CA2720333C - Fabrication, transport et livraison de materiau contenant des noyaux hautement polarises - Google Patents

Fabrication, transport et livraison de materiau contenant des noyaux hautement polarises Download PDF

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Publication number
CA2720333C
CA2720333C CA2720333A CA2720333A CA2720333C CA 2720333 C CA2720333 C CA 2720333C CA 2720333 A CA2720333 A CA 2720333A CA 2720333 A CA2720333 A CA 2720333A CA 2720333 C CA2720333 C CA 2720333C
Authority
CA
Canada
Prior art keywords
temperature
nuclei
hyperpolarized
increasing
magnetic field
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
CA2720333A
Other languages
English (en)
Other versions
CA2720333A1 (fr
Inventor
Neal Kalechofsky
Avrum Belzer
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
MILLIKELVIN TECHNOLOGIES LLC
Original Assignee
MILLIKELVIN TECHNOLOGIES LLC
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from US12/193,536 external-priority patent/US20090016964A1/en
Application filed by MILLIKELVIN TECHNOLOGIES LLC filed Critical MILLIKELVIN TECHNOLOGIES LLC
Publication of CA2720333A1 publication Critical patent/CA2720333A1/fr
Application granted granted Critical
Publication of CA2720333C publication Critical patent/CA2720333C/fr
Expired - Fee Related legal-status Critical Current
Anticipated expiration legal-status Critical

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/06—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations
    • A61K49/08—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations characterised by the carrier
    • A61K49/10—Organic compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01R—MEASURING ELECTRIC VARIABLES; MEASURING MAGNETIC VARIABLES
    • G01R33/00—Arrangements or instruments for measuring magnetic variables
    • G01R33/20—Arrangements or instruments for measuring magnetic variables involving magnetic resonance
    • G01R33/28—Details of apparatus provided for in groups G01R33/44 - G01R33/64
    • G01R33/282—Means specially adapted for hyperpolarisation or for hyperpolarised contrast agents, e.g. for the generation of hyperpolarised gases using optical pumping cells, for storing hyperpolarised contrast agents or for the determination of the polarisation of a hyperpolarised contrast agent
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01R—MEASURING ELECTRIC VARIABLES; MEASURING MAGNETIC VARIABLES
    • G01R33/00—Arrangements or instruments for measuring magnetic variables
    • G01R33/20—Arrangements or instruments for measuring magnetic variables involving magnetic resonance
    • G01R33/44—Arrangements or instruments for measuring magnetic variables involving magnetic resonance using nuclear magnetic resonance [NMR]
    • G01R33/48—NMR imaging systems
    • G01R33/54—Signal processing systems, e.g. using pulse sequences ; Generation or control of pulse sequences; Operator console
    • G01R33/56—Image enhancement or correction, e.g. subtraction or averaging techniques, e.g. improvement of signal-to-noise ratio and resolution
    • G01R33/5601—Image enhancement or correction, e.g. subtraction or averaging techniques, e.g. improvement of signal-to-noise ratio and resolution involving use of a contrast agent for contrast manipulation, e.g. a paramagnetic, super-paramagnetic, ferromagnetic or hyperpolarised contrast agent

Landscapes

  • Health & Medical Sciences (AREA)
  • Physics & Mathematics (AREA)
  • General Health & Medical Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Veterinary Medicine (AREA)
  • Condensed Matter Physics & Semiconductors (AREA)
  • General Physics & Mathematics (AREA)
  • Public Health (AREA)
  • Chemical & Material Sciences (AREA)
  • Radiology & Medical Imaging (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Organic Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Signal Processing (AREA)
  • High Energy & Nuclear Physics (AREA)
  • Epidemiology (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Magnetic Resonance Imaging Apparatus (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Saccharide Compounds (AREA)
CA2720333A 2008-04-04 2009-04-06 Fabrication, transport et livraison de materiau contenant des noyaux hautement polarises Expired - Fee Related CA2720333C (fr)

Applications Claiming Priority (7)

Application Number Priority Date Filing Date Title
US4239808P 2008-04-04 2008-04-04
US61/042,398 2008-04-04
US12/193,536 US20090016964A1 (en) 2006-02-21 2008-08-18 Hyperpolarization methods, systems and compositions
US12/193,536 2008-08-18
US11105008P 2008-11-04 2008-11-04
US61/111,050 2008-11-04
PCT/US2009/039696 WO2009146153A2 (fr) 2008-04-04 2009-04-06 Fabrication, transport et livraison de matériau contenant des noyaux hautement polarisés

Publications (2)

Publication Number Publication Date
CA2720333A1 CA2720333A1 (fr) 2009-12-03
CA2720333C true CA2720333C (fr) 2017-01-24

Family

ID=41377877

Family Applications (1)

Application Number Title Priority Date Filing Date
CA2720333A Expired - Fee Related CA2720333C (fr) 2008-04-04 2009-04-06 Fabrication, transport et livraison de materiau contenant des noyaux hautement polarises

Country Status (4)

Country Link
EP (1) EP2459234A4 (fr)
AU (1) AU2009251528B2 (fr)
CA (1) CA2720333C (fr)
WO (1) WO2009146153A2 (fr)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8703102B2 (en) 2008-04-04 2014-04-22 Millikelvin Technologies Llc Systems and methods for producing hyperpolarized materials and mixtures thereof
WO2007136439A2 (fr) 2006-02-21 2007-11-29 Avrum Belzer Procédés, systèmes et compositions d'hyperporalisation

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB0001727D0 (en) 2000-01-25 2000-03-15 Oxford Instr Uk Ltd Hyperpolarization of a noble gas
WO2004096333A1 (fr) * 2003-04-22 2004-11-11 Medi-Physics, Inc. Systeme de mesure et de commande d'un volume tidal compatible avec mri/nmr, procedes et dispositifs d'administration de gaz respiratoire et hyperpolarise
DE102004002639A1 (de) * 2004-01-19 2005-09-15 Forschungszentrum Jülich GmbH Verfahren zur Anreicherung von hyperpolarisierten Atomkernen und Vorrichtung zur Durchführung des Verfahrens
DE102004011874B4 (de) * 2004-03-11 2006-04-20 Universitätsklinikum Freiburg Verfahren zur Messung der Magnetresonanz (NMR) mittels Continuously Refocused Multiecho Spectroscopic Imaging
GB0514303D0 (en) 2005-07-12 2005-08-17 Oxford Instr Molecular Biotool Magnet assembly
WO2007136439A2 (fr) * 2006-02-21 2007-11-29 Avrum Belzer Procédés, systèmes et compositions d'hyperporalisation

Also Published As

Publication number Publication date
WO2009146153A2 (fr) 2009-12-03
AU2009251528B2 (en) 2014-09-18
CA2720333A1 (fr) 2009-12-03
EP2459234A2 (fr) 2012-06-06
WO2009146153A3 (fr) 2010-01-21
AU2009251528A1 (en) 2009-12-03
EP2459234A4 (fr) 2013-07-31

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Legal Events

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EEER Examination request

Effective date: 20140115

MKLA Lapsed

Effective date: 20180406