CA2772190A1 - Systemes et procedes permettant la production de materiaux hyperpolarises et leurs melanges - Google Patents

Systemes et procedes permettant la production de materiaux hyperpolarises et leurs melanges Download PDF

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Publication number
CA2772190A1
CA2772190A1 CA2772190A CA2772190A CA2772190A1 CA 2772190 A1 CA2772190 A1 CA 2772190A1 CA 2772190 A CA2772190 A CA 2772190A CA 2772190 A CA2772190 A CA 2772190A CA 2772190 A1 CA2772190 A1 CA 2772190A1
Authority
CA
Canada
Prior art keywords
nuclei
polarization
hyperpolarized
temperature
magnetic field
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Abandoned
Application number
CA2772190A
Other languages
English (en)
Inventor
Neal Kalechofsky
Avrum Belzer
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
MILLIKELVIN TECHNOLOGIES LLC
Original Assignee
MILLIKELVIN TECHNOLOGIES LLC
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by MILLIKELVIN TECHNOLOGIES LLC filed Critical MILLIKELVIN TECHNOLOGIES LLC
Publication of CA2772190A1 publication Critical patent/CA2772190A1/fr
Abandoned legal-status Critical Current

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/06—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/06—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations
    • A61K49/08—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations characterised by the carrier
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01R—MEASURING ELECTRIC VARIABLES; MEASURING MAGNETIC VARIABLES
    • G01R33/00—Arrangements or instruments for measuring magnetic variables
    • G01R33/20—Arrangements or instruments for measuring magnetic variables involving magnetic resonance
    • G01R33/28—Details of apparatus provided for in groups G01R33/44 - G01R33/64
    • G01R33/282—Means specially adapted for hyperpolarisation or for hyperpolarised contrast agents, e.g. for the generation of hyperpolarised gases using optical pumping cells, for storing hyperpolarised contrast agents or for the determination of the polarisation of a hyperpolarised contrast agent

Landscapes

  • Health & Medical Sciences (AREA)
  • Physics & Mathematics (AREA)
  • Veterinary Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Radiology & Medical Imaging (AREA)
  • Epidemiology (AREA)
  • Condensed Matter Physics & Semiconductors (AREA)
  • General Physics & Mathematics (AREA)
  • Magnetic Resonance Imaging Apparatus (AREA)
  • Physical Or Chemical Processes And Apparatus (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Saccharide Compounds (AREA)
  • Apparatus Associated With Microorganisms And Enzymes (AREA)
CA2772190A 2009-08-31 2010-08-31 Systemes et procedes permettant la production de materiaux hyperpolarises et leurs melanges Abandoned CA2772190A1 (fr)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US23864709P 2009-08-31 2009-08-31
US61/238,647 2009-08-31
PCT/US2010/047310 WO2011026103A2 (fr) 2009-08-31 2010-08-31 Systèmes et procédés permettant la production de matériaux hyperpolarisés et leurs mélanges

Publications (1)

Publication Number Publication Date
CA2772190A1 true CA2772190A1 (fr) 2011-03-03

Family

ID=43628703

Family Applications (1)

Application Number Title Priority Date Filing Date
CA2772190A Abandoned CA2772190A1 (fr) 2009-08-31 2010-08-31 Systemes et procedes permettant la production de materiaux hyperpolarises et leurs melanges

Country Status (9)

Country Link
EP (1) EP2473198A4 (fr)
JP (1) JP5792726B2 (fr)
KR (1) KR20120101339A (fr)
CN (1) CN102753201A (fr)
AU (1) AU2010286413B2 (fr)
CA (1) CA2772190A1 (fr)
IN (1) IN2012DN02418A (fr)
SG (1) SG178927A1 (fr)
WO (1) WO2011026103A2 (fr)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2009527768A (ja) 2006-02-21 2009-07-30 ベルザー，アブラム 超偏極方法、システムおよび組成物
US8703102B2 (en) 2008-04-04 2014-04-22 Millikelvin Technologies Llc Systems and methods for producing hyperpolarized materials and mixtures thereof
GB2498181A (en) * 2011-12-29 2013-07-10 Bruker Biospin Gmbh Device and method for rapid dynamic nuclear polarisation
US9329246B2 (en) 2012-10-03 2016-05-03 Bruker Biospin Ag Method for hyperpolarization transfer in the liquid state
US9404984B2 (en) 2012-11-06 2016-08-02 Bruker Uk Limited Method of hyperpolarization applying brute force using particulate acceleration agents

Family Cites Families (23)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5545396A (en) * 1994-04-08 1996-08-13 The Research Foundation Of State University Of New York Magnetic resonance imaging using hyperpolarized noble gases
US5617859A (en) 1995-10-02 1997-04-08 General Electric Company Apparatus and methods for magnetic resonance (MR) imaging of cavities using fluids polarized at low temperatures
CN1224502A (zh) * 1996-03-29 1999-07-28 劳伦斯·伯克利国家实验室 利用超极化惰性气体对于核磁共振和磁共振成象质量的提高
US5809801A (en) * 1996-03-29 1998-09-22 The Trustees Of Princeton University Cryogenic accumulator for spin-polarized xenon-129
WO1997037239A1 (fr) 1996-03-29 1997-10-09 Lawrence Berkeley National Laboratory Amelioration de la rmn ou de l'irm par la presence de gaz nobles hyperpolarises
GB9614139D0 (en) 1996-07-05 1996-09-04 Nycomed Imaging As Method
JP2001513661A (ja) * 1997-01-08 2001-09-04 ナイコムド イメージング エーエス 磁気共鳴画像法
AU8119298A (en) * 1997-06-19 1999-01-04 Nycomed Imaging As Overhauser magnetic resonance imaging (ormi) method comprising ex vivo polarization of a magnetic resonance (mr) imaging agent
WO1999024080A1 (fr) 1997-11-12 1999-05-20 Nycomed Imaging As Agents marques par para-hydrogene et leur utilisation dans l'imagerie par resonance magnetique
US6278893B1 (en) 1998-01-05 2001-08-21 Nycomed Imaging As Method of magnetic resonance imaging of a sample with ex vivo polarization of an MR imaging agent
GB0001727D0 (en) 2000-01-25 2000-03-15 Oxford Instr Uk Ltd Hyperpolarization of a noble gas
DE60122361T2 (de) * 2000-11-03 2007-06-21 Ge Healthcare As Verfahren und einrichtung zum lösen hyperpolarisierter feststoffe für nmr-analysen
BR0115124B1 (pt) 2000-11-03 2012-12-25 dispositivo para fundir uma amostra hiperpolarizada sàlida, mÉtodo para produzir uma amostra hiperpolarizada fundida, e, uso de um dispositivo ou mÉtodo.
NO20025738D0 (no) * 2002-11-29 2002-11-29 Amersham Health As Metode
DE102004002639A1 (de) * 2004-01-19 2005-09-15 Forschungszentrum Jülich GmbH Verfahren zur Anreicherung von hyperpolarisierten Atomkernen und Vorrichtung zur Durchführung des Verfahrens
GB0501346D0 (en) * 2005-01-21 2005-03-02 Oxford Instr Molecular Biotool Method of carrying out dynamic nuclear polarization
FR2881226B1 (fr) * 2005-01-27 2007-04-27 Commissariat Energie Atomique Accroissement de la polarisation des spins nucleaires d'une molecule via un transfert de polarisation de type hartmann-hahn utilisant le champ dipolaire moyen cree par une source
GB0514303D0 (en) * 2005-07-12 2005-08-17 Oxford Instr Molecular Biotool Magnet assembly
JP2009527768A (ja) * 2006-02-21 2009-07-30 ベルザー，アブラム 超偏極方法、システムおよび組成物
NL2000122C2 (nl) * 2006-07-03 2008-01-07 Vialle Alternative Fuel System Bufferhouder.
US7631507B2 (en) * 2006-11-02 2009-12-15 General Electric Company Methods and devices for polarized samples for use in MRI
US20080242974A1 (en) * 2007-04-02 2008-10-02 Urbahn John A Method and apparatus to hyperpolarize materials for enhanced mr techniques
US7519492B2 (en) * 2007-05-02 2009-04-14 General Electric Company Apparatus and method for fully automated closed system quality control of a substance

Also Published As

Publication number Publication date
KR20120101339A (ko) 2012-09-13
EP2473198A2 (fr) 2012-07-11
JP2013503021A (ja) 2013-01-31
AU2010286413A1 (en) 2012-04-05
WO2011026103A3 (fr) 2011-07-21
JP5792726B2 (ja) 2015-10-14
AU2010286413B2 (en) 2014-11-20
SG178927A1 (en) 2012-04-27
WO2011026103A2 (fr) 2011-03-03
IN2012DN02418A (fr) 2015-08-21
EP2473198A4 (fr) 2015-06-24
CN102753201A (zh) 2012-10-24

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Legal Events

Date Code Title Description
EEER Examination request

Effective date: 20150731

FZDE Discontinued

Effective date: 20180228