AU2010286413B2 - Systems and methods for producing hyperpolarized materials and mixtures thereof - Google Patents

Systems and methods for producing hyperpolarized materials and mixtures thereof Download PDF

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Publication number
AU2010286413B2
AU2010286413B2 AU2010286413A AU2010286413A AU2010286413B2 AU 2010286413 B2 AU2010286413 B2 AU 2010286413B2 AU 2010286413 A AU2010286413 A AU 2010286413A AU 2010286413 A AU2010286413 A AU 2010286413A AU 2010286413 B2 AU2010286413 B2 AU 2010286413B2
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AU
Australia
Prior art keywords
nuclei
polarization
temperature
hyperpolarized
magnetic field
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Ceased
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AU2010286413A
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English (en)
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AU2010286413A1 (en
Inventor
Avrum Belzer
Neal Kalechofsky
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MILLIKELVIN TECHNOLOGIES LLC
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Millikelvin Tech LLC
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Publication of AU2010286413B2 publication Critical patent/AU2010286413B2/en
Ceased legal-status Critical Current
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/06—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/06—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations
    • A61K49/08—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations characterised by the carrier
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01R—MEASURING ELECTRIC VARIABLES; MEASURING MAGNETIC VARIABLES
    • G01R33/00—Arrangements or instruments for measuring magnetic variables
    • G01R33/20—Arrangements or instruments for measuring magnetic variables involving magnetic resonance
    • G01R33/28—Details of apparatus provided for in groups G01R33/44 - G01R33/64
    • G01R33/282—Means specially adapted for hyperpolarisation or for hyperpolarised contrast agents, e.g. for the generation of hyperpolarised gases using optical pumping cells, for storing hyperpolarised contrast agents or for the determination of the polarisation of a hyperpolarised contrast agent

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  • Health & Medical Sciences (AREA)
  • Physics & Mathematics (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Radiology & Medical Imaging (AREA)
  • Epidemiology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Physics & Mathematics (AREA)
  • Condensed Matter Physics & Semiconductors (AREA)
  • Magnetic Resonance Imaging Apparatus (AREA)
  • Physical Or Chemical Processes And Apparatus (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Saccharide Compounds (AREA)
  • Apparatus Associated With Microorganisms And Enzymes (AREA)
AU2010286413A 2009-08-31 2010-08-31 Systems and methods for producing hyperpolarized materials and mixtures thereof Ceased AU2010286413B2 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US23864709P 2009-08-31 2009-08-31
US61/238,647 2009-08-31
PCT/US2010/047310 WO2011026103A2 (en) 2009-08-31 2010-08-31 Systems and methods for producing hyperpolarized materials and mixtures thereof

Publications (2)

Publication Number Publication Date
AU2010286413A1 AU2010286413A1 (en) 2012-04-05
AU2010286413B2 true AU2010286413B2 (en) 2014-11-20

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ID=43628703

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AU2010286413A Ceased AU2010286413B2 (en) 2009-08-31 2010-08-31 Systems and methods for producing hyperpolarized materials and mixtures thereof

Country Status (9)

Country Link
EP (1) EP2473198A4 (enExample)
JP (1) JP5792726B2 (enExample)
KR (1) KR20120101339A (enExample)
CN (1) CN102753201A (enExample)
AU (1) AU2010286413B2 (enExample)
CA (1) CA2772190A1 (enExample)
IN (1) IN2012DN02418A (enExample)
SG (1) SG178927A1 (enExample)
WO (1) WO2011026103A2 (enExample)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8703102B2 (en) 2008-04-04 2014-04-22 Millikelvin Technologies Llc Systems and methods for producing hyperpolarized materials and mixtures thereof
WO2007136439A2 (en) 2006-02-21 2007-11-29 Avrum Belzer Hyperpolarization methods, systems and compositions
GB2498181A (en) * 2011-12-29 2013-07-10 Bruker Biospin Gmbh Device and method for rapid dynamic nuclear polarisation
US9329246B2 (en) 2012-10-03 2016-05-03 Bruker Biospin Ag Method for hyperpolarization transfer in the liquid state
US9404984B2 (en) 2012-11-06 2016-08-02 Bruker Uk Limited Method of hyperpolarization applying brute force using particulate acceleration agents

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2007136439A2 (en) * 2006-02-21 2007-11-29 Avrum Belzer Hyperpolarization methods, systems and compositions

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US5545396A (en) * 1994-04-08 1996-08-13 The Research Foundation Of State University Of New York Magnetic resonance imaging using hyperpolarized noble gases
US5617859A (en) 1995-10-02 1997-04-08 General Electric Company Apparatus and methods for magnetic resonance (MR) imaging of cavities using fluids polarized at low temperatures
CN1224502A (zh) * 1996-03-29 1999-07-28 劳伦斯·伯克利国家实验室 利用超极化惰性气体对于核磁共振和磁共振成象质量的提高
EP0890114A1 (en) 1996-03-29 1999-01-13 Lawrence Berkeley National Laboratory Enhancement of nmr and mri in the presence of hyperpolarized noble gases
US5809801A (en) * 1996-03-29 1998-09-22 The Trustees Of Princeton University Cryogenic accumulator for spin-polarized xenon-129
GB9614139D0 (en) 1996-07-05 1996-09-04 Nycomed Imaging As Method
DE69820415T2 (de) * 1997-01-08 2004-09-16 Amersham Health As Verfahren zur bilderzeugung mit magnetischer resonanz
AU8119298A (en) * 1997-06-19 1999-01-04 Nycomed Imaging As Overhauser magnetic resonance imaging (ormi) method comprising ex vivo polarization of a magnetic resonance (mr) imaging agent
EP1047455B1 (en) 1997-11-12 2008-08-20 GE Healthcare AS Para-hydrogen labelled agents and their use in non-proton magnetic resonance imaging
US6278893B1 (en) * 1998-01-05 2001-08-21 Nycomed Imaging As Method of magnetic resonance imaging of a sample with ex vivo polarization of an MR imaging agent
GB0001727D0 (en) 2000-01-25 2000-03-15 Oxford Instr Uk Ltd Hyperpolarization of a noble gas
DK1330659T3 (da) * 2000-11-03 2006-12-18 Amersham Health As Fremgangsmåde og indretning til oplösning af hyperpolariseret, fast materiale til NMR-analyser
CA2427726C (en) 2000-11-03 2012-01-24 Amersham Health As Methods and devices for polarised nmr samples
NO20025738D0 (no) * 2002-11-29 2002-11-29 Amersham Health As Metode
DE102004002639A1 (de) * 2004-01-19 2005-09-15 Forschungszentrum Jülich GmbH Verfahren zur Anreicherung von hyperpolarisierten Atomkernen und Vorrichtung zur Durchführung des Verfahrens
GB0501346D0 (en) * 2005-01-21 2005-03-02 Oxford Instr Molecular Biotool Method of carrying out dynamic nuclear polarization
FR2881226B1 (fr) * 2005-01-27 2007-04-27 Commissariat Energie Atomique Accroissement de la polarisation des spins nucleaires d'une molecule via un transfert de polarisation de type hartmann-hahn utilisant le champ dipolaire moyen cree par une source
GB0514303D0 (en) * 2005-07-12 2005-08-17 Oxford Instr Molecular Biotool Magnet assembly
NL2000122C2 (nl) * 2006-07-03 2008-01-07 Vialle Alternative Fuel System Bufferhouder.
US7631507B2 (en) * 2006-11-02 2009-12-15 General Electric Company Methods and devices for polarized samples for use in MRI
US20080242974A1 (en) * 2007-04-02 2008-10-02 Urbahn John A Method and apparatus to hyperpolarize materials for enhanced mr techniques
US7519492B2 (en) * 2007-05-02 2009-04-14 General Electric Company Apparatus and method for fully automated closed system quality control of a substance

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2007136439A2 (en) * 2006-02-21 2007-11-29 Avrum Belzer Hyperpolarization methods, systems and compositions

Also Published As

Publication number Publication date
WO2011026103A2 (en) 2011-03-03
IN2012DN02418A (enExample) 2015-08-21
KR20120101339A (ko) 2012-09-13
EP2473198A2 (en) 2012-07-11
CN102753201A (zh) 2012-10-24
CA2772190A1 (en) 2011-03-03
WO2011026103A3 (en) 2011-07-21
JP5792726B2 (ja) 2015-10-14
JP2013503021A (ja) 2013-01-31
EP2473198A4 (en) 2015-06-24
AU2010286413A1 (en) 2012-04-05
SG178927A1 (en) 2012-04-27

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MK14 Patent ceased section 143(a) (annual fees not paid) or expired