CN102753201A - 用于制造超极化材料和其混合物的系统和方法 - Google Patents

用于制造超极化材料和其混合物的系统和方法 Download PDF

Info

Publication number
CN102753201A
CN102753201A CN2010800471391A CN201080047139A CN102753201A CN 102753201 A CN102753201 A CN 102753201A CN 2010800471391 A CN2010800471391 A CN 2010800471391A CN 201080047139 A CN201080047139 A CN 201080047139A CN 102753201 A CN102753201 A CN 102753201A
Authority
CN
China
Prior art keywords
hyperpolarized
temperature
magnetic field
location
polarization
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
CN2010800471391A
Other languages
English (en)
Chinese (zh)
Inventor
尼尔·卡列肖夫斯基
阿夫鲁姆·贝尔策
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Individual
Original Assignee
Individual
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Individual filed Critical Individual
Publication of CN102753201A publication Critical patent/CN102753201A/zh
Pending legal-status Critical Current

Links

Images

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/06—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/06—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations
    • A61K49/08—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations characterised by the carrier
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01R—MEASURING ELECTRIC VARIABLES; MEASURING MAGNETIC VARIABLES
    • G01R33/00—Arrangements or instruments for measuring magnetic variables
    • G01R33/20—Arrangements or instruments for measuring magnetic variables involving magnetic resonance
    • G01R33/28—Details of apparatus provided for in groups G01R33/44 - G01R33/64
    • G01R33/282—Means specially adapted for hyperpolarisation or for hyperpolarised contrast agents, e.g. for the generation of hyperpolarised gases using optical pumping cells, for storing hyperpolarised contrast agents or for the determination of the polarisation of a hyperpolarised contrast agent

Landscapes

  • Health & Medical Sciences (AREA)
  • Physics & Mathematics (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Radiology & Medical Imaging (AREA)
  • Epidemiology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Physics & Mathematics (AREA)
  • Condensed Matter Physics & Semiconductors (AREA)
  • Magnetic Resonance Imaging Apparatus (AREA)
  • Physical Or Chemical Processes And Apparatus (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Saccharide Compounds (AREA)
  • Apparatus Associated With Microorganisms And Enzymes (AREA)
CN2010800471391A 2009-08-31 2010-08-31 用于制造超极化材料和其混合物的系统和方法 Pending CN102753201A (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US23864709P 2009-08-31 2009-08-31
US61/238,647 2009-08-31
PCT/US2010/047310 WO2011026103A2 (en) 2009-08-31 2010-08-31 Systems and methods for producing hyperpolarized materials and mixtures thereof

Publications (1)

Publication Number Publication Date
CN102753201A true CN102753201A (zh) 2012-10-24

Family

ID=43628703

Family Applications (1)

Application Number Title Priority Date Filing Date
CN2010800471391A Pending CN102753201A (zh) 2009-08-31 2010-08-31 用于制造超极化材料和其混合物的系统和方法

Country Status (9)

Country Link
EP (1) EP2473198A4 (enExample)
JP (1) JP5792726B2 (enExample)
KR (1) KR20120101339A (enExample)
CN (1) CN102753201A (enExample)
AU (1) AU2010286413B2 (enExample)
CA (1) CA2772190A1 (enExample)
IN (1) IN2012DN02418A (enExample)
SG (1) SG178927A1 (enExample)
WO (1) WO2011026103A2 (enExample)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR101095943B1 (ko) 2006-02-21 2011-12-19 밀리켈빈 테크놀로지스 엘엘씨 과분극화 방법, 시스템 및 조성물
US8703102B2 (en) 2008-04-04 2014-04-22 Millikelvin Technologies Llc Systems and methods for producing hyperpolarized materials and mixtures thereof
GB2498181A (en) 2011-12-29 2013-07-10 Bruker Biospin Gmbh Device and method for rapid dynamic nuclear polarisation
US9329246B2 (en) 2012-10-03 2016-05-03 Bruker Biospin Ag Method for hyperpolarization transfer in the liquid state
US9404984B2 (en) 2012-11-06 2016-08-02 Bruker Uk Limited Method of hyperpolarization applying brute force using particulate acceleration agents

Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN1224502A (zh) * 1996-03-29 1999-07-28 劳伦斯·伯克利国家实验室 利用超极化惰性气体对于核磁共振和磁共振成象质量的提高
CN1285044A (zh) * 1998-01-05 2001-02-21 耐克麦德英梅金公司 磁共振研究方法
US6453188B1 (en) * 1997-01-08 2002-09-17 Amersham Health As Method of magnetic resonance imaging
WO2007007022A1 (en) * 2005-07-12 2007-01-18 Oxford Instruments Molecular Biotools Limited Magnet assembly for dnp and/or nmr applications

Family Cites Families (19)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5545396A (en) * 1994-04-08 1996-08-13 The Research Foundation Of State University Of New York Magnetic resonance imaging using hyperpolarized noble gases
US5617859A (en) 1995-10-02 1997-04-08 General Electric Company Apparatus and methods for magnetic resonance (MR) imaging of cavities using fluids polarized at low temperatures
US5809801A (en) * 1996-03-29 1998-09-22 The Trustees Of Princeton University Cryogenic accumulator for spin-polarized xenon-129
RU2186405C2 (ru) 1996-03-29 2002-07-27 Лоренс Беркли Нэшнл Лэборэтори Усиление ядерного магнитного резонанса (ямр) и магниторезонансной визуализации (мрв) в присутствии гиперполяризованных благородных газов
GB9614139D0 (en) 1996-07-05 1996-09-04 Nycomed Imaging As Method
CA2290808A1 (en) * 1997-06-19 1998-12-23 Jan Henrik Ardenkjaer-Larsen Overhauser magnetic resonance imaging (ormi) method comprising ex vivo polarization of a magnetic resonance (mr) imaging agent
KR100600670B1 (ko) 1997-11-12 2006-07-13 지이 헬스케어 에이에스 파라수소 표지된 작용물질 및 자기공명영상에서의 그의 용도
GB0001727D0 (en) 2000-01-25 2000-03-15 Oxford Instr Uk Ltd Hyperpolarization of a noble gas
AU1403902A (en) 2000-11-03 2002-05-15 Amersham Health As Methods and devices for polarised nmr samples
DK1330659T3 (da) * 2000-11-03 2006-12-18 Amersham Health As Fremgangsmåde og indretning til oplösning af hyperpolariseret, fast materiale til NMR-analyser
NO20025738D0 (no) * 2002-11-29 2002-11-29 Amersham Health As Metode
DE102004002639A1 (de) * 2004-01-19 2005-09-15 Forschungszentrum Jülich GmbH Verfahren zur Anreicherung von hyperpolarisierten Atomkernen und Vorrichtung zur Durchführung des Verfahrens
GB0501346D0 (en) * 2005-01-21 2005-03-02 Oxford Instr Molecular Biotool Method of carrying out dynamic nuclear polarization
FR2881226B1 (fr) * 2005-01-27 2007-04-27 Commissariat Energie Atomique Accroissement de la polarisation des spins nucleaires d'une molecule via un transfert de polarisation de type hartmann-hahn utilisant le champ dipolaire moyen cree par une source
KR101095943B1 (ko) * 2006-02-21 2011-12-19 밀리켈빈 테크놀로지스 엘엘씨 과분극화 방법, 시스템 및 조성물
NL2000122C2 (nl) * 2006-07-03 2008-01-07 Vialle Alternative Fuel System Bufferhouder.
US7631507B2 (en) * 2006-11-02 2009-12-15 General Electric Company Methods and devices for polarized samples for use in MRI
US20080242974A1 (en) * 2007-04-02 2008-10-02 Urbahn John A Method and apparatus to hyperpolarize materials for enhanced mr techniques
US7519492B2 (en) * 2007-05-02 2009-04-14 General Electric Company Apparatus and method for fully automated closed system quality control of a substance

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN1224502A (zh) * 1996-03-29 1999-07-28 劳伦斯·伯克利国家实验室 利用超极化惰性气体对于核磁共振和磁共振成象质量的提高
US6453188B1 (en) * 1997-01-08 2002-09-17 Amersham Health As Method of magnetic resonance imaging
CN1285044A (zh) * 1998-01-05 2001-02-21 耐克麦德英梅金公司 磁共振研究方法
WO2007007022A1 (en) * 2005-07-12 2007-01-18 Oxford Instruments Molecular Biotools Limited Magnet assembly for dnp and/or nmr applications

Also Published As

Publication number Publication date
SG178927A1 (en) 2012-04-27
EP2473198A4 (en) 2015-06-24
AU2010286413B2 (en) 2014-11-20
AU2010286413A1 (en) 2012-04-05
WO2011026103A2 (en) 2011-03-03
IN2012DN02418A (enExample) 2015-08-21
JP2013503021A (ja) 2013-01-31
WO2011026103A3 (en) 2011-07-21
JP5792726B2 (ja) 2015-10-14
CA2772190A1 (en) 2011-03-03
KR20120101339A (ko) 2012-09-13
EP2473198A2 (en) 2012-07-11

Similar Documents

Publication Publication Date Title
US8703102B2 (en) Systems and methods for producing hyperpolarized materials and mixtures thereof
CA2643306C (en) Hyperpolarization methods, systems and compositions
US6125654A (en) Bulk production and usage of hyperpolarized 129 Xenon
US20140223923A1 (en) Systems and methods for producing hyperpolarized materials and mixtures thereof
Krjukov et al. Brute force polarization of 129Xe
US20220018915A1 (en) Systems and methods for generation of hyperpolarized materials
CN102753201A (zh) 用于制造超极化材料和其混合物的系统和方法
US20080100293A1 (en) Method of Carrying Out Dynamic Nuclear Polarization
US20110050228A1 (en) agent for transporting nuclear spin order and for magnetic resonance imaging
EP3081952B1 (en) Transportable long-lived hyperpolarized samples
Eills et al. Spin hyperpolarization in modern magnetic resonance
EP2917749B1 (en) Method of hyperpolarization applying brute force using particulate acceleration agents
JP4420224B2 (ja) 過分極１２９Ｘｅの製造法
CA2720333C (en) Manufacture, transport and delivery of material containing highly polarized nuclei
El Darai et al. Porous Functionalized Polymers enable Generating and Transporting Hyperpolarized Arbitrary Solutions
US9658300B1 (en) Method and apparatus for preparation of spin polarized reagents
AU2013205838B2 (en) Hyperpolarization Methods, Systems and Compositions
Capozzi Methods to hyperpolarize nuclear spins via dissolution and sublimation DNP at high magnetic field
O'Neill Brute force polarisation of xenon-129
Ardenkjaer-Larsen et al. Hyperpolarization via dissolution Dynamic Nuclear Polarization: new technological and methodological advances
Nikolaou Spectroscopic studies of nuclear spins polarized via spin exchange optical pumping and dynamic coupling in cryptophane host-guest complexes

Legal Events

Date Code Title Description
C06 Publication
PB01 Publication
C10 Entry into substantive examination
SE01 Entry into force of request for substantive examination
AD01 Patent right deemed abandoned
AD01 Patent right deemed abandoned

Effective date of abandoning: 20171208