-27
EP2473198A2 (fr) 2012-07-11
CA2772190A1 (fr) 2011-03-03
IN2012DN02418A (fr) 2015-08-21
CN102753201A (zh) 2012-10-24
KR20120101339A (ko) 2012-09-13
JP5792726B2 (ja) 2015-10-14
AU2010286413B2 (en) 2014-11-20

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Effective date: 20150522

RIC1 Information provided on ipc code assigned before grant

Ipc: A61K 49/00 20060101ALI20150518BHEP

Ipc: G01R 33/28 20060101AFI20150518BHEP

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